prof. dr. R.J. (Rob J.) de Boer
R.J.deBoer@uu.nl
Gegenereerd op 2018-06-25 16:12:51


Chair
Theoretical Biology
Profile

The immune system is a fascinating complex system taking decisions on how to respond to a wide variety of stimuli, varying from lethal pathogens to harmless proteins in the food. Decisions are remembered for life in the form of immunological memory. Most of the research in immunology is of a qualitative nature, describing novel cell types, molecules, and genes. The proper understanding of such a complex systems also requires a more quantitative approach describing the various population sizes, the turnover rates of the cells within each population, their migration rates, and the rates at which cells form contacts with other cells.

A major part of our work is to develop a more quantitative immunology by describing the population dynamics of its major populations using a variety of labeling techniques and mathematical modeling to analyze the data. Using deuterium labeling we estimate the expected life span of naïve and memory T cells in volunteers and HIV infected patients, finding that long-lived immunological memory is maintained by short-lived cells, and that HIV infecting increases cellular turnover rates. We aim to quantify the daily number of target cells that one cytotoxic T cell can kill per day.

Using a variety of modeling techniques we analyze 2-photon microscopy data to quantify the migration of T cells in lymphoid tissue and within the skin of mice.  We estimate the true long contact times required to stimulated naïve T cells from short videos, and find evidence for directed migration of cytotoxic T cells in peripheral tissues.

Pathogens are also fascinating complex systems that by their faster evolution manage to exploit properties of the immune system to elicit inappropriate immune reactions. We study host-pathogen evolution by in silico evolution models. We study the evolution of polymorphism in the antigen presentation pathway and of the KIR molecules on natural killer cells.  Recently we started to study the evolution and epidemiology of pathogens that are adapting each unique immune system of their massively heterogeneous hosts.

For more information, visit the website at http://tbb.bio.uu.nl/rdb

Involved in the following study programme(s)
Scientific expertise
theoretical immunology
Gegenereerd op 2018-06-25 16:12:51
All publications
  2017 - Scholarly publications
Gadhamsetty, Saikrishna, Marée, Athanasius F M, Beltman, Joost B & de Boer, Rob J (2017). A Sigmoid Functional Response Emerges When Cytotoxic T Lymphocytes Start Killing Fresh Target Cells. Biophysical Journal, 112 (6), (pp. 1221-1235) (15 p.). Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved..
Müller, Viktor, de Boer, Rob J, Bonhoeffer, Sebastian & Szathmáry, Eörs (26.07.2017). An evolutionary perspective on the systems of adaptive immunity. Biological Reviews © 2017 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society..
de Visser, Lenneke, H de Boer, Joke, T Rijkers, Ger, Wiertz, Karin, van den Ham, Henk-Jan, de Boer, Rob, M van Loon, Anton, Rothova, Aniki & de Groot-Mijnes, Jolanda D F (01.04.2017). Cytokines and Chemokines Involved in Acute Retinal Necrosis. Investigative Ophthalmology and Visual Science, 58 (4), (pp. 2139-2151) (13 p.).
van Hoeven, Vera, Drylewicz, Julia, Westera, Liset, den Braber, Ineke, Mugwagwa, Tendai, Tesselaar, Kiki & de Boer, Rob J (2017). Dynamics of Recent Thymic Emigrants in Young Adult Mice. Frontiers in Immunology, 8.
De Boer, Rob J & Perelson, Alan S (06.09.2017). How germinal centers evolve broadly neutralizing antibodies - the breadth of the follicular helper T cell response. Journal of Virology Copyright © 2017 American Society for Microbiology..
Carrillo-Bustamante, Paola, de Boer, Rob J & Kesmir, Can (10.07.2017). Specificity of inhibitory KIRs enables NK cells to detect changes in an altered peptide environment. Immunogenetics
Gadhamsetty, Saikrishna, Marée, Athanasius F M, de Boer, Rob J & Beltman, Joost B (2017). Tissue Dimensionality Influences the Functional Response of Cytotoxic T Lymphocyte-Mediated Killing of Targets. Frontiers in Immunology, 7, (pp. 1-12) (12 p.).
  2016 - Scholarly publications
Asquith, Becca & de Boer, Rob J (16.12.2016). How lymphocytes add up. Nature Immunology, 18 (1), (pp. 12-13) (2 p.).
Woolthuis, Rutger G, van Dorp, Christiaan H, Kesmir, Can, de Boer, Rob J & van Boven, Michiel (15.09.2016). Long-term adaptation of the influenza A virus by escaping cytotoxic T-cell recognition. Scientific Reports, 6, (pp. 1-8) (8 p.).
Gadhamsetty, Saikrishna, Coorens, Tim & de Boer, Rob J (2016). Notwithstanding circumstantial alibis, cytotoxic T cells can be major killers of HIV-1 infected cells. Journal of Virology, 90 (16), (pp. 7066-7083). Copyright © 2016 Gadhamsetty et al..
Ikeda, Hiroki, Nakaoka, Shinji, de Boer, Rob J, Morita, Satoru, Misawa, Naoko, Koyanagi, Yoshio, Aihara, Kazuyuki, Sato, Kei & Iwami, Shingo (2016). Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model. Retrovirology, 13.
Drylewicz, Julia, Vrisekoop, Nienke, Mugwagwa, Tendai, de Boer, Anne Bregje, Otto, Sigrid A, Hazenberg, Mette D, Tesselaar, Kiki, de Boer, Rob J & Borghans, José A M (2016). Reconciling Longitudinal Naive T-Cell and TREC Dynamics during HIV-1 Infection. PLoS One, 11 (3).
Gerritsen, Bram, Pandit, Aridaman, Andeweg, Arno C & de Boer, Rob J (2016). RTCR - a pipeline for complete and accurate recovery of T cell repertoires from high throughput sequencing data. Bioinformatics, 32 (20), (pp. 3098-3106) (9 p.). © The Author 2016. Published by Oxford University Press..
Olde Rikkert, Marcel G M, Dakos, Vasilis, Buchman, Timothy G, Boer, Rob de, Glass, Leon, Cramer, Angélique O J, Levin, Simon, van Nes, Egbert, Sugihara, George, Ferrari, Michel D, Tolner, Else A, van de Leemput, Ingrid, Lagro, Joep, Melis, René & Scheffer, Marten (2016). Slowing Down of Recovery as Generic Risk Marker for Acute Severity Transitions in Chronic Diseases. Critical Care Medicine, 44 (3), (pp. 601-6) (6 p.).
Carrillo-Bustamante, Paola, Kesmir, C. & de Boer, Rob J (2016). The evolution of natural killer cell receptors. Immunogenetics, 68 (1), (pp. 3-18).
Textor, Johannes, Mandl, Judith N & de Boer, Rob J (2016). The Reticular Cell Network - A Robust Backbone for Immune Responses. PLoS Biology, 14 (10).
  2015 - Scholarly publications
Carrillo-Bustamante, Paola, Kesmir, C. & de Boer, Rob J (2015). A Coevolutionary Arms Race between Hosts and Viruses Drives Polymorphism and Polygenicity of NK Cell Receptors. Molecular Biology and Evolution, 32 (8), (pp. 2149-2160) (12 p.). © The Author 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution..
Carrillo-Bustamante, Paola, Kesmir, Can & de Boer, Rob J (2015). Can Selective MHC Downregulation Explain the Specificity and Genetic Diversity of NK Cell Receptors?. Frontiers in Immunology, 6, (pp. 311). This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
de Boer, R.J. (13.05.2015) Invited speaker 22th International HIV Dynamics and Evolution Budapest (13.05.2015 - 16.05.2015) Can we estimate the rate at which HIV-1 infected cells are killed? (organizer: V. Muller)
Niculescu, Ioana, Textor, Johannes & de Boer, Rob J (2015). Crawling and Gliding - A Computational Model for Shape-Driven Cell Migration. PLoS Computational Biology, 11 (10) (22 p.).
Pandit, Aridaman & de Boer, Rob J (2015). HIV-1 CCR5 gene therapy will fail unless it is combined with a suicide gene. Scientific Reports, 5.
de Boer, R.J. (27.07.2015) Invited speaker Visit group Alan Perelson Los Alamos (27.07.2015) How much do CTL contribute to the death of HIV-1 infected cells? (organizer: A.S. Perelson)
de Boer, R.J. (04.06.2015) Invited speaker Modelling the immune response to infection (BSI) Cambridge (04.06.2015 - 05.06.2015) How much do CTL contribute to the death of HIV-1 infected cells? (organizers: T. Laws and B. Asquith)
de Boer, R.J. (14.04.2015) Keynote speaker Jaroslav Stark Memorial Lecture London (14.04.2015) Immune-Epidemiological modeling of HIV-1 infections. (organizer: M. Sternberg).
de Boer, R.J. (07.08.2015) Invited speaker Bio-Modeling Workshop Los Alamos (07.08.2015) Immuno-epidemiological Modeling of HIV-1 Predicts High Heritability of the Set-Point Virus Load, while Selection for CTL Escape Dominates Virulence Evolution. (organizer: R. Ribeiro)
de Boer, R.J. (24.07.2015) Invited speaker 10th q-bio summerschool Albequerque (24.07.2015) Invited lecturer, Interpreting and Quantifying T cell migration data. (organizers: B. Hlavaceck and R. Ribeiro)
de Boer, R.J. (07.07.2015) Invited speaker QBio Summerschool Utrecht (06.07.2015 - 10.07.2015) Invited lecturer. What do we learn from quantifying the immune responses to HIV? (organizer: R.J. de Boer)
Westera, Liset, van Hoeven, Vera, Drylewicz, Julia, Spierenburg, Gerrit, van Velzen, Jeroen F., de Boer, Rob J., Tesselaar, Kiki & Borghans, José A M (01.04.2015). Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover. Aging Cell, 14 (2), (pp. 219-227) (9 p.).
de Boer, R.J. (29.07.2015) Invited speaker Motility in the Immune System: From Microscopic Movement to Macro- scopic Function Santa Fe (29.07.2015 - 30.07.2015)
Saeki, Koichi, Doekes, Hilje M. & De Boer, Rob J. (01.06.2015). Optimal T cell cross-reactivity and the role of regulatory T cells. Journal of Theoretical Biology, 375, (pp. 4-12) (9 p.).
de Boer, R.J. (01.01.2015 01.08.2015) Member QBio Summerschool (Event) Organizer
Vrisekoop, Nienke, Drylewicz, Julia, Van Gent, Rogier, Mugwagwa, Tendai, Van Lelyveld, Steven, Veel, Ellen, Otto, Sigrid A, Ackermans, Mariëtte T, Vermeulen, Joost N, Huidekoper, Hidde H, Prins, Jan M, Miedema, Frank, de Boer, Rob J, Tesselaar, Kiki & Borghans, José A M (24.07.2015). Quantification of naive and memory T-cell turnover during HIV-1 infection. AIDS, 29 (16), (pp. 2071–2080).
Ahmed, Raya, Westera, Liset, Drylewicz, Julia, Elemans, Marjet, Zhang, Yan, Kelly, Elizabeth, Reljic, Rajko, Tesselaar, Kiki, de Boer, Rob J, Macallan, Derek C, Borghans, José A M & Asquith, Becca (2015). Reconciling Estimates of Cell Proliferation from Stable Isotope Labeling Experiments. PLoS Computational Biology, 11 (10), (pp. e1004355).
de Boer, R.J. (02.02.2015) Invited speaker Visit group F. Allgower Stuttgart (02.02.2015) Slow evolution of immune escapes during chronic HIV infection. (organizer: F. Allgower)
Ariotti, Silvia, Beltman, Joost B, Borsje, Rianne, Hoekstra, Mirjam E, Halford, William P, Haanen, John B A G, de Boer, Rob J & Schumacher, Ton N M (01.12.2015). Subtle CXCR3-Dependent Chemotaxis of CTLs within Infected Tissue Allows Efficient Target Localization. Journal of Immunology, 195 (11), (pp. 5285-95) (11 p.). Copyright © 2015 by The American Association of Immunologists, Inc..
Perié, Leïla, Duffy, Ken R, Kok, Lianne, de Boer, Rob J & Schumacher, Ton N (17.12.2015). The Branching Point in Erythro-Myeloid Differentiation. Cell, 163 (7), (pp. 1655-62) (8 p.). Copyright © 2015 Elsevier Inc. All rights reserved..
Gadham Setty, S., Beltman, Joost B. & de Boer, Rob J. (01.11.2015). What do mathematical models tell us about killing rates during HIV-1 infection?. Immunology Letters, 168 (1), (pp. 1-6) (6 p.).
  2014 - Scholarly publications
Gadham Setty, S., Marée, Athanasius F M, Beltman, Joost B & de Boer, Rob J (15.04.2014). A general functional response of cytotoxic T lymphocyte-mediated killing of target cells. Biophysical Journal, 106 (8), (pp. 1780-1791) (12 p.).
Perié, Leïla, Hodgkin, Philip D, Naik, Shalin H, Schumacher, Ton N, de Boer, Rob J & Duffy, Ken R (27.02.2014). Determining lineage pathways from cellular barcoding experiments. Cell Reports, 6 (4), (pp. 617-624) (8 p.). Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved..
de Boer, R.J. () Invited speaker Modelling Infectious Diseases Coorg (23.11.2014 - 03.12.2014) Host Pathogen Interactions: bridging Immunology & Epidemiology
van Dorp, Christiaan H, van Boven, Michiel & de Boer, Rob J (2014). Immuno-epidemiological modeling of HIV-1 predicts high heritability of the set-point virus load, while selection for CTL escape dominates virulence evolution. PLoS Computational Biology, 10 (12), (pp. e1003899).
Ikeda, Hiroki, De Boer, Rob J., Sato, Kei, Morita, Satoru, Misawa, Naoko, Koyanagi, Yoshio, Aihara, Kazuyuki & Iwami, Shingo (21.05.2014). Improving the estimation of the death rate of infected cells from time course data during the acute phase of virus infections - Application to acute HIV-1 infection in a humanized mouse model. Theoretical Biology and Medical Modelling, 11.
de Boer, R.J. (01.01.2014) Member QBio Summer School (Event) Organizer<br/><br/>Organizer
Carrillo-Bustamante, Paola, Kesmir, Can & de Boer, Rob J. (01.01.2014). Quantifying the Protection of Activating and Inhibiting NK Cell Receptors during Infection with a CMV-Like Virus. Frontiers in Immunology, 5 (14 p.).
de Boer, R.J. () Invited speaker Quantitative Immunology, Les Houches, France Les Houches (09.03.2014 - 14.03.2014)
Textor, Johannes, Henrickson, Sarah E, Mandl, Judith N, von Andrian, Ulrich H, Westermann, Jürgen, de Boer, Rob J & Beltman, Joost B (2014). Random migration and signal integration promote rapid and robust T cell recruitment. PLoS Computational Biology, 10 (8) (16 p.).
de Boer, R.J. (14.07.2014) Invited speaker QBio Summer School Utrecht (14.07.2014 - 18.07.2014) What do we learn from quantifying the immune responses to HIV?
  2013 - Scholarly publications
Schittler, D., Allgöwer, F. & de Boer, R.J. (2013). A new model to simulate and analyze proliferating cell populations in BrdU labeling experiments. BMC Systems Biology, 7 (Suppl. 1), (pp. S4) (1 p.).
Textor, J.C., Sinn, M. & de Boer, R.J. (2013). Analytical results on the Beauchemin model of lymphocyte migration. BMC Bioinformatics, 14, (pp. S10) (1 p.).
de Boer, R.J. & Perelson, A.S. (2013). Antigen-stimulated CD4 T cell expansion can be limited by their grazing of peptide-MHC complexes. Journal of Immunology, 190, (pp. 5454-5458) (5 p.).
Westera, Liset, Drylewicz, Julia, den Braber, Ineke, Mugwagwa, Tendai, van der Maas, Iris, Kwast, Lydia, Volman, Thomas, van de Weg-Schrijver, Elise H R, Bartha, István, Spierenburg, Gerrit, Gaiser, Koos, Ackermans, Mariëtte T, Asquith, Becca, de Boer, Rob J, Tesselaar, Kiki & Borghans, José A M (26.09.2013). Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans. Blood, 122 (13), (pp. 2205-2212) (8 p.).
Rao, X, de Boer, R.J., van Baarle, D., Maiers, M. & Kesmir, C. (2013). Complementarity of Binding Motifs is a General Property of HLA-A and HLA-B Molecules and Does Not Seem to Effect HLA Haplotype Composition. Frontiers in Immunology, 4, (pp. 374) (1 p.).
Naik, S.H., Perie, L., Swart, E., Gerlach, C., van Rooij, N., de Boer, R.J. & Schumacher, T.N. (2013). Diverse and heritable lineage imprinting of early haematopoietic progenitors. Nature
van den Ham, H.J., Waal, L., Zaaraoui-Boutahar, F., Bijl, M., van IJcken, W., Osterhaus, A.D., de Boer, R.J. & Andeweg, A.C. (2013). Early divergence of Th1 and Th2 transcriptomes involves a small core response and sets of transiently expressed genes. European Journal of Immunology, 43 (4), (pp. 1074-84) (11 p.).
Gerlach, C., Rohr, J.C., Perie, L., van Rooij, N., Heijst, J.W., Velds, A., Urbanus, J., Naik, S.H., Jacobs, H., Beltman, J.B., de Boer, R.J. & Schumacher, T.N. (2013). Heterogeneous differentiation patterns of individual CD8+ T cells. Science, 340, (pp. 635-639) (5 p.).
Miedema, F., Hazenberg, M., Tesselaar, K., van Baarle, D., de Boer, R.J. & Borghans, J.A.M. (2013). Immune activation and collateral damage in aids pathogenesis. Frontiers in Immunology, 4, (pp. 298) (1 p.).
van den Ham, H.J., Andeweg, A.C. & de Boer, R.J. (2013). Induction of appropriate Th cell phenotypes: cellular decision-making in heterogeneous environments. Parasite Immunology
van Berkel, K., de Boer, R.J., Scheres, B.J.G. & ten Tusscher, K.H.W.J. (2013). Polar auxin transport: models and mechanisms. Development, 140, (pp. 2253-2268) (16 p.).
de Boer, R.J. & Perelson, A.S. (2013). Quantifying T lymphocyte turnover. Journal of Theoretical Biology, 327, (pp. 45-87) (43 p.).
van Deutekom, H.W.M., Wijnker, G. & de Boer, R.J. (2013). The rate of immune excape vanishes when multiple immune responses control an HIV infection. Journal of Immunology, 191, (pp. 3277-3286) (10 p.).
Carrillo Bustamante, N.P., Kesmir, C. & de Boer, R.J. (2013). Virus encoded MHC-like decoys diversity the inhibitory KIR repertoire. PLoS Computational Biology, 9 (10), (pp. e1003264) (1 p.).
  2012 - Scholarly publications
Baltcheva, I., Veel, E.M., Volman, T.J.H., Koning, D., Brouwer, A.I., Le Boudec, J.Y., Tesselaar, N.A., de Boer, R.J. & Borghans, J.A.M. (2012). A Generalized Mathematical Model To Estimate T- and B-Cell Receptor Diversities Using AmpliCot. Biophysical Journal, 103 (5), (pp. 999-1010) (12 p.).
Ganusov, V.V. & de Boer, R.J. (2012). A mechanistic model for bromodeoxyuridine dilution naturally explains labelling data of self-renewing T cell populations. Journal of the Royal Society Interface
van den Ham, H.J. & de Boer, R.J. (2012). Cell division curtails helper phenotype plasticity and expedites helper T-cell differentiation. Immunology and Cell Biology, 90, (pp. 860-868) (9 p.).
Vroomans, C., Maree, A.F.M., de Boer, R.J. & Beltman, J.B. (2012). Chemotactic migration of T cells towards dendritic cells promotes the detection of rare antigens. PLoS Computational Biology, 8, (pp. e1002763) (1 p.).
Calis, J.J.A., de Boer, R.J. & Kesmir, C. (2012). Degenerate T-cell recognition of peptides on MHC molecules creates large holes in the T-cell repertoire. PLoS Computational Biology, 8 (3), (pp. e1002412).
Iwami, S., Sato, K., de Boer, R.J., Aihara, K., Miura, T. & Koyanagi, Y. (2012). Identifying viral parameters from in vitro cell cultures. Frontiers of biology, 3, (pp. 319-319) (1 p.).
Althaus, C.L. & de Boer, R.J. (2012). Impaired immune evation in HIV through intracellular delays and multiple infection of cells. Proceedings of the Royal Society B: Biological Sciences, 279, (pp. 3003-3010) (8 p.).
den Braber, A.J., Mugwagwa, T., Vrisekoop, N., Westera, L., Mögling, R, de Boer, A.B., Willems, N., Schrijver, E.H.R., Spierenburg, G.Th., Gaiser, J.F., Mul, E., Otto, S.A., Ruiter, A.F., Ackermans, M.T., Miedema, F., Borghans, J.A.M., de Boer, R.J. & Tesselaar, N.A. (2012). Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans. Immunity, 36 (2), (pp. 288-297) (10 p.).
de Boer, R.J., Perelson, A.S. & Ribeiro, R.M. (2012). Modelling deuterium labelling of lymphocytes with temporal and/or kinetic heterogeneity. Journal of Theoretical Biology, 9, (pp. 2191-2299) (109 p.).
Ariotti, S., Beltman, J.B., Chodaczek, G., Hoekstra, M.E., van Beek, A.E., Gomez-Eerland, R., Ritsma, L., van Rheenen, J.E., Maree, A.F.M., Zal, T., de Boer, R.J., Haanen, J.B. & Schumacher, T.N. (2012). Tissue-resident memory CD8+ cells continuously patrol skin epithelia to quickly recognize local antigen. Proceedings of the National Academy of Sciences of the United States of America, 109, (pp. 19739-19744) (6 p.).
  2011 - Scholarly publications
Beltman, J.B., Allen, C.D., Cyster, J.G. & de Boer, R.J. (2011). B cells within germinal centers migrate preferentially from dark to light zone. Proceedings of the National Academy of Sciences of the United States of America, 108, (pp. 8755-8760) (6 p.).
Althaus, C.L. & de Boer, R.J. (2011). Implications of ctl-mediated killing of hiv-infected cells during the non-productive stage of infection. PLoS One, 6, (pp. e16468) (1 p.).
Ganusov, V.V., Barber, D.L. & de Boer, R.J. (2011). Killing of targets by CD8+ T cells in the mouse spleen follows the law of mass action. PLoS One, 6, (pp. e15959) (1 p.).
Pillay, J., den Braber, A.J., Vrisekoop, N., Kwast, L.M., de Boer, R.J., Borghans, J.A.M. & Tesselaar, N.A. (2011). Response: The in vivo half-life of human neutrophils. Blood, 117 (22), (pp. 6053-6054) (2 p.).
  2010 - Scholarly publications
de Boer, R.J., Ribeiro, R.M. & Perelson, A.S. (2010). Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissue. PLoS Computational Biology, 6, (pp. e1000906) (1 p.).
De Boer, Rob J, Ribeiro, Ruy M & Perelson, Alan S (2010). Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues. PLoS Computational Biology, 6 (9), (pp. e1000906).
Ganusov, V.V., Borghans, J.A.M. & de Boer, R.J. (2010). Explicit kinetic heterogeneity: mathematical models for interpretation of deuterium labeling of heterogeneous cell populations. PLoS Computational Biology, 6 (2), (pp. e1000666) (1 p.).
van den Ham, H J, de Waal, L, Andeweg, A C & de Boer, R J (30.09.2010). Identification of helper T cell master regulator candidates using the polar score method. Journal of Immunological Methods, 361 (1-2), (pp. 98-109) (12 p.). Copyright © 2010 Elsevier B.V. All rights reserved..
Lyadova, Irina V, Tsiganov, Evgeny N, Kapina, Marina A, Shepelkova, Galena S, Sosunov, Vasily V, Radaeva, Tatiana V, Majorov, Konstantin B, Shmitova, Natalya S, van den Ham, Henk-Jan, Ganusov, Vitaly V, De Boer, Rob J, Racine, Rachael & Winslow, Gary M (2010). In mice, tuberculosis progression is associated with intensive inflammatory response and the accumulation of Gr-1 cells in the lungs. PLoS One, 5 (5), (pp. e10469) (1 p.).
Pillay, J., den Braber, I., Vrisekoop, N., Kwast, L.M., de Boer, R.J., Borghans, J.A.M., Tesselaar, K. & Koenderman, L. (2010). In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days. Blood, 116 (4), (pp. 625-627) (3 p.).
Althaus, Christian L & De Boer, Rob J (2010). Intracellular transactivation of HIV can account for the decelerating decay of virus load during drug therapy. Molecular Systems Biology, 6, (pp. 348) (1 p.).
Engram, J.C., Cervasi, B., Borghans, J.A.M., Klatt, N.R., Gordon, S.N., Chahroudi, A., Else, J.G., Mittler, R.S., Sodora, D.L., de Boer, R.J., Brenchley, J.M., Silvestri, G. & Paiardini, M. (2010). Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates. Blood, 116 (5), (pp. 748-758) (11 p.).
Schmid, B V, Kęsmir, C & de Boer, R J (2010). Quantifying how MHC polymorphism prevents pathogens from adapting to the antigen presentation pathway. Epidemics, 2 (3), (pp. 99-108) (10 p.). Copyright © 2010 Elsevier B.V. All rights reserved..
  2009 - Scholarly publications
van den Ham, H.J., de Jager, W., Bijlsma, J.W.J., Prakken, A.B.J. & de Boer, R.J. (2009). Differential cytokine profiles in juvenile idiopathic arthritis subtypes revealed by cluster analysis. Rheumatology, 48 (8), (pp. 899-905) (7 p.).
Althaus, C.L., de Vos, A.S. & de Boer, R.J. (2009). Reassessing the human immunodeficiency virus type 1 life cycle through age-structured modeling: life span of infected cells, viral generation time, and basic reproductive number, R0. Journal of Virology, 83, (pp. 7659-7667) (9 p.).
Schmid, B.V., Kesmir, C. & de Boer, R.J. (2009). The distribution of CTL epitopes in HIV-1 appears to be random, and similar to that of other proteomes. BMC Evolutionary Biology, 9, (pp. 184) (1 p.).
Beltman, J.B., Henrickson, S.E., von Andrian, U.H., de Boer, R.J. & Maree, A.F.M. (2009). Towards estimating the true duration of dendritic cell interactions with T cells. Journal of Immunological Methods, 347, (pp. 54-69) (16 p.).
  2008 - Scholarly publications
Frankild, S., de Boer, R.J., Lund, O., Nielsen, M. & Kesmir, C. (2008). Amino acid similarity accounts for T cell cross-reactivity and for "holes" in the T cell repertoire. PLoS One, 3, (pp. e183).
Thomas-Vaslin, V., Altes, H.K., de Boer, R.J. & Klatzmann, D. (2008). Comprehensive assessment and mathematical modeling of T cell population dynamics and homeostasis. Journal of Immunology, 180, (pp. 2240-2250) (11 p.).
Althaus, C.L. & de Boer, R.J. (2008). Dynamics of immune escape during HIV/SIV infection. PLoS Computational Biology, 4, (pp. e1000103) (1 p.).
Ganusov, V.V. & de Boer, R.J. (2008). Estimating in vivo death rates of targets due to CD8 T-cell-mediated killing. Journal of Virology, 82, (pp. 11749-11757) (9 p.).
van den Ham, H.J. & de Boer, R.J. (2008). From the two-dimensional Th1 and Th2 phenotypes to high-dimensional models for gene regulation. International Immunology, 20, (pp. 1269-1277) (9 p.).
Vrisekoop, N., den Braber, I., de Boer, A.B., Ruiter, A.F.C., Ackermans, M.T., van der Crabben, S.N., Schrijver, E.H.R., Spierenburg, G.Th., Sauerwein, H.P., Hazenberg, M.D., de Boer, R.J., Miedema, F., Borghans, J.A.M. & Tesselaar, K. (2008). Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool. Proceedings of the National Academy of Sciences of the United States of America, 105 (16), (pp. 6115-6120) (6 p.).
Ribeiro, R.M. & de Boer, R.J. (2008). The contribution of the thymus to the recovery of peripheral naive T-cell numbers during antiretroviral treatment for HIV infection. Journal of Acquired Immune Deficiency Syndromes, 49, (pp. 1-8) (8 p.).
Severins, M., Borghans, J.A.M. & de Boer, R.J. (2008). The role of Th1/Th2 phenotypes in T cell Vaccination: Insights from a mathematical model. In J. Zhang & I.R. Cohen (Eds.), T-cell Vaccination (pp. 139-158) (20 p.). New York: Nova Biomedical Books.
Schmid, B.V., Kesmir, C. & de Boer, R.J. (2008). The specificity and polymorphism of the MHC class I prevents the global adaptation of HIV-1 to the monomorphic proteasome and TAP. PLoS One, 3, (pp. e3525) (1 p.).
Ganusov, V.V. & de Boer, R.J. (2008). Tissue distribution of lymphocytes and plasma cells and the role of the gut: response to Pabst et al. Trends in Immunology, 29, (pp. 209-210) (2 p.).
  2007 - Scholarly publications
de Boer, R.J. (2007) Editorial board member Biology Direct (Journal)
Ganusov, V.V. & de Boer, R.J. (2007). Do most lymphocytes in humans really reside in the gut. Trends in Immunology, 28, (pp. 514-518) (5 p.).
Althaus, C.L., Ganusov, V.V. & de Boer, R.J. (2007). Dynamics of CD8+ T cell responses during acute and chronic lymphocytic choriomeningitis virus infection. Journal of Immunology, 179, (pp. 2944-2951) (8 p.).
de Boer, R.J. (2007) Editorial board member Epidemics (Journal)
Borghans, J.A.M., Mølgaard, A., de Boer, R.J. & Kesmir, C. (2007). HLA alleles associated with slow progression to AIDS truly prefer to present HIV-1 p24. PLoS One, 2 (9), (pp. e920) (1 p.).
Ganusov, V.V., Milutinovic, D. & de Boer, R.J. (2007). IL-2 regulates expansion of CD4+ T cell populations by affecting cell death: insights from modeling CFSE data. Journal of Immunology, 179, (pp. 950-957) (8 p.).
de Boer, R.J. (2007) Editorial board member Immunology and Cell Biology (Journal)
Beltman, J.B., Mare, A.F., Lynch, J.N., Miller, M.J. & de Boer, R.J. (2007). Lymph node topology dictates T cell migration behavior. Journal of Experimental Medicine, 16, (pp. 771-780) (10 p.).
Borghans, J.A.M., Kesmir, C. & de Boer, R.J. (2007). MHC diversity in individuals and populations. In: J. Silico Immunology (pp. 177-196) (20 p.). New York: Springer (Flower, D. & Timmis, J., eds.).
de Boer, R.J. (2007) Editorial board member PLoS Computational Biology (Journal) Deputy Editor
Wucherpfennig, K.W., Allen, P.M., Celada, F., Cohen, I.R., de Boer, R.J., Perelson, A.S. & Sercarz, E.E. (2007). Polyspecificity of T cell and B cell receptor recognition. Seminars in Immunology, 19, (pp. 216-224) (9 p.).
Milutinovic, D. & de Boer, R.J. (2007). Process noise: an explanation for the fluctuations in the immune response during acute viral infection. Biophysical Journal, 92, (pp. 3358-3367) (10 p.).
Borghans, J.A.M. & de Boer, R.J. (2007). Quantification of T-cell dynamics: From telomeres to DNA labelling. Immunological Reviews, 216, (pp. 35-47) (13 p.).
Beltman, J.B., Maree, A.F.M. & de Boer, R.J. (2007). Spatial modelling of brief and long interactions between T cells and dendritic cells. Immunology and Cell Biology, 85, (pp. 306-314) (9 p.).
de Boer, R.J. (2007). Time scales of CD4+ T cell depletion in HIV infection. PLoS Computational Biology, 4, (pp. 193) (1 p.).
de Boer, R.J. (2007). Understanding the failure of CD8+ T-cell vaccination against simian/human immunodeficiency virus. Journal of Virology, 81, (pp. 2838-2848) (11 p.).
  2006 - Scholarly publications
Ganusov, V.V. & de Boer, R.J. (2006). Estimating costs and benefits of CTL escape mutations in SIV/HIV infection. PLoS Computational Biology, 2, (pp. 182-187) (6 p.).
de Boer, R.J., Ganusov, V.V., Milutinovic, D., Hodgkin, P.D. & Perelson, A.S. (2006). Estimating Lymphocyte Division and Death Rates from CFSE Data. Bulletin of Mathematical Biology, 68, (pp. 1011-1031) (21 p.).
de Boer, R.J. (2006). Estimating the role of thymic output in HIV infection. Current Opinion in HIV and AIDS, 1, (pp. 16-21) (6 p.).
Korthals Altes, H., de Boer, R.J. & Boerlijst, M. (2006). Role of avidity and breadth of the CD4 T cell response in progression to AIDS. Proceedings of the Royal Society B: Biological Sciences, 273, (pp. 1697-1704) (8 p.).
van den Dool, C. & de Boer, R.J. (2006). The effects of age, thymectomy, and HIV infection on alpha and beta TCR excis ion circles in naive T cells. Journal of Immunology, 177, (pp. 4391-4401) (11 p.).
Muller, V. & de Boer, R.J. (2006). The integration hypothesis: An evolutionary pathway to benign SIV infection. PLoS Pathogens, 2, (pp. 149-151) (3 p.).
  2005 - Scholarly publications
Luciani, F., Kesmir, C., Mishto, M., Or-Guil, M. & de Boer, R.J. (2005). A mathematical model of protein degradation by the proteasome. Biophysical Journal, 88, (pp. 2422-2432) (11 p.).
de Boer, R.J. & Perelson, A.S. (2005). Estimating division and death rates from CFSE data. Journal of Computational and Applied Mathematics, 184, (pp. 140-164) (25 p.).
Ganusov, V.V., Pilyugin, S.S., de Boer, R.J., Murali-Krishna, K., Ahmed, R. & Antia, R. (2005). Quantifying cell turnover using CFSE data. Journal of Immunological Methods, 298, (pp. 183-200) (18 p.).
  2004 - Scholarly publications
Scherer, A., Noest, A.J. & de Boer, R.J. (2004). Activation-threshold tuning in an affinity model for the T-cell repertoire. Proceedings of the Royal Society B: Biological Sciences, 271, (pp. 609-616) (8 p.).
Nobile, M., Correa, R., Borghans, J.A.M., D'Agostino, C., Schneider, P., de Boer, R.J. & Pantaleo, G. (2004). De novo T-cell generation in patients at different ages and stages of HIV-1 disease. Blood, 104, (pp. 470-477) (8 p.).
Burroughs, N.J., de Boer, R.J. & Kesmir, C. (2004). Discriminating self from nonself with short peptides from large proteosomes. Immunogenetics, 56, (pp. 311-320) (10 p.).
Hazenberg, M.D., Otto, S.A., van Rossum, G.S.A.T., Scherpbier, H.J., de Groot, R., Kuijpers, T.W., Lange, J.M., Hamann, D., de Boer, R.J., Borghans, J.A.M. & Miedema, F. (2004). Establishment of the CD4+ T-cell pool in healthy children and untreatred children infected with HIV-1. Blood, 104, (pp. 3513-3519) (7 p.).
de Boer, R.J., Borghans, J.A.M., Boven, M., Kesmir, C. & Weissing, F.J. (2004). Heterozygote advantage fails to explain the high degree of polymorphism of the MHC. Immunogenetics, 55, (pp. 725-731) (7 p.).
Borghans, J.A.M., Beltman, J.B. & de Boer, R.J. (2004). MHC polymorphism under host-pathogen coevolution. Immunogenetics, 55, (pp. 732-739) (8 p.).
  2003 - Scholarly publications
Kesmir, C. & de Boer, R.J. (2003). A spatial model of germinal center reactions: cellular adhesion based sorting of b cells results in efficient affinity maturation06. Journal of Theoretical Biology, 222, (pp. 9-22) (14 p.).
Kesmir, C., van Noort, V., de Boer, R.J. & Hogeweg, P. (2003). Bioinformatic analysis of functional differences between the immunoproteasome and the constitutive proteasome. Immunogenetics, 55, (pp. 437-449) (13 p.).
Kesmir, C. & de Boer, R.J. (2003). Clonal exhaustion as a result of immune deviation. Bulletin of Mathematical Biology, 65, (pp. 359-374) (6 p.).
Dutilh, B.E. & de Boer, R.J. (2003). Decline in excision circles is no evidence for homeostatic renewal of naive T cells. Journal of Theoretical Biology, 224, (pp. 351-358) (8 p.).
Dutilh, Bas E & de Boer, Rob J (2003). Decline in excision circles requires homeostatic renewal or homeostatic death of naive T cells. Journal of Theoretical Biology, 224 (3), (pp. 351-8) (8 p.).
Hazenberg, M.D., Otto, S.A., Hamann, D., Roos, M.T., Schuitemaker, H., de Boer, R.J. & Miedema, F. (2003). Depletion of naive CD4 T cells by CXCR4-using HIV-1 variants occurs mainly through increased T-cell death and activation. AIDS, 17, (pp. 1419-1424) (6 p.).
de Boer, R.J., Homann, D. & Perelson, A.S. (2003). Different dynamics of CD4(+) and CD8(+) T cell responses during and after acute lymphocytic choriomeningitis virus infection. Journal of Immunology, 171, (pp. 3928-3935) (8 p.).
de Boer, R.J., Mohri, H., Ho, D.D. & Perelson, A.S. (2003). Estimating average cellular turnover from 5-bromo-2'-deoxyuridine (BrdU) measurements. Proceedings of the Royal Society B: Biological Sciences, 270 (22), (pp. 849-858) (10 p.).
Carcelain, G., Saint-Mezard, P., Altes, H.K., Tubiana, R., Grenot, P., Rabian, C., de Boer, R.J., Costagliola, D., Katlama, C., Debre, P. & Autran, B. (2003). IL-2 therapy and thymic production of naive CD4 T cells in HIV-infected patients with severe CD4 lymphopenia. AIDS, 17, (pp. 841-850) (10 p.).
de Boer, R.J. (2003 2014) Editorial board member Mathematical Medicine and Biology (Journal)
Korthals Altes, H.K., Ribeiro, R.M. & de Boer, R.J. (2003). The race between initial T helper expansion and virus growth upon HIV infection influences polyclonality of the response and viral setpoint. Proceedings of the Royal Society B: Biological Sciences, 270, (pp. 1349-1358) (10 p.).
Hazenberg, M.D., Borghans, J.A.M., de Boer, R.J. & Miedema, F. (2003). Thymic output: a bad TREC record. Nature Immunology, 4, (pp. 97-99) (3 p.).
Borghans, J.A.M., Noest, A.J. & de Boer, R.J. (2003). Thymic selection does not limit the individual MHC diversity. European Journal of Immunology, 33, (pp. 3353-3358) (6 p.).
de Boer, R.J., Mohri, H., Ho, D.D. & Perelson, A.S. (2003). Turnover rates of B cells, T cells and NK cells in simian immunodeficiency virus-infected and uninfected rhesus macaques. Journal of Immunology, 170, (pp. 2479-2487) (9 p.).
  2002 - Scholarly publications
de Boer, R.J. (2002) Editorial board member Journal of Theoretical Biology (Journal)
Beltman, J.B., Borghans, J.A.M. & de Boer, R.J. (2002). Major histocompatibility complex: Polymorphism from coevolution. In U. Dieckmann, H. Metz, M. Sabelis & K. Sigmund (Eds.), Adapative Dynamics of Infectious Diseases. In Pursuit of VIrulence Management, Vol. 2 of Cambridge Studies in Adaptive Dynamics (pp. 185-197) (13 p.). Cambridge, U.K.: Cambridge University Press.
de Boer, R.J. (2002). Mathematical models of human CD4+ T-cell population kinetics. Netherlands Journal of Medicine, 60S, (pp. 17-26) (10 p.).
Borghans, J.A.M. & de Boer, R.J. (2002). Memorizing innate instructions requires a sufficiently specific adaptive immune system. International Immunology, 14, (pp. 525-532) (8 p.).
Bonhoeffer, S., Barbour, A.D. & de Boer, R.J. (2002). Procedures for reliable estimation of viral fitness from time-series data. Proceedings of the Royal Society B: Biological Sciences, 269, (pp. 1887-1893) (7 p.).
Cohen Stuart, J.W.T., Hamann, D., Borleffs, J.C.C., Roos, M., Miedema, F., Boucher, C.A.B. & de Boer, R.J. (2002). Reconstitution of naive T-cells during treatment of HIV infected adults is dependent on age. AIDS, 16, (pp. 2263-2266) (4 p.).
Boucher, C.A.B., Borleffs, J.C.C., Roos, M., Miedema, F., Hamann, D., de Boer, R.J. & Cohen Stuart, J. (2002). Reconstruction of naive T cells during antiretroviral treatment of HIV-infected adults is dependent on age. AIDS, 16, (pp. 2263-2266) (4 p.).
  2001 - Scholarly publications
Borghans, J.A.M. & de Boer, R.J. (2001). Diversity in the Immune System. In L.A. Segel & I.R. Cohen (Eds.), Design Principles for the Immune System and Other Distributed Autonomous Systems (pp. 161-183) (23 p.). Oxford, UK: Oxford University Press.
de Ronde, A., van Dooren, M., van der Hoek, L., Bouwhuis, D., de Rooij, E., van Gemen, B., de Boer, R.J. & Goudsmit, J. (2001). Establishment of new transmissible and drug-sensitive human immunodeficiency virus type 1 wild types due to transmission of nucleoside analogue-resistant virus. Journal of Virology, 75, (pp. 595-602) (8 p.).
de Boer, R.J., Oprea, M., Antia, R., Murali-Krishna, K., Ahmed, R. & Perelson, A.S. (2001). Recruitment Times, Proliferation, and Apoptosis Rates during the CD8+ T-Cell Response to Lymphocytic Choriomeningitis Virus. Journal of Virology, 75, (pp. 10663-10669) (7 p.).
Müller, V., Marée, A.F.M. & de Boer, R.J. (2001). Release of virus from lymphoid tissue affects human immunodeficiency virus type 1 and hepatitis C virus kinetics in the blood. Journal of Virology, 75, (pp. 2597-2603) (7 p.).
de Boer, R.J., Freitas, A.A. & Perelson, A.S. (2001). Resource competition determines selection of B cell repertoires. Journal of Theoretical Biology, 212, (pp. 333-343) (11 p.).
Lukashov, V.V., Huismans, R., Jebbink, M.F., Danner, S.A., de Boer, R.J. & Goudsmit, J. (2001). Selection by azt and rapid replacement in the absence of drugs of hiv type 1 resistant to multiple nucleoside analogs. AIDS Research and Human Retroviruses, 17, (pp. 807-818) (12 p.).
Müller, V., Marée, A.F.M. & de Boer, R.J. (2001). Small variations in multiple parameters account for wide variations in HIV-1 set-points: a novel modelling approach. Proceedings of the Royal Society B: Biological Sciences, 268, (pp. 235-242) (8 p.).
  2000 - Scholarly publications
Kesmir, C., Borghans, J.A.M. & de Boer, R.J. (2000). Diversity of human alpha beta T cell receptors. Science, 288, (pp. 1135a-1135a).
Marée, A.F.M., Keulen, W., Boucher, C.A.B. & de Boer, R.J. (2000). Estimating Relative Fitness in Viral Competition Experiments. Journal of Virology, 23, (pp. 11067-11072) (6 p.).
Hazenberg, M.D., Otto, S.A., Cohen Stuart, J.W.T., Verschuren, M.C., Borleffs, J.C.C., Boucher, C.A.B., Coutinho, R.A., Rinke de Wit, T.F., Tsegaye, A., van Dongen, J.M., Hamann, D., de Boer, R.J. & Miedema, F. (2000). Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nature Medicine, 6 (8), (pp. 1036-1042) (7 p.).
Rizzardi, G.P., de Boer, R.J., Hoover, S., Tambussi, G., Chapuis, A., Halkic, N., Bart, P.A., Miller, V., Staszewski, S., Notermans, D.W., Perrin, L., Fox, C.H., Lange, J.M., Lazzarin, A. & Pantaleo, G. (2000). Predicting the duration of antiviral treatment needed to suppress plasma HIV-1 RNA. Journal of Clinical Investigation, 105, (pp. 777-782) (6 p.).
Müller, V., Marée, A.F.M. & de Boer, R.J. (2000). Small variations in multiple parameters account for wide variations in HIV-1 set points: a novel modeling approach. Proceedings of the Royal Society B: Biological Sciences, 268 (1464).
Hazenberg, M.D., Cohen Stuart, J.W.T., Otto, S.A., Borleffs, J.C.C., Boucher, C.A.B., de Boer, R.J., Miedema, F. & Hamann, D. (2000). T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analaysis in patients before and during highly active antiretroviral therapy (HAART). Blood, 95, (pp. 249-255) (7 p.).
  1999 - Scholarly publications
Borghans, J.A.M., Noest, A.J. & de Boer, R.J. (1999). "How specific should immunological memory be?". Journal of Immunology, 163, (pp. 569-575) (7 p.).
Kesmir, C. & de Boer, R.J. (1999). A mathematical model on germinal center kinetics and termination. Journal of Immunology, 163, (pp. 2463-2469) (7 p.).
Borghans, J.A.M., Taams, L.S., Wauben, M.H.M. & de Boer, R.J. (1999). Competition for antigenic sites during T cell proliferation: a mathematical interpretation of in vitro data. Proceedings of the National Academy of Sciences of the United States of America, 96, (pp. 10782-10787) (6 p.).
Wolthers, K.C., Noest, A.J., Otto, S.A., Miedema, F. & de Boer, R.J. (1999). Normal telomere lengths innaive and memory CD4+ T cells in HIV type 1 infection. A mathematical interpretation. AIDS Research and Human Retroviruses, 15, (pp. 1053-1062) (10 p.).
Clark, D.R., de Boer, R.J., Wolthers, K.C. & Miedema, F. (1999). T cell dynamics in HIV-1 infection. Advances in Immunology, 73, (pp. 301-327) (27 p.).
Hazenberg, M.D., Stuart, J.W., Otto, S.A., Borleffs, J.C.C., Boucher, C.A.B., de Boer, R.J., Miedema, F. & Hamann, D. (1999). T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood, 95, (pp. 249-255) (7 p.).
  1998 - Scholarly publications
Cohen Stuart, J.W.T., Slieker, W.A.T., Rijkers, G.T., Noest, A.J., Boucher, C.A.B., de Boer, R.J., Suur, M.T., Geelen, S.P.M., Scherpbier, H.J., Hartwig, N.G., Hooijkaas, H., Roos, M., de Graeff-Meeder, E.R. & de Groot, R.P. (1998). Early recovery of CD4+ T lymphocytes in children on highly active antiretroviral therapy. Dutch study group for children with HIV infections. AIDS, 12 (16), (pp. 2155-2159) (5 p.).
Keşmir, C, De Boer, R J & Kesmir, Can (1998). How does cytopathicity affect the production of neutralizing antibody?. Scandinavian Journal of Immunology, 48 (4), (pp. 347-9) (3 p.).
de Boer, R.J., Boucher, C.A.B. & Perelson, A.S. (1998). Target Cell Availability and the Successful Suppression of HIV by Hydroxyurea and Didanosine. AIDS, 12, (pp. 1567-1570) (4 p.).
  1997 - Scholarly publications
Stilianakis, N.I., Boucher, C.A.B., de Jong, M.D., Schuurman, R. & de Boer, R.J. (1997). Clinical data sets of human immunodeficiency virus type 1 reverse transcriptase mutants explained by a mathomatical model. Journal of Virology, 71, (pp. 161-168) (8 p.).
de Jongh, M.D., de Boer, R.J., de Wolf, F., Foudraine, N.A., Boucher, C.A.B., Goutsmit, J. & Lange, J.M.A. (1997). Overshoot of HIV-1 viraemia after early discontinuation of antiretroviral treatment. AIDS, 11, (pp. F79-F83) (5 p.).
Stilianakis, N.I., Boucher, C.A.B., de Jong, T.M.C., van Leeuwen, R., Schuurman, R. & de Boer, R.J. (1997). RJ.Clinical data sets of human immunodeficiency virus type 1 reverse transcriptase-resistant mutants explained by a mathematical model. Journal of Virology, 71, (pp. 161-168) (8 p.). keypublication.
  1996 - Scholarly publications
de Jong, M.D., Veenstra, J., Stilianakis, N.I., Schuurman, R., de Boer, R.J., Lange, J.M.A. & Boucher, C.A.B. (1996). Host-parasite dynamics and outgrowth of virus containing a single K70R amino acid change in reverse transcriptase are responsible for the loss of human immunodeficiency virus type 1 RNA load suppression by zidovudine. Proceedings of the National Academy of Sciences of the United States of America, 93, (pp. 5501-5506) (6 p.). keypublication.
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Gegenereerd op 2018-06-25 16:12:51
Additional functions and activities

External Faculty Santa Fe Institute 

Editor for PLoS Computation Biology, Journal Theoretical Biology, Immunit & Cell Biology, Biology Direct.

Member of the WAR, the Scientic Advisory board of the Dutch AIDS foundation.

Gegenereerd op 2018-06-25 16:12:51
Full name
prof. dr. R.J. de Boer Contact details
Hugo R. Kruytgebouw

Padualaan 8
Room Z505
3584 CH  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 7560
Phone number (department) +31 30 253 3688
Gegenereerd op 2018-06-25 16:12:51
Last updated 14.05.2017