Publications
2020
Scholarly publications
Krouwels, A., Iljas, J. D., Kragten, A. H. M.
, Dhert, W. J. A., Öner, F. C.
, Tryfonidou, M. A., & Creemers, L. B. (2020).
Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration.
International Journal of Molecular Sciences,
21(8).
https://doi.org/10.3390/ijms21082720Mouser, V. H. M., Levato, R., Mensinga, A.
, Dhert, W. J. A., Gawlitta, D.
, & Malda, J. (2020).
Bio-ink development for three-dimensional bioprinting of hetero-cellular cartilage constructs.
Connective Tissue Research,
61(2), 137-151.
https://doi.org/10.1080/03008207.2018.15539602019
Scholarly publications
Rutgers, M.
, Bach, F., Vonk, L., van Rijen, M., Akrum, V., van Boxtel, A.
, Dhert, W., & Creemers, L. (2019).
PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation.
PLoS One,
14(4), [e0213483].
https://doi.org/10.1371/journal.pone.0213483Olthof, M. G. L., Kempen, D. H. R., Liu, X., Dadsetan, M.
, Tryfonidou, M. A., Yaszemski, M. J.
, Dhert, W., & Lu, L. (2019).
Effect of biomaterial electrical charge on in vivo bone formation.
Tissue Engineering. Part A,
25(13/14), 1037-1052.
https://doi.org/10.1089/ten.TEA.2018.0140 Olthof, M. G. L., Lu, L.
, Tryfonidou, M. A., Loozen, L., Pouran, B., Yaszemski, M. J.
, Meij, B., Dhert, W., Alblas, J., & Kempen, D. H. R. (2019).
The osteoinductive effect of controlled BMP-2 release is location-dependent.
Tissue Engineering. Part A,
25(3-4), 193-202.
https://doi.org/10.1089/ten.TEA.2017.0427 2018
Scholarly publications
Krouwels, A.
, Melchels, F. P. W., van Rijen, M. H. P., Öner, F. C.
, Dhert, W. J. A., Tryfonidou, M. A., & Creemers, L. B. (2018).
Comparing Hydrogels for Human Nucleus Pulposus Regeneration: Role of Osmolarity during Expansion.
Tissue Engineering - Part C: Methods,
24(4).
https://doi.org/10.1089/ten.tec.2017.0226Olthof, M. G. L., Tryfonidou, M. A., Dadsetan, M.
, Dhert, W., Yaszemski, M. J., Kempen, D. H. R., & Lu, L. (2018).
In Vitro and In Vivo Correlation of BMP-2 Release Profiles from Complex Delivery Vehicles.
Tissue engineering. Part C, Methods,
24(7), 379-390.
https://doi.org/10.1089/ten.TEC.2018.0024 Olthof, M. G. L., Kempen, D. H. R., Liu, X., Dadsetan, M.
, Tryfonidou, M. A., Yaszemski, M. J.
, Dhert, W. J. A., & Lu, L. (2018).
Bone morphogenetic protein-2 release profile modulates bone formation in phosphorylated hydrogel.
Journal of Tissue Engineering and Regenerative Medicine,
12(6), 1339-1351.
https://doi.org/10.1002/term.2664 Krouwels, A.
, Melchels, F. P. W., van Rijen, M. H. P., Ten Brink, C. B. M.
, Dhert, W. J. A., Cumhur Öner, F.
, Tryfonidou, M. A., & Creemers, L. B. (2018).
Focal adhesion signaling affects regeneration by human nucleus pulposus cells in collagen- but not carbohydrate-based hydrogels.
Acta Biomaterialia,
66, 238-247.
https://doi.org/10.1016/j.actbio.2017.11.029Olthof, M. G. L., Tryfonidou, M., Liu, X., Pouran, B.
, Meij, B., Dhert, W., Yaszemski, M. J., Lu, L., Alblas, J., & Kempen, D. H. R. (2018).
Phosphate functional groups improve OPF osteoconduction and BMP-2 osteoinductive efficacy.
Tissue Engineering - Part A. https://doi.org/10.1089/ten.TEA.2017.0229 Mouser, V. H. M., Dautzenberg, N. M. M., Levato, R., van Rijen, M. H. P.
, Dhert, W. J. A., Malda, J., & Gawlitta, D. (2018).
Ex vivo model unravelling cell distribution effect in hydrogels for cartilage repair.
Altex,
35(1), 65-76.
https://doi.org/10.14573/altex.17041712017
Scholarly publications
Poldervaart, M. T., Goversen, B., De Ruijter, M.
, Abbadessa, A., Melchels, F. P. W., Öner, F. C.
, Dhert, W. J. A., Vermonden, T., & Alblas, J. (2017).
3D bioprinting of methacrylated hyaluronic acid (MeHA) hydrogel with intrinsic osteogenicity.
PLoS One,
12(6), 1-15. [e0177628].
https://doi.org/10.1371/journal.pone.0177628Boot, W., Gawlitta, D., Nikkels, P. G. J., Pouran, B., van Rijen, M. H. P.
, Dhert, W. J. A., & Vogely, H. C. (2017).
Hyaluronic Acid-Based Hydrogel Coating Does Not Affect Bone Apposition at the Implant Surface in a Rabbit Model.
Clinical Orthopaedics and Related Research,
245(7), 1911-1919.
https://doi.org/10.1007/s11999-017-5310-0 Croes, M., Kruyt, M. C., Loozen, L., Kragten, A. H., Yuan, H.
, Dhert, W. J., Öner, F. C., & Alblas, J. (2017).
Local induction of inflammation affects bone formation.
European Cells and Materials,
33, 211-226.
https://doi.org/10.22203/eCM.v033a16Olthof, M. G. L., Kempen, D. H. R., Herrick, J. L., Yaszemski, M. J.
, Dhert, W. J. A., & Lu, L. (2017).
Effect of different sustained bone morphogenetic protein-2 release kinetics on bone formation in poly(propylene fumarate) scaffolds.
Journal of Biomedical Materials Research - Part B Applied Biomaterials.
https://doi.org/10.1002/jbm.b.33866 Güney, A.
, Malda, J., Dhert, W. J. A., & Grijpma, D. W. (2017).
Triblock copolymers based on ε-caprolactone and trimethylene carbonate for the 3D printing of tissue engineering scaffolds.
International Journal of Artificial Organs,
40(4), 133-204.
https://doi.org/10.5301/ijao.5000543de Windt, T. S.
, Vonk, L. A., Slaper-Cortenbach, I. C. M., van den Broek, M. P. H., Nizak, R., van Rijen, M. H. P., de Weger, R. A.
, Dhert, W. J. A., & Saris, D. B. F. (2017).
Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single-Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons.
Stem Cells,
35(1), 256-264.
https://doi.org/10.1002/stem.2475Willems, N., Mihov, G.
, Grinwis, G. C. M., van Dijk, M., Schumann, D., Bos, C., Strijkers, G. J.
, Dhert, W. J. A., Meij, B. P., Creemers, L. B.
, & Tryfonidou, M. A. (2017).
Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration.
Journal of Biomedical Materials Research. Part B, Applied Biomaterials,
105(4), 707-714.
https://doi.org/10.1002/jbm.b.33579 2016
Scholarly publications
Delawi, D., Jacobs, W., van Susante, J. L. C., Rillardon, L., Prestamburgo, D., Specchia, N., Gay, E., Verschoor, N., Garcia-Fernandez, C., Guerado, E., Quarles van Ufford, H., Kruyt, M. C.
, Dhert, W. J. A., & Oner, F. C. (2016).
OP-1 Compared with Iliac Crest Autograft in Instrumented Posterolateral Fusion: A Randomized, Multicenter Non-Inferiority Trial.
Journal of Bone and Joint Surgery - Series A,
98(6), 441-8.
https://doi.org/10.2106/JBJS.O.00209Mouser, V. H. M.
, Melchels, F. P. W., Visser, J., Dhert, W. J. A., Gawlitta, D.
, & Malda, J. (2016).
Yield stress determines bioprintability of hydrogels based on gelatin-methacryloyl and gellan gum for cartilage bioprinting.
Biofabrication,
8(3), [035003].
https://doi.org/10.1088/1758-5090/8/3/035003Abbadessa, A., Mouser, V. H. M.
, Blokzijl, M. M., Gawlitta, D.
, Dhert, W. J. A., Hennink, W. E., Malda, J., & Vermonden, T. (2016).
A Synthetic Thermosensitive Hydrogel for Cartilage Bioprinting and Its Biofunctionalization with Polysaccharides.
Biomacromolecules,
17(6), 2137-2147.
https://doi.org/10.1021/acs.biomac.6b00366 Eman, R. M., Meijer, H. A. W., Öner, F. C.
, Dhert, W. J. A., & Alblas, J. (2016).
Establishment of an Early Vascular Network Promotes the Formation of Ectopic Bone.
Tissue Engineering. Part A,
22(3-4), 253-62.
https://doi.org/10.1089/ten.TEA.2015.0227Croes, M., Öner, F. C., van Neerven, D., Sabir, E., Kruyt, M. C., Blokhuis, T. J.
, Dhert, W. J. A., & Alblas, J. (2016).
Proinflammatory T cells and IL-17 stimulate osteoblast differentiation.
Bone,
84, 262-270.
https://doi.org/10.1016/j.bone.2016.01.0102015
Scholarly publications
Niemansburg, S. L., Tempels, T. H.
, Dhert, W. J. A., van Delden, J. J. M., & Bredenoord, A. L. (2015).
Societal impacts of regenerative medicine: reflections on the views of orthopedic professionals.
Regenerative Medicine,
10(1), 17-24.
https://doi.org/10.2217/rme.14.69Wegman, F., Poldervaart, M. T., van der Helm, Y. J., Oner, F. C., Dhert, W. J., & Alblas, J. (2015). Combination of bone morphogenetic protein-2 plasmid DNA with chemokine CXCL12 creates an additive effect on bone formation onset and volume. European Cells and Materials, 30, 1-10; discussion 10-1.
Poldervaart, M. T., van der Stok, J.
, de Haas, M., ‘T Hart, M. C., Öner, F. C.
, Dhert, W. J. A., Weinans, H., & Alblas, J. (2015).
Growth factor-induced osteogenesis in a novel radiolucent bone chamber.
European Cells & Materials [E],
29, 35-41.
https://doi.org/10.22203/eCM.v029a03Niemansburg, S. L., Habets, M. G. J. L.
, Dhert, W. J. A., van Delden, J. J. M., & Bredenoord, A. L. (2015).
Participant selection for preventive Regenerative Medicine trials: ethical challenges of selecting individuals at risk.
Journal of Medical Ethics,
41(11), 914-6.
https://doi.org/10.1136/medethics-2014-102625Boot, W., Moojen, D. J. F., Visser, E., Lehr, A. M., De Windt, T. S., Van Hellemondt, G., Geurts, J., Tulp, N. J. A., Schreurs, B. W., Burger, B. J.
, Dhert, W. J. A., Gawlitta, D., & Vogely, H. C. (2015).
Missed low-grade infection in suspected aseptic loosening has no consequences for the survival of total hip arthroplasty.
Acta Orthopaedica,
86(6), 678-83.
https://doi.org/10.3109/17453674.2015.1086942Visser, J., Melchels, F. P. W., Mancini, I. A. D., Brommer, H., Jeon, J. E., Dalton, P. D., Dhert, W. J. A., Saris, D. B. F., Hutmacher, D. W., van Weeren, P. R., & Malda, J. (2015). Reinforced gelatin hydrogels for cartilage repair; from in vitro testing to implantation in the equine stifle join. In Reinforced gelatin hydrogels for cartilage repair; from in vitro testing to implantation in the equine stifle join
Visser, J., Melchers, F., Mancini, I. A. D., Brommer, H., Jeon, J. E., Dalton, P., Dhert, W. J. A., Saris, D. B. F., Hutmacher, D. W., van Weeren, P. R., & Malda, J. (2015). Reinforced gelatin hydrogels for cartilage repair: from in vitro testing to implantation in the equine knee joint. In Reinforced gelatin hydrogels for cartilage repair: from in vitro testing to implantation in the equine knee joint
Visser, J., Gawlitta, D., Benders, K. E. M., Toma, S. M. H., Pouran, B.
, van Weeren, P. R., Dhert, W. J. A., & Malda, J. (2015).
Endochondral bone formation in gelatin methacrylamide hydrogel with embedded cartilage-derived matrix particles.
Biomaterials,
37, 174-182.
https://doi.org/10.1016/j.biomaterials.2014.10.020 Visser, J., Levett, P. A.
, te Moller, N. C. R., Besems, J.
, Boere, K. W. M., van Rijen, M. H. P.
, de Grauw, J. C., Dhert, W. J. A., van Weeren, P. R., & Malda, J. (2015).
Crosslinkable Hydrogels Derived from Cartilage, Meniscus, and Tendon Tissue.
Tissue Engineering. Part A,
21(7-8), 1195-1206.
https://doi.org/10.1089/ten.tea.2014.0362 de Windt, T. S., Saris, D. B. F., Slaper-Cortenbach, I. C. M., van Rijen, M. H. P., Gawlitta, D., Creemers, L. B., de Weger, R. A.
, Dhert, W. J. A., & Vonk, L. A. (2015).
Direct Cell-Cell Contact with Chondrocytes Is a Key Mechanism in Multipotent Mesenchymal Stromal Cell-Mediated Chondrogenesis.
Tissue Engineering. Part A,
21(19-20), 2536-2547.
https://doi.org/10.1089/ten.TEA.2014.0673Croes, M., Oner, F. C., Kruyt, M. C., Blokhuis, T. J., Bastian, O.
, Dhert, W. J. A., & Alblas, J. (2015).
Proinflammatory Mediators Enhance the Osteogenesis of Human Mesenchymal Stem Cells after Lineage Commitment.
PLoS One,
10(7), [e0132781].
https://doi.org/10.1371/journal.pone.0132781Willems, N., Yang, H-Y., Langelaan, M. L. P.
, Tellegen, A. R., Grinwis, G. C. M., Kranenburg, H-J. C., Riemers, F. M., Plomp, S. G. M., Craenmehr, E. G. M.
, Dhert, W. J. A., Papen-Botterhuis, N. E.
, Meij, B. P., Creemers, L. B.
, & Tryfonidou, M. (2015).
Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model.
Arthritis Research & Therapy,
17(1), 214.
https://doi.org/10.1186/s13075-015-0727-x Yang, H-Y., van Ee, R. J., Timmer, K., Craenmehr, E. G. M., Huang, J. H., Öner, F. C.
, Dhert, W. J. A., Kragten, A. H. M.
, Willems, N., Grinwis, G. C. M., Tryfonidou, M. A., Papen-Botterhuis, N. E., & Creemers, L. B. (2015).
A novel injectable thermoresponsive and cytocompatible gel of poly(N-isopropylacrylamide) with layered double hydroxides facilitates siRNA delivery into chondrocytes in 3D culture.
Acta Biomaterialia.
https://doi.org/10.1016/j.actbio.2015.05.018Janssen, S. J., Bredenoord, A. L.
, Dhert, W., de Kleuver, M., Oner, F. C., & Verlaan, J-J. (2015).
Potential Conflicts of Interest of Editorial Board Members from Five Leading Spine Journals.
PLoS One,
10(6), [e0127362].
https://doi.org/10.1371/journal.pone.0127362Willems, N., Bach, F. C., Plomp, S. G. M., van Rijen, M. H., Wolfswinkel, J.
, Grinwis, G. C., Bos, C., Strijkers, G. J.
, Dhert, W. J., Meij, B. P., Creemers, L. B.
, & Tryfonidou, M. A. (2015).
Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration.
Arthritis Research & Therapy,
17, 1-14. [137].
https://doi.org/10.1186/s13075-015-0625-2 Niemansburg, S. L.
, van Delden, J. J. M., Dhert, W. J. A., & Bredenoord, A. L. (2015).
Reconsidering the ethics of sham interventions in an era of emerging technologies.
Surgery,
157(4), 801-10.
https://doi.org/10.1016/j.surg.2014.12.001Loozen, L. D., van der Helm, Y. J. M., Öner, F. C.
, Dhert, W. J. A., Kruyt, M. C., & Alblas, J. (2015).
Bone morphogenetic protein-2 nonviral gene therapy in a goat iliac crest model for bone formation.
Tissue Engineering. Part A,
21(9-10), 1672-9.
https://doi.org/10.1089/ten.TEA.2014.0593Krouwels, A., Popov-Celeketic, J.
, Plomp, S. G. M., Dhert, W. J. A., Öner, F. C., Bank, R. A., & Creemers, L. B. (2015).
No effects of Hyperosmolar Culture medium on Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells despite Upregulation Extracellular Matrix Genes.
Spine.
https://doi.org/10.1097/BRS.0000000000000920Visser, J., Melchels, F. P. W., Jeon, J. E., van Bussel, E. M., Kimpton, L. S., Byrne, H. M.
, Dhert, W. J. A., Dalton, P. D., Hutmacher, D. W.
, & Malda, J. (2015).
Reinforcement of hydrogels using three-dimensionally printed microfibres.
Nature Communications [E],
6, [6933].
https://doi.org/10.1038/ncomms7933Schuurman, W., Klein, T. J.
, Dhert, W. J. A., van Weeren, P. R., Hutmacher, D. W.
, & Malda, J. (2015).
Cartilage regeneration using zonal chondrocyte subpopulations: a promising approach or an overcomplicated strategy? Journal of Tissue Engineering and Regenerative Medicine,
9(6), 669-678.
https://doi.org/10.1002/term.1638 Rutgers, M., Creemers, L. B., Yang, K. G. A., Raijmakers, N. J. H.
, Dhert, W. J. A., & Saris, D. B. F. (2015).
Osteoarthritis treatment using autologous conditioned serum after placebo.
Acta Orthopaedica,
86(1), 114–118.
https://doi.org/10.3109/17453674.2014.950467de Windt, T. S., Vonk, L. A., Buskermolen, J. K.
, Visser, J., Karperien, M., Bleys, R. L. A. W.
, Dhert, W. J. A., & Saris, D. B. F. (2015).
Arthroscopic airbrush assisted cell implantation for cartilage repair in the knee: a controlled laboratory and human cadaveric study.
Osteoarthritis and Cartilage,
23(1), 143-150.
https://doi.org/10.1016/j.joca.2014.09.016Gawlitta, D., Benders, K. E. M., Visser, J., van der Sar, A. S., Kempen, D. H. R.
, Theyse, L. F. H., Malda, J., & Dhert, W. J. A. (2015).
Decellularized Cartilage-Derived Matrix as Substrate for Endochondral Bone Regeneration.
Tissue Engineering. Part A,
21(3-4), 694-703.
https://doi.org/10.1089/ten.TEA.2014.01172014
Scholarly publications
Krouwels, A., Iljas, L.
, Plomp, S., Dhert, W., Oner, C., & Creemers, L. B. (2014).
BMPs Enhance in Vitro Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells.
Global Spine Journal,
4(1_suppl), s-0034-1376562-s-0034-1376562.
https://doi.org/10.1055/s-0034-1376562Krouwels, A.
, Popov, J., Plomp, S., Dhert, W., Oner, C., Bank, R., & Creemers, L. (2014).
In Vitro Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells in Hyperosmotic Culture Medium.
Global Spine Journal,
4(1_suppl), s-0034-1376656-s-0034-1376656.
https://doi.org/10.1055/s-0034-1376656Benders, K. E. M., Boot, W.
, van Weeren, R., Gawlitta, D., Bergman, E., Saris, D. B. F.
, Dhert, W., & Malda, J. (2014).
Multipotent stromal cells outperform chondrocytes on cartilage-derived matrix scaffolds.
Cartilage,
5(4), 221-230.
https://doi.org/10.1177/1947603514535245Melchels, F. P. W., Dhert, W. J. A., Hutmacher, D. W.
, & Malda, J. (2014).
Development and characterisation of a new bioink for additive tissue manufacturing.
Journal of Materials Chemistry A,
2(16), 2282-2289.
https://doi.org/10.1039/c3tb21280g Wegman, F., Geuze, R. E., van der Helm, Y. J., Cumhur Öner, F.
, Dhert, W. J. A., & Alblas, J. (2014).
Gene delivery of bone morphogenetic protein-2 plasmid DNA promotes bone formation in a large animal model.
Journal of Tissue Engineering and Regenerative Medicine,
8(10), 763-70.
https://doi.org/10.1002/term.1571Eman, R. M., Oner, F. C., Kruyt, M. C.
, Dhert, W. J. A., & Alblas, J. (2014).
Stromal cell-derived factor-1 stimulates cell recruitment, vascularization and osteogenic differentiation.
Tissue Engineering. Part A,
20(3-4), 466-473.
https://doi.org/10.1089/ten.TEA.2012.0653Bekkers, J. E. J., Saris, D. B. F., Tsuchida, A. I., van Rijen, M. H. P.
, Dhert, W. J. A., & Creemers, L. B. (2014).
Chondrogenic potential of articular chondrocytes depends on their original location.
Tissue Engineering. Part A,
20(3-4), 663-71.
https://doi.org/10.1089/ten.TEA.2012.0673Niemansburg, S. L.
, van Delden, J. J. M., Oner, F. C.
, Dhert, W. J. A., & Bredenoord, A. L. (2014).
Ethical implications of regenerative medicine in orthopedics: an empirical study with surgeons and scientists in the field.
The Spine Journal,
14(6), 1029-35.
https://doi.org/10.1016/j.spinee.2013.10.016Vonk, L. A., Kragten, A. H. M.
, Dhert, W. J. A., Saris, D. B. F., & Creemers, L. B. (2014).
Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes.
Osteoarthritis and Cartilage,
22(1), 145-53.
https://doi.org/10.1016/j.joca.2013.11.006 Yang, H.
, Vonk, L. A., Licht, R., van Boxtel, A. M. G., Bekkers, J. E. J., Kragten, A. H. M., Hein, S., Varghese, O. P., Howard, K. A., Öner, F. C.
, Dhert, W. J. A., & Creemers, L. B. (2014).
Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells.
European Journal of Pharmaceutical Sciences,
53, 35-44.
https://doi.org/10.1016/j.ejps.2013.12.006Kock, L. M.
, Malda, J., Dhert, W. J. A., Ito, K., & Gawlitta, D. (2014).
Flow-perfusion interferes with chondrogenic and hypertrophic matrix production by mesenchymal stem cells.
Journal of Biomechanics,
47(9), 2122-2129.
https://doi.org/10.1016/j.jbiomech.2013.11.006Poldervaart, M. T., Gremmels, H., van Deventer, K., Fledderus, J. O., Oner, F. C., Verhaar, M. C.
, Dhert, W. J. A., & Alblas, J. (2014).
Prolonged presence of VEGF promotes vascularization in 3D bioprinted scaffolds with defined architecture.
Journal of Controlled Release,
184, 58-66.
https://doi.org/10.1016/j.jconrel.2014.04.007Eman, R. M., Hoorntje, E. T., Oner, F. C., Kruyt, M. C.
, Dhert, W. J. A., & Alblas, J. (2014).
CXCL12/Stromal-Cell-Derived Factor-1 Effectively Replaces Endothelial Progenitor Cells to Induce Vascularized Ectopic Bone.
Stem Cells and Development,
23(24), 2950-8.
https://doi.org/10.1089/scd.2013.0560Vonk, L. A., de Windt, T. S., Kragten, A. H. M., Beekhuizen, M., Mastbergen, S. C.
, Dhert, W. J. A., Lafeber, F. P. J. G., Creemers, L. B., & Saris, D. B. F. (2014).
Enhanced cell-induced articular cartilage regeneration by chondrons; the influence of joint damage and harvest site.
Osteoarthritis and Cartilage,
22(11), 1910-7.
https://doi.org/10.1016/j.joca.2014.08.005 Yang, H-Y.
, van Dijk, M., Licht, R., Beekhuizen, M., van Rijen, M., Janstål, M. K., Oner, F. C.
, Dhert, W. J. A., Schumann, D., & Creemers, L. B. (2014).
Applicability of a Newly Developed Bioassay for Determining Bioactivity of Anti-Inflammatory Compounds in Release Studies - Celecoxib and Triamcinolone Acetonide Released from Novel PLGA-Based Microspheres.
Pharmaceutical Research,
2015(32), 680-690.
https://doi.org/10.1007/s11095-014-1495-zTsuchida, A. I., Beekhuizen, M., T Hart, M. C., Radstake, T.
, Dhert, W., Saris, D., van Osch, G., & Creemers, L. B. (2014).
Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes.
Arthritis Research & Therapy,
16(5).
https://doi.org/10.1186/s13075-014-0441-0Prins, H. J., Braat, A. K., Gawlitta, D.
, Dhert, W. J. A., Egan, D. A., Tijssen-Slump, E., Yuan, H., Coffer, P. J., Rozemuller, H., & Martens, A. C. M. (2014).
In vitro induction of alkaline phosphatase levels predicts in vivo bone forming capacity of human bone marrow stromal cells. Stem Cell Research,
12, 428-440.
https://doi.org/10.1016/j.scr.2013.12.0012013
Scholarly publications
Verlaan, J-J.
, Dhert, W. J. A., & Oner, F. C. (2013).
Intervertebral disc viability after burst fractures of the thoracic and lumbar spine treated with pedicle screw fixation and direct end-plate restoration.
The Spine Journal,
13(3), 217-21.
https://doi.org/10.1016/j.spinee.2012.02.032Niemansburg, S. L.
, van Delden, J. J., Dhert, W. JA., & Bredenoord, A. L. (2013).
Regenerative medicine interventions for orthopedic disorders: ethical issues in the translation into patients.
Regenerative Medicine,
8(1), 65-73.
https://doi.org/10.2217/rme.12.112Mentink, A., Hulsman, M., Groen, N., Licht, R., Dechering, K. J., van der Stok, J., Alves, H. A.
, Dhert, W. JA., van Someren, E. P., Reinders, M. J. T., van Blitterswijk, C. A., & de Boer, J. (2013).
Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1.
Biomaterials,
34(19), 4592-4601.
https://doi.org/10.1016/j.biomaterials.2013.03.001Verlaan, J-J., Somers, I.
, Dhert, W. J. A., & Oner, F. C. (2013).
Clinical and radiological results 6 years after treatment of traumatic thoracolumbar burst fractures with pedicle screw instrumentation and balloon assisted end plate reduction.
The Spine Journal.
https://doi.org/10.1016/j.spinee.2013.11.044Bekkers, J. E. J., Bartels, L. W., Benink, R. J., Tsuchida, A. I., Vincken, K. L.
, Dhert, W. J. A., Creemers, L. B., & Saris, D. B. F. (2013).
Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) can be effectively applied for longitudinal cohort evaluation of articular cartilage regeneration.
Osteoarthritis and Cartilage,
21(7), 943-949.
https://doi.org/10.1016/j.joca.2013.03.017Schuurman, W., Harimulyo, E. B., Gawlitta, D., Woodfield, T. B. F.
, Dhert, W. J. A., van Weeren, P. R., & Malda, J. (2013).
Three-dimensional assembly of tissue-engineered cartilage constructs results in cartilaginous tissue formation without retainment of zonal characteristics.
Journal of Tissue Engineering and Regenerative Medicine,
10(4), 315-324.
https://doi.org/10.1002/term.1726 Halma, J. J., Vogely, H. C.
, Dhert, W. J., Van Gaalen, S. M., & de Gast, A. (2013).
Do monoblock cups improve survivorship, decrease wear, or reduce osteolysis in uncemented total hip arthroplasty? Clinical Orthopaedics and Related Research,
471(11), 3572-80.
https://doi.org/10.1007/s11999-013-3144-y2012
Scholarly publications
Seyednejad, H., Ji, W., Yang, F.
, Van Nostrum, C. F., Vermonden, T., Van Den Beucken, J. J. J. P.
, Dhert, W. J. A., Hennink, W. E., & Jansen, J. A. (2012).
Coaxially electrospun scaffolds based on hydroxyl-functionalized poly(ε-caprolactone) and loaded with VEGF for tissue engineering applications.
Biomacromolecules,
13(11), 3650-3660.
https://doi.org/10.1021/bm301101r Seyednejad, H., Gawlitta, D.
, Kuiper, R. V., de Bruin, A., van Nostrum, C. F., Vermonden, T., Dhert, W. J. A., & Hennink, W. E. (2012).
In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly(ε-caprolactone).
Biomaterials,
33(17), 4309-18.
https://doi.org/10.1016/j.biomaterials.2012.03.002 Geuze, R. E.
, Theyse, L. F. H., Kempen, D. H. R.
, Hazewinkel, H. A. W., Kraak, H. Y. A., Oner, F. C.
, Dhert, W. J. A., & Alblas, J. (2012).
A differential effect of bone morphogenetic protein-2 and vascular endothelial growth factor release timing on osteogenesis at ectopic and orthotopic sites in a large-animal model.
Tissue Engineering - Part A.,
18(19-20), 2052-62.
https://doi.org/10.1089/ten.TEA.2011.0560Smolders, L. A., Kingma, I.
, Bergknut, N., van der Veen, A. J.
, Dhert, W. J. A., Hazewinkel, H. A. W., van Dieen, J. H.
, & Meij, B. P. (2012).
Biomechanical assessment of the effects of decompressive surgery in non-chondrodystrophic and chondrodystrophic canine multisegmented lumbar spines. European Spine Journal,
21(9), 1692-1699.
http://www.ncbi.nlm.nih.gov/pubmed/22492242 2011
Scholarly publications
Fujishiro, T., Moojen, D. J. F., Kobayashi, N.
, Dhert, W. J. A., & Bauer, T. W. (2011).
Perivascular and diffuse lymphocytic inflammation are not specific for failed metal-on-metal hip implants.
Clinical Orthopaedics and Related Research,
469(4), 1127-33.
https://doi.org/10.1007/s11999-010-1649-1Verlaan, J. J., Westerveld, L. A.
, van Keulen, J. W., Bleys, R. L. A. W.
, Dhert, W. J., van Herwaarden, J. A., Moll, F. L., & Oner, F. C. (2011).
Quantitative analysis of the anterolateral ossification mass in diffuse idiopathic skeletal hyperostosis of the thoracic spine.
European Spine Journal,
20(9), 1474-9.
https://doi.org/10.1007/s00586-011-1719-4Beekhuizen, M., Bastiaansen-Jenniskens, Y. M., Koevoet, W., Saris, D. B. F.
, Dhert, W. J. A., Creemers, L. B., & van Osch, G. J. V. M. (2011).
Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: establishment and characterization of a long-term cartilage-synovium coculture.
Arthritis and Rheumatism,
63(7), 1918-27.
https://doi.org/10.1002/art.30364Fedorovich, N. E., Wijnberg, H. M.
, Dhert, W. J. A., & Alblas, J. (2011).
Distinct tissue formation by heterogeneous printing of osteo- and endothelial progenitor cells.
Tissue Engineering - Part A.,
17(15-16), 2113-21.
https://doi.org/10.1089/ten.TEA.2011.0019Verlaan, J-J., Boswijk, P. F. E., de Ru, J. A.
, Dhert, W. J. A., & Oner, F. C. (2011).
Diffuse idiopathic skeletal hyperostosis of the cervical spine: an underestimated cause of dysphagia and airway obstruction.
Spine Journal,
11(11), 1058-67.
https://doi.org/10.1016/j.spinee.2011.09.0142010
Scholarly publications
Delawi, D.
, Dhert, W. J. A., Rillardon, L., Gay, E., Prestamburgo, D., Garcia-Fernandez, C., Guerado, E., Specchia, N., Van Susante, J. L. C., Verschoor, N., van Ufford, H. M. E. Q., & Oner, F. C. (2010).
A prospective, randomized, controlled, multicenter study of osteogenic protein-1 in instrumented posterolateral fusions: report on safety and feasibility.
Spine,
35(12), 1185-91.
https://doi.org/10.1097/BRS.0b013e3181d3cf28Kempen, D. H. R., Lu, L., Hefferan, T. E., Creemers, L. B., Heijink, A., Maran, A.
, Dhert, W. J. A., & Yaszemski, M. J. (2010).
Enhanced bone morphogenetic protein-2-induced ectopic and orthotopic bone formation by intermittent parathyroid hormone (1-34) administration.
Tissue Engineering - Part A.,
16(12), 3769-77.
https://doi.org/10.1089/ten.TEA.2010.0173Moojen, D. J. F., van Hellemondt, G., Vogely, H. C., Burger, B. J., Walenkamp, G. H. I. M., Tulp, N. J. A., Schreurs, B. W., de Meulemeester, F. R. A. J., Schot, C. S., van de Pol, I., Fujishiro, T., Schouls, L. M., Bauer, T. W.
, & Dhert, W. J. A. (2010).
Incidence of low-grade infection in aseptic loosening of total hip arthroplasty.
Acta Orthopaedica,
81(6), 667-73.
https://doi.org/10.3109/17453674.2010.5252012008
Scholarly publications
Malda, J., Rouwkema, J., Leeuwenburgh, S. C. G.
, Dhert, W. J. A., & Kirkpatrick, C. J. (2008).
Crossing frontiers in biomaterials and regenerative medicine. 8th World Biomaterials Congress, 28 May - 1 June, Amsterdam, The Netherlands.
Regenerative Medicine,
3(5), 765-8.
https://doi.org/10.2217/17460751.3.5.765 Leeuwenburgh, S. C. G.
, Jansen, J. A., Malda, J., Dhert, W. A., Rouwkema, J., van Blitterswijk, C. A., Kirkpatrick, C. J., & Williams, D. F. (2008).
Trends in biomaterials research: An analysis of the scientific programme of the World Biomaterials Congress 2008.
Biomaterials,
29(21), 3047-52.
https://doi.org/10.1016/j.biomaterials.2008.04.032Fedorovich, N., Van Geemen, D., Oudshoorn, M., Hennink, W., Alblas, J., & Dhert, W. (2008). Applicability of photopolymerizable hydrogels for bone tissue printing. In 8th World Biomaterials Congress 2008 (Vol. 4)
Vermonden, T., Fedorovich, N. E., Van Geemen, D., Alblas, J., Van Nostrum, C. F., Dhert, W. J. A., & Hennink, W. E. (2008). Degradation behavior and cytocompatibility of photopolymerized thermosensitive hydrogels. In 8th World Biomaterials Congress 2008 (Vol. 4)
2002
Scholarly publications
Öner, F. C., van Gils, A., Faber, J. A. J., Dhert, W. J. A., & Verbout, A. J. (2002). Some complications of common treatment schemes of thoracolumbar spine fractures can be predicted with magnetic resonance imaging: prospective study of 53 patients with 71 fractures. Spine, 27, 629-636.