prof. dr. ir. W.E. (Wim) Hennink
W.E.Hennink@uu.nl
Head of Department
Pharmaceutical sciences - Pharmaceutics
Gegenereerd op 2018-06-20 23:01:11


Chair
Pharmaceutics
Profile

Polymeric drug delivery systems

  • Best Paper Award, European Journal of Pharmaceutical Sciences, 2005 
  • Promotor of the year, Utrecht University, 2008
Gegenereerd op 2018-06-20 23:01:11
Curriculum vitae Download PDF
Gegenereerd op 2018-06-20 23:01:11
All publications
  2018 - Scholarly publications
Martínez-Jothar, Lucía, Doulkeridou, Sofia, Schiffelers, Raymond M, Torano, Javier Sastre, Oliveira, Sabrina, van Nostrum, Cornelus F & Hennink, Wim E (2018). Insights into maleimide - thiol conjugation chemistry - conditions for efficient surface functionalization of nanoparticles for receptor targeting. Journal of Controlled Release Copyright © 2018. Published by Elsevier B.V..
Kostadinova, Atanaska I, Middelburg, Jim, Ciulla, Michele, Garssen, Johan, Hennink, Wim E, Knippels, Leon M J, van Nostrum, Cornelus F & Willemsen, Linette E M (05.01.2018). PLGA nanoparticles loaded with beta-lactoglobulin-derived peptides modulate mucosal immunity and may facilitate cow's milk allergy prevention. European Journal of Pharmacology, 818, (pp. 211-220) (10 p.). Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved..
  2017 - Scholarly publications
O'Neill, Hugh S., Herron, Caroline C., Hastings, Conn L., Deckers, Roel, Lopez Noriega, Adolfo, Kelly, Helena M., Hennink, Wim E., McDonnell, Ciarán O., O'Brien, Fergal J., Ruiz-Hernández, Eduardo & Duffy, Garry P. (15.01.2017). A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents. Acta Biomaterialia, 48, (pp. 110-119) (10 p.).
Alaarg, Amr, Senders, Max L., Varela-Moreira, Aida, Pérez-Medina, Carlos, Zhao, Yiming, Tang, Jun, Fay, Francois, Reiner, Thomas, Fayad, Zahi A., Hennink, Wim E., Metselaar, Josbert M., Mulder, Willem J.M. & Storm, G (28.09.2017). A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis. Journal of Controlled Release, 262, (pp. 47-57) (11 p.).
Kasmi, Sabah, Louage, Benoit, Nuhn, Lutz, Verstraete, Glenn, Van Herck, Simon, Van Steenbergen, Mies J., Vervaet, Chris, Hennink, Wim E. & De Geest, Bruno G. (14.11.2017). Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization. Polymer Chemistry, 8 (42), (pp. 6544-6557) (14 p.).
Ribeiro, Alexandre, Blokzijl, Maarten Michiel, Levato, Riccardo, Visser, Claas Willem, Castilho, Miguel, Hennink, Wim E, Vermonden, Tina & Malda, Jos (30.11.2017). Assessing bioink shape fidelity to aid material development in 3D bioprinting. Biofabrication, 10 (9 p.). © 2017 IOP Publishing Ltd..
Rehor, Ivan, van Vreeswijk, Sophie, Vermonden, Tina, Hennink, Wim E., Kegel, Willem K. & Eral, Huseyin Burak (18.10.2017). Biodegradable Microparticles for Simultaneous Detection of Counterfeit and Deteriorated Edible Products. Small, 13 (39) (9 p.).
Varela Moreira, A.A., Shi, Y., Fens, M.H.A.M., Lammers, T.G.G.M., Hennink, W.E. & Schiffelers, R.M. (01.08.2017). Clinical application of polymeric micelles for the treatment of cancer. Materials Chemistry Frontiers, 1 (8), (pp. 1485-1501) (17 p.).
Sandker, Maria J., Duque, Luisa F., Redout, Everaldo M., Chan, Alan, Que, Ivo, Löwik, Clemens W G M, Klijnstra, Evelien C., Kops, Nicole, Steendam, Rob, van Weeren, René, Hennink, Wim E. & Weinans, Harrie (15.01.2017). Degradation, intra-articular retention and biocompatibility of monospheres composed of [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers. Acta Biomaterialia, 48, (pp. 401-414) (14 p.).
Mouser, Vivian Hilda Maria, Abbadessa, Anna, Levato, Riccardo, Hennink, Wim, Vermonden, Tina, Gawlitta, Debby & Malda, Jos (23.02.2017). Development of a thermosensitive HAMA-containing bio-ink for the fabrication of composite cartilage repair constructs. Biofabrication, 9 (1) (13 p.). © 2017 IOP Publishing Ltd..
Chen, Weiluan, Palazzo, Amelia, Hennink, Wim E. & Kok, Robbert J. (06.02.2017). Effect of particle size on drug loading and release kinetics of gefitinib-loaded PLGA microspheres. Molecular Pharmaceutics, 14 (2), (pp. 459-467) (9 p.).
Gholizadeh Soltani, Shima, Visweswaran, Ganesh Ram R, Storm, G, Hennink, Wim E., Kamps, Jan A A M & Kok, Robbert J. (13.10.2017). E-selectin targeted immunoliposomes for rapamycin delivery to activated endothelial cells. International Journal of Pharmaceutics
Span, Kimberley, Pieters, Ebel H E, Brinks, Vera, Hennink, Wim E & Schellekens, Huub (24.12.2017). Evaluation of the suitability of a Sprague Dawley rat model to assess intravenous iron preparations. Journal of Pharmacological and Toxicological Methods, 91, (pp. 7-17) (11 p.). Copyright © 2017 Elsevier Inc. All rights reserved..
Chen, Weiluan, di Carlo, Chiara, Devery, Donal, McGrath, Donnacha J., McHugh, Peter E., Kleinsteinberg, Kathrin, Jockenhoevel, Stefan, Hennink, Wim E. & Kok, Robbert J. (2017). Fabrication and characterization of gefitinib-releasing polyurethane foam as a coating for drug-eluting stent in the treatment of bronchotracheal cancer. International Journal of Pharmaceutics
Chen, Weiluan, Clauser, Johanna, Thiebes, Anja Lena, McGrath, Donnacha J., Kelly, Nicola, van Steenbergen, Mies J., Jockenhoevel, Stefan, Steinseifer, Ulrich, McHugh, Peter E., Hennink, Wim E. & Kok, Robbert J. (30.05.2017). Gefitinib/gefitinib microspheres loaded polyurethane constructs as drug-eluting stent coating. European Journal of Pharmaceutical Sciences, 103, (pp. 94-103) (10 p.).
Buwalda, Sytze J., Vermonden, Tina & Hennink, Wim E. (13.02.2017). Hydrogels for Therapeutic Delivery - Current Developments and Future Directions. Biomacromolecules, 18 (2), (pp. 316-330) (15 p.).
Chen, Yinan, Dakwar, George R., Braeckmans, Kevin, Lammers, Twan, Hennink, Wim E. & Metselaar, Josbert M. (20.11.2017). In Vitro Evaluation of Anti-Aggregation and Degradation Behavior of PEGylated Polymeric Nanogels under In Vivo Like Conditions. Macromolecular Bioscience
Martín-Saavedra, Francisco, Ruiz-Hernández, Eduardo, Escudero-Duch, Clara, Prieto, Martín, Arruebo, Manuel, Sadeghi, Negar, Deckers, Roel, Storm, G, Hennink, Wim E., Santamaría, Jesús & Vilaboa, Nuria (01.10.2017). Lipogels responsive to near-infrared light for the triggered release of therapeutic agents. Acta Biomaterialia, 61, (pp. 54-65) (12 p.).
Wennink, Jos W.H., Liu, Yanna, Mäkinen, Petri I., Setaro, Francesca, de la Escosura, Andrès, Bourajjaj, Meriem, Lappalainen, Jari P., Holappa, Lari P., van den Dikkenberg, Joep B., al Fartousi, Mina, Trohopoulos, Panagiotis N., Ylä-Herttuala, Seppo, Torres, Tomas, Hennink, Wim E. & van Nostrum, Cornelus F. (30.09.2017). Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles - A possible treatment for cardiovascular diseases. European Journal of Pharmaceutical Sciences, 107, (pp. 112-125) (14 p.).
Li, Dandan, van Nostrum, Cornelus F, Mastrobattista, Enrico, Vermonden, Tina & Hennink, Wim E (10.08.2017). Nanogels for intracellular delivery of biotherapeutics. Journal of Controlled Release, 259, (pp. 16-28) (13 p.). Copyright © 2016 Elsevier B.V. All rights reserved..
Chen, Y., Tezcan, Okan, Li, D., Beztsinna, N., Lou, B., Etrych, T., Ulbrich, K., Metselaar, J. M., Lammers, T. & Hennink, W. E. (07.08.2017). Overcoming multidrug resistance using folate receptor-targeted and pH-responsive polymeric nanogels containing covalently entrapped doxorubicin. Nanoscale, 9 (29), (pp. 10404-10419) (16 p.).
Gholizadeh Soltani, Shima, Kamps, Jan A A M, Hennink, Wim E & Kok, Robbert J (2017). PLGA-PEG nanoparticles for targeted delivery of the mTOR/PI3kinase inhibitor dactolisib to inflamed endothelium. International Journal of Pharmaceutics Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved..
Kordalivand, Neda, Li, Dandan, Beztsinna, Nataliia, Sastre Torano, Javier, Mastrobattista, Enrico, van Nostrum, Cornelus F., Hennink, Wim E. & Vermonden, Tina (15.12.2017). Polyethyleneimine coated nanogels for the intracellular delivery of RNase A for cancer therapy. Chemical Engineering Journal
Li, Dandan, Chen, Yinan, Mastrobattista, Enrico, Van Nostrum, Cornelus F., Hennink, Wim E. & Vermonden, Tina (2017). Reduction-sensitive polymer-shell-coated nanogels for intracellular delivery of antigens. ACS Biomaterials Science and Engineering, 3 (1), (pp. 42-48) (7 p.).
Radmalekshahi, Mazda, Fransen, Marieke F, Krawczyk, Małgorzata, Mansourian, Mersedeh, Bourajjaj, Meriem, Chen, Jian, Ossendorp, Ferry, Hennink, Wim E, Mastrobattista, Enrico & Amidi, Maryam (27.01.2017). Self-Assembling Peptide Epitopes as Novel Platform for Anticancer Vaccination. Molecular Pharmaceutics, 14, (pp. 1482-1493).
Bakhshandeh, S., Gorgin Karaji, Z., Lietaert, K., Fluit, Ad C, Boel, C. H.E., Vogely, H Charles, Vermonden, T., Hennink, W. E., Weinans, H., Zadpoor, Amir A & Amin Yavari, S. (09.08.2017). Simultaneous Delivery of Multiple Antibacterial Agents from Additively Manufactured Porous Biomaterials to Fully Eradicate Planktonic and Adherent Staphylococcus aureus. ACS Applied Materials and Interfaces, 9 (31), (pp. 25691-25699) (9 p.).
Lou, Bo, Beztsinna, Nataliia, Mountrichas, Grigoris, van den Dikkenberg, Joep B., Pispas, Stergios & Hennink, Wim E. (20.06.2017). Small nanosized poly(vinyl benzyl trimethylammonium chloride) based polyplexes for siRNA delivery. International Journal of Pharmaceutics, 525 (2), (pp. 388-396) (9 p.).
Abbadessa, Anna, Landín, Mariana, Oude Blenke, Erik, Hennink, Wim E. & Vermonden, Tina (01.07.2017). Two-component thermosensitive hydrogels - Phase separation affecting rheological behavior. European Polymer Journal, 92, (pp. 13-26) (14 p.).
  2016 - Scholarly publications
Liu, Jia, Hennink, Wim E., Van Steenbergen, Mies J., Zhuo, Renxi & Jiang, Xulin (2016). A facile modular approach toward multifunctional supramolecular polyplexes for targeting gene delivery. Journal of Materials Chemistry C, 4 (43), (pp. 7022-7030) (9 p.).
Naksuriya, Ornchuma, van Steenbergen, Mies J., Sastre Torano, Javier, Okonogi, Siriporn & Hennink, Wim E. (2016). A Kinetic Degradation Study of Curcumin in Its Free Form and Loaded in Polymeric Micelles. AAPS Journal, 18 (3), (pp. 777-787) (11 p.).
Sun, Feilong, Jaspers, Tessa C C, van Hasselt, Peter M., Hennink, Wim E. & van Nostrum, Cornelus F. (01.09.2016). A Mixed Micelle Formulation for Oral Delivery of Vitamin K. Pharmaceutical Research, 33 (9), (pp. 2168-2179) (12 p.).
Span, Kimberley, Verhoef, Johan J F, Hunt, Hedi, van Nostrum, Cornelus F., Brinks, Vera, Schellekens, Huub & Hennink, Wim E. (2016). A novel oral iron-complex formulation - Encapsulation of hemin in polymeric micelles and its in vitro absorption. European Journal of Pharmaceutics and Biopharmaceutics, 108, (pp. 226-234) (9 p.).
Abbadessa, Anna, Mouser, Vivian H M, Blokzijl, Maarten M, Gawlitta, Debby, Dhert, Wouter J A, Hennink, Wim E, Malda, Jos & Vermonden, Tina (13.06.2016). A Synthetic Thermosensitive Hydrogel for Cartilage Bioprinting and Its Biofunctionalization with Polysaccharides. Biomacromolecules, 17 (6), (pp. 2137-2147).
Abbadessa, A, Blokzijl, M M, Mouser, V H M, Marica, P, Malda, J, Hennink, W E & Vermonden, T (20.09.2016). A thermo-responsive and photo-polymerizable chondroitin sulfate-based hydrogel for 3D printing applications. Carbohydrate Polymers, 149, (pp. 163-174) (12 p.). Copyright © 2016 Elsevier Ltd. All rights reserved..
Shirangi, Mehrnoosh, Hennink, Wim E., Somsen, Govert W. & Van Nostrum, Cornelus F. (01.02.2016). Acylation of arginine in goserelin-loaded PLGA microspheres. European Journal of Pharmaceutics and Biopharmaceutics, 99, (pp. 18-23) (6 p.).
Radmalekshahi, Mazda, Lempsink, Ludwijn, Amidi, Maryam, Hennink, Wim E. & Mastrobattista, Enrico (20.01.2016). Biomedical Applications of Self-Assembling Peptides. Bioconjugate Chemistry, 27 (1), (pp. 3-18) (16 p.).
Lammers, Twan, Kiessling, Fabian, Ashford, Marianne, Hennink, Wim, Crommelin, Daan & Storm, G (2016). Cancer nanomedicine - Is targeting our target?. Nature Materials, 1 (9).
Hu, Qizhi, Prakash, Jai, Rijcken, Cristianne J F, Hennink, Wim E. & Storm, G (30.11.2016). High systemic availability of core-crosslinked polymeric micelles after subcutaneous administration. International Journal of Pharmaceutics, 514 (1), (pp. 112-120) (9 p.).
Melchels, Ferry P W, Blokzijl, Maarten M, Levato, Riccardo, Peiffer, Quentin C, Ruijter, Mylène de, Hennink, Wim E, Vermonden, Tina & Malda, Jos (2016). Hydrogel-based reinforcement of 3D bioprinted constructs. Biofabrication, 8 (3).
Shirangi, Mehrnoosh, Najafi, Marzieh, Rijkers, Dirk T S, Kok, Robbert Jan, Hennink, Wim E & van Nostrum, Cornelus F (19.01.2016). Inhibition of Octreotide Acylation Inside PLGA Microspheres by Derivatization of the Amines of the Peptide with a Self-Immolative Protecting Group. Bioconjugate Chemistry, (pp. 576-585) (10 p.).
Ramazani, Farshad, van Nostrum, Cornelis F., Storm, G, Kiessling, Fabian, Lammers, Twan, Hennink, Wim E. & Kok, Robbert J. (2016). Locoregional cancer therapy using polymer-based drug depots. Drug Discovery Today, 21 (4), (pp. 640-647) (8 p.).
van Elk, Merel, Murphy, Bruce P, Eufrásio-da-Silva, Tatiane, O'Reilly, Daniel P, Vermonden, Tina, Hennink, Wim E, Duffy, Garry P & Ruiz-Hernández, Eduardo (30.12.2016). Nanomedicines for advanced cancer treatments - Transitioning towards responsive systems. International Journal of Pharmaceutics, 515 (1-2), (pp. 132-164) (33 p.). Copyright © 2016 Elsevier B.V. All rights reserved..
Zoetebier, B., Sohrabi, A., Lou, B., Hempenius, M. A., Hennink, W. E. & Vancso, G. J. (2016). PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery. Chemical Communications, 52 (49), (pp. 7707-7710) (4 p.).
Chen, Yinan, van Steenbergen, Mies J., Li, Dandan, van den Dikkenberg, Joep, Lammers, Twan, van Nostrum, Cornelus F., Metselaar, Josbert M. & Hennink, Wim E. (01.08.2016). Polymeric Nanogels with Tailorable Degradation Behavior. Macromolecular Bioscience, 16 (8), (pp. 1122-1137) (16 p.).
Marinelli, Lisa, Cacciatore, Ivana, Fornasari, Erika, Gasbarri, Carla, Angelini, Guido, Marrazzo, Agostino, Pandolfi, Assunta, Mandatori, Domitilla, Shi, Yang, Van Nostrum, Cornelus F., Hennink, Wim E. & Di Stefano, Antonio (01.10.2016). Preparation and characterization of polymeric micelles loaded with a potential anticancer prodrug. Journal of Drug Delivery Science and Technology, 35, (pp. 24-29) (6 p.).
Chen, Weiluan, Clauser, Johanna, Thiebes, Anja Lena, McGrath, Donnacha J., McHugh, Peter E., Steinseifer, Ulrich, Jockenhoevel, Stefan, Hennink, Wim E. & Kok, Robbert Jan (30.11.2016). Selection and fabrication of a non-woven polycarbonate urethane cover for a tissue engineered airway stent. International Journal of Pharmaceutics, 514 (1), (pp. 255-262) (8 p.).
Ramazani, Farshad, Chen, Weiluan, van Nostrum, Cornelis F, Storm, G, Kiessling, Fabian, Lammers, Twan, Hennink, Wim E & Kok, Robbert J (12.01.2016). Strategies for encapsulation of small hydrophilic and amphiphilic drugs in PLGA microspheres - State-of-the-art and challenges. International Journal of Pharmaceutics, 499 (1-2), (pp. 358-367) (10 p.). Copyright © 2016 Elsevier B.V. All rights reserved..
Li, Dandan, Sun, Feilong, Bourajjaj, Meriem, Chen, Yinan, Pieters, Ebel H., Chen, Jian, Van Den Dikkenberg, Joep B., Lou, Bo, Camps, Marcel G M, Ossendorp, Ferry, Hennink, Wim E., Vermonden, Tina & Van Nostrum, Cornelus F. (21.12.2016). Strong - In vivo antitumor responses induced by an antigen immobilized in nanogels via reducible bonds. Nanoscale, 8 (47), (pp. 19592-19604) (13 p.).
Hu, Qizhi, Rijcken, Cristianne, van Gaal, Ethlinn, Brundel, Paul, Kostkova, Hana, Etrych, Tomas, Weber, Benjamin, Barz, Matthias, Kiessling, Fabian, Prakash, Jai, Storm, G, Hennink, Wim E. & Lammers, Twan (28.12.2016). Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications. Journal of Controlled Release, 244, (pp. 314-325) (12 p.).
Kasmi, Sabah, Louage, Benoit, Nuhn, Lutz, Van Driessche, Alexandra, Van Deun, Jan, Karalic, Izet, Risseeuw, Martijn, Van Calenbergh, Serge, Hoogenboom, Richard, De Rycke, Riet, De Wever, Olivier, Hennink, Wim E. & de Geest, B.G. (11.01.2016). Transiently responsive block copolymer micelles based on N-(2-hydroxypropyl)methacrylamide engineered with hydrolyzable ethylcarbonate side chains. Biomacromolecules, 17 (1), (pp. 119-127) (9 p.).
Priwitaningrum, Dwi L., Blondé, Jean Baptiste G, Sridhar, Adithya, van Baarlen, Joop, Hennink, Wim E., Storm, G, Le Gac, Séverine & Prakash, Jai (28.12.2016). Tumor stroma-containing 3D spheroid arrays - A tool to study nanoparticle penetration. Journal of Controlled Release, 244, (pp. 257-268) (12 p.).
Liu, Jia, Hennink, Wim E., Van Steenbergen, Mies J., Zhuo, Renxi & Jiang, Xulin (28.03.2016). Versatile Supramolecular Gene Vector Based on Host-Guest Interaction. Bioconjugate Chemistry, 27 (4), (pp. 1143-1152) (10 p.).
  2015 - Scholarly publications
Hu, Qizhi, Van Gaal, Ethlinn V B, Brundel, Paul, Ippel, Hans, Hackeng, Tilman, Rijcken, Cristianne J F, Storm, Gert, Hennink, Wim E. & Prakash, Jai (06.01.2015). A novel approach for the intravenous delivery of leuprolide using core-cross-linked polymeric micelles. Journal of Controlled Release, 205, (pp. 98-108) (11 p.).
Van Elk, Merel, Lorenzato, Cyril, Ozbakir, Burcin, Oerlemans, Chris, Storm, Gert, Nijsen, Frank, Deckers, Roel, Vermonden, Tina & Hennink, Wim E. (12.03.2015). Alginate microgels loaded with temperature sensitive liposomes for magnetic resonance imageable drug release and microgel visualization. European Polymer Journal, 72, (pp. 620-631) (12 p.).
van Elk, Merel, Ozbakir, Burcin Ulgen, Barten-Rijbroek, Angelique D., Storm, G, Nijsen, Frank, Hennink, Wim, Vermonden, Tina & Deckers, Roel (11.11.2015). Alginate Microspheres Containing Temperature Sensitive Liposomes (TSL) for MR-Guided Embolization and Triggered Release of Doxorubicin. PLoS One, 10 (11) (19 p.).
Shi, Yang, Cardoso, Renata M., Van Nostrum, Cornelus F. & Hennink, Wim E. (01.01.2015). Anthracene functionalized thermosensitive and UV-crosslinkable polymeric micelles. Polymer Chemistry, 6 (11), (pp. 2048-2053) (6 p.).
Kazazi-Hyseni, F., Zandstra, J., Popa, E. R., Goldschmeding, R., Lathuile, A. A R, Veldhuis, G. J., Van Nostrum, C. F., Hennink, W. E. & Kok, R. J. (30.03.2015). Biocompatibility of poly(d,l-lactic-co-hydroxymethyl glycolic acid) microspheres after subcutaneous and subcapsular renal injection. International Journal of Pharmaceutics, 482 (1-2), (pp. 99-109) (11 p.).
Boere, Kristel W. M., Blokzijl, Maarten M., Visser, Jetze, Linssen, J. Elder A., Malda, Jos, Hennink, Wim E. & Vermonden, Tina (2015). Biofabrication of reinforced 3D-scaffolds using two-component hydrogels. Journal of Materials Chemistry C, 3 (46), (pp. 9067-9078) (12 p.).
Martens, Thomas F., Remaut, Katrien, Deschout, Hendrik, Engbersen, Johan F J, Hennink, Wim E., Van Steenbergen, Mies J., Demeester, Jo, De Smedt, Stefaan C. & Braeckmans, Kevin (28.03.2015). Coating nanocarriers with hyaluronic acid facilitates intravitreal drug delivery for retinal gene therapy. Journal of Controlled Release, 202, (pp. 83-92) (10 p.).
Hu, Qizhi, Rijcken, Cristianne J., Bansal, Ruchi, Hennink, Wim E., Storm, Gert & Prakash, Jai (01.01.2015). Complete regression of breast tumour with a single dose of docetaxel-entrapped core-cross-linked polymeric micelles. Biomaterials, 53, (pp. 370-378) (9 p.).
Shi, Yang, Van Der Meel, Roy, Theek, Benjamin, Oude Blenke, Erik, Pieters, Ebel H E, Fens, Marcel H A M, Ehling, Josef, Schiffelers, Raymond M., Storm, Gert, Van Nostrum, Cornelus F., Lammers, Twan & Hennink, Wim E. (28.04.2015). Complete regression of xenograft tumors upon targeted delivery of paclitaxel via ∏ - ∏ stacking stabilized polymeric micelles. ACS Nano, 9 (4), (pp. 3740-3752) (13 p.).
Talelli, Marina, Barz, Matthias, Rijcken, Cristianne J F, Kiessling, Fabian, Hennink, Wim E. & Lammers, Twan (01.02.2015). Core-crosslinked polymeric micelles - Principles, preparation, biomedical applications and clinical translation. Nano Today, 10 (1), (pp. 93-117) (25 p.).
Vanparijs, N., Maji, S., Louage, B., Voorhaar, L., Laplace, D., Shi, Y., Hennink, W. E., Hoogenboom, R. & De Geest, B. G. (21.08.2015). Correction: Polymer-protein conjugation via a 'grafting to' approach-a comparative study of the performance of protein-reactive RAFT chain transfer agents (Polymer Chemistry(2015) DOI: 10.1039/c4py01224k). Polymer Chemistry, 6 (31), (pp. 5798) (1 p.).
Novo, Luís, Mastrobattista, Enrico, Van Nostrum, Cornelus F., Lammers, Twan & Hennink, Wim E. (01.01.2015). Decationized polyplexes for gene delivery. Expert Opinion on Drug Delivery, 12 (4), (pp. 507-512) (6 p.).
Louage, Benoit, Vanparijs, Nane, Vande Casteele, Sofie R F, Hennink, Wim E. & Van Bocxlaer, Jan F P (12.01.2015). Degradable Ketal-based block copolymer nanoparticles for anticancer drug delivery: A systematic evaluation. Biomacromolecules, 16 (1), (pp. 336-350) (15 p.).
Shi, Yang, Kunjachan, Sijumon, Wu, Zhuojun, Gremse, Felix, Moeckel, Diana, Van Zandvoort, Marc, Kiessling, Fabian, Storm, G, Van Nostrum, Cornelus F., Hennink, Wim E. & Lammers, Twan (01.04.2015). Fluorophore labeling of core-crosslinked polymeric micelles for multimodal in vivo and ex vivo optical imaging. Nanomedicine, 10 (7), (pp. 1111-1125) (15 p.).
Ramazani, F., Chen, W., Van Nostrum, C. F., Storm, G., Kiessling, F., Lammers, T., Hennink, W. E. & Kok, R. J. (30.03.2015). Formulation and characterization of microspheres loaded with imatinib for sustained delivery. International Journal of Pharmaceutics, 482 (1-2), (pp. 123-130) (8 p.).
Oerlemans, Chris, Seevinck, Peter R., Smits, Maarten L., Hennink, Wim E., Bakker, Chris J G, Van Den Bosch, Maurice A A J & Nijsen, J. Frank W (30.03.2015). Holmium-lipiodol-alginate microspheres for fluoroscopy-guided embolotherapy and multimodality imaging. International Journal of Pharmaceutics, 482 (1-2), (pp. 47-53) (7 p.).
Naksuriya, Ornchuma, Shi, Yang, Van Nostrum, Cornelus F., Anuchapreeda, Songyot, Hennink, Wim E. & Okonogi, Siriporn (18.07.2015). HPMA-based polymeric micelles for curcumin solubilization and inhibition of cancer cell growth. European Journal of Pharmaceutics and Biopharmaceutics, 94, (pp. 501-512) (12 p.).
Shirangi, Mehrnoosh, Hennink, Wim E., Somsen, Govert W. & Van Nostrum, Cornelus F. (02.04.2015). Identification and Assessment of Octreotide Acylation in Polyester Microspheres by LC-MS/MS. Pharmaceutical Research, 32 (9), (pp. 3044-3054) (11 p.).
Shi, Yang, Van Nostrum, Cornelus F. & Hennink, Wim E. (14.12.2015). Interfacially Hydrazone Cross-linked Thermosensitive Polymeric Micelles for Acid-Triggered Release of Paclitaxel. ACS Biomaterials Science and Engineering, 1 (6), (pp. 393-404) (12 p.).
Shirangi, Mehrnoosh, Sastre Toraño, Javier, Sellergren, Börje, Hennink, Wim E., Somsen, Govert W. & Van Nostrum, Cornelus F. (21.01.2015). Methyleneation of peptides by N, N, N, N -tetramethylethylenediamine (TEMED) under conditions used for free radical polymerization - A mechanistic study. Bioconjugate Chemistry, 26 (1), (pp. 90-100) (11 p.).
Rahimian, Sima, Kleinovink, Jan Willem, Fransen, Marieke F., Mezzanotte, Laura, Gold, Henrik, Wisse, Patrick, Overkleeft, Hermen, Amidi, Maryam, Jiskoot, Wim, Lo¨wik, Clemens W., Ossendorp, Ferry & Hennink, Wim E. (2015). Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine - In vivo tracking and evaluation of antigen-specific CD8+ T cell immune response. Biomaterials, 37, (pp. 469-477) (9 p.).
Rahimian, Sima, Fransen, Marieke F., Kleinovink, Jan Willem, Amidi, Maryam, Ossendorp, Ferry & Hennink, Wim E. (01.09.2015). Particulate systems based on poly(Lactic-co-glycolic)acid (pLGA) for immunotherapy of cancer. Current Pharmaceutical Design, 21 (29), (pp. 4201-4216) (16 p.).
Chen, Weiluan, Habraken, Tom C J, Hennink, Wim E. & Kok, Robbert J. (15.07.2015). Polymer-Free Drug-Eluting Stents - An Overview of Coating Strategies and Comparison with Polymer-Coated Drug-Eluting Stents. Bioconjugate Chemistry, 26 (7), (pp. 1277-1288) (12 p.).
Rahimian, Sima, Fransen, Marieke F., Kleinovink, Jan Willem, Amidi, Maryam, Ossendorp, Ferry & Hennink, Wim E. (01.08.2015). Polymeric microparticles for sustained and local delivery of antiCD40 and antiCTLA-4 in immunotherapy of cancer. Biomaterials, 61, (pp. 33-40) (8 p.).
Rahimian, Sima, Fransen, Marieke F., Kleinovink, Jan Willem, Christensen, Jonatan Riis, Amidi, Maryam, Hennink, Wim E. & Ossendorp, Ferry (10.04.2015). Polymeric nanoparticles for co-delivery of synthetic long peptide antigen and poly IC as therapeutic cancer vaccine formulation. Journal of Controlled Release, 203, (pp. 16-22) (7 p.).
Vanparijs, N., Maji, S., Louage, B., Voorhaar, L., Laplace, D., Shi, Y., Hennink, W. E., Hoogenboom, R. & De Geest, B. G. (21.08.2015). Polymer-protein conjugation via a 'grafting to' approach-a comparative study of the performance of protein-reactive RAFT chain transfer agents. Polymer Chemistry, 6 (31), (pp. 5602-5614) (13 p.).
Li, Dandan, Kordalivand, Neda, Fransen, Marieke F., Ossendorp, Ferry, Raemdonck, Koen, Vermonden, Tina, Hennink, Wim E. & Van Nostrum, Cornelus F. (01.05.2015). Reduction-sensitive dextran nanogels aimed for intracellular delivery of antigens. Advanced Functional Materials, 25 (20), (pp. 2993-3003) (11 p.).
Kazazi-Hyseni, F., Van Vuuren, S. H., Van Der Giezen, D. M., Pieters, E. H., Ramazani, F., Rodriguez, S., Veldhuis, G. J., Goldschmeding, R., Van Nostrum, C. F., Hennink, W. E. & Kok, R. J. (01.08.2015). Release and pharmacokinetics of near-infrared labeled albumin from monodisperse poly(D,L-lactic-co-hydroxymethyl glycolic acid) microspheres after subcapsular renal injection. Acta Biomaterialia, 22, (pp. 141-154) (14 p.).
Ramazani, F., Hiemstra, C., Steendam, R., Kazazi-Hyseni, F., Van Nostrum, C. F., Storm, G., Kiessling, F., Lammers, T., Hennink, W. E. & Kok, R. J. (01.09.2015). Sunitinib microspheres based on [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers for ocular drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 95, (pp. 368-377) (10 p.).
Petit, Audrey, Redout, Everaldo M, van de Lest, Chris H, de Grauw, Janny C, Müller, Benno, Meyboom, Ronald, van Midwoud, Paul, Vermonden, Tina, Hennink, Wim E & van Weeren, René (2015). Sustained intra-articular release of celecoxib from in situ forming gels made of acetyl-capped PCLA-PEG-PCLA triblock copolymers in horses. Biomaterials, 53, (pp. 426-436) (11 p.). Copyright © 2015 Elsevier Ltd. All rights reserved..
Novo, Luís, Takeda, Kaori M., Petteta, Tamara, Dakwar, George R., Van Den Dikkenberg, Joep B., Remaut, Katrien, Braeckmans, Kevin, Van Nostrum, Cornelus F., Mastrobattista, Enrico & Hennink, Wim E. (05.01.2015). Targeted decationized polyplexes for siRNA delivery. Molecular Pharmaceutics, 12 (1), (pp. 150-161) (12 p.).
Radmalekshahi, Mazda, Visscher, Koen M., Garcia Lopes Maia Rodrigues, João, De Vries, Renko, Hennink, Wim E., Baldus, Marc, Bonvin, Alexandre M J J, Mastrobattista, Enrico & Weingarth, Markus (24.06.2015). The Supramolecular Organization of a Peptide-Based Nanocarrier at High Molecular Detail. Journal of the American Chemical Society, 137 (24), (pp. 7775-7784) (10 p.).
Boere, Kristel W M, Van Den Dikkenberg, Joep, Gao, Yuan, Visser, Jetze, Hennink, Wim E. & Vermonden, Tina (14.09.2015). Thermogelling and chemoselectively cross-linked hydrogels with controlled mechanical properties and degradation behavior. Biomacromolecules, 16 (9), (pp. 2840-2851) (12 p.).
  2014 - Scholarly publications
Hennink, Wim E. & Engbersen, Johan F J (10.12.2014). 13th European symposium on controlled drug delivery (ESCDD2014). Journal of Controlled Release, 195.
Kazazi-Hyseni, Filis, Landin, Mariana, Lathuile, Audrey, Veldhuis, Gert J., Rahimian, Sima, Hennink, Wim E., Kok, Robbert Jan & van Nostrum, Cornelus F. (14.05.2014). Computer Modeling Assisted Design of Monodisperse PLGA Microspheres with Controlled Porosity Affords Zero Order Release of an Encapsulated Macromolecule for 3 Months. Pharmaceutical Research, 31 (10), (pp. 2844-2856).
Boere, Kristel W M, Visser, Jetze, Seyednejad, Hajar, Rahimian, Sima, Gawlitta, Debby, Van Steenbergen, Mies J., Dhert, Wouter J A, Hennink, Wim E., Vermonden, Tina & Malda, Jos (2014). Covalent attachment of a three-dimensionally printed thermoplast to a gelatin hydrogel for mechanically enhanced cartilage constructs. Acta Biomaterialia, 10 (6), (pp. 2602-2611) (10 p.). Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved..
Naksuriya, Ornchuma, Okonogi, Siriporn, Schiffelers, Raymond M. & Hennink, Wim E. (01.03.2014). Curcumin nanoformulations - A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. Biomaterials, 35 (10), (pp. 3365-3383) (19 p.).
Novo, Luís, Rizzo, Larissa Y., Golombek, Susanne K., Dakwar, George R., Lou, Bo, Remaut, Katrien, Mastrobattista, Enrico, Van Nostrum, Cornelus F., Jahnen-Dechent, Wilhelm, Kiessling, Fabian, Braeckmans, Kevin, Lammers, Twan & Hennink, Wim E. (10.12.2014). Decationized polyplexes as stable and safe carrier systems for improved biodistribution in systemic gene therapy. Journal of Controlled Release, 195, (pp. 162-175) (14 p.).
Fransen, Marieke F., Cordfunke, Robert A., Sluijter, Marjolein, Van Steenbergen, Mies J., Drijfhout, Jan W., Ossendorp, Ferry, Hennink, Wim E. & Melief, Cornelis J M (26.03.2014). Effectiveness of slow-release systems in CD40 agonistic antibody immunotherapy of cancer. Vaccine, 32 (15), (pp. 1654-1660) (7 p.).
Buwalda, Sytze J., Boere, Kristel W M, Dijkstra, Pieter J., Feijen, Jan, Vermonden, Tina & Hennink, Wim E. (28.09.2014). Hydrogels in a historical perspective - From simple networks to smart materials. Journal of Controlled Release, 190, (pp. 254-273) (20 p.).
López-Noriega, Adolfo, Hastings, Conn L., Ozbakir, Burcin, O'Donnell, Kathleen E., O'Brien, Fergal J., Storm, G, Hennink, Wim E., Duffy, Garry P. & Ruiz-Hernández, Eduardo (01.01.2014). Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy. Advanced healthcare materials, 3 (6), (pp. 854-859) (6 p.).
Kormelink, Tom Groot, Powe, Desmond G., Kuijpers, Sylvia A., Abudukelimu, Abulikemu, Fens, Marcel H A M, Pieters, Ebel H E, Kassing-Van der Ven, Willemiek W., Habashy, Hany O., Ellis, Ian O., Blokhuis, Bart R., Thio, Marco, Hennink, Wim E., Storm, Gert, Redegeld, Frank A. & Schiffelers, Raymond M. (01.01.2014). Immunoglobulin free light chains are biomarkers of poor prognosis in basal-like breast cancer and are potential targets in tumor-associated inflammation. Oncotarget, 5 (10), (pp. 3159-3167) (9 p.).
MacKay, J. Andrew, Almutairi, Adah, Hoffman, Allan S. & Hennink, Wilhelmus (10.10.2014). NanoDDS 2013 - The 11th international nano drug delivery symposium. Journal of Controlled Release, 191, (pp. 1-3) (3 p.).
Quan, Lingdong, Zhang, Yijia, Crielaard, Bart J., Dusad, Anand, Lele, Subodh M., Rijcken, Cristianne J F, Metselaar, Josbert M., Kostková, Hana, Etrych, Tomáš, Ulbrich, Karel, Kiessling, Fabian, Mikuls, Ted R., Hennink, Wim E., Storm, Gert, Lammers, Twan & Wang, Dong (28.01.2014). Nanomedicines for inflammatory arthritis - Head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes. ACS Nano, 8 (1), (pp. 458-466) (9 p.).
Samadi, Neda, van Steenbergen, Mies J., van den Dikkenberg, Joep B., Vermonden, Tina, van Nostrum, Cornelus F., Amidi, Maryam & Hennink, Wim E. (2014). Nanoparticles Based on a Hydrophilic Polyester with a Sheddable PEG Coating for Protein Delivery. Pharmaceutical Research, 31 (10), (pp. 2593-2604) (12 p.).
Rad-Malekshahi, Mazda, Flement, Matthias, Hennink, Wim E. & Mastrobattista, Enrico (31.12.2014). Optimization of the recombinant production and purification of a self-assembling peptide in Escherichia coli. Microbial Cell Factories, 13 (1).
Kunjachan, Sijumon, Pola, Robert, Gremse, Felix, Theek, Benjamin, Ehling, Josef, Moeckel, Diana, Hermanns-Sachweh, Benita, Pechar, Michal, Ulbrich, Karel, Hennink, Wim E., Storm, Gert, Lederle, Wiltrud, Kiessling, Fabian & Lammers, Twan (12.02.2014). Passive versus active tumor targeting using RGD- and NGR-modified polymeric nanomedicines. Nano Letters, 14 (2), (pp. 972-981) (10 p.).
Ruiz-Hernández, Eduardo, Hess, Michael, Melen, Gustavo J., Theek, Benjamin, Talelli, Marina, Shi, Yang, Ozbakir, Burcin, Teunissen, Erik A., Ramírez, Manuel, Moeckel, Diana, Kiessling, Fabian, Storm, Gert, Scheeren, Hans W., Hennink, Wim E., Szalay, Aladar A., Stritzker, Jochen & Lammers, Twan (07.03.2014). PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses. Polymer Chemistry, 5 (5), (pp. 1674-1681) (8 p.).
Khazaie, Yahya, Novo, Luis, van Gaal, Ethlinn, Fassihi, Afshin, Mirahmadi-Zareh, Seyedeh Zohreh, Esfahani, Mohammad Hossein Nasr, van Nostrum, Cornelus F., Hennink, Wim E. & Dorkoosh, Farid (2014). Poly[N-(2-aminoethyl)ethyleneimine] as a New Non-Viral Gene Delivery Carrier - The Effect of Two Protonatable Nitrogens in the Monomer Unit on Gene Delivery Efficiency. Journal of Pharmacy and Pharmaceutical Sciences, 17 (4), (pp. 461-474) (14 p.).
Petit, Audrey, Sandker, Marjan, Müller, Benno, Meyboom, Ronald, van Midwoud, Paul, Bruin, Peter, Redout, Everaldo M, Versluijs-Helder, Marjan, van der Lest, Chris H A, Buwalda, Sytze J, de Leede, Leo G J, Vermonden, Tina, Kok, Robbert Jan, Weinans, Harrie & Hennink, Wim E (2014). Release behavior and intra-articular biocompatibility of celecoxib-loaded acetyl-capped PCLA-PEG-PCLA thermogels. Biomaterials, 35 (27), (pp. 7919-7928) (10 p.). Copyright © 2014 Elsevier Ltd. All rights reserved..
Novo, Luiìs, Mastrobattista, Enrico, Van Nostrum, Cornelus F. & Hennink, Wim E. (16.04.2014). Targeted decationized polyplexes for cell specific gene delivery. Bioconjugate Chemistry, 25 (4), (pp. 802-812) (11 p.).
Heukers, Raimond, Altintas, Isil, Raghoenath, Smiriti, De Zan, Erica, Pepermans, Richard, Roovers, Rob C., Haselberg, Rob, Hennink, Wim E., Schiffelers, Raymond M., Kok, Robbert J. & Van Bergen en Henegouwen, Paul M P (01.01.2014). Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles. Biomaterials, 35 (1), (pp. 601-610) (10 p.).
López-Noriega, Adolfo, Ruiz-Hernández, Eduardo, Quinlan, Elaine, Storm, Gert, Hennink, Wim E. & O'Brien, Fergal J. (10.08.2014). Thermally triggered release of a pro-osteogenic peptide from a functionalized collagen-based scaffold using thermosensitive liposomes. Journal of Controlled Release, 187, (pp. 158-166) (9 p.).
Boere, Kristel W M, Soliman, Bram G., Rijkers, Dirk T S, Hennink, Wim E. & Vermonden, Tina (08.04.2014). Thermoresponsive Injectable Hydrogels Cross-Linked by Native Chemical Ligation. Macromolecules, 47 (7), (pp. 2430-2438) (9 p.).
Van Elk, Merel, Deckers, Roel, Oerlemans, Chris, Shi, Yang, Storm, Gert, Vermonden, Tina & Hennink, Wim E. (10.03.2014). Triggered release of doxorubicin from temperature-sensitive poly(N-(2-hydroxypropyl)-methacrylamide mono/dilactate) grafted liposomes. Biomacromolecules, 15 (3), (pp. 1002-1009) (8 p.).
Shi, Yang, Elkhabaz, Ahmed, Yousef Yengej, Fjodor A., van den Dikkenberg, Joep, Hennink, Wim E. & van Nostrum, Cornelus F. (01.01.2014). π-π Stacking Induced Enhanced Molecular Solubilization, Singlet Oxygen Production, and Retention of a Photosensitizer Loaded in Thermosensitive Polymeric Micelles. Advanced healthcare materials, 3 (12), (pp. 2023-2031) (9 p.).
  2013 - Scholarly publications
van Noort, J.M., Bsibsi, M., Nacken, P.J., Gerritsen, W.H., Amor, S., Holtman, I.R., Boddeke, E., van Ark, I., Leusink-Muis, A., Folkerts, G., Hennink, W.E. & Amidi, M. (2013). Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles. Biomaterials, 34 (3), (pp. 831-40) (10 p.).
Oerlemans, C., Seevinck, P.R., van de Maat, G.H., Boulkhrif, H., Bakker, C.J.G., Hennink, W.E. & Nijsen, J.F.W (2013). Alginate-lanthanide microspheres for MRI-guided embolotherapy. Acta Biomaterialia, 9 (1), (pp. 4681-4687) (7 p.).
Novo, L., van Gaal, E.V.B., Mastrobattista, E., van Nostrum, C.F. & Hennink, W.E. (2013). Decationized crosslinked polyplexes for redox-triggered gene delivery. Journal of Controlled Release, 169 (3), (pp. 246-56) (11 p.).
Petit, A., Muller, B., Meijboom, R., Bruin, P., van de Manakker, F., Versluijs-Helder, M., de Leede, L.G., Doornbos, A., Landin, M., Hennink, W.E. & Vermonden, T. (2013). Effect of polymer composition on rheological and degradation properties of temperature-responsive gelling systems composed of acyl-capped PCLA-PEG-PCLA. Biomacromolecules, 14 (9), (pp. 3172-82) (11 p.).
Oerlemans, C., Deckers, R.H.R., Storm, G., Hennink, W.E. & Nijsen, J.F.W (2013). Evidence for a new mechanism behind HIFU-triggered release from liposomes. Journal of Controlled Release, 168 (3), (pp. 327-33) (7 p.).
Sandker, M.J., Petit, A., Redout, E., Siebelt, M, Müller, B., Bruin, P., Meyboom, R., Vermonden, T., Hennink, W.E. & Weinans, H.H. (2013). In situ forming acyl-capped PCLA-PEG-PCLA triblock copolymer based hydrogels. Biomaterials, 34 (32), (pp. 8002-8011) (10 p.).
Rizzo, L.Y., Golombek, S.K., Mertens, M.E., Pan, Y., Laaf, D., Broda, J., Jayapaul, J., Mockel, D., Subr, V., Hennink, W.E., Storm, G., Simon, U., Jahnen-Dechent, W., Kiessling, F. & Lammers, T. (2013). In Vivo Nanotoxicity Testing using the Zebrafish Embryo Assay. J Mater Chem B Mater Biol Med, 1, (pp. 3918-3925) (8 p.).
van der Meel, Roy, Oliveira, Sabrina, Altintas, Isil, Heukers, Raimond, Pieters, Ebel H E, van Bergen en Henegouwen, Paul M P, Storm, G, Hennink, Wim, Kok, Robbert J & Schiffelers, Raymond M (26.07.2013). Inhibition of tumor growth by targeted anti-EGFR/IGF-1R nanobullets depends on efficient blocking of cell survival pathways. Molecular Pharmaceutics, 10 (10), (pp. 3717-27) (11 p.).
Matricardi, P., Di Meo, C., Coviello, T., Hennink, W.E. & Alhaique, F. (2013). Interpenetrating Polymer Networks polysaccharide hydrogels for drug delivery and tissue engineering. Advanced Drug Delivery Reviews, 65 (9), (pp. 1172-87) (16 p.).
Bult, W., Kroeze, S.G.C., Elschot, M., Seevinck, P.R., Beekman, F.J., de Jong, H.W.A.M., Uges, D.R.A., Kosterink, J.G.W., Luijten, P.R., Hennink, W.E., van het Schip, A.D., Bosch, J.L.H.R., Nijsen, J.F.W & Jans, J.J.M. (2013). Intratumoral administration of holmium-166 acetylacetonate microspheres: antitumor efficacy and feasibility of multimodality imaging in renal cancer. PLoS One, 8 (1), (pp. e52178) (1 p.).
Talelli, Marina, Oliveira, Sabrina, Rijcken, Cristianne, Pieters, Ebel H E, Etrych, Tomas, Ulbrich, Karel, van Nostrum, Rene C F, Storm, G, Hennink, Wim E & Lammers, Twan (2013). Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy. Biomaterials, 34 (4), (pp. 1255-60) (6 p.). Copyright © 2012 Elsevier Ltd. All rights reserved..
Talelli, M., Oliveira, S., Rijcken, C.J.F., Pieters, E.H.E., Etrych, T., Ulbrich, K., van Nostrum, R.C., Storm, G., Hennink, W.E. & Lammers, T. (2013). Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy. Biomaterials, 34 (4), (pp. 1255-60) (6 p.).
Knezevi, N.Z., Ruiz-Hernandez, E., Hennink, W.E. & Vallet-Regi, M. (2013). Magnetic mesoporous silica-based core/shell nanoparticles for biomedical applications. RSC Advances, 3, (pp. 9584-9593) (10 p.).
Samadi, N., van Nostrum, C.F., Vermonden, T., Amidi, M. & Hennink, W.E. (2013). Mechanistic studies on the degradation and protein release characteristics of poly(lactic-co-glycolic-co-hydroxymethylglycolic acid) nanospheres. Biomacromolecules, 14 (4), (pp. 1044-53) (10 p.).
Altintas, I., Heukers, R., van der Meel, R., Lacombe, M., Amidi, M., van Bergen en Henegouwen, P.M.P., Hennink, W.E., Schiffelers, R.M. & Kok, R.J. (2013). Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells. Journal of Controlled Release, 165 (2), (pp. 110-118) (9 p.).
Deckers, R.H.R., Paradissis, A., Oerlemans, C., Talelli, M.A., Storm, G., Hennink, W.E. & Nijsen, J.F.W (2013). New insights into the HIFU-triggered release from polymeric micelles. Langmuir, 29 (30), (pp. 9483-9490) (8 p.).
Cherng, J.Y., Hou, T.Y., Shih, M.F., Talsma, H. & Hennink, W.E. (2013). Polyurethane-based drug delivery systems. International Journal of Pharmaceutics, 450 (1-2), (pp. 145-62) (18 p.).
Liu, J., Xu, Y., Yang, Q., Li, C., Hennink, W.E., Zhuo, R. & Jiang, X. (2013). Reduction biodegradable brushed PDMAEMA derivatives synthesized by atom transfer radical polymerization and click chemistry for gene delivery. Acta Biomaterialia, 9 (8), (pp. 7758-66) (9 p.).
Shi, Y., van den Dungen, E.T.A., Klumperman, B., van Nostrum, C.F. & Hennink, W.E. (2013). Reversible addition−fragmentation chain transfer synthesis of a micelle-forming, structure reversible thermosensitive diblock copolymer based on the N‑(2-hydroxy propyl)methacrylamide backbone. ACS Macro Letters, 2, (pp. 403-408) (6 p.).
Samadi, N., Abbadessa, A., Di Stefano, A., Van Nostrum, C.F., Vermonden, T., Rahimian, S., Teunissen, E.A., Van Steenbergen, M.J., Amidi, M. & Hennink, W.E. (29.12.2013). The effect of lauryl capping group on protein release and degradation of poly(d,l-lactic-co-glycolic acid) particles. Journal of Controlled Release, 172 (2), (pp. 436-443) (8 p.).
Samadi, N., Abbadessa, A., Di Stefano, A., van Nostrum, C.F., Vermonden, T., Rahimian, S., Teunissen, E.A., van Steenbergen, M.J., Amidi, M. & Hennink, W.E. (2013). The effect of lauryl capping group on protein release and degradation of poly(d,l-lactic-co-glycolic acid) particles. Journal of Controlled Release, 172 (2), (pp. 436-43) (8 p.).
Schellekens, Huub, Hennink, Wim E & Brinks, Vera (2013). The immunogenicity of polyethylene glycol - facts and fiction. Pharmaceutical Research, 30 (7), (pp. 1729-34) (6 p.).
Shi, Y., van Steenbergen, M.J., Teunissen, E.A., Novo, L., Gradmann, S., Baldus, M., van Nostrum, C.F. & Hennink, W.E. (2013). Π−Π Stacking increases the stability and loading capacity of thermosensitive polymeric micelles for chemotherapeutic drugs. Biomacromolecules, 14 (6), (pp. 1826-1837) (12 p.).
  2012 - Scholarly publications
de Graaf, A.J., Azevedo Próspero dos Santos, I.I., Pieters, E.H.E., Rijkers, D.T.S., van Nostrum, C.F., Vermonden, T., Kok, R.J., Hennink, W.E. & Mastrobattista, E. (2012). A micelle-shedding thermosensitive hydrogel as sustained release formulation. Journal of Controlled Release, 162, (pp. 582-590) (9 p.).
Shau, M.D., Shih, M.F., Lin, C.C., Chuang, I.C., Hung, W.C., Hennink, W.E. & Cherng, J.Y. (2012). A one-step process in preparation of cationic nanoparticles with poly(lactide-co-glycolide)-containing polyethylenimine gives efficient gene delivery. European Journal of Pharmaceutical Sciences, 46 (5), (pp. 522-9) (8 p.).
Verheul, R.J., Hagenaars, N., van Es, T., van Gaal, E.V.B., de Jong, P.H.J.L.F, Bruijns, S., Mastrobattista, E., Slutter, B., Que, I., Heldens, J.G., van den Bosch, H., Glansbeek, H.L., Hennink, W.E. & Jiskoot, W. (2012). A step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccine. European Journal of Pharmaceutical Sciences, 45 (4), (pp. 467-74) (8 p.).
Coimbra, M., Rijcken, C.J.F., Stigter, M., Hennink, W.E., Storm, G. & Schiffelers, R.M. (2012). Antitumor efficacy of dexamethasone-loaded core-crosslinked polymeric micelles. Journal of Controlled Release, 163 (3), (pp. 361-7) (7 p.).
van Rooy, I., Hennink, W.E., Storm, G., Schiffelers, R.M. & Mastrobattista, E. (2012). Attaching the phage display-selected GLA peptide to liposomes: factors influencing target binding. European Journal of Pharmaceutical Sciences, 45 (3), (pp. 330-5) (6 p.).
Ji, W., Yang, F., Seyednejad, S.H., Chen, Z., Hennink, W.E., Anderson, J.M., van den Beucken, J.J. & Jansen, J.A. (2012). Biocompatibility and degradation characteristics of PLGA-based electrospun nanofibrous scaffolds with nanoapatite incorporation. Biomaterials, 33 (28), (pp. 6604-14) (11 p.).
Seyednejad, H., Ji, W., Yang, F., van Nostrum, C.F., Vermonden, T., van den Beucken, J.J., Dhert, W.J.A., Hennink, W.E. & Jansen, J.A. (2012). Coaxially Electrospun Scaffolds Based on Hydroxyl-Functionalized Poly(epsilon-caprolactone) and Loaded with VEGF for Tissue Engineering Applications. Biomacromolecules, 13 (11), (pp. 3650-3660) (11 p.).
Ghassemi, Amir H., Van Steenbergen, Mies J., Barendregt, Arjan, Talsma, Herre, Kok, Robbert J., Van Nostrum, Cornelus F., Crommelin, Daan J. A. & Hennink, Wim E. (01.01.2012). Controlled release of octreotide and assessment of peptide acylation from poly(D,L-lactide-co-hydroxymethyl glycolide) compared to PLGA microspheres. Pharmaceutical Research, 29 (1), (pp. 110-120) (11 p.).
Khonkarn, R., Mankhetkorn, S., Talelli, M., Hennink, W.E. & Okonogi, S. (2012). Cytostatic effect of xanthone-loaded mPEG-b-p(HPMAm-Lac2) micelles towards doxorubicin sensitive and resistant cancer cells. Colloids and Surfaces B: Biointerfaces, 94, (pp. 266-73) (8 p.).
Dolman, Emmy, van Dorenmalen, Kim M.A., Pieters, Ebel H.E., Sparidans, Rolf W., Lacombe, Marie, Szokol, Bálint, Orfi, László, Kéri, György, Bovenschen, Niels, Storm, Gert, Hennink, Wim E. & Kok, Robbert J. (01.01.2012). Dendrimer-based macromolecular conjugate for the kidney-directed delivery of a multitargeted sunitinib analogue. Macromolecular Bioscience, 12 (1), (pp. 93-103) (11 p.).
Dolman, M.E.M., van Dorenmalen, K.M.A., Pieters, E.H.E., Sparidans, R.W., Lacombe, M., Szokol, B., Örfi, L., Kéri, G., Bovenschen, N., Storm, G., Hennink, W.E. & Kok, R.J. (2012). Dendrimer-Based Macromolecular Conjugate for the Kidney-Directed Delivery of a Multitargeted Sunitinib Analoguw. Macromolecular Bioscience, 12 (1), (pp. 93-103) (11 p.).
Lammers, T., Kiessling, F., Hennink, W.E. & Storm, G. (2012). Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. Journal of Controlled Release, 161 (2), (pp. 175-87) (13 p.).
Jiang, X., Li, L., Liu, J., Hennink, W.E. & Zhuo, R. (2012). Facile fabrication of thermo-responsive and reduction-sensitive polymeric micelles for anticancer drug delivery. Macromolecular Bioscience, 12 (5), (pp. 703-11) (9 p.).
Crielaard, B.J., Rijcken, C.J.F., Quan, L., van der Wal, S., Altintas, I., van der Pot, M., Kruijtzer, J.A.W., Liskamp, R.M.J., Schiffelers, R.M., van Nostrum, C.F., Hennink, W.E., Wang, D., Lammers, T.G.G.M. & Storm, G. (2012). Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angewandte Chemie-International Edition, 29, (pp. 7254-7258) (5 p.).
Censi, R., di Martino, P., Vermonden, T. & Hennink, W.E. (2012). Hydrogels for protein delivery in tissue engineering. Journal of Controlled Release, 161 (2), (pp. 680-92) (13 p.).
Vermonden, T., Censi, R. & Hennink, W.E. (2012). Hydrogels for protein delivery. Chemical Reviews, 112 (5), (pp. 2853-88) (36 p.).
Dolman, M.E.M., van Dorenmalen, K.M.A., Pieters, E.H.E., Lacombe, M., Pato, J., Storm, G., Hennink, W.E. & Kok, R.J. (2012). Imatinib-ULS-lysozyme: a proximal tubular cell-targeted conjugate of imatinib for the treatment of renal diseases. Journal of Controlled Release, 157 (3), (pp. 461-8) (8 p.).
Seyednejad, S.H., Gawlitta, D., Kuiper, R.V., de Bruin, A., van Nostrum, C.F., Vermonden, T., Dhert, W.J.A. & Hennink, W.E. (2012). In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly(epsilon-caprolactone). Biomaterials, 33 (17), (pp. 4309-4318) (10 p.).
Crielaard, B.J., van der Wal, S., Le, H.T., Bode, A.T., Lammers, T., Hennink, W.E., Schiffelers, R.M., Fens, M.H.A.M. & Storm, G. (2012). Liposomes as carriers for colchicine-derived prodrugs: vascular disrupting nanomedicines with tailorable drug release kinetics. European Journal of Pharmaceutical Sciences, 45 (4), (pp. 429-35) (7 p.).
Pescosolido, L., Feruglio, L., Farra, R., Fiorentino, S., Colombo, I., Coviello, T., Matricardi, P., Hennink, W.E., Vermonden, T. & Grassi, M. (2012). Mesh size distribution determination of interpenetrating polymer networks hydrogels. Soft Matter, 8, (pp. 3708-3715) (8 p.).
Petit, A., Muller, B., Bruin, P., Meyboom, R., Piest, M., Kroon-Batenburg, L.M.J., de Leede, L.G., Hennink, W.E. & Vermonden, T. (2012). Modulating rheological and degradation properties of temperature-responsive gelling systems composed of blends of PCLA-PEG-PCLA triblock copolymers and their fully hexanoyl-capped derivatives. Acta Biomaterialia, 8 (12), (pp. 4260-4267) (8 p.).
Altintas, I., Heukers, R., van der Meel, R., Lacombe, M., Amidi, M., van Bergen en Henegouwen, P.M.P., Hennink, W.E., Schiffelers, R.M. & Kok, R.J. (2012). Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells. Cell Biology International, 165 (2), (pp. 110-118) (9 p.).
Mastrobattista, E. & Hennink, W.E. (2012). Polymers for gene delivery: charged for success. Nature Materials, (pp. 10-12) (3 p.).
Varkouhi, A.K., Mountrichas, G., Schiffelers, R.M., Lammers, T., Storm, G., Pispas, S. & Hennink, W.E. (2012). Polyplexes based on cationic polymers with strong nucleic acid binding properties. European Journal of Pharmaceutical Sciences, 45 (4), (pp. 459-66) (8 p.).
Bult, W., de Leeuw, H., Steinebach, O.M., van der Bom, M.J., Wolterbeek, H.T., Heeren, R.M.A., Bakker, C.J.G., van het Schip, A.D., Hennink, W.E. & Nijsen, J.F.W (2012). Radioactive holmium acetylacetonate microspheres for interstitial microbrachytherapy: an in vitro and in vivo stability study. Pharmaceutical Research, 29 (3), (pp. 827-836) (10 p.).
Dolman, M., Harmsen, Stefan, Pieters, Ebel H E, Sparidans, Rolf W., Lacombe, Marie, Szokol, Bálint, Orfi, László, Kéri, György, Storm, G, Hennink, Wim E. & Kok, Robbert J. (2012). Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells. International Journal of Nanomedicine, 7, (pp. 417-433) (17 p.).
Liu, Y., Ghassemi, A.H., Hennink, W.E. & Schwendeman, S.P. (2012). The microclimate pH in poly(D,L-lactide-co-hydroxymethyl glycolide) microspheres during biodegradation. Biomaterials, 33 (30), (pp. 7584-7593) (10 p.).
de Graaf, A.J., Mastrobattista, E., Vermonden, T., van Nostrum, C.F., Rijkers, D.T.S., Liskamp, R.M.J. & Hennink, W.E. (2012). Thermosensitive peptide-hybrid ABC block copolymers obtained by ATRP: synthesis, self assembly, and enzymatic degradation. Macromolecules, 45, (pp. 842-851) (10 p.).
Van Der Meel, R., Oliveira, S., Altintas, I., Haselberg, R., Roovers, R.C., Van Bergen en Henegouwen, P.M.P., Hennink, W.E., Storm, G, Schiffelers, R.M. & Kok, R.J. (01.11.2012). Tumor-targeted nanobullets for anti-cancer combination therapy. European Journal of Cancer, 48, (pp. 38) (1 p.).
van der Meel, R., Oliveira, S., Altintas, I., Haselberg, R., van der Veeken, J., Roovers, R.C., van Bergen en Henegouwen, P.M.P., Storm, G., Hennink, W.E., Schiffelers, R.M. & Kok, R.J. (2012). Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment. Journal of Controlled Release, 159 (2), (pp. 281-9) (9 p.).
  2011 - Scholarly publications
Crielaard, B.J., van der Wal, S., Lammers, T., Le, H.T., Hennink, W.E., Schiffelers, R.M., Storm, G. & Fens, M.H.A.M. (2011). A polymeric colchicinoid prodrug with reduced toxicity and improved efficacy for vascular disruption in cancer therapy. International Journal of Nanomedicine, 6, (pp. 2697-703) (7 p.).
Censi, R., Schuurman, W., Malda, J., Di Dato, G., Burgisser, P., Dhert, W.J.A., van Nostrum, C.F., Vermonden, T. & Hennink, W.E. (2011). A Printable Photopolymerizable Thermosensitive p(HPMAm-lactate)-PEG Hydrogel for Tissue Engineering. Advanced Functional Materials, 10, (pp. 1833-1842) (10 p.).
Seyednejad, S.H., Ji, W., Schuurman, W., Dhert, W.J.A., Malda, J., Yang, F., Jansen, J.A., van Nostrum, C.F., Vermonden, T. & Hennink, W.E. (2011). An electrospun degradable scaffold based on a novel hydrophilic polyester for tissue-engineering applications. Macromolecular Bioscience, 11 (12), (pp. 1684-1692) (9 p.).
Schillemans, J.P., Verheyen, E., Barendregt, A., Hennink, W.E. & van Nostrum, C.F. (2011). Anionic and cationic dextran hydrogels for post-loading and release of proteins. Journal of Controlled Release, 150, (pp. 266-271) (6 p.).
Amidi, M., de Raad, M., Crommelin, D.J.A., Hennink, W.E. & Mastrobattista, E. (2011). Antigen-expressing immunostimulatory liposomes as a genetically programmable synthetic vaccine. Systems and Synthetic Biology, 5 (1-2), (pp. 21-31) (11 p.).
de Graaf, A.J., Mastrobattista, E., van Nostrum, C.F., Rijkers, D.T.S., Hennink, W.E. & Vermonden, T. (2011). ATRP, subsequent azide substitution and "click" chemistry: three reactions using one catalyst in a one-pot. Chemical Communications, 47, (pp. 6972-6974) (3 p.).
Pescosolido, L., Piro, T., Vermonden, T., Coviello, T., Alhaique, F., Hennink, W.E. & Matricardi, P. (2011). Biodegradable IPNs based on oxidized alginate and dextran-HEMA for controlled release of proteins. Carbohydrate Polymers, 86, (pp. 208-213) (6 p.).
D'Aurizio, E., Sozio, P., Cerasa, L.S., Vacca, M., Brunetti, L., Orlando, G., Chiavaroli, A., Kok, R.J., Hennink, W.E. & Di Stefano, A. (2011). Biodegradable microspheres loaded with an antiparkinson prodrug: an in vivo pharmacokinetic study. Molecular Pharmaceutics, 8, (pp. 2408-2415) (8 p.).
Verheyen, E., Schillemans, J.P., van Wijk, M., Demeniex, M.A., Hennink, W.E. & van Nostrum, C.F. (2011). Challenges for the effective molecular imprinting of proteins. Biomaterials, 32 (11), (pp. 3008-20) (13 p.).
Lee, J.S., Ankone, M., Pieters, E., Schiffelers, R.M., Hennink, W.E. & Feijen, J. (2011). Circulation kinetics and biodistribution of dual-labeled polymersomes with modulated surface charge in tumor-bearing mice: comparison with stealth liposomes. Journal of Controlled Release, 155 (2), (pp. 282-8) (7 p.).
van Rooy, I., Mastrobattista, E., Storm, G., Hennink, W.E. & Schiffelers, R.M. (2011). Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain. Journal of Controlled Release, 150, (pp. 30-36) (7 p.).
Verheul, R.J., Slutter, B., Bal, S.M., Bouwstra, J.A., Jiskoot, W. & Hennink, W.E. (2011). Covalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccination. Journal of Controlled Release, 156 (1), (pp. 46-52) (7 p.).
Harmsen, S,, Dolman, M.E.M., Nemes, Z., Lacombe, M., Szokol, B., Pato, J., Keri, G., Orfi, L., Storm, G., Hennink, W.E. & Kok, R.J. (2011). Development of a cell-selective and intrinsically active multikinase inhibitor bioconjugate. Bioconjugate Chemistry, 22 (4), (pp. 540-5) (6 p.).
van Gaal, E.V.B., Oosting, R.S., van Eijk, R., Bakowska, M., Feyen, D., Kok, R.J., Hennink, W.E., Crommelin, D.J.A. & Mastrobattista, E. (2011). DNA nuclear targeting sequences for non-viral gene delivery. Pharmaceutical Research, 28 (7), (pp. 1707-22) (16 p.).
van Putten, S.M., Wubben, M., Plantinga, J.A., Hennink, W.E., van Luyn, M.J.A. & Harmsen, M.C. (2011). Endotoxin contamination delays the foreign body reaction. Journal of Biomedical Materials Research - Part A, 98 (4), (pp. 527-34) (8 p.).
Chaisri, W., Ghassemi, A.H., Hennink, W.E. & Okonogi, S. (2011). Enhanced gentamicin loading and release of PLGA and PLHMGA microspheres by varying the formulation parameters. Colloids and Surfaces B: Biointerfaces, 84 (2), (pp. 508-14) (7 p.).
Seyednejad, S.H., Ghassemi, A.H., van Nostrum, C.F., Vermonden, T. & Hennink, W.E. (2011). Functional aliphatic polyesters for biomedical and pharmaceutical applications. Journal of Controlled Release, 152 (1), (pp. 168-76) (9 p.).
Varkouhi, A.K., Lammers, T., Schiffelers, R.M., van Steenbergen, M.J., Hennink, W.E. & Storm, G. (2011). Gene silencing activity of siRNA polyplexes based on biodegradable polymers. European Journal of Pharmaceutics and Biopharmaceutics, 77 (3), (pp. 450-7) (8 p.).
van Gaal, E.V.B., van Eijk, R., Oosting, R.S., Kok, R.J., Hennink, W.E., Crommelin, D.J.A. & Mastrobattista, E. (2011). How to screen non-viral gene delivery systems in vitro?. Journal of Controlled Release, 154 (3), (pp. 218-32) (15 p.).
Pescosolido, L., Schuurman, W., Malda, J., Matricardi, P., Alhaigue, F., Coviello, T., van Weeren, P.R., Dhert, W.J.A., Hennink, W.E. & Vermonden, T. (2011). Hyaluronic acid and dextran-based semi-IPN hydrogels as biomaterials for bioprinting. Biomacromolecules, 12 (5), (pp. 1831-1838) (8 p.).
Pescosolido, L., Vermonden, T., Malda, J., Censi, R., Dhert, W.J.A., Alhaique, F., Hennink, W.E. & Matricardi, P. (2011). In situ forming IPN hydrogels of calcium alginate and dextran-HEMA for biomedical applications. Acta Biomaterialia, 7 (4), (pp. 1627-1633) (7 p.).
van Rooy, I., Cakir-Tascioglu, S., Hennink, W.E., Storm, G., Schiffelers, R.M. & Mastrobattista, E. (2011). In vivo methods to study uptake of nanoparticles into the brain. Pharmaceutical Research, 28 (3), (pp. 456-71) (16 p.).
de Graaf, A.J., Boere, K.W.M., Kemmink, J., Fokkink, R.G., van Nostrum, C.F., Rijkers, D.T.S., van de Gucht, J., Wienk, H.L.J., Baldus, M., Mastrobattista, E., Vermonden, T. & Hennink, W.E. (2011). Looped structure of flowerlike Micelles revealed by 1H NMR relaxometry and light scattering. Langmuir, 27 (16), (pp. 9843-9848) (6 p.).
Huis In 't Veld, R., Storm, G., Hennink, W.E., Kiessling, F. & Lammers, T. (2011). Macromolecular nanotheranostics for multimodal anticancer therapy. Nanoscale, 3 (10), (pp. 4022-34) (13 p.).
Talelli, M., Rijcken, J.F., Oliveira, S., Meel, R., van Bergen en Henegouwen, P.M.P., Lammers, T., van Nostrum, C.F., Storm, G. & Hennink, W.E. (2011). Nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting. Journal of Controlled Release, 151 (2), (pp. 183-192) (10 p.).
Fedorovich, N.E., Alblas, J., Hennink, W.E., Öner, F.C. & Dhert, W.J.A. (2011). Organ printing: the future of bone regeneration?. Trends in Biotechnology, 29 (12), (pp. 601-606) (6 p.).
Khonkarn, R., Mankhetkorn, S., Hennink, W.E. & Okonogi, S. (2011). PEG-OCL micelles for quercetin solubilization and inhibition of cancer cell growth. European Journal of Pharmaceutics and Biopharmaceutics, 79 (2), (pp. 268-75) (8 p.).
Seyednejad, S.H., Gawlitta, D., Dhert, W.J.A., van Nostrum, C.F., Vermonden, T. & Hennink, W.E. (2011). Preparation and characterization of a three-dimensional printed scaffold based on a functionalized polyester for bone tissue engineering applications. Acta Biomaterialia, 7 (5), (pp. 1999-2006) (8 p.).
van Rooy, I., Wu, S.Y., Storm, G., Hennink, W.E., Dinter-Heidorn, H., Schiffelers, R.M. & Mastrobattista, E. (2011). Preparation and characterization of liposomal formulations of neurotensin-degrading enzyme inhibitors. International Journal of Pharmaceutics, 416 (2), (pp. 448-52) (5 p.).
D'Aurizio, E., van Nostrum, C.F., van Steenbergen, M.J., Sozio, P., Siepmann, F., Siepmann, J., Hennink, W.E. & Di Stefano, A. (2011). Preparation and characterization of poly(lactic-co-glycolic acid) microspheres loaded with a labile antiparkinson prodrug. International Journal of Pharmaceutics, 409 (1-2), (pp. 289-96) (8 p.).
Verheyen, E., van der Wal, S., Deschout, H., Braeckmans, K., de Smedt, S., Barendregt, A., Hennink, W.E. & van Nostrum, C.F. (2011). Protein macromonomers containing reduction-sensitive linkers for covalent immobilization and glutathione triggered release from dextran hydrogels. Journal of Controlled Release, 156, (pp. 329-336) (8 p.).
Talelli, Marina, Rijcken, Cristianne J F, Santos Oliveira, Sabrina, van der Meel, Roy, van Bergen en Henegouwen, Paul M P, Lammers, Twan, van Nostrum, Cornelus F, Storm, Gert & Hennink, Wim E (15.07.2011). Reprint of "Nanobody--shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting". Journal of Controlled Release, 153 (1), (pp. 93-102) (10 p.). Copyright © 2011 Elsevier B.V. All rights reserved..
de Geest, B.G., de Koker, S.C., Demeester, J., De Smedt, S.C. & Hennink, W.E. (2011). Self-exploding particles. Journal of Polymer Science, Part A: Polymer Chemistry, 1, (pp. 137-148) (12 p.).
Varkouhi, A.K., Foillard, S., Lammers, T., Schiffelers, R.M., Doris, E., Hennink, W.E. & Storm, G. (2011). SiRNA delivery with functionalized carbon nanotubes. International Journal of Pharmaceutics, 416 (2), (pp. 419-25) (7 p.).
Talelli, M.A., Montari, K., Rijcken, C.J.F., Aben, R.W.M., Lammers, T.G.G.M., Scheeren, H.W., van Nostrum, C.F., Storm, G. & Hennink, W.E. (2011). Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry. Bioconjugate Chemistry, 22, (pp. 2519-2530) (12 p.).
Censi, R., van Putten, S., Vermonden, T., di Martino, P., van Nostrum, C.F., Harmsen, M.C., Bank, R.A. & Hennink, W.E. (2011). The tissue response to photopolymerized PEG-p(HPMAm-lactate)-based hydrogels. Journal of Biomedical Materials Research - Part A, 97 (3), (pp. 219-29) (11 p.).
Lammers, T., Aime, S., Hennink, W.E., Storm, G. & Kiessling, F. (2011). Theranostic nanomedicine. Accounts of Chemical Research, 44 (10), (pp. 1029-38) (10 p.).
Talelli, M. & Hennink, W.E. (2011). Thermosensitive polymeric micelles for targeted drug delivery. Nanomedicine, 6 (7), (pp. 1245-1255) (11 p.).
  2010 - Scholarly publications
Chaisri, W., Hennink, W.E., Ampasavate, C. & Okonogi, S. (2010). Cephalexin microspheres for dairy mastitis: effect of preparation method and surfactant type on physicochemical properties of the microspheres. AAPS PharmSciTech, 11 (2), (pp. 945-51) (7 p.).
Chaiyana, W., Saeio, K., Hennink, W.E. & Okonogi, S. (2010). Characterization of potent anticholinesterase plant oil based microemulsion. International Journal of Pharmaceutics, 401 (1-2), (pp. 32-40) (9 p.).
Amidi, M., Mastrobattista, E., Jiskoot, W. & Hennink, W.E. (2010). Chitosan-based delivery systems for protein therapeutics and antigens. Advanced Drug Delivery Reviews, 62 (1), (pp. 59-82) (24 p.).
van Hell, A.J., Klymchenko, A., Burgers, P.P., Moret, E.E., Jiskoot, W., Hennink, W.E., Crommelin, D.J.A. & Mastrobattista, E. (2010). Conformation and intermolecular interactions of SA2 peptides self-assembled into vesicles. Journal of Physical Chemistry B, 114 (34), (pp. 11046-52) (7 p.).
Verheyen, E., Delain-Bioton, L., van der Wal, S., el Morabit, N., Barendregt, A., Hennink, W.E. & van Nostrum, C.F. (2010). Conjugation of methacrylamide groups to a model protein via a reducible linker for immobilization and subsequent triggered release from hydrogels. Macromolecular Bioscience, 10 (12), (pp. 1517-26) (10 p.).
Slutter, B., Soema, P.C., Ding, Z., Verheul, R.J., Hennink, W.E. & Jiskoot, W. (2010). Conjugation of ovalbumin to trimethyl chitosan improves immunogenicity of the antigen. Journal of Controlled Release, 143, (pp. 207-214) (8 p.).
Talelli, M., Iman, M., Varkouhi, A.K., Rijcken, C.J.F., Schiffelers, R.M., Etrych, T., Ulbrich, K., van Nostrum, C.F., Lammers, T., Storm, G. & Hennink, W.E. (2010). Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin. Biomaterials, 31 (30), (pp. 7797-804) (8 p.).
Rijcken, C.J.F., Talelli, M.A., van Nostrum, C.F., Storm, G. & Hennink, W.E. (2010). Crosslinked micelles with transiently linked drugs – a versatile drug delivery system. European Journal of Nanomedicine, 3 (1), (pp. 19-24) (6 p.).
Dolman, M.E.M., Harmsen, S., Storm, G., Hennink, W.E. & Kok, R.J. (30.11.2010). Drug targeting to the kidney: Advances in the active targeting of therapeutics to proximal tubular cells. Advanced Drug Delivery Reviews, 62 (14), (pp. 1344-57) (14 p.).
van Gaal, E.V.B., Spierenburg, G., Hennink, W.E., Crommelin, D.J.A. & Mastrobattista, E. (2010). Flow cytometry for rapid size determination and sorting of nucleic acid containing nanoparticles in biological fluids. Journal of Controlled Release, 141 (3), (pp. 328-38) (11 p.).
Varkouhi, A.K., Verheul, R.J., Schiffelers, R.M., Lammers, T.G.G.M., Storm, G. & Hennink, W.E. (2010). Gene silencing activity of siRNA polyplexes based on thiolated N,N,N-trimethylated chitosan. Bioconjugate Chemistry, 21, (pp. 2339-2346) (8 p.).
Bult, W., Varkevisser, R., Soulimani, F., Seevinck, P.R., de Leeuw, H., Bakker, C.J.G., Luijten, P.R., van het Schip, A.D., Hennink, W.E. & Nijsen, J.F.W (2010). Holmium nanoparticles: preparation and in vitro characterization of a new device for radioablation of solid malignancies. Pharmaceutical Research, 27 (10), (pp. 2205-2212) (8 p.).
Lammers, T., Subr, V., Ulbrich, K., Peschke, P., Huber, P.E., Hennink, W.E., Storm, G. & Kiessling, F. (2010). HPMA-based polymer therapeutics improve the efficacy of surgery, of radiotherapy and of chemotherapy combinations. Nanomedicine, 5 (10), (pp. 1501-1523) (23 p.).
Teles, H., Vermonden, T., Eggink, G., Hennink, W.E. & de Wolf, F.A. (2010). Hydrogels of collagen-inspired telechelic triblock copolymers for the sustained release of proteins. Journal of Controlled Release, 147 (2), (pp. 298-303) (6 p.).
Ghassemi, A.H., van Steenbergen, M.J., Talsma, H., van Nostrum, C.F., Crommelin, D.J.A. & Hennink, W.E. (2010). Hydrophilic polyester microspheres: effect of molecular weight and copolymer composition on release of BSA. Pharmaceutical Research, 27 (9), (pp. 2008-17) (10 p.).
van Rooy, I., Cakir-Tascioglu, S., Couraud, P.O., Romero, I.A., Weksler, B., Storm, G., Hennink, W.E., Schiffelers, R.M. & Mastrobattista, E. (2010). Identification of peptide ligands for targeting to the blood-brain barrier. Pharmaceutical Research, 27 (4), (pp. 673-82) (10 p.).
Censi, R., Fieten, P.J., Di Martino, P., Hennink, W.E. & Vermonden, T. (2010). In-situ forming hydrogels by tandem thermal gelling and Michael addition reaction between thermosensitive triblock copolymers and thiolated hyaluronan. Macromolecules, 43, (pp. 5771-5778) (8 p.).
van Gaal, E.V.B., Oosting, R.S., Hennink, W.E., Crommelin, D.J.A. & Mastrobattista, E. (2010). Junk DNA enhances pEI-based non-viral gene delivery. International Journal of Pharmaceutics, 390 (1), (pp. 76-83) (8 p.).
van den Berg, J.H., Quaak, S.G.L., Beijnen, J.H., Hennink, W.E., Storm, G., Schumacher, T.N., Haanen, J.B. & Nuijen, B. (2010). Lipopolysaccharide contamination in intradermal DNA vaccination: toxic impurity or adjuvant?. International Journal of Pharmaceutics, 390 (1), (pp. 32-36) (5 p.).
Lammers, T.G.G.M., Subr, V., Ulbrich, P., Peschke, P., Huber, P.E., Hennink, W.E., Storm, G. & Kiessling, F. (2010). Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy. Advanced Engineering Materials, 12, (pp. B413-B421) (9 p.).
Vermonden, T., Jena, S.S., Barriet, D., Censi, R., van de Gucht, J., Hennink, W.E. & Siegel, R.S. (2010). Macromolecular diffusion in self-assembling biodegradable thermosensitive hydrogels. Macromolecules, 43, (pp. 782-789) (8 p.).
Talelli, M., Rijcken, C.J.F., van Nostrum, C.F., Storm, G. & Hennink, W.E. (17.02.2010). Micelles based on HPMA copolymers. Advanced Drug Delivery Reviews, 62 (2), (pp. 231-239) (9 p.).
Talelli, M., Rijcken, C.J.F., van Nostrum, C.F., Storm, G. & Hennink, W.E. (2010). Micelles based on HPMA copolymers. Advanced Drug Delivery Reviews, 62 (2), (pp. 231-9) (9 p.).
Lammers, T., Kiessling, F., Hennink, W.E. & Storm, G. (2010). Nanotheranostics and image-guided drug delivery: current concepts and future directions. Molecular Pharmaceutics, 7 (6), (pp. 1899-912) (14 p.).
Liu, J., Jiang, X., Xu, L., Wang, X., Hennink, W.E. & Zhuo, R. (2010). Novel reduction-responsive cross-linked polyethylenimine derivatives by click chemistry for nonviral gene delivery. Bioconjugate Chemistry, 21 (10), (pp. 1827-35) (9 p.).
Amidi, M., de Raad, M., de Graauw, H., van Ditmarsch, D., Hennink, W.E., Crommelin, D.J.A. & Mastrobattista, E. (2010). Optimization and quantification of protein synthesis inside liposomes. Journal of Liposome Research, 20 (1), (pp. 73-83) (11 p.).
van Hell, A.J., Fretz, M.M., Crommelin, D.J.A., Hennink, W.E. & Mastrobattista, E. (2010). Peptide nanocarriers for intracellular delivery of photosensitizers. Journal of Controlled Release, 141 (3), (pp. 347-53) (7 p.).
Censi, R., Vermonden, T., Deschout, H., Braeckmans, K., di Martino, P., de Smedt, S.C., van Nostrum, C.F. & Hennink, W.E. (2010). Photopolymerized thermosensitive poly(HPMAlactate)-PEG-based hydrogels: effect of network design on mechanical properties, degradation, and release behavior. Biomacromolecules, 11 (8), (pp. 2143-51) (9 p.).
Oerlemans, C., Bult, W., Bos, M., Storm, G., Nijsen, J.F.W & Hennink, W.E. (2010). Polymeric micelles in anticancer therapy: targeting, imaging and triggered release. Pharmaceutical Research, 27 (12), (pp. 2569-2589) (21 p.).
Lammers, T.G.G.M., Subr, V., Ulbrich, K., Hennink, W.E., Storm, G. & Kiessling, F. (2010). Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy. Nano Today, 5, (pp. 197-212) (16 p.).
De Geest, B.G., De Koker, S., Demeester, J., De Smedt, S.C. & Hennink, W.E. (2010). Self-exploding particles. Polymer Chemistry, 1, (pp. 137-148) (12 p.).
van den Berg, J.H., Oosterhuis, K., Hennink, W.E., Storm, G., Aa, L.J., Engbersen, J.F.J., Haanen, J.B., Beijnen, J.H., Schumacher, T.N. & Nuijen, B. (2010). Shielding the cationic charge of nanoparticle-formulated dermal DNA vaccines is essential for antigen expression and immunogenicity. Journal of Controlled Release, 141 (2), (pp. 234-240) (7 p.).
van de Manakker, F., Kroon-Batenburg, L.M.J., Vermonden, T., van Nostrum, C.F. & Hennink, W.E. (2010). Supramolecular hydrogels formed by ß-cyclodextrin self-association and host–guest inclusion complexes. Soft Matter, 6, (pp. 187-194) (8 p.).
van Dijk, M., van Nostrum, C.F., Hennink, W.E., Rijkers, D.T.S. & Liskamp, R.M.J. (2010). Synthesis and characterization of enzymatically biodegradable PEG and peptide based hydrogels prepared by click chemistry. Biomacromolecules, 11, (pp. 1608-1614) (7 p.).
van Dijk, M., Postma, T.M., Rijkers, D.T.S., Liskamp, R.M.J., van Nostrum, C.F. & Hennink, W.E. (2010). Synthesis and characterization of tailorable biodegradable thermoresponsive methacryloylamide polymers based on L-serine and L-threonine alkyl esters. Polymer, 51, (pp. 2478-2485) (8 p.).
van den Berg, J.H., Nuijen, B., Schumacher, T.N., Haanen, J.B., Storm, G., Beijnen, J.H. & Hennink, W.E. (2010). Synthetic vehicles for DNA vaccination. Journal of Drug Targeting, 18 (1), (pp. 1-14) (14 p.).
Verheul, R.J., van der Wal, S. & Hennink, W.E. (2010). Tailorable thiolated trimethyl chitosans for covalently stabilized nanoparticles. Biomacromolecules, 11, (pp. 1965-1971) (7 p.).
Schillemans, J.P., Hennink, W.E. & van Nostrum, C.F. (2010). The effect of network charge on the immobilization and release of proteins from chemically crosslinked dextran hydrogels. European Journal of Pharmaceutics and Biopharmaceutics, 76 (3), (pp. 329-35) (7 p.).
  2009 - Scholarly publications
Gokmen, M.T., De Geest, B.G., Hennink, W.E. & Du Prez, F.E. (2009). "Giant" Hollow Multilayer Capsules by Microfluidic Templating. ACS Applied Materials and Interfaces, 1 (6), (pp. 1196-1202) (7 p.). ISI:000267513100011.
van de Manakker, F., Vermonden, T., van Nostrum, C.F. & Hennink, W.E. (2009). Cyclodextrin-based polymeric materials: synthesis, properties, and pharmaceutical/biomedical applications. Biomacromolecules, 10, (pp. 3157-3175) (19 p.).
Oudshoorn, M.H.M., Rissmann, R., van der Coelen, D., Hennink, W.E., Ponec, M. & Bouwstra, J.A. (2009). Development of a murine model to evaluate the effect of vernix caseosa on skin barrier recovery. Experimental Dermatology, 18 (2), (pp. 178-184) (7 p.). ISI:000262469800012.
Oudshoorn, M.H.M., Rissmann, R., van der Coelen, D., Hennink, W.E., Ponec, M. & Bouwstra, J.A. (2009). Effect of synthetic vernix biofilms on barrier recovery of damaged mouse skin. Experimental Dermatology, 18 (8), (pp. 695-703) (9 p.). ISI:000268299500005.
Wilschut, K.J., van der Aa, M., Oosting, R.S., Hennink, W.E., Koning, G.A., Crommelin, D.J.A. & Mastrobattista, E. (2009). Fluorescence in situ hybridization to monitor the intracellular location and accessibility of plasmid DNA delivered by cationic polymer-based gene carriers. European Journal of Pharmaceutics and Biopharmaceutics, 72 (2), (pp. 391-396) (6 p.). ISI:000267000800014.
Verheul, R.J., Amidi, M., van Steenbergen, M.J., van Riet, E., Jiskoot, W. & Hennink, W.E. (2009). Influence of the degree of acetylation on the enzymatic degradation and in vitro biological properties of trimethylated chitosans. Biomaterials, 30 (18), (pp. 3129-3135) (7 p.). ISI:000266148200001.
Bult, W., Seevinck, P.R., Krijger, G.C., Visser, T., Kroon-Batenburg, L.M.J., Bakker, C.J.G., Hennink, W.E., van het Schip, A.D. & Nijsen, J.F.W. (2009). Microspheres with Ultrahigh Holmium Content for Radioablation of Malignancies. Pharmaceutical Research, 26 (6), (pp. 1371-1378) (8 p.). ISI:000265834600009.
Elgersma, R.C., van Dijk, M., Dechesne, A.C., van Nostrum, C.F., Hennink, W.E., Rijkers, D.T.S. & Liskamp, R.M.J. (2009). Microwave-assisted click polymerization for the synthesis of A beta(16-22) cyclic oligomers and their self-assembly into polymorphous aggregates. Organic and Biomolecular Chemistry, 7 (21), (pp. 4517-4525) (9 p.). ISI:000270795700026.
Rissmann, R., Oudshoorn, M.H.M., Zwier, R., Ponec, M., Bouwstra, J.A. & Hennink, W.E. (2009). Mimicking vernix caseosa-Preparation and characterization of synthetic biofilms. International Journal of Pharmaceutics, 372 (1-2), (pp. 59-65) (7 p.). ISI:000266025800008.
Vente, M.A.D., Nijsen, J.F.W., de Roos, R., van Steenbergen, M.J., Kaaijk, C.N.J., Koster-Ammerlaan, M.J.J., de Leege, P.F.A., Hennink, W.E., van het Schip, A.D. & Krijger, G.C. (2009). Neutron activation of holmium poly(L-lactic acid) microspheres for hepatic arterial radioembolization: a validation study. Biomedical Microdevices, 11 (4), (pp. 763-772) (10 p.). ISI:000267886400007.
de Graaf, A.J., Kooijman, M., Hennink, W.E. & Mastrobattista, E. (2009). Nonnatural Amino Acids for Site-Specific Protein Conjugation. Bioconjugate Chemistry, 20 (7), (pp. 1281-1295) (15 p.). ISI:000268137700001.
van den Berg, J.H., Nuijen, B., Beijnen, J.H., Vincent, A., van Tinteren, H., Kluge, J., Woerdeman, L.A.E., Hennink, W.E., Storm, G., Schumacher, T.N. & Haanen, J. (2009). Optimization of Intradermal Vaccination by DNA Tattooing in Human Skin. Human Gene Therapy, 20 (3), (pp. 181-189) (9 p.). ISI:000264284100001.
Tai, H.Y., Howard, D., Takae, S., Wang, W.X., Vermonden, T., Hennink, W.E., Stayton, P.S., Hoffman, A.S., Endruweit, A., Alexander, C., Howdle, S.M. & Shakesheff, K.M. (2009). Photo-Cross-Linked Hydrogels from Thermoresponsive PEGMEMA-PPGMA-EGDMA Copolymers Containing Multiple Methacrylate Groups: Mechanical Property, Swelling, Protein Release, and Cytotoxicity. Biomacromolecules, 10 (10), (pp. 2895-2903) (9 p.). ISI:000270548700024.
Censi, R., Vermonden, T., van Steenbergen, M.J., Deschout, H., Braeckmans, K., de Smedt, S.C., van Nostrum, C.F., di Martino, P. & Hennink, W.E. (2009). Photopolymerized thermosensitive hydrogels for tailorable diffusion-controlled protein delivery. Journal of Controlled Release, 140 (3), (pp. 230-6) (7 p.).
De Geest, B.G., De Koker, S., Sukhorukov, G.B., Kreft, O., Parak, W.J., Skirtach, A.G., Demeester, J., De Smedt, S.C. & Hennink, W.E. (2009). Polyelectrolyte microcapsules for biomedical applications. Soft Matter, 5 (2), (pp. 282-291) (10 p.). ISI:000262956100003.
Chaisri, W., Hennink, W.E. & Okonogi, S. (2009). Preparation and characterization of cephalexin loaded PLGA microspheres. Current Drug Delivery, 6 (1), (pp. 69-75) (7 p.).
Ghassemi, A.H., van Steenbergen, M.J., Talsma, H., van Nostrum, C.F., Jiskoot, W., Crommelin, D.J.A. & Hennink, W.E. (2009). Preparation and characterization of protein loaded microspheres based on a hydroxylated aliphatic polyester, poly (lactic-co-hydroxymethyl glycolic acid). Journal of Controlled Release, 138 (1), (pp. 57-63) (7 p.). ISI:000268826100009.
Ghassemi, A.H., van Steenbergen, M.J., Talsma, H., van Nostrum, C.F., Jiskoot, W., Crommelin, D.J.A. & Hennink, W.E. (19.08.2009). Preparation and characterization of protein loaded microspheres based on a hydroxylated aliphatic polyester, poly(lactic-co-hydroxymethyl glycolic acid). Journal of Controlled Release, 138 (1), (pp. 57-63) (7 p.).
van de Manakker, F., Braeckmans, K., el Morabit, N., De Smedt, S.C., van Nostrum, C.F. & Hennink, W.E. (2009). Protein-Release Behavior of Self-Assembled PEG-beta-Cyclodextrin/PEG-Cholesterol Hydrogels. Advanced Functional Materials, 19 (18), (pp. 2992-3001) (10 p.). ISI:000270438100016 TiPharma Spring meeting.
De Geest, B.G., De Koker, S., Demeester, J., De Smedt, S.C. & Hennink, W.E. (2009). Pulsed in vitro release and in vivo behavior of exploding microcapsules. Journal of Controlled Release, 135 (3), (pp. 268-273) (6 p.). ISI:000265702200012.
Metz, B., Jiskoot, W., Mekkes, D., Kingma, R.L., Hennink, W.E., Crommelin, D.J.A. & Kersten, G.F.A. (2009). Quality control of routine, experimental and real-time aged diphtheria toxoids by in vitro analytical techniques. Vaccine, 25, (pp. 6863-6871) (9 p.).
Meng, F.H., Hennink, W.E. & Zhong, Z. (2009). Reduction-sensitive polymers and bioconjugates for biomedical applications. Biomaterials, 30 (12), (pp. 2180-2198) (19 p.). ISI:000264512800004.
Hagenaars, N., Verheul, R.J., Mooren, I., de Jong, P.H.J.L.F, Mastrobattista, E., Glansbeek, H.L., Heldens, J.G., van den Bosch, H., Hennink, W.E. & Jiskoot, W. (2009). Relationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal influenza vaccine. Journal of Controlled Release, 140 (2), (pp. 126-33) (8 p.).
Lammers, T., Subr, V., Ulbrich, K., Peschke, P., Huber, P.E., Hennink, W.E. & Storm, G. (2009). Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers. Biomaterials, 30 (20), (pp. 3466-3475) (10 p.). ISI:000266744100013.
Rissmann, R., Oudshoorn, M.H.M., Hennink, W.E., Ponec, M. & Bouwstra, J.A. (2009). Skin barrier disruption by acetone: observations in a hairless mouse skin model. Archives of Dermatological Research, 301 (8), (pp. 609-613) (5 p.). ISI:000269055000008.
van Hell, A.J., Crommelin, D.J., Hennink, W.E. & Mastrobattista, E. (2009). Stabilization of peptide vesicles by introducing inter-peptide disulfide bonds. Pharmaceutical Research, 26 (9), (pp. 2186-93) (8 p.).
Talelli, M., Rijcken, C.J.F., Lammers, T., Seevinck, P.R., Storm, G., van Nostrum, C.F. & Hennink, W.E. (2009). Superparamagnetic Iron Oxide Nanoparticles Encapsulated in Biodegradable Thermosensitive Polymeric Micelles: Toward a Targeted Nanomedicine Suitable for Image-Guided Drug Delivery. Langmuir, 25 (4), (pp. 2060-2067) (8 p.). ISI:000263373600028.
van Dijk, M., Rijkers, D.T.S., Liskamp, R.M.J., van Nostrum, C.F. & Hennink, W.E. (2009). Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies. Bioconjugate Chemistry, 20, (pp. 2001-2016) (16 p.).
Seyednejad, S.H., Vermonden, T., Fedorovich, N.E., van Eijk, R., van Steenbergen, M.J., Dhert, W.J.A., van Nostrum, C.F. & Hennink, W.E. (2009). Synthesis and characterization of hydroxyl-functionalized caprolactone copolymers and their effect on adhesion, proliferation, and differentiation of human mesenchymal stem cells. Biomacromolecules, 10 (11), (pp. 3048-3054) (7 p.).
Lukowiak, M., Kosson, P., Hennink, W.E. & Lipikowski, A.W. (2009). Synthesis and pharmacological properties of a new fluorescent opioid peptide analog. Pharmacological Reports, 67 (4), (pp. 727-731) (5 p.). ISI:000271221700017.
van Putten, S.M., Wubben, M., Hennink, W.E., van Luyna, M.J.A. & Harmsen, M.C. (2009). The downmodulation of the foreign body reaction by cytomegalovirus encoded interleukin-10. Biomaterials, 30 (5), (pp. 730-735) (6 p.). ISI:000262552600004.
Tai, H.Y., Wang, W.X., Vermonden, T., Heath, F., Hennink, W.E., Alexander, C., Shakesheff, K.M. & Howdle, S.M. (2009). Thermoresponsive and Photocrosslinkable PEGMEMA-PPGMA-EGDMA Copolymers from a One-Step ATRP Synthesis. Biomacromolecules, 10 (4), (pp. 822-828) (7 p.). ISI:000265098800025 FIGON Dutch Medicine Days 2009.
  2008 - Scholarly publications
Carstens, M.G., van Nostrum, C.F., Verrijk, R., de Leede, L., Crommelin, D.J.A. & Hennink, W.E. (2008). A mechanistic study on the chemical and enzymatic degradation of PEG-oligo(-caprolactone) micelles. Journal of Pharmaceutical Sciences, 97, (pp. 506-518) (13 p.).
de Geest, B.G., Van Camp, W., Du Prez, F.E., de Smedt, S.C., Demeester, J. & Hennink, W.E. (2008). Biodegradable microcapsules designed via ‘click’ chemistry. Chem. Commun., (pp. 190-192) (3 p.).
Luten, J., van Nostrum, C.F., de Smedt, S.C. & Hennink, W.E. (2008). Biodegradable polymers as non-viral carriers for plasmid DNA delivery. Journal of Controlled Release, 126, (pp. 97-110) (14 p.).
de Wolf, H.K., Luten, J., Snel, C.J., Storm, G. & Hennink, W.E. (2008). Biodegradable, cationic methacrylamide-based polymers for gene delivery to ovarian cancer cells in mice. Molecular Pharmaceutics, 5, (pp. 349-357) (9 p.).
Lin, C., Blaauboer, C.J., Timoneda, M.M., Lok, M.C., van Steenbergen, M.J., Hennink, W.E., Zhong, Z., Feijen, J. & Engbersen, J.F.J. (2008). Bioreducible poly(amido amine)s with oligoamine side chains: Synthesis, characterization, and structural effects on gene delivery. Journal of Controlled Release, 126, (pp. 166-174) (9 p.).
Ramzi, A., Rijcken, C.J.F., Veldhuis, T.F.J., Schwan, D., Hennink, W.E. & van Nostrum, C.F. (2008). Core-shell structure of degradable, thermosensitive polymeric micelles studied by small-angle neutron scattering. Journal of Physical Chemistry B, 112, (pp. 784-792) (9 p.).
de Geest, B.G., Van Camp, W., Du Prez, F.E., de Smedt, S.C., Demeester, J. & Hennink, W.E. (2008). Degradable multilayer films and hollow capsules via a ‘click’ strategy. Macromolecular Rapid Communications, 29, (pp. 1111-1118) (8 p.).
Luten, J., van Steenbergen, M.J., Lok, M.C., de Graaff, A.M., van Nostrum, C.F., Talsma, H. & Hennink, W.E. (2008). Degradable PEG-folate coated poly(DMAEA-co-BA)phosphazene-based polyplexes exhibit receptor-specific gene expression. European Journal of Pharmaceutical Sciences, 33 (3), (pp. 241-251) (11 p.).
van Tomme, S.R., van Nostrum, C.F., Dijkstra, M., de Smedt, S.C. & Hennink, W.E. (2008). Effect of particle size and charge on the network properties of microsphere-based hydrogels. European Journal of Pharmaceutics and Biopharmaceutics, 70, (pp. 522-530) (9 p.).
Amidi, M., Krudys, K.M., Snel, C.J., Crommelin, D.J.A., Della Pasqua, O.E., Hennink, W.E. & Jiskoot, W. (2008). Efficacy of pulmonary insulin delivery in diabetic rats: Use of a model-based approach in the evaluation of insulin powder formulations. Journal of Controlled Release, 127, (pp. 257-266) (10 p.).
Romberg, B., Flesch, F.M., Hennink, W.E. & Storm, G. (2008). Enzyme-induced shedding of a poly(amino acid)-coating triggers contents release from dioleoyl phosphatidylethanolamine liposomes. International Journal of Pharmaceutics, 355, (pp. 108-113) (6 p.).
Lammers, T.G.G.M., Subr, V., Peschke, P., Kuhnlein, R., Hennink, W.E., Ulbrich, K., Kiessling, F., Heimann, M., Debus, J., Huber, P. & Storm, G. (2008). Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy. British Journal of Cancer, 99, (pp. 900-910) (11 p.).
van Tomme, S.R., Storm, G. & Hennink, W.E. (2008). In situ gelling hydrogels for pharmaceutical and biomedical applications. International Journal of Pharmaceutics, 355, (pp. 1-18) (18 p.).
Fretz, M.M., Dolman, M.E.M., Lacombe, M., Prakash, J., Nguyen, T.Q., Goldschmeding, R., Pato, J., Storm, G., Hennink, W.E. & Kok, R.J. (2008). Intervention in growth factor activated signaling pathways by renally targeted kinase inhibitors. Journal of Controlled Release, 132 (3), (pp. 200-207) (8 p.). Sp. Iss. SI.
Rissmann, R., Oudshoorn, M.H.M., Kocks, E., Hennink, W.E., Ponec, M. & Bouwstra, J.A. (2008). Lanolin-derived lipid mixtures mimic closely the lipid composition and organization of vernix caseosa lipids. Biochimica et Biophysica Acta - Biomembranes, 1778, (pp. 2350-2360) (11 p.).
van Tomme, S.R., Mens, A., van Nostrum, C.F. & Hennink, W.E. (2008). Macroscopic hydrogels by self-assembly of oligolactate-grafted dextran microspheres. Biomacromolecules, 9, (pp. 158-165) (8 p.).
de Geest, B.G., McShane, M., Demeester, J., de Smedt, S.C. & Hennink, W.E. (2008). Microcapsules ejecting nanosized species into the environment. Journal of the American Chemical Society, 130, (pp. 14480-14482) (3 p.).
Piest, M., Lin, C., Mateos-Timoneda, M.A., Lok, M.C., Hennink, W.E., Feijen, J. & Engbersen, J.F.J. (2008). Novel poly(amido amine)s with bioreducible disulfide linkages in their diamino-units: structure effects and in vitro gene transfer properties. Journal of Controlled Release, 130, (pp. 38-45) (8 p.).
Hofman, J.W., Carstens, M.G., van Zeeland, F., Helwig, C., Flesch, F.M., Hennink, W.E. & van Nostrum, C.F. (2008). Photocytotoxicity of mTHPC (temoporfin) loaded oligomeric micelles mediated by lipase catalyzed degradation. Pharmaceutical Research, 25, (pp. 2065-2073) (9 p.).
Vermonden, T., Fedorovich, N.E., van Geemen, D., Alblas, J., van Nostrum, C.F., Dhert, W.J.A. & Hennink, W.E. (2008). Photopolymerized thermosensitive hydrogels: synthesis, degradation, and cytocompatibility. Biomacromolecules, 9 (3), (pp. 919-926) (8 p.).
de Wolf, H.K., Johansson, N., Thong, A.T., Snel, C.J., Mastrobattista, E., Hennink, W.E. & Storm, G. (2008). Plasmid CpG depletion improves degree and duration of tumor gene expression after intravenous administration of polyplexes. Pharmaceutical Research, 25, (pp. 1654-1662) (9 p.).
Mateos-Timoneda, M.A., Lok, M.C., Hennink, W.E., Feijen, J. & Engbersen, J.F.J. (2008). Poly(amido amine)s as gene delivery vectors: effects of quaternary nicotinamide moieties in the side chains. ChemMedChem, 3, (pp. 478-486) (9 p.).
Amidi, M., Pelikaan, H.C., de Boer, A.H., Crommelin, D.J.A., Hennink, W.E. & Jiskoot, W. (2008). Preparation and physicochemical characterization of supercritically dried insulin-loaded microparticles for pulmonary delivery. European Journal of Pharmaceutics and Biopharmaceutics, 68, (pp. 191-200) (10 p.).
Dolman, M.E.M., Fretz, M.M., Segers, G.J.W., Lacombe, M., Prakash, J., Storm, G., Hennink, W.E. & Kok, R.J. (2008). Renal targeting of kinase inhibitors. International Journal of Pharmaceutics, 364, (pp. 249-257) (9 p.).
van de Manakker, F., Vermonden, T., el Morabit, N., van Nostrum, C.F. & Hennink, W.E. (2008). Rheological behavior of self-assembling PEG--cyclodextrin/PEG-cholesterol hydrogels. Langmuir, 24, (pp. 12559-12567) (9 p.).
van de Manakker, F., van der Pot, M., Vermonden, T., van Nostrum, C.F. & Hennink, W.E. (2008). Self-assembling hydrogels based on -cyclodextrin/cholesterol inclusion complexes. Macromolecules, 41, (pp. 1766-1773) (8 p.).
de Geest, B.G., de Koker, S.C., Immesoete, K., de Smedt, S.C., Demeester, J. & Hennink, W.E. (2008). Self-exploding beads releasing microcarriers. Advanced Materials, 20, (pp. 3687-3691) (5 p.).
Romberg, B., Hennink, W.E. & Storm, G. (2008). Sheddable coatings for long-circulating nanoparticles. Pharmaceutical Research, 25, (pp. 55-71) (17 p.).
Leemhuis, M., Akeroyd, N., Kruijtzer, J.A.W., van Nostrum, C.F. & Hennink, W.E. (2008). Synthesis and characterization of allyl functionalized poly-hydroxy)acids and their further dihydroxylation and epoxidation. European Polymer Journal, 44, (pp. 308-317) (10 p.).
van Dijk, M., Nollet, A., Weijers, P., Dechesne, A., van Nostrum, C.F., Hennink, W.E., Rijkers, D.T.S. & Liskamp, R.M.J. (2008). Synthesis and characterization of biodegradable peptide-based polymers prepared by microwave-assisted click chemistry. Biomacromolecules, 9, (pp. 2834-2843) (10 p.).
Verheul, R.J., Amidi, M., van der Wal, S., van Riet, E., Jiskoot, W. & Hennink, W.E. (2008). Synthesis, characterization and in vitro biological properties of O-methyl free N,N,N-trimethylated chitosan. Biomaterials, 29, (pp. 3642-3539) (104 p.).
Rissmann, R., Groenink, H.W.W., Soris, G.S., Oudshoorn, M.H.M., Hennink, W.E., Ponec, M. & Bouwstra, J.A. (2008). Temperature-induced changes in structural and physicochemical properties of vernix caseosa. Journal of Investigative Dermatology, 128, (pp. 292-299) (8 p.).
Carstens, M.G., de Jong, P.H.J.L.F, van Nostrum, C.F., Kemmink, J., Verrijk, R., de Leede, L., Crommelin, D.J.A. & Hennink, W.E. (2008). The effect of core composition in biodegradable oligomeric micelles as taxane formulations. European Journal of Pharmaceutics and Biopharmaceutics, 68, (pp. 596-606) (11 p.).
Lammers, T.G.G.M., Hennink, W.E. & Storm, G. (2008). Tumour-targeted nanomedicines: principles and practice. British Journal of Cancer, 99, (pp. 392-397) (6 p.).
  2007 - Scholarly publications
van Tomme, S.R. & Hennink, W.E. (2007). Biodegradable dextran hydrogels for protein delivery applications. Expert Review of Medical Devices, 4, (pp. 147-174) (28 p.).
de Wolf, H.K., de Raad, M., Snel, C.J., van Steenbergen, M.J., Fens, M.H.A.M., Storm, G. & Hennink, W.E. (2007). Biodegradable poly(2-dimethylamino ethylamino)phosphazene for in vivo gene delivery to tumor cells. Effect of polymer molecular weight. Pharmaceutical Research, 24, (pp. 1572-1580) (9 p.).
van der Aa, M.A.E.M., Huth, U.S., Häfele, S.Y., Schubert, R., Oosting, R.S., Mastrobattista, E., Hennink, W.E., Peschka-Süss, R., Koning, G.A. & Crommelin, D.J.A. (2007). Cellular uptake of cationic polymer-DNA complexes via caveolae plays a pivotal role in gene transfection in COS-7 cells. Pharmaceutical Research, 24, (pp. 1590-1598) (9 p.).
Zielhuis, S.W., Seppenwoolde, J.H., Bakker, C.J.G., Jahnz, U., Zonnenberg, B.A., van het Schip, A.D., Hennink, W.E. & Nijsen, J.F.W (2007). Characterization of holmium loaded alginate microspheres for multimodality imaging and therapeutic applications. Journal of Biomedical Materials Research - Part A, 82 (4), (pp. 892-898) (7 p.).
Jiang, Xulin, Lok, Martin C. & Hennink, Wim E. (2007). Degradable-brushed pHEMA-pDMAEMA synthesized via ATRP and click chemistry for gene delivery. Bioconjugate Chemistry, 18 (6), (pp. 2077-2084) (8 p.).
Jiang, X., Lok, M.C. & Hennink, W.E. (2007). Degradable-brushed pHEMA–pDMAEMA synthesized via ATRP and click chemistry for gene delivery. Bioconjugate Chemistry, 18, (pp. 2077-2084) (8 p.).
Mastrobattista, E., Hennink, W.E. & Schiffelers, R.M. (2007). Delivery of nucleic acids. Pharmaceutical Research, 24, (pp. 1561-1563) (3 p.).
Amidi, M., Pellikaan, H., Hirschberg, H., de Boer, A.H., Crommelin, D.J.A., Hennink, W.E., Kersten, G.F.A. & Jiskoot, W. (2007). Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: Preparation, characterization and evaluation in guinea pigs. Vaccine, 25, (pp. 6818-6829) (12 p.).
de Wolf, H.K., Snel, C.J., Verbaan, F.J., Schiffelers, R.M., Hennink, W.E. & Storm, G. (2007). Effect of cationic carriers on the pharmacokinetics and tumor localization of nucleic acids after intravenous administration. International Journal of Pharmaceutics, 331, (pp. 167-170) (4 p.).
Vugt-Wensink, K.D.F., Meijer, Y.J., van Steenbergen, M.J., Verrijk, R., Jiskoot, W., Crommelin, D.J.A. & Hennink, W.E. (2007). Effect of excipients on the encapsulation efficiency and release of human growth hormone from dextran microspheres. European Journal of Pharmaceutics and Biopharmaceutics, 67, (pp. 589-596) (8 p.).
Romberg, B., Oussoren, C., Snel, C.J., Hennink, W.E. & Storm, G. (2007). Effect of liposome characteristics and dose on the pharmacokinetics of liposomes coated with poly(amino acid)s. Pharmaceutical Research, 24, (pp. 2394-2401) (8 p.).
Lammers, T., Peschke, P., Kühlnlein, R., Subr, V., Ulbrich, K., Debus, J., Huber, P., Hennink, W.E. & Storm, G. (2007). Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems. Journal of Controlled Release, 117, (pp. 333-340) (8 p.).
Fedorovich, N.E., Alblas, J., de Wijn, J.R., Hennink, W.E., Verbout, A.J. & Dhert, W.J.A. (2007). Hydrogels as Extracellular Matrices for Skeletal Tissue Engineering: State-of-the-Art and Novel Application in Organ Printing. Tissue Engineering, 13 (8), (pp. 1905-1925) (21 p.).
Rijcken, C.J.F., Snel, C.J., Schiffelers, R.M., van Nostrum, C.F. & Hennink, W.E. (2007). Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies. Biomaterials, 28, (pp. 5581-5593) (13 p.).
Hiemstra, C., Zhong, Z., van Tomme, S.R., van Steenbergen, M.J., Jacobs, J.J., den Otter, W., Hennink, W.E. & Feijen, J. (2007). In vitro and in vivo protein delivery from in situ forming poly(ethylene glycol)-poly lactide hydrogels. Journal of Controlled Release, 119, (pp. 320-327) (8 p.).
Leemhuis, M., Kruijtzer, J.A.W., van Nostrum, C.F. & Hennink, W.E. (2007). In vitro hydrolytic degradation of hydroxyl-functionalized poly(alpha-hydroxy acid)s. Biomacromolecules, 8, (pp. 2943-2949) (7 p.).
de Koker, S.C., de Geest, B.G., Cuvelier, C., Ferdinanda, L., Deckers, W., Hennink, W.E., de Smedt, S.C. & Mertens, N. (2007). In vivo cellular uptake, degradation, and biocompatibility of polyelectrolyte microcapsules. Advanced Functional Materials, 17, (pp. 3754-3763) (10 p.).
Zielhuis, S.W., Nijsen, F., Seppenwoolde, J.H., Bakker, C.J.G., Krijger, G.C., Dullens, H.F.J., Zonnenberg, B.A., van Rijk, P.P., Hennink, W.E. & van het Schip, A.D. (2007). Long-term toxicity of holmium-loaded poly(L-lactic acid) microspheres in rats. Biomaterials, 28 (31), (pp. 4591-4599) (9 p.).
Lin, C., Zhong, X., Lok, M.C., Jiang, J., Hennink, W.E., Feijen, J. & Engbersen, J.F.J. (2007). Novel bioreducible poly(amido amine)s for high efficient gene delivery. Bioconjugate Chemistry, 18, (pp. 138-145) (8 p.).
Hofman, J.W., van Zeeland, F., Turker, S., Talsma, H., Lambrechts, S.A.G., Hennink, W.E., van Nostrum, C.F. & Sakharov, D. (2007). Peripheral and axial substitution of phthalocyanines with solketal groups: synthesis and in vitro evaluation for photodynamic therapy. Journal of Medicinal Chemistry, 50, (pp. 1485-1494) (10 p.).
Romberg, B., Oussoren, C., Snel, C.J., Carstens, M.G., Hennink, W.E. & Storm, G. (2007). Pharmacokinetics of poly(hydroxyethyl-l-asparagine)-coated liposomes is superior over that of PEG-coated liposomes at low lipid dose and upon repeated administration. Biochimica et Biophysica Acta - Biomembranes, 1768, (pp. 737-743) (7 p.).
Rijcken, C.J.F., Hofman, J.W., van Zeeland, F., Hennink, W.E. & van Nostrum, C.F. (2007). Photosensitiser-loaded biodegradable polymeric micelles: Preparation, characterisation and in vitro PDT efficacy. Journal of Controlled Release, 124, (pp. 144-153) (10 p.).
Romberg, B., Metselaar, J.M., Baranyi, L., Snel, C.J., Bünger, R., Hennink, W.E., Szebeni, J. & Storm, G. (2007). Poly(amino acid)s: Promising enzymatically degradable stealth coatings for liposomes. International Journal of Pharmaceutics, 331, (pp. 186-189) (4 p.).
Vugt-Wensink, K.D.F., de Vrueh, R.L., Gresnigt, M.G., Hoogerbrugge, M., van Buul-Offers, S.C., de Leede, L., Sterkman, J.G.W., Crommelin, D.J.A., Hennink, W.E. & Verrijk, R. (2007). Preclinical and clinical in vitro in vivo correlation of an hGH dextran microsphere formulation. Pharmaceutical Research, 24, (pp. 2239-2248) (10 p.).
Oudshoorn, M.H.M., Penteman, R., Rissman, R., Bouwstra, J.A., Broer, D.J. & Hennink, W.E. (2007). Preparation and characterization of structured hydrogel microparticles based on cross-linked hyperbranched polyglycerol. Langmuir, 23, (pp. 11819-11825) (7 p.).
Lin, C., Zhong, Z., Lok, M.C., Jiang, X., Hennink, W.E., Feijen, J. & Engbersen, J.F.J. (2007). Random and block copolymers of bioreducible poly(amido amine)s with high- and low-basicity amino groups: Study of DNA condensation and buffer capacity on gene transfection. Journal of Controlled Release, 123, (pp. 67-75) (9 p.).
Sutter, M., Siepmann, J., Hennink, W.E. & Jiskoot, W. (2007). Recombinant gelatin hydrogels for the sustained release of proteins. Journal of Controlled Release, 119, (pp. 301-312) (12 p.).
Hiemstra, C., Zhong, Z., van Steenbergen, M.J., Hennink, W.E. & Feijen, J. (2007). Release of model proteins and basic fibroblast growth factor from in situ forming degradable dextran hydrogels. Journal of Controlled Release, 122, (pp. 71-78) (8 p.).
van Hell, A.J., Costa, C.I.C.A., Flesch, F.M., Sutter, M., Jiskoot, W., Crommelin, D.J.A., Hennink, W.E. & Mastrobattista, E. (2007). Self-assembly of recombinant amphiphilic oligopeptides into vesicles. Biomacromolecules, 8, (pp. 2753-2761) (9 p.).
Sutter, M., Oliveira, S., Sanders, N., Lucas, B., van Hoek, A., Hink, M.A., Visser, A.J.W.G., de Smedt, S.C., Hennink, W.E. & Jiskoot, W. (2007). Sensitive spectroscopic detection of large and denatured protein aggregates in solution by use of the fluorescent dye nile red. Journal of Fluorescence, 17, (pp. 181-192) (12 p.).
Carstens, M.G., Bevernage, J.J.L., van Nostrum, C.F., van Steenbergen, M.J., Flesch, F.M., Verrijk, R., de Leede, L., Crommelin, D.J.A. & Hennink, W.E. (2007). Small oligomeric micelles based on end group modified mPeg-oligocaprolactone with monodisperse hydrophobic blocks. Macromolecules, 40, (pp. 116-122) (7 p.).
Loontjens, C.A.M., Vermonden, T., Leemhuis, M., van Steenbergen, M.J., van Nostrum, C.F. & Hennink, W.E. (2007). Synthesis and characterization of random and triblock copolymers of -caprolactone and (benzylated)hydroxymethyl glycolide. Macromolecules, 40, (pp. 7208-7216) (9 p.).
Oudshoorn, M.H.M., Rissmann, R., Bouwstra, J.A. & Hennink, W.E. (2007). Synthesis of methacrylated hyaluronic acid with tailored degree of substitution. Polymer, 48, (pp. 1915-1920) (6 p.).
van Dijk, M., Mustafa, K., Dechesne, A.C., van Nostrum, C.F., Hennink, W.E., Rijkers, D.T.S. & Liskamp, R.M.J. (2007). Synthesis of peptide-based polymers by microwave-assisted cycloaddition backbone polymerization. Biomacromolecules, 8, (pp. 327-330) (4 p.).
Paasonen, L., Romberg, B., Storm, G., Yliperttula, M., Urtti, A. & Hennink, W.E. (2007). Temperature-sensitive poly(N-(2-hydroxypropyl)methacrylamide mono/dilactate)-coated-liposomes for triggered contents release. Bioconjugate Chemistry, 18, (pp. 2131-2136) (6 p.).
de Jong, W.H., Dormans, J.A.M.A., van Steenbergen, M.J., Verharen, H.W. & Hennink, W.E. (2007). Tissue response in the rat and the mouse to degradable dextran hydrogels. Journal of Biomedical Materials Research, 83, (pp. 538-545) (8 p.).
Rijcken, C.J.F., Soga, S.O., Hennink, W.E. & van Nostrum, C.F. (2007). Triggered destabilisation of polymeric micelles and vesicles by changing polymers polarity: An attractive tool for drug delivery. Journal of Controlled Release, 120, (pp. 131-148) (18 p.).
  2006 - Scholarly publications
Romberg, B., Kettenes-van den Bosch, J.J., de Vringer, T., Storm, G. & Hennink, W.E. (2006). 1H NMR spectroscopy as a tool for determining the composition of poly(hydroxyethyl-L-asparagine)-coated liposomes. Bioconjugate Chemistry, 17, (pp. 860-864) (5 p.).
Mastrobattista, E., van der Aa, M.A.E.M., Hennink, W.E. & Crommelin, D.J.A. (2006). Artificial viruses: a nanotechnological approach to gene delivery. Nature Reviews Drug Discovery, 5, (pp. 115-121) (7 p.).
van Tomme, S.R., van Nostrum, C.F., de Smedt, S.C. & Hennink, W.E. (2006). Degradation behavior of dextran hydrogels composed of positively and negatively charged microspheres. Biomaterials, 27, (pp. 4141-4148) (8 p.).
Lammers, T., Peschke, P., Kuhnlein, R., Subr, V., Ulbrich, K., Huber, P., Hennink, W.E. & Storm, G. (2006). Effect of intratumoral injection on the biodistribution and the therapeutic potential of HPMA copolymer–based drug delivery systems. Neoplasia, 8, (pp. 788-795) (8 p.).
Leemhuis, M., van Nostrum, C.F., Kruijtzer, J.A.W., Zhong, Z.Y., ten Breteler, M.R., Dijkstra, P.J., Feijen, J. & Hennink, W.E. (2006). Functionalized poly(α-hydroxyacid)s via ring-opening polymerization: toward hydrophilic polyesters with pendant hydroxyl groups. Macromolecules, 39, (pp. 3500-3508) (9 p.).
Zielhuis, S.W., Nijsen, J.F.W, Krijger, G.C., van het Schip, A.D. & Hennink, W.E. (2006). Holmium-loaded poly(L-lactic acid) microspheres: in vitro degradation study. Biomacromolecules, 7, (pp. 2217-2223) (7 p.).
Metz, B., Kersten, G.F.A., Baart, G.J.E., de Jong, A., Meiring, H.D., ten Hove, J., van Steenbergen, M.J., Hennink, W.E., Crommelin, D.J.A. & Jiskoot, W. (2006). Identification of formaldehyde-induced modifications in proteins: reactions with insulin. Bioconjugate Chemistry, 17, (pp. 815-822) (8 p.).
Vlugt-Wensink, K.D.F., Jiang, X., Schotman, G., Kruijtzer, G., Vredenberg, A., Chung, J.T., Zhang, Z., Versluis, C., Ramos, D., Verrijk, R., Jiskoot, W., Crommelin, D.J.A. & Hennink, W.E. (2006). In vitro degradation behavior of microspheres based on cross-linked dextran. Biomacromolecules, 7 (11), (pp. 2983-2990) (8 p.).
de Geest, B.G., Vanderbroucke, R.E., Guenther, A.M., Sukhorukov, G.B., Hennink, W.E., Sander, J., Demeester, J. & de Smedt, S.C. (2006). Intracellularly degradable polyelectrolyte microcapsules. Advanced Materials, 18, (pp. 1005-1009) (5 p.).
Lin, C., Zhong, M.C., Jiang, X., Hennink, W.E., Feijen, J. & Engbersen, J.F.J. (2006). Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: synthesis and in vitro gene transfer properties. Journal of Controlled Release, 116, (pp. 130-138) (9 p.).
Luten, J., Akeroyd, N., Funhoff, A.M., Lok, M.C., Talsma, H. & Hennink, W.E. (2006). Methacrylamide polymers with hydrolysis-sensitive cationic side groups as degradable gene carriers. Bioconjugate Chemistry, 17, (pp. 1077-1084) (8 p.).
Vugt-Wensink, K.D.F., Vlugt, T.J.H., Jiskoot, W., Crommelin, D.J.A., Verrijk, R. & Hennink, W.E. (2006). Modeling the release of proteins from degrading crosslinked dextran microspheres using kinetic Monte Carlo simulations. Journal of Controlled Release, 111, (pp. 117-127) (11 p.).
Vlugt-Wensink, K.D.F., Vlugt, T.J.H., Jiskoot, W., Crommelin, D.J.A., Verrijk, R. & Hennink, W.E. (2006). Modelling the release of proteins from degrading dextran microspheres using kinetic Monte Carlo simulations. Journal of Controlled Release, 111, (pp. 117-127) (11 p.).
Jiang, X., van der Horst, A., van Steenbergen, M.J., Akeroyd, N., van Nostrum, C.F., Schoenmakers, P.J. & Hennink, W.E. (2006). Molar-mass characterization of cationic polymers for gene delivery by aqueous size-exclusion chromatography. Pharmaceutical Research, 23, (pp. 595-603) (9 p.).
Bonsted, A., Høgest, A., Mælandsmo, G.M., Prasmickaite, L., d'Oliveira, C., Hennink, W.E., van Steenis, J.H & van den Berg, K. (2006). Photochemically enhanced transduction of polymer-complexed adenovirus targeted to the epidermal growth factor receptor. Journal of Gene Medicine, 8, (pp. 286-297) (12 p.).
van Gaal, E.V.B., Hennink, W.E., Crommelin, D.J.A. & Mastrobattista, E. (2006). Plasmid engineering for controlled and sustained gene expression for nonviral gene therapy. Pharmaceutical Research, 23, (pp. 1053-1074) (22 p.).
Amidi, M., Romijn, S., Borchard, G., Junginger, H.E., Hennink, W.E. & Jiskoot, W. (2006). Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system. Journal of Controlled Release, 111, (pp. 107-116) (10 p.).
Zielhuis, S.W., Nijsen, J.F.W, de Roos, R., Krijger, G.C., van Rijk, P.P., Hennink, W.E. & van het Schip, A.D. (2006). Production of GMP-grade radioactive holmium loaded poly(l-lactic acid) microspheres for clinical application. International Journal of Pharmaceutics, 311, (pp. 69-74) (6 p.).
Zielhuis, S.W., Nijsen, J.F.W, Dorland, L., Krijger, G.C., van het Schip, A.D. & Hennink, W.E. (2006). Removal of chloroform from biodegradable therapeutic microspheres by radiolysis. International Journal of Pharmaceutics, 315 (1-2), (pp. 67-74) (8 p.).
Vermonden, T., Besseling, N.A.N., van Steenbergen, M.J. & Hennink, W.E. (2006). Rheological studies of thermosensitive triblock copolymer hydrogels. Langmuir, 22, (pp. 10180-10184) (5 p.).
Ramzi, A., Sutter, M., Hennink, W.E. & Jiskoot, W. (2006). Static light scattering and small-angle neutron scattering study on recombinant gelatin in aqueous solution. Journal of Pharmaceutical Sciences, 95, (pp. 1703-1711) (9 p.).
Rijcken, C.J.F., Leemhuis, M., Veldhuis, T.F.J., Hennink, W.E. & van Nostrum, C.F. (2006). Step-by-step synthesis of monodisperse methacrylamidoalkyl oligolactates. Macromolecular Rapid Communications, 27, (pp. 1312-1316) (5 p.).
Oudshoorn, M.H.M., Rissmann, R., Bouwstra, J.A. & Hennink, W.E. (2006). Synthesis and characterization of hyperbranched polyglycerol hydrogels. Biomaterials, 27, (pp. 5471-5479) (9 p.).
Schillemans, J.P., Flesch, F.M., Hennink, W.E. & van Nostrum, C.F. (2006). Synthesis of bilayer-coated nanogels by selective crosslinking of monomers inside liposomes. Macromolecules, 39, (pp. 5885-5890) (6 p.).
van der Aa, M.A.E.M., Mastrobattista, E., Oosting, R.S., Hennink, W.E., Koning, G.A. & Crommelin, D.J.A. (2006). The nuclear pore complex: the gateway to successful nonviral gene delivery. Pharmaceutical Research, 23 (3), (pp. 447-459) (13 p.).
  2006 - Professional publications
van Nostrum, C.F., Neradovic, D., Soga, S.O. & Hennink, W.E. (2006). Polymeric micelles with transient stability: a novel delivery concept. In S. Svenson (Eds.), Polymeric Drug Delivery I, Particulate Drug Carriers (pp. 40-54) (337 p.). Washington, DC, USA: American Chemical Society.
  2005 - Scholarly publications
Kooijman, H., Leemhuis, M., van Nostrum, C.F., Hennink, W.E. & Spek, A.L. (2005). (3S)-3-benzyloxymethyl-1,4-dioxane-2,5-dione. Acta Crystallographica Section E: Structure Reports Online, 61, (pp. O3480-O3481) (2 p.).
Kooijman, H., Leemhuis, M., van Nostrum, C.F., Hennink, W.E. & Spek, A.L. (2005). (3S,6R)-3-Benzyloxymethyl-6-methyl-1,4-dioxane-2,5-dione. Acta Crystallographica Section E: Structure Reports Online, 61, (pp. o898-o900) (3 p.).
Kooijman, H., Leemhuis, M., van Nostrum, C.F., Hennink, W.E. & Spek, A.L. (2005). (3S,6S)-3-Benzyloxymethyl-6-methyl-1,4-dioxane-2,5-dione. Acta Crystallographica Section E: Structure Reports Online, 61, (pp. O901-O903) (3 p.).
Zhong, Z., Song, Y., Lok, M.C., Hennink, W.E. & Feijen, J. (2005). A versatile family of degradable non-viral gene carriers based on poly(ester amine)s. Journal of Controlled Release, 110, (pp. 317-329) (13 p.).
van der Aa, M.A.E.M., Koning, G.A., d'Oliveira, C., Oosting, R.S., Wilschut, K.J., Hennink, W.E. & Crommelin, D.J.A. (2005). An NLS peptide covalently linked to linear DNA does not enhance transfection efficiency of cationic polymer based gene delivery systems. Journal of Gene Medicine, 7, (pp. 208-217) (10 p.).
Verbaan, F.J., Klouwenberg, P.K., van Steenis, J.H, Snel, C.J., Boerman, O., Hennink, W.E. & Storm, G. (2005). Application of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes for gene transfer into human ovarian carcinoma cells. International Journal of Pharmaceutics, 304 (1-2), (pp. 185-192) (8 p.).
Bos, G.W., Hennink, W.E., Brouwer, L.A., den Otter, W., Veldhuis, T.F.J., van Nostrum, C.F. & van Luyn, M.J.A. (2005). Biocompatibility of in situ formed dextran hydrogels crosslinked by stereocomplex formation after subcutaneous implantation in rats. Biomaterials, 26 (18), (pp. 3901-3909) (3901 p.).
Funhoff, A.M., van Nostrum, C.F., Lok, M.C., Kruijtzer, J.A.W., Crommelin, D.J.A. & Hennink, W.E. (2005). Cationic polymethacrylates with covalently linked membrane destabilizing peptides as gene delivery vectors. Journal of Controlled Release, 101 (1-3), (pp. 233-246) (14 p.).
Chung, J.T., Vlugt-Wensink, K.D.F., Hennink, W.E. & Zhang, Z. (2005). Effect of polymerization conditions on the network properties of dex-HEMA microspheres and macro-hydrogels. International Journal of Pharmaceutics, 288 (1), (pp. 51-61) (51 p.).
Romberg, B., Metselaar, J.M., deVringer, T., Motonaga, K., Kettenes-van den Bosch, J.J., Oussoren, C., Storm, G. & Hennink, W.E. (2005). Enzymatic degradation of liposome-grafted poly(hydroxyethyl L-glutamine). Bioconjugate Chemistry, 16 (4), (pp. 767-774) (8 p.).
de Wolf, H.K., Luten, J., Snel, C.J., Oussoren, C., Hennink, W.E. & Storm, G. (2005). In vivo tumor transfection mediated by polyplexes based on biodegradable poly(DMAEA)-phosphazene. Journal of Controlled Release, 109, (pp. 275-287) (13 p.).
Zielhuis, S.W., Nijsen, J.F.W, Seppenwoolde, J.H., Zonnenberg, B.A., Bakker, C.J.G., Hennink, W.E., van Rijk, P.P. & van het Schip, A.D. (2005). Lanthanide bearing microparticulate systems for multi-modality imaging and targeted therapy of cancer. Current Medicinal Chemistry - Anti-Cancer Agents, 5 (3), (pp. 303-313) (11 p.).
Pires, N.M.M., van der Hoeven, B.L., Vries, M.R., Havekes, L.M., van Vlijmen, B.J., Hennink, W.E., Quax, P.H.A. & Jukema, J.W. (2005). Local perivascular delivery of anti-restenotic agents from a drug-eluting poly(epsilon-caprolactone) stent cuff. Biomaterials, 26 (26), (pp. 5386-5394) (9 p.).
Zhong, Z.Y., Feijen, J., Lok, M.C., Hennink, W.E., Christensen, L.V., Yockman, J.W., Kim, Y.H. & Kim, S.W. (2005). Low molecular weight linear polyethylenimine-b-poly(ethylene glycol)-b-polyethylenimine triblock copolymers: Synthesis, characterization, and in vitro gene transfer properties. Biomacromolecules, 6 (6), (pp. 3440-3448) (9 p.).
van Tomme, S.R., de Geest, B.G., Braeckmans, K., de Smedt, S.C., Siepmann, F., Siepmann, J., van Nostrum, C.F. & Hennink, W.E. (2005). Mobility of model proteins in hydrogels composed of oppositely charged dextran microsphers studied by protein release and fluorescence recovery after photobleaching. Journal of Controlled Release, 110, (pp. 275-287) (13 p.).
Zhao, Y., Benita, Y., Lok, M., Kuipers, B., van der Ley, P., Jiskoot, W., Hennink, W.E., Crommelin, D.J.A. & Oosting, R.S. (2005). Multi-antigen immunization using IgG binding domain ZZ as carrier. Vaccine, 23, (pp. 5082-5090) (9 p.).
Rijcken, C.J.F., Veldhuis, T.F.J., Ramzi, A., Meeldijk, J.D., van Nostrum, C.F. & Hennink, W.E. (2005). Novel fast degradable thermosensitive polymeric micelles based on PEG-block-poly(N-(2-hydroxyethyl)methacrylamide-oligolactates). Biomacromolecules, 6 (4), (pp. 2343-2351) (9 p.).
Funhoff, A.M., Monge, S., Teeuwen, R., Koning, G.A., Schuurmans-Nieuwenbroek, N.M.E., Crommelin, D.J.A., Haddleton, D.M., Hennink, W.E. & van Nostrum, C.F. (2005). PEG shielded polymeric double-layered micelles for gene delivery. Journal of Controlled Release, 102 (3), (pp. 711-724) (14 p.).
Carstens, M.G., van Nostrum, C.F., Ramzi, A., Meeldijk, J.D., Verrijk, R., de Leede, L.L., Crommelin, D.J.A. & Hennink, W.E. (2005). Poly(ethylene glycol)-oligolactates with monodisperse hydrophobic blocks: Preparation, characterization, and behavior in water. Langmuir, 21 (24), (pp. 11446-11454) (9 p.).
van Tomme, S.R., van Steenbergen, M.J., de Smedt, S.C., van Nostrum, C.F. & Hennink, W.E. (2005). Self-gelling hydrogels based on oppositely charged dextran microspheres. Biomaterials, 26 (14), (pp. 2129-2135) (7 p.).
Zielhuis, S.W., Nijsen, J.F.W, Figueiredo, R., Feddes, B., Vredenberg, A.M., van het Schip, A.D. & Hennink, W.E. (2005). Surface characteristics of holmium-loaded poly (L-lactic acid) microspheres. Biomaterials, 26 (8), (pp. 925-932) (8 p.).
Soga, O., van Nostrum, C.F., Fens, M., Rijcken, C.J.F., Schiffelers, R.M., Storm, G. & Hennink, W.E. (2005). Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery. Journal of Controlled Release, 103 (2), (pp. 341-353) (13 p.).
Arigita, C., Luijkx, T., Jiskoot, W., Poelen, M., Hennink, W.E., Crommelin, D.J.A., van der Ley, P., van Els, C. & Kersten, G.F.A. (2005). Well-defined and potent liposomal meningococcal B vaccines adjuvated with LPS derivatives. Vaccine, 23 (43), (pp. 5091-5098) (5091 p.).
  2005 - Professional publications
Hennink, W.E., van Nostrum, C.F., Crommelin, D.J.A. & Bezemer, J.Z. (2005). Hydrogels for the controlled release of proteins. In G.S. Kwon (Eds.), Polymeric Drug Delivery Systems (36 p.). Boca Raton, Fl.: Taylor & Francis.
Verbaan, F.J., Crommelin, D.J.A., Hennink, W.E. & Storm, G. (2005). Poly(2-(dimethylamino)ethyl methacrylate)-based polymers for the delivery of genes in vitro and in vivo. In M.M Amiji (Eds.), Polymeric gene delivery. Principles and applications (pp. 107-132) (26 p.). Boca Raton, Fl.: CRC Press.
  2004 - Scholarly publications
Verbaan, F.J., Bos, G.W., Oussoren, C., Woodle, M.C., Hennink, W.E. & Storm, G. (2004). A comparative study of different cationic transfection agents for in vivo gene delivery after intravenous administration. Journal of Drug Delivery and Scientific Technology, 14, (pp. 1-7) (7 p.).
Hennink, W.E., de Jong, S.J., Bos, G.W., Veldhuis, T.F.J. & van Nostrum, C.F. (2004). Biodegradable dextran hydrogels crosslinked by stereocomplex formation for the controlled release of pharmaceutical proteins. International Journal of Pharmaceutics, 277, (pp. 99-104) (6 p.).
Hennink, W.E., De Jong, S.J., Bos, G.W., Veldhuis, T.F.J. & Van Nostrum, C.F. (11.06.2004). Biodegradable dextran hydrogels crosslinked by stereocomplex formation for the controlled release of pharmaceutical proteins. International Journal of Pharmaceutics, 277 (1-2), (pp. 99-104) (6 p.).
Funhoff, A.M., van Nostrum, C.F., Koning, G.A., Schuurmans-Nieuwenbroek, N.M.E., Crommelin, D.J.A. & Hennink, W.E. (2004). Endosomal escape of polymeric gene delivery complexes is not always enhanced by polymers buffering at low pH. Biomacromolecules, 5, (pp. 32-39) (8 p.).
Hennink, W.E., van Steenis, J.H & van Nostrum, C.F. (2004). Fast degradable polymers. In: Reflexive Polymers and Hydrogels. In N. Yui, R.J. Mrsny & K. Park (Eds.), Understanding and designing fast responsive polymeric system (pp. 401-423) (23 p.). CRC Press.
van Nostrum, C.F., Veldhuis, T.F.J., Bos, G.W. & Hennink, W.E. (2004). Hydrolytic degradation of oligo(lactid acid): a kinetic and mechanistic study. Polymer, 45, (pp. 6779-6787) (9 p.).
Metz, B., Kersten, G.F.A., Hoogerhout, P., Timmermans, H.A.M., de Jong, A., Meiring, H.D., ten Hove, J., Hennink, W.E., Crommelin, D.J.A. & Jiskoot, W. (2004). Identification of formaldehyde-induced modifications in proteins. Reactions with model peptides. Journal of Biological Chemistry, 279, (pp. 6235-6243) (9 p.).
Arigita, C., van den Berg, J., Wensink, K.D.F., van Steenbergen, M.J., Hennink, W.E., Crommelin, D.J.A., Kersten, G.F.A. & Jiskoot, W. (2004). Immunogenicity of meningococcal PorA formulations encapsulated in biodegradable microspheres. European Journal of Pharmaceutical Sciences, 21, (pp. 131-141) (11 p.).
Bos, G.W., Jacobs, J.J.L., Koten, J.W., van Tomme, S.R., Veldhuis, T., van Nostrum, C.F., den Otter, W. & Hennink, W.E. (2004). In situ crosslinked biodegradable hydrogels loaded with IL-2 are effective tools for local IL-2 therapy. European Journal of Pharmaceutical Sciences, 21, (pp. 561-567) (7 p.).
Vermonden, Tina, Van Steenbergen, Mies J., Besseling, Nicolaas A M, Marcelis, Antonius T M, Hennink, Wim E., Sudhölter, Ernst J R & Cohen Stuart, Martien A. (08.12.2004). Linear rheology of water-soluble reversible neodymium(III) coordination polymers. Journal of the American Chemical Society, 126 (48), (pp. 15802-15808) (7 p.).
Stubbe, B., Hennink, W.E., de Smedt, S.C. & Demeester, J. (2004). On the swelling pressure of hydrogels that degrade through different mechanisms. Macromolecules, 37, (pp. 8739-8744) (6 p.).
Yilmaz, G., Jongboom, R.O.J., Feil, H., van Dijk, C. & Hennink, W.E. (2004). Permeation of volatile compounds through starch films. Biomacromolecules, 5, (pp. 650-656) (7 p.).
Soga, S.O., van Nostrum, C.F., Ramzi, A., Visser, T., Soulimani, F., Frederik, P.M., Bomans, P.H.H. & Hennink, W.E. (2004). Physicochemical characterization of thermosensitive and degradable polymeric micelles. Langmuir, 20, (pp. 9388-9395) (8 p.).
Verbaan, F.J., Crommelin, D.J.A., Hennink, W.E. & Storm, G. (2004). Poly (2-dimethylamino)ethyl methacrylate)-based polymers for the delivery of genes in vitro and in vivo. In M.M. Maiji (Eds.), Polymeric Gene Delivery (pp. 107-132) (26 p.). CRC Press.
Funhoff, A.M., van Nostrum, C.F., Lok, M.C., Fretz, M.M., Crommelin, D.J.A. & Hennink, W.E. (2004). Poly(3-guanidinopropyl methacrylate): a novel cationic polymer for gene delivery. Bioconjugate Chemistry, 15, (pp. 1212-1220) (9 p.).
Soga, S.O., van Nostrum, C.F. & Hennink, W.E. (2004). Poly(N-(2-hydroxypropyl) methacrylamide mono/di lactate): a new class of biodegradable polymers with tuneable thermosensitivity. Biomacromolecules, 5, (pp. 818-821) (4 p.).
Funhoff, A.M., van Nostrum, C.F., Janssen, A.P.C.A., Fens, M.H.A.M., Crommelin, D.J.A. & Hennink, W.E. (2004). Polymer side-chain degradation as a tool to control the destabilization of polyplexes. Pharmaceutical Research, 21, (pp. 170-176) (7 p.).
Arigita, C., Jiskoot, W., Wetsdijk, J., van Ingen, C., Hennink, W.E., Crommelin, D.J.A. & Kersten, G.F.A. (2004). Stability of mono- and trivalent menigococcal outer membrane vesicle vaccines. Vaccine, 22, (pp. 629-642) (14 p.).
Verbaan, F.J., Oussoren, C., Snel, C.J., Crommelin, D.J.A., Hennink, W.E. & Storm, G. (2004). Steric stabilization of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes mediates prolonged circulation and tumor targeting in mice. Journal of Gene Medicine, 6, (pp. 64-75) (12 p.).
Neradovic, D., Soga, S.O., van Nostrum, C.F. & Hennink, W.E. (2004). The effect of the processing and formulation parameters on the size of nanoparticles based on block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) with and without hydrolytically sensitive groups. Biomaterials, 25, (pp. 2409-2418) (10 p.).
van Nostrum, C.F., Veldhuis, T.F.J., Bos, G.W. & Hennink, W.E. (2004). Tuning the degradation rate of poly(2-hydroxypropyl methacrylamide)-graft-oligo(lactid acid) stereocomplex hydrogels. Macromolecules, 37, (pp. 2113-2188) (76 p.).
  2003 - Scholarly publications
Metselaar, J.M., Bruin, P., Boer, L.W., de Vringer, T., Snel, C.J., Oussoren, C., Wauben, M.H.M., Crommelin, D.J., Storm, G. & Hennink, W.E. (2003). A novel family of L-amino acid-based biodegradable polymer-lipid conjugates for the development of long-circulating liposomes with effective drug-targeting capacity. Bioconjugate Chemistry, 14 (6), (pp. 1156-1164) (9 p.).
Leemhuis, M., van Steenis, J.H, van Uxem, M.J., van Nostrum, C.F. & Hennink, W.E. (2003). A versatile route to functionalized dilactones as monomers for the synthesis of poly(alpha-hydroxy) acids. Annalen der Pharmacie, 17, (pp. 3344-3349) (6 p.).
Neradovic, D., van Steenbergen, M.J., Vansteelant, L., Meijer, Y.J., van Nostrum, C.F. & Hennink, W.E. (2003). Degradation mechanism and kinetics of thermosensitive polyacrylamides containing lactic acid side chains. Macromolecules, 36, (pp. 7491-7498) (8 p.).
van Nostrum, C.F., de Jong, S.J., Kettenes-van den Bosch, J.J. & Hennink, W.E. (2003). Hydrogels by stereocomplex formation and their use as drug delivery matrices. In S.M. Dinh & P. Liu (Eds.), Advances in controlled drug delivery: science, technology, and products (pp. 129-141) (13 p.). Library of congres cataloging-in-publication data.
Koten, J.W., van Luyn, M.J., Cadee, J.A., Brouwer, L., Hennink, W.E., Bijleveld, C. & den Otter, W. (2003). IL-2 loaded dextran microspheres with attractive histocompatibility properties for local IL-2 cancer therapy. Cytokine, 24, (pp. 57-66) (10 p.).
Verbaan, F.J., van Dam, I., Takakura, Y., Hashida, M., Hennink, W.E. & Storm, G. (2003). Intravenous fate of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes. European Journal of Pharmaceutical Sciences, 20, (pp. 419-427) (9 p.).
Arigita, C., Bevaart, L., Everse, L.A., Koning, G.A., Hennink, W.E., Crommelin, D.J.A., van de Winkel, J.G.J., van Vugt, M.J., Kersten, G.F.A. & Jiskoot, W. (2003). Liposomal meningococcal B vaccination: Role of dendritic cell targeting in the development of a protective immune response. Infection and Immunity, 71 (9), (pp. 5210-5218) (9 p.).
Crommelin, D.J.A., Storm, G., Jiskoot, W., Stenekes, R.J.H., Mastrobattista, E. & Hennink, W.E. (2003). Nanotechnological approaches for the delivery of macromolecules. Journal of Controlled Release, 87, (pp. 81-88) (8 p.).
Metz, B., Jiskoot, W., Hennink, W.E., Crommelin, D.J.A. & Kersten, G.F.A. (2003). Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines. Vaccine, 22 (I12), (pp. 156-167) (12 p.).
van Steenis, J.H, Maarseveen, Erik M, Verbaan, F.J., Verrijk, R., Crommelin, D.J.A., Storm, G. & Hennink, W.E. (21.02.2003). Preparation and characterization of folate-targeted pEG-coated pDMAEMA-based polyplexes. Journal of Controlled Release, 87 (1-3), (pp. 167-176) (10 p.).
van Steenis, J.H, van Maarseveen, N.M., Verbaan, F.J., Verrijk, R., Crommelin, D.J.A., Storm, G. & Hennink, W.E. (2003). Preparation and characterization of folate-targeted pEG-coated pDMAEMA-based polyplexes. Journal of Controlled Release, 87, (pp. 167-176) (10 p.).
Arigita, C., Kersten, G.F.A., Hazendonk, T., Hennink, W.E., Crommelin, D.J.A. & Jiskoot, W. (2003). Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes. Vaccine, 21, (pp. 950-960) (11 p.).
Crommelin, D.J.A., Storm, G., Verrijk, R., de Leede, L., Jiskoot, W. & Hennink, W.E. (2003). Shifting paradigms: biopharmaceuticals versus low molecular weight drugs. International Journal of Pharmaceutics, 266, (pp. 3-16) (14 p.).
Stubbe, B., Horkay, F., Amsden, B., Hennink, W.E., de Smedt, S.C. & Demeester, J. (2003). Tailoring the swelling pressure of degrading dextran hydroxyethyl methacrylate hydrogels. Biomacromolecules, 4, (pp. 691-695) (5 p.).
Luten, J., van Steenis, J.H, van Someren, R., Kemmink, J., Schuurmans-Nieuwenbroek, N.M.E., Koning, G.A., Crommelin, D.J.A., van Nostrum, C.F. & Hennink, W.E. (2003). Water-soluble biodegradable cationic polyphosphazenes for gene delivery. Journal of Controlled Release, 89, (pp. 483-497) (15 p.).
  2002 - Scholarly publications
Meyvis, T.K.L., Stubbe, B., van Steenbergen, M.J., Hennink, W.E., de Smedt, S.C. & Demeester, J. (2002). A comparison between the use of dynamic mechanical analysis and oscillatory shear rheometry for the characterisation of hydrogels. International Journal of Pharmaceutics, 244, (pp. 163-168) (6 p.).
Nijsen, J.F.W., van het Schip, A.D., Hennink, W.E., Rook, D.W, van Rijk, P.P. & de Klerk, J.M.H. (2002). Advances in nuclear oncology: Microspheres for internal radionuclide therapy of liver tumours. Current Medicinal Chemistry, 9, (pp. 73-82) (10 p.).
Nijsen, J.F.W., Van Het Schip, A.D., Van Steenbergen, M.J., Zielhuis, S.W., Kroon-Batenburg, L.M.J., Van De Weert, M., Van Rijk, P.P. & Hennink, W.E. (15.04.2002). Influence of neutron irradiation on holmium acetylacetonate loaded poly(L-lactic acid) microspheres. Biomaterials, 23 (8), (pp. 1831-1839) (9 p.).
Yilmaz, G., Ongen, G., Jongboom, R.O.J., Feil, H., van Dijk, C. & Hennink, W.E. (2002). Modulated release of a volatile compound from starch matrixes via enzymatically controlled degradation. Biomacromolecules, 3, (pp. 305-311) (7 p.).
Hennink, W.E. & van Nostrum, C.F. (2002). Novel crosslinking methods to design hydrogels. Advanced Drug Delivery Reviews, 54, (pp. 13-36) (24 p.).
de Jong, S.J., van Nostrum, C.F., Kroon-Batenburg, L.M.J., Kettenes-van den Bosch, J.J. & Hennink, W.E. (2002). Oligolactate-grafted dextran hydrogels: detection of stereocomplex crosslinks by X-ray diffraction. Journal of Applied Polymer Science, 86, (pp. 289-293) (5 p.).
Cadee, J.A., de Groot, C.J., Jiskoot, W., den Otter, W. & Hennink, W.E. (2002). Release of recombinant human interleukin-2 from dextran-based hydrogels. Journal of Controlled Release, 78, (pp. 1-13) (13 p.).
van de Weert, M., van Dijkhuizen-Radersma, R., Bezemer, J., Hennink, W.E. & Crommelin, D.J.A. (2002). Reversible aggregation of lysozyme in a biodegradable amphiphilic multiblock copolymer. European Journal of Pharmaceutics and Biopharmaceutics, 54, (pp. 89-93) (5 p.).
van de Weert, M., van Steenbergen, M.J., Cleland, J.L., Heller, J., Hennink, W.E. & Crommelin, D.J.A. (2002). Semisolid, self-catalyzed poly(ortho ester)s as controlled-release systems: protein release and protein stability issues. Journal of Pharmaceutical Sciences, 91, (pp. 1065-1074) (10 p.).
Stubbe, B., Braeckmans, K., Horkay, I., Hennink, W.E., de Smedt, S.C. & Demeester, J. (2002). Swelling pressure observations on degrading dex-HEMA hydrogels. Macromolecules, 35, (pp. 2501-2505) (5 p.).
de Groot, C.J., Cadee, J.A., Koten, J.W., Hennink, W.E. & den Otter, W. (2002). Therapeutic efficacy of IL-2-loaded hydrogels in a mouse tumor model. International Journal of Cancer, 98, (pp. 134-140) (7 p.).
  2002 - Professional publications
Bos, G.W., Verrijk, R., Hennink, W.E. & Crommelin, D.J.A. (2002). Controlled release of pharmaceutical proteins from hydrogels. EBR - European Biopharmaceutical Review, Autumn, (pp. 94-101) (8 p.).
  2001 - Scholarly publications
Cadee, J.A., Brouwer, L.A., den Otter, W., Hennink, W.E. & van Luyn, M.J. (2001). A comparative biocompatibility study of microspheres based on crosslinked dextran or poly(lactic-co-glycolic)acid after subcutaneous injection in rats. Journal of Biomedical Materials Research, 56, (pp. 600-609) (10 p.).
de Jong, S.J., de Smedt, S.C., Demeester, J., van Nostrum, C.F., Kettenes-van den Bosch, J.J. & Hennink, W.E. (2001). Biodegradable hydrogels based on stereocomplex formation between lactic acid oligomers grafted to dextran. Journal of Controlled Release, 72, (pp. 47-56) (10 p.).
De Jong, S.J., De Smedt, Stefaan C., Demeester, J., Van Nostrum, C.F., Kettenes-van den Bosch, J.J. & Hennink, W.E. (14.05.2001). Biodegradable hydrogels based on stereocomplex formation between lactic acid oligomers grafted to dextran. Journal of Controlled Release, 72 (1-3), (pp. 47-56) (10 p.).
Nijsen, J.F.W., van Steenbergen, M.J., Kooijman, H., Talsma, H., Kroon-Batenburg, L.M.J., van de Weert, M., van Rijk, P.P., de Witte, A., van het Schip, A.D. & Hennink, W.E. (2001). Characterization of poly (L-lactic acid) microspheres loaded with holmium aceylacetonate. Biomaterials, 22, (pp. 3073-3081) (9 p.).
Nijsen, J.F.W., Van Steenbergen, M.J., Kooijman, H., Talsma, H., Kroon-Batenburg, L.M.J., Van De Weert, M., Van Rijk, P.P., De Witte, A., Van Het Schip, A.D. & Hennink, W.E. (15.11.2001). Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate. Biomaterials, 22 (22), (pp. 3073-3081) (9 p.).
Storm, G., Mastrobattista, E., Verbaan, F.J., Crommelin, D.J.A. & Hennink, W.E. (2001). Design of methacrylate-based polyplexes for tumor targeting. Gene Therapy, 6, (pp. 143-148) (6 p.).
Crommelin, D.J.A., Hennink, W.E. & Storm, G. (2001). Drug targeting systems: fundamental and applications to parenteral drug delivery. In A.M. Hillery, A.W. Lloyd & J. Swarbick (Eds.), Drug delivery and applications to parenteral drug delivery (pp. 117-144) (28 p.).
Steendam, R., van Steenbergen, M.J., Hennink, W.E., Frijlink, H.W. & Lerk, C.F. (2001). Effect of molecular weight and glass transition on relaxation and release behaviour of poly(dl-lactic acid) tablets. Journal of Controlled Release, 70, (pp. 71-82) (12 p.).
Yilmaz, H., Jongboom, R.O.J., Feil, H. & Hennink, W.E. (2001). Encapsulation of sunflower oil in starch matrices via extrusion: effect of the interfacial properties and processing conditions on the formation of dispersed phase morphologies. Journal of Carbohydrate Chemistry, 45, (pp. 403-410) (8 p.).
Stenekes, R.J.H., Talsma, H. & Hennink, W.E. (2001). Formation of dextran hydrogels by crystallization. Biomaterials, 22, (pp. 1891-1898) (8 p.).
van de Weert, M., Haris, P.I., Hennink, W.E. & Crommelin, D.J.A. (2001). Fourtier transform infrared spectrometric analysis of protein conformation: effect of the sampling method and stress factors. Analytical Biochemistry, 297, (pp. 160-169) (10 p.).
Hennink, W.E., van de Wetering, P., Storm, G. & Crommelin, D.J.A. (2001). Gene delivery with water-soluble cationic methacrylate/methacrylamide polymers. In H. de Ruiter (Eds.), Proceedings of the 6th International Symposium on Adjuvants for Agrochemicals (pp. 595-607) (13 p.).
Bos, G.W., Verrijk, R., Franssen, O., Bezemer, J., Hennink, W.E. & Crommelin, D.J.A. (2001). Hydrogels for the controlled release of pharmaceutical proteins. Biopharm Europe, 13, (pp. 64-74) (11 p.).
Bos, G.W., Verrijk, R., Franssen, O., Bezemer, J., Hennink, W.E. & Crommelin, D.J.A. (2001). Hydrogels for the controlled release of pharmaceutical proteins. Pharmaceutical Development and Technology, 25, (pp. 110-120) (11 p.).
de Groot, C.J., van Luyn, M.J., van Dijk-Wolthuis, W.N.E., Cadee, J.A., Plantinga, J.A., den Otter, W. & Hennink, W.E. (2001). In vitro biocompatibility of biodegradable dextran-based hydrogels tested with human fibroblasts. Biomaterials, 22, (pp. 1197-1203) (7 p.).
Mastrobattista, E., Kapel, R.H.G., Eggenhuisen, M.H., Roholl, P.J.M., Crommelin, D.J.A., Hennink, W.E. & Storm, G. (2001). Lipid-coated polyplexes for targeted gene delivery to ovarian carcinoma cells. Cancer Gene Therapy, 8, (pp. 405-413) (9 p.).
Hennink, W.E., Cadee, J.A., de Jong, S.J., Franssen, R.J.H., Talsma, H. & van Dijk-Wolthuis, W.N.E. (2001). Molecular design of degradable dextran hydrogels for the controlled release of proteins. In E. Chielline, J. Sunamoto, C. Migliaresi, R.M. Ottenbrite & D. Cohn (Eds.), Biomedical polymers and polymer therapeutics (pp. 3-18) (16 p.). Kluwer Academic/Plenum Publishers.
de Jong, S.J., Arias, E.R., Rijkers, D.T.S., van Nostrum, C.F., Kettenes-van den Bosch, J.J. & Hennink, W.E. (2001). New insights into the hydrolytic degradation of poly(lactic acid): participation of the alcohol terminus. Polymer, 42, (pp. 2795-2802) (8 p.).
de Jong, S.J., Ruiz-Arias, E., Rijkers, D.T.S., van Nostrum, C.F., Kettenes-van den Bosch, J.J. & Hennink, W.E. (2001). New insights into the hydrolytic degradation of poly(lactic acid): Participation of the alochol terminus. Polymer, 42, (pp. 2795-2802) (8 p.).
Hennink, W.E. (2001). New insights into the hydroytic degradation of poly(lactic acid): participation of the alcohol terminus. Polymer, 42, (pp. 2795-2802) (8 p.).
Meyvis, T.K.L., de Smedt, S.C., Stubbe, B., Hennink, W.E. & Demeester, J. (2001). On the release of proteins from degrading dextran methacrylate hydrogels and the correlation with rheologic properties of the hydrogels. Pharmaceutical Research, (pp. 1593-1599) (7 p.).
Cadee, J.A., van Steenbergen, M.J., Versluis, C., Heck, A.J.R., Underberg, W.J.M., den Otter, W., Jiskoot, W. & Hennink, W.E. (2001). Oxidation of Recombinant Human interleukin-2 by Potassium Peroxodisulfate. Pharmaceutical Research, 18, (pp. 1461-1467) (7 p.).
Hennink, W.E., Cherng, J-Y, Jiskoot, W., Talsma, H. & Crommelin, D.J.A. (2001). Pharmaceutical aspects of polymer-based non-viral gene delivery systems: experience with p(DMAEMA)-pCMV-lacZ polyplexes. S.T.P. Pharma Sciences, 11, (pp. 11-19) (9 p.).
De Jong, S.J., van Eerdenbrugh, B., Van Nostrum, C.F., Kettenes-van den Bosch, J.J. & Hennink, W.E. (28.04.2001). Physically crosslinked dextran hydrogels by stereocomplex formation of lactic acid oligomers: Degradation and protein release behavior. Journal of Controlled Release, 71 (3), (pp. 261-275) (15 p.).
de Jong, S.J., van Eerdenbrugh, B., van Nostrum, C.F., Kettenes-van den Bosch, J.J. & Hennink, W.E. (2001). Physically crosslinked dextran hydrogels by stereocomplex formation of lactic acid oligomers: degradation and protein release behavior. Journal of Controlled Release, 71, (pp. 261-275) (15 p.).
de Jong, S.J., van Eerdenbrugh, B., van Nostrum, C.F., Kettenes-van den Bosch, J.J. & Hennink, W.E. (2001). Physically crosslinked dextran hydrogels by stereocomplex formation of lactic acid oligomers: degradation and protein release behaviour. Journal of Controlled Release, 71, (pp. 261-275) (15 p.).
Nijsen, J.F.W., Rook, D.W, Brandt, C.J.W.M., Meyer, R., Dullens, H.F.J., Zonnenberg, B.A., de Klerk, J.M.H., van Rijk, P.P., Hennink, W.E. & van het Schip, A.D. (2001). Targeting of liver tumour in rats by selective delivery of holmium-166 loaded microspheres: a biodistribution study. Radioactive Holmium poly (L-lacticacid) microspheres for treatment of liver malignancies (pp. 95-108) (14 p.). Utrecht.
Nijsen, J.F.W., Rook, D.W, Brandt, C.J.W.M., Meyer, R., Dullens, H.F.J., Zonnenberg, B.A., de Klerk, J.M.H., van Rijk, P.P., Hennink, W.E. & van het Schip, A.D. (2001). Targeting of liver tumour in rats by selective delivery of holmium-166 loaded microspheres: a biodistribution study. European Journal Of Nuclear Medicine, 28, (pp. 743-749) (7 p.).
Verbaan, F.J., Oussoren, C., van Dam, I., Takakura, Y., Hashida, M., Crommelin, D.J.A., Hennink, W.E. & Storm, G. (2001). The fate of poly(2-dimethyl amino ethyl)methacrylate-based polyplexes after intravenous administration. International Journal of Pharmaceutics, 214, (pp. 99-101) (3 p.).
Neradovic, D., van Nostrum, C.F. & Hennink, W.E. (2001). Thermoresponsive polymeric micelles with controlled instability based on hydrolytically sensitive N-isopropylacrylamide copolymers. Macromolecules, (pp. 7589-7591) (3 p.).
van Es, R.J., Nijsen, J.F.W., Dullens, H.F.J., Kicken, M., van der Bilt, A., Hennink, W.E., Koole, R. & Slootweg, P.J. (2001). Tumour embolization of the Vx2 rabbilt head and neck cancer model with Dextran hydrogel and Holmium-poly(L-lactic acid) microspheres: a radionuclide and histological pilot study. Journal of Cranio-Maxillo-Facial Surgery, 29, (pp. 289-297) (9 p.).
Bos, G.W., Crommelin, D.J.A. & Hennink, W.E. (2001). Water-soluble cationic methacrylate polymers for nonviral gene delivery. Methods of Molecular Medicine (pp. 35-60) (26 p.).
  2001 - Professional publications
Stenekes, R.J.H., Loebis, A.E., Fernandes, C.M., Crommelin, D.J.A. & Hennink, W.E. (2001). Degradable dextran microspheres for the controlled release of liposomes. International Journal of Pharmaceutics, 214, (pp. 17-20) (4 p.).
  2000 - Scholarly publications
Hennink, W.E., Cadee, J.A., de Jong, S.J., Franssen, O., Stenekes, R.J.H., van Nostrum, C.F., Talsma, H. & van Dijk-Wolthuis, W.N.E. (2000). Biodegradable hydrogels for the controlled release of pharmaceutical applications. In K.D. Park, I.C. Kwon, N. Yui, S.Y. Jeong & K. Park (Eds.), Biomaterials and drug delivery toward new millennium (pp. 131-147) (17 p.). Han Rim Won Publising.
de Smedt, S.C., Demeester, J. & Hennink, W.E. (2000). Cationic polymer based gene delivery systems. Pharmaceutical Research, 17, (pp. 113-116) (4 p.).
Stenekes, R.J.H., Loebis, A.E., Fernandes, C.M., Crommelin, D.J.A. & Hennink, W.E. (2000). Controlled release of liposomes from biodegradable dextran microspheres: a novel delivery concept. Pharmaceutical Research, 17, (pp. 690-695) (6 p.).
van de Wetering, P., Schuurmans-Nieuwenbroek, N.M.E., van Steenbergen, M.J., Crommelin, D.J.A. & Hennink, W.E. (2000). Copolymers of 2-(dimethylamino)ethyl methacrylate with ethoxytriethylene glycol methacrylate or N-vinyl-pyrrolidone as gene transfer agents. Journal of Controlled Release, 64, (pp. 193-203) (11 p.).
Zuidam, N.J., Posthuma, G., de Vries, E.T., Crommelin, D.J.A., Hennink, W.E. & Storm, G. (2000). Effects of physicochemical characteristics of poly(2-(dimethylamino)ethylmethacrylate)-based polyplexes on cellular association and internalization. Journal of Drug Targeting, 8, (pp. 51-66) (16 p.).
Cadee, J.A., van Luyn, M.J., Brouwer, L.A., Plantinga, J.A., van Wachem, P.B., de Groot, C.J., den Otter, W. & Hennink, W.E. (2000). In vivo biocompatibility of dextran-based hydrogels. Journal of Biomedical Materials Research, 50, (pp. 397-404) (8 p.).
Meyvis, T.K.L., de Smedt, S.C., Demeester, J. & Hennink, W.E. (2000). Influence of the degradation mechanism of hydrogels on their elastic and swelling properties during degradation. Macromolecules, 33, (pp. 4717-4725) (9 p.).
van de Weert, M., van 't Hof, R., van der Weerd, J., Heeren, R.M., Posthuma, G., Hennink, W.E. & Crommelin, D.J.A. (2000). Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques. Journal of Controlled Release, 68, (pp. 31-40) (10 p.).
Storm, G., van de Wetering, P., Zuidam, N.J., Cherng, J-Y, Talsma, H., Crommelin, D.J.A. & Hennink, W.E. (2000). Methacrylate-based polyplexes as transfection agent. NATO Sci.ser., Ser.A 323. Targeting of Drugs: Strategies for Gene Constructs and Delivery (pp. 192-199) (8 p.).
de Jong, S.J., de Smedt, S.C., Wahls, M.W.C., Demeester, J., Kettenes-van den Bosch, J.J. & Hennink, W.E. (2000). Novel self-assembled hydrogels by stereocomplex formation in aqueous solution of enatiomeric lactic acid oligomers grafted to dextran. Macromolecules, 33, (pp. 3680-3686) (7 p.).
Stenekes, R.J.H. & Hennink, W.E. (2000). polymerization kinetics of dextran-bound methacrylate in an aqueous two phase system. Polymer, 41, (pp. 5563-5569) (7 p.).
Stenekes, R.J.H., de Smedt, S.C., Demeester, J., Sun, G., Zhang, Z. & Hennink, W.E. (2000). Pore sizes in hydrated dextran microspheres. Biomacromolecules, 1, (pp. 696-703) (8 p.).
van de Weert, M., Hennink, W.E. & Jiskoot, W. (2000). Protein instability in pokly(lactic-co-glycoloc acid) microparticles. Pharmaceutical Research, 17, (pp. 1159-1167) (9 p.).
Bos, G.W., Trullas-Jimeno, A., Jiskoot, W., Crommelin, D.J.A. & Hennink, W.E. (2000). Sterilization of poly(dimethylamino)ethyl methacrylate-based transfer complexes. International Journal of Pharmaceutics, 211, (pp. 79-88) (10 p.).
van de Weert, M., Hoechstetter, J., Hennink, W.E. & Crommelin, D.J.A. (2000). The effect of a water/organic interface on the structural stability of lysozyme. Journal of Controlled Release, 68, (pp. 351-359) (9 p.).
  1999 - Scholarly publications
van Dijk-Wolthuis, W.N.E., van de Wetering, P., Hinrichs, W.L.J., Hofmeyer, L.J.F., Liskamp, R.M.J., Crommelin, D.J.A. & Hennink, W.E. (1999). A versatile method for the conjugation of proteins and peptides to poly(2-(dimethylamino)ethyl) methacrylate. Bioconjugate Chemistry, 10, (pp. 589-597) (9 p.).
van Dijk-Wolthuis, W.N.E., van de Wetering, P., Hinrichs, Wouter L J, Hofmeyer, L.J.F., Liskamp, R.M.J., Crommelin, D.J.A. & Hennink, W.E. (1999). A versatile method for the conjugation of proteins and peptides to poly[2-(dimethylamino)ethyl methacrylate]. Bioconjugate Chemistry, 10 (4), (pp. 687-692) (6 p.).
Arigita, C., Zuidam, N.J., Crommelin, D.J.A. & Hennink, W.E. (1999). Association and dissociation characteristics of polymer/DNA complexes used for gene delivery. Pharmaceutical Research, 16, (pp. 1534-1541) (8 p.).
Fonseca Chacharo, M.J., Storm, G., Hennink, W.E., Gerritsen, W.R. & Haisma, H.J. (1999). Cationic polymeric gene delivery of beta-glucuronidase for doxorubicin prodrug therapy. Journal of Gene Medicine, 1, (pp. 404-417) (14 p.).
van de Wetering, P., Schuurmans-Nieuwenbroek, N.M.E., Hennink, W.E. & Storm, G. (1999). Comparative transfection studies of human ovarian carcinama cells in vitro, ex vivo and in vivo with poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes. Journal of Gene Medicine, 1, (pp. 156-165) (10 p.).
Franssen, O., Stenekes, R.J.H. & Hennink, W.E. (1999). Controlled release of a model protein from enzymatically-degrading dextran microspheres. Journal of Controlled Release, 59, (pp. 219-228) (10 p.).
Franssen, O., Vandervennet, L., Roders, P. & Hennink, W.E. (1999). Degradable dextran hydrogels: controlled release of a model protein from cylinders and microspheres. Journal of Controlled Release, 60, (pp. 211-221) (11 p.).
Cherng, J-Y, Schuurmans-Nieuwenbroek, N.M.E., Jiskoot, W., Talsma, H., Zuidam, N.J. & Hennink, W.E. (1999). Effect of DNA Topology on the transfection efficiency of poly(2-(dimethylamino)ethyl methacrylate)-plasmid complexes. Journal of Controlled Release, 60, (pp. 343-353) (11 p.).
den Otter, W., Cadee, J.A., Gavhumende, R., de Groot, C.J., Hennink, W.E. & Stewart, R.J.E. (1999). Effective cancer therapy with a single injection of interleukin-2 at the site of the tumour. Cancer Immunology and Immunotherapy, 48, (pp. 419-420) (2 p.).
Franssen, O., van Rooijen, R.D., de Boer, D., Maes, R.A.A. & Hennink, W.E. (1999). Enzymatic degradation of crosslinked dextrans. Macromolecules, 32, (pp. 2896-2902) (7 p.).
Franssen, O., van Ooijen, R.D., de Boer, D., Maes, R.A.A. & Hennink, W.E. (1999). Enzymatic Degradation of Cross-Linked Dextrans. Macromolecules, 32, (pp. 2896) (1 p.).
Stenekes, R.J.H. & Hennink, W.E. (1999). Equilibrium water content of microspheres based on crosslinked dextran. International Journal of Pharmaceutics, 189, (pp. 131-135) (5 p.).
Wink, Th., de Beer, J., Hennink, W.E., Bult, A. & van Bennekom, W.P. (1999). Interaction between Plasmid DNA and Cationic Polymers Studied by Surface Plasmon Resonance Spectrometry. Analytical Chemistry, 71, (pp. 801-805) (4 p.).
Wink, T., de Beer, J., Hennink, W.E., Bult, A. & van Bennekom, W.P. (1999). Interaction between plasmid DNA and cationic polymers studied byh surface plasmon resonance spectrometry. Analytical Chemistry, 71, (pp. 801-805) (5 p.).
den Otter, W., Balemans, L.T.N., Battermann, J.J., Bernsen, M.R., Cadee, J.A., Dobrowolski, Z., Everse, L.A., Fiszer-Maliszewska, L., Gavhumende, R., Groot, J.W., de Groot, K., Hennink, W.E., Hill, F.W., Jürgenliemk-Schulz, I.M., Klein, W.R., Koten, J.W., Maas, R.A., Steerenberg, P.A., Stewart, R.J.E. & Zembala, M. (1999). Local low-dose IL-2 therapy. Hepato-Gastroenterology, 46, (pp. 1280-1286) (7 p.).
Cherng, J-Y, Talsma, H., Crommelin, D.J.A. & Hennink, W.E. (1999). Long term stability of poly((2-dimethylamino)ethyl methacrylate)-based gene delivery systems. Pharmaceutical Research, 16, (pp. 1417-1423) (7 p.).
Neradovic, D., Hinrichs, W.L.J., Kettenes-van den Bosch, J.J. & Hennink, W.E. (1999). Poly (N-isopropylarcrylamide) with Hydrolyzable Lactic Acid Ester Side Groups: a new type of Thermosensitive Polymer. Macromolecular Rapid Communications, 20, (pp. 577-581) (4 p.).
Neradovic, D., Hinrichs, W.L.J., Kettenes-van den Bosch, J.J. & Hennink, W.E. (1999). Poly(N-isopropylacrylamide) with hydrolyzable lactic acid side groups: a new type of thermosensitive polymer. Macromolecular Rapid Communications, 20, (pp. 577-581) (5 p.).
Meyvis, T.K.L., de Smedt, S.C., Demeester, J. & Hennink, W.E. (1999). Rheological monitoring of long-term degrading polymer hydrogels. Journal of Rheology, 43, (pp. 933-950) (18 p.).
Cherng, J-Y, van de Wetering, P., Talsma, H., Crommelin, D.J.A. & Hennink, W.E. (1999). Stabilization of polymer-based gene delivery systems. Journal of Controlled Release, 183, (pp. 25-28) (4 p.).
van de Wetering, P., Moret, E.E., Schuurmans-Nieuwenbroek, N.M.E., van Steenbergen, M.J. & Hennink, W.E. (1999). Structure-activity relationships of water-soluble cationic methacrylate/methacrylamide polymers for nonviral gene delivery. Bioconjugate Chemistry, 10, (pp. 687-692) (6 p.).
Cadee, J.A., de Kerf, M., de Groot, C.J., den Otter, W. & Hennink, W.E. (1999). Synthesis and characterization of 2-(methacryloyloxy)ethyl-(di)-L-lactate and their application in dextran-based hydrogels. Polymer, 40, (pp. 6877-6881) (5 p.).
Cherng, J-Y, Talsma, H., Verrijk, R., Crommelin, D.J.A. & Hennink, W.E. (1999). The effect of formulation parameters on the size of poly((2-dimethylamino)ethyl methacrylate)-plasmid complexes. European Journal of Pharmaceutics and Biopharmaceutics, 47, (pp. 215-224) (10 p.).
Stenekes, R.J.H., Franssen, O., Bommel, E.M.G., Crommelin, D.J.A. & Hennink, W.E. (1999). The use of aqueous PEG/dextran phase separation for the preparation of dextran microspheres. International Journal of Pharmaceutics, 183, (pp. 29-32) (4 p.).
van Es, R.J.J., Franssen, O., Dullens, H.F.J., Bernsen, M.R., Bosman, F., Hennink, W.E. & Slootweg, P.J. (1999). The VX2 carcinoma in the rabbit auricle as an experimental model for intra-arterial embolization of head and neck squamous cell carcinoma with dextran microspheres. Laboratory Animals, 33, (pp. 175-184) (10 p.).
Hinrichs, W.L.J., Schuurmans-Nieuwenbroek, N.M.E., van de Wetering, P. & Hennink, W.E. (1999). Themosensitive polymers as carriers for DNA delivery. Journal of Controlled Release, 60, (pp. 249-259) (11 p.).
  1998 - Scholarly publications
van de Wetering, P., Cherng, J-Y, Talsma, H., Crommelin, D.J.A. & Hennink, W.E. (1998). 2-(dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents. Journal of Controlled Release, 53, (pp. 145-153) (9 p.).
van de Wetering, P., Zuidam, N.J., van Steenbergen, M.J., van der Houwen, O.A.G.J., Underberg, W.J.M. & Hennink, W.E. (1998). A mechanistic study of the hydroltic stability of Poly(2-(dimethyl)aminoethyl methacrylate). Macromolecules, 31, (pp. 8063-8068) (6 p.).
van de Wetering, P., Zuidam, N.J., van Steenbergen, M.J., van der Houwen, O.A.G.J., Underberg, W.J.M. & Hennink, W.E. (1998). A mechanistic study of the hydrolytic stability of poly (2-(dimethylamino) ethyl methacrylate). Macromolecules, 31, (pp. 8063-8068) (6 p.).
Franssen, O. & Hennink, W.E. (1998). A Novel preparation method for polymeric microparticles without the use of organic solvents. International Journal of Pharmaceutics, 168, (pp. 1-7) (7 p.).
de Jong, S.J., van Dijk-Wolthuis, W.N.E., Kettenes-van den Bosch, J.J., Schuyl, P.J.W. & Hennink, W.E. (1998). Monodisperse Enantiomeric Lactic Acid Oligomers: Preparation, Charac-terisation, and Stereocomplex Formation. Macromolecules, 31, (pp. 6397-6402) (6 p.).
de Jong, S.J., van Dijk-Wolthuis, W.N.E., Kettenes-van den Bosch, J.J., Schuyl, P.J.W. & Hennink, W.E. (1998). Monodisperse enantiomeric lactic acid oligomers: preparation, characterization, and stereocomplex formation. Macromolecules, 31, (pp. 6397-6402) (6 p.).
Talsma, H., Cherng, J-Y, van de Wetering, P., Crommelin, D.J.A. & Hennink, W.E. (1998). Poly(2-(dimethyl)aminoethyl methacrylate) nanoparticles for gene transfection. In J.E. Diederichs & R.H. Muller (Eds.), Future Strategies for Drug Delivery with Particulate Systems Systems (pp. 177-183) (7 p.). Stuttgart Germany: CRC Press Medpharm. GmbH. Scient. Publ..
van de Weert, M., van 't Hof, R., Hennink, W.E. & Crommelin, D.J.A. (1998). Stability of pharmaceutical proteins in particulate carriers. In S. Frokjaer, L. Christrup & P. Krogsgaard-Larsen (Eds.), Peptide and Protein Drug Delivery (pp. 359-375) (17 p.). Copenhagen: Munksgaard.
Stenekes, R.J.H., Franssen, O., Bommel, E.M.G., Crommelin, D.J.A. & Hennink, W.E. (1998). The preparation of dextran microspheres in an all-aqueous system: Effect of the formulation parameters on particle characteristics. Pharmaceutical Research, 15, (pp. 557-561) (5 p.).
  1997 - Scholarly publications
van Dijk-Wolthuis, W.N.E., Tsang, S.K.Y., Kettenes-van den Bosch, J.J. & Hennink, W.E. (1997). A new class of polymerizable dextrans with hydrolyzable groups: Hydroxye-thyl methacrylated dextran with and without oligolactate spacer. Polymer, 38, (pp. 6235-6242) (8 p.).
van Dijk-Wolthuis, W.N.E., Tsang, S.K.Y., van Steenbergen, M.J., Hoogeboom, C. & Hennink, W.E. (1997). Degradation and release behavior of dextran-based hydrogels. Macromolecules, 30, (pp. 4639-4645) (7 p.).
van Dijk-Wolthuis, W.N.E., van Steenbergen, M.J., Underberg, W.J.M. & Hennink, W.E. (1997). Degradation kinetics of methacrylated dextrans in aqueous solution. Journal of Pharmaceutical Sciences, 86, (pp. 413-417) (5 p.).
Franssen, O., Vos, O.P. & Hennink, W.E. (1997). Delayed release of a model protein from enzymatically degrading dextran hydrogels. Journal of Controlled Release, 44, (pp. 237-245) (9 p.).
Hennink, W.E., Franssen, O., van Dijk-Wolthuis, W.N.E. & Talsma, H. (1997). Dextran hydrogels for the controlled release of proteins. Journal of Controlled Release, 48, (pp. 107-114) (8 p.).
van der Voort Maarschalk, K., Zuurman, K., van Steenbergen, M.J., Hennink, W.E., Vromans, H., Bolhuis, G.K. & Lerk, C.F. (1997). Effect of compaction temperature on consolidation of amorphous copolymers with different glass transition temperatures. Pharmaceutical Research, 14, (pp. 415-419) (5 p.).
Franssen, O., van Ooijen, R.D., de Boer, D., Maes, R.A.A., Herron, J.N. & Hennink, W.E. (1997). Enzymatic degradation of methacrylated dextrans. Macromolecules, (pp. 91-95) (5 p.).
Cherng, J-Y, van de Wetering, P., Talsma, H., Crommelin, D.J.A. & Hennink, W.E. (1997). Freeze-drying of poly((2-dimethylami-no)ethylmethacrylate)-based gene delivery systems. Pharmaceutical Research, 14, (pp. 1837-1840) (4 p.).
Schlicher, E.J.A.M., Postma, N.S., Zuidema, J., Talsma, H. & Hennink, W.E. (1997). Preparation and characterization of poly(d,l-lactic-co-glycolic acid) microsphe-res containing desferrioxamine. International Journal of Pharmaceutics, 153, (pp. 235-245) (11 p.).
van Dijk-Wolthuis, W.N.E., Kettenes-van den Bosch, J.J., van der Kerk-van Hoof, A.C. & Hennink, W.E. (1997). Reaction of dextran with glycidyl methacrylate: an unexpected transesterification. Macromolecules, 30, (pp. 3411-3413) (3 p.).
van de Wetering, P., Cherng, J-Y, Talsma, H. & Hennink, W.E. (1997). Relation between the transfection efficiency and cytotoxicity of poly((2-dimethylamino)- ethylmethacrylate)-plasmid complexes. Journal of Controlled Release, 49, (pp. 59-71) (13 p.).
Talsma, H., Cherng, J-Y, Lehrmann, H., Malgorzata, K., Ogris, M., Hennink, W.E., Cotton, M. & Wagner, E. (1997). Stabilization of gene delivery systems by freeze-drying. International Journal of Pharmaceutics, 157, (pp. 233-238) (6 p.).
van Dijk-Wolthuis, W.N.E., van de Water, L., van de Wetering, P., van Steenbergen, M.J., Kettenes-van den Bosch, J.J., Schuyl, P.J.W. & Hennink, W.E. (1997). Synthesis and characterization of poly-L-lysine with controlled low molecular weight. Macromolecular Chemistry and Physics, 198, (pp. 3893-3907) (15 p.).
de Smedt, S.C., Meyvis, T.K.L., Demeester, J., van Oostveldt, P., Blonk, J.C.G. & Hennink, W.E. (1997). The diffusion of macromolecules in dextran glycidyl methacryla-te solutions and gels as studied by confocal laser microscopy. Macromolecules, 30, (pp. 4863-4870) (8 p.).
  1996 - Scholarly publications
Hennink, W.E., Talsma, H., Borchert, J.C.H., de Smedt, S.C. & Demeester, J. (1996). Controlled release of proteins from dextran hydrogels. Journal of Controlled Release, 39, (pp. 47-55) (9 p.).
Cherng, J-Y, van de Wetering, P., Talsma, H., Crommelin, D.J.A. & Hennink, W.E. (1996). Effect of size and serum proteins on transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles. Pharmaceutical Research, 13, (pp. 1038-1042) (5 p.).
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Gegenereerd op 2018-06-20 23:01:12
Additional functions and activities
  • Editor for Special Issues for Journal of Controlled Release 
  • Member of the Editorial Board of Pharmaceutical Research and Bioconjugate Chemistry 
Gegenereerd op 2018-06-20 23:01:12
Full name
prof. dr. ir. W.E. Hennink Contact details
David de Wiedgebouw

Universiteitsweg 99
Room 3.72
3584 CG  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 6964
Phone number (department) +31 30 253 7306
Gegenereerd op 2018-06-20 23:01:12
Last updated 07.10.2016