Dr. S. (Silvia) Mihaila

David de Wiedgebouw
Universiteitsweg 99
3584 CG Utrecht

Dr. S. (Silvia) Mihaila

Assistant Professor
Pharmacology
s.mihaila@uu.nl

Publications

2022

Scholarly publications

Lacueva-Aparicio, A., Soares Lindoso, R., Mihaila, S., & Giménez, I. (2022). Role of extracellular matrix components and structure in new renal models in vitro. Frontiers in Physiology.
Koch, S. E., Verhaegh, F. L. P., Smink, S., Mihăilă, S. M., Bouten, C. V. C., & Smits, A. I. P. M. (2022). Donor Heterogeneity in the Human Macrophage Response to a Biomaterial Under Hyperglycemia In Vitro. Tissue engineering. Part C, Methods, 28(8), 440-456. https://doi.org/10.1089/ten.TEC.2022.0066
Favero, C., Giordano, L., Mihaila, S. M., Masereeuw, R., Ortiz, A., & Sanchez-Niño, M. D. (2022). Postbiotics and Kidney Disease. Toxins, 14(9), 1-17. [623]. https://doi.org/10.3390/toxins14090623
Genderen, A. M. V., G Valverde, M., Capendale, P. E., Kersten, V., Sendino Garví, E., Schuurmans, C. C. L., Ruelas, M., Soeiro, J. T., Tang, G., Janssen, M. J., Jansen, J., Mihăilă, S. M., Vermonden, T., Zhang, Y. S., & Masereeuw, R. (2022). Co-axial Printing of Convoluted Proximal Tubule for Kidney Disease Modeling. Biofabrication, 14(4), 1-16. [044102]. https://doi.org/10.1088/1758-5090/ac7895
García Valverde, M., Ferreira Faria, J., Sendino Garví, E., Janssen, M. J., Masereeuw, R., & Mihaila, S. (2022). Organs-on-chip technology: a tool to tackle genetic kidney diseases. Pediatric Nephrology, 37(12), 2985-2996. https://doi.org/10.1007/s00467-022-05508-2
Ahmed, S., Sparidans, R. W., Lu, J., Mihaila, S. M., Gerritsen, K. G. F., & Masereeuw, R. (2022). A robust, accurate, sensitive LC-MS/MS method to measure indoxyl sulfate, validated for plasma and kidney cells. Biomedical Chromatography, 36(5), 1-10. [e5307]. https://doi.org/10.1002/bmc.5307

2021

Scholarly publications

King, J., Mihaila, S. M., Ahmed, S., Truckenmüller, R., Giselbrecht, S., Masereeuw, R., & Carlier, A. (2021). The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study. Toxins, 13(10), 1-19. [674]. https://doi.org/10.3390/toxins13100674
Faria, J., Gerritsen, K. G. F., Nguyen, T. Q., Mihaila, S. M., & Masereeuw, R. (2021). Diabetic proximal tubulopathy: Can we mimic the disease for in vitro screening of SGLT inhibitors? European Journal of Pharmacology, 908, 1-11. [174378]. https://doi.org/10.1016/j.ejphar.2021.174378
Giordano, L., Mihaila, S. M., Eslami Amirabadi, H., & Masereeuw, R. (2021). Microphysiological Systems to Recapitulate the Gut–Kidney Axis. Trends in Biotechnology, 39(8), 811-823. https://doi.org/10.1016/j.tibtech.2020.12.001

2020

Scholarly publications

Pot, M. W., Mihaila, S. M., Te Brinke, D., van der Borg, G., Oosterwijk, E., Daamen, W. F., & van Kuppevelt, T. H. (2020). Introduction of Specific 3D Micromorphologies in Collagen Scaffolds Using Odd and Even Dicarboxylic Acids. ACS Omega, 5(8), 3908-3916. https://doi.org/10.1021/acsomega.9b03350
Liu, K., Veenendaal, T., Wiendels, M., Ruiz-Zapata, A. M., van Laar, J., Kyranas, R., Enting, H., van Cranenbroek, B., Koenen, H. J. P. M., Mihaila, S. M., Oosterwijk, E., & Kouwer, P. H. J. (2020). Synthetic Extracellular Matrices as a Toolbox to Tune Stem Cell Secretome. ACS applied materials & interfaces, 12(51), 56723-56730. https://doi.org/10.1021/acsami.0c16208
Mihaila, S. M., Faria, J., Stefens, M. F. J., Stamatialis, D., Verhaar, M. C., Gerritsen, K. G. F., & Masereeuw, R. (2020). Drugs commonly applied to kidney patients may compromise renal tubular uremic toxins excretion. Toxins, 12(6), [391]. https://doi.org/10.3390/toxins12060391

2019

Scholarly publications

Liu, K., Mihaila, S. M., Rowan, A., Oosterwijk, E., & Kouwer, P. H. J. (2019). Synthetic Extracellular Matrices with Nonlinear Elasticity Regulate Cellular Organization. Biomacromolecules, 20(2), 826-834. https://doi.org/10.1021/acs.biomac.8b01445
Faria, J., Ahmed, S., Gerritsen, K. G. F., Mihaila, S. M., & Masereeuw, R. (2019). Kidney-based in vitro models for drug-induced toxicity testing. Archives of Toxicology, 93, 3397–3418. https://doi.org/10.1007/s00204-019-02598-0

2018

Scholarly publications

Sloff, M., Janke, H. P., de Jonge, P. K. J. D., Tiemessen, D. M., Kortmann, B. B. M., Mihaila, S. M., Geutjes, P. J., Feitz, W. F. J., & Oosterwijk, E. (2018). The Impact of γ-Irradiation and EtO Degassing on Tissue Remodeling of Collagen-based Hybrid Tubular Templates. ACS Biomaterials Science and Engineering, 4(9), 3282-3290. https://doi.org/10.1021/acsbiomaterials.8b00369
van Gelder, M. K., Mihaila, S. M., Jansen, J., Wester, M., Verhaar, M. C., Joles, J. A., Stamatialis, D., Masereeuw, R., & Gerritsen, K. G. F. (2018). From portable dialysis to a bioengineered kidney. Expert Review of Medical Devices, 15(5), 323-336. https://doi.org/10.1080/17434440.2018.1462697

2017

Scholarly publications

Janke, H. P., Bohlin, J., Lomme, R. M. L. M., Mihaila, S. M., Hilborn, J., Feitz, W. F. J., & Oosterwijk, E. (2017). Bioinspired coupled helical coils for soft tissue engineering of tubular structures - Improved mechanical behavior of tubular collagen type I templates. Acta Biomaterialia, 59, 234-242. https://doi.org/10.1016/j.actbio.2017.06.038
Mihaila, S. M., Resende, M. F., Reis, R. L., Gomes, M. E., & Marques, A. P. (2017). Interactive endothelial phenotype maintenance and osteogenic differentiation of adipose tissue stromal vascular fraction SSEA-4+ -derived cells. Journal of Tissue Engineering and Regenerative Medicine, 11(7), 1998-2013. https://doi.org/10.1002/term.2096

2014

Scholarly publications

Mihaila, S. M., Gaharwar, A. K., Reis, R. L., Khademhosseini, A., Marques, A. P., & Gomes, M. E. (2014). The osteogenic differentiation of SSEA-4 sub-population of human adipose derived stem cells using silicate nanoplatelets. Biomaterials, 35(33), 9087-99. https://doi.org/10.1016/j.biomaterials.2014.07.052
Gaharwar, A. K., Mihaila, S. M., Kulkarni, A. A., Patel, A., Di Luca, A., Reis, R. L., Gomes, M. E., van Blitterswijk, C., Moroni, L., & Khademhosseini, A. (2014). Amphiphilic beads as depots for sustained drug release integrated into fibrillar scaffolds. Journal of controlled release : official journal of the Controlled Release Society, 187, 66-73. https://doi.org/10.1016/j.jconrel.2014.04.035
Gaharwar, A. K., Mukundan, S., Karaca, E., Dolatshahi-Pirouz, A., Patel, A., Rangarajan, K., Mihaila, S. M., Iviglia, G., Zhang, H., & Khademhosseini, A. (2014). Nanoclay-enriched poly(ɛ-caprolactone) electrospun scaffolds for osteogenic differentiation of human mesenchymal stem cells. Tissue Engineering. Part A, 20(15-16), 2088-101. https://doi.org/10.1089/ten.tea.2013.0281
Mihaila, S. M., Popa, E. G., Reis, R. L., Marques, A. P., & Gomes, M. E. (2014). Fabrication of endothelial cell-laden carrageenan microfibers for microvascularized bone tissue engineering applications. Biomacromolecules, 15(8), 2849-60. https://doi.org/10.1021/bm500036a

2013

Scholarly publications

Gaharwar, A. K., Mihaila, S. M., Swami, A., Patel, A., Sant, S., Reis, R. L., Marques, A. P., Gomes, M. E., & Khademhosseini, A. (2013). Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells. Advanced Materials, 25(24), 3329-36. https://doi.org/10.1002/adma.201300584
Patel, A., Gaharwar, A. K., Iviglia, G., Zhang, H., Mukundan, S., Mihaila, S. M., Demarchi, D., & Khademhosseini, A. (2013). Highly elastomeric poly(glycerol sebacate)-co-poly(ethylene glycol) amphiphilic block copolymers. Biomaterials, 34(16), 3970-3983. https://doi.org/10.1016/j.biomaterials.2013.01.045
Zhang, H., Patel, A., Gaharwar, A. K., Mihaila, S. M., Iviglia, G., Mukundan, S., Bae, H., Yang, H., & Khademhosseini, A. (2013). Hyperbranched polyester hydrogels with controlled drug release and cell adhesion properties. Biomacromolecules, 14(5), 1299-310. https://doi.org/10.1021/bm301825q
Mihaila, S. M., Frias, A. M., Pirraco, R. P., Rada, T., Reis, R. L., Gomes, M. E., & Marques, A. P. (2013). Human adipose tissue-derived SSEA-4 subpopulation multi-differentiation potential towards the endothelial and osteogenic lineages. Tissue Engineering. Part A, 19(1-2), 235-46. https://doi.org/10.1089/ten.TEA.2012.0092
Mihaila, S. M., Gaharwar, A. K., Reis, R. L., Marques, A. P., Gomes, M. E., & Khademhosseini, A. (2013). Photocrosslinkable kappa-carrageenan hydrogels for tissue engineering applications. Advanced healthcare materials, 2(6), 895-907. https://doi.org/10.1002/adhm.201200317