Publications
2025
Scholarly publications
Zenclussen, A. C., Belmar Erilkin, V., Böhmert, L., Borilova Linhartova, P., Braeuning, A., Braun, G., Chevrier, C., Duijts, L., Escher, B. I., Felix, J., Gómez-Olarte, S., Guxens, M., Herberth, G., Hilscherova, K., Klanova, J., Kohl, Y., Krischak, K., Lagadic-Gossmann, D., Langouët, S., ... Warembourg, C. (2025). The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease. Open Research Europe, 4, Article 271. [DOI] [Portal]
Giustarini, G., Skrabanja, T. L. P., van den Berg, A. E. T., van Staveren, S., Vos, T., Zhou, Z. H., Klaessens, T., Mulder, E., Klazen, J., Smit, J., Pieters, R., Koenderman, L., & Vrisekoop, N. (2025). Polystyrene microplastics cross the murine intestine and induce inflammatory cell death after phagocytosis by human monocytes and neutrophils. iScience, 28(12), Article 114076. [DOI] [Portal]
Dirven, H., Bogusz, A., Bouwmeester, H., Busch, M., Duflos, G., Eriksen, G. S., Fardilha, M., Flores-Gomez, D., Franko, N., Gaté, L., Guichard, Y., Silva, M. J., Kamstra, J. H., Kasiotis, K. M., Kim, S., Kim, Y. J., Kim, Y., van der Koogh, E., Loureiro, S., ... Herzke, D. (2025). Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project. Frontiers in Toxicology, 7, Article 1719035. [DOI] [Portal]
Lenssen, E. S., Hoek, G., Scibetta, L., Skrabanja, T. L. P., Caiazzo, L., Vrisekoop, N., Lamoree, M., Vermeulen, R., & Pieters, R. H. H. (2025). Traffic-related micro- and nanoplastics in air increase total and differential white blood cell counts in healthy young adults. Environment International, 203, Article 109732. [DOI] [Portal]
van den Berg, A. E. T., Adriaans, K. J., Parker, L. A., Höppener, E. M., Dusza, H. M., Legler, J., & Pieters, R. H. H. (2025). Top-down generated micro- and nanoplastics reduce macrophage viability without eliciting a pro-inflammatory response. Microplastics and Nanoplastics, 5(1), Article 32. [DOI] [Portal]
Lenssen, E. S., Scibetta, L., Brits, M., Lamoree, M., Caiazzo, L., Montereali, M. R., Manzo, S., Chiavarini, S., Vermeulen, R., Pieters, R. H. H., & Hoek, G. (2025). Comparison of traffic-related micro- and nanoplastic concentrations at three urban locations. Atmospheric Environment, 355, Article 121257. [DOI] [Portal]
Kienhuis, A., Krul, C., van Engelen, J., Evelo, C. T., Hessel, E., Hoekman, J., Kramer, N., Krop, E., Masereeuw, R., Moors, E., Negro, S. O., Piersma, A., Pieters, R., Teunis, M., Willighagen, E., & Legler, J. (2025). The Virtual Human Platform for Safety Assessment (VHP4Safety) project: Next generation chemical safety assessment based on human data. Altex, 42(1), 111–120. [DOI] [Portal]
Professional publications
Muncke, J., Pieters, R., Ćirković Veličković, T., Hernández Bonilla, A., Morrison, M., Reuther, R., & Vermeulen, R. (2025). CUSP Research Roadmap 2026-2032: Informing and advising on the state of the art, gaps, and future needs in micro- and nanoplastic and health research in Europe. Zenodo. [DOI] [Portal]
2024
Scholarly publications
Snapkow, I., Smith, N. M., Arnesdotter, E., Beekmann, K., Blanc, E. B., Braeuning, A., Corsini, E., Sollner Dolenc, M., Duivenvoorde, L. P. M., Sundstøl Eriksen, G., Franko, N., Galbiati, V., Gostner, J. M., Grova, N., Gutleb, A. C., Hargitai, R., Janssen, A. W. F., Krapf, S. A., Lindeman, B., ... Barouki, R. (2024). New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals: a PARC (Partnership for the Assessment of Risk from Chemicals) project. Frontiers in Toxicology, 6, Article 1339104. [DOI] [Repository]
Corradi, M., Luechtefeld, T., de Haan, A. M., Pieters, R., Freedman, J. H., Vanhaecke, T., Vinken, M., & Teunis, M. (2024). The application of natural language processing for the extraction of mechanistic information in toxicology. Frontiers in Toxicology, 6, Article 1393662. [DOI] [Repository]
Kartaram, S. W., Teunis, M., van Norren, K., Smits, M., M’Rabet, L., Verschuren, M. C. M., Mohrmann, K., Garssen, J., Witkamp, R., & Pieters, R. (2024). Markers for Immunological Resilience: Effects of Moderate- and High-Intensity Endurance Exercise on the Kinetic Response of Leukocyte Subsets. Immuno, 4(1), 43-56. [DOI] [Repository]
Al Habobe, H., Haverkort, E. B., Nazmi, K., Van Splunter, A. P., Pieters, R. H. H., & Bikker, F. J. (2024). The impact of saliva collection methods on measured salivary biomarker levels. Clinica Chimica Acta, 552, 1-6. Article 117628. [DOI] [Repository]
De Hoop, A. M. S., Valkenet, K., Dronkers, J. J., Krul, C. A. M., Ruurda, J. P., Veenhof, C., & Pieters, R. H. H. (2024). Effects of exercise during chemo- or radiotherapy on immune markers - a systematic review. Oncology, 102(5), 425–440. [DOI] [Repository]
2023
Scholarly publications
Knipping, K., Kartaram, S. W., Teunis, M., Zuithoff, N. P. A., Buurman, N., M'Rabet, L., van Norren, K., Witkamp, R., Pieters, R., & Garssen, J. (2023). Salivary concentrations of secretory leukocyte protease inhibitor and matrix metallopeptidase-9 following a single bout of exercise are associated with intensity and hydration status. PLoS One, 18(11 November), Article e0291297. [DOI] [Repository]
Bhalla, D., Steijaert, M. N., Poppelaars, E. S., Teunis, M., van der Voet, M., Corradi, M., Dévière, E., Noothout, L., Tomassen, W., Rooseboom, M., Currie, R. A., Krul, C., Pieters, R., van Noort, V., & Wildwater, M. (2023). DARTpaths, an in silico platform to investigate molecular mechanisms of compounds. Bioinformatics, 39(1), 1-3. Article btac767. [DOI] [Repository]
2022
Scholarly publications
Corradi, M. P. F., de Haan, A. M., Staumont, B., Piersma, A. H., Geris, L., Pieters, R. H. H., Krul, C. A. M., & Teunis, M. A. T. (2022). Natural language processing in toxicology: Delineating adverse outcome pathways and guiding the application of new approach methodologies. Biomaterials and Biosystems, 7, Article 100061. [DOI]
van den Berg, A. E. T., Plantinga, M., Vethaak, D., Adriaans, K. J., Bol-Schoenmakers, M., Legler, J., Smit, J. J., & Pieters, R. H. H. (2022). Environmentally weathered polystyrene particles induce phenotypical and functional maturation of human monocyte-derived dendritic cells. Journal of Immunotoxicology, 19(1), 125-133. [DOI] [Repository]
Oost, M. J., Ijaz, A., van Haarlem, D. A., van Summeren, K., Velkers, F. C., Kraneveld, A. D., Venema, K., Jansen, C. A., Pieters, R. H. H., & Ten Klooster, J. P. (2022). Chicken-derived RSPO1 and WNT3 contribute to maintaining longevity of chicken intestinal organoid cultures. Scientific Reports, 12(1), 1-12. Article 10563. [DOI] [Repository]
Lenssen, E. S., Pieters, R. H. H., Nijmeijer, S. M., Oldenwening, M., Meliefste, K., & Hoek, G. (2022). Short-term associations between barbecue fumes and respiratory health in young adults. Environmental Research, 204(Part A), Article 111868. [DOI] [Repository]
2021
Scholarly publications
van der Voet, M., Teunis, M., Louter-van de Haar, J., Stigter, N., Bhalla, D., Rooseboom, M., Wever, K. E., Krul, C., Pieters, R., Wildwater, M., & van Noort, V. (2021). Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegans and other nematodes. Toxicology Research, 10(6), 1202-1210. [DOI] [Repository]
Klooster, J. P. T., Bol-Schoenmakers, M., van Summeren, K., van Vliet, A. L. W., de Haan, C. A. M., van Kuppeveld, F. J. M., Verkoeijen, S., & Pieters, R. (2021). Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine. Communications Biology, 4(1), 1-13. Article 631. [DOI] [Repository]
Kuper, C. F., Pieters, R. H. H., & van Bilsen, J. H. M. (2021). Nanomaterials and the Serosal Immune System in the Thoracic and Peritoneal Cavities. International Journal of Molecular Sciences, 22(5), 1-15. Article 2610. [DOI] [Repository]
2020
Scholarly publications
Kartaram, S. W., van Norren, K., Schoen, E., Teunis, M., Mensink, M., Verschuren, M., M'rabet, L., Besseling van der Vaart, I., Mohrmann, K., Wittink, H., Garssen, J., Witkamp, R. F., & Pieters, R. H. H. (2020). Kinetics of Physiological Responses as a Measure of Intensity and Hydration Status During Experimental Physical Stress in Human Volunteers. Frontiers in Physiology, 11(9), Article 1006. [DOI] [Repository]
Dekker, S. C., Kraneveld, A. D., van Dijk, J., Kalfagianni, A., Knulst, A. C., Lelieveldt, H., Moors, E. H. M., Müller, E., Pieters, R. H. H., Pieterse, C. M. J., Rosenkranz, S., Voesenek, L. A. C. J., & van Westen, A. C. M. (2020). Towards Healthy Planet Diets: A Transdisciplinary Approach to Food Sustainability Challenges. Global Challenges, 11(2), Article 21. [DOI] [Repository]
van Esch, B. C. A. M., van Bilsen, J. H. M., Gros- van Hest, M., Kleinjans, L., Belzer, C., Jeurink, P. V., Garssen, J., Smit, J. J., Pieters, R. H. H., & Knippels, L. M. J. (2020). A multi-center assessment to compare residual allergenicity of partial hydrolyzed whey proteins in a murine model for cow’s milk allergy – Comparison to the single parameter guinea pig model. Toxicology Letters, 333, 312-321. [DOI] [Repository]
Giustarini, G., Huppelschoten, S., Barra, M., Oppelt, A., Wagenaar, L., Weaver, R. J., Bol-Schoenmakers, M., Smit, J. J., van de Water, B., Klingmüller, U., & Pieters, R. H. H. (2020). The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicology and Applied Pharmacology, 391, Article 114915. [DOI] [Repository]
Villemin, C., Tranquet, O., Solé-Jamault, V., Smit, J. J., Pieters, R. H. H., Denery-Papini, S., & Bouchaud, G. (2020). Deamidation and Enzymatic Hydrolysis of Gliadins Alter Their Processing by Dendritic Cells in Vitro. Journal of Agricultural and Food Chemistry, 68(5), 1447-1456. [DOI] [Repository]
Weaver, R. J., Blomme, E. A., Chadwick, A. E., Copple, I. M., Gerets, H. H. J., Goldring, C. E., Guillouzo, A., Hewitt, P. G., Ingelman-Sundberg, M., Jensen, K. G., Juhila, S., Klingmüller, U., Labbe, G., Liguori, M. J., Lovatt, C. A., Morgan, P., Naisbitt, D. J., Pieters, R. H. H., Snoeys, J., ... Park, B. K. (2020). Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models. Nature Reviews. Drug Discovery, 19, 131–148. [DOI] [Repository]
2019
Scholarly publications
Lozano-Ojalvo, D., Benedé, S., Antunes, C. M., Bavaro, S. L., Bouchaud, G., Costa, A., Denery-Papini, S., Díaz-Perales, A., Garrido-Arandia, M., Gavrovic-Jankulovic, M., Hayen, S., Martínez-Blanco, M., Molina, E., Monaci, L., Pieters, R. H. H., Villemin, C., Wichers, H. J., Wróblewska, B., Willemsen, L. E. M., ... van Bilsen, J. H. M. (2019). Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies. Trends in Food Science and Technology, 85, 307-319. [DOI] [Repository]
Nešić, A., Čavić, M., Popović, M., Zlatanova, M., Pieters, R., Smit, J., & Gavrović-Jankulović, M. (2019). The Kiwifruit Allergen Act d 1 Activates NF-κB Signaling and Affects mRNA Expression of TJ Proteins and Innate Pro-Allergenic Cytokines. Biomolecules, 9(12). [DOI] [Repository]
Braber, S., Bol-Schoenmakers, M., Akbari, P., Jeurink, P. V., Graaff, P. D., Smit, J. J., Van Esch, B. C. A. M., Garssen, J., Fink-Gremmels, J., & Pieters, R. H. H. (2019). Allergic Sensitization to Whey in Mice Is Facilitated By the Mycotoxin Deoxynivalenol (DON). 75-76. Abstract from World allergy congress, Seoul, Korea, Republic of. [DOI]
Nešić, A., Stam, A., Čavić, M., Ten Klooster, J. P., Pieters, R., Smit, J., & Gavrović-Jankulović, M. (2019). Activation of epithelial cells by the major kiwifruit allergen Act d 1 in human and mouse-derived intestinal model. Journal of Functional Foods, 62, Article 103556. [DOI] [Repository]
Van Bilsen, J. H. M., Verschuren, L., Wagenaar, L., Vonk, M. M., Van Esch, B. C. A. M., Knippels, L. M. J., Garssen, J., Smit, J. J., Pieters, R. H. H., & Van Den Broek, T. J. (2019). A network-based approach for identifying suitable biomarkers for oral immunotherapy of food allergy. BMC Bioinformatics, 20(1), Article 206. [DOI] [Repository]
Wagenaar, L., Van Roest, M., Kruijssen, L. J. W., Simons, P. J., Boon, L., Vonk, M. M., Van Esch, B. C. A. M., Knippels, L. M. J., Garssen, J., Pieters, R. H. H., & Smit, J. J. (2019). Non-digestible oligosaccharides scFOS/lcFOS facilitate safe subcutaneous immunotherapy for peanut allergy. Clinical and Molecular Allergy, 17(1), Article 7. [DOI] [Repository]
Wagenaar, L., Bol-Schoenmakers, M. W. H. C., Giustarini, G., Garssen, J., Smit, J. J., & Pieters, R. H. H. (2019). Mouse strain differences in response to oral immunotherapy for peanut allergy. Immunity, inflammation and disease, 7(1), 41-51. [DOI] [Repository]
Giustarini, G., Vrisekoop, N., Kruijssen, L., Wagenaar, L., Van Staveren, S., Van Roest, M., Bleumink, R., Bol-Schoenmakers, M., Weaver, R. J., Koenderman, L., Smit, J., & Pieters, R. (2019). Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement. Toxicological Sciences, 167(2), 385-396. [DOI] [Repository]
Vonk, M. M., Blokhuis, B. R. J., Diks, M. A. P., Wagenaar, L., Smit, J. J., Pieters, R. H. H., Garssen, J., Knippels, L. M. J., & van Esch, B. C. A. M. (2019). Butyrate Enhances Desensitization Induced by Oral Immunotherapy in Cow's Milk Allergic Mice. Mediators of Inflammation, 2019, Article 9062537. [DOI] [Repository]
van der Kleij, H. P. M., Warmenhoven, H. J. M., van Ree, R., Versteeg, S. A., Pieters, R. H. H., Dreskin, S. C., Knulst, A. C., Hoffen, E. V., Opstelten, D. J. E., Koppelman, S. J., & Smit, J. J. (2019). Chemically modified peanut extract shows increased safety while maintaining immunogenicity. Allergy, 74(5), 986-995. [DOI] [Portal]
Kartaram, S., Mensink, M., Teunis, M., Schoen, E., Witte, G., Janssen Duijghuijsen, L., Verschuren, M., Mohrmann, K., M'Rabet, L., Knipping, K., Wittink, H., van Helvoort, A., Garssen, J., Witkamp, R., Pieters, R., & van Norren, K. (2019). Plasma citrulline concentration, a marker for intestinal functionality, reflects exercise intensity in healthy young men. Clinical Nutrition, 38(5), 2251-2258. [DOI] [Repository]
2018
Scholarly publications
Koppelman, S. J., Smits, M., Tomassen, M., de Jong, G. A. H., Baumert, J., Taylor, S. L., Witkamp, R., Veldman, R. J., Pieters, R., & Wichers, H. (2018). Release of Major Peanut Allergens from Their Matrix under Various pH and Simulated Saliva Conditions-Ara h2 and Ara h6 Are Readily Bio-Accessible. Nutrients, 10(9), Article E1281. [DOI] [Repository]
Ten Klooster, J. P., Sotiriou, A., Boeren, S., Vaessen, S., Vervoort, J., & Pieters, R. (2018). Type 2 diabetes-related proteins derived from an in vitro model of inflamed fat tissue. Archives of Biochemistry and Biophysics, 644, 81-92. [DOI] [Repository]
Villeneuve, D. L., Landesmann, B., Allavena, P., Ashley, N., Bal-Price, A., Corsini, E., Halappanavar, S., Hussell, T., Laskin, D., Lawrence, T., Nikolic-Paterson, D., Pallardy, M., Paini, A., Pieters, R., Roth, R., & Tschudi-Monnet, F. (2018). Representing the Process of Inflammation as Key Events in Adverse Outcome Pathways. Toxicological Sciences, 163(2), 346-352. [DOI] [Repository]
Wagenaar, L., Bol-Schoenmakers, M., Giustarini, G., Vonk, M. M., van Esch, B. C. A. M., Knippels, L. M. J., Garssen, J., Smit, J. J., & Pieters, R. H. H. (2018). Dietary Supplementation with Non-Digestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model. Molecular Nutrition & Food Research, 62(20), Article 1800369. [DOI] [Repository]
Perusko, M., van Roest, M., Stanic-Vucinic, D., Simons, P. J., Pieters, R., Velickovic, T. C., & Smit, J. J. (2018). Glycation of the Major Milk Allergen β-Lactoglobulin Changes its Allergenicity by Alterations in Cellular Uptake and Degradation. Molecular Nutrition & Food Research, 62(17), Article e1800341. [DOI] [Repository]
Giustarini, G., Kruijssen, L., van Roest, M., Bleumink, R., Weaver, R. J., Bol-Schoenmakers, M., Smit, J., & Pieters, R. (2018). Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin-induced tumor necrosis factor-dependent liver injury in mice. Journal of applied toxicology, 38(5), 753-765. [DOI] [Repository]
2017
Scholarly publications
Racz, P. I., Wildwater, M., Rooseboom, M., Kerkhof, E., Pieters, R., Yebra-Pimentel, E. S., Dirks, R. P., Spaink, H. P., Smulders, C., & Whale, G. F. (2017). Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds. Toxicology in Vitro, 44, 11-16. [DOI]
Hammerschmidt-Kamper, C., Biljes, D., Merches, K., Steiner, I., Daldrup, T., Bol-Schoenmakers, M., Pieters, R. H. H., & Esser, C. (2017). Indole-3-carbinol, a plant nutrient and AhR-Ligand precursor, supports oral tolerance against OVA and improves peanut allergy symptoms in mice. PLoS One, 12(6), 1-17. Article e0180321. [DOI] [Repository]
Vonk, M. M., Diks, M. A. P., Wagenaar, L., Smit, J. J., Pieters, R. H. H., Garssen, J., van Esch, B. C. A. M., & Knippels, L. M. J. (2017). Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model: A Potential Role for Foxp3+Regulatory T Cells. Frontiers in Immunology, 8, Article 1230. [DOI] [Repository]
Vonk, M. M., Wagenaar, L., Pieters, R. H. H., Knippels, L. M. J., Willemsen, L. E. M., Smit, J. J., van Esch, B. C. A. M., & Garssen, J. (2017). The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models. Clinical and Translational Allergy, 7(1), Article 35. [DOI], [DOI] [Repository]
van Bilsen, J. H. M., Sienkiewicz-Szłapka, E., Lozano-Ojalvo, D., Willemsen, L. E. M., Antunes, C. M., Molina, E., Smit, J. J., Wróblewska, B., Wichers, H. J., Knol, E. F., Ladics, G. S., Pieters, R. H. H., Denery-Papini, S., Vissers, Y. M., Bavaro, S. L., Larré, C., Verhoeckx, K. C. M., & Roggen, E. L. (2017). Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins. Clinical and Translational Allergy, 7(1), 13. [DOI] [Repository]
Vaessen, S. F. C., van Lipzig, M. M. H., Pieters, R. H. H., Krul, C. A. M., Wortelboer, H. M., & van de Steeg, E. (2017). Regional expression levels of drug transporters and metabolizing enzymes along the pig and human intestinal tract and comparison with Caco-2 cells. Drug Metabolism and Disposition, 45(4), 353-360. [DOI] [Repository]
JanssenDuijghuijsen, L. M., Keijer, J., Mensink, M., Lenaerts, K., Ridder, L., Nierkens, S., Kartaram, S. W., Verschuren, M. C. M., Pieters, R. H. H., Bas, R., Witkamp, R. F., Wichers, H. J., & van Norren, K. (2017). Adaptation of exercise-induced stress in well-trained healthy young men. Experimental Physiology, 102(1), 86-99. [DOI] [Repository]
Other output
Wagenaar, L., Vonk, M. M., Giustarini, G., Bol-Schoenmakers, M. W., Van Esch, B. C., Knippels, L. M., Garssen, J., Pieters, R. H., & Smit, J. J. (2017). Reducing allergic symptoms with oral immunotherapy supported by a non-digestible oligosaccharide supplemented diet in a peanut allergy mouse model. 724. [DOI]
2016
Scholarly publications
Wagenaar, L., Vonk, M. M., Van Roest, M., Kruijssen, L. J. W., Van Esch, B. C. A. M., Knippels, L. M. J., Garssen, J., Pieters, R. H. H., & Smit, J. J. (2016). Oral immunotherapy in combination with a non-digestible oligosaccharide supplemented diet in a peanut allergy mouse model. Allergy: European Journal of Allergy and Clinical Immunology, 71, 167. [DOI]
Te Velde, A. A., Bezema, T., van Kampen, A. H. C., Kraneveld, A. D., 't Hart, B. A., van Middendorp, H., Hack, E. C., van Montfrans, J. M., Belzer, C., Jans-Beken, L., Pieters, R. H., Knipping, K., Huber, M., Boots, A. M. H., Garssen, J., Radstake, T. R., Evers, A. W. M., Prakken, B. J., & Joosten, I. (2016). Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders. Frontiers in Immunology, 7, Article 587. [DOI] [Repository]
Kwast, L., Aida, T., Fiechter, D., Kruijssen, L., Bleumink, R., Boon, L., Ludwig, I., & Pieters, R. (2016). Immune responses induced by diclofenac or carbamazepine in an oral exposure model using TNP-Ficoll as reporter antigen. Journal of Immunotoxicology, 13(6), 918-926. [DOI] [Repository]
Vonk, M. M., Wagenaar, L., Smit, J. J., Pieters, R. H. H., Willemsen, L. E. M., Garssen, J., Van Esch, B. C. A. M., & Knippels, L. M. J. (2016). The combination of oral immunotherapy and a non-digestible oligosaccharide supplemented diet reduced allergic symptoms in a murine cow's milk allergy model. Allergy: European Journal of Allergy and Clinical Immunology, 71, 251. [DOI]
van der Wielen, N., Ten Klooster, J. P., Muckenschnabl, S., Pieters, R., Hendriks, H. F., Witkamp, R. F., & Meijerink, J. (2016). The Noncaloric Sweetener Rebaudioside A Stimulates Glucagon-Like Peptide 1 Release and Increases Enteroendocrine Cell Numbers in 2-Dimensional Mouse Organoids Derived from Different Locations of the Intestine. Journal of Nutrition, 146(12), 2429-35. [DOI] [Repository]
Poland, M., Ten Klooster, J. P., Wang, Z., Pieters, R., Boekschoten, M., Witkamp, R., & Meijerink, J. (2016). Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages. Biochimica et Biophysica Acta, 1861(12 Part A), 2020-2028. [DOI] [Repository]
Bøgh, K. L., van Bilsen, J., Głogowski, R., López-Expósito, I., Bouchaud, G., Blanchard, C., Bodinier, M., Smit, J., Pieters, R., Bastiaan-Net, S., de Wit, N., Untersmayr, E., Adel-Patient, K., Knippels, L., Epstein, M. M., Noti, M., Nygaard, U. C., Kimber, I., Verhoeckx, K., & O'Mahony, L. (2016). Current challenges facing the assessment of the allergenic capacity of food allergens in animal models. Clinical and Translational Allergy, 6, Article 21. [DOI] [Repository]
Kwast, L., Fiechter, D., Kruijssen, L., Bleumink, R., Ludwig, I., Bol-Schoenmakers, M., Smit, J., & Pieters, R. (2016). Oral exposure to immunostimulating drugs results in early changes in innate immune parameters in the spleen. Journal of Immunotoxicology, 13(4), 535-47. [DOI] [Repository]
Knipping, K., van Roest, M., Kruijssen, L., Smits, M., Teunis, M., Cox, L., de Jong, N., Simons, P. J., Boon, L., Teshima, R., Gros, M., Kegler, D., Garssen, J., Knippels, L. M. J., & Pieters, R. (2016). Intra- and inter-laboratory validation of an innovative huFcεRIα-RBL-2H3 degranulation assay for in vitro allergenicity assessment of whey hydrolysates. Toxicology in Vitro, 33, 317-324. [DOI] [Repository]
Bol-Schoenmakers, M., Braber, S., Akbari, P., de Graaff, P., van Roest, M., Kruijssen, L., Smit, J. J., van Esch, B. C. A. M., Jeurink, P. V., Garssen, J., Fink-Gremmels, J., & Pieters, R. H. H. (2016). The mycotoxin deoxynivalenol facilitates allergic sensitization to whey in mice. Mucosal Immunology. [DOI] [Repository]
2015
Scholarly publications
Vonk, M. M., Wagenaar, L., Diks, M. A. P., Hofman, G. A., Dingjan, G. M., Smit, J. J., Pieters, R. H. H., Willemsen, L. E. M., Garssen, J., Knippels, L. M. J., & Van Esch, B. C. A. M. (2015). Comparing oral and subcutaneous antigen-specific immunotherapy in a cow's milk allergy mouse model. 200. http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L72029063
Wagenaar, L., Vonk, M. M., Van Roest, M., Kruijssen, L. J. W., Knippels, L. M. J., Van Esch, B. C. A. M., Pieters, R. H. H., & Smit, J. J. (2015). Oral and subcutaneous immunotherapy in a peanut allergy mouse model. In Allergy: European Journal of Allergy and Clinical Immunology (pp. 200). (Allergy: European Journal of Allergy and Clinical Immunology; Vol. 70). http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L72029062
Jayasena, S., Smits, M., Fiechter, D., de Jong, A., Nordlee, J., Baumert, J., Taylor, S. L., Pieters, R. H., & Koppelman, S. J. (2015). Comparison of six commercial ELISA kits for their specificity and sensitivity in detecting different major peanut allergens. Journal of Agricultural and Food Chemistry, 63(6), 1849-55. [DOI] [Portal]
Smit, J. J., Pennings, M. T., Willemsen, K., van Roest, M., van Hoffen, E., & Pieters, R. H. (2015). Heterogeneous responses and cross reactivity between the major peanut allergens Ara h 1, 2,3 and 6 in a mouse model for peanut allergy. Clinical and Translational Allergy, 5(13). [DOI] [Repository]
Other output
Vonk, M. M., Wagenaar, L., Diks, M. A. P., Hofman, G. A., Dingjan, G. M., Smit, J. J., Pieters, R. H. H., Willemsen, L. E. M., Garssen, J., Knippels, L. M. J., & Van Esch, B. C. A. M. (2015). Comparing oral and subcutaneous antigen-specific immunotherapy in a cow's milk allergy mouse model. 200. [DOI]
Bol-Schoenmakers, M., Braber, S., Akbari, P., Jeurink, P., De Graaff, P., Smit, J. J., Van Esch, B., Garssen, J., Fink-Gremmels, J., & Pieters, R. H. H. (2015). The mycotoxin deoxynivalenol (DON) facilitates allergic sensitization to whey in mice. Allergy, 70, 17. [DOI]
2014
Scholarly publications
Van Esch, B. C. A. M., Van Bilsen, J. H. M., Van Gros-Hest, M., Jeurink, P. V., Garssen, J., Smit, J. J., Pieters, R. H. H., & Knippels, L. M. J. (2014). Allergenicity assessment of hydrolysed infant formulas; Comparison of a guinea pig and a mouse model for cow's milk allergy. Allergy, 69, 267. [DOI]
Stojadinovic, M., Pieters, R., Smit, J., & Velickovic, T. C. (2014). Cross-linking of β-lactoglobulin enhances allergic sensitization through changes in cellular uptake and processing. Toxicological Sciences, 140(1), 224-35. [DOI]
van den Elsen, L. W., Bol-Schoenmakers, M., van Esch, B. C., Hofman, G. A., van de Heijning, B. J., Pieters, R. H., Smit, J. J., Garssen, J., & Willemsen, L. E. (2014). DHA-Rich Tuna Oil Effectively Suppresses Allergic Symptoms in Mice Allergic to Whey or Peanut. Journal of Nutrition, 144(12), 1970-6. [DOI]
Teunis, M. A. T., Spiekstra, S. W., Smits, M., Adriaens, E., Eltze, T., Galbiati, V., Krul, C., Landsiedel, R., Pieters, R., Reinders, J., Roggen, E., Corsini, E., & Gibbs, S. (2014). International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity. Altex, 31(3), 251-68. [DOI]
Steenhof, M., Janssen, N. A. H., Strak, M., Hoek, G., Gosens, I., Mudway, I. S., Kelly, F. J., Harrison, R. M., Pieters, R. H. H., Cassee, F. R., & Brunekreef, B. (2014). Air pollution exposure affects circulating white blood cell counts in healthy subjects: the role of particle composition, oxidative potential and gaseous pollutants - the RAPTES project. Inhalation Toxicology, 26(3), 141-165. [DOI]
2013
Scholarly publications
Van Esch, B. C. A. M., Van Bilsen, J. H. M., Jeurink, P. V., Garssen, J., Verhoeckx, K. C. M., Smit, J. J., Pieters, R. H. H., & Knippels, L. M. J. (2013). Multicenter validation of a mouse model for cow's milk allergy to assess the allergenicity of hydrolysed cow's milk based infant formulae. Clinical and Translational Allergy, 3.
Steenhof, M., Mudway, I. S., Gosens, I., Hoek, G., Godri, K. J., Kelly, F. J., Harrison, R. M., Pieters, R. H. H., Cassee, F. R., Lebret, E., Brunekreef, B. A., Strak, M., & Janssen, N. A. H. (2013). Acute nasal pro-inflammatory response to air pollution depends on characteristics other than particle mass concentration or oxidative potential: the RAPTES project. Occupational and Environmental Medicine, 70(5), 341-8. [DOI]
van Esch, E. C. A. M., van Bilsen, J. H. M., Jeurink, P., Penninks, A. H., Smit, J. J., Pieters, R. H. H., Knippels, L. M., & Garssen, J. (2013). Interlaboratory evaluation of a cow's milk allergy mouse model to assess the allergenicity of hydrolysed cow's milk based infant formulas. Toxicology Letters, 220(1), 95-102. [DOI]
Kimber, I., & Pieters, R. (2013). Household chemicals, immune function, and allergy: A commentary. Journal of Immunotoxicology, 10(2), 169-172. [DOI]
Teunis, M., Corsini, E., Smits, M., Madsen, C., Eltze, T., Ezendam, J., Galbiati, V., Gremmer, E., Krul, C., Landin, A., Landsiedel, R., Pieters, R., Rasmussen, T. F., Reinders, J., Roggen, E., Spiekstra, S., & Gibbs, S. (2013). Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency. Toxicology in Vitro, 27(3), 1135-1150. [DOI]
Schulz, V. J., van Roest, M., Bol-Schoenmakers, M., van Duursen, M. B. M., van den Berg, M., Pieters, R. H. H., & Smit, J. J. (2013). Aryl hydrocarbon receptor activation affects the dendritic cell phenotype and function during allergic sensitization. Immunobiology, 218(8), 1055-1062. [DOI]
Switzar, L., Kwast, L. M., Lingeman, H., Giera, M., Pieters, R. H. H., & Niessen, W. M. A. (2013). Identification and quantification of drug-albumin adducts in serum samples from a drug exposure study in mice. Journal of chromatography. B, 917-918, 53-61. [DOI]
Schulz, V. J., Smit, J. J., & Pieters, R. H. H. (2013). The aryl hydrocarbon receptor and food allergy. Veterinary Quarterly, 33(2), 94-107. [DOI]
Other output
van Esch, E. C. A. M., van Bilsen, J., van Gros-Hest, M., Jeurink, P. V., Garssen, J., Smit, J. J., Pieters, R. H. H., & Knippels, L. M. (2013). Multicenter validation of a mouse model for cow's milk allergy to assess the allergenicity of hydrolysed cow's milk based infant formulas; phase III. 321-322. Poster session presented at Special Issue: Abstracts from the European Academy of Allergy and Clinical Immunology and World Allergy Organization World Allergy and Asthma.
2012
Scholarly publications
Schulz, V. J., Smit, J. J., Huijgen, V. C., Bol-Schoenmakers, M., van Roest, M., Kruijssen, L. W. J., Fiechter, D., Hassing, I., Bleumink, A. R. J., Safe, S., van Duursen, M. B. M., van den Berg, M., & Pieters, R. H. H. (2012). Non-dioxin-like AhR ligands in a mouse peanut allergy model. Toxicological Sciences, 128(1), 92-102. [DOI]
Schulz, V. J., Smit, J. J., Bol-Schoenmakers, M., van Duursen, M. B. M., van den Berg, M., & Pieters, R. H. H. (2012). Activation of the aryl hydrocarbon receptor reduces the number of precursor and effector T cells, but preserves thymic CD4(+)CD25(+)Foxp3(+) regulatory T cells. Toxicology Letters, 215(2), 100-109. [DOI]
2011
Scholarly publications
Bol-Schoenmakers, M., Bleumink, R., Marcondes Rezende, M., Mouser, E., Hassing, I., Ludwig, I. S., Smit, J. J., & Pieters, R. H. H. (2011). Diclofenac enhances allergic responses in a mouse peanut allergy model. Clinical and Experimental Allergy, 41(3), 424-433. [DOI]
Kwast, L. M., Fiechter, D., Hassing, I., Bleumink, R., Boon, L., Ludwig, I. S., & Pieters, R. H. H. (2011). Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA. Toxicological Sciences, 121(2), 312-319. [DOI]
Smit, J. J., Bol-Schoenmakers, M., Hassing, I., Fiechter, D., Boon, L., Bleumink, R., & Pieters, R. (2011). The role of intestinal dendritic cells subsets in the establishment of food allergy. Clinical and Experimental Allergy, 41(6), 890-898. [DOI]
Bezemer, G. F. G., Bauer, S. M., Oberdörster, G., Breysse, P. N., & Pieters, R. H. H. (2011). Activation of pulmonary dendritic cells and Th2-type inflammatory responses on instillation of engineered, environmental diesel emission source or ambient air pollutant particles in vivo. Journal of Innate Immunity, 3(2), 150-166. [DOI]
Marcondes Rezende, M., Hassing, I., Bol-Schoenmakers, M., Bleumink, R., Boon, L., van Bilsen, J., & Pieters, R. (2011). CD4(+) CD25(+) T regulatory cells do not transfer oral tolerance to peanut allergens in a mouse model of peanut allergy. Clinical and Experimental Allergy, 41(9), 1324-1333. [DOI]
Ahlem, C. N., Auci, D. L., Nicoletti, F., Pieters, R., Kennedy, M., Page, T. M., Reading, C. L., Enioutina, E. Y., & Frincke, J. (2011). Pharmacology and immune modulating properties of 5-androstene-3β,7β,17β-triol, a DHEA metabolite in the human metabolome. Journal of Steroid Biochemistry and Molecular Biology, 126(3-5), 87-94. [DOI]
Corsini, E., Oukka, M., Pieters, R., Kerkvliet, N. I., Ponce, R., & Germolec, D. (2011). Alterations in regulatory T-cells: Rediscovered pathways in immunotoxicology. Journal of Immunotoxicology, 8(4), 251-257. [DOI]
Smit, J. J., Willemsen, K., Hassing, I., Fiechter, D., Storm, G., van Bloois, L., Leusen, J. H. W., Pennings, M., Zaiss, D. M. W., & Pieters, R. H. H. (2011). Contribution of classic and alternative effector pathways in peanut-induced anaphylactic responses. PLoS One, 6(12), 10.1371/journal.pone.0028917. [DOI]
Schulz, V. J., Smit, J. J., Willemsen, K. J., Fiechter, D., Hassing, I., Bleumink, R., Boon, L., van den Berg, M., van Duursen, M. B. M., & Pieters, R. H. H. (2011). Activation of the aryl hydrocarbon receptor suppresses sensitization in a mouse peanut allergy model. Toxicological Sciences, 123(2), 491-500. [DOI]
Bol-Schoenmakers, M., Marcondes Rezende, M., Boon, L., Man, S., Hassing, I., Fiechter, D., Pieters, R. H. H., & Smit, J. J. (2011). Regulation by intestinal γδ T cells during establishment of food allergic sensitization in mice. Allergy, 66(3), 331-340. [DOI]
2010
Scholarly publications
Ludwig, I. S., Kwast, L. M., Fiechter, D., & Pieters, R. H. H. (2010). An in vivo tiered approach to test immunosensitization by low molecular weight compounds. Methods in Molecular Biology, 598(Part 2), 27-37. [DOI]
Conrad, D., Wang, A., Pieters, R., Nicoletti, F., Mangano, K., van Heeckeren, A., White, S. K., Frincke, J., Reading, C. L., Stickney, D., & Auci, D. L. (2010). HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression. Journal of Inflammation (BioMed Central), 7, Article 7:52. [DOI] [Repository]
Fecek, R., Marcondes Rezende, M., Busche, R., Hassing, I., Pieters, R., & Cuff, C. F. (2010). Enteric reovirus infection stimulates peanut-specific IgG2a responses in a mouse food allergy model. Immunobiology, 215(12), 941-948. [DOI]
Carfi', M., Bowe, G., Ferrario, D., Pieters, R., & Gribaldo, L. (2010). Maintenance and characterization of lymphocytes in human long term bone marrow cultures to study immunotoxicity. Toxicology in Vitro, 24(5), 1395-1403. [DOI]
Carfi', M., Bowe, G., Pieters, R., & Gribaldo, L. (2010). Selective inhibition of B lymphocytes in TBTC-treated human bone marrow long-term culture. Toxicology, 276(1), 33-40. [DOI]
Bol-Schoenmakers, M., Fiechter, D., Raaben, W., Hassing, I., Bleumink, R., Kruijswijk, D., Maijoor, K., Tersteeg-Zijderveld, M., Brands, R., & Pieters, R. (2010). Intestinal alkaline phosphatase contributes to the reduction of severe intestinal epithelial damage. European Journal of Pharmacology, 633(1-3), 71-77. [DOI]
Pieters, R., & Ludwig, I. S. (2010). Chemically Induced Allergy and Autoimmunity. In C. A. McQueen (Ed.), Comprehensive Toxicology, volume 5 (pp. 361-374). Academic Press.
2009
Scholarly publications
Nicoletti, F., Conrad, D., Wang, A., Pieters, R., Mangano, K., van Heeckeren, A., White, S. K., Frincke, J., Reading, C. L., Auci, D. L., & Stickney, D. (2009). 16alpha-Bromoepiandrosterone (HE2000) limits non-productive inflammation and stimulates immunity in lungs. Clinical and Experimental Immunology, 158(3), 308-316. [DOI]
Offner, H., Firestein, G. S., Boyle, D. L., Pieters, R., Frincke, J., Garsd, A., White, S. K., Reading, C. L., & Auci, D. L. (2009). An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis. Journal of Pharmacology and Experimental Therapeutics, 329(3), 1100-1109. [DOI]
2008
Scholarly publications
Carfi', M., Croera, C., Ferrario, D., Campi, V., Bowe, G., Pieters, R. H. H., & Gribaldo, L. (2008). TBTC induces adipocyte differentiation in human bone marrow long term culture. Toxicology, 249(1), 11-18.
de Haar, C., Kool, M., Hassing, I., Bol-Schoenmakers, M., Lambrecht, B. N., & Pieters, R. H. H. (2008). Lung dendritic cells are stimulated by ultrafine particles and play a key role in particle adjuvant activity. Journal of Allergy and Clinical Immunology, 121(5), 1246-1254.
de Jonge, J. D., Ezendam, J., Knippels, L. M. J., Penninks, A. H., Pieters, R., & van Loveren, H. (2008). Lactobacillus casei Shirota does not decrease the food allergic response to peanut extract in Brown Norway rats. Toxicology, 249(2-3), 140-145.
2007
Scholarly publications
van Wijk, F., Wehrens, E. J. M., Nierkens, S., Boon, L., Kasran, A., Pieters, R., & Knippels, L. M. (2007). CD4+CD25+ T cells regulate the intensity of hypersensitivity responses to peanut, but are not decisive in the induction of oral sensitization. Clinical and Experimental Allergy, 37(4), 572-581.
Carfi', M., Gennari, A., Malerba, I., Corsini, E., Pallardy, M., Pieters, R., van Loveren, H., Vohr, H. W., Hartung, T., & Gribaldo, L. (2007). In vitro tests to evaluate immunotoxicity: a preliminary study. Toxicology, 229(1-2), 11-22.
van Wijk, F., Nierkens, S., de Jong, W., Wehrens, E. J. M., Boon, L., van Kooten, P., Knippels, L. M., & Pieters, R. (2007). The CD28/CTLA-4-B7`signaling pathway is involved in both allergic sensitization and tolerance induction to orally administered peanut proteins. Journal of Immunology, 178(11), 6894-900.
Pieters, R. H. H. (2007). Detection of autoimmunity by pharmaceuticals. Methods, 41(1), 112-117.
de Jonge, J. D., Ezendam, J., Knippels, L. M., Odink, J., Pourier, M. S., Penninks, A. H., Pieters, R., & van Loveren, H. (2007). Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in brown Norway rats. Toxicology, 239(1-2), 68-76.
Pieters, R. H. H., & Nierkens, S. (2007). Experimental Models of Autoimmunity. In R. W. Luebke, R. V. House, & Kimber, Ian (Eds.), Immunotoxicology and Immunopharmacology. (pp. 469-485). (3rd edition). CRC Press.
2006
Scholarly publications
de Haar, C. G., Hassing, I., Bol, M. W. H. C., Bleumink, R., & Pieters, R. H. H. (2006). Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co-administered antigen in mice. Clinical and Experimental Allergy, 36(11), 1469-1479.
2005
Scholarly publications
Nierkens, S., Aalbers, M., Bol, M. W. H. C., van Wijk, F., Hassing, G. A. M., & Pieters, R. H. H. (2005). Development of an oral exposure mouse model to predict drug-induced hypersensitivity reactions by using reporter antigens. Toxicological Sciences, 83, 273-281.
Ezendam, J., Kosterman, K., Spijkerboer, H., Bleumink, A. R. J., Hassing, G. A. M., van Rooijen, N., Vos, J. G., & Pieters, R. H. H. (2005). Macrophages are involved in hexachlorobenzene-induced adverse immune effects. Toxicology and Applied Pharmacology, 209, 19-27.
Nygaard, U. C., Alberg, T., Bleumink, A. R. J., Aase, A., Dybing, E., Pieters, R., & Lovik, M. (2005). Ambient air particles from four European cities increase the primary cellular response to allergen in the draining lymph node. Toxicology, 207, 241-254.
van Wijk, F., Nierkens, S., Hassing, G. A. M., Feijen, M., Koppelman, S. J., Jong, G. A. H., Pieters, R. H. H., & Knippels, L. M. (2005). The effect of the food matrix on in vivo immune responses to purified peanut allergens. Toxicological Sciences, 86(2), 333-341.
Ezendam, J., Vos, J. G., & Pieters, R. H. H. (2005). Mechanisms of hexachlorobenzene-induced adverse effects in brown norway rats. Journal of Immunology, 1, 167-175.
Nierkens, S., Aalbers, M., Bol, M. W. H. C., Bleumink, A. R. J., van Kooten, P. J., Boon, L., & Pieters, R. H. H. (2005). Differential requirement for CD28/CTLA-4-CD80/CD86 interactions in drug-induced type 1 and type 2 immune response tot trinitrophenyl-ovalbumin. Journal of Immunology, 175, 3707-3714.
Nierkens, S., Bleumink, A. R. J., Bol-Schoenmakers, M., Hassing, G. A. M., van Rooijen, N., & Pieters, R. H. H. (2005). The reactive D-glucopyranose moiety of streptozotocin is responsible for activation of macrophages and subsequent stimulation of CD8+ T cells. Chemical Research in Toxicology, 18, 872-879.
Gennari, A., Ban, M., Braun, A., Casati, S., Corsini, E., Dastych, J., Descotes, J., Hartung, T., Hooghe-Peters, R., House, R., Pallardy, M., Pieters, R. H. H., Reid, L., & Tryphonas, H. (2005). The use of in vitro systems for evaluating immunotoxicity: the report and recommendations of an ECVAM workshop. Journal of Immunotoxicology, 2, 61-83.
de Haar, C. G., Hassing, G. A. M., Bol-Schoenmakers, M., Bleumink, A. R. J., & Pieters, R. H. H. (2005). Ultrafine carbon black particles cause early airway inflammation and have adjuvant activity in a mouse allergic airway disease model. Toxicological Sciences, 87(2), 409-418.
Weaver, J. L., Chapdelaine, J. M., Descotes, J., Germolec, D., Holsapple, M., House, R., Lebrec, H., Meade, J., Pieters, R. H. H., Hastings, K. L., & Dean, J. H. (2005). Evaluation of a lymph node proliferation assay for its ability to detect pharmaceuticals with potential to cause immune-mediated drug reactions. Journal of Immunotoxicology, 2, 11-20.
Nierkens, S., Aalbers, M., Bleumink, A. R. J., Boon, L., & Pieters, R. H. H. (2005). Drug-induced type 1 and type 2 immune responses are characterized by distinct profiles of cell kinetics, cytokine production, and expression of co-stimulatory molecules in the popliteal lymph node assay. Journal of Immunotoxicology, 2, 141-150.
Nierkens, S., & Pieters, R. H. H. (2005). Murine models of drug hypersensitivity. Current Opinion in Allergy and Clinical Immunology, 5, 331-335.
2004
Scholarly publications
Ezendam, J., Vos, J. G., & Pieters, R. (2004). Letter to the editor: Toxicological Sciences. Toxicological Sciences, 81, 254-255.
Ezendam, J., Hassing, G. A. M., Bleumink, A. R. J., Vos, J. G., & Pieters, R. H. H. (2004). Hexachlorobenzene-induced immunopathology in brown Norway rats is partly mediated by T cells. Toxicological Sciences, 78, 88-95.
Ezendam, J., Staedtler, F., Pennings, J., Vandebriel, R. J., Pieters, R. H. H., Boffetta, P., Harleman, J. H., & Vos, J. G. (2004). Toxicogenomics of subchronic hexachlorobenzene exposure in Brown Norway rats. Environmental Health Perspectives, 112, 782-791.
van Wijk, F., Hartgring, S. A. Y., Koppelman, S. J., Pieters, R. H. H., & Knippels, L. M. (2004). Mixed antibody and T cell responses to peanut and the peanut allergens Ara h 1, Ara h 2, Ara h 3 and Ara h 6 in an oral sensitization model. Clinical and Experimental Allergy, 34, 1422-1428.
Nierkens, S., Nieuwenhuijsen, L., Thomas, M., & Pieters, R. H. H. (2004). Evaluation of the use of reporter antigens in an auricular lymph node assay to assess the immunosensitizing potential of drugs. Toxicological Sciences, 79, 90-97.
Popovic, M., Nierkens, S., Pieters, R., & Uetrecht, J. (2004). Investigating the role of 2-phenylpropenal in felbamate-induced idiosyncratic drug reactions. Chemical Research in Toxicology, 17, 1568-1576.
2003
Scholarly publications
Albers, R., Bol-Schoenmakers, M., Bleumink, A. R. J., Willems, A. A., & Pieters, R. H. H. (2003). Effects of supplementation with vitamins A, C, and E, selenium, and zinc on immune function in a murine sensitization model. Nutrition, 19, 940-946.
Ezendam, J., Vissers, I., Bleumink, R., Vos, J. G., & Pieters, R. H. H. (2003). Immunomodulatory effects of tetrachlorobenzoquinone, a reactive metabolite of hexachlorobenzene. Chemical Research in Toxicology, 16, 688-694.
Pieters, R. H. H., Ezendam, J., & Nierkens, S. (2003). Chemical-specific properties co-determine the type of adverse immune response. Autoimmunity Reviews, 2, 25-29.
Professional publications
Nieuwenhuizen, W. F., Pieters, R. H. H., Knippels, L. M., Jansen, M. C. J. F., & Koppelman, S. J. (2003). Is candida albicans a trigger in the onset of coeliac disease. The Lancet, 361, 2152-2154.
2002
Scholarly publications
Gennari, A., Bol, M. W. H. C., Seinen, W., Penninks, A., & Pieters, R. (2002). Organotin-induced apoptosis occurs in small CD4(+)CD8(+) thymocytes and is accompanied by an increase in RNA synthesis. Toxicology, 175, 191-200.
Albers, R., Bol, M. W. H. C., Bleumink, R., Willems, A., Blonck, C., & Pieters, R. (2002). Effects of dietary lipids on immune function in a murine sensitisation model. British Journal of Nutrition, 88, 291-299.
Nierkens, S., van Helden, P., Bol, M. W. H. C., Bleumink, R., van Kooten, P., Ramdien-Murli, S., Boon, L., & Pieters, R. (2002). Selective requirement for CD40-CD154 in drug-induced type 1 versus type 2 responses to trinitrophenyl-ovalbumin. Journal of Immunology, 168(8), 3747-3754.
Gennari, A., Bleumink, R., Viviani, B., Galli, C. L., Marinovich, M., Pieters, R., & Corsini, E. (2002). Identification by DNA macroarray of nur77 as a gene induced by di-n-butyltin dichloride: its role in organotin-induced apoptosis. Toxicology and Applied Pharmacology, 181, 27-31.
Eisenbrand, G., Pool-Zobel, B., Baker, V., Balls, M., Blaauboer, B. J., Boobis, A., Carere, A., Kevekordes, S., Lhuguenot, J. C., Pieters, R., & Kleiner, J. (2002). Methods of in vitro toxicology. Food and Chemical Toxicology, 40, 193-236.
Pieters, R., Ezendam, J., Bleumink, R., Bol, M. W. H. C., & Nierkens, S. (2002). Predictive testing for autoimmunity. Toxicology Letters, 127, 83-91.
2001
Scholarly publications
Pieters, R. (2001). The popliteal lymph node assay: a tool for predicting drug allergies. Toxicology, 158, 65-69.
van Zijverden, M., de Haar, C. G., van Beelen, A. J., van Loveren, H., Penninks, A. H., & Pieters, R. (2001). Coadministration of Antigen and Particles Optimally Stimulates the Immune Response in an Intranasal Administration Model in Mice. Toxicology and Applied Pharmacology, 177, 174-178.
2000
Scholarly publications
van Zijverden, M., van der Pijl, A., Bol, M. W. H. C., van Pinxteren, F. A., de Haar, C. G., Penninks, A. H., van Loveren, H., & Pieters, R. (2000). Diesel exhaust, carbon black, and silica particles display distinct Th1/Th2 modulating activity. Toxicology and Applied Pharmacology, 168, 131-139.
Pieters, R. (2000). The popliteal lymph node assay in predictive testing for autoimmunity. Toxicology Letters, 112, 453-459.
Gennari, A., Viviani, B., Lodovico Galli, C., Marinovich, M., Pieters, R., & Corsini, E. (2000). Organotins induce apoptosis by disturbance of [Ca2+] i and mitochondrial activity, causing oxidative stress and activation of caspases in rat thymocytes. Toxicology and Applied Pharmacology, 169, 185-190.
Professional publications
Nierkens, S., van Helden, P. M. W., Bleumink, A. R. J., van Kooten, P. J., Boon, L., & Pieters, R. H. H. (2000). The role of CD40-CD40L interaction in Th1- and Th2-like immunostimulation caused by pharmaceuticals. Immunobiology, 203, 573-574.