Key Publications
Pertici, F., de Mol, N. J., Kemmink, J., & Pieters, R. J. (2013). Optimizing bivalent inhibitors of Pseudomonas aeruginosa lectin LecA using a rigid spacer. Chemistry-A European Journal, 19, 16923-16927.
Wittmann, V., & Pieters, R. J. (2013). Bridging lecting binding sites by my multivalent carbohydrates. Chemical Society Reviews, 42(10), 4492-4503. https://doi.org/10.1039/c3cs60089k
Visini, R., Jin, X., Bergmann, M., Michaud, G., Pertici, F., Fu, O., Pukin, A., Branson, T. R., Thies-Weesie, D. M. E., Kemmink, J., Gillon, E., Imberty, A., Stocker, A., Darbre, T., Pieters, R. J., & Reymond, J. L. (2015). Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeruginosa Lectin LecA. ACS Chemical Biology, 10(11), 2455-2462. https://doi.org/10.1021/acschembio.5b00302
Zomer-Van Ommen, D. D., Pukin, A. V., Fu, O., Quarles Van Ufford, L. H. C., Janssens, H. M., Beekman, J. M., & Pieters, R. J. (2016). Functional characterization of cholera toxin inhibitors using human intestinal organoids. Journal of Medicinal Chemistry, 59(14), 6968-6972. https://doi.org/10.1021/acs.jmedchem.6b00770
Zhang, H., Laaf, D., Elling, L., & Pieters, R. J. (2018). Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors. Bioconjugate Chemistry, 29(4), 1266-1275. https://doi.org/10.1021/acs.bioconjchem.8b00047
Haksar, D., de Poel, E., Quarles van Ufford, L. H. C., Bhatia, S., Haag, R., Beekman, J. M., & Pieters, R. J. (2019). Strong inhibition of cholera toxin B subunit by affordable, polymer-based multivalent inhibitors. Bioconjugate Chemistry, 30(3), 785-792. https://doi.org/10.1021/acs.bioconjchem.8b00902
Yu, G., Vicini, A. C., & Pieters, R. J. (2019). Assembly of Divalent Ligands and Their Effect on Divalent Binding to Pseudomonas aeruginosa Lectin LecA. Journal of Organic Chemistry, 84(5), 2470-2488. https://doi.org/10.1021/acs.joc.8b02727
Steigenberger, B., Pieters, R. J., Heck, A. J. R., & Scheltema, R. A. (2019). PhoX: An IMAC-Enrichable Cross-Linking Reagent. ACS Central Science, 5(9), 1514-1522. https://doi.org/10.1021/acscentsci.9b00416
Lu, W., Du, W., Somovilla, V. J., Yu, G., Haksar, D., de Vries, E., Boons, G-J., de Vries, R. P., de Haan, C. A. M., & Pieters, R. J. (2019). Enhanced Inhibition of Influenza A Virus Adhesion by Di- and Trivalent Hemagglutinin Inhibitors. Journal of Medicinal Chemistry, 62(13), 6398-6404. https://doi.org/10.1021/acs.jmedchem.9b00303
Haksar, D., Asadpoor, M., Heise, T., Shi, J., Braber, S., Folkerts, G., Ballell, L., Rodrigues, J., & Pieters, R. J. (2021). Fighting Shigella by Blocking Its Disease-Causing Toxin. Journal of Medicinal Chemistry, 64(9), 6059-6069. https://doi.org/10.1021/acs.jmedchem.1c00152
Duca, M., Haksar, D., van Neer, J., Thies-Weesie, D. M. E., Martínez-Alarcón, D., de Cock, H., Varrot, A., & Pieters, R. J. (2022). Multivalent Fucosides Targeting β-Propeller Lectins from Lung Pathogens with Promising Anti-Adhesive Properties. ACS Chemical Biology, 17(12), 3515–3526. https://doi.org/10.1021/acschembio.2c00708
Wei, X., Du, W., Duca, M., Yu, G., de Vries, E., de Haan, C. A. M., & Pieters, R. J. (2022). Preventing Influenza A Virus Infection by Mixed Inhibition of Neuraminidase and Hemagglutinin by Divalent Inhibitors. Journal of Medicinal Chemistry, 65(10), 7312-7323. https://doi.org/10.1021/acs.jmedchem.2c00319
Conti, G., Bärenwaldt, A., Rabbani, S., Mühlethaler, T., Sarcevic, M., Jiang, X., Schwardt, O., Ricklin, D., Pieters, R. J., Läubli, H., & Ernst, B. (2023). Tetra- and Hexavalent Siglec-8 Ligands Modulate Immune Cell Activation. Angewandte Chemie-International Edition, e202314280. Advance online publication. https://doi.org/10.1002/anie.202314280
Publications
2024
Scholarly publications
Xu, Y., Wang, X., Zaal, E. A., Berkers, C. R., Lorent, J. H., Heise, T., Cox, R., Pieters, R. J., & Breukink, E. (2024). Specific labeling of newly synthesized lipopolysaccharide via metabolic incorporation of azido-galactose. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 159467. Advance online publication. https://doi.org/10.1016/j.bbalip.2024.159467
2023
Scholarly publications
Zaree, P., Tomris, I., de Vos, S. D., van der Woude, R., Flesch, F. M., Klein Gebbink, R. J. M., de Vries, R. P., & Pieters, R. J. (2023). Facile electrochemical affinity measurements of small and large molecules. RSC Advances, 13(14), 9756-9760. https://doi.org/10.1039/d3ra01029e
https://dspace.library.uu.nl/bitstream/handle/1874/435384/d3ra01029e.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/435384/d3ra01029e.pdf?sequence=1
Conti, G., Bärenwaldt, A., Rabbani, S., Mühlethaler, T., Sarcevic, M., Jiang, X., Schwardt, O., Ricklin, D., Pieters, R. J., Läubli, H., & Ernst, B. (2023). Tetra- and Hexavalent Siglec-8 Ligands Modulate Immune Cell Activation. Angewandte Chemie-International Edition, 62(52), Article e202314280. https://doi.org/10.1002/anie.202314280
Mavrogeni, M. E., Asadpoor, M., Judernatz, J. H., van Ark, I., Wösten, M. M. S. M., Strijbis, K., Pieters, R. J., Folkerts, G., & Braber, S. (2023). Protective Effects of Alginate and Chitosan Oligosaccharides against
Clostridioides difficile Bacteria and Toxin. Toxins, 15(10), 1-23. Article 586. https://doi.org/10.3390/toxins15100586
Balsollier, C., Tomašič, T., Yasini, D., Bijkerk, S., Anderluh, M., & Pieters, R. J. (2023). Design of OSMI-4 Analogs Using Scaffold Hopping: Investigating the Importance of the Uridine Mimic in the Binding of OGT Inhibitors. ChemMedChem, 18(8), Article e202300001. https://doi.org/10.1002/cmdc.202300001
van der Put, R. M. F., Metz, B., & Pieters, R. J. (2023). Carriers and Antigens: New Developments in Glycoconjugate Vaccines. Vaccines, 11(2), 1-25. Article 219. https://doi.org/10.3390/vaccines11020219
https://dspace.library.uu.nl/bitstream/handle/1874/434161/vaccines-11-00219.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/434161/vaccines-11-00219.pdf?sequence=1
Tomris, I., Unione, L., Nguyen, L., Zaree, P., Bouwman, K. M., Liu, L., Li, Z., Fok, J. A., Ríos Carrasco, M., van der Woude, R., Kimpel, A. L. M., Linthorst, M. W., Kilavuzoglu, S. E., Verpalen, E. C. J. M., Caniels, T. G., Sanders, R. W., Heesters, B. A., Pieters, R. J., Jiménez-Barbero, J., ... de Vries, R. P. (2023). SARS-CoV-2 Spike N-Terminal Domain Engages 9-O-Acetylated α2-8-Linked Sialic Acids. ACS Chemical Biology, 18(5), 1180-1191. https://doi.org/10.1021/acschembio.3c00066
https://dspace.library.uu.nl/bitstream/handle/1874/434130/tomris-et-al-2023-sars-cov-2-spike-n-terminal-domain-engages-9-o-acetylated-_2-8-linked-sialic-acids.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/434130/tomris-et-al-2023-sars-cov-2-spike-n-terminal-domain-engages-9-o-acetylated-_2-8-linked-sialic-acids.pdf?sequence=1
2022
Scholarly publications
Mukherjee, R., Somovilla, V. J., Chiodo, F., Bruijns, S., Pieters, R. J., Garssen, J., van Kooyk, Y., Kraneveld, A. D., & van Bergenhenegouwen, J. (2022). Human Milk Oligosaccharide 2′-Fucosyllactose Inhibits Ligand Binding to C-Type Lectin DC-SIGN but Not to Langerin. International Journal of Molecular Sciences, 23(23), Article 14745. https://doi.org/10.3390/ijms232314745
https://dspace.library.uu.nl/bitstream/handle/1874/426693/ijms_23_14745_v2.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/426693/ijms_23_14745_v2.pdf?sequence=1
Liu, Z., Li, X., Lu, Z., Qin, X., Hong, H., Zhou, Z., Pieters, R. J., Shi, J., & Wu, Z. (2022). Repurposing the Pentameric B-Subunit of Shiga Toxin for Gb3-Targeted Immunotherapy of Colorectal Cancer by Rhamnose Conjugation. Journal of Pharmaceutical Sciences, 111(10), 2719-2729. https://doi.org/10.1016/j.xphs.2022.07.017
https://dspace.library.uu.nl/bitstream/handle/1874/426399/1_s2.0_S0022354922003094_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/426399/1_s2.0_S0022354922003094_main.pdf?sequence=1
Hribernik, N., Chiodo, F., Pieters, R. J., & Bernardi, A. (2022). Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies. Tetrahedron Letters, 99, Article 153843. https://doi.org/10.1016/j.tetlet.2022.153843
Tomris, I., Unione, L., Nguyen, L., Zaree, P., Bouwman, K. M., Liu, L., Li, Z., Fok, J. A., Ríos Carrasco, M., van der Woude, R., Kimpel, A. L. M., Linthorst, M. W., Verpalen, E. C. J. M., Caniels, T. G., Sanders, R. W., Heesters, B. A., Pieters, R. J., Jiménez-Barbero, J., Klassen, J. S., ... de Vries, R. P. (2022). The SARS-CoV-2 spike N-terminal domain engages 9-O -acetylated α2-8-linked sialic acids. (pp. 1-25). bioRxiv. https://doi.org/10.1101/2022.09.14.507904
Duca, M., Haksar, D., van Neer, J., Thies-Weesie, D. M. E., Martínez-Alarcón, D., de Cock, H., Varrot, A., & Pieters, R. J. (2022). Multivalent Fucosides Targeting β-Propeller Lectins from Lung Pathogens with Promising Anti-Adhesive Properties. ACS Chemical Biology, 17(12), 3515–3526. https://doi.org/10.1021/acschembio.2c00708
Van Der Put, R. M. F., Spies, A., Metz, B., Some, D., Scherrers, R., Pieters, R., & Danial, M. (2022). Validation of an FFF-MALS Method to Characterize the Production and Functionalization of Outer-Membrane Vesicles for Conjugate Vaccines. Analytical Chemistry, 94(35), 12033-12041. https://doi.org/10.1021/acs.analchem.2c01590
Xu, Y., Hernández-Rocamora, V. M., Lorent, J. H., Cox, R., Wang, X., Bao, X., Stel, M., Vos, G., van den Bos, R. M., Pieters, R. J., Gray, J., Vollmer, W., & Breukink, E. (2022). Metabolic labeling of the bacterial peptidoglycan by functionalized glucosamine. iScience, 25(8), Article 104753. https://doi.org/10.1016/j.isci.2022.104753
Wei, X., Du, W., Duca, M., Yu, G., de Vries, E., de Haan, C. A. M., & Pieters, R. J. (2022). Preventing Influenza A Virus Infection by Mixed Inhibition of Neuraminidase and Hemagglutinin by Divalent Inhibitors. Journal of Medicinal Chemistry, 65(10), 7312-7323. https://doi.org/10.1021/acs.jmedchem.2c00319
Loi, E. M., Tomašič, T., Balsollier, C., van Eekelen, K., Weiss, M., Gobec, M., Alteen, M. G., Vocadlo, D. J., Pieters, R. J., & Anderluh, M. (2022). Discovery of a New Drug-like Series of OGT Inhibitors by Virtual Screening. Molecules (Basel, Switzerland), 27(6), 1-21. Article 1996. https://doi.org/10.3390/molecules27061996
Lu, Z., Liu, Z., Li, X., Qin, X., Hong, H., Zhou, Z., Pieters, R. J., Shi, J., & Wu, Z. (2022). Nanobody-Based Bispecific Neutralizer for Shiga Toxin-Producing E. coli. ACS Infectious Diseases , 8(2), 321-329. https://doi.org/10.1021/acsinfecdis.1c00456
https://dspace.library.uu.nl/bitstream/handle/1874/422227/acsinfecdis.1c00456.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/422227/acsinfecdis.1c00456.pdf?sequence=1
Ayechu-Muruzabal, V., van de Kaa, M., Mukherjee, R., Garssen, J., Stahl, B., Pieters, R. J., Van’T Land, B., Kraneveld, A. D., & Willemsen, L. E. M. (2022). Modulation of the Epithelial-Immune Cell Crosstalk and Related Galectin Secretion by DP3-5 Galacto-Oligosaccharides and β-3′galactosyllactose. Biomolecules, 12(3), 1-15. Article 384. https://doi.org/10.3390/biom12030384
2021
Scholarly publications
Wei, X., & Pieters, R. (2021). Multivalency effects in neuraminidase inhibitor design for influenza virus: This article is dedicated to Professor Horst Kunz on the occasion of his 80th birthday. Arkivoc, 2021(part iv), 297 - 312. https://doi.org/10.24820/ark.5550190.p011.368
Pieters, R. (2021). Design and Development of Divalent Lectin Ligands. In J. J. Barchi, Jr. (Ed.), Comprehensive Glycoscience (2 ed., Vol. 3, pp. 405-413). Elsevier. https://doi.org/10.1016/B978-0-12-819475-1.00088-2
Sewgobind, N. V., Albers, S., & Pieters, R. J. (2021). Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology. Biomolecules, 11(11), 1-25. Article 1720. https://doi.org/10.3390/biom11111720
Martínez-Alarcón, D., Balloy, V., Bouchara, J.-P., Pieters, R. J., & Varrot, A. (2021). Biochemical and structural studies of target lectin SapL1 from the emerging opportunistic microfungus Scedosporium apiospermum. Scientific Reports, 11(1), 1-14. Article 16109. https://doi.org/10.1038/s41598-021-95008-4
Su, X., Ramírez-Escudero, M., Sun, F., van den Dikkenberg, J. B., van Steenbergen, M. J., Pieters, R. J., Janssen, B. J. C., van Hasselt, P. M., Hennink, W. E., & van Nostrum, C. F. (2021). Internalization and transport of PEGylated lipid-based mixed micelles across Caco-2 cells mediated by scavenger receptor B1. Pharmaceutics, 13(12), 1-22. Article 2022. https://doi.org/10.3390/pharmaceutics13122022
Asadpoor, M., Ithakisiou, G.-N., van Putten, J. P. M., Pieters, R. J., Folkerts, G., & Braber, S. (2021). Antimicrobial Activities of Alginate and Chitosan Oligosaccharides Against Staphylococcus aureus and Group B Streptococcus. Frontiers in Microbiology, 12, 1-15. Article 700605. https://doi.org/10.3389/fmicb.2021.700605
Asadpoor, M., Varasteh, S., Pieters, R., Folkerts, G., & Braber, S. (2021). Differential effects of oligosaccharides on the effectiveness of ampicillin against Escherichia coli in vitro. PharmaNutrition, 16(6), 1-9. Article 100264. https://doi.org/10.1016/j.phanu.2021.100264
Zaree, P., Torano, J. S., de Haan, C. A. M., Scheltma, R. A., Barendregt, A., Thijssen, V., Yu, G., Flesch, F., & Pieters, R. J. (2021). The assessment of Pseudomonas aeruginosa lectin LecA binding characteristics of divalent galactosides using multiple techniques. Glycobiology, 31(11), 1490-1499. https://doi.org/10.1093/glycob/cwab074
Bosman, G., Oliviera, S., Simons, P., Sastre Torano, J., Somsen, G. W., Knippels, L., Haselberg, R., Pieters, R., Garssen, J., & Knipping, K. (2021). Limited Lactosylation of Beta-Lactoglobulin from Cow’s Milk Exerts Strong Influence on Antigenicity and Degranulation of Mast Cells. Nutrients, 13(6), 1-13. Article 2041. https://doi.org/10.3390/nu13062041
Haksar, D., Asadpoor, M., Heise, T., Shi, J., Braber, S., Folkerts, G., Ballell, L., Rodrigues, J., & Pieters, R. J. (2021). Fighting Shigella by Blocking Its Disease-Causing Toxin. Journal of Medicinal Chemistry, 64(9), 6059-6069. https://doi.org/10.1021/acs.jmedchem.1c00152
Weiss, M., Loi, E. M., Sterle, M., Balsollier, C., Tomašič, T., Pieters, R. J., Gobec, M., & Anderluh, M. (2021). New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth. Frontiers in Chemistry, 9, 1-8. Article 666122. https://doi.org/10.3389/fchem.2021.666122
Balsollier, C., Pieters, R. J., & Anderluh, M. (2021). Overview of the Assays to Probe O-Linked β-N-Acetylglucosamine Transferase Binding and Activity. Molecules (Basel, Switzerland), 26(4), Article 1037. https://doi.org/10.3390/molecules26041037
Asadpoor, M., Ithakisiou, G.-N., Henricks, P. A. J., Pieters, R., Folkerts, G., & Braber, S. (2021). Non-Digestible Oligosaccharides and Short Chain Fatty Acids as Therapeutic Targets against Enterotoxin-Producing Bacteria and Their Toxins. Toxins, 13(3), Article 175. https://doi.org/10.3390/TOXINS13030175
Shi, J., Sharif, S., Balsollier, C., Ruijtenbeek, R., Pieters, R. J., & Jongkees, S. A. K. (2021). C-Terminal Tag Location Hampers in Vitro Profiling of OGT Peptide Substrates by mRNA Display. ChemBioChem, 22(4), 666-671. https://doi.org/10.1002/cbic.202000624
2020
Scholarly publications
Van Heteren, J., & Pieters, R. J. (2020). Carbohydrate-protein interactions: Enhancing multivalency effects through statistical rebinding. In Carbohydrates in Drug Discovery and Development: Synthesis and Application (pp. 383-402). Elsevier. https://doi.org/10.1016/B978-0-12-816675-8.00009-9
Loi, E. M., Weiss, M., Pajk, S., Gobec, M., Tomašič, T., Pieters, R. J., & Anderluh, M. (2020). Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not Required for Its Inhibition. Molecules (Basel, Switzerland), 25(15), Article 3381. https://doi.org/10.3390/molecules25153381
Asadpoor, M., Peeters, C., Henricks, P. A. J., Varasteh, S., Pieters, R. J., Folkerts, G., & Braber, S. (2020). Anti-pathogenic functions of non-digestible oligosaccharides in vitro. Nutrients, 12(6), Article 1789. https://doi.org/10.3390/nu12061789
Steigenberger, B., van den Toorn, H., Bijl, E., Greisch, J.-F., Räther, O., Lubeck, M., Pieters, R. J., Heck, A. J. R., & Scheltema, R. A. (2020). Benefits of Collisional Cross Section Assisted Precursor Selection (caps-PASEF) for Cross-linking Mass Spectrometry. Molecular and Cellular Proteomics, 19(10), 1677-1687. https://doi.org/10.1074/mcp.RA120.002094
Haksar, D., Quarles Van Ufford, L., & Pieters, R. J. (2020). A hybrid polymer to target blood group dependence of cholera toxin. Organic and Biomolecular Chemistry, 18(1), 52-55. https://doi.org/10.1039/c9ob02369k
2019
Scholarly publications
Mahon, C. S., Wildsmith, G. C., Haksar, D., de Poel, E., Beekman, J. M., Pieters, R. J., Webb, M. E., & Turnbull, W. B. (2019). A 'catch-and-release' receptor for the cholera toxin. Faraday discussions, 219, 112-127. https://doi.org/10.1039/c9fd00017h
https://dspace.library.uu.nl/bitstream/handle/1874/386567/c9fd00017h.pdf?sequence=3
https://dspace.library.uu.nl/bitstream/handle/1874/386567/c9fd00017h.pdf?sequence=3
Steigenberger, B., Pieters, R. J., Heck, A. J. R., & Scheltema, R. A. (2019). PhoX: An IMAC-Enrichable Cross-Linking Reagent. ACS Central Science, 5(9), 1514-1522. https://doi.org/10.1021/acscentsci.9b00416
Zhang, H., Ippel, H., Miller, M. C., Wong, T. J., Griffioen, A. W., Mayo, K. H., & Pieters, R. J. (2019). Hybrid ligands with calixarene and thiodigalactoside groups: Galectin binding and cytotoxicity. Organic Chemistry Frontiers, 6(16), 2981-2990. https://doi.org/10.1039/c9qo00810a
https://dspace.library.uu.nl/bitstream/handle/1874/384837/Hybrid_ligands.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/384837/Hybrid_ligands.pdf?sequence=1
Steigenberger, B., Schiller, H. B., Pieters, R. J., & Scheltema, R. A. (2019). Finding and using diagnostic ions in collision induced crosslinked peptide fragmentation spectra. International Journal of Mass Spectrometry, 444, 1-10. Article 116184. https://doi.org/10.1016/j.ijms.2019.116184
https://dspace.library.uu.nl/bitstream/handle/1874/384784/manuscript.docx?sequence=3
https://dspace.library.uu.nl/bitstream/handle/1874/384784/manuscript.docx?sequence=3
Lu, W., Du, W., Somovilla, V. J., Yu, G., Haksar, D., de Vries, E., Boons, G.-J., de Vries, R. P., de Haan, C. A. M., & Pieters, R. J. (2019). Enhanced Inhibition of Influenza A Virus Adhesion by Di- and Trivalent Hemagglutinin Inhibitors. Journal of Medicinal Chemistry, 62(13), 6398-6404. https://doi.org/10.1021/acs.jmedchem.9b00303
Yu, G., Vicini, A. C., & Pieters, R. J. (2019). Assembly of Divalent Ligands and Their Effect on Divalent Binding to Pseudomonas aeruginosa Lectin LecA. Journal of Organic Chemistry, 84(5), 2470-2488. https://doi.org/10.1021/acs.joc.8b02727
Yu, G., Thies-Weesie, D. M. E., & Pieters, R. J. (2019). Tetravalent Pseudomonas aeruginosa Adhesion Lectin LecA Inhibitor for Enhanced Biofilm Inhibition. Helvetica Chimica Acta, 102(3), Article e190001. https://doi.org/10.1002/hlca.201900014
Lu, W., & Pieters, R. J. (2019). Carbohydrate-protein interactions and multivalency: implications for the inhibition of influenza A virus infections. Expert Opinion on Drug Discovery, 14(4), 387-395. https://doi.org/10.1080/17460441.2019.1573813
Sharif, S., Shi, J., Ruijtenbeek, R., & Pieters, R. J. (2019). Study of cross talk between phosphatases and OGA on a ZO-3-derived peptide. Amino Acids, 51, 739–743. https://doi.org/10.1007/s00726-019-02699-1
Haksar, D., de Poel, E., Quarles van Ufford, L. H. C., Bhatia, S., Haag, R., Beekman, J. M., & Pieters, R. J. (2019). Strong inhibition of cholera toxin B subunit by affordable, polymer-based multivalent inhibitors. Bioconjugate Chemistry, 30(3), 785-792. https://doi.org/10.1021/acs.bioconjchem.8b00902
Mukherjee, R., van de Kaa, M., Garssen, J., Pieters, R. J., Kraneveld, A. D., & Willemsen, L. E. M. (2019). Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk. Food & function, 10(1), 33-37. https://doi.org/10.1039/c8fo02376j
Nemanichvili, N., Tomris, I., Turner, H. L., McBride, R., Grant, O. C., van der Woude, R., Aldosari, M. H., Pieters, R. J., Woods, R. J., Paulson, J. C., Boons, G.-J., Ward, A. B., Verheije, M. H., & de Vries, R. P. (2019). Fluorescent Trimeric Hemagglutinins Reveal Multivalent Receptor Binding Properties. Journal of Molecular Biology, 431(4), 842-856. https://doi.org/10.1016/j.jmb.2018.12.014
2018
Scholarly publications
Stel, M. H., & Pieters, R. J. (2018). Blocking Disease Linked Lectins with Multivalent Carbohydrates. In J. Huskens, L. J. Prins, R. Haag, & B. J. Ravoo (Eds.), Multivalency: Concepts, Research & Applications (1 ed., pp. 345-380). Wiley. https://doi.org/10.1002/9781119143505.ch14
Zhang, H., Tomašič, T., Shi, J., Weiss, M., Ruijtenbeek, R., Anderluh, M., & Pieters, R. J. (2018). Inhibition of: O -GlcNAc transferase (OGT) by peptidic hybrids. MedChemComm, 9(5), 883-887. https://doi.org/10.1039/c8md00115d
Shi, J., Ruijtenbeek, R., & Pieters, R. J. (2018). Demystifying O-GlcNAcylation: hints from peptide substrates. Glycobiology, 28(11), 814-824. https://doi.org/10.1093/glycob/cwy031
van Heugten, A. J. P., de Vries, W. S., Markesteijn, M. M. A., Pieters, R. J., & Vromans, H. (2018). The Role of Excipients in the Stability of Triamcinolone Acetonide in Ointments. AAPS PharmSciTech, 19(3), 1448-1453. https://doi.org/10.1208/s12249-018-0957-8
Mena-Barragán, T., García-Moreno, M. I., Sevšek, A., Okazaki, T., Nanba, E., Higaki, K., Martin, N. I., Pieters, R. J., García Fernández, J. M., & Mellet, C. O. (2018). Probing the inhibitor versus chaperone properties of sp2-iminosugars towards human β-glucocerebrosidase: A picomolar chaperone for gaucher disease. Molecules, 23(4), Article 927. https://doi.org/10.3390/molecules23040927
Zhang, H., Laaf, D., Elling, L., & Pieters, R. J. (2018). Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors. Bioconjugate Chemistry, 29(4), 1266-1275. https://doi.org/10.1021/acs.bioconjchem.8b00047
van Heugten, A. J. P., de Boer, W., de Vries, S. P. W., Pieters, R. J., & Vromans, H. (2018). Topically used corticosteroids: What is the big picture of drug product degradation? European Journal of Pharmaceutical Sciences, 117, 1-7. https://doi.org/10.1016/j.ejps.2018.02.001
https://dspace.library.uu.nl/bitstream/handle/1874/365195/1_s2.0_S0928098718300630_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/365195/1_s2.0_S0928098718300630_main.pdf?sequence=1
Haataja, S., Verma, P., Fu, O., Papageorgiou, A. C., Pöysti, S., Pieters, R. J., Nilsson, U. J., & Finne, J. (2018). Rationally Designed Chemically Modified Glycodendrimer Inhibits Streptococcus suis Adhesin SadP at Picomolar Concentrations. Chemistry - A European Journal, 24(8), 1905-1912. https://doi.org/10.1002/chem.201704493
Brittoli, A., Fallarini, S., Zhang, H., Pieters, R. J., & Lombardi, G. (2018). “In vitro” studies on galectin-3 in human natural killer cells. Immunology Letters, 194, 4-12. https://doi.org/10.1016/j.imlet.2017.12.004
Aizpurua-Olaizola, O., Sastre Torano, J., Pukin, A., Fu, O., Boons, G. J., de Jong, G. J., & Pieters, R. J. (2018). Affinity capillary electrophoresis for the assessment of binding affinity of carbohydrate-based cholera toxin inhibitors. Electrophoresis, 39(2), 344–347. https://doi.org/10.1002/elps.201700207
https://dspace.library.uu.nl/bitstream/handle/1874/362143/Aizpurua_Olaizola_et_al_2018_ELECTROPHORESIS.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/362143/Aizpurua_Olaizola_et_al_2018_ELECTROPHORESIS.pdf?sequence=1
2017
Scholarly publications
Kaa, M. V., Mukherjee, R., Garssen, J., Pieters, R., Willemsen, L., & Kraneveld, A. (2017). Tri-pentamers in galacto-oligosaccharide mixture induce galectin-9 release in CpG dnaprimed activated human intestinal epithelial cells. Allergy: European Journal of Allergy and Clinical Immunology, 72, 5-6. https://doi.org/10.1111/all.13250
Sevsek, A., Sastre Toraño, J., Quarles Van Ufford, L., Moret, E. E., Pieters, R. J., & Martin, N. I. (2017). Orthoester functionalized: N -guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase. MedChemComm, 8(11), 2050-2054. https://doi.org/10.1039/c7md00480j
Sharif, S., Shi, J., Bourakba, M., Ruijtenbeek, R., & Pieters, R. J. (2017). Measuring O-GlcNAc cleavage by OGA and cell lysates on a peptide microarray. Analytical Biochemistry, 532, 12-18. https://doi.org/10.1016/j.ab.2017.05.027
Shi, J., Tomašič, T., Sharif, S., Brouwer, A. J., Anderluh, M., Ruijtenbeek, R., & Pieters, R. J. (2017). Peptide Microarray Analysis of the Cross-talk Between O-GlcNAcylation and Tyrosine Phosphorylation. FEBS Letters, 591(13), 1872-1883. https://doi.org/10.1002/1873-3468.12708
Sevsek, A., Šrot, L., Rihter, J., Čelan, M., van Ufford, L. Q., Moret, E. E., Martin, N. I., & Pieters, R. J. (2017). N-Guanidino Derivatives of 1,5-Dideoxy-1,5-imino-d-xylitol are Potent, Selective, and Stable Inhibitors of β-Glucocerebrosidase. ChemMedChem, 12(7), 483–486. https://doi.org/10.1002/cmdc.201700050
2016
Scholarly publications
Sevšek, A., Čelan, M., Erjavec, B., Quarles van Ufford, L., Sastre Toraño, J., Moret, E. E., Pieters, R. J., & Martin, N. I. (2016). Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase. Organic & Biomolecular Chemistry, 14(37), 8670-3. https://doi.org/10.1039/c6ob01735e
Delaine, T., Collins, P., Mackinnon, A., Sharma, G., Stegmayr, J., Rajput, V. K., Mandal, S., Cumpstey, I., Larumbe, A., Salameh, B. A., Kahl-Knutsson, B., van Hattum, H., van Scherpenzeel, M., Pieters, R. J., Sethi, T., Schambye, H., Oredsson, S., Leffler, H., Blanchard, H., & Nilsson, U. J. (2016). Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition. ChemBioChem, 17(18), 1759-1770. https://doi.org/10.1002/cbic.201600285
Broekgaarden, M., Van Vught, R., Oliveira, S., Roovers, R. C., Van Bergen En Henegouwen, P. M. P., Pieters, R. J., Van Gulik, T. M., Breukink, E., & Heger, M. (2016). Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy. Nanoscale, 8(12), 6490-6494. https://doi.org/10.1039/c6nr00014b
https://dspace.library.uu.nl/bitstream/handle/1874/339445/c6nr00014b.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/339445/c6nr00014b.pdf?sequence=1
Zomer-Van Ommen, D. D., Pukin, A. V., Fu, O., Quarles Van Ufford, L. H. C., Janssens, H. M., Beekman, J. M., & Pieters, R. J. (2016). Functional characterization of cholera toxin inhibitors using human intestinal organoids. Journal of Medicinal Chemistry, 59(14), 6968-6972. https://doi.org/10.1021/acs.jmedchem.6b00770
Shi, J., Sharif, S., Ruijtenbeek, R., & Pieters, R. J. (2016). Activity Based High-Throughput Screening for Novel O-GlcNAc Transferase Substrates Using a Dynamic Peptide Microarray. PLoS One, 11(3), Article e0151085. https://doi.org/10.1371/journal.pone.0151085
2015
Scholarly publications
Visini, R., Jin, X., Bergmann, M., Michaud, G., Pertici, F., Fu, O., Pukin, A., Branson, T. R., Thies-Weesie, D. M. E., Kemmink, J., Gillon, E., Imberty, A., Stocker, A., Darbre, T., Pieters, R. J., & Reymond, J. L. (2015). Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeruginosa Lectin LecA. ACS Chemical Biology, 10(11), 2455-2462. https://doi.org/10.1021/acschembio.5b00302
Pukin, A. V., Brouwer, A. J., Koomen, L., Quarles van Ufford, H. C., Kemmink, J., de Mol, N. J., & Pieters, R. J. (2015). Thiourea-based spacers in potent divalent inhibitors of Pseudomonas aeruginosa virulence lectin LecA. Organic & Biomolecular Chemistry, 13(44), 10923-10928. https://doi.org/10.1039/c5ob01452b
Fu, O., Pukin, A. V., Quarlesvanufford, H. C., Kemmink, J., DeMol, N. J., & Pieters, R. J. (2015). Functionalization of a Rigid Divalent Ligand for LecA, a Bacterial Adhesion Lectin. ChemistryOpen, 4(4), 463-470. https://doi.org/10.1002/open.201402171
Fu, O., Pukin, A. V., Quarles Van Ufford, L., Branson, T. R., Thies-Weesie, D. M. E., Turnbull, W. B., Visser, G. M., & Pieters, R. J. (2015). Tetra- versus Pentavalent Inhibitors of Cholera Toxin. ChemistryOpen, 4(4), 471-477. https://doi.org/10.1002/open.201500006
2014
Scholarly publications
Pera, N. P., & Pieters, R. J. (2014). Towards bacterial adhesion-based therapeutics and detection methods. MedChemComm, 5(8), 1027-1035. https://doi.org/10.1039/c3md00346a
Van Der Wal, S., Fu, O., Rontogianni, S., Pieters, R. J., & Liskamp, R. M. J. (2014). Convenient stereoselective synthesis of substituted ureido glycosides using stable 4-chlorophenylcarbamates without the requirement of Lewis acids. Synlett, 25(2), 205-208. Article ST-2013-B0885-L. https://doi.org/10.1055/s-0033-1340220
Van Vught, R., Pieters, R. J., & Breukink, E. (2014). Site-specific functionalization of proteins and their applications to therapeutic antibodies. Computational and Structural Biotechnology Journal, 9(14), Article e201402001. https://doi.org/10.5936/csbj.201402001
González-Ortiz, G., Quarles Van Ufford, H. C., Halkes, S. B. A., Cerdà-Cuéllar, M., Beukelman, C. J., Pieters, R. J., Liskamp, R. M. J., Pérez, J. F., & Martín-Orue, S. M. (2014). New properties of wheat bran: anti-biofilm activity and interference with bacteria quorum-sensing systems. Environmental Microbiology, 16(5), 1346-1353. https://doi.org/10.1111/1462-2920.12441
Wang, L., Cummings, R. D., Smith, D. F., Huflejt, M., Campbell, C. T., Gildersleeve, J. C., Gerlach, J. Q., Kilcoyne, M., Joshi, L., Serna, S., Reichardt, N.-C., Parera Pera, N., Pieters, R. J., Eng, W., & Mahal, L. K. (2014). Cross-platform comparison of glycan microarray formats. Glycobiology, 24(6), 507-17. https://doi.org/10.1093/glycob/cwu019
González-Ortiz, G., Bronsoms, S., Quarles Van Ufford, H. C., Halkes, S. B. A., Virkola, R., Liskamp, R. M. J., Beukelman, C. J., Pieters, R. J., Pérez, J. F., & Martín-Orúe, S. M. (2014). A proteinaceous fraction of wheat bran may interfere in the attachment of enterotoxigenic E. coli K88 (F4+) to porcine epithelial cells. PLoS One, 9(8), e104258. https://doi.org/10.1371/journal.pone.0104258
2013
Scholarly publications
Pieters, R., Schulz, V., Bol-Schoenmakers, M., & Smit, J. (2013). AhR pathway activation prevents food allergy in mice partly by preserving CD25-positive Tregs in the thymus. Clinical and Translational Allergy, 3(S3). https://doi.org/10.1186/2045-7022-3-s3-p43
Pertici, F., De Mol, N. J., Kemmink, J., & Pieters, R. J. (2013). Optimizing divalent inhibitors of pseudomonas aeruginosa lectin leca by using a rigid spacer. Chemistry - A European Journal, 19(50), 16923-16927. https://doi.org/10.1002/chem.201303463
van Hattum, H., Martin, N. I., Ruijtenbeek, R., & Pieters, R. J. (2013). Development of a microarray detection method for galectin cancer proteins based on ligand binding. Analytical Biochemistry, 99-104. https://doi.org/10.1016/j.ab.2012.11.003
Thomsen, L. B., Linemann, T., Pondman, K. M., Lichota, J., Kim, K. S., Pieters, R. J., Visser, G. M., & Moos, T. (2013). Uptake and Transport of Superparamagnetic Iron Oxide Nanoparticles through Human Brain Capillary Endothelial Cells. ACS Chemical Biology, 19, 16923-16927. https://doi.org/10.1021/cn400093z
Pertici, F., de Mol, N. J., Kemmink, J., & Pieters, R. J. (2013). Optimizing bivalent inhibitors of Pseudomonas aeruginosa lectin LecA using a rigid spacer. Chemistry-A European Journal, 19, 16923-16927.
van Hattum, H., Branderhorst, H. M., Moret, E. E., Nilsson, U. J., Leffler, H., & Pieters, R. J. (2013). Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1. Journal of Medicinal Chemistry, 56(3), 1350-1354. https://doi.org/10.1021/jm301677r
Wittmann, V., & Pieters, R. J. (2013). Bridging lecting binding sites by my multivalent carbohydrates. Chemical Society Reviews, 42(10), 4492-4503. https://doi.org/10.1039/c3cs60089k
Bernardi, A., Jimenez-Barbero, J., Casnati, A., De Castro, C., Darbre, T., Fieschi, F., Finne, J., Funken, H., Jaeger, K.-E., Lahmann, M., Lindhorst, T. K., Marradi, M., Messner, P., Molinaro, A., Murphy, P. V., Nativi, C., Oscarson, S., Penades, S., Peri, F., ... Imberty, A. (2013). Multivalent glycoconjugates as anti-pathogenic agents. Chemical Society Reviews, 42, 4709-4727. https://doi.org/10.1039/c2cs35408j
Kooij, R., Branderhorst, H. M., Bonte, S., Wieclawska, S., Martin, N. I., & Pieters, R. J. (2013). Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives. MedChemComm, 4, 387-393. https://doi.org/10.1039/C2MD20343J
Pieters, R. J., Slotved, H.-C., Moller Mortensen, H., Arler, L., Finne, J., Haataja, S., Joosten, J. A. F., Branderhorst, H. M., & Krogfelt, K. A. (2013). Use of tetravalent galabiose for inhibition of Streptococcus suis serotype 2 infection in a mouse model. Biology, 2, 702-718.
Kouki, A., Pieters, R. J., Nilsson, U. J., Loimaranta, V., Finne, J., & Haataja, S. (2013). Bacterial adhesion of Streptococcus suis to host cells and its inhibition by carbohydrate ligands. Biology, 19, 918-935.
Pertici, F., Varga, N., van Duijn, A., Rey Carrizo, M., Bernardi, A., & Pieters, R. J. (2013). Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors. Beilstein Journal of Organic Chemistry, 9, 215-222.
2012
Scholarly publications
Arnusch, C. J., Pieters, R. J., & Breukink, E. (2012). Enhanced membrane pore formation through high-affinity targeted antimicrobial peptides. PLoS One, 7(6), Article e39768. https://doi.org/10.1371/journal.pone.0039768
Van Esch, B., Van Bilsen, J., Jeurink, P., Garssen, J., Verhoeckx, K., Smit, J., Pieters, R., & Knippels, L. (2012). Multicentre validation of a mouse model for cow's milk allergy to assess the allergenicity of hydrolysed cow's milk based infant formulae. Allergy, 67, 118. https://doi.org/10.1111/all.12034
Pertici, F., & Pieters, R. J. (2012). Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA. Chemical Communications, 48, 4008-4010. https://doi.org/10.1039/c2cc30234a
Chamorro Perez, M. C., Boerman, M. A., Arnusch, C. J., Breukink, E. J., & Pieters, R. J. (2012). Enhancing membrane disruption by targeting and multivalent presentation of antimicrobial peptides. Biochimica et Biophysica Acta-Biomembranes, 1818, 2171-2174.
van Hattum, H., van der Zwaluw, K., Visser, G. M., van Putten, J., Ruijtenbeek, R., & Pieters, R. J. (2012). Functional assay for Shiga-like toxin via detection by antibody capture and multivalent galabiose binding. Bioorganic & Medicinal Chemistry Letters, 22, 7448-7450. https://doi.org/10.1016/j.bmcl.2012.10.053
van der Kaaden, M., Breukink, E. J., & Pieters, R. J. (2012). Synthesis and antifungal properties of papulacandin derivatives. Beilstein Journal of Organic Chemistry, 8, 732-737. https://doi.org/10.3762/bjoc.8.82
Other output
Pieters, R. J., Martin, N. I., Branderhorst, H. M., & Kooij, R. (2012). Urea and guanidinium derivatives of iminosugars. (Patent No. 2009248).
Pieters, R. J., Martin, N. I., Branderhorst, H. M., & Kooij, R. (2012). Urea and guanidinium derivatives of iminosugars. (Patent No. 2009247).
Pieters, R. J., Martin, N. I., Branderhorst, H. M., & Kooij, R. (2012). Urea and guanidinium derivates of iminosugars. (Patent No. 2009246).
2011
Scholarly publications
Pieters, R. J. (2011). Enhanced potencies of multivalent carbohydrates on microarrays and magnetic nanoparticles. Glycoconjugate Journal, 28(5), 259.
Pieters, R. J. (2011). Carbohydrate mediated bacterial adhesion. Advances in Experimental Medicine and Biology, 715, 227-240.
Pieters, R. J. (2011). The role of carbohydrates in bacterial infections. In B. Wang, & G.-J. Boons (Eds.), Carbohydrate Recognition (pp. 93-106). Wiley.
Pieters, R. J. (2011). Enhanced inhibition of protein carbohydrate interactions by dendritic multivalent glycoligands. In X. Huang, & J. J. Barchi (Eds.), Petite and Sweet: Glyco-nanotechnology as a bridge to new medicines (pp. 91-103). American Chemical Society.
Mulder, M. P. C., Kruijtzer, J. A. W., Breukink, E. J., Kemmink, J., Pieters, R. J., & Liskamp, R. M. J. (2011). Synthesis and evaluation of novel macrocyclic antifungal peptides. Bioorganic & Medicinal Chemistry, 19, 6505-6517.
van de Briel, R., Cransveld, C. C., Crommelin, D. J. A., Diamant, Z., Glazenburg, B., Joos, G., Kuper, F., Natsch, A., Nijkamp, F. P., Noteborn, H., Pieters, R. J., Roberts, D., Roggen, E., Rorije, E., van den Heuvel, R., Engelen, J., Verstaelen, S., & van Loveren, H. (2011). Respiratory sensitization: advances in assessing the risk of respiratory inflammation and irritation. Toxicology in Vitro, 25(7), 1251-1258. https://doi.org/10.1016/j.tiv.2011.04.027
Other output
Pieters, R. J. (2011). Het feest van de suikers en andere gasten. Universiteit Utrecht.
https://dspace.library.uu.nl/bitstream/handle/1874/214152/oratietekst_pieters.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/214152/oratietekst_pieters.pdf?sequence=2
2010
Scholarly publications
Parera Pera, N., Branderhorst, H. M., Kooij, R., Maierhofer, C., Van Der Kaaden, M., Liskamp, R. M. J., Wittmann, V., Ruijtenbeek, R., & Pieters, R. J. (2010). Rapid screening of lectins for multivalency effects with a glycodendrimer microarray. ChemBioChem, 11(13), 1896-1904. https://doi.org/10.1002/cbic.201000340
Pieters, R. J. (2010). Towards multivalent carbohydrate drugs. Drug Discovery Today. Technologies, 6, e27-e31.
van Scherpenzeel, M., van den Berg, R. J. B. H. N., Donker-Koopman, W. E., Liskamp, R. M. J., Aerts, J. M. F. G., Overkleeft, H. S., & Pieters, R. J. (2010). Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. Bioorganic & Medicinal Chemistry, 18, 267-273.
Parera Pera, N., Branderhorst, H. M., Kooij, R., Maierhofer, C., van der Kaaden, M., Liskamp, R. M. J., Wittmann, V., Ruijtenbeek, R., & Pieters, R. J. (2010). Rapid screening of lectins of multivalency effects with a glycodendrimer microarray. ChemBioChem, 11, 1896-1904.
Arnusch, C. J., Ippel, J. H., Kooijman, H., Spek, A. L., Liskamp, R. M. J., Kemmink, J., & Pieters, R. J. (2010). Direct structural comparison of a rigid cyclic peptidic scaffold using crystallography and NMR in strained PH polymer gels. European Journal of Organic Chemistry, 4501-4507.
Parera Pera, N., Kouki, A., Haataja, S., Branderhorst, H. M., Liskamp, R. M. J., Visser, G. M., Finne, J., & Pieters, R. J. (2010). Detection of pathogenic streptococcus suis bacteria using magnetic glycoparticles. Organic & Biomolecular Chemistry, 8, 2425-2429.
Other output
Liskamp, R. M. J., Yim, C. B., Merkx, N. S. M., Elgersma, R. C., van Dijk, M., Brouwer, A. J., Boerman, O., van Nostrum, C. F., Hennink, W. E., Pieters, R. J., Kruijtzer, J. A. W., & Rijkers, D. T. S. (2010). Click chemistry in the synthesis of large peptide molecular constructs and peptide-based polymers. 27-28. Abstract from Unknown event.
2009
Scholarly publications
Pieters, R. J. (2009). Toward multivalent carbohydrate drugs. Drug Discovery Today: Technologies, 6(1-4), e27-e31. https://doi.org/10.1016/j.ddtec.2009.12.001
Kuil, J., Branderhorst, H. M., Pieters, R. J., de Mol, N. J., & Liskamp, R. M. J. (2009). ITAM-derived phosphopeptide-containing dendrimers as multivalent ligands for Syk tandem SH2 domain. Organic & Biomolecular Chemistry, 7, 4088-4094.
van Scherpenzeel, M., Moret, E. E., Ballell, L., Liskamp, R. M. J., Nilsson, U. J., Leffler, H., & Pieters, R. J. (2009). Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3. ChemBioChem, 10, 1724-1733.
Pieters, R. J. (2009). Maximising multivalency effects in protein-carbohydrate interactions. Organic & Biomolecular Chemistry, 7, 2013-2025.
Pieters, R. J. (2009). Multivalency effects and the inhibition of carbohydrate-based adhesion of bacteria and bacterial toxins. In Progress in the synthesis of complex carbohydrate chains of plant and microbial polysaccharides (pp. 549-562). Transworld Research Network.
Pieters, R. J., Arnusch, C. J., & Breukink, E. J. (2009). Membrane permeabilization by multivalent anti-microbial peptides. Proteins peptide letters, 16, 736-742.
Sisu, C., Baron, A. J., Branderhorst, H. M., Connel, S. D., Weijers, C. A. G. M., de Vries, R., Hayes, E. D., Pukin, A. V., Gilbert, M., Pieters, R. J., Zuilhof, H., Visser, G. M., & Turnball, W. B. (2009). The influence of ligand valency on aggregation mechanisms for inhibiting bacterial toxins. ChemBioChem, 10, 329-337.
Albada, H. B., Arnusch, C. J., Branderhorst, H. M., Verel, A. M., Janssen, W. T. M., Breukink, E. J., de Kruijff, B., Pieters, R. J., & Liskamp, R. M. J. (2009). Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions. Bioorganic & Medicinal Chemistry Letters, 19, 3721-3724.
2008
Scholarly publications
Branderhorst, H. M., Ruijtenbeek, R., Liskamp, R. M. J., & Pieters, R. J. (2008). Multivalent carbohydrate recognition on a glycodendrimer-functionalized flow-through chip. ChemBioChem, 9, 1836-1844.
Arnusch, C. J., Bonvin, A. M. J. J., Verel, A. M., Jansen, W. T. M., Liskamp, R. M. J., de Kruijff, B., Pieters, R. J., & Breukink, E. J. (2008). The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant enterococci. Biochemistry, 47(48), 12661-12663. https://doi.org/10.1021/bi801597b
Branderhorst, H. M., Kooij, R., Salminen, A., Jongeneel, L. H., Arnusch, C. J., Liskamp, R. M. J., Finne, J., & Pieters, R. J. (2008). Synthesis of multivalent Streptococcus suis adhesion inhibitors by enzymatic cleavage of polygalacturonic acid and 'click' conjugation. Organic & Biomolecular Chemistry, 6(8), 1425-1434. https://doi.org/10.1039/b800283e
Pieters, R. J., & Liskamp, R. M. J. (2008). Multivalent presentation strategies in novel inhibitors of bacterial (toxin) adhesion and synthetic vaccines. Anti-Infective Agents in Medicinal Chemistry, 7, 193-200.
2007
Scholarly publications
Pukin, A. V., Branderhorst, H. M., Sisu, C., Weijers, C. A. G. M., Gilbert, M., Liskamp, R. M. J., Visser, G. M., Zuilhof, H., & Pieters, R. J. (2007). Strong inhibition of cholera toxin by multivalent GM1 derivatives. ChemBioChem, 8(13), 1500-1503. https://doi.org/10.1002/cbic.200700266
Arnusch, C. J., Branderhorst, H., De Kruijff, B., Liskamp, R. M. J., Breukink, E., & Pieters, R. J. (2007). Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides. Biochemistry, 46(46), 13437-13442. https://doi.org/10.1021/bi7015553
Branderhorst, H. M., Liskamp, R. M. J., Visser, G. M., & Pieters, R. J. (2007). Strong inhibition of cholera toxin binding by galactose dendrimers. Chemical Communications, 5043-5045.
Pieters, R. J. (2007). Intervention with bacterial adhesion by multivalent carbohydrates. Medicinal Research Reviews, 27, 796-816.
van Zoelen, D. J., Egmond, M. R., Pieters, R. J., & Liskamp, R. M. J. (2007). Synthesis and evaluation of TAC-based inhibitors of papain as mimics of cystatin B. ChemBioChem, 8, 1950-1956.
https://dspace.library.uu.nl/bitstream/handle/1874/26400/vanZoelen%25202007%2520pp%25201950-56.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/26400/vanZoelen%25202007%2520pp%25201950-56.pdf?sequence=2
Pieters, R. J., Rijkers, D. T. S., & Liskamp, R. M. J. (2007). Application of the 1,3-dipolar cycloaddition reaction in chemical biology: approaches toward multivalent carbohydrates and peptides and peptide-based polymers. QSAR & Combinatorial Science, 26, 1181-1190.
Arnusch, C. J., Branderhorst, H. M., de Kruijff, B., Liskamp, R. M. J., Breukink, E. J., & Pieters, R. J. (2007). Enhanced membrane pore information by multimeric/oligomeric antimicrobial peptides. Biochemistry, 46, 13437-13442.
https://dspace.library.uu.nl/bitstream/handle/1874/26122/Arnusch-Enhanced%2520membrane.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/26122/Arnusch-Enhanced%2520membrane.pdf?sequence=1
Branderhorst, H. M., Liskamp, R. M. J., & Pieters, R. J. (2007). Solid phase carbohydrate synthesis via on-bead protecting group chemistry. Tetrahedron Letters, 63, 4290-4296.
van Scherpenzeel, M., van der Pot, M., Arnusch, C. J., Liskamp, R. M. J., & Pieters, R. J. (2007). Detection of galectin-3 by novel peptidic photoprobes. Bioorganic & Medicinal Chemistry Letters, 17, 376-378.
Salminen, A., Loimaranta, V., Joosten, J. A. F., Khan, A. S., Hacker, J., Pieters, R. J., & Finne, J. (2007). Inhibition of P-fimbriated Escherichia coli adhesion by multivalent galabiose derivatives studied by a live-bacteria application of surface plasmon resonance. Journal of Antimicrobial Chemotherapy, 60, 495-501.
Pukin, A. V., Branderhorst, H. M., Sisu, C., Weijers, C. A. G. M., Gilbert, M., Liskamp, R. M. J., Visser, G. M., Zuilhof, H., & Pieters, R. J. (2007). Strong inhibition of cholera toxin by multivalent GM1 derivatives. ChemBioChem, 8, 1500-1503.
Other output
Pieters, R. J., Pukin, A. V., Aliaksei, V., Branderhorst, H. M., Weijers, C. A. G. M., Gilbert, M., Liskamp, R. M. J., Visser, G. M., & Zuilhof, H. (2007). Strong inhibition of cholera toxin by multivalent GM1 derivatives. Abstract from 234th ACS National Meeting.
Pieters, R. J., Arnusch, C. J., Liskamp, R. M. J., & Breukink, E. J. (2007). Targeted, multivalent antimicrobial peptides. Abstract from 234th ACS National Meeting.
2006
Scholarly publications
Kasyanov, V., Isenburg, J., Draughn, R. A., Hazard, S., Hodde, J., Ozolanta, I., Murovska, M., Halkes, S. B. A., Vrasidas, I., Liskamp, R. M. J., Pieters, R. J., Simionescu, D., Markwald, R. R., & Mironov, V. (2006). Tannic acid mimicking dendrimers as small intestine submucosa stabilizing nanomordants. Biomaterials, 27, 745-751.
Ballell Pages, L., van Scherpenzeel, M., Buchalova, K., Liskamp, R. M. J., & Pieters, R. J. (2006). A new chemical probe for the detection of the cancer-linked galectin-3. Organic & Biomolecular Chemistry, 4, 4387-4394.
Pieters, R. J. (2006). Inhibition and detection of galectins. ChemBioChem, 7, 721-728.
2005
Scholarly publications
André, S., Arnusch, C. J., Kuwabara, I., Russwurm, R., Kaltner, H., Gabius, H.-J., & Pieters, R. J. (2005). Identification of peptide ligands for malignancy- and growth-regulating galectins using random phage-display and designed combinatorial peptide libraries. Bioorganic and Medicinal Chemistry, 13(2), 563-573. https://doi.org/10.1016/j.bmc.2004.09.053
Joosten, J. A. F., Tholen, N. T. H., Ait El Maate, F., Brouwer, A. J., Wilma Van Esse, G., Rijkers, D. T. S., Liskamp, R. M. J., & Pieters, R. J. (2005). High-yielding microwave-assisted synthesis of triazole-linked glycodendrimers by copper-catalyzed [3+2] cycloaddition. European Journal of Organic Chemistry, (15), 3182-3185. https://doi.org/10.1002/ejoc.200500216
André, S., Arnusch, C. J., Kuwabara, I., Russwurm, R., Kaltner, H., Gabius, H.-J., & Pieters, R. J. (2005). Identification of peptide ligands for malignancy and growth-regulation galectins using random phage-display and designed combinatorial peptide libraries. Bioorganic & Medicinal Chemistry, 13, 563-573.
Rijkers, D. T. S., van Esse, G. W., Merkx, N. S. M., Brouwer, A. J., Jacobs, J. J. F., Pieters, R. J., & Liskamp, R. M. J. (2005). Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry. Chemical Communications, 4581-4583.
Ballell Pages, L., Alink, K. J., Slijper, M., Versluis, C., Liskamp, R. M. J., & Pieters, R. J. (2005). A new chemical probe for proteomics of carbohydrate-binding proteins. ChemBioChem, 6, 291-295.
Joosten, J. A. F., Tholen, N. T. H., ait el Maate, F., Brouwer, A. J., van Esse, G. W., Rijkers, D. T. S., Liskamp, R. M. J., & Pieters, R. J. (2005). High-yielding microwave-assisted synthesis of triazole-linked glycodendrimers via copper-catalyzed [3+2] cycloaddition. European Journal of Organic Chemistry, 3182-3185.
Benedek, O., Khan, A. S., Schneider, G., Nagy, G., Autar, R., Pieters, R. J., & Emödy, L. (2005). Identification of laminin-binding motifs of Yersinia pestis plasminogen activator by phage display. International Journal of Medical Microbiology, 295, 87-98.
Autar, R., Liskamp, R. M. J., & Pieters, R. J. (2005). A facile synthesis of the GalNAc beta 1 -> 4Gal target sequence of respiratory pathogens. Carbohydrate Research, 340, 2436-2442.
Appeldoorn, C. C. M., Joosten, J. A. F., ait el Maate, F., Dobrindt, U., Hacker, J., Liskamp, R. M. J., Khan, A. S., & Pieters, R. J. (2005). Novel multivalent mannose compounds and their inhibition of the adhesion of type 1 fimbriated uropathogenic E. coli. Tetrahedron-Asymmetry, 16, 361-372.
Popularising publications
Pieters, R. J. (2005). Synthetic probes for the selective capture of galectins. NPC Highlights, 12-15.
Other output
Liskamp, R. M. J., Rijkers, D. T. S., Pieters, R. J., Brouwer, A. J., & Joosten, J. A. F. (2005). Dendrimers multivalenty substituted with active groups as pharmaceutical or diagnostic agents. (Patent No. 05076421.6).
2004
Scholarly publications
Arosio, D., Vrasidas, I., Valentini, P., Liskamp, R. M. J., Pieters, R. J., & Bernardi, A. (2004). Synthesis and cholera toxin binding properties of multivalent GM1 mimics. Organic & Biomolecular Chemistry, 2(14), 2113-2124. https://doi.org/10.1039/B405344C
Arnusch, C. J., André, S., Valentini, P., Lensch, M., Russwurm, R., Siebert, H.-C., Fischer, M. J. E., Gabius, H.-J., & Pieters, R. J. (2004). Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands. Bioorganic and Medicinal Chemistry Letters, 14(6), 1437-1440. https://doi.org/10.1016/j.bmcl.2004.01.029
Pieters, R. J. (2004). Interference with lectin binding and bacterial adhesion by multivalent carbohydrates and peptidic carbohydrate mimics. Trends in Glycoscience and Glycotechnology, 16, 243-254.
Arnusch, C. J., & Pieters, R. J. (2004). Synthesis of a novel 14-membered highly constrained cyclic peptidic scaffold. Tetrahedron Letters, 45, 4153-4156.
Arnusch, C. J., Andre, S., Valentini, P., Lensch, M., Russworm, R., Siebert, H.-C., Fischer, M. J. E., Gabius, H.-J., & Pieters, R. J. (2004). Interference of the galactose-dependant binding of lectins by novel pentapeptide ligands. Bioorganic & Medicinal Chemistry Letters, 14, 1437-1440.
Ballell Pages, L., Joosten, J. A. F., ait el Maate, F., Liskamp, R. M. J., & Pieters, R. J. (2004). Microwave-assisted, tin-mediated, regioselective 3-O-alkylation of galactosides. Tetrahedron Letters, 45, 6685-6687.
Joosten, J. A. F., Loimaranta, V., Appeldoorn, C. C. M., Haataja, S., ait el Maate, F., Liskamp, R. M. J., Finne, J., & Pieters, R. J. (2004). Inhibition of Streptococcus Suis adhesion by dendritic galabiose compounds at low nanomolar concentration. Journal of Medicinal Chemistry, 47, 6499-6508.
2003
Scholarly publications
Arnusch, C. J., & Pieters, R. J. (2003). Solid phase synthesis of vancomycin mimics. European Journal of Organic Chemistry, (16), 3131-3138. https://doi.org/10.1002/ejoc.200300044
Kopitz, J., André, S., Von Reitzenstein, C., Versluis, C., Kaltner, H., Pieters, R. J., Wasano, K., Kuwabara, I., Liu, F.-T., Cantz, M., Heck, A. J. R., & Gabius, H.-J. (2003). Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells. Oncogene, 22, 6277-6288.
Vrasidas, I., Andre, S., Valentini, P., Bock, C., Lensch, M., Kaltner, H., Liskamp, R. M. J., Gabius, H.-J., & Pieters, R. J. (2003). Rigidified multivalent lactose molecules and their interactions with mammalian galectins: a route to selective inhibitors. Organic & Biomolecular Chemistry, 1, 803-810.
Arnusch, C. J., & Pieters, R. J. (2003). Solid phase synthesis of Vancomycine mimics. European Journal of Organic Chemistry, 3131-3138.
Autar, R., Khan, A. S., Schad, M., Hacker, J., Liskamp, R. M. J., & Pieters, R. J. (2003). Adhesion inhibition of F1C-fimbriated Escherichia coli and Pseudomonas aeruginosa PAK and PAO by multivalent carbohydrate ligands. ChemBioChem, 4, 1317-1325.
2002
Scholarly publications
Vrasidas, I., Kemmink, J., Liskamp, R. M. J., & Pieters, R. J. (2002). Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate. Organic Letters, 4, 1807-1808.
Halkes, S. B. A., Vrasidas, I., Rooijer, G. R., van den Berg, A. J. J., Liskamp, R. M. J., & Pieters, R. J. (2002). Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics. Bioorganic & Medicinal Chemistry Letters, 12, 1567-1570.
Branderhorst, H. M., Kemmink, J., Liskamp, R. M. J., & Pieters, R. J. (2002). Catalytic conversions of diazosugars. Tetrahedron Letters, 43, 9601-9603.
2001
Scholarly publications
Pieters, R. J., Lutje Spelberg, J. H., Kellogg, R. M., & Janssen, D. B. (2001). The enantioselectivity of haloalkane dehalogenases. Tetrahedron Letters, 42, 469-471.
Vrasidas, I., de Mol, N. J., Liskamp, R. M. J., & Pieters, R. J. (2001). Synthesis of lactose dendrimers and multivalency effects in binding to the cholera toxin B subunit. European Journal of Organic Chemistry, 4685-4692.
André, S., Pieters, R. J., Vrasidas, I., Kaltner, H., Kuwabara, I., Liu, F.-T., Liskamp, R. M. J., & Gabius, H.-J. (2001). Wedgelike glycodendrimers as inhibitors of binding of mammalian galectins to glycoproteins, lactose maxiclusters, and cell surface glycoconjugates. ChemBioChem, 2, 822-830.
2000
Scholarly publications
Pieters, R. J. (2000). Synthesis and binding studies of carboxylate binding pocket analogs of Vancomycin. Tetrahedron Letters, 41, 7541.
1999
Scholarly publications
Rink, R., Lutje Spelberg, J. H., Pieters, R. J., Kingma, J., Nardini, M., Kellogg, R. M., Dijkstra, B. W., & Janssen, D. B. (1999). Mutation of tyrosine residues involved in the alkylation half reaction of epoxide hydrolase from Agrobacterium radiobacter AD1 results in improved enantioselectivity [7]. Journal of the American Chemical Society, 121(32), 7417-7418. https://doi.org/10.1021/ja990501o
Pieters, R. J., Fennema, M., Kellogg, R. M., & Janssen, D. B. (1999). Design and synthesis of reagents for phage display screening of dehalogenases. Bioorganic and Medicinal Chemistry Letters, 9(2), 161-166. https://doi.org/10.1016/S0960-894X(98)00697-0
Other output
Vrasidas, I., Pieters, R. J., & Liskamp, R. M. J. (1999). Carbohydrate dendrimers as multivalent anti-adhesion ligands. Abstract from 1st International dendrimer symposium, Frankfurt/Main, Germany.
1997
Scholarly publications
Pieters, R. J., Cuntze, J., Bonnet, M., & Diederich, F. (1997). Enantioselective recognition with C3-symmetric cage-like receptors in solution and on a stationary phase. Journal of the Chemical Society. Perkin Transactions 2, (10), 1891-1900. https://doi.org/10.1039/a702627g
1996
Scholarly publications
Pieters, R. J., & Diederich, F. (1996). Enantioselective complexation of excitatory amino acid derivatives by chiral, cage-like C3-symmetrical receptors. Chemical Communications, (19), 2255-2256. https://doi.org/10.1039/cc9960002255
1995
Scholarly publications
Tsao, B. L., Pieters, R. J., & Rebek, J. (1995). Convergent Functional Groups. 16. Hydrolysis of Phosphate Triesters by a Novel Cleft. Influence of Binding on Overall Rate Acceleration. Journal of the American Chemical Society, 117(8), 2210-2213. https://doi.org/10.1021/ja00113a010
Pieters, R. J., Huc, I., & Rebek, J. (1995). Reciprocal template effects in bisubstrate systems: A replication cycle. Tetrahedron, 51(2), 485-498. https://doi.org/10.1016/0040-4020(94)00910-M
Pieters, R. J., Huc, I., & Rebek, J. (1995). Passive Template Effects and Active Acid‐Base Involvement in Catalysis of Organic Reactions. Chemistry – A European Journal, 1(3), 183-192. https://doi.org/10.1002/chem.19950010307
Doyle, M. P., Bailey, A. S., Dyatkin, A. B., Kalinin, A. V., Kwan, M. M. Y., Pieters, R. J., Protopopova, M. N., Raab, C. E., Roos, G. H. P., Zhou, Q. L., Austin, R. E., Dwyer, M. P., Liras, S., Oalmann, C. J., & Martin, S. F. (1995). Enantioselective Intramolecular Cyclopropanations of Allylic and Homoallylic Diazoacetates and Diazoacetamides Using Chiral Dirhodium (II) Carboxamide Catalysts. Journal of the American Chemical Society, 117(21), 5763-5775. https://doi.org/10.1021/ja00126a016
1994
Scholarly publications
Huc, I., Pieters, R. J., & Rebek, J. (1994). Role of Geometrical Factors in Template Effects. Journal of the American Chemical Society, 116(22), 10296-10297. https://doi.org/10.1021/ja00101a058
Huc, I., Pieters, R. J., & Rebek, J. (1994). Intracomplex Catalysis of Acylation Reactions. Journal of the American Chemical Society, 116(25), 11592-11593. https://doi.org/10.1021/ja00104a059
1993
Scholarly publications
Pieters, R. J., & Rebek, J. (1993). Convergent functional groups XIV. Synthesis and binding studies of new molecular clefts for recognition and catalysis. Recueil des Travaux Chimiques des Pays‐Bas, 112(6), 330-334. https://doi.org/10.1002/recl.19931120604
1991
Scholarly publications
Doyle, M. P., Pieters, R. J., Martin, S. F., Austin, R. E., Oalmann, C. J., & Müller, P. (1991). High Enantioselectivity in the Intramolecular Cyclopropanation of Allyl Diazoacetates Using a Novel Rhodium(II) Catalyst. Journal of the American Chemical Society, 113(4), 1423-1424. https://doi.org/10.1021/ja00004a059
Doyle, M. P., Pieters, R. J., Taunton, J., Pho, H. Q., Padwa, A., Hertzog, D. L., & Precedo, L. (1991). Synthesis of Nitrogen-Containing Polycycles via Rhodium(II)-Induced Cyclization-Cycloaddition and Insertion Reactions of N-(Diazoacetoacetyl)amides. Conformational Control of Reaction Selectivity. Journal of Organic Chemistry, 56(2), 820-829. https://doi.org/10.1021/jo00002a058
1990
Scholarly publications
Doyle, M. P., High, K. G., Bagheri, V., Pieters, R. J., Lewis, P. J., & Pearson, M. M. (1990). Rhodium(II) Perfluorobutyrate Catalyzed Silane Alcoholysis. A Highly Selective Route to Silyl Ethers. Journal of Organic Chemistry, 55(25), 6082-6086. https://doi.org/10.1021/jo00312a010
Doyle, M. P., Brandes, B. D., Kazala, A. P., Pieters, R. J., Jarstfer, M. B., Watkins, L. M., & Eagle, C. T. (1990). Chiral rhodium(II) carboxamides. A new class of catalysts for enantioselective cyclopropanation reactions. Tetrahedron Letters, 31(46), 6613-6616. https://doi.org/10.1016/S0040-4039(00)97128-4