In the biosciences, response variables are often observed more than once per individual. This enables the researcher to study the development of the variable of interest within individuals, thereby eliminating the variation among individuals, and thus increasing the power of the design. However, since observations on the same individual are almost always correlated, special methods are needed to deal with this dependence.
- Entry requirements:
- Basic programming experience in R, e.g. the ability to read in data and run a simple linear model
- To have followed at least one course in basic statistical methods up to and including simple and multiple linear regression
- Familiarity with likelihood methods (Wald, score and likelihood ratio tests) will facilitate understanding of the theoretical background.
- Start date(s):
- Face-to-face: 6 April 2020. Online: 4 November 2019
- Time investment:
- Face-to-face: five full working days. Online: 6 weeks 7 hours per week
- University Medical Center Utrecht
- Faculty of Medicine
- Fee: This fee is exempt from VAT
- Face-to-face: € 830 Online: €785
Mixed models are one way of analyzing this kind of data. This statistical technique allows for the dependency of measurements in hierarchically structured data, and separately examines the effects of variables at different levels. An important part of the course will be about the use (and theory) of linear mixed effects models (LME’s).
Starting with analysis of summary statistics on each individual's observations, this course will lead you to more advanced methods for analyzing multilevel and longitudinal data. Similarities between longitudinal data analysis and multilevel analysis will be clarified. The course will focus primarily on continuous outcome variables, but attention will also be paid to dichotomous and count data.
At the end of the course, you are able to:
- understand the difference between fixed and random effects;
- know when to apply a mixed model in practice;
- know the most commonly used methods for checking model appropriateness and model fit;
- perform mixed model analyses using statistical software (R, SPSS);
- interpret the output of mixed model analyses in terms of the context of the research question(s);
- report the results of mixed model analyses to non-statistical investigators.