Prof. dr. W.J.A. (Wouter) Dhert

 
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Prof. dr. W.J.A. (Wouter) Dhert

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Highlighted publications

Visser, J., Melchels, F. P. W., Jeon, J. E., van Bussel, E. M., Kimpton, L. S., Byrne, H. M., Dhert, W. J. A., Dalton, P. D., Hutmacher, D. W., & Malda, J. (2015). Reinforcement of hydrogels using three-dimensionally printed microfibres. Nature Communications [E], 6, [6933]. https://doi.org/10.1038/ncomms7933
Niemansburg, S. L., van Delden, J. J., Dhert, W. JA., & Bredenoord, A. L. (2013). Regenerative medicine interventions for orthopedic disorders: ethical issues in the translation into patients. Regenerative Medicine, 8(1), 65-73. https://doi.org/10.2217/rme.12.112
Oner, F. C., & Dhert, W. J. A. (2011). Challenging the medico-industrial-administrative complex. Spine Journal, 11(8), 698-9. https://doi.org/10.1016/j.spinee.2011.08.010
de Windt, T. S., Vonk, L. A., Slaper-Cortenbach, I. C. M., van den Broek, M. P. H., Nizak, R., van Rijen, M. H. P., de Weger, R. A., Dhert, W. J. A., & Saris, D. B. F. (2017). Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single-Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons. Stem Cells, 35(1), 256-264. https://doi.org/10.1002/stem.2475
Delawi, D., Jacobs, W., van Susante, J. L. C., Rillardon, L., Prestamburgo, D., Specchia, N., Gay, E., Verschoor, N., Garcia-Fernandez, C., Guerado, E., Quarles van Ufford, H., Kruyt, M. C., Dhert, W. J. A., & Oner, F. C. (2016). OP-1 Compared with Iliac Crest Autograft in Instrumented Posterolateral Fusion: A Randomized, Multicenter Non-Inferiority Trial. Journal of Bone and Joint Surgery - Series A, 98(6), 441-8. https://doi.org/10.2106/JBJS.O.00209

Publications

2020

Scholarly publications

Krouwels, A., Iljas, J. D., Kragten, A. H. M., Dhert, W. J. A., Öner, F. C., Tryfonidou, M. A., & Creemers, L. B. (2020). Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration. International Journal of Molecular Sciences, 21(8). https://doi.org/10.3390/ijms21082720
Mouser, V. H. M., Levato, R., Mensinga, A., Dhert, W. J. A., Gawlitta, D., & Malda, J. (2020). Bio-ink development for three-dimensional bioprinting of hetero-cellular cartilage constructs. Connective Tissue Research, 61(2), 137-151. https://doi.org/10.1080/03008207.2018.1553960

2019

Scholarly publications

Rutgers, M., Bach, F., Vonk, L., van Rijen, M., Akrum, V., van Boxtel, A., Dhert, W., & Creemers, L. (2019). PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation. PLoS One, 14(4), [e0213483]. https://doi.org/10.1371/journal.pone.0213483
Olthof, M. G. L., Kempen, D. H. R., Liu, X., Dadsetan, M., Tryfonidou, M. A., Yaszemski, M. J., Dhert, W., & Lu, L. (2019). Effect of biomaterial electrical charge on in vivo bone formation. Tissue Engineering. Part A, 25(13/14), 1037-1052. https://doi.org/10.1089/ten.TEA.2018.0140
Olthof, M. G. L., Lu, L., Tryfonidou, M. A., Loozen, L., Pouran, B., Yaszemski, M. J., Meij, B., Dhert, W., Alblas, J., & Kempen, D. H. R. (2019). The osteoinductive effect of controlled BMP-2 release is location-dependent. Tissue Engineering. Part A, 25(3-4), 193-202. https://doi.org/10.1089/ten.TEA.2017.0427

2018

Scholarly publications

Krouwels, A., Melchels, F. P. W., van Rijen, M. H. P., Öner, F. C., Dhert, W. J. A., Tryfonidou, M. A., & Creemers, L. B. (2018). Comparing Hydrogels for Human Nucleus Pulposus Regeneration: Role of Osmolarity during Expansion. Tissue Engineering - Part C: Methods, 24(4). https://doi.org/10.1089/ten.tec.2017.0226
Olthof, M. G. L., Tryfonidou, M. A., Dadsetan, M., Dhert, W., Yaszemski, M. J., Kempen, D. H. R., & Lu, L. (2018). In Vitro and In Vivo Correlation of BMP-2 Release Profiles from Complex Delivery Vehicles. Tissue engineering. Part C, Methods, 24(7), 379-390. https://doi.org/10.1089/ten.TEC.2018.0024
Olthof, M. G. L., Kempen, D. H. R., Liu, X., Dadsetan, M., Tryfonidou, M. A., Yaszemski, M. J., Dhert, W. J. A., & Lu, L. (2018). Bone morphogenetic protein-2 release profile modulates bone formation in phosphorylated hydrogel. Journal of Tissue Engineering and Regenerative Medicine, 12(6), 1339-1351. https://doi.org/10.1002/term.2664
Krouwels, A., Melchels, F. P. W., van Rijen, M. H. P., Ten Brink, C. B. M., Dhert, W. J. A., Cumhur Öner, F., Tryfonidou, M. A., & Creemers, L. B. (2018). Focal adhesion signaling affects regeneration by human nucleus pulposus cells in collagen- but not carbohydrate-based hydrogels. Acta Biomaterialia, 66, 238-247. https://doi.org/10.1016/j.actbio.2017.11.029
Olthof, M. G. L., Tryfonidou, M., Liu, X., Pouran, B., Meij, B., Dhert, W., Yaszemski, M. J., Lu, L., Alblas, J., & Kempen, D. H. R. (2018). Phosphate functional groups improve OPF osteoconduction and BMP-2 osteoinductive efficacy. Tissue Engineering - Part A. https://doi.org/10.1089/ten.TEA.2017.0229
Mouser, V. H. M., Dautzenberg, N. M. M., Levato, R., van Rijen, M. H. P., Dhert, W. J. A., Malda, J., & Gawlitta, D. (2018). Ex vivo model unravelling cell distribution effect in hydrogels for cartilage repair. Altex, 35(1), 65-76. https://doi.org/10.14573/altex.1704171

2017

Scholarly publications

Poldervaart, M. T., Goversen, B., De Ruijter, M., Abbadessa, A., Melchels, F. P. W., Öner, F. C., Dhert, W. J. A., Vermonden, T., & Alblas, J. (2017). 3D bioprinting of methacrylated hyaluronic acid (MeHA) hydrogel with intrinsic osteogenicity. PLoS One, 12(6), 1-15. [e0177628]. https://doi.org/10.1371/journal.pone.0177628
Boot, W., Gawlitta, D., Nikkels, P. G. J., Pouran, B., van Rijen, M. H. P., Dhert, W. J. A., & Vogely, H. C. (2017). Hyaluronic Acid-Based Hydrogel Coating Does Not Affect Bone Apposition at the Implant Surface in a Rabbit Model. Clinical Orthopaedics and Related Research, 245(7), 1911-1919. https://doi.org/10.1007/s11999-017-5310-0
Croes, M., Kruyt, M. C., Loozen, L., Kragten, A. H., Yuan, H., Dhert, W. J., Öner, F. C., & Alblas, J. (2017). Local induction of inflammation affects bone formation. European Cells and Materials, 33, 211-226. https://doi.org/10.22203/eCM.v033a16
Olthof, M. G. L., Kempen, D. H. R., Herrick, J. L., Yaszemski, M. J., Dhert, W. J. A., & Lu, L. (2017). Effect of different sustained bone morphogenetic protein-2 release kinetics on bone formation in poly(propylene fumarate) scaffolds. Journal of Biomedical Materials Research - Part B Applied Biomaterials. https://doi.org/10.1002/jbm.b.33866
Güney, A., Malda, J., Dhert, W. J. A., & Grijpma, D. W. (2017). Triblock copolymers based on ε-caprolactone and trimethylene carbonate for the 3D printing of tissue engineering scaffolds. International Journal of Artificial Organs, 40(4), 133-204. https://doi.org/10.5301/ijao.5000543
de Windt, T. S., Vonk, L. A., Slaper-Cortenbach, I. C. M., van den Broek, M. P. H., Nizak, R., van Rijen, M. H. P., de Weger, R. A., Dhert, W. J. A., & Saris, D. B. F. (2017). Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single-Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons. Stem Cells, 35(1), 256-264. https://doi.org/10.1002/stem.2475
Willems, N., Mihov, G., Grinwis, G. C. M., van Dijk, M., Schumann, D., Bos, C., Strijkers, G. J., Dhert, W. J. A., Meij, B. P., Creemers, L. B., & Tryfonidou, M. A. (2017). Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 105(4), 707-714. https://doi.org/10.1002/jbm.b.33579

2016

Scholarly publications

Delawi, D., Jacobs, W., van Susante, J. L. C., Rillardon, L., Prestamburgo, D., Specchia, N., Gay, E., Verschoor, N., Garcia-Fernandez, C., Guerado, E., Quarles van Ufford, H., Kruyt, M. C., Dhert, W. J. A., & Oner, F. C. (2016). OP-1 Compared with Iliac Crest Autograft in Instrumented Posterolateral Fusion: A Randomized, Multicenter Non-Inferiority Trial. Journal of Bone and Joint Surgery - Series A, 98(6), 441-8. https://doi.org/10.2106/JBJS.O.00209
Mouser, V. H. M., Melchels, F. P. W., Visser, J., Dhert, W. J. A., Gawlitta, D., & Malda, J. (2016). Yield stress determines bioprintability of hydrogels based on gelatin-methacryloyl and gellan gum for cartilage bioprinting. Biofabrication, 8(3), [035003]. https://doi.org/10.1088/1758-5090/8/3/035003
Abbadessa, A., Mouser, V. H. M., Blokzijl, M. M., Gawlitta, D., Dhert, W. J. A., Hennink, W. E., Malda, J., & Vermonden, T. (2016). A Synthetic Thermosensitive Hydrogel for Cartilage Bioprinting and Its Biofunctionalization with Polysaccharides. Biomacromolecules, 17(6), 2137-2147. https://doi.org/10.1021/acs.biomac.6b00366
Eman, R. M., Meijer, H. A. W., Öner, F. C., Dhert, W. J. A., & Alblas, J. (2016). Establishment of an Early Vascular Network Promotes the Formation of Ectopic Bone. Tissue Engineering. Part A, 22(3-4), 253-62. https://doi.org/10.1089/ten.TEA.2015.0227
Croes, M., Öner, F. C., van Neerven, D., Sabir, E., Kruyt, M. C., Blokhuis, T. J., Dhert, W. J. A., & Alblas, J. (2016). Proinflammatory T cells and IL-17 stimulate osteoblast differentiation. Bone, 84, 262-270. https://doi.org/10.1016/j.bone.2016.01.010

2015

Scholarly publications

Niemansburg, S. L., Tempels, T. H., Dhert, W. J. A., van Delden, J. J. M., & Bredenoord, A. L. (2015). Societal impacts of regenerative medicine: reflections on the views of orthopedic professionals. Regenerative Medicine, 10(1), 17-24. https://doi.org/10.2217/rme.14.69
Wegman, F., Poldervaart, M. T., van der Helm, Y. J., Oner, F. C., Dhert, W. J., & Alblas, J. (2015). Combination of bone morphogenetic protein-2 plasmid DNA with chemokine CXCL12 creates an additive effect on bone formation onset and volume. European Cells and Materials, 30, 1-10; discussion 10-1.
Poldervaart, M. T., van der Stok, J., de Haas, M., ‘T Hart, M. C., Öner, F. C., Dhert, W. J. A., Weinans, H., & Alblas, J. (2015). Growth factor-induced osteogenesis in a novel radiolucent bone chamber. European Cells & Materials [E], 29, 35-41. https://doi.org/10.22203/eCM.v029a03
Niemansburg, S. L., Habets, M. G. J. L., Dhert, W. J. A., van Delden, J. J. M., & Bredenoord, A. L. (2015). Participant selection for preventive Regenerative Medicine trials: ethical challenges of selecting individuals at risk. Journal of Medical Ethics, 41(11), 914-6. https://doi.org/10.1136/medethics-2014-102625
Boot, W., Moojen, D. J. F., Visser, E., Lehr, A. M., De Windt, T. S., Van Hellemondt, G., Geurts, J., Tulp, N. J. A., Schreurs, B. W., Burger, B. J., Dhert, W. J. A., Gawlitta, D., & Vogely, H. C. (2015). Missed low-grade infection in suspected aseptic loosening has no consequences for the survival of total hip arthroplasty. Acta Orthopaedica, 86(6), 678-83. https://doi.org/10.3109/17453674.2015.1086942
Visser, J., Melchels, F. P. W., Mancini, I. A. D., Brommer, H., Jeon, J. E., Dalton, P. D., Dhert, W. J. A., Saris, D. B. F., Hutmacher, D. W., van Weeren, P. R., & Malda, J. (2015). Reinforced gelatin hydrogels for cartilage repair; from in vitro testing to implantation in the equine stifle join. In Reinforced gelatin hydrogels for cartilage repair; from in vitro testing to implantation in the equine stifle join
Visser, J., Melchers, F., Mancini, I. A. D., Brommer, H., Jeon, J. E., Dalton, P., Dhert, W. J. A., Saris, D. B. F., Hutmacher, D. W., van Weeren, P. R., & Malda, J. (2015). Reinforced gelatin hydrogels for cartilage repair: from in vitro testing to implantation in the equine knee joint. In Reinforced gelatin hydrogels for cartilage repair: from in vitro testing to implantation in the equine knee joint
Visser, J., Gawlitta, D., Benders, K. E. M., Toma, S. M. H., Pouran, B., van Weeren, P. R., Dhert, W. J. A., & Malda, J. (2015). Endochondral bone formation in gelatin methacrylamide hydrogel with embedded cartilage-derived matrix particles. Biomaterials, 37, 174-182. https://doi.org/10.1016/j.biomaterials.2014.10.020
Visser, J., Levett, P. A., te Moller, N. C. R., Besems, J., Boere, K. W. M., van Rijen, M. H. P., de Grauw, J. C., Dhert, W. J. A., van Weeren, P. R., & Malda, J. (2015). Crosslinkable Hydrogels Derived from Cartilage, Meniscus, and Tendon Tissue. Tissue Engineering. Part A, 21(7-8), 1195-1206. https://doi.org/10.1089/ten.tea.2014.0362
de Windt, T. S., Saris, D. B. F., Slaper-Cortenbach, I. C. M., van Rijen, M. H. P., Gawlitta, D., Creemers, L. B., de Weger, R. A., Dhert, W. J. A., & Vonk, L. A. (2015). Direct Cell-Cell Contact with Chondrocytes Is a Key Mechanism in Multipotent Mesenchymal Stromal Cell-Mediated Chondrogenesis. Tissue Engineering. Part A, 21(19-20), 2536-2547. https://doi.org/10.1089/ten.TEA.2014.0673
Croes, M., Oner, F. C., Kruyt, M. C., Blokhuis, T. J., Bastian, O., Dhert, W. J. A., & Alblas, J. (2015). Proinflammatory Mediators Enhance the Osteogenesis of Human Mesenchymal Stem Cells after Lineage Commitment. PLoS One, 10(7), [e0132781]. https://doi.org/10.1371/journal.pone.0132781
Willems, N., Yang, H-Y., Langelaan, M. L. P., Tellegen, A. R., Grinwis, G. C. M., Kranenburg, H-J. C., Riemers, F. M., Plomp, S. G. M., Craenmehr, E. G. M., Dhert, W. J. A., Papen-Botterhuis, N. E., Meij, B. P., Creemers, L. B., & Tryfonidou, M. (2015). Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model. Arthritis Research & Therapy, 17(1), 214. https://doi.org/10.1186/s13075-015-0727-x
Yang, H-Y., van Ee, R. J., Timmer, K., Craenmehr, E. G. M., Huang, J. H., Öner, F. C., Dhert, W. J. A., Kragten, A. H. M., Willems, N., Grinwis, G. C. M., Tryfonidou, M. A., Papen-Botterhuis, N. E., & Creemers, L. B. (2015). A novel injectable thermoresponsive and cytocompatible gel of poly(N-isopropylacrylamide) with layered double hydroxides facilitates siRNA delivery into chondrocytes in 3D culture. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2015.05.018
Janssen, S. J., Bredenoord, A. L., Dhert, W., de Kleuver, M., Oner, F. C., & Verlaan, J-J. (2015). Potential Conflicts of Interest of Editorial Board Members from Five Leading Spine Journals. PLoS One, 10(6), [e0127362]. https://doi.org/10.1371/journal.pone.0127362
Willems, N., Bach, F. C., Plomp, S. G. M., van Rijen, M. H., Wolfswinkel, J., Grinwis, G. C., Bos, C., Strijkers, G. J., Dhert, W. J., Meij, B. P., Creemers, L. B., & Tryfonidou, M. A. (2015). Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration. Arthritis Research & Therapy, 17, 1-14. [137]. https://doi.org/10.1186/s13075-015-0625-2
Niemansburg, S. L., van Delden, J. J. M., Dhert, W. J. A., & Bredenoord, A. L. (2015). Reconsidering the ethics of sham interventions in an era of emerging technologies. Surgery, 157(4), 801-10. https://doi.org/10.1016/j.surg.2014.12.001
Loozen, L. D., van der Helm, Y. J. M., Öner, F. C., Dhert, W. J. A., Kruyt, M. C., & Alblas, J. (2015). Bone morphogenetic protein-2 nonviral gene therapy in a goat iliac crest model for bone formation. Tissue Engineering. Part A, 21(9-10), 1672-9. https://doi.org/10.1089/ten.TEA.2014.0593
Krouwels, A., Popov-Celeketic, J., Plomp, S. G. M., Dhert, W. J. A., Öner, F. C., Bank, R. A., & Creemers, L. B. (2015). No effects of Hyperosmolar Culture medium on Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells despite Upregulation Extracellular Matrix Genes. Spine. https://doi.org/10.1097/BRS.0000000000000920
Visser, J., Melchels, F. P. W., Jeon, J. E., van Bussel, E. M., Kimpton, L. S., Byrne, H. M., Dhert, W. J. A., Dalton, P. D., Hutmacher, D. W., & Malda, J. (2015). Reinforcement of hydrogels using three-dimensionally printed microfibres. Nature Communications [E], 6, [6933]. https://doi.org/10.1038/ncomms7933
Schuurman, W., Klein, T. J., Dhert, W. J. A., van Weeren, P. R., Hutmacher, D. W., & Malda, J. (2015). Cartilage regeneration using zonal chondrocyte subpopulations: a promising approach or an overcomplicated strategy? Journal of Tissue Engineering and Regenerative Medicine, 9(6), 669-678. https://doi.org/10.1002/term.1638
Rutgers, M., Creemers, L. B., Yang, K. G. A., Raijmakers, N. J. H., Dhert, W. J. A., & Saris, D. B. F. (2015). Osteoarthritis treatment using autologous conditioned serum after placebo. Acta Orthopaedica, 86(1), 114–118. https://doi.org/10.3109/17453674.2014.950467
de Windt, T. S., Vonk, L. A., Buskermolen, J. K., Visser, J., Karperien, M., Bleys, R. L. A. W., Dhert, W. J. A., & Saris, D. B. F. (2015). Arthroscopic airbrush assisted cell implantation for cartilage repair in the knee: a controlled laboratory and human cadaveric study. Osteoarthritis and Cartilage, 23(1), 143-150. https://doi.org/10.1016/j.joca.2014.09.016
Gawlitta, D., Benders, K. E. M., Visser, J., van der Sar, A. S., Kempen, D. H. R., Theyse, L. F. H., Malda, J., & Dhert, W. J. A. (2015). Decellularized Cartilage-Derived Matrix as Substrate for Endochondral Bone Regeneration. Tissue Engineering. Part A, 21(3-4), 694-703. https://doi.org/10.1089/ten.TEA.2014.0117

Other output

Boot, W., Vogely, H., Nikkels, P., Dhert, W., & Gawlitta, D. (2015). Local prophylaxis of implant-related infections using a hydrogel as carrier. http://www.mendeley.com/research/local-prophylaxis-implantrelated-infections-using-hydrogel-carrier

2014

Scholarly publications

Krouwels, A., Iljas, L., Plomp, S., Dhert, W., Oner, C., & Creemers, L. B. (2014). BMPs Enhance in Vitro Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells. Global Spine Journal, 4(1_suppl), s-0034-1376562-s-0034-1376562. https://doi.org/10.1055/s-0034-1376562
Krouwels, A., Popov, J., Plomp, S., Dhert, W., Oner, C., Bank, R., & Creemers, L. (2014). In Vitro Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells in Hyperosmotic Culture Medium. Global Spine Journal, 4(1_suppl), s-0034-1376656-s-0034-1376656. https://doi.org/10.1055/s-0034-1376656
Benders, K. E. M., Boot, W., van Weeren, R., Gawlitta, D., Bergman, E., Saris, D. B. F., Dhert, W., & Malda, J. (2014). Multipotent stromal cells outperform chondrocytes on cartilage-derived matrix scaffolds. Cartilage, 5(4), 221-230. https://doi.org/10.1177/1947603514535245
Melchels, F. P. W., Dhert, W. J. A., Hutmacher, D. W., & Malda, J. (2014). Development and characterisation of a new bioink for additive tissue manufacturing. Journal of Materials Chemistry A, 2(16), 2282-2289. https://doi.org/10.1039/c3tb21280g
Wegman, F., Geuze, R. E., van der Helm, Y. J., Cumhur Öner, F., Dhert, W. J. A., & Alblas, J. (2014). Gene delivery of bone morphogenetic protein-2 plasmid DNA promotes bone formation in a large animal model. Journal of Tissue Engineering and Regenerative Medicine, 8(10), 763-70. https://doi.org/10.1002/term.1571
Eman, R. M., Oner, F. C., Kruyt, M. C., Dhert, W. J. A., & Alblas, J. (2014). Stromal cell-derived factor-1 stimulates cell recruitment, vascularization and osteogenic differentiation. Tissue Engineering. Part A, 20(3-4), 466-473. https://doi.org/10.1089/ten.TEA.2012.0653
Bekkers, J. E. J., Saris, D. B. F., Tsuchida, A. I., van Rijen, M. H. P., Dhert, W. J. A., & Creemers, L. B. (2014). Chondrogenic potential of articular chondrocytes depends on their original location. Tissue Engineering. Part A, 20(3-4), 663-71. https://doi.org/10.1089/ten.TEA.2012.0673
Niemansburg, S. L., van Delden, J. J. M., Oner, F. C., Dhert, W. J. A., & Bredenoord, A. L. (2014). Ethical implications of regenerative medicine in orthopedics: an empirical study with surgeons and scientists in the field. The Spine Journal, 14(6), 1029-35. https://doi.org/10.1016/j.spinee.2013.10.016
Vonk, L. A., Kragten, A. H. M., Dhert, W. J. A., Saris, D. B. F., & Creemers, L. B. (2014). Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes. Osteoarthritis and Cartilage, 22(1), 145-53. https://doi.org/10.1016/j.joca.2013.11.006
Yang, H., Vonk, L. A., Licht, R., van Boxtel, A. M. G., Bekkers, J. E. J., Kragten, A. H. M., Hein, S., Varghese, O. P., Howard, K. A., Öner, F. C., Dhert, W. J. A., & Creemers, L. B. (2014). Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells. European Journal of Pharmaceutical Sciences, 53, 35-44. https://doi.org/10.1016/j.ejps.2013.12.006
Kock, L. M., Malda, J., Dhert, W. J. A., Ito, K., & Gawlitta, D. (2014). Flow-perfusion interferes with chondrogenic and hypertrophic matrix production by mesenchymal stem cells. Journal of Biomechanics, 47(9), 2122-2129. https://doi.org/10.1016/j.jbiomech.2013.11.006
Poldervaart, M. T., Gremmels, H., van Deventer, K., Fledderus, J. O., Oner, F. C., Verhaar, M. C., Dhert, W. J. A., & Alblas, J. (2014). Prolonged presence of VEGF promotes vascularization in 3D bioprinted scaffolds with defined architecture. Journal of Controlled Release, 184, 58-66. https://doi.org/10.1016/j.jconrel.2014.04.007
Eman, R. M., Hoorntje, E. T., Oner, F. C., Kruyt, M. C., Dhert, W. J. A., & Alblas, J. (2014). CXCL12/Stromal-Cell-Derived Factor-1 Effectively Replaces Endothelial Progenitor Cells to Induce Vascularized Ectopic Bone. Stem Cells and Development, 23(24), 2950-8. https://doi.org/10.1089/scd.2013.0560
Vonk, L. A., de Windt, T. S., Kragten, A. H. M., Beekhuizen, M., Mastbergen, S. C., Dhert, W. J. A., Lafeber, F. P. J. G., Creemers, L. B., & Saris, D. B. F. (2014). Enhanced cell-induced articular cartilage regeneration by chondrons; the influence of joint damage and harvest site. Osteoarthritis and Cartilage, 22(11), 1910-7. https://doi.org/10.1016/j.joca.2014.08.005
Yang, H-Y., van Dijk, M., Licht, R., Beekhuizen, M., van Rijen, M., Janstål, M. K., Oner, F. C., Dhert, W. J. A., Schumann, D., & Creemers, L. B. (2014). Applicability of a Newly Developed Bioassay for Determining Bioactivity of Anti-Inflammatory Compounds in Release Studies - Celecoxib and Triamcinolone Acetonide Released from Novel PLGA-Based Microspheres. Pharmaceutical Research, 2015(32), 680-690. https://doi.org/10.1007/s11095-014-1495-z
Tsuchida, A. I., Beekhuizen, M., T Hart, M. C., Radstake, T., Dhert, W., Saris, D., van Osch, G., & Creemers, L. B. (2014). Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes. Arthritis Research & Therapy, 16(5). https://doi.org/10.1186/s13075-014-0441-0
Prins, H. J., Braat, A. K., Gawlitta, D., Dhert, W. J. A., Egan, D. A., Tijssen-Slump, E., Yuan, H., Coffer, P. J., Rozemuller, H., & Martens, A. C. M. (2014). In vitro induction of alkaline phosphatase levels predicts in vivo bone forming capacity of human bone marrow stromal cells. Stem Cell Research, 12, 428-440. https://doi.org/10.1016/j.scr.2013.12.001

2013

Scholarly publications

Verlaan, J-J., Dhert, W. J. A., & Oner, F. C. (2013). Intervertebral disc viability after burst fractures of the thoracic and lumbar spine treated with pedicle screw fixation and direct end-plate restoration. The Spine Journal, 13(3), 217-21. https://doi.org/10.1016/j.spinee.2012.02.032
Niemansburg, S. L., van Delden, J. J., Dhert, W. JA., & Bredenoord, A. L. (2013). Regenerative medicine interventions for orthopedic disorders: ethical issues in the translation into patients. Regenerative Medicine, 8(1), 65-73. https://doi.org/10.2217/rme.12.112
Mentink, A., Hulsman, M., Groen, N., Licht, R., Dechering, K. J., van der Stok, J., Alves, H. A., Dhert, W. JA., van Someren, E. P., Reinders, M. J. T., van Blitterswijk, C. A., & de Boer, J. (2013). Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1. Biomaterials, 34(19), 4592-4601. https://doi.org/10.1016/j.biomaterials.2013.03.001
Verlaan, J-J., Somers, I., Dhert, W. J. A., & Oner, F. C. (2013). Clinical and radiological results 6 years after treatment of traumatic thoracolumbar burst fractures with pedicle screw instrumentation and balloon assisted end plate reduction. The Spine Journal. https://doi.org/10.1016/j.spinee.2013.11.044
Wegman, F., Oner, F. C., Dhert, W. J. A., & Alblas, J. (2013). Non-viral gene therapy for bone tissue engineering. Biotechnology & Genetic Engineering Reviews, 29, 206-20. https://doi.org/10.1080/02648725.2013.801227
Bekkers, J. E. J., Bartels, L. W., Benink, R. J., Tsuchida, A. I., Vincken, K. L., Dhert, W. J. A., Creemers, L. B., & Saris, D. B. F. (2013). Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) can be effectively applied for longitudinal cohort evaluation of articular cartilage regeneration. Osteoarthritis and Cartilage, 21(7), 943-949. https://doi.org/10.1016/j.joca.2013.03.017
Schuurman, W., Harimulyo, E. B., Gawlitta, D., Woodfield, T. B. F., Dhert, W. J. A., van Weeren, P. R., & Malda, J. (2013). Three-dimensional assembly of tissue-engineered cartilage constructs results in cartilaginous tissue formation without retainment of zonal characteristics. Journal of Tissue Engineering and Regenerative Medicine, 10(4), 315-324. https://doi.org/10.1002/term.1726
Halma, J. J., Vogely, H. C., Dhert, W. J., Van Gaalen, S. M., & de Gast, A. (2013). Do monoblock cups improve survivorship, decrease wear, or reduce osteolysis in uncemented total hip arthroplasty? Clinical Orthopaedics and Related Research, 471(11), 3572-80. https://doi.org/10.1007/s11999-013-3144-y

2012

Scholarly publications

Seyednejad, H., Ji, W., Yang, F., Van Nostrum, C. F., Vermonden, T., Van Den Beucken, J. J. J. P., Dhert, W. J. A., Hennink, W. E., & Jansen, J. A. (2012). Coaxially electrospun scaffolds based on hydroxyl-functionalized poly(ε-caprolactone) and loaded with VEGF for tissue engineering applications. Biomacromolecules, 13(11), 3650-3660. https://doi.org/10.1021/bm301101r
Seyednejad, H., Gawlitta, D., Kuiper, R. V., de Bruin, A., van Nostrum, C. F., Vermonden, T., Dhert, W. J. A., & Hennink, W. E. (2012). In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly(ε-caprolactone). Biomaterials, 33(17), 4309-18. https://doi.org/10.1016/j.biomaterials.2012.03.002
Geuze, R. E., Theyse, L. F. H., Kempen, D. H. R., Hazewinkel, H. A. W., Kraak, H. Y. A., Oner, F. C., Dhert, W. J. A., & Alblas, J. (2012). A differential effect of bone morphogenetic protein-2 and vascular endothelial growth factor release timing on osteogenesis at ectopic and orthotopic sites in a large-animal model. Tissue Engineering - Part A., 18(19-20), 2052-62. https://doi.org/10.1089/ten.TEA.2011.0560
Smolders, L. A., Kingma, I., Bergknut, N., van der Veen, A. J., Dhert, W. J. A., Hazewinkel, H. A. W., van Dieen, J. H., & Meij, B. P. (2012). Biomechanical assessment of the effects of decompressive surgery in non-chondrodystrophic and chondrodystrophic canine multisegmented lumbar spines. European Spine Journal, 21(9), 1692-1699. http://www.ncbi.nlm.nih.gov/pubmed/22492242

2011

Scholarly publications

Fujishiro, T., Moojen, D. J. F., Kobayashi, N., Dhert, W. J. A., & Bauer, T. W. (2011). Perivascular and diffuse lymphocytic inflammation are not specific for failed metal-on-metal hip implants. Clinical Orthopaedics and Related Research, 469(4), 1127-33. https://doi.org/10.1007/s11999-010-1649-1
Verlaan, J. J., Westerveld, L. A., van Keulen, J. W., Bleys, R. L. A. W., Dhert, W. J., van Herwaarden, J. A., Moll, F. L., & Oner, F. C. (2011). Quantitative analysis of the anterolateral ossification mass in diffuse idiopathic skeletal hyperostosis of the thoracic spine. European Spine Journal, 20(9), 1474-9. https://doi.org/10.1007/s00586-011-1719-4
Beekhuizen, M., Bastiaansen-Jenniskens, Y. M., Koevoet, W., Saris, D. B. F., Dhert, W. J. A., Creemers, L. B., & van Osch, G. J. V. M. (2011). Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: establishment and characterization of a long-term cartilage-synovium coculture. Arthritis and Rheumatism, 63(7), 1918-27. https://doi.org/10.1002/art.30364
Fedorovich, N. E., Wijnberg, H. M., Dhert, W. J. A., & Alblas, J. (2011). Distinct tissue formation by heterogeneous printing of osteo- and endothelial progenitor cells. Tissue Engineering - Part A., 17(15-16), 2113-21. https://doi.org/10.1089/ten.TEA.2011.0019
Oner, F. C., & Dhert, W. J. A. (2011). Challenging the medico-industrial-administrative complex. Spine Journal, 11(8), 698-9. https://doi.org/10.1016/j.spinee.2011.08.010
Verlaan, J-J., Boswijk, P. F. E., de Ru, J. A., Dhert, W. J. A., & Oner, F. C. (2011). Diffuse idiopathic skeletal hyperostosis of the cervical spine: an underestimated cause of dysphagia and airway obstruction. Spine Journal, 11(11), 1058-67. https://doi.org/10.1016/j.spinee.2011.09.014

2010

Scholarly publications

Delawi, D., Dhert, W. J. A., Rillardon, L., Gay, E., Prestamburgo, D., Garcia-Fernandez, C., Guerado, E., Specchia, N., Van Susante, J. L. C., Verschoor, N., van Ufford, H. M. E. Q., & Oner, F. C. (2010). A prospective, randomized, controlled, multicenter study of osteogenic protein-1 in instrumented posterolateral fusions: report on safety and feasibility. Spine, 35(12), 1185-91. https://doi.org/10.1097/BRS.0b013e3181d3cf28
Kempen, D. H. R., Lu, L., Hefferan, T. E., Creemers, L. B., Heijink, A., Maran, A., Dhert, W. J. A., & Yaszemski, M. J. (2010). Enhanced bone morphogenetic protein-2-induced ectopic and orthotopic bone formation by intermittent parathyroid hormone (1-34) administration. Tissue Engineering - Part A., 16(12), 3769-77. https://doi.org/10.1089/ten.TEA.2010.0173
Moojen, D. J. F., van Hellemondt, G., Vogely, H. C., Burger, B. J., Walenkamp, G. H. I. M., Tulp, N. J. A., Schreurs, B. W., de Meulemeester, F. R. A. J., Schot, C. S., van de Pol, I., Fujishiro, T., Schouls, L. M., Bauer, T. W., & Dhert, W. J. A. (2010). Incidence of low-grade infection in aseptic loosening of total hip arthroplasty. Acta Orthopaedica, 81(6), 667-73. https://doi.org/10.3109/17453674.2010.525201

2008

Scholarly publications

Malda, J., Rouwkema, J., Leeuwenburgh, S. C. G., Dhert, W. J. A., & Kirkpatrick, C. J. (2008). Crossing frontiers in biomaterials and regenerative medicine. 8th World Biomaterials Congress, 28 May - 1 June, Amsterdam, The Netherlands. Regenerative Medicine, 3(5), 765-8. https://doi.org/10.2217/17460751.3.5.765
Leeuwenburgh, S. C. G., Jansen, J. A., Malda, J., Dhert, W. A., Rouwkema, J., van Blitterswijk, C. A., Kirkpatrick, C. J., & Williams, D. F. (2008). Trends in biomaterials research: An analysis of the scientific programme of the World Biomaterials Congress 2008. Biomaterials, 29(21), 3047-52. https://doi.org/10.1016/j.biomaterials.2008.04.032
Fedorovich, N., Van Geemen, D., Oudshoorn, M., Hennink, W., Alblas, J., & Dhert, W. (2008). Applicability of photopolymerizable hydrogels for bone tissue printing. In 8th World Biomaterials Congress 2008 (Vol. 4)
Vermonden, T., Fedorovich, N. E., Van Geemen, D., Alblas, J., Van Nostrum, C. F., Dhert, W. J. A., & Hennink, W. E. (2008). Degradation behavior and cytocompatibility of photopolymerized thermosensitive hydrogels. In 8th World Biomaterials Congress 2008 (Vol. 4)

2002

Scholarly publications

Öner, F. C., van Gils, A., Faber, J. A. J., Dhert, W. J. A., & Verbout, A. J. (2002). Some complications of common treatment schemes of thoracolumbar spine fractures can be predicted with magnetic resonance imaging: prospective study of 53 patients with 71 fractures. Spine, 27, 629-636.