search
Nederlands Edit
search NL

Dr. S.H. (Sophie) Bots

Assistant Professor 
Science
Pharmaceutical sciences
Pharmacoepi. and Clinical Pharmacol.
Pharmacoepi. and Clinical Pharmacol.
David de Wiedgebouw
Universiteitsweg 99
Kamer 0
3584 CG Utrecht

Dr. S.H. (Sophie) Bots

Assistant Professor
Pharmacoepi. and Clinical Pharmacol.
s.h.bots@uu.nl
Profile Publications Research Teaching Ancillary activities Contact
Profile Publications Research Teaching Ancillary activities Contact
Areas of expertise
Research areas

Publications

2025

Scholarly publications

Bots, S. H., Brown, J., Wong, A. Y. S., Martin, I., Douglas, I., Klungel, O. H., & Schultze, A. (2025). Core Concepts: Self-Controlled Designs in Pharmacoepidemiology. Pharmacoepidemiology and Drug Safety, 34(1), Article e70071. https://doi.org/10.1002/pds.70071
https://research-portal.uu.nl/ws/files/252569161/Pharmacoepidemiology_and_Drug_-_2025_-_Bots_-_Core_Concepts_Self_Controlled_Designs_in_Pharmacoepidemiology_1_.pdf
Schultze, A., Martin, I., Messina, D., Bots, S., Belitser, S., Carreras-Martínez, J. J., Correcher-Martinez, E., Urchueguía-Fornes, A., Martín-Pérez, M., García-Poza, P., Villalobos, F., Pallejà-Millán, M., Bissacco, C. A., Segundo, E., Souverein, P., Riefolo, F., Durán, C. E., Gini, R., Sturkenboom, M., ... Douglas, I. (2025). Corrigendum to “A comparison of four self-controlled study designs in an analysis of COVID-19 vaccines and myocarditis using five European databases” [Vaccine 42 (12) (2024) 3039–3048, (S0264410X2400330X), (10.1016/j.vaccine.2024.03.043)]. Vaccine, 44, 126438. Article 126438. https://doi.org/10.1016/j.vaccine.2024.126438
https://research-portal.uu.nl/ws/files/249003919/1-s2.0-S0264410X24011204-main.pdf

2024

Scholarly publications

Bots, S. H., Belitser, S., Groenwold, R. H. H., Durán, C. E., Riera-Arnau, J., Schultze, A., Messina, D., Segundo, E., Douglas, I., Carreras, J. J., Garcia-Poza, P., Gini, R., Huerta, C., Martín-Pérez, M., Martin, I., Paoletti, O., Bissacco, C. A., Correcher-Martínez, E., Souverein, P., ... Klungel, O. H. (2024). Applying two approaches to detect unmeasured confounding due to time-varying variables in a self-controlled risk interval design evaluating COVID-19 vaccine safety signals, using myocarditis as a case example. American Journal of Epidemiology, Article kwae172. Advance online publication. https://doi.org/10.1093/aje/kwae172
Canto, E. D., Uijl, A., Onland-Moret, N. C., Bots, S. H., Hofstra, L., Tulevski, I., Asselbergs, F. W., van der Harst, P., Somsen, G. A., & den Ruijter, H. M. (2024). Simplification of a registry-based algorithm for ejection fraction prediction in heart failure patients: Applicability in cardiology centres of the Netherlands. PLoS One, 19(11), Article e0310023. https://doi.org/10.1371/journal.pone.0310023
https://research-portal.uu.nl/ws/files/245387703/journal.pone.0310023.pdf
Schultze, A., Martin, I., Messina, D., Bots, S., Belitser, S., José Carreras-Martínez, J., Correcher-Martinez, E., Urchueguía-Fornes, A., Martín-Pérez, M., García-Poza, P., Villalobos, F., Pallejà-Millán, M., Alberto Bissacco, C., Segundo, E., Souverein, P., Riefolo, F., Durán, C. E., Gini, R., Sturkenboom, M., ... Douglas, I. (2024). A comparison of four self-controlled study designs in an analysis of COVID-19 vaccines and myocarditis using five European databases. Vaccine, 42(12), 3039-3048. https://doi.org/10.1016/j.vaccine.2024.03.043
https://dspace.library.uu.nl/bitstream/handle/1874/451673/1-s2.0-S0264410X2400330X-main.pdf?sequence=1

2023

Scholarly publications

Hempenius, M., Bots, S. H., Groenwold, R. H. H., de Boer, A., Klungel, O. H., & Gardarsdottir, H. (2023). Bias in observational studies on the effectiveness of in hospital use of hydroxychloroquine in COVID-19. Pharmacoepidemiology and Drug Safety, 32(9), 1001-1011. https://doi.org/10.1002/pds.5632
https://dspace.library.uu.nl/bitstream/handle/1874/432863/Pharmacoepidemiology_and_Drug_-_2023_-_Hempenius_-_Bias_in_observational_studies_on_the_effectiveness_of_in_hospital_use_of.pdf?sequence=1

2022

Scholarly publications

Bots, S. H., Onland-Moret, N. C., & den Ruijter, H. M. (2022). Addressing persistent evidence gaps in cardiovascular sex differences research – the potential of clinical care data. Frontiers in Global Women's Health, 3, 1-6. https://doi.org/10.3389/fgwh.2022.1006425
https://dspace.library.uu.nl/bitstream/handle/1874/427093/fgwh_03_1006425.pdf?sequence=1
Bots, S. H., Schreuder, M. M., Roeters van Lennep, J. E., Watson, S., van Puijenbroek, E., Onland-Moret, N. C., & den Ruijter, H. M. (2022). Sex Differences in Reported Adverse Drug Reactions to Angiotensin-Converting Enzyme Inhibitors. JAMA network open, 5(4), 1-4. Article e228224. https://doi.org/10.1001/jamanetworkopen.2022.8224
https://dspace.library.uu.nl/bitstream/handle/1874/425737/bots_2022_ld_220071_1649860022.93644.pdf?sequence=1
Bots, S. H., Onland-Moret, N. C., Jancev, M., Hollander, M., Tulevski, I. I., Hofstra, L., Somsen, G. A., & den Ruijter, H. M. (2022). Statins are associated with a large reduction in all-cause mortality in women from a cardiac outpatient population. Open Heart, 9(1), 1-9. Article e001900. https://doi.org/10.1136/openhrt-2021-001900
https://dspace.library.uu.nl/bitstream/handle/1874/425736/e001900.full.pdf?sequence=1
Bots, S. H., Riera-Arnau, J., Belitser, S. V., Messina, D., Aragón, M., Alsina, E., Douglas, I. J., Durán, C. E., García-Poza, P., Gini, R., Herings, R. M. C., Huerta, C., Sisay, M. M., Martín-Pérez, M., Martin, I., Overbeek, J. A., Paoletti, O., Pallejà-Millán, M., Schultze, A., ... Sturkenboom, M. C. J. M. (2022). Myocarditis and pericarditis associated with SARS-CoV-2 vaccines: A population-based descriptive cohort and a nested self-controlled risk interval study using electronic health care data from four European countries. Frontiers in Pharmacology, 13, 1-12. Article 1038043. https://doi.org/10.3389/fphar.2022.1038043
https://dspace.library.uu.nl/bitstream/handle/1874/425732/fphar_13_1038043.pdf?sequence=1
Bots, S. H., Groenwold, R. H. H., & Dekkers, O. M. (2022). Using electronic health record data for clinical research: a quick guide. European Journal of Endocrinology, 186(4), E1-E6. https://doi.org/10.1530/EJE-21-1088
https://dspace.library.uu.nl/bitstream/handle/1874/424462/1479_683X_EJE_21_1088.pdf?sequence=1
Siegersma, K. R., Evers, M., Bots, S. H., Groepenhoff, F., Appelman, Y., Hofstra, L., Tulevski, I. I., Somsen, G. A., den Ruijter, H. M., Spruit, M., & Onland-Moret, N. C. (2022). Development of a Pipeline for Adverse Drug Reaction Identification in Clinical Notes: Word Embedding Models and String Matching. JMIR Medical Informatics, 10(1), 1-13. Article e31063. https://doi.org/10.2196/31063
https://dspace.library.uu.nl/bitstream/handle/1874/422269/PDF_1_.pdf?sequence=1
Klamer, TA., Bots, SH., Neefs, J., Tulevski, II., Ruijter, HMD., Somsen, GA., & de, G. JR. (2022). Rate and rhythm control treatment in the elderly and very elderly patients with atrial fibrillation: an observational cohort study of 1,497 patients. Current Problems in Cardiology, 47(10), 1-19. Article 100996. https://doi.org/10.1016/j.cpcardiol.2021.100996
https://dspace.library.uu.nl/bitstream/handle/1874/428328/1_s2.0_S0146280621002115_main.pdf?sequence=1

2021

Scholarly publications

Groepenhoff, F., Klaassen, RGM., Valstar, GB., Bots, SH., Onland-Moret, NC., Den, R. HM., Leiner, T., & Eikendal, ALM. (2021). Evaluation of non-invasive imaging parameters in coronary microvascular disease: a systematic review. BMC Medical Imaging, 21(1), 1-22. Article 5. https://doi.org/10.1186/s12880-020-00535-7
https://dspace.library.uu.nl/bitstream/handle/1874/413231/s12880_020_00535_7.pdf?sequence=1
Bots, S. H., Inia, J. A., & Peters, S. A. E. (2021). Medication Adherence After Acute Coronary Syndrome in Women Compared With Men: A Systematic Review and Meta-Analysis. Frontiers in Global Women's Health, 2, 1-9. Article 637398. https://doi.org/10.3389/fgwh.2021.637398
https://dspace.library.uu.nl/bitstream/handle/1874/413230/fgwh_02_637398.pdf?sequence=1
Bots, SH., Siegersma, KR., Onland-Moret, NC., Asselbergs, FW., Somsen, GA., Tulevski, II., den, R. HM., & Hofstra, L. (2021). Routine clinical care data from thirteen cardiac outpatient clinics: design of the Cardiology Centers of the Netherlands (CCN) database. BMC Cardiovascular Disorders, 21(1), Article 287. https://doi.org/10.1186/s12872-021-02020-7
https://dspace.library.uu.nl/bitstream/handle/1874/413229/s12872_021_02020_7.pdf?sequence=1
Bots, SH., Onland-Moret, NC., Tulevski, II., van, D. H. P., Cramer, MJM., Asselbergs, FW., Somsen, GA., & den, R. HM. (2021). Heart failure medication dosage and survival in women and men seen at outpatient clinics. Heart, 107(21), 1748-1755. https://doi.org/10.1136/heartjnl-2021-319229
https://dspace.library.uu.nl/bitstream/handle/1874/413228/1748.full.pdf?sequence=1

2020

Scholarly publications

Groepenhoff, F., Eikendal, ALM., Bots, SH., van, O. AM., Overmars, LM., Kapteijn, D., Pasterkamp, G., Reiber, JHC., Hautemann, D., Menken, R., Wittekoek, ME., & den, R. HM. (2020). Cardiovascular imaging of women and men visiting the outpatient clinic with chest pain or discomfort: design and rationale of the ARGUS Study. BMJ Open. https://doi.org/10.1136/bmjopen-2020-040712
https://dspace.library.uu.nl/bitstream/handle/1874/428302/e040712.full.pdf?sequence=1
Groepenhoff, F., Eikendal, ALM., Onland-Moret, NC., Bots, SH., Menken, R., Tulevski, II., Somsen, AG., Hofstra, L., & den, R. HM. (2020). Coronary artery disease prediction in women and men using chest pain characteristics and risk factors: an observational study in outpatient clinics. BMJ Open, 10(4). https://doi.org/10.1136/bmjopen-2019-035928
https://dspace.library.uu.nl/bitstream/handle/1874/428305/e035928.full.pdf?sequence=1

2019

Scholarly publications

Bots, SH., & den, R. HM. (2019). Recommended Heart Failure Medications and Adverse Drug Reactions in Women. Circulation, 139(12). https://doi.org/10.1161/circulationaha.118.037585
Bots, SH., Groepenhoff, F., Eikendal, ALM., Tannenbaum, C., Rochon, PA., Regitz-Zagrosek, V., Miller, VM., Day, D., Asselbergs, FW., & den, R. HM. (2019). Adverse Drug Reactions to Guideline-Recommended Heart Failure Drugs in Women: A Systematic Review of the Literature. JACC. Heart failure, 7(3), 258-266. https://doi.org/10.1016/j.jchf.2019.01.009
Valstar, GB., Bots, SH., Groepenhoff, F., Gohar, A., Rutten, F. H., Leiner, T., Cramer, MJM., Teske, AJ., Suciadi, LP., Menken, R., Pasterkamp, G., Asselbergs, FW., Hofstra, L., & den, R. HM. (2019). Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic. BMJ Open, 9(6). https://doi.org/10.1136/bmjopen-2018-028408
https://dspace.library.uu.nl/bitstream/handle/1874/428304/e028408.full.pdf?sequence=1
Groepenhoff, F., Bots, SH., Kessler, EL., Sickinghe, AA., Eikendal, ALM., Leiner, T., & den, R. HM. (2019). Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease. Journal of Cardiovascular Translational Research, 13, 39-46. https://doi.org/10.1007/s12265-019-09906-0

2018

Scholarly publications

Peters, SAE., Bots, SH., & Woodward, M. (2018). Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank. Journal of the American Heart Association. https://doi.org/10.1161/jaha.117.008507
Bots, S. H., Zuidgeest, M. G. P., Gohar, A., Eikendal, A. L. M., Petrelli, A., van Os-Medendorp, H., van der Schaaf, M. F., van Sorge, N. M., van Wijk, M., Middendorp, S., Speksnijder, C. M., Klipstein-Grobusch, K., Seyfert-Margolis, V., Mollema, E., van Wijk, F., & den Ruijter, H. M. (2018). Women in translational medicine: Tools to break the glass ceiling. Frontiers in Medicine, 5, 1-6. Article 330. https://doi.org/10.3389/fmed.2018.00330
https://dspace.library.uu.nl/bitstream/handle/1874/377581/fmed_05_00330_1_.pdf?sequence=1

2017

Scholarly publications

Bots, SH., Peters, SAE., & Woodward, M. (2017). Sex differences in coronary heart disease and stroke mortality: a global assessment of the effect of ageing between 1980 and 2010. BMJ Global Health. https://doi.org/10.1136/bmjgh-2017-000298

2016

Scholarly publications

Bots, SH., van, D. G. Y., Nathoe, HM., de, B. GJ., Kappelle, JL., Visseren, FL., Westerink, J., & Group, SMART. S. (2016). The influence of baseline risk on the relation between HbA1c and risk for new cardiovascular events and mortality in patients with type 2 diabetes and symptomatic cardiovascular disease. Cardiovascular Diabetology, 15. https://doi.org/10.1186/s12933-016-0418-1
https://dspace.library.uu.nl/bitstream/handle/1874/428303/s12933_016_0418_1.pdf?sequence=1
Backholer, K., Peters, SAE., Bots, SH., Peeters, A., Huxley, RR., & Woodward, M. (2016). Sex differences in the relationship between socioeconomic status and cardiovascular disease: a systematic review and meta-analysis. Journal of Epidemiology and Community Health. https://doi.org/10.1136/jech-2016-207890
See publications on the UU Research Portal

Go to

Services

About UU