Dr. R.H.S. (Remco) Westerink

Associate Professor
One Health Toxicology
+31 6 48 456 256
r.westerink@uu.nl

Publications

2021

Scholarly publications

Prado, J., Westerink, R. H. S., Popov-Celeketic, J., Steen-Louws, C., Pandit, A., Versteeg, S., van de Worp, W., Kanters, D. H. A. J., Reedquist, K. A., Koenderman, L., Hack, C. E., & Eijkelkamp, N. (2021). Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways. Proceedings of the National Academy of Sciences of the United States of America, 118(11), [e2009647118]. https://doi.org/10.1073/pnas.2009647118
Kasteel, E. E. J., & Westerink, R. H. S. (2021). Refining in vitro and in silico neurotoxicity approaches by accounting for interspecies and interindividual differences in toxicodynamics. Expert Opinion on Drug Metabolism and Toxicology. https://doi.org/10.1080/17425255.2021.1885647
Tukker, A. M., & Westerink, R. H. S. (2021). Novel test strategies for in vitro seizure liability assessment. Expert Opinion on Drug Metabolism and Toxicology. https://doi.org/10.1080/17425255.2021.1876026
He, R-W., Braakhuis, H. M., Vandebriel, R. J., Staal, Y. C. M., Gremmer, E. R., Fokkens, P. H. B., Kemp, C., Vermeulen, J., Westerink, R. H. S., & Cassee, F. R. (2021). Optimization of an air-liquid interface in vitro cell co-culture model to estimate the hazard of aerosol exposures. Journal of Aerosol Science, 153, [105703]. https://doi.org/10.1016/j.jaerosci.2020.105703

2020

Scholarly publications

de Leeuw, V. C., van Oostrom, C. T. M., Westerink, R. H. S., Piersma, A. H., Heusinkveld, H. J., & Hessel, E. V. S. (2020). An efficient neuron-astrocyte differentiation protocol from human embryonic stem cell-derived neural progenitors to assess chemical-induced developmental neurotoxicity. Reproductigve Toxicoloy, 98, 107-116. https://doi.org/10.1016/j.reprotox.2020.09.003
Kasteel, E. E. J., Nijmeijer, S. M., Darney, K., Lautz, L. S., Dorne, J. L. C. M., Kramer, N. I., & Westerink, R. H. S. (2020). Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics. Archives of Toxicology, 94(12), 4055-4065. https://doi.org/10.1007/s00204-020-02927-8
Tukker, A. M., Wijnolts, F. M. J., de Groot, A., & Westerink, R. H. S. (2020). Applicability of hiPSC-Derived Neuronal Cocultures and Rodent Primary Cortical Cultures for In Vitro Seizure Liability Assessment. Toxicological Sciences, 178(1), 71-87. https://doi.org/10.1093/toxsci/kfaa136
de Korte, T., Nacken, P., Zwartsen, A., Westerink, R., & Hondebrink, L. (2020). Cardiotoxicity screening of recreational drugs in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings. Journal of Pharmacological and Toxicological Methods, 105, [106700]. https://doi.org/10.1016/j.vascn.2020.106700
Bauer, L., Manganaro, R., Zonsics, B., Hurdiss, D. L., Zwaagstra, M., Donselaar, T., Welter, N. G. E., van Kleef, R. G. D. M., Lopez, M. L., Bevilacqua, F., Raman, T., Ferla, S., Bassetto, M., Neyts, J., Strating, J. R. P. M., Westerink, R. H. S., Brancale, A., & van Kuppeveld, F. J. M. (2020). Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C. PLoS Biology, 18(11), [e3000904]. https://doi.org/10.1371/journal.pbio.3000904
Zwartsen, A., Hondebrink, L., de Lange, D. W., & Westerink, R. H. S. (2020). Hyperthermia exacerbates the acute effects of psychoactive substances on neuronal activity measured using microelectrode arrays (MEAs) in rat primary cortical cultures in vitro. Toxicology and Applied Pharmacology, 397, [115015]. https://doi.org/10.1016/j.taap.2020.115015
Zwartsen, A., Olijhoek, M., Westerink, R. H. S., & Hondebrink, L. (2020). Hazard Characterization of Synthetic Cathinones Using Viability, Monoamine Reuptake, and Neuronal Activity Assays. Frontiers in Neuroscience, 14, 1-12. [9]. https://doi.org/10.3389/fnins.2020.00009
Tukker, A. M., Bouwman, L. M. S., van Kleef, R. G. D. M., Hendriks, H. S., Legler, J., & Westerink, R. H. S. (2020). Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) acutely affect human α1β2γ2L GABAA receptor and spontaneous neuronal network function in vitro. Scientific Reports, 10(1), [5311]. https://doi.org/10.1038/s41598-020-62152-2
Post, Y., Puschhof, J., Beumer, J., Kerkkamp, H. M., de Bakker, M. A. G., Slagboom, J., de Barbanson, B., Wevers, N. R., Spijkers, X. M., Olivier, T., Kazandjian, T. D., Ainsworth, S., Iglesias, C. L., van de Wetering, W. J., Heinz, M. C., van Ineveld, R. L., van Kleef, R. G. D. M., Begthel, H., Korving, J., ... Clevers, H. (2020). Snake Venom Gland Organoids. Cell, 180(2), 233-247. [e21]. https://doi.org/10.1016/j.cell.2019.11.038
Zwartsen, A., Verboven, A. H. A., van Kleef, R. G. D. M., Wijnolts, F. M. J., Westerink, R. H. S., & Hondebrink, L. (2020). Corrigendum to "Measuring inhibition of monoamine reuptake transporters by new psychoactive substances (NPS) in real-time using a high-throughput, fluorescence-based assay" [Toxicology in Vitro (2017) 60-71]. Toxicology in Vitro, 62, [104631]. https://doi.org/10.1016/j.tiv.2019.104631

2019

Scholarly publications

Tukker, A. M., Wijnolts, F. M. J., de Groot, A., Wubbolts, R. W., & Westerink, R. H. S. (2019). In vitro techniques for assessing neurotoxicity using human IPSC-derived neuronal models. In M. Aschner, & L. Costa (Eds.), Cell Culture Techniques (pp. 17-35). (Neuromethods; Vol. 145). Humana Press. https://doi.org/10.1007/978-1-4939-9228-7_2
Bal-Price, A., Hogberg, H. T., Crofton, K. M., Daneshian, M., FitzGerald, R. E., Fritsche, E., Heinonen, T., Hougaard Bennekou, S., Klima, S., Piersma, A. H., Sachana, M., Shafer, T. J., Terron, A., Monnet-Tschudi, F., Viviani, B., Waldmann, T., Westerink, R. H. S., Wilks, M. F., Witters, H., ... Leist, M. (2019). Corrigendum to Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity. Altex, 36(3), 506. https://doi.org/10.14573/altex.1904112
Zwartsen, A., Litjens, C. H. C., Hondebrink, L., van den Heuvel, J. J. M. W., Greupink, R., Russel, F. G. M., de Lange, D. W., Legler, J., Koenderink, J. B., & Westerink, R. H. S. (2019). Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT). Toxicology, 422, 69-75. https://doi.org/10.1016/j.tox.2019.04.012
Zwartsen, A., Hondebrink, L., & Westerink, R. H. (2019). Changes in neuronal activity in rat primary cortical cultures induced by illicit drugs and new psychoactive substances (NPS) following prolonged exposure and washout to mimic human exposure scenarios. NeuroToxicology, 74, 28-39. https://doi.org/10.1016/j.neuro.2019.05.004
Richardson, J. R., Fitsanakis, V., Westerink, R. H. S., & Kanthasamy, A. G. (2019). Neurotoxicity of pesticides. Acta Neuropathologica, 138(3), 343-362. [138]. https://doi.org/10.1007/s00401-019-02033-9
Zwartsen, A., de Korte, T., Nacken, P., de Lange, D. W., Westerink, R. H. S., & Hondebrink, L. (2019). Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings. Journal of Molecular and Cellular Cardiology, 136, 102-112. https://doi.org/10.1016/j.yjmcc.2019.09.007

2018

Scholarly publications

Dusza, H. M., Cenijn, P. H., Kamstra, J. H., Westerink, R. H. S., Leonards, P. E. G., & Hamers, T. (2018). Effects of environmental pollutants on calcium release and uptake by rat cortical microsomes. NeuroToxicology, 69, 266-277. https://doi.org/10.1016/j.neuro.2018.07.015
Westerink, R. H. S., van Thriel, C., Levin, E. D., & Shafer, T. J. (2018). From molecular mechanisms to functional impact: Developing integrated analyses in neurotoxicology - The 16th biennial meeting International Neurotoxicology Association and 8th meeting of the NeuroToxicity Society. NeuroToxicology, 72, 125-126. https://doi.org/10.1016/j.neuro.2018.11.002
Zwartsen, A., & Westerink, R. H. (2018). Neurotoxicity screening of new psychoactive substances (NPS): Effects on neuronal activity in rat cortical cultures using microelectrode arrays (MEA). NeuroToxicology, 66, 87-97. https://doi.org/10.1016/j.neuro.2018.03.007
Tukker, A. M., Wijnolts, F. M. J., de Groot, A., & Westerink, R. H. S. (2018). Human iPSC-derived neuronal models for in vitro neurotoxicity assessment. NeuroToxicology, 67, 215-225. https://doi.org/10.1016/j.neuro.2018.06.007
Bal-Price, A., Hogberg, H. T., Crofton, K. M., Daneshian, M., FitzGerald, R. E., Fritsche, E., Heinonen, T., Hougaard Bennekou, S., Klima, S., Piersma, A. H., Sachana, M., Shafer, T. J., Terron, A., Monnet-Tschudi, F., Viviani, B., Waldmann, T., Westerink, R. H. S., Wilks, M. F., Witters, H., ... Leist, M. (2018). Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity. Altex, 35(3), 306-352. https://doi.org/10.14573/altex.1712081
Hondebrink, L., Zwartsen, A., & Westerink, R. H. S. (2018). Effect fingerprinting of new psychoactive substances (NPS): What can we learn from in vitro data? Pharmacology & Therapeutics, 182, 193-224. https://doi.org/10.1016/j.pharmthera.2017.10.022

Other output

Heusinkveld, H. J., & Westerink, R. H. S. (2018). The organophosphate insecticides diazinon and chlorpyrifos disturb neuronal network function in a rat primary cortical cultures. Poster session presented at SOT , San Antonio, United States.

2017

Scholarly publications

Zwartsen, A., Verboven, A. H. A., van Kleef, R. G. D. M., Wijnolts, F. M. J., Westerink, R. H. S., & Hondebrink, L. (2017). Measuring inhibition of monoamine reuptake transporters by new psychoactive substances (NPS) in real-time using a high-throughput, fluorescence-based assay. Toxicology in Vitro, 45(1), 60-71. https://doi.org/10.1016/j.tiv.2017.05.010
van Thriel, C., Levin, E., Lein, P., Costa, L. G., & Westerink, R. H. S. (2017). Neural mechanisms of functional impairment across the lifespan: The 15th Biennial Meeting of the International Neurotoxicology Association and 39th Annual Meeting of the Neurobehavioral Teratology Society. NeuroToxicology, 59, 131-132. https://doi.org/10.1016/j.neuro.2017.03.003
Kasteel, E. E. J., & Westerink, R. H. S. (2017). Comparison of the acute inhibitory effects of Tetrodotoxin (TTX) in rat and human neuronal networks for risk assessment purposes. Toxicology Letters, 270, 12-16. https://doi.org/10.1016/j.toxlet.2017.02.014
Hondebrink, L., Kasteel, E. E. J., Tukker, A. M., Wijnolts, F. M. J., Verboven, A. H. A., & Westerink, R. H. S. (2017). Neuropharmacological characterization of the new psychoactive substance methoxetamine. Neuropharmacology, 123, 1-9. https://doi.org/10.1016/j.neuropharm.2017.04.035
Aschner, M., Ceccatelli, S., Daneshian, M., Fritsche, E., Hasiwa, N., Hartung, T., Hogberg, H. T., Leist, M., Li, A., Mundi, W. R., Padilla, S., Piersma, A. H., Bal-Price, A., Seiler, A., Westerink, R. H., Zimmer, B., & Lein, P. J. (2017). Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use. Altex, 34(1), 49-74. https://doi.org/10.14573/altex.1604201
Heusinkveld, H. J., & Westerink, R. H. S. (2017). Comparison of different in vitro cell models for the assessment of pesticide-induced dopaminergic neurotoxicity. Toxicology in Vitro, 45(Pt 1), 81-88. https://doi.org/10.1016/j.tiv.2017.07.030
Duarte, D. J., Rutten, J. M. M., van den Berg, M., & Westerink, R. H. S. (2017). In vitro neurotoxic hazard characterization of different tricresyl phosphate (TCP) isomers and mixtures. NeuroToxicology, 59, 222-230. https://doi.org/10.1016/j.neuro.2016.02.001

2016

Scholarly publications

Zwartsen, A., Hondebrink, L., Verboven, A. H. A., Drega, S. W., Schmeink, S., de Groot, M. W. G. D. M., van Kleef, R. G. D. M., Wijnolts, F. M. J., de Groot, A., Meulenbelt, J., & Westerink, R. H. S. (2016). Micro-electrode array (MEA) recordings for neurotoxicity screening of new psychoactive substances (NPS). Toxicology Letters, 259, S207. https://doi.org/10.1016/j.toxlet.2016.07.496
Dingemans, M., Schütte, M. G., Wiersma, D. M. M., de Groot, A., van Kleef, G., Wijnolts, F., & Westerink, R. (2016). Chronic 14-day exposure to insecticides or methylmercury modulates neuronal activity in primary rat cortical cultures. NeuroToxicology, 57, 194-202. https://doi.org/10.1016/j.neuro.2016.10.002
Heusinkveld, H. J., van Vliet, A. C., Nijssen, P. C. G., & Westerink, R. H. S. (2016). In vitro neurotoxic hazard characterisation of dinitrophenolic herbicides. Toxicology Letters, 252, 62-69. https://doi.org/10.1016/j.toxlet.2016.04.014
Heusinkveld, H. J., Wahle, T., Campbell, A., Westerink, R. H. S., Tran, L., Johnston, H., Stone, V., Cassee, F. R., & Schins, R. P. F. (2016). Neurodegenerative and neurological disorders by small inhaled particles. NeuroToxicology, 56, 94-106. https://doi.org/10.1016/j.neuro.2016.07.007
Meulenberg, C. J. W., de Groot, A., Westerink, R. H. S., & Vijverberg, H. P. M. (2016). Organic solvent-induced changes in membrane geometry in human SH-SY5Y neuroblastoma cells - a common narcotic effect? NeuroToxicology, 55, 74-82. https://doi.org/10.1016/j.neuro.2016.05.013
Tukker, A. M., de Groot, M. W. G. D. M., Wijnolts, F. M. J., Kasteel, E. E. J., Hondebrink, L., & Westerink, R. H. S. (2016). Is the time right for in vitro neurotoxicity testing using human iPSC-derived neurons? Altex, 33(3), 261-71. https://doi.org/10.14573/altex.1510091
Hondebrink, L., Verboven, A. H. A., Drega, W. S., Schmeink, S., de Groot, M., van Kleef, R. G. D. M., Wijnolts, F. M. J., de Groot, A., Meulenbelt, J., & Westerink, R. H. S. (2016). Neurotoxicity screening of (illicit) drugs using novel methods for analysis of microelectrode array (MEA) recordings. NeuroToxicology, 55, 1-9. https://doi.org/10.1016/j.neuro.2016.04.020
de Groot, M. W. G. D. M., van Kleef, R. G. D. M., de Groot, A., & Westerink, R. H. S. (2016). In vitro developmental neurotoxicity following chronic exposure to 50 Hz extremely low frequency electromagnetic fields (ELF-EMF) in primary rat cortical cultures. Toxicological Sciences, 149(2), 433-440. https://doi.org/10.1093/toxsci/kfv242

2015

Scholarly publications

Hendriks, H. S., Koolen, L. A. E., Dingemans, M. M. L., Viberg, H., Lee, I., Leonards, P. E. G., Ramakers, G. M. J., & Westerink, R. H. S. (2015). Effects of neonatal exposure to the flame retardant tetrabromobisphenol-A, aluminum diethylphosphinate or zinc stannate on long-term potentiation and synaptic protein levels in mice. Archives of Toxicology, 89(12), 2345-2354. https://doi.org/10.1007/s00204-014-1366-8
Eubig, P. A., & Westerink, R. H. S. (2015). Introduction to special issue: Neurotoxicity of brominated flame retardants and the quest for safer alternatives. Neurotoxicology & Teratology, 52(Pt B), 118. https://doi.org/10.1016/j.ntt.2015.09.001
Hendriks, H. S., & Westerink, R. H. S. (2015). Neurotoxicity and risk assessment of brominated and alternative flame retardants. Neurotoxicology & Teratology, 52(Pt B), 248-269. https://doi.org/10.1016/j.ntt.2015.09.002
Hondebrink, L., Hermans, E. J. P., Schmeink, S., van Kleef, R. G. D. M., Meulenbelt, J., & Westerink, R. H. S. (2015). Structure-dependent inhibition of the human α1β2γ2 GABAA receptor by piperazine derivatives: A novel mode of action. NeuroToxicology, 51, 1-9. https://doi.org/10.1016/j.neuro.2015.09.002
Meijer, M., Brandsema, J. A. R., Nieuwenhuis, D., Wijnolts, F. M. J., Dingemans, M. M. L., & Westerink, R. H. S. (2015). Inhibition of voltage-gated calcium channels after subchronic and repeated exposure of PC12 cells to different classes of insecticides. Toxicological Sciences, 147(2), 607-617. https://doi.org/10.1093/toxsci/kfv154
de Ree, H., van den Berg, M., Brand, T., Mulder, G. J., Simons, R., Veldhuijzen van Zanten, B., & Westerink, R. H. S. (2015). Reply to letter to the editor, Judith Anderson commentary. NeuroToxicology, 46, 167-8. https://doi.org/10.1016/j.neuro.2014.12.014

Other output

Dingemans, M. M. L., Schutte, M. G., Wijnolts, F. M. J., van Kleef, R. G. D. M., de Groot, A., & Westerink, R. H. S. (2015). Acute And Chronic Exposure To Insecticides Modulates Electrical Activity And Spike Patterns Of Primary Cortical Cultures On Multi-Electrode Arrays. Abstract from Society of Toxicology Annual Meeting 2016, New Orleans, United States.
Dingemans, M. M. L., Wijnolts, F. M. J., Schutte, M. G., van Kleef, R. G. D. M., de Groot, A., & Westerink, R. H. S. (2015). Acute Insecticide-induced Changes in Electrical Activity of Primary Cortical Cultures: Multi-electrode Array Data Collection and Analysis. Poster session presented at Annual Meeting of the Dutch Society of Toxicology 2015, Soesterberg, Netherlands.

2014

Scholarly publications

Hendriks, H., Koolen, L., Dingemans, M., Viberg, H., Lee, I., Leonards, P. E. G., Ramakers, G. M. J., & Westerink, R. (2014). Effects of neonatal exposure to the flame retardant tetrabromobisphenol-A, aluminum diethylphosphinate or zinc stannate on long-term potentiation and synaptic protein levels in mice. Archives of Toxicology, 88. https://doi.org/10.1007/s00204-014-1366-8
Westerink, R. H. S. (2014). Reply on 'Prerequisites for a reliable introduction of in vitro neurotoxicity testing within the REACH framework'. NeuroToxicology, 44, 366. https://doi.org/10.1016/j.neuro.2014.06.004
Westerink, R. H. S. (2014). Modulation of cell viability, oxidative stress, calcium homeostasis, and voltage- and ligand-gated ion channels as common mechanisms of action of (mixtures of) non-dioxin-like polychlorinated biphenyls and polybrominated diphenyl ethers. Environmental science and pollution research international, 21(10), 6373-6383. https://doi.org/10.1007/s11356-013-1759-x
Nicolas, J., Hendriksen, P. J. M., van Kleef, R. G. D. M., de Groot, A., Bovee, T. F. H., Rietjens, I. M. C. M., & Westerink, R. H. S. (2014). Detection of marine neurotoxins in food safety testing using a multielectrode array. Molecular Nutrition & Food Research, 58(12), 2369-2378. https://doi.org/10.1002/mnfr.201400479
Llorens, J., van Thriel, C., Fox, D. A., Lammers, J., Westerink, R. H. S., & De Groot, D. M. G. (2014). Neurodevelopmental basis of health and disease: The 14th meeting of the International Neurotoxicology Association. NeuroToxicology, 43, 1-2. https://doi.org/10.1016/j.neuro.2014.03.014
Heusinkveld, H. J., van den Berg, M., & Westerink, R. H. S. (2014). In vitro dopaminergic neurotoxicity of pesticides: a link with neurodegeneration? Veterinary Quarterly, 34(3), 120-131. https://doi.org/10.1080/01652176.2014.980934
De Groot, D. M. G., Westerink, R. H. S., Lammers, J. H. C. M., Fox, D. A., van Thriel, C., & Llorens, J. (2014). Neurodevelopmental basis of health and disease: The 14th Meeting of the international neurotoxicology association. NeuroToxicology, 43, 143-159. https://doi.org/10.1016/j.neuro.2014.05.001
Gassmann, K., Schreiber, T., Dingemans, M. M. L., Krause, G., Roderigo, C., Giersiefer, S., Schuwald, J., Moors, M., Unfried, K., Bergman, Å., Westerink, R. H. S., Rose, C. R., & Fritsche, E. (2014). BDE-47 and 6-OH-BDE-47 modulate calcium homeostasis in primary fetal human neural progenitor cells via ryanodine receptor-independent mechanisms. Archives of Toxicology, 88(8), 1537-1548. https://doi.org/10.1007/s00204-014-1217-7
Litjens, R. P. W., Brunt, T. M., Alderliefste, G. J., & Westerink, R. H. S. (2014). Hallucinogen persisting perception disorder and the serotonergic system: A comprehensive review including new MDMA-related clinical cases. European Neuropsychopharmacology, 24(8), 1309-1323. https://doi.org/10.1016/j.euroneuro.2014.05.008
de Ree, H., van den Berg, M., Brand, T., Mulder, G. J., Simons, R., Veldhuijzen van Zanten, B., & Westerink, R. H. S. (2014). Health risk assessment of exposure to TriCresyl Phosphates (TCPs) in aircraft: A commentary. NeuroToxicology, 45, 209-15. https://doi.org/10.1016/j.neuro.2014.08.011
de Groot, M. W. G. D. M., & Westerink, R. H. S. (2014). Chemically-induced oxidative stress increases the vulnerability of PC12 cells to rotenone-induced toxicity. NeuroToxicology, 43, 102-9. https://doi.org/10.1016/j.neuro.2014.02.008
de Groot, M. W. G. D. M., Kock, M. D. M., & Westerink, R. H. S. (2014). Assessment of the neurotoxic potential of exposure to 50Hz extremely low frequency electromagnetic fields (ELF-EMF) in naïve and chemically stressed PC12 cells. NeuroToxicology, 44, 358-64. https://doi.org/10.1016/j.neuro.2014.07.009
de Groot, M. W. G. D. M., Dingemans, M. M. L., Rus, K. H., de Groot, A., & Westerink, R. H. S. (2014). Characterization of calcium responses and electrical activity in differentiating mouse neural progenitor cells in vitro. Toxicological Sciences, 137(2), 428-35. https://doi.org/10.1093/toxsci/kft261
Hendriks, H. S., Meijer, M., Muilwijk, M., van den Berg, M., & Westerink, R. H. S. (2014). A comparison of the in vitro cyto- and neurotoxicity of brominated and halogen-free flame retardants: prioritization in search for safe(r) alternatives. Archives of Toxicology, 88(4), 857-69. https://doi.org/10.1007/s00204-013-1187-1
Meijer, M., Hamers, T., & Westerink, R. H. S. (2014). Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for (sub)micromolar concentrations of organophosphate insecticides. NeuroToxicology, 43, 110-6. https://doi.org/10.1016/j.neuro.2014.01.008
Meijer, M., Dingemans, M. M. L., van den Berg, M., & Westerink, R. H. S. (2014). Inhibition of voltage-gated calcium channels as common mode of action for (mixtures of) distinct classes of insecticides. Toxicological Sciences, 141(1), 103-11. https://doi.org/10.1093/toxsci/kfu110
Meijer, M., Hendriks, H. S., Heusinkveld, H. J., Langeveld, W. T., & Westerink, R. H. S. (2014). Comparison of plate reader-based methods with fluorescence microscopy for measurements of intracellular calcium levels for the assessment of in vitro neurotoxicity. NeuroToxicology, 45C, 31-37. https://doi.org/10.1016/j.neuro.2014.09.001

2013

Scholarly publications

Solak, K. A., Wijnolts, F. M. J., Pralong, F. P., Blaauboer, B. J., van den Berg, M., Westerink, R. H. S., & van Duursen, M. B. M. (2013). In vitro neuroendocrine effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the AhR-expressing hypothalamic rat GnV-3 cell line. Toxicology, 311(3), 124-134. https://doi.org/10.1016/j.tox.2013.07.006
de Groot, M. W. G. D. M., Westerink, R. H. S., & Dingemans, M. M. L. (2013). Don't judge a neuron only by its cover: neuronal function in in vitro developmental neurotoxicity testing. Toxicological Sciences, 132(1), 1-7. https://doi.org/10.1093/toxsci/kfs269
Hondebrink, L., Tan, S., Hermans, E., van Kleef, R. G. D. M., Meulenbelt, J., & Westerink, R. H. S. (2013). Additive inhibition of human α1β2γ2 GABAA receptors by mixtures of commonly used drugs of abuse. NeuroToxicology, 35, 23-29. https://doi.org/10.1016/j.neuro.2012.12.003
Westerink, R. H. S. (2013). Do we really want to REACH out to in vitro? NeuroToxicology, 39, 169-172. https://doi.org/10.1016/j.neuro.2013.10.001
Waaijers, S. L., Kong, D., Hendriks, H. S., de Wit, C., Cousins, I. T., Westerink, R. H. S., Leonards, P. E. G., Kraak, M. H. S., Admiraal, W., de Voogt, P., & Parsons, J. R. (2013). Persistence, bioaccumulation, and toxicity of halogen-free flame retardants. Reviews of Environmental Contamination and Toxicology, 222, 1-71. https://doi.org/10.1007/978-1-4614-4717-7_1
Rijnierse, A., Kraneveld, A. D., Salemi, A., Zwaneveld, S., Goumans, A. P., Rychter, J., Thio, M., Redegeld, F. A. M., Westerink, R. H. S., & Kroese, A. B. A. (2013). Immunoglobulinfree light chains reduce in an antigen-specific manner the rate of rise of action potentials of mouse non-nociceptive dorsal root ganglion neurons. Journal of Neuroimmunology, 264(1-2), 14-23. http://www.ncbi.nlm.nih.gov/pubmed/24051200
Heusinkveld, H. J., Molendijk, J., van den Berg, M., & Westerink, R. H. S. (2013). Azole fungicides disturb intracellular Ca2+ in an additive manner in dopaminergic PC12 cells. Toxicological Sciences, 134(2), 374-381. https://doi.org/10.1093/toxsci/kft119

2012

Scholarly publications

Rietjens, S. J., Hondebrink, L., Westerink, R. H. S., & Meulenbelt, J. (2012). Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug-drug interactions. Critical Reviews in Toxicology, 42(10), 854-876. https://doi.org/10.3109/10408444.2012.725029
Vijverberg, H. P. M., & Westerink, R. H. S. (2012). Sense in Pb2+ sensing. Toxicological Sciences, 130(1), 1-3. https://doi.org/10.1093/toxsci/kfs221
Hendriks, H. S., van Kleef, R. G. D. M., van den Berg, M., & Westerink, R. H. S. (2012). Multiple novel modes of action involved in the in vitro neurotoxic effects of tetrabromobisphenol-A. Toxicological Sciences, 128(1), 235-246. https://doi.org/10.1093/toxsci/kfs136
van Thriel, C., Westerink, R. H. S., Beste, C., Bale, A. S., Lein, P. J., & Leist, M. (2012). Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts. NeuroToxicology, 33(4), 911-924. https://doi.org/10.1016/j.neuro.2011.10.002
Heusinkveld, H. J., & Westerink, R. H. S. (2012). Organochlorine insecticides lindane and dieldrin and their binary mixture disturb calcium homeostasis in dopaminergic PC12 cells. Environmental Science and Technology, 46(3), 1842-1848. https://doi.org/10.1021/es203303r
Hondebrink, L., Meulenbelt, J., Rietjens, S. J., Meijer, M., & Westerink, R. H. S. (2012). Methamphetamine, amphetamine, MDMA ('ecstasy'), MDA and mCPP modulate electrical and cholinergic input in PC12 cells. NeuroToxicology, 33(2), 255-260. https://doi.org/10.1016/j.neuro.2011.09.003
Westerink, R. H. S., Beekwilder, J. P., & Wadman, W. J. (2012). Differential alterations of synaptic plasticity in dentate gyrus and CA1 hippocampal area of Calbindin-D28K knockout mice. Brain Research, 1450, 1-10. https://doi.org/10.1016/j.brainres.2012.02.036
Hendriks, H. S., van Kleef, R. G. D. M., & Westerink, R. H. S. (2012). Modulation of human α4β2 nicotinic acetylcholine receptors by brominated and halogen-free flame retardants as a measure for in vitro neurotoxicity. Toxicology Letters, 213(2), 266-274. https://doi.org/10.1016/j.toxlet.2012.06.013
Langeveld, W. T., Meijer, M., & Westerink, R. H. S. (2012). Differential effects of 20 non-dioxin-like PCBs on basal and depolarization-evoked intracellular calcium levels in PC12 cells. Toxicological Sciences, 126(2), 487-496. https://doi.org/10.1093/toxsci/kfr346

Other output

Hondebrink, L., Rietjens, S. J., Westerink, R. H. S., & Meulenbelt, J. (2012). Pharmacokinetics and pharmacodynamics of 3,4‐methylenedioxymethamphetamine (MDMA): interindividual differences (due to polymorphisms and drug‐drug interactions) and opportunities for treatment interventions.. Poster session presented at Unknown event.
Hondebrink, L., van Kleef, R. G. D. M., van den Berg, M., Meulenbelt, J., & Westerink, R. H. S. (Accepted/In press). GABAA receptor: a novel mode of action of drugs of abuse.. Poster session presented at EUROTOX 2012, 49th congress of the European Societies of Toxicology, Stockholm, Zweden.

2011

Scholarly publications

Hondebrink, L., Meulenbelt, J., Meijer, M., van den Berg, M., & Westerink, R. H. S. (2011). High concentrations of MDMA ('ecstasy') and its metabolite MDA inhibit calcium influx and depolarization-evoked vesicular dopamine release in PC12 cells. Neuropharmacology, 61(1-2), 202-208. https://doi.org/10.1016/j.neuropharm.2011.03.028
Rychter, J., van Nassauw, L., Timmermans, J-P., Akkermans, L. M. A., Westerink, R. H. S., & Kroese, A. (2011). CGRP1 receptor activation induces piecemeal release of protease-1 from mouse bone marrow-derived mucosal mast cells. Neurogastroenterology and Motility, 23(2), e57-e68. https://doi.org/10.1111/j.1365-2982.2010.01617.x
Hondebrink, L., Meulenbelt, J., van Kleef, R. G. D. M., van den Berg, M., & Westerink, R. H. S. (2011). Modulation of human GABA(A) receptor function: A novel mode of action of drugs of abuse. NeuroToxicology, 32(6), 823-827. https://doi.org/10.1016/j.neuro.2011.05.016
Dingemans, M. M. L., van den Berg, M., & Westerink, R. H. S. (2011). Neurotoxicity of PBDEs: Dingemans et al. Respond. Environmental Health Perspectives, 119(8), a331-a332. https://doi.org/10.1289/ehp.1103907R
Stenberg, M., Hamers, T., Machala, M., Fonnum, F., Stenius, U., Lauy, A., van Duursen, M. B. M., & Westerink, R. H. S. (2011). Multivariate toxicity profiles and QSAR modeling of non-dioxin-like PCBs - An investigation of in vitro screening data from ultra-pure congeners. Chemosphere, 85(9), 1423-1429. https://doi.org/10.1016/j.chemosphere.2011.08.019
Heusinkveld, H. J., & Westerink, R. H. S. (2011). Caveats and limitations of plate reader-based high-throughput kinetic measurements of intracellular calcium levels. Toxicology and Applied Pharmacology, 255(1), 1-8. https://doi.org/10.1016/j.taap.2011.05.020
van Kempen, G. T. H., vanderLeest, H. T., Berg, RJ., Eilers, P., & Westerink, R. H. S. (2011). Three distinct modes of exocytosis revealed by amperometry in neuroendocrine cells. Biophysical Journal, 100(4), 968-977. https://doi.org/10.1016/j.bpj.2011.01.010
Dingemans, M. M. L., van den Berg, M., & Westerink, R. H. S. (2011). Neurotoxicity of brominated flame retardants: (in)direct effects of parent and hydroxylated polybrominated diphenyl ethers on the (developing) nervous system. Environmental Health Perspectives, 119(7), 900-907. https://doi.org/10.1289/ehp.1003035

2010

Scholarly publications

Antunes Fernandes, E. C., Hendriks, H. S., van Kleef, R. G. D. M., Reniers, A., Andersson, P. L., van den Berg, M., & Westerink, R. H. S. (2010). Activation and potentiation of human GABAA receptors by non-dioxin-like PCBs depends on chlorination pattern. Toxicological Sciences, 118(1), 183-190. https://doi.org/10.1093/toxsci/kfq257
Hendriks, H. S., Antunes Fernandes, E. C., Bergman, A., van den Berg, M., & Westerink, R. H. S. (2010). PCB-47, PBDE-47, and 6-OH-PBDE-47 differentially modulate human GABA A and alpha4beta2 nicotinic acetylcholine receptors. Toxicological Sciences, 118(2), 635-642. https://doi.org/10.1093/toxsci/kfq284
Heusinkveld, H. J., Thomas, G. O., Lamot, I., van den Berg, M., Kroese, A., & Westerink, R. H. S. (2010). Dual actions of lindane (γ-hexachlorocyclohexane) on calcium homeostasis and exocytosis in rat PC12 cells. Toxicology and Applied Pharmacology, 248(1), 12-19. https://doi.org/10.1016/j.taap.2010.06.013
Dingemans, M. M. L., Heusinkveld, H. J., Bergman, A., van den Berg, M., & Westerink, R. H. S. (2010). Bromination pattern of hydroxylated metabolites of BDE-47 affects their potency to release calcium from intracellular stores in PC12 cells. Environmental Health Perspectives, 118(4), 519-525. https://doi.org/10.1289/ehp.0901339
Adams, K. L., Maxson, M. M., Mellander, L., Westerink, R. H. S., & Ewing, A. G. (2010). Estradiol inhibits depolarization-evoked exocytosis in PC12 cells via N-type voltage-gated calcium channels. Cellular and Molecular Neurobiology, 30(8), 1235-1242. https://doi.org/10.1007/s10571-010-9570-4
Westerink, R. H. S., & Hondebrink, L. (2010). Are high-throughput measurements of intracellular calcium using plate-readers sufficiently accurate and reliable? Toxicology and Applied Pharmacology, 249(3), 247-248. https://doi.org/10.1016/j.taap.2010.09.014
Dingemans, M. M. L., van den Berg, M., Bergman, A., & Westerink, R. H. S. (2010). Calcium-related processes involved in the inhibition of depolarization-evoked calcium increase by hydroxylated PBDEs in PC12 cells. Toxicological Sciences, 114(2), 302-309. https://doi.org/10.1093/toxsci/kfp310
Hondebrink, L., Timmerman, J. T., van den Berg, M., Meulenbelt, J., & Westerink, R. H. S. (Accepted/In press). Effects of amphetamine on neurotransmitter release in PC12 and chromaffin cells.. S223. Abstract from XII International Congress of Toxicology, Barcelona, Spain.
Antunes Fernandes, E. C., Hendriks, H. S., van Kleef, R. G. D. M., van den Berg, M., & Westerink, R. H. S. (2010). Potentiation of the human GABA(A) receptor as a novel mode of action of lower-chlorinated non-dioxin-like PCBs. Environmental Science and Technology, 44(8), 2864-2869. https://doi.org/10.1021/es902321a

Professional publications

Fabriek, B., & Westerink, R. H. S. (2010). Super zout. Voedingsmiddelentechnologie, 12, 26-28.

Other output

Heusinkveld, H. J., Thomas, G. O., Lamot, I., van den Berg, M., Kroese, A. B. A., & Westerink, R. H. S. (Accepted/In press). Dual effects of lindane (gamma-hexachlorocyclohexane) on calcium homeostasis and exocytosis in rat PC12 cells.. S320. Abstract from XII International Congress of Toxicology, Barcelona, Spain.
Hondebrink, L., van den Berg, M., Meulenbelt, J., & Westerink, R. H. S. (Accepted/In press). Neurotoxicity of drugs of abuse.. Abstract from NVT PHD Day - Annual meeting of the Dutch Society of Toxicology, Woudschoten, Zeist, the Netherlands.
Westerink, R. H. S., Heusinkveld, H. J., Bergman, A., van den Berg, M., & Dingemans, M. M. L. (Accepted/In press). The brominated flame retardants hexabromocyclododecane (HBCD) and BDE-47 affect calcium homeostasis in rat PC12 cells.. S222-S223. Abstract from XII International Congress of Toxicology, Barcelona, Spain.

2009

Scholarly publications

Hondebrink, L., Meulenbelt, J., Timmerman, J. G., van den Berg, M., & Westerink, R. H. S. (2009). Amphetamine reduces vesicular dopamine content in dexamethasone-differentiated PC12 cells only following L-DOPA exposure. Journal of Neurochemistry, 111(2), 624-633.
Dingemans, M. M. L., Heusinkveld, H. J., de Groot, A., Bergman, A., van den Berg, M., & Westerink, R. H. S. (2009). Hexabromocyclododecane inhibits depolarization-induced increase in intracellular calcium levels and neurotransmitter release in PC12 cells. Toxicological Sciences, 107(2), 490-497.
https://dspace.library.uu.nl/bitstream/handle/1874/39279/Dingemans-Toxicol_Sci_2009_107_490-497.pdf?sequence=1

Other output

Andersson, P., Al-Anati, L., Stenius, U., Antunes Fernandes, E. C., van Duursen, M. B. M., Westerink, R. H. S., Fonnum, F., Wigestrand, M., Stenberg, M., & Hamers, T. (Accepted/In press). Classification of NDL-PCB congeners based on extnsive in vitro screening and multivariate statistics. S245-246. Abstract from Unknown event, Asilomar, USA.
Westerholm, E., Boix, J., Miettinen, H., de Roos, R., Antunes Fernandes, E. C., Westerink, R. H. S., van Duursen, M. B. M., Stenberg, M., Carreira, S., Machala, M., Silins, I., Stenius, U., Halldin, K., Hanberg, A., & Hakansson, H. (Accepted/In press). ATHON NDL-PCB effect database; A tool to facilitate the cumulative risk assessment of NDL-PCBs. S244-245. Abstract from Unknown event, Asilomar, USA.
Westerink, R. H. S. (2009). Organiser/host of the session: "Pharmacological and toxicological modulation of calcium signalling and exocytosis. Paper presented at 15th International symposium on chromaffin cell biology (ISCCB-15), Mérida, Yucatán, México.

2008

Scholarly publications

van Kleef, G., Vijverberg, H. P. M., & Westerink, R. H. S. (2008). Selective inhibition of human heteromeric α9α10 nicotinic acetylcholine receptors at a low agonist concentration by low concentrations of ototoxic organic solvents. Toxicology in Vitro, 22(6), 1568-1572. https://doi.org/10.1016/j.tiv.2008.06.007
Westerink, R. H. S., & Ewing, A. G. (2008). The PC12 cell as model for neurosecretion. Acta Physiologica, 192(2), 273-285.
Dingemans, M. M. L., de Groot, A., van Kleef, R. G., Bergman, A., van den Berg, M., Vijverberg, H. P. M., & Westerink, R. H. S. (2008). Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells. Environmental Health Perspectives, 116(5), 637-643.
https://dspace.library.uu.nl/bitstream/handle/1874/259626/Environ%2520Health%2520Persp%25202008%2520Dingemans.pdf?sequence=1
Bal-Price, A. K., Sunol, C., Weiss, D. G., van Vliet, E., Westerink, R. H. S., & Costa, L. G. (2008). Application of in vitro neurotoxicity testing for regulatory purposes: Symposium III summary and research needs. NeuroToxicology, 29(3), 520-531.

2007

Scholarly publications

Dingemans, M. M. L., Ramakers, G. M. J., Gardoni, F., van Kleef, R. G., Bergman, A., di Luca, M., van den Berg, M., Westerink, R. H. S., & Vijverberg, H. P. M. (2007). Neonatal exposure to brominated flame retardant BDE-47 reduces long-term potentiation and postsynaptic protein levels in mouse hippocampus. Environmental Health Perspectives, 115(6), 865-870.
https://dspace.library.uu.nl/bitstream/handle/1874/259625/Environ%2520Health%2520Persp%25202007%2520Dingemans.pdf?sequence=1

2006

Scholarly publications

Westerink, R. H. S., Rook, M. B., Beekwilder, J. P., & Wadman, W. J. (2006). Dual role of calbindin-D28K in vesicular catecholamine release from mouse chromaffin cells. Journal of Neurochemistry, 99(2), 628-640.
Westerink, R. H. S. (2006). Targeting exocytosis: ins and outs of the modulation of quantal dopamine release. CNS & Neurological Disorders-Drug Targets, 5(1), 57-77.
Westerink, R. H. S. (2006). Dopaminergic neurotransmission - Editorial. CNS & Neurological Disorders-Drug Targets, 5(1).

2004

Scholarly publications

Westerink, R. H. S., & Vijverberg, H. P. M. (2004). Modulation of Ca2+-independent, Pb2+-induced exocytosis from rat PC12 cells by CaMK II. In R. Borges, & L. Gandia (Eds.), Cell biology of the chromaffin cell (pp. 47-54). Instituto Teofilo Hernando.
https://dspace.library.uu.nl/bitstream/handle/1874/7455/Westerink%25202004%2520Cell_Biol_Chromaffin_Cell_47.pdf?sequence=2

2002

Scholarly publications

Westerink, R. H. S. (2002). Modulation of vesicular catecholamine release from rat PC12 cells.
Westerink, R. H. S. (2002). Modulation of vesicular catechloramine. Release from rat PC12 cells. Universiteit Utrecht.
Westerink, R. H. S., & Vijverberg, H. P. M. (2002). Vesicular catecholamine release from rat PC12 cells on acute and subchronic exposure to polychlorinated biphenyls. Toxicology and Applied Pharmacology, 183, 153-159.
https://dspace.library.uu.nl/bitstream/handle/1874/7464/Westerink%25202002%2520Toxicol_Appl_Pharmacol_183_153.pdf?sequence=2
Westerink, R. H. S., & Vijverberg, H. P. M. (2002). Toluene-induced, Ca2+-dependent vesicular catecholamine release in rat PC12 cells. Neuroscience Letters, 326, 81-84.
Westerink, R. H. S., Klompmakers, A. A., Westenberg, H. G. M., & Vijverberg, H. P. M. (2002). Signaling pathways involved in Ca2+- and Pb2+-induced vesicular catecholamine release from rat PC12 cells. Brain Research, 957, 25-36.
Westerink, R. H. S., & Vijverberg, H. P. M. (2002). Ca2+-independent vesicular catecholamine release in PC12 cells by nanomolar concentrations of Pb2+. Journal of Neurochemistry, 80, 861-873.
Vijverberg, H. P. M., Leinders-Zufall, T., & Westerink, R. H. S. (2002). Multiple, distinct actions of metal ions on cellular signal processes. Materialwissenschaft und Werkstofftechnik, 33, 751-755.
https://dspace.library.uu.nl/bitstream/handle/1874/7462/Vijverberg%25202002%2520Materialwissenschaft_33_751.pdf?sequence=2

Other output

Vijverberg, H. P. M., & Westerink, R. H. S. (2002). Ca2+-independent vesicular catecholamine release in PC12 cells. Paper presented at Unknown event, Asilomar, USA.

2000

Scholarly publications

Westerink, R. H. S., de Groot, A., & Vijverberg, H. P. M. (2000). Heterogeneity of catecholamine-containg vesicles in PC12 cells. Biochemical and Biophysical Research Communications, 270, 625-630.
https://dspace.library.uu.nl/bitstream/handle/1874/7468/Westerink%25202000%2520Biochem_Biophys_Res_Commun_270_625.pdf?sequence=2

1999

Scholarly publications

Peters, R. C., & Westerink, R. H. S. (1999). Catfish electroreceptor organ functioning during five days exposure to different calcium environments. Fish Physiology and Biochemistry, 21(1), 81-88.
https://dspace.library.uu.nl/bitstream/handle/1874/11746/westerink_99_Peterscatfish.pdf?sequence=2