In the group of Prof Rob Liskamp, Chemistry is applied as a powerful “enabling” science in Chemical Biology facilitating developments in biology and the medical sciences. Core to chemistry is the design and creation of molecules allowing us to obtain insights in biological processes including diseases such as cancer, infections, and autoimmune diseases leading to new approaches of treatment. It requires a multidisciplinary effort where chemical biologists, cancer researchers, physicists, and structural chemists are collaborating. Despite enormous advances, vaccines for malaria, HIV, and hepatitis C are still not available while resistance against antibiotics is increasing. We are developing chemosynthetic vaccines based on essential parts of proteins of a virus. Using molecular evolutionary approaches, we are developing a new generation of smaller (synthetic) antibodies for treatment of inflammation, infections, and cancer.