prof. dr. R.M. (Raymond) Schiffelers
Associate Professor
Pharmaceutical sciences - Pharmaceutics
Gegenereerd op 2018-01-23 23:07:15


I obtained my PhD degree from Erasmus University Medical Center Rotterdam, The Netherlands.  My thesis focused on liposomal targeting of antimicrobial agents. From 2000-2011, I worked at the dept Pharmaceutics of  Utrecht University working on polymers, micelles and liposomes, loaded with small molecular weight drugs as well as biologicals, targeting a variety of diseases. Within this period, I spent 2002-2003 working for Intradigm Co. (USA) on formulations for in vivo targeting of siRNA. In 2007, I obtained a Vidi grant from NWO to start my own research line, in 2009 I received the Galenus Research Award for my drug delivery work and in 2010 was awarded an ERC Starting Grant (consolidator phase) to investigate extracellular vesicles for drug delivery. In 2011, I moved to University Medical Center Utrecht where I complement my research lines on drug targeting with investigations on nanoparticles in diagnostic applications.

Currently I am coordinating the H2020 project B-SMART on targeting RNA to the brain and national HighTech Systems Materials project (Targeting of multiple myeloma)/KWF-STW Technology for Oncology (Targeting glioblastoma)/NWO-CW Launchpad for Innovative Future Technologies (Innovative diagnostics for glioblastoma). In addition I particpate in several EU and national projects on nanomedicine.

Scientific expertise
Gegenereerd op 2018-01-23 23:07:17
Curriculum vitae Download PDF
Gegenereerd op 2018-01-23 23:07:17
All publications
  2017 - Scholarly publications
Goh, Wei Jiang, Zou, Shui, Ong, Wei Yi, Torta, Federico, Alexandra, Alvarez Fernandez, Schiffelers, Raymond M, Storm, G, Wang, Jiong Wei, Czarny, Bertrand & Pastorin, Giorgia (30.10.2017). Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems - a Cost-Effective Alternative. Scientific Reports, 7 (1), (pp. 14322).
Allijn, Iris E., Czarny, Bertrand M S, Wang, Xiaoyuan, Chong, Suet Yen, Weiler, Marek, da Silva, Acarilia Eduardo, Metselaar, Josbert M., Lam, Carolyn Su Ping, Pastorin, Giorgia, de Kleijn, Dominique P V, Storm, G, Wang, Jiong Wei & Schiffelers, Raymond M. (10.02.2017). Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction. Journal of Controlled Release, 247, (pp. 127-133) (7 p.).
Verhoef, Johan J F, Barendrecht, Arjan D, Nickel, Katrin F, Dijkxhoorn, Kim, Kenne, Ellinor, Labberton, Linda, McCarty, Owen J T, Schiffelers, Raymond, Heijnen, Harry F G, Hendrickx, Antoni P A, Schellekens, Huub, Fens, Marcel H, de Maat, Steven, Renné, Thomas & Maas, Coen (23.03.2017). Polyphosphate nanoparticles on the platelet surface trigger contact system activation. Blood, 129 (12), (pp. 1707-1717) (11 p.). © 2017 by The American Society of Hematology..
  2016 - Scholarly publications
Allijn, Iris E., Schiffelers, Raymond M. & Storm, G (15.06.2016). Comparison of pharmaceutical nanoformulations for curcumin - Enhancement of aqueous solubility and carrier retention. International Journal of Pharmaceutics, 506 (1-2), (pp. 407-413) (7 p.).
Allijn, Iris E., Vaessen, Stefan F C, Quarles Van Ufford, Linda C., Beukelman, Kees J., De Winther, Menno P J, Storm, G & Schiffelers, Raymond M. (01.05.2016). Head-to-Head comparison of anti-inflammatory performance of known natural products in vitro. PLoS One, 11 (5).
Deshantri, Anil K., Kooijmans, Sander A A, Kuijpers, Sylvia A., Gomes Coimbra, Maria, Hoeppener, Astrid, Storm, G, Fens, Marcel H A M & Schiffelers, Raymond M. (10.12.2016). Liposomal prednisolone inhibits tumor growth in a spontaneous mouse mammary carcinoma model. Journal of Controlled Release, 243, (pp. 243-249) (7 p.).
Wang, J.W., Allijn, I.E., Czarny, B.M.S., Wang, X.Y., Chong, S.Y., Pastorin, G., De Kleijn, D.P.V., Storm, G. & Schiffelers, R.M. (24.08.2016). Liposome-encapsulated berberine treatment reduces adverse ventricle remodeling after myocardial infarction. European Heart Journal, 37, (pp. 919) (1 p.).
Kooijmans, S. A A, Fliervoet, L. A L, Van Der Meel, R., Fens, M. H A M, Heijnen, H. F G, Van Bergen En Henegouwen, P. M P, Vader, P. & Schiffelers, R. M. (28.02.2016). PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time. Journal of Controlled Release, 224, (pp. 77-85) (9 p.).
  2015 - Scholarly publications
Shi, Yang, Van Der Meel, Roy, Theek, Benjamin, Oude Blenke, Erik, Pieters, Ebel H E, Fens, Marcel H A M, Ehling, Josef, Schiffelers, Raymond M., Storm, Gert, Van Nostrum, Cornelus F., Lammers, Twan & Hennink, Wim E. (28.04.2015). Complete regression of xenograft tumors upon targeted delivery of paclitaxel via ∏ - ∏ stacking stabilized polymeric micelles. ACS Nano, 9 (4), (pp. 3740-3752) (13 p.).
Maas, Sybren L N, De Vrij, Jeroen, Van Der Vlist, Els J., Geragousian, Biaina, Van Bloois, Louis, Mastrobattista, Enrico, Schiffelers, Raymond M., Wauben, Marca H M, Broekman, Marike L D & Nolte-'T Hoen, Esther N M (28.02.2015). Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics. Journal of Controlled Release, 200, (pp. 87-96) (10 p.).
  2014 - Scholarly publications
Yousefi, Afrouz, Bourajjaj, Meriem, Babae, Negar, Noort, Paula I Van, Schaapveld, Roel Q J, Beijnum, Judy R Van, Griffioen, Arjan W., Storm, Gert, Schiffelers, Raymond M. & Mastrobattista, Enrico (10.09.2014). Anginex lipoplexes for delivery of anti-angiogenic siRNA. International Journal of Pharmaceutics, 472 (1-2), (pp. 175-184) (10 p.).
Naksuriya, Ornchuma, Okonogi, Siriporn, Schiffelers, Raymond M. & Hennink, Wim E. (01.03.2014). Curcumin nanoformulations - A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. Biomaterials, 35 (10), (pp. 3365-3383) (19 p.).
Kim, Dae-Kyum, Lee, Jaewook, Kim, Sae Rom, Choi, Dong-Sic, Yoon, Yae Jin, Kim, Ji Hyun, Go, Gyeongyun, Nhung, Dinh, Hong, Kahye, Jang, Su Chul, Kim, Si-Hyun, Park, Kyong-Su, Kim, Oh Youn, Park, Hyun Taek, Seo, Ji Hye, Aikawa, Elena, Baj-Krzyworzeka, Monika, van Balkom, Bas W M, Belting, Mattias, Blanc, Lionel, Bond, Vincent, Bongiovanni, Antonella, Borràs, Francesc E, Buée, Luc, Buzás, Edit I, Cheng, Lesley, Clayton, Aled, Cocucci, Emanuele, Dela Cruz, Charles S, Desiderio, Dominic M, Di Vizio, Dolores, Ekström, Karin, Falcon-Perez, Juan M, Gardiner, Chris, Giebel, Bernd, Greening, David W, Gross, Julia Christina, Gupta, Dwijendra, Hendrix, An, Hill, Andrew F, Hill, Michelle M, Nolte-'t Hoen, Esther, Hwang, Do Won, Inal, Jameel, Jagannadham, Medicharla V, Jayachandran, Muthuvel, Jee, Young-Koo, Jørgensen, Malene, Kim, Kwang Pyo, Kim, Yoon-Keun, Kislinger, Thomas, Lässer, Cecilia, Lee, Dong Soo, Lee, Hakmo, van Leeuwen, Johannes, Lener, Thomas, Liu, Ming-Lin, Lötvall, Jan, Marcilla, Antonio, Mathivanan, Suresh, Möller, Andreas, Morhayim, Jess, Mullier, François, Nazarenko, Irina, Nieuwland, Rienk, Nunes, Diana N, Pang, Ken, Park, Jaesung, Patel, Tushar, Pocsfalvi, Gabriella, Del Portillo, Hernando, Putz, Ulrich, Ramirez, Marcel I, Rodrigues, Marcio L, Roh, Tae-Young, Royo, Felix, Sahoo, Susmita, Schiffelers, Raymond, Sharma, Shivani, Siljander, Pia, Simpson, Richard J, Soekmadji, Carolina, Stahl, Philip, Stensballe, Allan, Stępień, Ewa, Tahara, Hidetoshi, Trummer, Arne, Valadi, Hadi, Vella, Laura J, Wai, Sun Nyunt, Witwer, Kenneth, Yáñez-Mó, María, Youn, Hyewon, Zeidler, Reinhard, Gho, Yong Song & Nolte - t Hoen, Esther (10.11.2014). EVpedia - a community web portal for extracellular vesicles research. Bioinformatics © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail:
Yousefi, Afrouz, Lauwers, Marianne, Nemes, Reka, van Holten, Thijs, Babae, Negar, Roest, Mark, Storm, Gert, Schiffelers, Raymond & Mastrobattista, Enrico (20.05.2014). Hemocompatibility Assessment of two siRNA Nanocarrier Formulations. Pharmaceutical Research, 31 (11), (pp. 3127-3135) (9 p.).
Kormelink, Tom Groot, Powe, Desmond G., Kuijpers, Sylvia A., Abudukelimu, Abulikemu, Fens, Marcel H A M, Pieters, Ebel H E, Kassing-Van der Ven, Willemiek W., Habashy, Hany O., Ellis, Ian O., Blokhuis, Bart R., Thio, Marco, Hennink, Wim E., Storm, Gert, Redegeld, Frank A. & Schiffelers, Raymond M. (01.01.2014). Immunoglobulin free light chains are biomarkers of poor prognosis in basal-like breast cancer and are potential targets in tumor-associated inflammation. Oncotarget, 5 (10), (pp. 3159-3167) (9 p.).
van der Aa, L J, Vader, P, Storm, G, Schiffelers, R M & Engbersen, J F J (10.12.2014). Intercalating quaternary nicotinamide-based poly(amido amine)s for gene delivery. Journal of Controlled Release, 195, (pp. 11-20) (10 p.). Copyright © 2014 Elsevier B.V. All rights reserved..
Babae, Negar, Bourajjaj, Meriem, Liu, Yijia, Van Beijnum, Judy R., Cerisoli, Francesco, Scaria, Puthupparampil V., Verheul, Mark, Van Berkel, Maaike P., Pieters, Ebel H E, Van Haastert, Rick J., Yousefi, Afrouz, Mastrobattista, Enrico, Storm, Gert, Berezikov, Eugene, Cuppen, Edwin, Woodle, Martin, Schaapveld, Roel Q J, Prevost, Gregoire P., Griffioen, Arjan W., Van Noort, Paula I. & Schiffelers, Raymond M. (01.01.2014). Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma. Oncotarget, 5 (16), (pp. 6687-6700) (14 p.).
Heukers, Raimond, Altintas, Isil, Raghoenath, Smiriti, De Zan, Erica, Pepermans, Richard, Roovers, Rob C., Haselberg, Rob, Hennink, Wim E., Schiffelers, Raymond M., Kok, Robbert J. & Van Bergen en Henegouwen, Paul M P (01.01.2014). Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles. Biomaterials, 35 (1), (pp. 601-610) (10 p.).
van der Meel, R., Krawczyk-Durka, M., van Solinge, W.W. & Schiffelers, R.M. (2014). Towards routine detection of extracellular vesicles in clinical samples. International Journal of Laboratory Hematology, 36, (pp. 244-253) (10 p.).
  2013 - Scholarly publications
de Vooght, K.M.K., Lau, C., de Laat, P.P., van Wijk, H.A., van Solinge, W.W. & Schiffelers, R.M. (2013). Extracellular vesicles in the circulation: are erythrocyte microvesicles a confounder in the plasma haemoglobin assay?. Biochemical Society Transactions, 41 (1), (pp. 288-92) (5 p.).
van der Meel, Roy, Oliveira, Sabrina, Altintas, Isil, Heukers, Raimond, Pieters, Ebel H E, van Bergen en Henegouwen, Paul M P, Storm, G, Hennink, Wim, Kok, Robbert J & Schiffelers, Raymond M (26.07.2013). Inhibition of tumor growth by targeted anti-EGFR/IGF-1R nanobullets depends on efficient blocking of cell survival pathways. Molecular Pharmaceutics, 10 (10), (pp. 3717-27) (11 p.).
Altintas, I., Heukers, R., van der Meel, R., Lacombe, M., Amidi, M., van Bergen en Henegouwen, P.M.P., Hennink, W.E., Schiffelers, R.M. & Kok, R.J. (2013). Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells. Journal of Controlled Release, 165 (2), (pp. 110-118) (9 p.).
Alaarg, A.M.S.A., Schiffelers, R.M., van Solinge, W.W. & van Wijk, H.A. (2013). Red blood cell vesiculation in hereditary hemolytic anemia. Frontiers in Physiology, 4, (pp. 365) (15 p.).
Oude Blenke, E., Mastrobattista, E. & Schiffelers, R.M. (2013). Strategies for triggered drug release from tumor targeted liposomes. Expert Opinion on Drug Delivery, 10 (10), (pp. 1399-410) (12 p.).
Vader, P., Fens, M.H.A.M., Sachini, N., van Oirschot, B.A., Andringa, G., Egberts, A.C.G., Gaillard, C.A.J.M., Rasmussen, J.T., van Wijk, H.A., van Solinge, W.W. & Schiffelers, R.M. (2013). Taxol((R))-induced phosphatidylserine exposure and microvesicle formation in red blood cells is mediated by its vehicle Cremophor((R)) EL. Nanomedicine, 8 (7), (pp. 1127-1135) (9 p.).
Yousefi, A., Storm, G., Schiffelers, R.M. & Mastrobattista, E. (2013). Trends in polymeric delivery of nucleic acids to tumors. Journal of Controlled Release, 170 (2), (pp. 209-18) (10 p.).
  2012 - Scholarly publications
Fens, M.H.A.M., van Wijk, H.A., Andringa, G., van Rooijen, K.L., Dijstelbloem, H.M., Rasmussen, J.T., de Vooght, K.M.K., Schiffelers, R.M., Gaillard, C.A. & van Solinge, W.W. (2012). A role for activated endothelial cells in red blood cell clearance: implications for vasopathology. Haematologica, 97 (4), (pp. 500-8) (9 p.).
Coimbra, M., Rijcken, C.J.F., Stigter, M., Hennink, W.E., Storm, G. & Schiffelers, R.M. (2012). Antitumor efficacy of dexamethasone-loaded core-crosslinked polymeric micelles. Journal of Controlled Release, 163 (3), (pp. 361-7) (7 p.).
van Rooy, I., Hennink, W.E., Storm, G., Schiffelers, R.M. & Mastrobattista, E. (2012). Attaching the phage display-selected GLA peptide to liposomes: factors influencing target binding. European Journal of Pharmaceutical Sciences, 45 (3), (pp. 330-5) (6 p.).
Coimbra, M., Crielaard, B.J., Storm, G. & Schiffelers, R.M. (2012). Critical factors in the development of tumor-targeted anti-inflammatory nanomedicines. Journal of Controlled Release, 160 (2), (pp. 232-8) (7 p.).
Crielaard, B.J., Lammers, T., Schiffelers, R.M. & Storm, G. (2012). Drug targeting systems for inflammatory disease: one for all, all for one. Journal of Controlled Release, 161 (2), (pp. 225-34) (10 p.).
Kooijmans, S.A.A., Vader, P., van Dommelen, S.M., van Solinge, W.W. & Schiffelers, R.M. (2012). Exosome mimetics: a novel class of drug delivery systems. International Journal of Nanomedicine, 7, (pp. 1525-41) (17 p.).
Crielaard, B.J., Rijcken, C.J.F., Quan, L., van der Wal, S., Altintas, I., van der Pot, M., Kruijtzer, J.A.W., Liskamp, R.M.J., Schiffelers, R.M., van Nostrum, C.F., Hennink, W.E., Wang, D., Lammers, T.G.G.M. & Storm, G. (2012). Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angewandte Chemie-International Edition, 29, (pp. 7254-7258) (5 p.).
Crielaard, B.J., van der Wal, S., Le, H.T., Bode, A.T., Lammers, T., Hennink, W.E., Schiffelers, R.M., Fens, M.H.A.M. & Storm, G. (2012). Liposomes as carriers for colchicine-derived prodrugs: vascular disrupting nanomedicines with tailorable drug release kinetics. European Journal of Pharmaceutical Sciences, 45 (4), (pp. 429-35) (7 p.).
van Dommelen, S.M., Vader, P., Lakhal, S., Kooijmans, S.A.A., van Solinge, W.W., Wood, M.J.A. & Schiffelers, R.M. (2012). Microvesicles and exosomes: opportunities for cell-derived membrane vesicles in drug delivery. Journal of Controlled Release, 161 (2), (pp. 635-644) (10 p.).
te Boekhorst, B.C.M., Jensen, L.B., Colombo, S., Varkouhi, A.K., Schiffelers, R.M., Lammers, T., Storm, G., Nielsen, H.M., Strijkers, G.J., Foged, C. & Nicolay, K. (2012). MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model. Journal of Controlled Release, 161 (3), (pp. 772-80) (9 p.).
Altintas, I., Heukers, R., van der Meel, R., Lacombe, M., Amidi, M., van Bergen en Henegouwen, P.M.P., Hennink, W.E., Schiffelers, R.M. & Kok, R.J. (2012). Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells. Cell Biology International, 165 (2), (pp. 110-118) (9 p.).
Vader, P., Aa, L.J., Engbersen, J.F.J., Storm, G. & Schiffelers, R.M. (2012). Physicochemical and biological evaluation of siRNA polyplexes based on PEGylated Poly(amido amine)s. Pharmaceutical Research, 29 (2), (pp. 352-61) (10 p.).
Vader, P., Aa, L.J., Storm, G., Schiffelers, R.M. & Engbersen, J.F.J. (2012). Polymeric carrier systems for siRNA delivery. Current Topics in Medicinal Chemistry, 12 (2), (pp. 108-19) (12 p.).
Varkouhi, A.K., Mountrichas, G., Schiffelers, R.M., Lammers, T., Storm, G., Pispas, S. & Hennink, W.E. (2012). Polyplexes based on cationic polymers with strong nucleic acid binding properties. European Journal of Pharmaceutical Sciences, 45 (4), (pp. 459-66) (8 p.).
Vader, P., Crielaard, B.J., van Dommelen, S.M., Meel, R., Storm, G. & Schiffelers, R.M. (2012). Targeted delivery of small interfering RNA to angiogenic endothelial cells with liposome-polycation-DNA particles. Journal of Controlled Release, 160 (2), (pp. 211-6) (6 p.).
Altintas, I., Kok, R.J. & Schiffelers, R.M. (2012). Targeting epidermal growth factor receptor in tumors: from conventional monoclonal antibodies via heavy chain-only antibodies to nanobodies. European Journal of Pharmaceutical Sciences, 45 (4), (pp. 399-407) (9 p.).
Van Der Meel, R., Oliveira, S., Altintas, I., Haselberg, R., Roovers, R.C., Van Bergen en Henegouwen, P.M.P., Hennink, W.E., Storm, G, Schiffelers, R.M. & Kok, R.J. (01.11.2012). Tumor-targeted nanobullets for anti-cancer combination therapy. European Journal of Cancer, 48, (pp. 38) (1 p.).
van der Meel, R., Oliveira, S., Altintas, I., Haselberg, R., van der Veeken, J., Roovers, R.C., van Bergen en Henegouwen, P.M.P., Storm, G., Hennink, W.E., Schiffelers, R.M. & Kok, R.J. (2012). Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment. Journal of Controlled Release, 159 (2), (pp. 281-9) (9 p.).
Kalra, H., Simpson, R.J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V.C., Borras, F.E., Breakefield, X., Budnik, V., Buzas, E., Camussi, G., Clayton, A., Cocucci, E., Falcon-Perez, J.M., Gabrielsson, S., Gho, Y.S., Gupta, D., Harsha, H.C., Hendrix, A., Hill, A.F., Inal, J.M., Jenster, G., Kramer-Albers, E.M., Lim, S.K., Llorente, A., Lotvall, J., Marcilla, A., Mincheva-Nilsson, L., Nazarenko, I., Nieuwland, R., Nolte-'t Hoen, E.N.M., Pandey, A, Patel, T., Piper, M.G., Pluchino, S., Prasad, T.S., Rajendran, L., Raposo, G., Record, M., Reid, G.E., Sanchez-Madrid, F., Schiffelers, R.M., Siljander, P., Stensballe, A., Stoorvogel, W., Taylor, D., Thery, C., Valadi, H., van Balkom, B.W.M., Vazquez, J., Vidal, M., Wauben, M.H.M., Yanez-Mo, M., Zoeller, M. & Mathivanan, S. (2012). Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biology, 10 (12), (pp. 10.1371/ journal.pbio.1001450) (1 p.).
  2011 - Scholarly publications
Crielaard, B.J., van der Wal, S., Lammers, T., Le, H.T., Hennink, W.E., Schiffelers, R.M., Storm, G. & Fens, M.H.A.M. (2011). A polymeric colchicinoid prodrug with reduced toxicity and improved efficacy for vascular disruption in cancer therapy. International Journal of Nanomedicine, 6, (pp. 2697-703) (7 p.).
Kluza, E., Yeo, S.Y., Schmid, S., van der Schaft, D.W., Boekhoven, R.W., Schiffelers, R.M., Storm, G., Strijkers, G.J. & Nicolay, K. (2011). Anti-tumor activity of liposomal glucocorticoids: The relevance of liposome-mediated drug delivery, intratumoral localization and systemic activity. Journal of Controlled Release, 151 (1), (pp. 10-7) (8 p.).
Mullauer, F.B., van Bloois, L., Daalhuisen, J.B., Brink, M.S., Storm, G., Medema, J.P., Schiffelers, R.M. & Kessler, J.H. (2011). Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity. Anti-Cancer Drugs, 22 (3), (pp. 223-33) (11 p.).
Lee, J.S., Ankone, M., Pieters, E., Schiffelers, R.M., Hennink, W.E. & Feijen, J. (2011). Circulation kinetics and biodistribution of dual-labeled polymersomes with modulated surface charge in tumor-bearing mice: comparison with stealth liposomes. Journal of Controlled Release, 155 (2), (pp. 282-8) (7 p.).
van Rooy, I., Mastrobattista, E., Storm, G., Hennink, W.E. & Schiffelers, R.M. (2011). Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain. Journal of Controlled Release, 150, (pp. 30-36) (7 p.).
Vader, P., Aa, L.J., Engbersen, J.F.J., Storm, G. & Schiffelers, R.M. (2011). Disulfide-based poly(amido amine)s for siRNA delivery: effects of structure on siRNA complexation, cellular uptake, gene silencing and toxicity. Pharmaceutical Research, 28 (5), (pp. 1013-22) (10 p.).
Vader, P., van der Meel, R., Symons, M.H., Fens, M.H.A.M., Pieters, E.H.E., Wilschut, K.J., Storm, G., Jarzabek, M., Gallagher, W.M., Schiffelers, R.M. & Byrne, A.T. (2011). Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach. Angiogenesis, 14, (pp. 457-466) (10 p.).
Varkouhi, A.K., Lammers, T., Schiffelers, R.M., van Steenbergen, M.J., Hennink, W.E. & Storm, G. (2011). Gene silencing activity of siRNA polyplexes based on biodegradable polymers. European Journal of Pharmaceutics and Biopharmaceutics, 77 (3), (pp. 450-7) (8 p.).
Gomes Coimbra, M.J., Isacchi, B., van Bloois, L., Sastre Torano, J., Ket, A., Wu, X., Broere, F., Metselaar, J.M., Rijcken, C.J.F., Storm, G., Bilia, R. & Schiffelers, R.M. (2011). Improving solubitity and chemical stability of natural compounds for medicinal use by incorporation into liposomes. International Journal of Pharmaceutics, 416, (pp. 433-442) (10 p.).
van Rooy, I., Cakir-Tascioglu, S., Hennink, W.E., Storm, G., Schiffelers, R.M. & Mastrobattista, E. (2011). In vivo methods to study uptake of nanoparticles into the brain. Pharmaceutical Research, 28 (3), (pp. 456-71) (16 p.).
Kluza, E., Heisen, M., Schmid, S., van der Schaft, D.W., Schiffelers, R.M., Storm, G., ter Haar Romeny, B.M., Strijkers, G.J. & Nicolay, K. (2011). Multi-parametric assessment of the anti-angiogenic effects of liposomal glucocorticoids. Angiogenesis, 14 (2), (pp. 143-53) (11 p.).
Schiffelers, R.M., van der Vaart, T.K. & Storm, G. (2011). Neovascular age-related macular degeneration: opportunities for development of first-in-class biopharmaceuticals. BioDrugs, 25 (3), (pp. 171-89) (19 p.).
Aa, L.J., Vader, P., Storm, G., Schiffelers, R.M. & Engbersen, J.F.J. (2011). Optimization of poly(amido amine)s as vectors for siRNA delivery. Journal of Controlled Release, 150 (2), (pp. 177-86) (10 p.).
van Rooy, I., Wu, S.Y., Storm, G., Hennink, W.E., Dinter-Heidorn, H., Schiffelers, R.M. & Mastrobattista, E. (2011). Preparation and characterization of liposomal formulations of neurotensin-degrading enzyme inhibitors. International Journal of Pharmaceutics, 416 (2), (pp. 448-52) (5 p.).
Varkouhi, A.K., Foillard, S., Lammers, T., Schiffelers, R.M., Doris, E., Hennink, W.E. & Storm, G. (2011). SiRNA delivery with functionalized carbon nanotubes. International Journal of Pharmaceutics, 416 (2), (pp. 419-25) (7 p.).
Altintas, I., Schiffelers, R.M. & Kok, R.J. (2011). Targeted delivery of kinase inhibitors: a nanomedicine approach for improved selectivity in cancer. Current Signal Transduction Therapy, 6, (pp. 267-278) (12 p.).
van der Meel, R., Symons, M.H., Kudernatsch, R., Kok, R.J., Schiffelers, R.M., Storm, G., Gallagher, W.M. & Byrne, A.T. (2011). The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy. Drug Discovery Today, 16 (5-6), (pp. 219-28) (10 p.).
  2010 - Scholarly publications
Vader, P., Aa, L.J., Engbersen, J.F.J., Storm, G. & Schiffelers, R.M. (2010). A method for quantifying cellular uptake of fluorescently labeled siRNA. Journal of Controlled Release, 148, (pp. 106-109) (4 p.).
Talelli, M., Iman, M., Varkouhi, A.K., Rijcken, C.J.F., Schiffelers, R.M., Etrych, T., Ulbrich, K., van Nostrum, C.F., Lammers, T., Storm, G. & Hennink, W.E. (2010). Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin. Biomaterials, 31 (30), (pp. 7797-804) (8 p.).
Oliveira, S., Schiffelers, R.M., van der Veeken, J., van der Meel, R., Vongpromek, R., van Bergen en Henegouwen, P.M.P., Storm, G. & Roovers, R.C. (2010). Downregulation of EGFR by a novel multivalent nanobody-liposome platform. Journal of Controlled Release, 145 (2), (pp. 165-175) (11 p.).
Fens, M.H.A.M., Storm, G., Pelgrim, R.C., Ultee, A., Byrne, A.T., Gaillard, C.A.J.M., van Solinge, W.W. & Schiffelers, R.M. (2010). Erythrophagocytosis by angiogenic endothelial cells is enhanced by loss of erythrocyte deformability. Experimental Hematology, 38 (4), (pp. 282-291) (10 p.).
Varkouhi, A.K., Verheul, R.J., Schiffelers, R.M., Lammers, T.G.G.M., Storm, G. & Hennink, W.E. (2010). Gene silencing activity of siRNA polyplexes based on thiolated N,N,N-trimethylated chitosan. Bioconjugate Chemistry, 21, (pp. 2339-2346) (8 p.).
van Rooy, I., Cakir-Tascioglu, S., Couraud, P.O., Romero, I.A., Weksler, B., Storm, G., Hennink, W.E., Schiffelers, R.M. & Mastrobattista, E. (2010). Identification of peptide ligands for targeting to the blood-brain barrier. Pharmaceutical Research, 27 (4), (pp. 673-82) (10 p.).
Gomes Coimbra, M.J., Banciu, M., Fens, M.H.A.M., de Smet, L., Cabaj, M., Metselaar, J.M., Storm, G. & Schiffelers, R.M. (2010). Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation. Journal of Controlled Release, 148 (3), (pp. 303-10) (8 p.).
Kuijpers, S.A., Gomes Coimbra, M.J., Storm, G. & Schiffelers, R.M. (2010). Liposomes targeting tumour stromal cells. Molecular Membrane Biology, 27 (7), (pp. 328-40) (13 p.).
Lobatto, M.E., Fayad, Z.A., Silvera, S., Vucic, E., Calcagno, C., Mani, V., Dickson, S.D., Nicolay, K., Banciu, M., Schiffelers, R.M., Metselaar, J.M., van Bloois, L., Wu, H.S., Fallon, J.T., Rudd, J.H., Fuster, V., Fisher, E.A., Storm, G. & Mulder, W.J.M. (2010). Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis. Molecular Pharmaceutics, 7 (6), (pp. 2020-9) (10 p.).
van der Meel, R., Gallagher, W.M., Oliveira, S., O'Connor, A.E., Schiffelers, R.M. & Byrne, A.T. (2010). Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies. Drug Discovery Today, 15 (3-4), (pp. 102-14) (13 p.).
Fens, M.H.A.M., Storm, G. & Schiffelers, R.M. (2010). Tumor vasculature as target for therapeutic intervention. Expert Opinion on Investigational Drugs, 19 (11), (pp. 1321-38) (18 p.).
  2009 - Scholarly publications
van der Veeken, J., Oliveira, S., Schiffelers, R.M., Storm, G., Henegouwen, P. & Roovers, R.C. (2009). Crosstalk Between Epidermal Growth Factor Receptor- and Insulin-Like Growth Factor-1 Receptor Signaling: Implications for Cancer Therapy. Current Cancer Drug Targets, 9 (6), (pp. 748-760) (13 p.). ISI:000271379500005.
Schiffelers, R.M. & de Visser, K.E. (2009). Inflammation as Target for Pharmaceutical Intervention in Cancer. Current Pharmaceutical Design, 15 (16), (pp. 1822-1824) (3 p.). ISI:000266567000001.
Gomes Coimbra, M.J., Kuijpers, S.A., van Seters, S.P., Storm, G. & Schiffelers, R.M. (2009). Targeted Delivery of Anti-Inflammatory Agents to Tumors. Current Pharmaceutical Design, 15 (16), (pp. 1825-1843) (19 p.). ISI:000266567000002.
  2008 - Scholarly publications
Fens, M.H.A.M., Mastrobattista, E., de Graaff, A.M., Flesch, F.M., Ultee, A., Rasmussen, J., Molema, G., Storm, G. & Schiffelers, R.M. (2008). Angiogenic dndothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells. Blood, 111 (9), (pp. 4542-4550) (9 p.).
Banciu, M., Fens, M.H.A.M., Storm, G. & Schiffelers, R.M. (2008). Antitumor activity and tumor localization of liposomal glucocorticoids in B16 melanoma-bearing mice. Journal of Controlled Release, 127, (pp. 131-136) (6 p.).
Banciu, M., Metselaar, J.M., Schiffelers, R.M. & Storm, G. (2008). Antitumor activity of liposomal prednisolone phosphate depends on the presence of functional tumor-associated macrophages in tumor tissue. Neoplasia, 10, (pp. 108-117) (10 p.).
Oliveira, S., Høgset, A, Storm, G & Schiffelers, R M (2008). Delivery of siRNA to the target cell cytoplasm - photochemical internalization facilitates endosomal escape and improves silencing efficiency, in vitro and in vivo. Current Pharmaceutical Design, 14 (34), (pp. 3686-97) (12 p.).
Banciu, M., Schiffelers, R.M. & Storm, G. (2008). Investigation into the role of tumor-associated macrophages in the antitumor activity of doxil. Pharmaceutical Research, 25, (pp. 1948-1955) (8 p.).
Fens, M.H.A.M., Hill, K.J., Ashton, S.E., Westwood, F.R., Blakey, D.C., Storm, G. & Schiffelers, R.M. (2008). Liposomal encapsulation enhances the antitumour efficacy of the vascular disrupting agent ZD6126 in murine B16.F10 melanoma. British Journal of Cancer, 99, (pp. 1256-1264) (9 p.).
Banciu, M., Metselaar, J.M., Schiffelers, R.M. & Storm, G. (2008). Liposomal glucocorticoids as tumor-targeted anti-angiogenic nanomedicine in B16 melanoma-bearing mice. Journal of Steroid Biochemistry and Molecular Biology, 111, (pp. 101-110) (10 p.).
Schiffelers, R.M. & Storm, G. (2008). Liposomal nanomedicines as anticancer therapeutics: Beyond targeting tumor cells. International Journal of Pharmaceutics, 364, (pp. 258-264) (7 p.).
Banciu, M., Schiffelers, R.M., Metselaar, J.M. & Storm, G. (2008). Utility of targeted glucocorticoids in cancer therapy. Journal of Liposome Research, 18, (pp. 47-57) (11 p.).
  2007 - Scholarly publications
Mastrobattista, E., Hennink, W.E. & Schiffelers, R.M. (2007). Delivery of nucleic acids. Pharmaceutical Research, 24, (pp. 1561-1563) (3 p.).
de Wolf, H.K., Snel, C.J., Verbaan, F.J., Schiffelers, R.M., Hennink, W.E. & Storm, G. (2007). Effect of cationic carriers on the pharmacokinetics and tumor localization of nucleic acids after intravenous administration. International Journal of Pharmaceutics, 331, (pp. 167-170) (4 p.).
Schiffelers, R.M., Blaauboer, B.J., Fentener van Vlissingen, J.M., Kuil, J., Remie, R., Vaal, M.A. & Hendriksen, C.F.M. (2007). Factors Stimulating or Obstructing the Implementation of the 3Rs in the Regulatory Process. ALTEX-Alternatives to Animal Experimentation, 24 (4), (pp. 271-278) (8 p.).
Oliveira, S., van Rooy, Inge, Kranenburg, Onno, Storm, G & Schiffelers, Raymond (2007). Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes. International Journal of Pharmaceutics, 331 (2), (pp. 211-4) (4 p.).
Rijcken, C.J.F., Snel, C.J., Schiffelers, R.M., van Nostrum, C.F. & Hennink, W.E. (2007). Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies. Biomaterials, 28, (pp. 5581-5593) (13 p.).
Oliveira, S., Fretz, M.M., Hogest, A., Storm, G. & Schiffelers, R.M. (2007). Photochemical internalization enhances silencing of epidermal growth factor receptor through improved endosomal escape of SiRNA. Biochimica et Biophysica Acta - Biomembranes, 1768, (pp. 1211-1217) (7 p.).
Schiffelers, R.M., de Wolf, H.K., van Rooy, I. & Storm, G. (2007). Synthetic delivery systems for intravenous administration of nucleic acids. Nanomedicine, 2 (2), (pp. 169-181) (13 p.).
Steenwinkel, J.E., van Vianen, W., ten Kate, M.T., Verburg, H., Agtmael, M.A., Schiffelers, R.M. & Bakker-Woudenberg, I.A. (2007). Targeted drug delivery to enhance efficacy and shorten treatment duration in disseminated Mycobacterium avium-infection in mice. Journal of Antimicrobial Chemotherapy, 60, (pp. 1064-2007) (944 p.).
Schiffelers, R.M., Fens, M.H.A.M., van Blijswijk, J.M., Bink, D.I. & Storm, G. (2007). Targeting the retinal microcirculation to treat diabetic sight problems. Expert Opinion on Therapeutic Targets, 11, (pp. 1493-1502) (10 p.).
  2007 - Professional publications
Schiffelers, R.M. & Mastrobattista, E. (2007). Oligonucleotides. In D.J.A. Crommelin, R.D. Sindelar & B. Meibohm (Eds.), Pharmaceutical Biotechnology, An Introduction for Pharmacists and Pharmaceutical Scientists (pp. 211-223) (13 p.). New York/London: Informa Healthcare.
  2006 - Scholarly publications
Banciu, M., Schiffelers, R.M., Fens, M.H.A.M., Metselaar, J.M. & Storm, G. (2006). Anti-angiogenic effects of liposomal prednisolone phosphate on B16 melanoma in mice. Journal of Controlled Release, 113, (pp. 1-8) (8 p.).
Schiffelers, R.M. & Storm, G. (2006). ICS-283: a system for targeted intravenous delivery of siRNA. Expert Opinion on Drug Delivery, 3, (pp. 445-454) (10 p.).
Oliveira, S., van Bergen en Henegouwen, P.M.P., Storm, G. & Schiffelers, R.M. (2006). Molecular biology of epidermal growth factor receptor inhibition for cancer therapy. Expert Opinion on Biological Therapy, 6, (pp. 605-617) (13 p.).
Oliveira, S., Storm, G. & Schiffelers, R.M. (2006). Targeted delivery of siRNA. Journal of Biomedicine and Biotechnology, 4, (pp. 1-9) (9 p.).
Koning, G.A., Schiffelers, R.M., Wauben, M.H.M., Kok, R.J., Mastrobattista, E., Molema, G., ten Hagen, T.L.M. & Storm, G. (2006). Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis. Arthritis and Rheumatism, 54, (pp. 1198-1208) (11 p.).
Schiffelers, R.M., Banciu, M., Metselaar, J.M. & Storm, G. (2006). Therapeutic application of long-circulating liposomal glucocorticoids in auto-immune diseases and cancer. Journal of Liposome Research, 16, (pp. 186-194) (9 p.).
  2006 - Professional publications
Schiffelers, R.M., Storm, G. & Bakker-Woudenberg, I.A. (2006). Chapter 29: Pharmaceutical nanocarriers in treatment and imaging of infection. In V. Torchilin (Eds.), Nanoparticulates (pp. 697-711) (15 p.). London, UK: Imperial College Press.
Schiffelers, R.M., Crommelin, D.J.A. & Storm, G. (2006). Chapter 7: Silencing proteins. In V. Torchilin (Eds.), Delivery of Protein and Peptide Drugs in Cancer (pp. 127-143) (17 p.). London, UK: Imperial College Press.
Schiffelers, R.M., Gjini, E., Fens, M.H.A.M., Janssen, A.P.C.A. & Storm, G. (2006). Liposomal Targeting of angiogenic tumor vasculature. In G. Gregoriadis (Eds.), Volume III: Interactions of Liposomes with the Biological Milieu (pp. 211-222) (12 p.).
  2005 - Scholarly publications
Schiffelers, R.M., Xu, J., Storm, G., Woodle, M.C. & Scaria, P.V. (2005). Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis. Arthritis and Rheumatism, 52 (4), (pp. 1314-1318) (5 p.).
Schiffelers, R.M., Fens, M.H.A.M., Janssen, A.P.C.A., Molema, G. & Storm, G. (2005). Liposomal targeting of angiogenic vasculature. Current Drug Delivery, 2, (pp. 363-368) (6 p.).
Schiffelers, R.M., Metselaar, J.M., Fens, M., Janssen, A., Molema, G. & Storm, G. (2005). Liposome-encapsulated prednisolone phosphate inhibits growth of established tumors in mice. Neoplasia, 7 (2), (pp. 118-127) (10 p.).
Temming, K., Schiffelers, R.M., Molema, G. & Kok, R.J. (2005). RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature. Drug Resistance Updates, 8, (pp. 3435-367) (69 p.).
Schiffelers, R.M., van Kolfschoten, S.C., van Dijk, M., Scaria, P.V., Woodle, M.C. & Storm, G. (2005). siRNA as a new drug: intellectual property. Expert Opinion on Therapeutic Patents, 15 (2), (pp. 141-152) (12 p.).
Schiffelers, R.M., van Rooy, I. & Storm, G. (2005). siRNA-mediated inhibition of angiogenesis. Expert Opinion on Biological Therapy, 5 (3), (pp. 359-368) (10 p.).
Soga, O., van Nostrum, C.F., Fens, M., Rijcken, C.J.F., Schiffelers, R.M., Storm, G. & Hennink, W.E. (2005). Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery. Journal of Controlled Release, 103 (2), (pp. 341-353) (13 p.).
Schiffelers, R.M., Mixson, A.J., Ansari, A.M., Fens, M.H.A.M., Tang, Q., Zhou, Q., Xu, J., Molema, G., Lu, P.Y., Scaria, P.V., Storm, G. & Woodle, M.C. (2005). Transporting silence: Design of carriers for siRNA to angiogenic endothelium. Journal of Controlled Release, 109, (pp. 4-14) (11 p.).
  2005 - Professional publications
Bakker-Woudenberg, I.A., Schiffelers, R.M., Storm, G., Becker, M.J. & Guo, L. (2005). Long-circulating sterically stabilized liposomes in the treatment of infections. In G.S. Kwon (Eds.), Polymeric Drug Delivery Systems (36 p.). Boca Raton, Fl.: Taylor & Francis.
  2004 - Scholarly publications
Schiffelers, R.M., Ansari, A.M., Xu, J., Zhou, Q., Tang, Q., Storm, G., Molema, G., Lu, P.Y., Scaria, P.V. & Woodle, M.C. (2004). Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Research, 32, (pp. 149) (1 p.).
Kim, B., Tang, Q., Biswas, P.S., Xu, J., Schiffelers, R.M., Xie, F.Y., Ansari, A.M., Scaria, P.V., Woodle, M.C., Lu, P. & Rouse, B.T. (2004). Inhibition of ocular aniogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. American Journal of Pathology, 165, (pp. 2177-2185) (9 p.).
Schiffelers, R.M., Woodle, M.C. & Scaria, P. (2004). Pharmaceutical prospects for RNA interference. Pharmaceutical Research, 21, (pp. 1-7) (7 p.).
  2003 - Scholarly publications
Schiffelers, R.M., Koning, G.A., ten Hagen, T.L.M., Fens, M.H.A.M., Schraa, A.J., Janssen, A.P.C.A., Kok, R.J., Molema, G. & Storm, G. (2003). Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin. Journal of Controlled Release, 91, (pp. 115-122) (8 p.).
Schiffelers, R.M. & Bakker-Woudenberg, I.A. (2003). Innovations in liposomal formulations for antimicrobial therapy. Expert Opinion on Therapeutic Patents, 13, (pp. 1127-1140) (14 p.).
Janssen, A.P.C.A., Schiffelers, R.M., ten Hagen, T.L.M., Koning, G.A., Schraa, A.J., Kok, R.J., Storm, G. & Molema, G. (2003). Peptide-targeted PEG-liposomes in anti-angiogenic therapy. International Journal of Pharmaceutics, 254, (pp. 55-58) (4 p.).
  2002 - Scholarly publications
Stearne-Cullen, L.E.T., Schiffelers, R.M., Smouter, E., Bakker-Woudenberg, I.A. & Gyssens, I.C. (2002). Biodistribution of long-circulation PEG-liposomes in a murine model of established subcutaneous abscesses. Biochimica et Biophysica Acta, 1561, (pp. 91-97) (7 p.).
Schiffelers, R.M., Molema, G., ten Hagen, T.L.M., Janssen, A.P.C.A., Schraa, A.J., Kok, R.J., Koning, G.A. & Storm, G. (2002). Ligand-targeted liposome directed against pathological vasculature. Journal of Liposome Research, 12, (pp. 129-135) (7 p.).
Schiffelers, R.M., Storm, G., ten Kate, M.T., Stearne-Cullen, L.E.T., den Hollander, J.G., Verburgh, H.A. & Bakker-Woudenberg, I.A. (2002). Liposome-enabled synergistis interaction of anitmicrobial agents. Journal of Liposome Research, 12, (pp. 121-127) (7 p.).
  2002 - Professional publications
Koning, G.A., Wauben, M.H.M., ten Hagen, T.L.M., Everts, M., Kok, R.J., Schraa, A.J., Molema, G., Schiffelers, R.M. & Storm, G. (2002). Liposomes for drug targeting to endothelial cells at inflammatory sites. Endothelium: Journal of Endothelial Cell Research, 9, (pp. 129-127) (3 p.).
Schiffelers, R.M., Molema, G., ten Hagen, T.L.M., Janssen, A.P.C.A., Schraa, A.J., Kok, R.J., Koning, G.A. & Storm, G. (2002). Targeting of liposomes to angiogenic endothelial cells. Cellular and Molecular Biology Letters, 7, (pp. 255) (1 p.).
  2001 - Scholarly publications
Schiffelers, R.M., Storm, G. & Bakker-Woudenberg, I.A. (2001). Host influencing the preferential localization of sterically stabilized liposomes in Klebsiella pneumoniae-infected rat lung tissue. Pharmaceutical Research, 18, (pp. 780-787) (8 p.).
Schiffelers, R.M., Storm, G., ten Kate, M.T., Stearne-Cullen, L.E.T., den Hollander, J.G., Verburgh, H.A. & Bakker-Woudenberg, I.A. (2001). In vivo synergistic interaction of liposome-coencapsulated gentamicin and ceftazidime. Journal of Pharmacology and Experimental Therapeutics, 298, (pp. 369-375) (7 p.).
Schiffelers, R.M., Storm, G. & Bakker-Woudenberg, I.A. (2001). Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies. Antimicrobial Agents and Chemotherapy, 48, (pp. 333-344) (12 p.).
Schiffelers, R.M., Storm, G. & Bakker-Woudenberg, I.A. (2001). Therapeutic efficacy of liposomal gentamicin in clinically relevant rat models. International Journal of Pharmaceutics, 214, (pp. 103-105) (3 p.).
Schiffelers, R.M., Storm, G., ten Kate, M.T. & Bakker-Woudenberg, I.A. (2001). Therapeutic efficacy of liposome-encapsulated gentamicin in rat Klebsiella pneumoniae in relation to impaired host defense and low bacterial susceptibility to gentamicin. Antimicrobial Agents and Chemotherapy, 45, (pp. 464-470) (7 p.).
  2000 - Scholarly publications
Schiffelers, R.M., Bakker-Woudenberg, I.A. & Storm, G. (2000). Localization of sterically stabilized liposomes in experimental rat Klebsiella pneumonia: dependence on circulation kinetics and presence of poly(ethylene)glycol coating. Biochimica et Biophysica Acta, 1468, (pp. 253-261) (9 p.).
Bakker-Woudenberg, I.A., Schiffelers, R.M., ten Kate, M.T., Storm, G., Guo, L., Working, P.K. & Mouton, J.W. (2000). Targeting of intibodies in bacterial infections usig PEGylated long-cirulating liposomes. Journal of Liposome Research, (pp. 513-521) (9 p.).
  1999 - Scholarly publications
Schiffelers, R.M., Bakker-Woudenberg, I.A., Snijders, S.V. & Storm, G. (1999). Localization of sterically stabilized liposomes in klebsiella pneumoniae-infected rat lung tissue: influence of liposome characteristics. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1421, (pp. 329-339) (11 p.).
  1998 - Scholarly publications
Schiffelers, R.M., Storm, G. & Bakker-Woudenberg, I.A. (1998). Targeting of antibiotics to bacterial infections using long-circulating liposomes. In J.E. Diederichs & R.H. Muller (Eds.), Future Strategies for Drug Delivery with Particulate Systems (pp. 167-171) (5 p.). Stuttgart, Germany: CRC Press Medpharm. GmbH. Scient. Publ..
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Gegenereerd op 2018-01-23 23:07:18
Additional functions and activities

Associate Editor Journal of Extracellular Vesicles

Associate Editor Pharmaceutical Research

Founder/Share holder (<5%)/Scientific Advisor Excytex bv

Member Scientific Advisory Board 20MED Therapeutics

Gegenereerd op 2018-01-23 23:07:18
Full name
prof. dr. R.M. Schiffelers Contact details
Universitair Medisch Centrum Utrecht

Heidelberglaan 100
Room G03.645
The Netherlands

Phone number (direct) +31 6 11 619 197
Mobile phone +31 6 37 610 587
Gegenereerd op 2018-01-23 23:07:18
Last updated 21.08.2017