dr. N.I. (Nathaniel) Martin
N.I.Martin@uu.nl
Gegenereerd op 2017-09-23 02:15:47


Profile

Nathaniel I. Martin Ph.D. Associate Professor

Department of Chemical Biology & Drug Discovery
Utrecht Institute for Pharmaceutical Science, Utrecht University

 

The Martin sub-group is part of the Department of Chemical Biology & Drug Discovery, hosted within the Utrecht Institute for Pharmaceutical Sciences (UIPS) at Utrecht University. We apply synthetic organic chemistry to address biologically interesting and medicinally relevant questions. Our research interests are broad and include investigating new (bio)chemical approaches to combatting infectious disease as well as developing new molecular tools with which to study cancer and epigenetic processes.

The Martin research team is comprised of a number of PhD, Master, and Bachelor student researchers. We also regularly host foreign students who visit Utrecht for a research internship abroad (for example Erasmus students). If you are interested in joining, feel free to contact us!

 

 

 

 

 

 

Gegenereerd op 2017-09-23 02:15:47
Curriculum vitae

Nathaniel Isaac Martin

Experience and Education

2016-present: Associate Professor Department of Medicinal Chemistry and Chemical Biology, University of Utrecht, Utrecht, The Netherlands 

2010-2015: Assistant Professor Department of Medicinal Chemistry and Chemical Biology, University of Utrecht, Utrecht, The Netherlands 

2007-2010: Junior Principle Investigator Department of Medicinal Chemistry and Chemical Biology, University of Utrecht, Utrecht, The Netherlands

2004-2007: Postdoctoral Fellow Department of Chemistry, University of California Berkeley, Berkeley California, USA 

1999-2004: Ph.D. Studies Department of Chemistry, University of Alberta, Edmonton Alberta, Canada.

 

 

 

 

 

 

Gegenereerd op 2017-09-23 02:15:47

50. van Harten, R.M.; Willems, R.J.L.; Martin, N.I.; Hendrickx, A.P.A. Multidrug Resistant Enterococcal Infections: (2017) New Compounds, Novel Antimicrobial Therapies? Trends in Microbiology, Accepted (manuscript in press).

49. Oude Blenke, E.; Sleszynska,M.; Evers, M.J.W.; Storm, G.; Martin, N.I. Mastrobattista, E. (2017) Strategies for the activation and release of the membranolytic peptide melittin from liposomes using endosomal pH as a trigger. Bioconjugate Chemistry, Accepted (manuscript in press). DOI: 10.1021/acs.bioconjchem.6b00677.

48. Cura, V., Marechal, N., Troffer-Charlier, N., Strub, J-M., van Haren, M.J., Martin, N.I. Cianferani, S., Bonnefond, L., Cavarelli, J. (2017) Functional insights from structural studies of protein arginine methyltransferase 2. The FEBS Journal, 284, 77-96. DOI: 10.1111/febs.13953.

47. van ‘t Veer, I.L., Leloup, N.O.L., Egan, A.J.F., Janssen, B.J.C., Martin, N.I., Vollmer, W., Breukink, E. (2016) Site specific immobilization of the peptidoglycan synthase PBP1B on a surface plasmon resonance chip surface. ChemBioChem17, 2250-2256. DOI: 10.1002/cbic.201600461.

46. Pagliero R.J., D’Astolfo D.S., Lelieveld D., Pratiwi R.D., Aits S., Jaattela M., Martin N.I., Klumperman J., and Egan D.A. (2016) Discovery of Small Molecules That Induce Lysosomal Cell Death in Cancer Cell Lines Using an Image-Based Screening Platform. ASSAY and Drug Development Technologies14, 489-510. DOI: 10.1089/adt.2016.727.

45. van Haren, M.J., Sastre Toraño, J., Sartini, D., Emanuelli, M., Parsons, R.B., *Martin, N.I. (2016) A rapid and efficient assay for the characterization of substrates and inhibitors of nicotinamide N-methyltransferase. Biochemistry, 55, 5307-5315. DOI: 10.1021/acs.biochem.6b00733.

44. Sevšek, A., Celan, M., Erjavec, B., Quarles van Ufford, L., Sastre Toraño, J., Moret, E.E., *Pieters, R.J, *Martin, N.I. (2016) Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase. Organic and Biomolecular Chemistry, 14, 8670-8673. DOI: 10.1039/C6OB01735E.

43. Thomas, M.G., Sartini, D., Emanuelli, M., van Haren, M.J., Martin, N.I., Mountford, D.M., Barlow, D.J., Klamt, F., Ramsden, D.B., Reza, M., Parsons, R.B. (2016) Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway. Biochemical Journal, 473, 3253-3267. DOI: 10.1042/BCJ20160219.

42. Kleijn, L.H.J., Oppedijk, S.F., 't Hart, P., van Harten, R.M., Martin-Visscher, L.A., Kemmink, J., Breukink, E., *Martin, N.I. (2016) Total Synthesis of Laspartomycin C and Characterization of its Antibacterial Mechanism of Action. Journal of Medicinal Chemistry, 59, 3569–3574DOI: 10.1021/acs.jmedchem.6b00219.

41. ’t Hart, P., Oppedijk, S.F., Breukink, E., *Martin, N.I. (2016) New insights into nisin’s antibacterial mechanism revealed by binding studies with synthetic lipid II analogues. Biochemistry, 55, 232-237. DOI: 10.1021/acs.biochem.5b01173.

40. Manásková, S.H., Nazmi, K., van ’t Hof, W., van Belkum, A., Martin, N.I., Bikker, F.J., van Wamel, W.J.B., Veerman, E.C.I. (2016) Staphylococcus aureus Sortase A-Mediated Incorporation of Peptides: Effect of Peptide Modification on Incorporation. PLoS ONE, 11, e0147401. DOI: 10.1371/journal.pone.0147401.

39.  Koopmans, T., Wood, T.M., ‘t Hart, P., Kleijn, L.H.J., Hendrickx, A.P.A., Willems, R.J.L., Breukink, E., *Martin, N.I. (2015) Semisynthetic lipopeptides derived from nisin display antibacterial activity and lipid II-binding on par with that of the parent compound.Journal of the American Chemical Society137, 9382–9389. DOI: 10.1021/jacs.5b04501.

38. van Haren, M., Quarles van Ufford, L., Moret, E.E., *Martin, N.I. (2015) Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites. Organic and Biomolecular Chemistry, 13, 549-560. DOI: 10.1039/C4OB01734J.

37.  Corradini, E., Klaasse, G., Leurs, U., Heck, A.J.R., *Martin, N.I., *Scholten, A. (2015) Charting the interactome of PDE3A in human cells using an IBMX based chemical proteomics approach. Molecular Biosystems, 11, 2786-2797.DOI: 10.1039/C5MB00142K.

36.  Oude Blenke, E., Klaasse, G., Merten, H., Plückthun, A.,  Mastrobattista, E., *Martin, N.I. (2015) Liposome functionalization with copper-free “Click Chemistry”. Journal of Controlled Release202, 14-20. DOI: 10.1016/j.jconrel.2015.01.027.

35. Oppedijk, S.F., Martin, N.I. Breukink, E. (2015) Hit ‘em where it hurts: the growing and structurally diverse family of peptides that target lipid-IIBiochimica et Biophysica Acta. Biomembranes, DOI: 10.1016/j.bbamem.2015.10.024.

34. Gruba, N., Wysocka, M., Brzezinska, M., Debowski, D., Rolka, K., Martin, N.I., Lesner, A. (2015) Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome. Analytical Biochemistry, DOI: 10.1016/j.ab.2015.08.019.

33. Thomas, D., Koopmans, T., Lakowski, T.M., Kreinin, H., Bui, J.M., Vhuiyan, M.I.,*Martin, N.I., *Frankel, A. (2014) Protein arginine N-methyltransferase substrate preferences for different N(eta)-substituted arginyl peptides. ChemBioChem, 15, 1607-1613. DOI: 10.1002/cbic.201402045. (denotes equal authorship)

32. Mooney, C.A., Johnson, S.A., ‘t Hart, P., Quarles van Ufford, L., de Haan, C.A.M., Moret, E.E., *Martin, N.I. (2014) Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors. Journal of Medicinal Chemistry57, 3154-3160. DOI: 10.1021/jm401977j. (denotes equal authorship)

31. Mohammadi, T., Sijbrandi, R., Lutters, M., Verheul, J., Martin, N.I., den Blaauwen, T., de Kruijff, B., Breukink, E. (2014) Specificity of the transport of lipid II by FtsW inEscherichia coliThe Journal of Biological Chemistry289, 14707-14718. DOI: 10.1074/jbc.M114.557371.

30. ‘t Hart P., Kleijn, L.H.J., de Bruin, G., Oppedijk, S.F., Kemmink, J., *Martin, N.I.(2014) A combined solid- and solution-phase approach provides convenient access to analogues of the calcium-dependent lipopeptide antibiotics. Organic and Biomolecular Chemistry12, 913-918. Manuscript designated as an “OBC Hot Article” for month of January 2014DOI: 10.1039/C3OB42238K. (denotes equal authorship)

29. Dekker, F.J., van den Bosch, T., Martin, N.I. (2014) Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases.Drug Discovery Today19, 654-660. DOI: 10.1016/j.drudis.2013.11.012.

28.  van Wandelen, L., van Ameijde, J., Ismail-Ali, A., Quarles van Ufford, L., Vijftigschild, L., Beekman, J., Martin, N.I., Ruijtenbeek, R., Liskamp, R.M.J. (2013) Cell-penetrating bisubstrate-based protein kinase C inhibitors. ACS Chemical Biology8, 1479-1487.DOI: 10.1021/cb300709g.

27.  Kooij, R., Branderhorst, H.M., Bonte, S., Wieclawska, S., *Martin, N.I., *Pieters, R.J. (2013) Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives. MedChemComm4, 387-393. DOI: 10.1039/C2MD20343J.

26.  Koopmans, T., van Haren, M., Quarles van Ufford, L., Beekman, J., *Martin N.I. (2013) A concise preparation of the fluorescent amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine and extension of its utility in solid phase peptide synthesis. Bioorganic and Medicinal Chemistry21, 553-559. DOI: 10.1016/j.bmc.2012.10.055.

25. Van Hattum, H., Martin, N.I., Ruijtenbeek, R., Pieters, R.J. (2013) Development of a microarray detection method for galectin cancer proteins based on ligand binding.Analytical Biochemistry434, 99-104. DOI: 10.1016/j.ab.2012.11.003.

24.  Kleijn, L.H.J., Müskens, F.M., Oppedijk, S.F., de Bruin, G., *Martin, N.I. (2012) A concise preparation of the non-proteinogenic amino acid L-kynurenine. Tetrahedron Letters53, 6430-6432. DOI: 10.1016/j.tetlet.2012.09.055.

23. ‘t Hart P., Thomas, D., van Ommeren, R., Lakowski, T.M., *Frankel, A., *Martin, N.I. (2012) Analogues of the HIV-Tat peptide containing Nη-modified arginines as potent inhibitors of protein arginine N-methyltransferases. MedChemComm, 3, 1235-1244. DOI: 10.1039/C2MD20161E. (denotes equal authorship)

22. Koopmans, T., Dekker, F.J., *Martin, N.I. (2012) A photocleavable affinity tag for the enrichment of alkyne-modified biomolecules. RSC Advances2, 2244-2246. DOI: 10.1039/C2RA20082A.

21. ‘t Hart P, Lakowski, T.M., Thomas, D., *Frankel, A., *Martin, N.I. (2011) Peptidic partial-bisubstrates as inhibitors of the protein arginine N-methyltransferases. ChemBioChem, 12, 1427-1432. DOI: 10.1002/cbic.201100074. (denotes equal authorship)

20. Olrichs, N.K., Aarsman, M.E.G., Verheul, J. Arnusch, C.J., Martin, N.I., Herve, M., Vollmer, W., de Kruijff, B., Breukink, E., den Blaauwen, T.A. (2011) A novel in vivo cell-wall labeling approach sheds new light on peptidoglycan synthesis in Escherichia coli.ChemBioChem, 12, 1124-1133. DOI: 10.1002/cbic.201000552.

19. Lakowski, T.M., ‘t Hart P. Ahern, C.A. *Martin, N.I., *Frankel, A. (2010) Nη-Substituted arginyl peptide inhibitors of protein arginine N-methyltransferases. ACS Chemical Biology5, 1053-1063. DOI: 10.1021/cb100161u. (denotes equal authorship)

18. *Martin, N.I. (2009) Concise preparation of tetra-orthogonally protected (2S,6R)-lanthionines. The Journal of Organic Chemistry74, 946-949. DOI: 10.1021/jo802415c.

17. Woodward, J.J., Chang, M.M., Martin, N.I. and Marletta, M.A. (2009) The second step of the nitric oxide synthase reaction: evidence for ferric-peroxo as the active oxidant. Journal of the American Chemical Society131, 297-305. DOI: 10.1021/ja807299t.

16. Martin, N.I., Woodward, J.J., Winter, M.B., and Marletta, M.A. (2009) 4,4-Difluorinated analogues of L-arginine and NG-hydroxy-L-arginine as mechanistic probes for nitric oxide synthase. Bioorganic and Medicinal Chemistry Letters, 19, 1758-1762. DOI: 10.1016/j.bmcl.2009.01.076.

15. *Martin, N.I. and Liskamp, R.M.J. (2008) Preparation of NG-substituted L-arginine analogues suitable for solid phase peptide synthesis. The Journal of Organic Chemistry,73, 7849-7851. DOI: 10.1021/jo801517f.

14. Martin, N.I., Beeson, W.T., Woodward, J.J. and Marletta, M.A. (2008) NG-Aminoguanidines from primary amines and the preparation of nitric oxide synthase inhibitors. Journal of Medicinal Chemistry, 51, 924-931. DOI: 10.1021/jm701119v.

13. Martin, N.I., Woodward, J.J., Winter, M.B., Beeson, W.T. and Marletta, M.A. (2007) Design and synthesis of C5 methylated L-arginine analogues as active site probes for nitric oxide synthase. Journal of the American Chemical Society, 129, 12563-12570. DOI: 10.1021/ja0746159.

12. Martin, N.I. and Breukink, E. (2007) The expanding role of lipid II as a target for lantibiotics. Future Microbiology2, 513-525. DOI: 10.2217/17460913.2.5.513.

11. Woodward, J.J., Martin, N.I. and Marletta, M.A. (2007) An Escherichia coli expression-based method for heme Substitution. Nature Methods4, 43-45. DOI: 10.1038/nmeth984.

10. Martin, N.I., Derbyshire, E.R. and Marletta, M.A. (2007) Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. Bioorganic and Medicinal Chemistry Letters, 17. 4938-4941. DOI: 10.1016/j.bmcl.2007.06.039.

9. Pattabiraman, V.R., Stymiest, J.L., Derksen, D.J., Martin, N.I. and Vederas, J.C. (2007) Multiple on-resin olefin metathesis to form ring expanded analogues of the lantibiotic peptide, lacticin 3147 A2. Organic Letters, 9. 699-702. DOI: 10.1021/ol063133j.

8. *Martin, N.I., Woodward, J.J. and Marletta, M.A. (2006) NG-Hydroxyguanidines from primary amines. Organic Letters, 8. 4035-4036. Paper featured on the organic chemistry web portal (www.organic-chemistry.org). DOI: 10.1021/ol061454p.

7. Gursky, L.J., Martin, N.I., Derksen, D.J., van Belkum, M.J., Kaur, K., Vederas, J.C., Stiles, M.E. and McMullen, L.M. (2006) Production of piscicolin 126 by Carnobacterium maltaromaticum UAL26 is controlled by temperature and induction peptide concentration. Archives of Microbiology186, 317-325. DOI: 10.1007/s00203-006-0147-z.

6. Martin, N.I., Sprules, T., Carpenter, M.R., Cotter, P.D., Hill, C., Ross, R.P. and Vederas, J.C. (2004) Characterization of lacticin 3147, A two-peptide antibiotic with synergistic activity. Biochemistry43, 3049-3056. DOI: 10.1021/bi0362065.

5. Martin, N.I., Hu, H., Moake, M.M., Churey, J.J., Whittal, R., Worobo, R.W. and Vederas, J.C. (2003) Isolation, structural characterization and properties of mattacin (polymyxin M), a cyclic peptide antibiotic produced by Paenibacillus kobensis MJournal of Biological Chemistry278, 13124 – 13132. DOI: 10.1074/jbc.M212364200.

4. Garneau, S., Martin, N.I. and Vederas, J.C. (2002) Two-peptide bacteriocins produced by lactic acid bacteria. Biochimie84, 577-592. DOI: 10.1016/S0300-9084(02)01414-1.

3. Ramtohul, Y.K., Martin, N.I., Silkin, L., James, M.N.H. and Vederas, J.C. (2002) Synthesis of pseudoxazolones and their inhibition of the 3C cysteine proteinases from hepatitis A virus and human rhinovirus-14. Journal of the Chemical Society. Perkin Transactions 1. 1351-1359. DOI: 10.1039/B202643K.

2. Ramtohul, Y.K., Martin, N.I., Silkin, L., James, M.N.G. and Vederas, J.C. (2001) Pseudoxazolones, a new class of inhibitors for cysteine proteinases: Inhibition of hepatitis A virus and human rhinovirus 3C proteinases. Journal of the Chemical Society Chemical Communications. 2740-2741. DOI: 10.1039/B109095J.

1. Mahaffy, P.G., Martin, N.I., Newman, K.E., Hohn, B., Mikula, R.J. and Munoz, V.A. (1998) A novel matrix for non-intrusive environmental lead screening. Environmental Science and Technology32, 2467-2477. DOI: 10.1021/es970699h.

 

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Gegenereerd op 2017-09-23 02:15:47
Additional functions and activities

• Journal reviewer for: ACS Chem. Biol., ACS Infect. Dis., Angew. Chem. Int. Ed., Bioorg. Med. Chem. Lett., ChemBioChem, J. Med. Chem., J. Org. Chem., J. Peptide Sci., MedChemComm, Org. Biomol. Chem., Org. Lett., Science, Synlett., Tetrahedron Lett. 

• Management Committee Member for EU COST action CM1406 “Epigenetic Chemical Biology”

• Member of the Dutch Science Foundation (NWO) study group on Medicinal Chemisty

• Co-organizer of the annual Dutch Peptide Symposium

• Co-founder of Karveel Pharmaceuticals (www.karveel.com)

 

 

 

 

 

Gegenereerd op 2017-09-23 02:15:47
Full name
dr. N.I. Martin Contact details
David de Wiedgebouw

Universiteitsweg 99
Room 5.64
3584 CG  UTRECHT
The Netherlands


Phone number (direct) +31 61 878 5274

 

 

 

 

 

 

 

 

Gegenereerd op 2017-09-23 02:15:47
Last updated 24.03.2017