Advanced Diagnostic Research

"Test research is not necessarily the same as diagnostic research."

Diagnostic research in the past focused particularly on estimating the sensitivity and specificity of individual diagnostic tests. This course will demonstrate that this so called ‘test research’ is not necessarily the same as diagnostic research. Furthermore, we will widen the horizon by proposing modern methods of diagnostic research and data analysis in which a patient’s test result can and should be considered in the context of other patient characteristics or test results.

Start date(s): 
25 November 2019, 10 February 2020
Face-to-face: 10 February 2020 Online: 25 November 2019
Time investment: 
Face-to-face: five full working days Online: three weeks, 14 hours per week
University Medical Center Utrecht
Faculty of Medicine
Fee: This fee is exempt from VAT
Face-to-face: € 830 Online: € 785
Extra information: 

The face-to-face course consists of lectures, computer practicals, group presentations and group exercises. 

The online course consists of web lectures, individual assignments, group assignment and a take-home exam which has to be submitted online before the deadline. 

Software program R is required for this course. It is available for free.

The research methodes introduced in this course enable you to do a direct estimation of individual probabilities of disease presence based on all diagnostic information and do an evaluation of the extent to which a particular diagnostic test has true added value in the clinical context. 

At the end of this course, you are able to: 

  • Describe the principles and design of primary diagnostic studies
  • Describe the advantages and disadvantages of different approaches in primary diagnostic studies
  • Describe the validity aspects of primary diagnostic studies
  • Describe the methods for data collection in the different study designs of primary diagnostic studies
  • Explain the differences between different design and analytical approaches in primary diagnostic studies
  • Name the different measures of diagnostic value or accuracy that can be calculated from primary diagnostic studies
  • Explain and use modern design and analytical approaches instead of the classical approach in primary diagnostic studies
  • Describe the clinical utility and health technology assessment of diagnostic impact studies
  • Choose an appropriate study design and analytical approach to be used in a specific situation or to answer a specific study question in both primary diagnostic studies


Please contact our Educational Office:
​088 75 69710