prof. dr. P.R. (René) van Weeren
Gegenereerd op 2017-11-20 07:07:43


Chair
Equine Musculoskeletal Biology
Date of appointment 01.05.2007
Inaugural lecture date 14.04.2008
Profile

The drive for René van Weeren to become a vet probably originates from the family holidays he enjoyed as a kid in a rural region in the eastern part of the Netherlands ("De Achterhoek") in the 1960s, where he participated for years in the activities of the small-scale farming of those days. The red line in his career, a broad interest for research with focus on international collaboration, may stem from the inspiring and intellectually challenging environment of the high school he attended (St. Francis High School, Rotterdam) and the experiences of his 7-month stay in Mozambique as a final year student.

After many years of clinical activities as first a large animal surgeon and later an exclusively equine surgeon, René van Weeren is now almost exclusively occupied by research activities and the supervision of PhD students, apart from administrative duties. Special areas of interest are the influences of exercise on the (development of) the musculoskeletal system, research on joint homeostasis and cartilage regeneration, tendons and biomechanics. He enjoys working in these areas within a translational framework togther with the colleagues from human medicine and as part of large (international) collaborative networks. He is of the opinion that in these activities the coaching of young people and helping them to find develop themselves as critical, independent and truly academic researchers is the most rewarding aspect. Being a rather prolific writer himself, he likes the editing of papers and he is also an avid reader of "real" (i.e. non-scientific) literature. 

Gegenereerd op 2017-11-20 07:07:43
Curriculum vitae

Paul René van Weeren (1957) graduated in 1983 from the Utrecht University Veterinary Faculty (The Netherlands). He became a staff member of the Department of General and Large Animal Surgery in that year and obtained his PhD degree in 1989. From 1991-1993 he worked as a visiting professor at the Escuela de Medicina Veterinaria of the Universidad Nacional in Heredia, Costa Rica. He became a diplomate of the European College of Veterinary Surgeons in 1994. He was appointed as full professor to the Chair of Equine Musculoskeletal Biology in 2007 and is now mainly involved in research with focus areas articular cartilage, tendons and biomechanics. He became Head of the Department of Equine Sciences of the Faculty of Veterinary Medicine of Utrecht University in 2012.

René van Weeren has been a supervisor of 27 PhD students, who have obtained their degree in the past years and currently supervises 10 PhD students, who will be graduating within the next few years. He is an associate editor of Equine Veterinary Journal, member of the editorial board of The Veterinary Journal, and member of the scientific board of several others. He has been, or is, guest editor of various Special Issues or Supplements of a variety of scientific journals. He has been external examiner for PhD students abroad at various occasions in Belgium, the UK, France, Austria, Sweden, Norway and Finland. He is author or co-author of more than 250 peer-reviewed scientific publications and has contributed various chapters to a variety of text books.  

Gegenereerd op 2017-11-20 07:07:43
All publications
  Articles - 2017
Sandker, Maria J., Duque, Luisa F., Redout, Everaldo M., Chan, Alan, Que, Ivo, Löwik, Clemens W G M, Klijnstra, Evelien C., Kops, Nicole, Steendam, Rob, van Weeren, René, Hennink, Wim E. & Weinans, Harrie (15.01.2017). Degradation, intra-articular retention and biocompatibility of monospheres composed of [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers. Acta Biomaterialia, 48, (pp. 401-414) (14 p.).
Geburek, Florian, Roggel, Florian, van Schie, Hans T M, Beineke, Andreas, Estrada, Roberto, Weber, Kathrin, Hellige, Maren, Rohn, Karl, Jagodzinski, Michael, Welke, Bastian, Hurschler, Christof, Conrad, Sabine, Skutella, Thomas, van de Lest, Chris, van Weeren, René & Stadler, Peter M (05.06.2017). Effect of single intralesional treatment of surgically induced equine superficial digital flexor tendon core lesions with adipose-derived mesenchymal stromal cells - a controlled experimental trial. Stem Cell Research and Therapy, 8 (1), (pp. 129).
Groen, Wilhelmina Margaretha, Diloksumpan, Paweena, van Weeren, Paul René, Levato, Riccardo & Malda, Jos (16.06.2017). From intricate to integrated - Biofabrication of articulating joints. Journal of Orthopaedic Research © 2017 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc..
te Moller, N.C.R. & van Weeren, P.R. (2017). How exercise influences equine joint homeostasis. Veterinary Journal, 222, (pp. 60-67) (8 p.).
Gorissen, Ben, Wolschrijn, C F, Serra Bragança, F M, Geerts, A A J, Leenders, W O J L, Back, W & van Weeren, P R (2017). The development of locomotor kinetics in the foal and the effect of osteochondrosis. Equine veterinary journal. Supplement, 49 (4), (pp. 467-474). This article is protected by copyright. All rights reserved..
Serra Braganca, Filipe, Bosch, S, Voskamp, J P, Marin-Perianu, M, Van der Zwaag, B J, Vernooij, J C M, van Weeren, P R & Back, W (2017). Validation of distal limb mounted inertial-measurement-unit sensors for stride detection in Warmblood horses at walk and trot. Equine veterinary journal. Supplement, 49 (4), (pp. 545–551). This article is protected by copyright. All rights reserved..
  Articles - 2016
Bertholle, Christian P, Meijer, Ellen, Back, Wim, Stegeman, Arjan, van Weeren, P René & van Nes, Arie (31.03.2016). A longitudinal study on the performance of in vivo methods to determine the osteochondrotic status of young pigs. BMC Veterinary Research, 12.
Cokelaere, Stefan, Malda, Jos & van Weeren, René (2016). Cartilage defect repair in horses - Current strategies and recent developments in regenerative medicine of the equine joint with emphasis on the surgical approach. Veterinary Journal, 214, (pp. 61-71). Copyright © 2016 Elsevier Ltd. All rights reserved..
Ploeg, M, Gröne, A, van de Lest, C H A, Saey, V, Duchateau, L, Wolsein, P, Chiers, K, Ducatelle, R, van Weeren, P R, de Bruijn, M & Delesalle, C (16.11.2016). Differences in extracellular matrix proteins between Friesian horses with aortic rupture, unaffected Friesians and Warmblood horses. Equine veterinary journal. Supplement This article is protected by copyright. All rights reserved..
de Koning, D. B., Laurenssen, B. F A, Koopmanschap, R. E., van Grevenhof, E. M., van Weeren, P. R., Hazeleger, W. & Kemp, B. (01.06.2016). Effects of a high carbohydrate diet and arginine supplementation during the rearing period of gilts on osteochondrosis prevalence at slaughter. Livestock Science, 188, (pp. 91-102) (12 p.).
Malda, Jos, Boere, Janneke, van de Lest, Chris H A, van Weeren, P René & Wauben, Marca H M (2016). Extracellular vesicles - new tool for joint repair and regeneration. Nature reviews. Rheumatology, 12, (pp. 243-249).
de Grauw, J. C., Visser-Meijer, M. C., Lashley, F., Meeus, P. & van Weeren, P. R. (01.03.2016). Intra-articular treatment with triamcinolone compared with triamcinolone with hyaluronate - A randomised open-label multicentre clinical trial in 80 lame horses. Equine Veterinary Journal, 48 (2), (pp. 152-158) (7 p.).
van Weeren, Paul René & Back, Willem (03.08.2016). Musculoskeletal Disease in Aged Horses and Its Management. Veterinary Clinics of North America. Equine Practice, 32 (2), (pp. 229-47) (19 p.). Copyright © 2016 Elsevier Inc. All rights reserved..
Gorissen, B.M.C., Wolschrijn, C.F., Bergmann, W., Meijer, E., Uilenreef, J.J., van Rietbergen, Bert & van Weeren, P.R. (2016). Proceedings of the 31st Conference of the European Association of Veterinary Anatomists Vienna, Austria 27-30 July 2016 Abstracts. Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia, 45 (S1), (pp. 30-31).
Boere, Janneke, van de Lest, Chris H A, Libregts, Sten F W M, Arkesteijn, Ger J A, Geerts, Willie J C, Nolte-'t Hoen, Esther N M, Malda, Jos, van Weeren, P René & Wauben, Marca H M (2016). Synovial fluid pretreatment with hyaluronidase facilitates isolation of CD44+ extracellular vesicles. Journal of Extracellular Vesicles, 5 (1).
de Water, E Van, Oosterlinck, M, Dumoulin, M, Korthagen, N M, van Weeren, P R, van den Broek, J, Everts, H, Pille, F & van Doorn, D A (13.10.2016). The preventive effect of two nutraceuticals on experimentally induced acute synovitis. Equine veterinary journal. Supplement This article is protected by copyright. All rights reserved..
Vindas Bolaños, R A, Cokelaere, S M, Estrada McDermott, J M, Benders, K E M, Gbureck, U, Plomp, S G M, Weinans, H, Groll, J, van Weeren, P R & Malda, J (20.08.2016). The use of a cartilage decellularized matrix scaffold for the repair of osteochondral defects - the importance of long-term studies in a large animal model. Osteoarthritis and Cartilage, 25 (3), (pp. 413–420). Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved..
Gorissen, Ben M C, Wolschrijn, Claudia F, van Vilsteren, Anouk A M, van Rietbergen, Bert & van Weeren, P René (2016). Trabecular bone of precocials at birth; Are they prepared to run for the wolf(f)?. European Journal of Morphology, 277 (7), (pp. 948-956). © 2016 Wiley Periodicals, Inc..
Geburek, Florian, Mundle, Kathrin, Conrad, Sabine, Hellige, Maren, Walliser, Ulrich, van Schie, Hans T M, van Weeren, René, Skutella, Thomas & Stadler, Peter M (2016). Tracking of autologous adipose tissue-derived mesenchymal stromal cells with in vivo magnetic resonance imaging and histology after intralesional treatment of artificial equine tendon lesions - A pilot study. Stem Cell Research and Therapy, 7 (12 p.).
  Articles - 2015
Schuurman, W, Klein, T J, Dhert, Wouter J A, van Weeren, P R, Hutmacher, D W & Malda, J (2015). Cartilage regeneration using zonal chondrocyte subpopulations - a promising approach or an overcomplicated strategy?. Journal of Tissue Engineering and Regenerative Medicine, 9 (6), (pp. 669-678) (10 p.). Copyright © 2012 John Wiley & Sons, Ltd..
Visser, Jetze, Levett, Peter A., te Moller, Nikae C. R., Besems, Jeremy, Boere, Kristel W. M., van Rijen, Mattie H. P., de Grauw, Janny C., Dhert, Wouter J. A., van Weeren, P. Rene & Malda, Jos (01.04.2015). Crosslinkable Hydrogels Derived from Cartilage, Meniscus, and Tendon Tissue. Tissue Engineering - Part A., 21 (7-8), (pp. 1195-1206) (12 p.).
Visser, Jetze, Gawlitta, Debby, Benders, Kim E. M., Toma, Selynda M. H., Pouran, Behdad, van Weeren, P. Rene, Dhert, Wouter J. A. & Malda, Jos (2015). Endochondral bone formation in gelatin methacrylamide hydrogel with embedded cartilage-derived matrix particles. Biomaterials, 37, (pp. 174-182) (9 p.).
Hessel, L N, Bosch, G, van Weeren, P R & Ionita, J-C (2015). Equine autologous platelet concentrates - A comparative study between different available systems. Equine Veterinary Journal, 47 (3), (pp. 319-325) (7 p.).
Ploeg, M, Gröne, A, Saey, V, de Bruijn, C M, Back, W, van Weeren, P R, Scheideman, W, Picavet, T, Ducro, B J, Wijnberg, I & Delesalle, C (03.11.2015). Esophageal Dysfunction in Friesian Horses - Morphological Features. Veterinary Pathology © The Author(s) 2014..
van den Top, J G B, Harkema, L, Lange, C, Ensink, J M, van de Lest, C H A, Barneveld, A, van Weeren, P R, Gröne, A & Martens, A (2015). Expression of p53, Ki67, EcPV2- and EcPV3 DNA, and viral genes in relation to metastasis and outcome in equine penile and preputial squamous cell carcinoma. Equine veterinary journal. Supplement, 47 (2), (pp. 188–195).
Egenvall, Agneta, Eisersiö, Marie, Rhodin, Marie, van Weeren, P.R. & Roepstorff, Lars (2015). Rein tension during canter. Equine and Comparative Exercise Physiology, 11 (2), (pp. 107-117) (11 p.).
Egenvall, Agneta, Roepstorff, Lars, Eisersiö, Marie, Rhodin, Marie & van Weeren, René (2015). Stride-related rein tension patterns in walk and trot in the ridden horse. Acta Veterinaria Scandinavica, 57 (1) (10 p.).
Petit, Audrey, Redout, Everaldo M, van de Lest, Chris H, de Grauw, Janny C, Müller, Benno, Meyboom, Ronald, van Midwoud, Paul, Vermonden, Tina, Hennink, Wim E & van Weeren, René (2015). Sustained intra-articular release of celecoxib from in situ forming gels made of acetyl-capped PCLA-PEG-PCLA triblock copolymers in horses. Biomaterials, 53, (pp. 426-436) (11 p.). Copyright © 2015 Elsevier Ltd. All rights reserved..
Jenner, F, van Osch, G J V M, Weninger, W, Geyer, S, Stout, T, van Weeren, René, Brama, P & van Weeren, René (2015). The embryogenesis of the equine femorotibial joint - The equine interzone. Equine Veterinary Journal, 47 (5), (pp. 620-622) (3 p.).
Ploeg, M, Saey, V, Delesalle, C, Gröne, A, Ducatelle, R, de Bruijn, M, Back, W, van Weeren, P R, van Loon, G & Chiers, K (2015). Thoracic Aortic Rupture and Aortopulmonary Fistulation in the Friesian Horse - Histomorphologic Characterization. Veterinary Pathology, 52 (1), (pp. 152-159).
  Articles - 2014
Smith, R, McIlwraith, W, Schweitzer, R, Kadler, K, Cook, J, Caterson, B, Dakin, S, Heinegård, D, Screen, H, Stover, S, Crevier-Denoix, N, Clegg, P, Collins, M, Little, C, Frisbie, D, Kjaer, M, van Weeren, René, Werpy, N, Denoix, J-M, Carr, A, Goldberg, A, Bramlage, L, Smith, M & Nixon, A (2014). Advances in the understanding of tendinopathies - a report on the Second Havemeyer Workshop on equine tendon disease. Equine Veterinary Journal, 46 (1), (pp. 4-9) (6 p.).
Estrada, R J, van Weeren, P R, van de Lest, C H A, Boere, J, Reyes, M, Ionita, J C, Estrada, M & Lischer, C J (2014). Comparison of healing in forelimb and hindlimb surgically induced core lesions of the equine superficial digital flexor tendon. Veterinary and Comparative Orthopaedics and Traumatology, 27 (5), (pp. 358-65) (8 p.).
van Hamel, S E, Bergman, H J, Puchalski, S M, Groot, M.W. & van Weeren, P R (2014). Contrast-enhanced computed tomographic evaluation of the deep digital flexor tendon in the equine foot compared to macroscopic and histological findings in 23 limbs. Equine Veterinary Journal, 46 (3), (pp. 300-5) (6 p.).
Cadby, Jennifer A, Buehler, Evelyne, Godbout, Charles, van Weeren, P René & Snedeker, Jess G (2014). Differences between the cell populations from the peritenon and the tendon core with regard to their potential implication in tendon repair. PLoS One, 9 (3) (11 p.).
Jenner, Florien, IJpma, Arne, Cleary, Mairead, Heijsman, Daphne, Narcisi, Roberto, van der Spek, Peter J, Kremer, Andreas, van Weeren, René, Brama, Pieter & van Osch, Gerjo J V M (15.08.2014). Differential gene expression of the intermediate and outer interzone layers of developing articular cartilage in murine embryos. Stem Cells and Development, 23 (16), (pp. 1883-98) (16 p.).
Fessel, Gion, Cadby, Jennifer, Wunderli, Stefania, Snedeker, Jess G & van Weeren, René (2014). Dose- and time-dependent effects of genipin crosslinking on cell viability and tissue mechanics - toward clinical application for tendon repair. Acta Biomaterialia, 10 (5), (pp. 1897-906) (10 p.).
Conze, Philipp, van Schie, Hans Tm, Staszyk, Carsten, Conrad, Sabine, Skutella, Thomas, Hopster, Klaus, Rohn, Karl, Stadler, Peter, Geburek, Florian & van Weeren, René (2014). Effect of autologous adipose tissue-derived mesenchymal stem cells on neovascularization of artificial equine tendon lesions. Regenerative Medicine, 9 (6), (pp. 743-57) (15 p.).
Estrada, Roberto, van Weeren, René, van de Lest, Chris, Boere, Janneke, Nagaly, Reyes, Ionita, Jean-Claude, Estrada, Manuel & Lischer, Christoph (2014). Effects of autologous conditioned plasma® (ACP on the healing of surgically induced core lesions in equine superficial digital flexor tendon. Pferdeheilkunde, 30 (6), (pp. 633-642) (10 p.).
Munsters, Carolien C B M, van Iwaarden, Alexandra, van Weeren, René & Sloet van Oldruitenborgh-Oosterbaan, Marianne M (2014). Exercise testing in Warmblood sport horses under field conditions. Veterinary Journal, 202 (1), (pp. 11-19) (9 p.). Copyright © 2014 Elsevier Ltd. All rights reserved..
van den Top, J G B, Harkema, L, Ensink, J M, Barneveld, A, Martens, A, van de Lest, C H A, van Weeren, P R & Gröne, A (2014). Expression of cyclo-oxygenases-1 and -2, and microsomal prostaglandin E synthase-1 in penile and preputial papillomas and squamous cell carcinomas in the horse. Equine veterinary journal. Supplement, 46 (5), (pp. 618-624) (7 p.). © 2013 EVJ Ltd..
de Grauw, J C, van Loon, J P A M, van de Lest, C H A, Brunott, A & van Weeren, P R (2014). In vivo effects of phenylbutazone on inflammation and cartilage-derived biomarkers in equine joints with acute synovitis. Veterinary Journal, 201 (1), (pp. 51-56) (6 p.).
Jenner, F, Närväinen, J, de Ruijter-Villani, M, Stout, T A E, van Weeren, P R & Brama, P (2014). Magnetic resonance microscopy atlas of equine embryonic development. Equine Veterinary Journal, 46 (2), (pp. 210-215) (6 p.).
van Loon, Johannes P A M, Jonckheer-Sheehy, Valerie S M, Back, Willem, van Weeren, René, Hellebrekers, Ludo J & Back, Wim (2014). Monitoring equine visceral pain with a composite pain scale score and correlation with survival after emergency gastrointestinal surgery. Veterinary Journal, 200 (1), (pp. 109-115) (7 p.). Copyright © 2014 Elsevier Ltd. All rights reserved..
Benders, K.E.M., Boot, W., van Weeren, René, Gawlitta, D., Bergman, E., Saris, D.B.F., Dhert, Wouter & Malda, Jos (2014). Multipotent stromal cells outperform chondrocytes on cartilage-derived matrix scaffolds. Cartilage, 5 (4), (pp. 221-230) (10 p.).
Van Weeren, P. René, Back, Willem & Back, Wim (01.01.2014). Technological advances in equestrian sports - Are they beneficial for both performance and welfare?. Veterinary Journal, 199 (3), (pp. 313-314) (2 p.).
Higler, M H, Brommer, H, L'Ami, J J, de Grauw, J C, Nielen, M, van Weeren, P R, Laverty, S, Barneveld, A & Back, W (2014). The effects of three-month oral supplementation with a nutraceutical and exercise on the locomotor pattern of aged horses. Equine veterinary journal. Supplement, 46 (5), (pp. 611-617) (7 p.).
de Koning, D B, van Grevenhof, E M, Laurenssen, B F A, van Weeren, P R, Hazeleger, W & Kemp, B (2014). The influence of floor type before and after 10 weeks of age on osteochondrosis in growing gilts. Journal of Animal Science, 92 (8), (pp. 3338-47) (10 p.).
Lönnell, A C, Bröjer, J, Nostell, K, Hernlund, E, Roepstorff, L, Tranquille, C A, Murray, R C, Oomen, A, van Weeren, René, Bitschnau, C, Montavon, S, Weishaupt, M A & Egenvall, A (2014). Variation in training regimens in professional showjumping yards. Equine Veterinary Journal, 46 (2), (pp. 233–238) (6 p.). © 2013 EVJ Ltd..
  Articles - 2013
Munsters, Carolien C B M, van den Broek, Jan, Welling, Emile, van Weeren, René & Sloet van Oldruitenborgh - Oosterbaan, Marianne M (2013). A prospective study on a cohort of horses and ponies selected for participation in the European Eventing Championship - reasons for withdrawal and predictive value of fitness tests. BMC Veterinary Research, 9.
Munsters, C.C.B.M., van den Broek, J., van Weeren, P.R. & Sloet van Oldruitenborgh-Oosterbaan, M.M. (2013). A prospective study on fitness, workload and reasons for premature training ends and temporary training breaks in two groups of riding horses. Preventive Veterinary Medicine, 108, (pp. 199-208) (10 p.).
Denoix, J.M., Jeffcott, L.B., McIlwraith, C. W. & van Weeren, P.R. (2013). A review of terminology for equine Juvenile OsteoChondral Conditions (JOCC) based on anatomical and functional considerations. Veterinary Journal, 197, (pp. 29-35) (7 p.).
van Weeren, P.R. (2013). About Rollkur, or low, deep and round: Why Winston Churchill and Albert Einstein were right. Veterinary Journal, 196, (pp. 290-293) (4 p.).
Ploeg, M., Saey, V., de Bruijn, C.M., Grone, A., Chiers, K., van Loon, G., Ducatelle, R., van Weeren, P.R., Back, W. & Delesalle, C. (2013). Aortic rupture and aorto-pulmonary fistulation in the Friesian horse: Characterisation of the clinical and gross post mortem findings in 24 cases. Equine veterinary journal. Supplement, 45, (pp. 101-106) (6 p.).
te Moller, Nikae, Brommer, Harold, Liukkonen, Jukka, Viren, Tuomas, Timonen, Matti, Puhakka, Pia H., Jurvelin, Jukka S., van Weeren, René & Töyräs, Juha (2013). Arthroscopic optical coherence tomography provides detailed information on articular cartilage lesions in horses. Veterinary Journal, 197 (3), (pp. 589-595).
Te Moller, N.C.R., Brommer, H., Liukkonene, J., Viren, T., Timonen, M., Puhakka, P., Jurvelin, J.S., van Weeren, P.R. & Toyras, J. (2013). Arthroscopic optical coherence tomography provides detailed information on cartilage lesions in horses. Veterinary Journal, 197, (pp. 589-595) (7 p.).
Egenvall, A, Tranquille, C A, Lönnell, A C, Bitschnau, C, Oomen, A, Hernlund, E, Montavon, S, Franko, M A, Murray, R C, Weishaupt, M A, Weeren, van R, Roepstorff, L & van Weeren, René (01.11.2013). Days-lost to training and competition in relation to workload in 263 elite show-jumping horses in four European countries. Preventive Veterinary Medicine, 112 (3-4), (pp. 387-400) (14 p.). Copyright © 2013 Elsevier B.V. All rights reserved..
Munsters, C.C.B.M, van den Broek, J., van Weeren, P.R. & Sloet van Oldruitenborgh-Oosterbaan, M.M. (2013). Effect of transport, riot control, training and night patrols on the workload and stress of mounted police horses. Animal Behaviour, 143, (pp. 52-60) (9 p.).
Benders, K.E.M., van Weeren, P.R., Badylak, S.F., Saris, D.B.F., Dhert, W.J.A. & Malda, J. (2013). Extracellular matrix scaffolds for cartilage and bone regeneration. Trends in Biotechnology, 31 (3), (pp. 169-176) (8 p.).
Cadby, J.A., David, F., van de Lest, C.H.A., Bosch, G., van Weeren, R., Snedeker, J.G. & van Schie, H.T. (2013). Further Characterisation of an Experimental Model of Tendinopathy in the Horse. Equine veterinary journal. Supplement, 45 no 5 ((September)), (pp. 642-648) (7 p.).
Schuurman, Wouter, Levett, Peter A, Pot, Michiel W, van Weeren, Paul René, Dhert, Wouter J A, Hutmacher, Dietmar W, Melchels, Ferry P W, Klein, Travis J & Malda, Jos (2013). Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs. Macromolecular Bioscience, 13 (5), (pp. 551-561) (11 p.). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim..
Orr, N, Hill, E W, Gu, J, Govindarajan, P, Conroy, J, van Grevenhof, E M, Ducro, B J, van Arendonk, J A M, Knaap, J H, van Weeren, P R, Machugh, D E, Ennis, S & Brama, P A J (2013). Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10. Animal Genetics, 44 (4), (pp. 408-412) (5 p.). © 2012 The Authors, Animal Genetics © 2012 Stichting International Foundation for Animal Genetics..
van Weeren, P.R. (2013). New in EVJ: the technical note. Equine Veterinary Journal, 45, (pp. 527-528) (2 p.).
Malda, Jos, de Grauw, Janny C., Benders, Kim E. M., Kik, Marja J. L., van de Lest, Chris H. A., Creemers, Laura B., Dhert, Wouter J. A. & van Weeren, P. Rene (21.02.2013). Of Mice, Men and Elephants - The Relation between Articular Cartilage Thickness and Body Mass. PLoS One, 8 (2) (8 p.).
Malda, J., de Grauw, J.C., Benders, K.E.M., Kik, M.J.L., van de Lest, C.H.A., Creemers, L.B., Dhert, W.J.A. & van Weeren, P.R. (2013). Of mice, men and elephants: the relation between articular cartilage thickness and body mass. PLoS One, 8 (2), (pp. e57683) (1 p.).
van Weeren, P.R. & Jeffcott, L.B. (2013). Problems and pointers in ostechondrosis: 20 years on. Veterinary Journal, 197, (pp. 96-102) (7 p.).
van Weeren, P René & Jeffcott, Leo B (2013). Problems and pointers in osteochondrosis - Twenty years on. Veterinary Journal, 197 (1), (pp. 96-102) (7 p.). Copyright © 2013 Elsevier Ltd. All rights reserved..
Brommer, H., Smeenk, L.A. & van Weeren, P.R. (2013). Stamceltherapie bij het paard. Tijdschrift voor Diergeneeskunde, 138, (pp. 183) (1 p.).
Rautiainen, J., Lehto, L.J., Tiitu, V., Kiviranta, O., Pulkkinen, H., Brunott, A., van Weeren, P.R., Brommer, H., Brama, P.A.J., Ellermann, J., Kiviranta, I., Nieminen, M.T. & Nissi, M.J. (2013). SWIFT imaging of osteochondral repair in an equine model. Radiology, 269, (pp. 113-121) (9 p.).
de Koning, D.B., van Grevenhof, E.M., Laurenssen, B.F.A., van Weeren, P.R., Hazeleger, W. & Kemp, B. (2013). The influence of dietary restriction before and after 10 weeks of age on osteochondrosis in growing gilts. Journal of Animal Science, 91, (pp. 5167-5176) (10 p.).
Schuurman, W, Harimulyo, E B, Gawlitta, D, Woodfield, T B F, Dhert, W J A, van Weeren, P R & Malda, J (18.04.2013). Three-dimensional assembly of tissue-engineered cartilage constructs results in cartilaginous tissue formation without retainment of zonal characteristics. Journal of Tissue Engineering and Regenerative Medicine Copyright © 2013 John Wiley & Sons, Ltd..
van Loon, J P A M, de Grauw, J C, Brunott, A, Weerts, E A W S & van Weeren, P R (2013). Upregulation of articular synovial membrane μ-opioid-like receptors in an acute equine synovitis model. Veterinary Journal, 196 (1), (pp. 40-46) (7 p.). Copyright © 2012 Elsevier Ltd. All rights reserved..
Munsters, Carolien C B M, van den Broek, Jan, van Weeren, René & Sloet van Oldruitenborgh-Oosterbaan, Marianne M (2013). Young Friesian horses show familial aggregation in fitness response to a 7-week performance test. Veterinary Journal, 198 (1), (pp. 193-199) (7 p.). Copyright © 2013 Elsevier Ltd. All rights reserved..
  Articles - 2012
van Loon, J.P.A.M., Menke, E.S., l'Ami, J.J., Jonckheer-Sheehy, V.S.M., Back, W. & van Weeren, P.R. (2012). Analgesic and anti-hyperalgesic effects of epidural morphine in an equine LPS-induced acute synovitis model. Veterinary Journal, 193 (2), (pp. 464-470) (7 p.).
Fedorovich, Natalja E, Schuurman, Wouter, Wijnberg, Hans M, Prins, Henk-Jan, van Weeren, P René, Malda, Jos, Alblas, Jacqueline & Dhert, Wouter J A (2012). Biofabrication of osteochondral tissue equivalents by printing topologically defined, cell-laden hydrogel scaffolds. Tissue Engineering - Part C: Methods, 18 (1), (pp. 33-44) (12 p.).
Fedorovich, N.E., Schuurman, W., Wijnberg, H.M., Prins, H., van Weeren, P.R., Malda, J., Alblas, J. & Dhert, W.J.A. (2012). Biofabrication of osteochondral tissue equivalents by printing topologically defined, cell-laden hydrogel scaffolds. Tissue Engineering - Part C: Methods, 18 (1), (pp. 33-44) (12 p.).
Malda, J, Benders, K E M, Klein, T J, de Grauw, J C, Kik, M J L, Hutmacher, D W, Saris, D B F, van Weeren, P R & Dhert, W J A (2012). Comparative study of depth-dependent characteristics of equine and human osteochondral tissue from the medial and lateral femoral condyles. Osteoarthritis and Cartilage, 20 (10), (pp. 1147-1151) (5 p.).
Viren, T., Huang, Y.P., Saarakkala, S., Pulkkinen, H., Tiitu, V., Linjama, A., Kiviranta, I., Lammi, M., Brunott, A., Brommer, H., van Weeren, P.R., Brama, P.A.J., Zheng, Y, Jurvelin, J.S. & Töyras, J. (2012). Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage. Journal of Medical Engineering and Technology, 36 (3), (pp. 185-192) (7 p.).
Kulmala, K.A.M., Pulkkinen, H., Rieppo, L., Tiitu, V., Kiviranta, I., Brommer, H., van Weeren, P.R., Brama, P.A.J., mikkola, M.T., Korhonen, R.K., Jurvelin, J.S. & Töyräs, J. (2012). Contrast enhanced computed tomography in evaluation of spontaneous repair of equine cartilage. Cartilage, 3 (3), (pp. 235-244) (10 p.).
Roger, C.W., Bolwell, C.F., Tanner, J.C. & van Weeren, P.R. (2012). Early exercise in the horse. Journal of Veterinary Behavior: Clinical Applications and Research, 7, (pp. 375-379) (5 p.).
Sleutjens, J., Smiet, E., van Weeren, P.R., van der Kolk, J.H., Back, W. & Wijnberg, I.D. (2012). Effect of head and neck position on intrathoracic pressure and arterial blood gas values in Dutch Warmblood riding horses during moderate exercise. American Journal of Veterinary Research, 73 (4), (pp. 522-528) (7 p.).
van Weeren, P.R. (2012). Equine biomechanics: From an adjunct of art to a science in its own right. Equine Veterinary Journal, 44, (pp. 506-508) (3 p.).
David, F., Cadby, J.A., Bosch, G., Brama, P., van Weeren, P.R. & van Schie, H. (2012). Short-term cast mobilisation is effective in reducing lesion propagation in a surgical model of equine superficial digital flexor tendon injury. Equine Veterinary Journal, 44, (pp. 570-575) (6 p.).
Brommer, H., Schipper, P., Barneveld, A. & van Weeren, P.R. (2012). Systemic or intrasynovial medication as singular or as combination treatment in horses with (peri-)synovial pain. Veterinary Record, 171 (21).
van Weeren, P.R. (2012). Tendon injury: The switch from curative to preventive medicine. Veterinary Journal, 194, (pp. 274-275) (2 p.).
Firth, E.C., Rogers, C.W., van Weeren, P.R., Barneveld, A., McIlwraith, A., Kawcak, C.W., Goodship, A.E. & Smith, R.K.W. (2012). The effect of previous conditioning exercise on diaphyseal and metaphyseal bone to imposition and withdrawal of training in young Thoroughbred horses. Veterinary Journal, 192, (pp. 34-40) (7 p.).
van Grevenhof, E.M., Heuven, H.C.M., van Weeren, P.R. & Bijma, P. (2012). The relationship between growth and osteochondrosis in specific joints in pigs. Livestock Science, 143 (1), (pp. 85-90) (6 p.). Article history: Received 18 October 2010 Received in revised form 26 August 2011 Accepted 1 September 2011.
  Articles - 2011
de Grauw, J.C., van de Lest, C.H.A. & van Weeren, P.R. (2011). A targeted lipidomics approach to the study of eicosanoid release in synovial joints. Arthritis Research and Therapy, 13 ((4):R123), (pp. 1-30) (30 p.).
de Grauw, J.C., Donabédion, M., van de Lest, C.H.A., Perona, G., Robert, C., Lepage, O., Martin-Rosset, W. & van Weeren, P.R. (2011). Assessment of synovial fluid biomarkers in healthy foals and in foals with tarsocrural osteochondrosis. Veterinary Journal, dec 190 (3), (pp. 390-395) (6 p.).
Schuurman, W., Khristov, V., Pot, M.W., van Weeren, P.R., Dhert, W.J.A. & Malda, J. (2011). Bioprinting of hybrid tissue constructs with tailorable mechanical properties. Biofabrication, 3 (2), (pp. 021001) (1 p.).
Blikslager, A., Christley, R., Jeffcott, L.B.J., Silver, I.A. & van Weeren, P.R. (2011). Dr Peter Rossdale, OBE, Editor Equine Veterinary Journal (1980-2010). Equine Veterinary Journal, 43, (pp. 2) (1 p.).
Pescosolido, L., Schuurman, W., Malda, J., Matricardi, P., Alhaigue, F., Coviello, T., van Weeren, P.R., Dhert, W.J.A., Hennink, W.E. & Vermonden, T. (2011). Hyaluronic acid and dextran-based semi-IPN hydrogels as biomaterials for bioprinting. Biomacromolecules, 12 (5), (pp. 1831-1838) (8 p.).
Catt, C.J., Schuurman, W., Sengers, B.G., van Weeren, P.R., Dhert, W.J.A., Please, C.P. & Malda, J. (2011). Mathematical modelling of tissue formation in chondrocyte filter cultures. European Cells and Materials, 22, (pp. 377-392) (16 p.).
Firth, E.C., Rogers, C.W., van Weeren, P.R., Barneveld, A., McIlwraith, C., Kawcak, C.E., Goodship, A.E. & Smith, R.K.W. (2011). Mild exercise early in life produces changes in bone size and strength but not density in proximal phalangeal, third metacarpal and third carpal bones of foals. Veterinary Journal, 190, (pp. 383-389) (7 p.).
van den Top, J.G.B., Ensink, J.M., Barneveld, A. & van Weeren, P.R. (2011). Penile and preputial squamous cell carcinoma in the horse and proposal of a classification system. Equine Veterinary Education, 23, (pp. 636-648) (13 p.).
Bosch, G., Moleman, M., Barneveld, A., van Weeren, P.R. & van Schie, J.T.M. (2011). The effect of platelet-rich plasma on the neovascularization of surgically created equine superficial digital flexor tendon lesions. Scandinavian Journal of Medicine and Science in Sports, 21, (pp. 554-561) (8 p.).
van Grevenhof, E.M., Ott, S., Hazeleger, W., van Weeren, P.R., Bijma, P. & Kemp, B. (2011). The effects of floor system and feeding level on the joint-specific prevalence of osteochondrosis in fattening pigs. Livestock Science, 135, (pp. 53-61) (9 p.).
van Weeren, P.R. (2011). The potential role of training programmes in reducing injuries. Pferdeheilkunde, 27, (pp. 706-709) (4 p.).
  Articles - 2010
van Weeren, P.R. (2010). “It works, so it’s fine”: Beyond clinical efficacy in treating joint disease in the horse. Veterinary Journal, 183, (pp. 121-122) (2 p.).
Elgersma, A.E., Wijnberg, I.D., Sleutjens, J., van der Kolk, J.H., van Weeren, P.R. & Back, W. (2010). A pilot study on objective quantification and anatomical modelling of in vivo head and neck positions commonly applied in training and competition of sport horses. Equine veterinary journal. Supplement, 42, (pp. 436-443) (8 p.).
van Loon, J.P.A.M., Back, W., Hellebrekers, L.J. & van Weeren, P.R. (2010). Application of a composite pain scale to objectively monitor horses with somatic and visceral pain under hospital conditions. Equine veterinary journal. Supplement, 30 (11), (pp. 641-649) (9 p.).
van Weeren, P.R., McGowan, C. & Haussler, K.K. (2010). Development of a structural and functional understanding of the equine back. Equine Veterinary Journal, 38, (pp. 393-400) (8 p.).
Bosch, G., van Schie, J.T.M., Groot, M.W. de, Cadby, J.A., van de Lest, C.H.A., Barneveld, A. & van Weeren, P.R. (2010). Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: a placebo-controlled experimental study. Journal of Orthopaedic Research, 28, (pp. 211-217) (7 p.).
Sloet van Oldruitenborgh-Oosterbaan, M.M., Genzel, W. & van Weeren, P.R. (2010). Factors influencing the career of Dutch sport horses. Equine Veterinary Journal, 42 ((suppl 38)), (pp. 28-32) (5 p.).
Kobrina, Y.E., Isaksson, H., Sinisaari, M., Brama, P.A.J., van Weeren, P.R., Helminen, H., Jurvelin, J.S. & Saarakkala, S. (2010). Infrared spectroscopy can detect both qualitative and quantitative differences in equine subchondral bone during maturation. Journal of Biomedical Optics, 15 (6), (pp. 067003) (1 p.).
van Loon, J P A M, de Grauw, J C, van Dierendonck, M, L'ami, J J, Back, W & van Weeren, P R (2010). Intra-articular opioid analgesia is effective in reducing pain and inflammation in an equine LPS induced synovitis model. Equine veterinary journal. Supplement, 42 (5), (pp. 412-9) (8 p.).
van Loon, J.P.A.M., de Grauw, J.C., van Dierendonck, M.C., l' Ami, J.J., Back, W. & van Weeren, P.R. (2010). Intra-articular opioid analgesia is effective in reducing pain and inflammation in an equine LPS induced synovitis model. Equine veterinary journal. Supplement, 42 (5), (pp. 412-419) (8 p.).
Malda, J., ten Hoope, W., Schuurman, W., van Osch, G.J.V.M., van Weeren, P.R. & Dhert, W.J.A. (2010). Localization of the potential zonal marker clusterin in native cartilage and in tissue-engineered constructs. Tissue Engineering, 16 (3), (pp. 897-904) (8 p.). Tissue Engineering - Part A.
van Weeren, P.R. (2010). On surfaces and soreness. Veterinary Journal, 186, (pp. 129-130) (2 p.).
van Weeren, P.R. & de Grauw, J.C. (2010). Pain in osteoarthritis. Veterinary Clinics of North America. Equine Practice, 26, (pp. 619-642) (23 p.).
van den Top, J.G.B., Ensink, J.M., Grone, A., Klein, W.R., Barneveld, A. & van Weeren, P.R. (2010). Penile and preputial tumours in the horse: Literature review and proposal of a standardised approach. Equine veterinary journal. Supplement, 42 (8), (pp. 746-757) (12 p.).
Goff, L., van Weeren, P.R., Jeffcott, L.B., Condie, P. & McGowan, C. (2010). Quantification of equine sacral and iliac motion during gait: A comparison between motion capture with skin-mounted and bone-fixated sensors. Equine Veterinary Journal, 42 (S38), (pp. 468-474) (7 p.).
de Grauw, J.C., Heinola, T., van Weeren, P.R., Kiviranta, I. & Konttinen, Y.T. (2010). Rapid relaese of high mobility group box protein-1 (HMGB-1) in transient arthritis. Clinical and Experimental Rheumatology, 28 (2), (pp. 292-293) (2 p.).
de Grauw, J C, Heinola, T, van Weeren, René, Kiviranta, I & Konttinen, Y T (21.05.2010). Rapid release of high mobility group box protein-1 (HMGB-1) in transient arthritis. Clinical and Experimental Rheumatology, 28 (2), (pp. 292-3) (2 p.).
Souza, M.V., van Weeren, P.R., van Schie, J.T.M. & van de Lest, C.H.A. (2010). Regional differences in biochemical, biomechanical and histomorphological characteristics of the equine suspensory ligament. Equine veterinary journal. Supplement, 42 (7), (pp. 611-620) (10 p.).
de Cocq, P., Mooren, M., Dortmans, A., van Weeren, P.R., Timmerman, M., Muller, M. & van Leeuwen, J.L. (2010). Saddle forces and leg forces during lateral movements in dressage. Equine Veterinary Journal, 38, (pp. 644-649) (6 p.).
Bosch, G., Lameris, M.C., van den Belt, A.J.M., Barneveld, A. & van Weeren, P.R. (2010). The propagation of induced tendon lesions in the equine superficial digital flexor tendon: An ex vivo study. Equine veterinary journal. Supplement, 42 (5), (pp. 407-411) (5 p.).
van Weeren, P.R., Firth, E.C. & Brama, P.A.J. (2010). To move or to perish: the importance of exercise during musculoskeletal development in the horse. Pferdeheilkunde, 26 (4), (pp. 581-587) (7 p.).
Kearney, C.M., van Weeren, P.R., Cornelissen, B.P.M., den Boon, P. & Brama, P.A.J. (2010). Which anatomical region determines a positive flexion test of the distal aspect of a forelimb in a nonlame horse?. Equine Veterinary Journal, 42 (6), (pp. 547-551) (5 p.).
  Articles - 2009
Gomez-Alvarez, C.B., Rhodin, M., Byström, A., Back, W. & van Weeren, P.R. (2009). Back kinematics of healthy trotting horses during treadmill versus over ground locomotion. Equine veterinary journal. Supplement, 41 (3), (pp. 297-300) (4 p.).
Hyttinen, M.M., Holopainen, J., van Weeren, P.R., Firth, E.C., Helminen, H.J. & Brama, P.A.J. (2009). Changes in collagen fibril network organization and glycosaminoglycan distribution in equine articular cartilage during maturation and growth. Journal of Anatomy, 215, (pp. 584-591) (8 p.).
Loomans, J.B.A., van Weeren, P.R. & Barneveld, A. (2009). Equine veterinary practice in perspective. Pferdeheilkunde, 25 (1), (pp. 22-27) (6 p.).
Grevenhof, I., Schurink, A., Ducro, B.J., van Weeren, P.R., van Tartwijk, J.M.F.M. & van Arendonk, J.A.M. (2009). Genetic variables of various manifestations of osteochondrosis and their correlations between and within joints of dutch warmblood horses. Journal of Animal Science, 87, (pp. 1906-1912) (7 p.).
de Grauw, Janny, Brommer, Harold & van Weeren, René (2009). Gewrichtsaandoeningen, bewegen is leven. Paard en Sport, (pp. 2-5) (4 p.).
Den Hartog, S M, Back, W, Brommer, H & van Weeren, P R (01.01.2009). In vitro evaluation of metacarpophalangeal joint loading during simulated walk. Equine veterinary journal. Supplement, 41 (3), (pp. 214-7) (4 p.).
den Hartog, S.M., Back, W., Brommer, H. & van Weeren, P.R. (2009). In vitro evaluation of metacarpophalangeal joint loading during stimulated walk. Equine veterinary journal. Supplement, 41 (3), (pp. 214-217) (4 p.).
de Grauw, J C, van de Lest, C H A, Brama, P A J, Rambags, B P B & van Weeren, P R (2009). In vivo effects of meloxicam on inflammatory mediators, MMP activity and cartilage biomarkers in equine joints with acute synovitis. Equine veterinary journal. Supplement, 41 (7), (pp. 693-9) (7 p.).
de Grauw, J.C., van de Lest, C.H.A., Brama, P.A.J., Rambags, B.P.B. & van Weeren, P.R. (2009). In vivo effects of meloxicam on inflammatory mediators, mmp activity and cartilage biomarkers in equine joints with acute synovitis. Equine veterinary journal. Supplement, 41 (7), (pp. 693-699) (7 p.).
de Grauw, Janny C, van de Lest, Chris H A & van Weeren, Paul René (2009). Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult - a longitudinal experimental study. Arthritis Research and Therapy, 11 (2), (pp. R35).
de Grauw, J.C., van de Lest, C.H.A. & van Weeren, P.R. (2009). Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study. Arthritis Research and Therapy, 11, (pp. R35) (8 p.).
Brama, P.A.J., Holopainen, J., van Weeren, P.R., Firth, E.C., Helminen, H.J. & Hyttinen, M.M. (2009). Influence of excercise and joint topography on depth-related spatial distribution of proteoglycan and collagen content in immature equine articular cartilage. Equine Veterinary Journal, 41 (6), (pp. 557-563) (7 p.).
Brama, P.A.J., Firth, E.C., van Weeren, P.R., Tuukkanen, J., Holopainen, J., Helminen, H.J. & Hyttinen, M.M. (2009). Influence of intensity and changes of physical activity on bone mineral density of immature equine subchondral bone. Equine Veterinary Journal, 41 (6), (pp. 564-571) (13 p.).
Roepstorff, L., Egenvall, A., Rhodin, M., Byström, A., Johnston, C., van Weeren, P.R. & Weishaupt, M. (2009). Kinetics and kinematics of the horse comparing left and right rising trot. Equine Veterinary Journal, 41 (3), (pp. 292-296) (5 p.).
Weishaupt, M.A., Byström, A., von Peinen, K., Wiestner, T., Meyer, H., Waldern, N., Johnston, C., van Weeren, P.R. & Roepstorff, L. (2009). Kinetics and kinematics of the passage. Equine Veterinary Journal, 41, (pp. 263-267) (5 p.).
van Schie, J.T.M., Bakker, E.M., Cherdchutham, W., Jonker, M.A., van de Lest, C.H.A. & van Weeren, P.R. (2009). Monitoring of the repair process of surgically created partial lesions in equine superficial digital flexor rendons by means of computerized ultrasonography. American Journal of Veterinary Research, 70, (pp. 37-48) (12 p.).
van Grevenhof, E.M., Ducro, B.J., van Weeren, P.R., van Tartwijk, J.M.F.M., van den Belt, A.J.M. & Bijma, P. (2009). Prevalence of various radiographic manifestations of osteochondrosis and their correlations between and within joints in dutch warmblood horses. Equine veterinary journal. Supplement, 41 (1), (pp. 11-16) (6 p.).
Loomans, J.B.A., Waaijer, P.G., Maree, J.T.M., van Weeren, P.R. & Barneveld, A. (2009). Quality of equine veterinary care. Part 2: client satisfaction in equine top sports medicine in The Netherlands. Equine Veterinary Education, 21, (pp. 421-428) (8 p.).
von Peinen, K., Wiestner, T., Bogisch, S., Roepstorff, L., van Weeren, P.R. & Weishaupt, M.A. (2009). Relationship between the forces of acting on the horse's back and the movements of rider and horse while walking on a treadmill. Equine Veterinary Journal, 41 (3), (pp. 285-291) (7 p.).
Wennerstrand, J., Gomez-Alvarez, C.B., Meulenbelt, R., Johnston, C., van Weeren, P.R., Roethlisberger-Holm, K. & Drevemo, S. (2009). Spinal kinematics in horses with induced back pain. Veterinary and Comparative Orthopaedics and Traumatology, 22, (pp. 448-454) (7 p.).
Rhodin, M., Gomez-Alvarez, C.B., Byström, A., Johnston, C., van Weeren, P.R., Roepstorff, L. & Weishaupt, M.A. (2009). The effect of different head and neck positions on the caudal back and hindlimb kinematics in the elite dressage horse at trot. Equine Veterinary Journal, 41 (3), (pp. 274-279) (6 p.).
Bosch, G., de Mos, M., van Binsbergen, R., van Schie, H.T., van de Lest, C.H.A. & van Weeren, P.R. (2009). The effect of focused extracorporeal shock wave therapy on collagen matrix and gene expression in normal tendons and ligaments. Equine veterinary journal. Supplement, 41 (4), (pp. 335-341) (7 p.).
de Cocq, P., Prinsen, H., Springer, M.C.N., van Weeren, P.R., Schreuder, M., Muller, M. & van Leeuwen, J.L. (2009). The effect of rising and sitting trot on back movements and head-neck position of the horse. Equine Veterinary Journal, 41 (5), (pp. 423-427) (5 p.).
Koolmees, P.A., Loomans, J.B.A., Barneveld, A. & van Weeren, P.R. (2009). The emancipation of the equine veterinary practitioner in the netherlands. Pferdeheilkunde, 25 (1), (pp. 28-37) (10 p.).
Schuurman, W., Gawlitta, D., Klein, T.J., ten Hoope, W., van Rijen, M.H.P., Dhert, W.J.A., van Weeren, P.R. & Malda, J. (2009). Zonal chondrocyte subpopulations reacquire zone-specific characteristics during in vitro redifferentiation. American Journal of Sports Medicine, 37 (Suppl. 1), (pp. 97S-104S).
  Articles - 2008
Holopainen, J.T., Halmesmäki, E., Harjula, T., Tuukkanen, J., Brama, P.A.J., van Weeren, P.R., Helminen, H.J. & Hyttinen, M.M. (2008). Changes in subchondral bone mineral density and collagen matrix organization in growing horses. Bone, 43, (pp. 1108-1114) (7 p.).
Donabédian, M., van Weeren, P.R., Perona, G., Fleurance, G., Robert, C., Léger, S., Lepage, O. & Martin-Rosset, W. (2008). Early changes in biomarkers of skeletal metabolism and their association to the occurrence of osteochondrosis (OC) in the horse. Equine Veterinary Journal, 40, (pp. 253-259) (7 p.).
van Weeren, P.R., Firth, E.C., Brommer, H., Hyttinen, M.M., Helminen, H.J., Rogers, C. W., de Groot, J. & Brama, P.A.J. (2008). Early exercise advances the maturation of glycosaminoglycans and collagen in the extracellular matrix of articular cartilage in the horse. Equine veterinary journal. Supplement, 40 (2), (pp. 128-135) (8 p.).
Gomez-Alvarez, C.B., l' Ami, J.J., Moffat, D., Back, W. & van Weeren, P.R. (2008). Effect of chiropractic manipulations on the kinematics of back and limbs in horses with clinically diagnosed back problems. Equine veterinary journal. Supplement, 40 (2), (pp. 153-159) (7 p.).
Rogers, C. W., Firth, E.C., McIlwraith, C. W., Barneveld, A., Goodship, A.E., Kawcak, C.E., Smith, R.K.W. & van Weeren, P.R. (2008). Evaluation of a new strategy to modulate skeletal development in racehorses by imposing track-based exercise during growth: The effects on 2- and 3-year-old racing careers. Equine Veterinary Journal, 40 (2), (pp. 119-127) (9 p.).
Rogers, C. W., Firth, E.C., McIlwraith, C. W., Barneveld, A., Goodship, A.E., Kawcak, C.E., Smith, R.K.W. & van Weeren, P.R. (2008). Evaluation of a new strategy to modulate skeletal development in thoroughbred performance horses by imposing track-based exercise during growth. Equine Veterinary Journal, 40 (2), (pp. 111-118) (8 p.).
van Weeren, P.R., Elwyn, C. & Firth, E.C. (2008). Future tools for early diagnosis and monitoring of musculoskeletal Injury: Biomarkers and CT. Veterinary Clinics of North America. Equine Practice, 24, (pp. 153-175) (22 p.).
van Weeren, P.R. (2008). How long will equestrian traditionalism resist science?. Veterinary Journal, 175, (pp. 289-290) (2 p.).
Loomans, J.B.A., van Weeren-Bitterling, M.S., van Weeren, P.R. & Barneveld, A. (2008). Occupational disability and job satisfaction in the equine veterinary profession: how sustainable is this tough job in a changing world?. Equine Veterinary Education, 20 (11), (pp. 597-607) (11 p.).
Loomans, J.B.A., van Weeren, P.R., Vaarkamp, H., Stolk, P.W.Th. & Barneveld, A. (2008). Quality of equine veterinary care: Where can it go wrong? A conceptual framework for the quality of equine healthcare, based on court cases against equine practitioners in The Netherlands. Equine Veterinary Education, 20 (3), (pp. 159-165) (7 p.).
Gomez-Alvarez, C.B., Bobbert, M.F., Lamers, L., Johnston, C., Back, W. & van Weeren, P.R. (2008). The effect of induced hindlimb lameness on thoracolumbar kinematics during treadmill locomotion. Equine veterinary journal. Supplement, 40 (2), (pp. 147-152) (6 p.).
Moffat, P.A., Firth, E.C., Rogers, C. W., Smith, R.K.W., Barneveld, A., Goodship, A.E., Kawcak, C.E., McIlwraith, C. W. & van Weeren, P.R. (2008). The influence of exercise during growth on ultrasonographic parameters of the superficial digital flexor tendon of young thoroughbred horses. Equine Veterinary Journal, 40 (2), (pp. 136-140) (5 p.).
Loomans, J.B.A., Kranenburg, L.C., van Weeren, P.R. & Barneveld, A. (2008). The use of veterinary medicinal products in equine practice in the Netherlands: balancing between the law and good veterinary practice. Equine Veterinary Education, 20, (pp. 320-328) (9 p.).
  Articles - 2007
Loomans, J.B.A., Stolk, P.W.Th., van Weeren, P.R., Vaarkamp, H. & Barneveld, A. (2007). A survey of the workload and clinical skills in current equine practices in the Netherlands. Equine Veterinary Education, 19 (3), (pp. 162-168) (7 p.).
Firth, E.C., Rogers, C. W., van Weeren, P.R., Barneveld, A., Kawcak, C.E., McIlwraith, C. W., Goodship, A.E. & Smith, R.K.W. (2007). Changes in diaphyseal and epiphyseal bone parameters in Thoroughbred horses after withdrawal from training. Journal of Musculoskeletal Neuronal Interactions, 7, (pp. 74-76) (3 p.).
Loomans, J.B.A., van Weeren, P.R., Stolk, P.W.Th., Vaarkamp, H. & Barneveld, A. (2007). Does equine medicine pay off?. Equine Veterinary Education, 19, (pp. 273-280) (8 p.).
Loomans, J.B.A., van Weeren, P.R., Stolk, P.W.Th., Vaarkamp, H. & Barneveld, A. (2007). Does equine veterinary medicine pay off? A survey of revenue in current practices in the Netherlands. Equine Veterinary Education, 19, (pp. 273-280) (8 p.).
Bosch, G., Lin, Y.L., van Schie, J.T.M., van de Lest, C.H.A., Barneveld, A. & van Weeren, P.R. (2007). Effect of extracorporeal shock wave therapy on the biochemical composition and metabolic activity of tenocytes in normal tendinous structures in ponies. Equine veterinary journal. Supplement, 39 (3), (pp. 226-231) (6 p.).
van Weeren, P.R. (2007). La conformation et l'exercise du poulain déterminent-ils ses performances futures?. Pratique Veterinaire Equine, 39, (pp. 119-126) (8 p.).
Huitema, L.F.A., van Weeren, R., van Balkom, B.W.M., Visser, T., van de Lest, C.H.A., Barneveld, A., Helms, J.B. & Vaandrager, A.B. (2007). Soluble factors released by ATDC5 cells affect the formation of calcium phosphate crystals. Biochimica et Biophysica Acta - Proteins and Proteomics, 1774, (pp. 1108-1117) (10 p.).
Gomez-Alvarez, C.B., Wennerstrand, J., Bobbert, M.F., Lamers, L., Johnston, C., Back, W. & van Weeren, P.R. (2007). The effect of induced forelimb lameness on thoracolumbar kinematics during treadmill locomotion. Equine veterinary journal. Supplement, 39 (3), (pp. 197-201) (5 p.).
Bobbert, M.F., Gomez-Alvarez, C.B., van Weeren, P.R., Roepstorff, L. & Weishaupt, M.A. (2007). Validation of vertical ground reaction forces on individual limbs calculated from kinematics of horse locomotion. Journal of Experimental Biology, 210, (pp. 1885-1896) (12 p.).
  Articles - 2006
de Grauw, J C, van de Lest, C H A, van Weeren, René, Brommer, H & Brama, P A J (2006). Arthrogenic lameness of the fetlock - synovial fluid markers of inflammation and cartilage turnover in relation to clinical joint pain. Equine veterinary journal. Supplement, 38 (4), (pp. 305-11) (7 p.).
de Grauw, J.C., van de Lest, C.H.A., van Weeren, P.R., Brommer, H. & Brama, P.A.J. (2006). Arthrogenic lameness of the fetlock: synovial fluid markers of inflammation and cartilage turnover in relation to clinical joint pain. Equine veterinary journal. Supplement, 38 (4), (pp. 305-311) (8 p.).
Santamaria, S., Bobbert, M.F., Back, W., Barneveld, A. & van Weeren, P.R. (2006). Can early training of show jumpers bias outcome of selection events?. Livestock Science, 102, (pp. 163-170) (8 p.).
de Grauw, Janny C, Brama, Pieter A, Wiemer, Peter, Brommer, Harold, van de Lest, Chris H & van Weeren, P Rene (2006). Cartilage-derived biomarkers and lipid mediators of inflammation in horses with osteochondritis dissecans of the distal intermediate ridge of the tibia. American Journal of Veterinary Research, 67 (7), (pp. 1156-62) (7 p.).
van Heel, M.C.V., van Weeren, P.R. & Back, W. (2006). Compensation for changes in hoof conformation between shoeing sessions through the adaptation of angular kinematics of the distal segments of the limbs of horses. American Journal of Veterinary Research, 67 (7), (pp. 1199-1203) (5 p.).
Kroekenstoel, A M, van Heel, M C V, van Weeren, P R & Back, W (01.11.2006). Developmental aspects of distal limb conformation in the horse - the potential consequences of uneven feet in foals. Equine veterinary journal. Supplement, 38 (7), (pp. 652-6) (5 p.).
Kroekenstoel, A.M., van Heel, M.C.V., van Weeren, P.R. & Back, W. (2006). Developmental aspects of distal limb conformation in the horse: differences with mature horses and the potential consequences of uneven feet in foals. Equine veterinary journal. Supplement, 7 (38), (pp. 652-656) (5 p.).
Weishaupt, M.A., Wiestner, T., von Peinen, K., Waldern, N., Roepstorff, L., van Weeren, P.R., Meyer, H. & Johnston, C. (2006). Effect of head and neck position on vertical ground reaction forces and interlimb coordination in the dressage horse ridden at walk and trot on a treadmill. Equine Veterinary Journal, 36, (pp. 387-392) (6 p.).
Lin, Y.L., Moolenaar, H., van Weeren, P.R. & van de Lest, C.H.A. (2006). Effect of microcurrent electrical tissue stimulation on equine tenocytes in culture. American Journal of Veterinary Research, 67, (pp. 271-276) (6 p.).
van Weeren, P.R. & Crevier-Denoix, N. (2006). Equine conformation: clues to performance and soundness?. Equine Veterinary Journal, 38 (7), (pp. 591-596) (6 p.).
van Weeren, P.R. (2006). Etiology, Diagnosis, and Treatment of OC(D). Clinical Techniques in Equine Practice, 5 (4), (pp. 248-258) (11 p.).
van Weeren, P.R. (2006). Functional kinematics of the equine back. Pferdeheilkunde, 5, (pp. 602-608) (7 p.).
Moleman, M., van Heel, M.C.V., van Weeren, P.R. & Back, W. (2006). Hoof growth between two shoeing sessions leads to a substantial increase of the moment about the distal, but not the proximal, interphalangeal joint. Equine veterinary journal. Supplement, 38, (pp. 170-174) (5 p.).
Brommer, H., Laasanen, Mikko S., Brama, P.A.J., van Weeren, P.R., Helminen, H.J. & Jurvelin, J.S. (2006). In Situ and Ex Vivo Evaluation of an Arthroscopic Indentation Instrument to Estimate the Health Status of Articular Cartilage in the Equine Metacarpophalangeal Joint. Veterinary Surgery, 266, (pp. 259-266) (8 p.).
Lin, Y.L., Moolenaar, H., van Weeren, P.R. & van de Lest, C.H.A. (2006). Influence of electrode placement on effective field strength in the superficial digital flexor tendon of horses. American Journal of Veterinary Research, 67 (5), (pp. 845-849) (5 p.).
Huitema, L.F.A., van Weeren, P.R., Barneveld, A., van de Lest, C.H.A., Helms, J.B. & Vaandrager, A.B. (2006). Iron ions derived from the nitric oxide donor sodium nitroprusside inhibit mineralization. European Journal of Pharmacology, 542, (pp. 48-53) (6 p.).
van der Harst, M.R., Bull, S., Brama, P.A.J., Barneveld, A., van Weeren, P.R. & van de Lest, C.H.A. (2006). Nitrite and nitrotyrosine concentrations in articular cartilage, subchondral bone, and trabecular bone of normal juvenile, normal adult, and osteoarthritic adult equine metacarpophalangeal joints. Journal of Rheumatology, 33 (8), (pp. 1662-1667) (6 p.).
Kurvers, C.M.H., van Weeren, P.R., Rogers, C. W. & VanDierendonck, M.C. (2006). Quantification of spontaneous locomotion activity in foals kept in pastures under various management conditions. American Journal of Veterinary Research, 67 (7), (pp. 1212-1217) (6 p.).
de Cocq, P, van Weeren, P R & Back, W (01.09.2006). Saddle pressure measuring - validity, reliability and power to discriminate between different saddle-fits. Veterinary Journal, 172 (2), (pp. 265-73) (9 p.).
de Cocq, P., van Weeren, P.R. & Back, W. (2006). Saddle pressure measuring: Validity, reliability and power to discriminatie between different saddle-fits. Veterinary Journal, 172, (pp. 265-273) (9 p.).
van Heel, M.C.V., van Weeren, P.R. & Back, W. (2006). Shoeing sound Warmblood horses with a rolled toe optimises hoof-unrollment and lowers peak loading during breakover. Equine veterinary journal. Supplement, 38 (3), (pp. 258-262) (5 p.).
van Heel, M C V, van Weeren, P R & Back, W (01.01.2006). Shoeing sound warmblood horses with a rolled toe optimises hoof-unrollment and lowers peak loading during breakover. Equine veterinary journal. Supplement, 38 (3), (pp. 258-62) (5 p.).
Gomez-Alvarez, C.B., Rhodin, M., Bobbert, M.F., Meyer, H., Weishaupt, M.A., Johnston, C. & van Weeren, P.R. (2006). The effect of head and neck position on the thoracolumbar kinematics in the unridden horse. Equine Veterinary Journal, 36, (pp. 445-451) (7 p.).
Wilmink, J.M., van den Boom, R., van Weeren, P.R. & Barneveld, A. (2006). The modified Meek technique as a novel method for skin grafting in horses: evaluation of acceptance, wound contraction and closure in chronic wounds. Equine veterinary journal. Supplement, 38 (4), (pp. 324-329) (6 p.).
Huitema, L.F.A., Vaandrager, A.B., van Weeren, P.R., Barneveld, A., Helms, J.B. & van de Lest, C.H.A. (2006). The nitric oxide donor sodium nitroprusside inhibits mineralization in ATDC5 cells. Calcified Tissue International, 78 (3), (pp. 171-177) (7 p.).
van Heel, M.C.V., Kroekenstoel, A.M., VanDierendonck, M.C., van Weeren, P.R. & Back, W. (2006). Uneven feet in a foal may develop as a consequence of lateral grazing behaviour induced by conformational traits. Equine veterinary journal. Supplement, 38 (7), (pp. 646-651) (6 p.).
  Articles - 2005
Sardari, K., Kazemi, H., Mohri, M. & van Weeren, P.R. (2005). Analgesia Effects of Detomidine HCI When Administered Into the Distal Interphalangeal Joint in Horses With Experimental Solar Pain. Journal of Equine Veterinary Science, 25 (6), (pp. 262-265) (4 p.).
Faber, M.J., Schamhardt, H.C., van Weeren, P.R., Johnston, C., Roepstorff, L. & Barneveld, A. (2005). Basic three-dimensional kinematics of the vertebral column of horses walking on a treadmill. American Journal of Veterinary Research, 61, (pp. 399-406) (7 p.).
van der Harst, M.R., DeGroot, J., Kiers, G.H., Brama, P.A.J., van de Lest, C.H.A. & van Weeren, P.R. (2005). Biochemical analysis of the articular cartilage and subchondral and trabecular bone of the metacarpophalangeal joint of horses with early osteoarthritis. American Journal of Veterinary Research, 66, (pp. 1238-1246) (9 p.).
Bobbert, Maarten F, Santamaría, Susana, van Weeren, P René, Back, Wim & Barneveld, Albert (01.09.2005). Can jumping capacity of adult show jumping horses be predicted on the basis of submaximal free jumps at foal age? A longitudinal study. Veterinary Journal, 170 (2), (pp. 212-21) (10 p.).
Bobbert, M.F., Santamaria, S.E., van Weeren, P.R., Back, W. & Barneveld, A. (2005). Can jumping of adult show jumping horses be predicted on the basis of submaximal free jumps at the basis of submaximal free jumps at foal age? A longitudinal study. Veterinary Journal, 170, (pp. 212-221) (10 p.).
Van Heel, M C V, Moleman, M, Barneveld, A, Van Weeren, P R & Back, W (01.11.2005). Changes in location of centre of pressure and hoof-unrollment pattern in relation to an 8-week shoeing interval in the horse. Equine veterinary journal. Supplement, 37 (6), (pp. 536-40) (5 p.).
van Weeren, P.R. & Nixon, A.J. (2005). Closing in on the equine joint. Equine Veterinary Journal, 37, (pp. 493-494) (2 p.).
van Weeren, P.R. (2005). Editorial. Equine ergonomics: a new era?. Equine Veterinary Journal, 37, (pp. 4-6) (3 p.).
Santamaria, S.E., Bobbert, M.F., Back, W., Barneveld, A. & van Weeren, P.R. (2005). Effect of early training on the jumping technique of horses. American Journal of Veterinary Research, 66, (pp. 418-424) (7 p.).
Suwannachot, P., Joosten, B.J.L.J., Klarenbeek, A., Hofma, J., Enzerink, E., van Weeren, P.R. & Everts, M.E. (2005). Effects of training on potassium homeostasis during exercise and skeletal muscle Na+, K+- ATPase concentration in young adult and middle-aged Dutch Warmblood horses. American Journal of Veterinary Research, 66, (pp. 1252-1258) (7 p.).
van Weeren, P.R. (2005). Equine Osteochondrosis: a challenging enigma. Pferdeheilkunde, 4, (pp. 285-290) (6 p.).
Sardari, K., Nowrouzian, I., Movaseghi, Ar., Soroori, S. & van Weeren, P.R. (2005). Experimental study of healing effect of sodium hyaluronate in deep digital flexor tendon injury in horses. Journal of the Faculty of Veterinary Medicine of Tehran University, 55, (pp. 1-8) (8 p.).
Lin, Y.L., Brama, P.A.J., Kiers, G.H., van Weeren, P.R. & DeGroot, J. (2005). Extracellular Matrix Composition of the Equine Superficial Digital Flexor Tendon: Relationship with Age and Anatomical Site. Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine, 52, (pp. 333-338) (6 p.).
Brommer, H., Brama, P.A.J., Helminen, H.J., van Weeren, P.R. & Jurvelin, J.S. (2005). Functional adaptation of articular cartilage from birth to maturity under the influence of loading: a biomechanical analysis. Equine veterinary journal. Supplement, 37, (pp. 148-154) (7 p.).
Lin, Y.L., Brama, P.A.J., Kiers, G.H., DeGroot, J. & van Weeren, P.R. (2005). Functional adaptation through changes in regional biochemical charateristics during maturation of equine superficial digital flexor tendons. American Journal of Veterinary Research, 66, (pp. 1623-1629) (7 p.).
Brommer, H., Laasanen, Mikko S., Brama, P.A.J., van Weeren, P.R., Helminen, H.J. & Jurvelin, J.S. (2005). Functional consequences of cartilage degeneration in the equine metacarpophalangeal joint: quantitative assessment of cartilage stiffness. Equine veterinary journal. Supplement, 37 (5), (pp. 462-467) (6 p.).
Brommer, H., Laasanen, Mikko S., Brama, P.A.J., van Weeren, P.R., Barneveld, A., Helminen, H.J. & Jurvelin, J.S. (2005). Influence of age, site, and degenerative state on the speed of sound in equine articular cartilage. American Journal of Veterinary Research, 66 (7), (pp. 1175-1180) (6 p.).
van den Boom, R., van de Lest, C.H.A., Bull, S., Brama, P.A.J., van Weeren, P.R. & Barneveld, A. (2005). Influence of repeated arthrocentesis and exercise on synovial fluid concentrations of nitric oxide, prostaglandin E2 and glycosaminoglycans in healthy equine joints. Equine veterinary journal. Supplement, 37, (pp. 250-256) (7 p.).
van de Lest, C.H.A., van den Hoogen, B.M. & van Weeren, P.R. (2005). Loading-induced changes in synovial fluid affect cartilage metabolism. Biorheology, 37, (pp. 45-55) (11 p.).
van den Boom, R., van der Harst, M.R., Brommer, H., Brama, P.A.J., Barneveld, A., van Weeren, P.R. & DeGroot, J. (2005). Relationship between synovial fluid levels of glycosaminoglycans, hydroxyproline and general MMP activity and the presence and severity of articular cartilage change on the proximal articular surface of P1. Equine veterinary journal. Supplement, 37, (pp. 19-25) (7 p.).
Wilmink, J.M. & van Weeren, P.R. (2005). Second-intention repair in the horse and pony and management of exuberant granulation tissue. Veterinary Clinics of North America. Equine Practice, 21, (pp. 15-32) (19 p.).
van der Harst, M.R., van de Lest, C.H.A., DeGroot, J., Kiers, G.H., Brama, P.A.J. & van Weeren, P.R. (2005). Study of Cartilage and Bone layers of the bearing surface of the Equine Metacarpophalangeal joint relative to different timescales of Maturation. Equine veterinary journal. Supplement, 37, (pp. 200-206) (7 p.).
  Articles - 2004
Brommer, H., Rijkenhuizen, A.B.M., Brama, P.A.J., Barneveld, A. & van Weeren, P.R. (2004). Accuracy of diagnostic arthroscopy for the assessment of cartilage damage in the equine metacarpophalangeal joint. Equine veterinary journal. Supplement, 36, (pp. 331-335) (5 p.).
van der Harst, M.R., Brama, P.A.J., van de Lest, C.H.A., Kiers, G.H., DeGroot, J. & van Weeren, P.R. (2004). An integral biochemical analysis of the main constituents of articular cartilage, subchondral and trabecular bone. Osteoarthritis and Cartilage, 12, (pp. 752-761) (10 p.).
van den Boom, R., Brama, P.A.J., Kiers, G.H., de Groot, J. & van Weeren, P.R. (2004). Assessment of the effects of age and joint disease on hydroxyproline and glycosaminoglycan concentrations in synovial fluid from the metacarpophalangeal joint of horses. American Journal of Veterinary Research, 65, (pp. 296-302) (7 p.).
Brama, P.A.J., van den Boom, R., Kiers, G.H., van Weeren, P.R. & de Groot, J. (2004). Collagenase-1 (MMP-1) activity in equine synovial fluid: influence of age, joint pathology, exercise and repeated arthrocentesis. Equine veterinary journal. Supplement, 36, (pp. 34-40) (7 p.).
Brommer, H., Brama, P.A.J., Barneveld, A. & van Weeren, P.R. (2004). Differences in the topographical distribution of articular cartilage degeneration between equine metacarpo- and metatarsophalangeal joints. Equine veterinary journal. Supplement, 36, (pp. 506-510) (5 p.).
van Heel, M C V, Barneveld, A, van Weeren, P R & Back, W (01.12.2004). Dynamic pressure measurements for the detailed study of hoof balance - the effect of trimming. Equine veterinary journal. Supplement, 36 (8), (pp. 778-82) (5 p.).
van Heel, M.C.V., Barneveld, A., van Weeren, P.R. & Back, W. (2004). Dynamic pressure measurements for the detailed study of hoof balance: the effect of trimming. Equine veterinary journal. Supplement, 36, (pp. 778-782) (5 p.).
de Cocq, P, van Weeren, P R & Back, W (01.12.2004). Effects of girth, saddle and weight on movements of the horse. Equine veterinary journal. Supplement, 36 (8), (pp. 758-63) (6 p.).
van Weeren, P.R. & Brama, P.A.J. (2004). Entwicklungsbedingte orthopädische Erkrankungen: Ätiologie und mögliche Beeinflussung durch Ernährung und Bewegung. Praktische Tierarzt, 85, (pp. 184-187) (4 p.).
Buchner, H.H.F., Mullineaux, D.R. & van Weeren, P.R. (2004). Equine locomotion in 2004. Equine Veterinary Journal, 36, (pp. 646-647) (2 p.).
Santamaria, S.E., Bobbert, M.F., Back, W., Barneveld, A. & van Weeren, P.R. (2004). Evaluation of consistency of jumping technique in horses between the ages of 6 months and 4 years. American Journal of Veterinary Research, 65, (pp. 945-950) (6 p.).
D.V.M. Billinghurst, R.C., Brama, P.A.J., van Weeren, P.R., Knowlton, M.S. & McIlwraith, C. W. (2004). Evaluation of serum concentrations of biomarkers of skeletal metabolism and results of radiography as indicators of severity of osteochondrosis in foals. American Journal of Veterinary Research, 65, (pp. 143-150) (8 p.).
van de Lest, C.H.A., Brama, P.A.J., van El, B., DeGroot, J. & van Weeren, P.R. (2004). Extracellular matrix changes in early osteochondrotic defects in foals: a key role for collagen?. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1690, (pp. 54-62) (9 p.).
Landman, M.A.A.M., de Blaauw, J.A., van Weeren, P.R. & Hofland, L.J. (2004). Field study of the prevalence of lameness in horses with back problems. Veterinary Record, 155, (pp. 165-168) (4 p.).
van Weeren, P.R. (2004). Structure and biomechanical concept of the equine back. Pferdeheilkunde, 20, (pp. 341-348) (8 p.).
de Cocq, P., van Weeren, P.R. & Back, W. (2004). The effects of a girth, a saddle and weight on the movements of the horse. Equine veterinary journal. Supplement, 36, (pp. 758-763) (6 p.).
van den Boom, R., Brama, P.A.J., Kiers, G.H., de Groot, J., Barneveld, A. & van Weeren, P.R. (2004). The influence of repeated arthrocentesis and exercise on matrix metalloproteinase and tumour necrosis factor alpha activities in normal equine joints. Equine veterinary journal. Supplement, 36, (pp. 155-159) (5 p.).
Santamaria, S.E., Bobbert, M.E., Back, W., Barneveld, A. & van Weeren, P.R. (2004). Variation in free jumping technique within and among horses with little experience in show jumping. American Journal of Veterinary Research, 65, (pp. 938-944) (7 p.).
  Articles - 2003
Suwannachot, P., Verkleij, C.B., van Weeren, P.R. & Everts, M.E. (2003). Ca2+ ATPase in Dutch warmblood foals compared with Na+, K+ ATPase: intermuscular differences and the effect of exercise. Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine, 50, (pp. 385-390) (6 p.).
van Schie, J.T.M., Bakker, E.M., Jonker, M.A. & van Weeren, P.R. (2003). Computerized ultrasonographic tissue characterization of equine superficial digital flexor tendons by means of stability quantification of echo patterns in contiguous transverse ultrasonographic images. American Journal of Veterinary Research, 64, (pp. 366-375) (10 p.).
Wilmink, J.M., Blom-Veenman, J.N., van den Boom, R., Rutten, V.P.M.G., Niewold, T.A., Broekhuisen-Davies, J.M., Lees, P., Armstrong, S., van Weeren, P.R. & Barneveld, A. (2003). Differences in polymorphonucleocyte function and local inflammatory response between horses and ponies. Equine veterinary journal. Supplement, 35 (6), (pp. 561-569) (9 p.).
van Weeren, P.R. & Brama, P.A.J. (2003). Equine joint disease in the light of new developments in articular cartilage research. Pferdeheilkunde, 19, (pp. 336-344) (9 p.).
van Weeren, P.R., Knaap, J.H. & Firth, E.C. (2003). Influence of liver copper status of mare and new-born foal on the development of osteochondrotic lesions. Equine Veterinary Journal, 35, (pp. 67-71) (5 p.).
Faber, M.J., van Weeren, P.R., Schepers, M. & Barneveld, A. (2003). Long-term follow-up of manipulative treatment in a horse with back problems. Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine, 50, (pp. 241-245) (5 p.).
Brommer, H., van Weeren, P.R. & Brama, P.A.J. (2003). New approach for quantitative assessment of articular cartilage degeneration in horses with osteoarthritis. American Journal of Veterinary Research, 64, (pp. 83-87) (5 p.).
Brommer, H., van Weeren, P.R., Brama, P.A.J. & Barneveld, A. (2003). Quantification and age-related distribution of articular cartilage degeneration in the equine fetlock joint. Equine veterinary journal. Supplement, 35, (pp. 697-701) (5 p.).
D.V.M. Billinghurst, R.C., Brama, P.A.J., van Weeren, P.R. & Knowlton, M.S. (2003). Significant exercise-related changes in the serum levels of two biomarkers of collagen metabolism in young horses. Osteoarthritis and Cartilage, 11, (pp. 760-769) (10 p.).
van de Lest, C.H.A., Brama, P.A.J. & van Weeren, P.R. (2003). The influence of exercise on bone morphogenic enzyme activity of immature equine subchondral bone. Biorheology, 40, (pp. 377-382) (6 p.).
  Articles - 2002
Brama, P.A.J., TeKoppele, J.M., Bank, R.A., Barneveld, A. & van Weeren, P.R. (2002). Biochemical development of subchondral bone from birth until age eleven months and the influence of physical activity. Equine Veterinary Journal, 34 (7), (pp. 143-149) (7 p.).
Spoormakers, T.J.P., Klein, W.R. & van Weeren, P.R. (2002). De behandeling van equine sarcoïden met cisplatine in arichide-olie: een bruikbaar alternatief?. Tijdschrift voor Diergeneeskunde, 127, (pp. 350-354) (5 p.).
Brama, P.A.J., TeKoppele, J.M., Bank, R.A., Barneveld, A. & van Weeren, P.R. (2002). Development of biochemical heterogeneity of articular cartilage: influences of age and exercise. Equine Veterinary Journal, 34, (pp. 265-269) (5 p.).
Santamaría, S, Back, W, van Weeren, P R, Knaap, J & Barneveld, A (01.09.2002). Jumping characteristics of naïve foals - lead changes and description of temporal and linear parameters. Equine veterinary journal. Supplement (34), (pp. 302-7) (6 p.).
Santamaria, S.E., Back, W., van Weeren, P.R., Knaap, J.H. & Barneveld, A. (2002). Jumping characteristics of naïve foals: lead changes and description of temporal and linear parameters. Equine veterinary journal. Supplement, 34 Supplem, (pp. 302-307) (6 p.). supplement.
Back, W., Schamhardt, H.C., Barneveld, A. & van Weeren, P.R. (2002). Longitudinal development of kinematics in Shetland ponies and the influence of feeding and training regimes. Equine veterinary journal. Supplement, 34, (pp. 609-614) (6 p.).
Faber, M.J., Johnston, C., van Weeren, P.R. & Barneveld, A. (2002). Repeatability of back kinematics in horses during treadmill locomotion. Equine Veterinary Journal, 34, (pp. 235-241) (7 p.).
Wilmink, J.M., van Herten, J., van Weeren, P.R. & Barneveld, A. (2002). Retrospective study of primary intention healing and sequestrum formation in horses compared to ponies under climnical circumstances. Equine Veterinary Journal, 34, (pp. 270-273) (4 p.).
van Weeren, P.R. (2002). The clinical applicability of automated gait analysis systems. Equine Veterinary Journal, 34, (pp. 218-219) (2 p.).
van de Lest, C.H.A., Brama, P.A.J. & van Weeren, P.R. (2002). The influence of exercise on the composition of developing equine joints. Biorheology, 39, (pp. 183-191) (9 p.).
  Articles - 2001
Becker, C.K., Cherdchutham, W., Enzerink, E., Spek, E.R. & van Weeren, P.R. (2001). A novel technique of taking tendon biopsies in the horse. A study on wound healing and the effect of exercise in immature superficial digital flexor tendons. Veterinary and Comparative Orthopaedics and Traumatology, 14, (pp. 214-221) (8 p.).
Faber-Meinders, M.J., Johnston, C., Schamhardt, H.C., van Weeren, P.R., Roepstorff, L. & Barneveld, A. (2001). Basic three-dimensional kinematics of the vertebral column of horses trotting on a treadmill. American Journal of Veterinary Research, 62, (pp. 757-764) (8 p.).
Brama, P.A., Karssenberg, D., Barneveld, A. & van Weeren, P.R. (01.01.2001). Contact areas and pressure distribution on the proximal articular surface of the proximal phalanx under sagittal plane loading. Equine Veterinary Journal, 33 (1), (pp. 26-32) (7 p.).
Wilmink, J.M., Nederbragt, H. & van Weeren, P.R. (2001). Differences in wound contraction between horses and ponies: the vitro contraction capacity of fibroblasts. Equine Veterinary Journal, 33, (pp. 499-505) (7 p.). et al..
Cherdchutham, W., Meershoek, L.S., van Weeren, P.R. & Barneveld, A. (2001). Effects of exercise on biochemical properties of the superficial digital flexor tendon in foals. American Journal of Veterinary Research, 62, (pp. 1859-1864) (6 p.).
Cherdchutham, W., Becker, C.K., Spek, E.R., Voorhout, W.F. & van Weeren, P.R. (2001). Effects of exercise on the diameter of collagen fibrils in the central core and periphery of the superficial digital flexor tendon in foals. American Journal of Veterinary Research, 62, (pp. 1563-1570) (8 p.).
van Schie, J.T.M., Bakker, E.M., Jonker, A.M. & van Weeren, P.R. (2001). Efficacy of computerized discrimination between structure-related and non-structure-related echoes in ultrasonographic images for the quantitative evaluation of the structural integrity of superficial digital flexor tendons in horses. American Journal of Veterinary Research, 62, (pp. 1159-1166) (8 p.).
Faber, M.J., Schamhardt, H.C., van Weeren, P.R. & Barneveld, A. (2001). Methodology and validity of assessing kinematics of the thoracolumbar vertebral column in horses on the basis of skin-fixated markers. American Journal of Veterinary Research, 62, (pp. 301-306) (6 p.).
van Weeren, P.R. & Brama, P.A.J. (2001). Physiology and pathology of the equine joint. Pferdeheilkunde, 17, (pp. 307-318) (12 p.).
Suwannachot, P., Verkleij, C.B., Kocsis, S., van Weeren, P.R. & Everts, M.E. (2001). Specificity and reversibility of the training effects on the concentration of Na+, K+-ATPase in foal skeletal muscle. Equine Veterinary Journal, 33, (pp. 250-255) (6 p.).
Meijer, M.C., van Weeren, P.R. & Rijkenhuizen, A.B.M. (2001). Streptococcus equi in the fetlock of a mature horse. Equine Veterinary Education, 13, (pp. 72-74) (3 p.).
Brama, P.A., Barneveld, A., Karssenberg, D., Van Kampen, G.P. & van Weeren, P.R. (01.05.2001). The application of an indenter system to measure structural properties of articular cartilage in the horse. Suitability of the instrument and correlation with biochemical data. Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine, 48 (4), (pp. 213-221) (9 p.).
Dik, K.J., van den Belt, A.J.M., Enzerink, E. & van Weeren, P.R. (2001). The radiographic development of the distal and proximal double contours of the equine navicular bone on dorsoproximal-palmarodistal oblique (upright pedal) radiographs, from age 1 to 11 months. Equine veterinary journal. Supplement, 33, (pp. 70-74) (5 p.).
Faber, M.J., Johnston, C., Schamhardt, H.C., van Weeren, R., Roepstorff, L. & Barneveld, A. (2001). Three-dimensional kinematics of the equine spine during canter. Equine Veterinary Journal, 33, (pp. 145-149) (5 p.). Suppl..
Brama, P.A.J., Bank, R.A., TeKoppele, J.M. & van Weeren, P.R. (2001). Training affects the collagen framework of subchrondal bone in foals. Veterinary Journal, 162, (pp. 24-32) (9 p.).
Busschers, E. & van Weeren, P.R. (2001). Use of the flexion test of the distal forelimb in the sound horse: repeatability and effect of age, gender, weight, height and fetlock range of motion. Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine, 48, (pp. 413-427) (15 p.).
Meijer, M.C., Busschers, E. & van Weeren, P.R. (2001). Which joint is most important for the positive outcome of a flexion test of the distal forelimb of a sound horse?. Equine Veterinary Education, 13, (pp. 319-323) (5 p.).
  Articles - 2000
Faber, M.J., Schamhardt, H.C., van Weeren, R., Johnston, C., Roepstorff, L. & Barneveld, A. (2000). Basic three-dimensional kinematics of the vertebral column of horses walking on a tredmill. American Journal of Veterinary Research, 61, (pp. 399-406) (8 p.).
Meijer, M.C., van Weeren, P.R. & Rijkenhuizen, A.B.M. (2000). Clinical experiences with treating septic arthritis in the equine by repeated joint lavage: a series of 39 cases. Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine, 47, (pp. 351-365) (15 p.).
Enzerink, E., van Weeren, P.R. & van der Velden, M.A. (2000). Closure of the abdominal wall at the umbilicus and the development of umbilical hernias in a group of foals from birth through to 11 months of age. Veterinary Record, 147, (pp. 37-39) (3 p.).
Brama, P.A.J., TeKoppele, J.M., Bank, R.A., Barneveld, A. & van Weeren, P.R. (2000). Functional adaptation of articular cartilage: the formation of regional biochemical characteristics during the first year of life in the horse. Equine Veterinary Journal, 32, (pp. 217-221) (5 p.).
Brama, P.A.J., TeKoppele, J.M., Beekman, B., Van El, B., Barneveld, A. & van Weeren, P.R. (2000). Influence of development and joint pathology on stromelysin enzyme activity in equine synovial fluid. Annals of the Rheumatic Diseases, 59, (pp. 155-157) (3 p.).
Wilmink, J.M., Blom-Veenman, J.N., Rutten, V.P.M.G., Niewold, T.A., Lees, P., Armstrong, S., van Weeren, P.R. & Barneveld, A. (2000). Kinetics of the early local inflammatory response determine the difference in efficiency of woundhealing between horses and ponies. Immunobiology, 203, (pp. 162-163) (2 p.).
van de Lest, C.H.A., van den Hoogen, B.M. & van Weeren, P.R. (2000). Loading-incuced changes in synovial fluid affect cartilage metabolism. Biorheology, 37, (pp. 45-55) (11 p.).
van Weeren, P.R. (2000). Osteochondrosis into the new millennium. Dier en arts, 15, (pp. 321-324) (4 p.).
Wilmink, J.M., Stolk, P.W.T., van Weeren, P.R. & Barneveld, A. (2000). The effectiveness of the haemodialysate Solcoseryl on second-intention wound healing of deep wounds in horses and ponies. Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine, 47, (pp. 311-320) (10 p.).
Brama, P.A.J., TeKoppele, J.M., Bank, R.A., Barneveld, A., Firth, E.C. & van Weeren, P.R. (2000). The influence of strenuous exercise on collagen characteristics of articular cartilage in Thoroughbreds age 2 years. Equine Veterinary Journal, 32, (pp. 551-554) (4 p.).
Brama, P. A J, Tekoppele, J. M., Bank, R. A., Karssenberg, D., Barneveld, A. & Van Weeren, P. R. (01.01.2000). Topographical mapping of biochemical properties of articular cartilage in the equine fetlock joint. Equine Veterinary Journal, 32 (1), (pp. 19-26) (8 p.).
van Schie, J.T.M., Bakker, E.M., Jonker, A.M. & van Weeren, P.R. (2000). Ultrasonographic tissue charcterization of equine SDF tendons by means of gray level statistics: a critical evaluation. American Journal of Veterinary Research, 61, (pp. 210-219) (10 p.).
  Articles - 1999
Back, W, Schamhardt, H C, Van Weeren, P R & Barneveld, A (01.07.1999). A comparison between the trot of pony and horse foals to characterize equine locomotion at young age. Equine veterinary journal. Supplement (30), (pp. 240-4) (5 p.).
Faber, M.J., Schamhardt, H.C. & van Weeren, R. (1999). Determination of 3D spinal kinematics without defining a local vertebral coordinate system. Journal of Biomechanics, 32 (12), (pp. 1355-1358) (4 p.).
  Articles - 1997
Keg, P R, van Weeren, P R, Back, W & Barneveld, A (01.11.1997). Influence of the force applied and its period of application on the outcome of the flexion test of the distal forelimb of the horse. Veterinary Record, 141 (18), (pp. 463-6) (4 p.).
  Articles - 1993
Back, W, Barneveld, A, van Weeren, P R & van den Bogert, A J (01.01.1993). Kinematic gait analysis in equine carpal lameness. Acta Anatomica, 146 (2-3), (pp. 86-9) (4 p.).
van Weeren, P R, van den Bogert, A J, Back, W, Bruin, G & Barneveld, A (01.01.1993). Kinematics of the standardbred trotter measured at 6, 7, 8 and 9 m/s on a treadmill, before and after 5 months of prerace training. Acta Anatomica, 146 (2-3), (pp. 154-61) (8 p.).
Back, W, van den Bogert, A J, van Weeren, P R, Bruin, G & Barneveld, A (01.01.1993). Quantification of the locomotion of Dutch Warmblood foals. Acta Anatomica, 146 (2-3), (pp. 141-7) (7 p.).
  Books - 2016
McIlwraith, C. W., Frisbie, D.D., Kawcak, C.E. & van Weeren, P.R. (2016). Joint Disease in the Horse. (408 p.). St. Louis, Missouri: Elsevier.
  Book parts / chapters - 2016
van Weeren, P.R. & Brama, Pieter A.J. (2016). Effects of Loading/Exercise on Articular Tissues and Developmental Aspects of Joints. In C. Wayne McIlwraith, David D. Frisbie, Christopher E. Kawcak & P. René van Weeren (Eds.), Joint Disease in the Horse (pp. 105-118) (14 p.). St. Louis MO: Elsevier.
McIlwraith, C. Wayne, Frisbie, David D., Kawcak, Christopher E., Goodrich, Laurie R. & van Weeren, P.R. (2016). Equine Joint Disease: Present and Future Directions in Research. Joint Disease in the Horse (pp. 376-398) (23 p.). St. louis MO: Elsevier.
van Weeren, P.R. (2016). General Anatomy and Physiology of Joints. In C. Wayne McIlwraith, David D. Frisbie, Christopher E. Kawcak & P. René van Weeren (Eds.), Joint Disease in the Horse (pp. 1-24) (24 p.). St. Louis MO: Elsevier.
van Weeren, P.R. (2016). Osteochondritis Dissecans. In C. Wayne McIlwraith, David D. Frisbie, Christopher E. Kawcak & P. René van Weeren (Eds.), Joint Disease in the Horse (pp. 57-83) (27 p.). St. Louis MO: Elsevier.
van Weeren, P.R. (2016). Septic Arthritis. In C. Wayne McIlwraith, David D. Frisbie, Christopher E. Kawcak & P. René van Weeren (Eds.), Joint Disease in the Horse (pp. 91-104) (14 p.). St. Louis MO: Elsevier.
  Book parts / chapters - 2013
de Cocq, P. & van Weeren, P.R. (2013). Functional biomechanics: effects of the rider and tack. In D.R. Hodgson, K. McKeever & C. McGowan (Eds.), The Athletic Horse: Principles and Practices of Equine Sports Medicine. 2nd ed (pp. 293-298) (6 p.). St. Louis: Elsevier.
van Weeren, P.R. (2013). History. In W. Back & H.M. Clayton (Eds.), Equine Locomotion (pp. 1-30) (30 p.). Edinburgh: Saunders Elsevier.
van Weeren, P.R. (2013). Joint physiology: response to exercise and training (Chapter 11). In K.W. Hinchcliff, A.J. Kaneps & R.J. Geor (Eds.), Equine Sports Medicine and Surgery. 2nd ed (pp. 213-222) (10 p.). St. Louis: Elsevier Saunders.
van Weeren, P.R. (2013). Kinematics of the equine back and pelvis. In D.R. Hodgson, K. McKeever & C. McGowan (Eds.), The Athletic Horse: Principles and Practices of Equine Sports Medicine. 2nd ed (pp. 282-292) (11 p.). St. Louis: Elsevier.
Birch, H.K., Brama, P.A.J., Firth, E.C., Goodship, A.J., Lopez Rivero, L.L. & van Weeren, P.R. (2013). The response of musculosketal tissue to exercise. In W. Back & W. Clayton (Eds.), Equine Locomotion. 2nd ed. (pp. 267-304) (38 p.). Edinburgh: Saunders Elsevier.
van Weeren, P.R. (2013). Training show jumpers. In D.R. Hodgson, K. McKeever & C. McGowan (Eds.), The Athletic Horse: Principles and Practices of Equine Sports Medicine. 2nd ed (pp. 337-346) (10 p.). St. Louis: Elsevier.
  Book parts / chapters - 2009
van Weeren, P.R. (2009). Kinematics of the equine back. In Henson, F.M.D. (Eds.), Equine back pathology. Diagnosis and treatment. (pp. 39-59) (21 p.). Chichester: Wiley-Blackwell.
  Book parts / chapters - 2006
van Weeren, P.R. (2006). Osteochondrosis. In J.A. Stick J.A. Auer (Eds.), Equine Surgery 3rd ed. (pp. 1166-1177) (12 p.).
  Book parts / chapters - 2005
Barneveld, A. & van Weeren, P.R. (2005). Hereditary aspects of the locomotor system. In W. Dr. Back & H.M. Clayton (Eds.), Equine Locomotion (8 p.). London: Saunders.
van Weeren, P.R. (2005). Hoofdstuk 13 : Fysiotherapie. In J. Kirpensteijn & W.R. Klein (Eds.), Leren opereren (pp. 233-239) (7 p.). Roman House Publishers.
van Weeren, P.R. (2005). Manejo clinico de las heridas en caballos atléticos. In Jose Luis Prof Dr López Rivero (Eds.), Cojeras del caballo deportivo (pp. 99-107) (9 p.). Córdoba, Espana: Universidad de Córdoba, Servicio de Reprografia.
van Weeren, P.R. (2005). Origen biomecania y manejo veterinario de los problemas de dorso. In Jose Luis Prof Dr López Rivero (Eds.), Cojeras del caballo deportivo (pp. 57-66) (10 p.). Córdoba, Espana: Universidad de Córdoba, Servicio de Reprografia.
van Weeren, P.R. & Brama, P.A.J. (2005). Physiology of growth development. In V. Juliand & W. Martin-Rosset (Eds.), The growing horse: nutrition and prevention of growth disorders (pp. 51-60) (10 p.). Wageningen Academic Publishers.
van Weeren, P.R. (2005). Prevención de cojeras mediante el manejo y el entrenamiento del caballo. In Jose Luis Prof Dr López Rivero (Eds.), Cojeras del caballo deportivo (pp. 122-129) (8 p.). Córdoba, Espana: Universidad de Córdoba, Servicio de Reprografia Córdoba.
  Book parts / chapters - 2003
van Weeren, P.R. (2003). Struktur und Funktion des Pferderückens. In A. Lindner (Eds.), Aspekte der Rehabilitation van Pferden mit Rückenproblemen (pp. 11-27) (17 p.). Essen: Arbeitsgruppe Pferd.
  Book parts / chapters - 2001
van Weeren, P.R. & Sloet van Oldruitenborgh-Oosterbaan, M.M. (2001). The Utrecht Veterinary Faculty. In P.R. Rossdale & R.E. Green (Eds.), Guardians of the Horse II (pp. 210-219) (10 p.). Newmarket: Romney Publications.
  Book parts / chapters - 2000
van Weeren, P.R. (2000). History of locomotor research. In W. Back & H.M. Clayton (Eds.), Equine locomotion (pp. 1-36) (36 p.). London: Saunders.
van de Lest, C.H.A., van den Hoogen, B.M. & van Weeren, P.R. (2000). Loading induced changes in synovial fluid affect cartilage metabolism. In J.F. Stolz (Eds.), Mechanobiology: Cartilage and chondrocyte (pp. 45-55) (11 p.). Amsterdam, the Netherlands: IOS Press.
  Articles in volumes / proceedings - 2015
Brommer, H. & van Weeren, P.R. (27.03.2015). How to exercise the growing horse until the start of training. How to exercise the growing horse until the start of training? (pp. 54-62) (9 p.).
Visser, J., Melchers, F, Mancini, I.A.D., Brommer, H., Jeon, June E, Dalton, P., Dhert, W.J.A., Saris, D.B.F., Hutmacher, Dietmar W, van Weeren, P.R. & Malda, J. (2015). Reinforced gelatin hydrogels for cartilage repair: from in vitro testing to implantation in the equine knee joint. Reinforced gelatin hydrogels for cartilage repair: from in vitro testing to implantation in the equine knee joint
Visser, J., Melchels, F.P.W., Mancini, I.A.D., Brommer, H., Jeon, June E, Dalton, Paul D, Dhert, W.J.A., Saris, D.B.F., Hutmacher, Dietmar W, van Weeren, P.R. & Malda, J. (2015). Reinforced gelatin hydrogels for cartilage repair; from in vitro testing to implantation in the equine stifle join. Reinforced gelatin hydrogels for cartilage repair; from in vitro testing to implantation in the equine stifle join
  Articles in volumes / proceedings - 2014
te Moller, Nikae, Pitkanen, M, Liukkonen, J., Puhakka, P H, Brommer, Harold, Jurvelin, J.S., van Weeren, René & Toyras, J. (2014). Automatic ICRS scoring of cartilage lesions using arthroscopic OCT images. Proceedings Orthopaedic Research Society (pp. PS1-1129) (1 p.). New Orleans: Orthopaedic Research Society.
te Moller, Nikae, Pitkanen, M, Liukkonen, J., Puhakka, P H, Brommer, Harold, Jurvelin, J.S., van Weeren, René & Toyras, J. (2014). Automatic ICRS scoring of cartilage lesions using arthroscopic OCT images. Automatic ICRS scoring of cartilage lesions using arthroscopic OCT images (pp. 57-58) (2 p.). Utrecht: Universiteit Utrecht, Faculty of Veterinary Medicine.
van Weeren, René (2014). Biomechanics of the back. BEVA Congress Handbook of Presentations 2014 (pp. 50-51) (2 p.). British Equine Veterinary Association.
Puhakka, P H, te Moller, Nikae, Pitkanen, M, Liukkonen, J., Brommer, Harold, Viren, T., Saarakkala, S., Jurvelin, J.S., van Weeren, René & Toyras, J. (2014). Quantitative assessment of articular cartilage using optical coherence tomography. Quantitative assessment of articular cartilage using optical coherence tomography (pp. ML1.5).
  Articles in volumes / proceedings - 2011
Kulmala, K.A.M., Pulkkinen, H.J., Rieppo, L., Tiitu, V., Kiviranta, I., Brunott, A., Brommer, H., van Weeren, P.R., Brama, P.A.J., mikkola, M.T., Korhonen, R.K., Jurvelin, J.S. & Töyräs, J. (2011). Contrast enhanced computed tomography in evaluation of spontaneous cartilage repair. 5th Osteoarthritis Imaging Workshop Salzburg 2011
  Articles in volumes / proceedings - 2010
Elgersma, A.E., Wijnberg, I.D., Sleutjens, J., van der Kolk, J.H., van Weeren, P.R. & Back, W. (08.11.2010). A pilot study on objective quantification and anatomical modelling of in vivo head and neck positions commonly applied in training and competition of sport horses. ICEEP 2010 (pp. 436-443) (8 p.). Cape Town, South-Africa, ICEEP 2010.
l'Ami, J.J., Higler, M.H., Brommer, H., de Grauw, J.C. & van Weeren, P.R. (30.06.2010). Kinematic evaluation of the effect of a 3-month oral glucosamine/chondroitin supplement on the locomotor pattern of a veteran horse population. ECVS 2010 (pp. 79-80) (2 p.). ECVS 2010.
  Articles in volumes / proceedings - 2009
Wijnberg, I.D., Sleutjens, J., van der Kolk, J.H., Smiet, E., Elgersma, A., van Denderen, J., Tiggelman, S., van Dierendonck, M.C., van Weeren, P.R. & Back, W. (2009). Effects of head and neck position during exercise, a multidisciplinary research project. Horse in the picture (pp. 27-27) (1 p.). Utrecht, Horse in the picture, Utrecht University.
Cokelaere, S.M., Brommer, H. & van Weeren, P.R. (06.11.2009). Osteochondrale allografting als behandeling van kraakbeenletsels. Proceedings Paard in the picture Utrecht, Symposium Paard in the picture.
van Weeren, P.R. (2009). Osteochondrosis in the horse: current concepts of pathogenesis and mechanism of the disease. Proceeding VI: Congresso da ordem dos médicos veterinarios
van Weeren, P.R. (2009). The biomechanical concept of the equine back. Proceedings of the British Equine Veterinary Association (pp. 191-192) (2 p.).
Bosch, G., van Schie, J.T.M., Groot, M.W. de, Cadby, J.A., van de Lest, C.H.A. & van Weeren, P.R. (23.04.2009). The effect of platelet rich plasma on the repair of surgically induced SDFT lesions. Proceedings van de Voorjaarsdagen Voorjaarsdagen.
van Weeren, P.R. (2009). Training for gold: where practice and science meet. Proceedings of the British Equine Veterinary Association (pp. 206-207) (2 p.).
  Articles in volumes / proceedings - 2008
Gomez-Alvarez, C.B., Rhodin, M., Back, W. & van Weeren, P.R. (16.06.2008). Back kinematics of healthy horses trotting on a treadmill vs overground. Proceedings of 6th International Conference on Equine Locomotion (ICEL 6) (pp. 76-76) (1 p.). 6th International Conference on Equine Locomotion (ICEL 6).
  Articles in volumes / proceedings - 2007
van Weeren, P.R. (22.11.2007). Biomarkers in synovial fluid. VII Congreso Internacional de Medicina y Cirugia Equina. (pp. 51-60) (10 p.).
Brama, P.A.J., de Grauw, J.C., Brommer, H. & van Weeren, P.R. (28.06.2007). Cartilage degeneration in fetlock osteoarthritis - what have we learned?. In M. Schramme, H. Tremaine, J. Walmsley & J. Houlton (Eds.), 16th Annual Scientific Meeting European College of Veterinary Surgeons. (pp. 123-129) (7 p.). Dublin.
van Weeren, P.R. (22.11.2007). Efectos del tratamiento manual en el lomo. VII Congreso Internacional de Medicina y Cirugia Equina. (pp. 93-97) (5 p.).
van Weeren, P.R. (22.11.2007). Movimientos del dorso: datos básicos e influencia de dolor de espalda o cojeras. VII Congreso Internacional de Medicina y Cirugia Equina. (pp. 69-81) (13 p.).
van Weeren, P.R. & Bobbert, M.F. (01.08.2007). Quantification of ground reaction forces. American Association of Equine Practitioners Lameness Research Meeting & Panel. (pp. 7-11) (5 p.). USA.
Bosch, G., Lin, Y.L., van Schie, J.T.M., van de Lest, C.H.A., Barneveld, A. & van Weeren, P.R. (28.06.2007). The effect of extracorporeal shockwave therapy on non-injured equine tendon. In M. Schramme, H. Tremaine, J. Walmsley & J. Houlton (Eds.), 16th Annual Scientific Meeting European College of Veterinary Surgeons. (pp. 43-44) (2 p.). Dublin.
van Weeren, P.R., Gomez-Alvarez, C.B., Bobbert, M.F., Johnston, C. & Back, W. (28.06.2007). The effect of induced subtle lameness on kinematics of the equine thoracolumbar spine. In M. Schramme, H. Tremaine, J. Walmsley, J. Houlton & J. Tremaine (Eds.), 16th Annual Scientific Meeting European College of Veterinary Surgeons. (pp. 200-202) (3 p.).
van Weeren, P.R. (22.11.2007). The influence of early exercise on the development of articular cartilage. VII Congreso Internacional de Medicina y Cirugia Equina. (pp. 35-43) (9 p.). VII Congreso Internacional de Medicinay Equina..
van Weeren, P.R. (22.11.2007). The latest about osteochondrosis. VII Congreso Internacional de Medicina y Cirugia Equina. (pp. 23-29) (7 p.). VII Congreso Internacional de Medicinay Cirugia Equine.
van Weeren, P.R. (10.02.2007). What moves and how in the back? Functional anatomy. In A. Lindner (Eds.), Conferencia Internacional de Caballos de Deporte. (pp. 81-93) (13 p.). San José.
  Articles in volumes / proceedings - 2006
de Grauw, Janny, van de Lest, Chris, van Weeren, René, Brommer, Harold & Brama, P. (2006). Arthrogenic lameness of the fetlock: synovial fluid markers of inflammation and cartilage turnover in relation to clinical joint pain. Arthrogenic lameness of the fetlock: synovial fluid markers of inflammation and cartilage turnover in relation to clinical joint pain. (pp. 91) (1 p.). Proceedings Britisch Equine Veterinary Association.
  Articles in volumes / proceedings - 2005
van Weeren, P.R., Brama, P.A.J. & Barneveld, A. (2005). Exercise at young age may influence the final quality of the equine musculoskeletal system. Proc. Am. Assoc. Equine Pract. 46 (pp. 29-35) (7 p.).
Brommer, H., Laasanen, Mikko S., Brama, P.A.J., van Weeren, P.R. & Jurvelin, J.S. (07.07.2005). Functional consequences of cartilage degeneration in the equine metacarpophalangeal joint: quantitative assessment of cartilage stiffness. In M. Schramme, H. Tremaine, J. Walmsley, C. Bellenger & J. Houlton (Eds.), 14th Annual Scientific Meeting, European College Veterinary Surgeons (pp. 60-64) (5 p.). Frankrijk.
  Articles in volumes / proceedings - 2004
van der Harst, M.R., DeGroot, J., van de Lest, C.H.A., Brama, P.A.J. & van Weeren, P.R. (2004). Changes in articular cartilage and subchondral bone in relation to osteoarthritis in the horse. In M. Schramme, H. Termaine, J. Walmsley, C. Bellenger & J. Houlton (Eds.), Proceedings 13th Ann, Sci.Meet.Eur.Coll.Vet.Surg. (pp. 147-149) (3 p.).
van Weeren, P.R., Brama, P.A.J., DeGroot, J., Barneveld, A., Rogers, C. W. & Firth, E.C. (2004). Conditioning of articular cartilage through early exercise: the effect on post-translational modifications of collagen. Proceedings Am. Assoc. Equine Pract. Focus on Joints Meet. (pp. 234-242) (9 p.).
Brama, P.A.J., Barneveld, A. & van Weeren, P.R. (2004). Functional adaptation of equine articular cartilage. Proceedings Am. Assoc. Equine Pract. Focus on Joints Meet. (pp. 145-156) (12 p.).
van Weeren, P.R. (2004). Grundlagen der Gelenkentwicklung und -erkrankungen wachsender Pferde. Göttinger Pferdetage. Zucht und Haltung von Sportpferden (pp. 189-197) (9 p.). Göttinger Pferdetage.
van Weeren, P.R. (2004). Osteochondrosis: developmental disorder or disorderly development?. In M. Schramme, H. Termaine, J. Walmsley, C. Bellenger & J. Houlton (Eds.), Proceedings 13th Ann, Sci.Meet.Eur.Coll.Vet.Surg. (pp. 164-175) (12 p.).
van Weeren, P.R. & Brama, P.A.J. (2004). Physiology of growth and development. 2nd European Workshop on Equine Nutrition. The growing horse: nutrition and prevention of growth disorders (pp. 49-60) (12 p.).
van den Boom, R., van der Harst, M.R., Brama, P.A.J., DeGroot, J., Barneveld, A. & van Weeren, P.R. (2004). Relationship between synovial fluid markers, cartilage composition and the presence and severity of OA in the equine metacarpophalangeal joint. In M. Schramme, H. Termaine, J. Walmsley, C. Bellenger & J. Houlton (Eds.), Proceedings 13th Ann, Sci.Meet.Eur.Coll.Vet.Surg. (pp. 152-154) (3 p.).
  Articles in volumes / proceedings - 2003
van Weeren, P.R. (2003). Entwicklungsbedingte orthopädische Erkrankungen des Fohlens - Aetiologie und mögliche Beeinflussung durch Arnährung und Bewegung. Proceedings of the Bundesverb. Prakt. Tierärzte Kongr. (pp. 29-33) (5 p.).
van Weeren, P.R. (2003). Inflammation, granulation and growth factors in equine wound healing. In S. Langley-Hobbs, H. Tremaine & M. Schramme (Eds.), Proceedings of the 12th Annual Scientific Meet. Europ. Coll. Vet. Surgery (pp. 173-179) (7 p.).
Brommer, H., Brama, P.A.J. & van Weeren, P.R. (2003). The effectiveness of arthroscopic inspection as diagnostic tool for the assessment of cartilage lesions in the equine fetlock joint. In S. Langley-Hobbs, H. Tremaine & M. Schramme (Eds.), Proceedings of the 12th Annual Sci. Meeting Europ. College Veterinary Surgery (pp. 206-207) (2 p.).
van den Boom, R., Brama, P.A.J., Kiers, G.H., de Groot, J. & van Weeren, P.R. (2003). The influence of age and joint disease on hydrocyproline levels in the synovial fluid from the equine metacarpophalangeal joint. In S. Langley-Hobbs, H. Tremaine & M. Schramme (Eds.), Proceedings of the 12th Annual Sci. Meet. Europ. Coll. Vet. Surg. (pp. 102-103) (2 p.).
  Articles in volumes / proceedings - 2002
Brommer, H., Brama, P.A.J. & van Weeren, P.R. (2002). A new technique for the quantitative assessment of articular cartilage degeneration in equine osteoarthitis. In S. May & J.F. Houlton (Eds.), Proc. 11th Ann. Sci. Meet. Europ. Coll. Vet. Surg. (pp. 174-176) (3 p.).
van den Boom, R., Brama, P.A.J., de Groot, J. & van Weeren, P.R. (2002). Exercise and repeated atrhrocentesis affect the level of matrix metalloproteinase activity in equine synovial fluid. In S. May & J.F. Houlton (Eds.), Proc. 11th Ann. Sci. Meet. Europ. Coll. Vet. Surg. (pp. 180-182) (3 p.).
Brama, P.A.J. & van Weeren, P.R. (2002). Matrix metalloproteinases as synovial markers: MMP-1 and MMP-3 under scrutiny. In S. May & J.F. Houlton (Eds.), Proc. 11th Ann. Sci. Meet. Europ. Coll. Vet. Surg. (pp. 171-173) (3 p.).
  Articles in volumes / proceedings - 2001
van Weeren, P.R. (2001). Efectos del entrenamiento en el desarrollo óptimo de tendones y articulaciones. Conference Internationale de Caballos de Deporte. (6 p.). published on cd-rom.
van Weeren, P.R. (2001). OCD and musculoskeletal development in the foal. Proceedings of the 1st UK Farriery Convention. (pp. 82-84) (3 p.).
Wilmink, J.M., van Weeren, P.R. & Barneveld, A. (2001). Second-intention wound healing in horses. Proceedings of the British Equine Veterinary Association. (pp. 102-103) (2 p.).
Wilmink, J.M., van den Boom, R. & van Weeren, P.R. (2001). Skin grafting in horses. Proceedings of the Veterinary Wound Healing Association.
Brama, P.A.J. & van Weeren, P.R. (2001). The development of biochemical heterogeneity of articular cartilage from neonatal to adult and the influence of exercise. In S. May & J.F. Houlton (Eds.), Proceedings Annual Science Meeting European College Veterinary Surgery. (pp. 86-89) (4 p.). no 10.
van Weeren, P.R., Knaap, J.H. & Firth, E.C. (2001). The influence of copper status at birth on the development of osteochondrotic lesions in the horse. In S. May & J.F. Houlton (Eds.), Proceedings of the Annual Science Meeting of the European College of Veterinary Surgery. (pp. 196-198) (3 p.).
  Reports - 2000
Dik, K.J., Knaap, J.H. & van Weeren, P.R. (2000). The efficacy of different selection measurements to reduce the osteochondrosis prevalence in the KWPN population. (46 p.). Utrecht: UU VET Companion Animal Health.
  Awards - 0
P.R. van Weeren () Equine Veterinary Journal Award of Merit 2007
P.R. van Weeren () The TVJ Junior Scientist Prize
  Inaugural speech - 2011
van Weeren, P.R. (2011). Man and horse: brothers in arms. (18 p.). Utrecht: Universiteit Utrecht, Inaugurele rede Universiteit Utrecht op maandag 14 april 2008.
  Lectures - 2016
P.R. van Weeren (14.01.2016) Diplôme d’Ecole de cinésiologie, physiothérapie et réadaptation vétérinaire
  Lectures - 2015
P.R. van Weeren (28.08.2015) Business and Ethics of Racing
P.R. van Weeren (30.06.2015) Musculoskeletal Health in the 21st Century
  Lectures - 2014
P.R. van Weeren (29.11.2014) 2nd int. Conf. Saddle Research Trust
P.R. van Weeren (30.11.2014) 2nd Saddle Research Trust Int. Workshop
P.R. van Weeren (12.09.2014) 53rd Congr. Brit. Equine Vet. Assoc.
P.R. van Weeren (22.11.2014) Biomarkers in der Synovialflüssigkeit.
P.R. van Weeren (23.05.2014) Biomarkers in synovial fluid.
P.R. van Weeren (12.09.2014) Biomechanics of the equine back
P.R. van Weeren (23.11.2014) Fortschritte in der Behandlung von chronischem Schmerz in OA einschließlich intraartikuläre Therapie mittels lokaler kontrollierter Abgabe von Medikamenten.
P.R. van Weeren (23.05.2014) Joint Physiology and advances in regenerative medicine of cartilage.
P.R. van Weeren (24.05.2014) Management of chronic pain in equine osteoarthritis – advances in drugs and delivery routes.
P.R. van Weeren (22.11.2014) Mit Bioprintern fabrizierte Scaffolds für osteochondrale Defekte.
P.R. van Weeren (25.05.2014) Natural history of and recommendations for the management of osteochondrosis lesions.
P.R. van Weeren (11.11.2014) Osteochondrosis in the horse.
P.R. van Weeren (12.09.2014) Pathogenesis of OCD: how does this translate to management of the clinical case?
P.R. van Weeren (11.11.2014) Regenerative medicine of articular tissues in the horse.
P.R. van Weeren (24.05.2014) The effect of training on the equine osteoarticular structures.
  Lectures - 2012
P.R. van Weeren (01.06.2012) Biomaterial approaches to induce zonal cartilage organization
P.R. van Weeren (16.06.2012) Biomechanics of Performance.
P.R. van Weeren (16.06.2012) Biomechanics of Performance: how to select a champion show jumper from foal age and can we influence this by early training?
P.R. van Weeren (15.09.2012) Biomechanics of the pelvis.
P.R. van Weeren (05.09.2012) Combining Extracellular Cartilage Matrix and Mesenchymal Stem Cells for Cartilage Tissue Engineering
P.R. van Weeren (14.09.2012) Conditioning of articular cartilage through early exercise: a preventative measure?
P.R. van Weeren (24.07.2012) Effects of exercise on musculoskeletal tissue and use of this knowledge in training protocols.
P.R. van Weeren (16.06.2012) Facts, Figures & Fiction about Flexion.
P.R. van Weeren (16.06.2012) How does the equine back work and what are associated problems?
P.R. van Weeren (14.09.2012) Management of chronic pain in equine osteoarthritis – advances in drugs and delivery routes.
P.R. van Weeren (06.12.2012) Similar Effect of Interleukin-1ß on Cartilage Explant Cultures in Media Supplemented with Adult Serum, Adult Synovial Fluid or Immature Serum
P.R. van Weeren (19.01.2012) The added value of quantitative kinematics: Facts and fiction about hyperflexion.
P.R. van Weeren (26.06.2012) The history of locomotor research.
P.R. van Weeren (23.09.2012) The Little-Schramme model of tendinopathy and how to monitor its evolution.
  Lectures - 2011
P.R. van Weeren (13.05.2011) Etiología, patogénesis y concepto actual de la osteocondrosis equina
P.R. van Weeren (26.10.2011) Facts, figures & fiction about flexion
P.R. van Weeren (28.10.2011) Facts, figures & fiction about flexion
P.R. van Weeren (13.05.2011) Prevalencia y factores de riesgo de osteocondroisis en diferentes razas de caballos
P.R. van Weeren (24.06.2011) Regeneration der traumatisierten Sehne
P.R. van Weeren (25.06.2011) Regeneration des traumatisierten Gelenks
P.R. van Weeren (02.11.2011) The potential of (hybrid) scaffolds for the treatment of orthopaedic disease
P.R. van Weeren (23.01.2011) The potential role of training programmes in reducing injuries
  Lectures - 2010
P.R. van Weeren (05.10.2010) A zonal approach to articular cartilage repair
P.R. van Weeren (04.11.2010) Biomechanics of the equine back in relation to the use of the horse, especially dressage.
P.R. van Weeren (04.11.2010) Biomechanics of the equine back.
P.R. van Weeren (08.11.2010) Development of a structural and functional understanding of the equine back.
P.R. van Weeren (24.09.2010) OC and related abnormalities in sport horses: Diagnosis and clinical importance.
P.R. van Weeren (04.11.2010) The effect of early jump training on show jump ability
P.R. van Weeren (04.11.2010) The influence of early training on the young Thoroughbred
P.R. van Weeren (05.11.2010) The influence of exercise on the developing musculoskeletal system
P.R. van Weeren (09.02.2010) Training dressage horses in the 21st century: facts, no fiction.
  Lectures - 2009
P.R. van Weeren (08.10.2009) A bird's eye view of orthopaedic research in utrecht.
P.R. van Weeren (30.10.2009) Cell-based therapy without cells: the affect of plateled-rich plasma on the healing of artificially created tendon lesions in the horse.
P.R. van Weeren (03.10.2009) Ostecondrose em equinos
P.R. van Weeren (12.09.2009) The biomechanical concept of the equine back.
P.R. van Weeren (12.09.2009) Training for gold: where practice and science meet.
  Lectures - 0
P.R. van Weeren () Comparison of Depth-dependent Characteristics of Equine and Human Articular Cartilage from the Knee Joint
P.R. van Weeren () Mesenchymal Stem Cells and Extracellular Cartilage Matrix-derived Scaffolds for Cartilage Defect Repair
  Editorial activity - 0
P.R. van Weeren () American Journal of Veterinary Research
P.R. van Weeren () Associate editor for orthopaedics'/ gait analysis
P.R. van Weeren () Equine Veterinary Journal
P.R. van Weeren () Pferdeheilkunde
P.R. van Weeren () Pferdeheilkunde
P.R. van Weeren () Tijdschrift voor Diergeneeskunde
P.R. van Weeren () Veterinary Journal
P.R. van Weeren () Veterinary Surgery
  Contribution to the work of national or international committees and working groups - 0
P.R. van Weeren () Associate Editor
P.R. van Weeren () Associate Editor
P.R. van Weeren () co-promotor bij: De Cocq, P. (2012) The biomechanical interaction between horse and rider. Wageningen University, April 18th, 2012
P.R. van Weeren () Deputy Editor
P.R. van Weeren () Deputy Editor
P.R. van Weeren () Lid wetenschappelijke adviesraad
P.R. van Weeren () Lid wetenschappelijke adviesraad
P.R. van Weeren () Member Editorial Advisory Board
P.R. van Weeren () Member editorial consulant board
P.R. van Weeren () Member editorial review board
P.R. van Weeren () Member of the board of scientific reviewers
P.R. van Weeren () Member of the Editorial Board
P.R. van Weeren () Member of the Editorial Board
P.R. van Weeren () Member of the editorial review board
P.R. van Weeren () Member of the scientific board
P.R. van Weeren () Member of the scientific board
P.R. van Weeren () Wissenschaftlicher Beirat
P.R. van Weeren () Wissenschaftlicher Beirat
P.R. van Weeren () Wissenschaftlicher beirat
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Gegenereerd op 2017-11-20 07:07:45
Project:
P15-23 William Hunter Revisited: Activating intrinsic cartilage repair to restore joint homeostasis
01.03.2017 to 31.03.2022
General project description 

In his famous textbook “On the diseases of articulating surfaces” published in the year 1743, William Hunter wrote “If we consult the standard Chirurgical Writers from Hippocrates down to the present Age, we shall find, that an ulcerated Cartilage is universally allowed to be a very troublesome Disease; that it admits of a Cure with more Difficulty than carious Bone; and that, when destroyed, it is not recovered”. Up until now this sentence still dictates the vision of orthopedic surgeons how to deal with joint disorders like osteoarthritis and cartilage trauma.



Recent scientific developments have challenged the view of William Hunter. First, distraction of the joint for just 6 weeks is sufficient to stimulate complete regrowth of an eroded articular cartilage surface in animal models and human patients. Second, resident stem cell populations have been identified in joint tissue such as cartilage, the bone marrow compartment below the subchondral bone plate, the synovial membrane and freely floating in the synovial fluid. Evidence shows that these cells can migrate to cartilage defects and can be activated to induce a regenerative response. Indeed, most likely by exploiting the regenerative potential of these stem or progenitor cell populations, it was shown in preliminary experiments that focal cartilage defects can be repaired by a biomaterial approach only in orthotopic focal cartilage defect equine and rabbit models. In these animals, chondral defects were filled with an injectable in situ gelating hydrogel that activates locally resident stem or progenitor cells. Indeed in rabbits, after 10 weeks defects were completely repaired in a cell-free approach. In the equine model, histological examination demonstrated the ingrowth of cells in the hydrogel two weeks after the arthroscopically guided implantation of the hydrogel in the chondral defect. A substantial part of these cells showed typical chondrocyte features. Taken together multiple lines of evidence demonstrates that articular cartilage can repair itself once the proper microenvironment is offered which unleashes its regenerative potential.



These exciting new developments open up a complete new avenue for the treatment of focal cartilage defects and osteoarthritis. Primary osteoarthritis and secondary osteoarthritis as a consequence of cartilage trauma earlier in life are among the most prevalent diseases in the Western World for which no effective cure is available. This proposal aims at bringing together leading Dutch groups on osteoarthritis research, which are well known for their pioneering work on the potential of intrinsic cartilage repair, with Dutch SMEs active in developing innovative treatments for joint regeneration. The program is furthermore supported by the Dutch Arthritis Foundation.
Within this proposal we intend to develop multidisciplinary projects along two intrinsically related themes:



Theme 1 is focusing on studies to explore the cellular basis of intrinsic cartilage repair and the role of biomechanics: This could be either stem cell populations residing in the joint but might also be chondrocyte subpopulations or alternative cell sources. Once identified we will aim at two strategies that can exploit these cell populations: i) development of bioactive scaffolds that in a cell-free manner can induce regeneration of lost cartilage tissue by activating these resident stem or progenitor cell populations; ii) controlled release strategies that release bioactive components that activate the regenerative potential of these cells.



Theme 2 is focusing on studies to explore the molecular basis of joint homeostasis by assessing the composition of synovial fluid in opposing conditions (catabolic versus anabolic conditions). This may lead to new diagnostics but also to new drugs / biologicals that can restore joint homeostasis.



Both themes are intrinsically related. For example joint distraction changes the catabolic osteoarthritic milieu in the joint into an anabolic regenerative milieu. Likewise, cell attracting hydrogels that fill up cartilage defects induce a regenerative response while in control animals similar defects result in cartilage catabolism. These opposing experimental conditions thus provide excellent models to study the fundamentals of joint homeostasis that could lead to new biomarkers of disease as well as new therapeutic interventions.

Role Researcher Funding
NWO grant: Applied and Engineering Sciences
Project members UU
External project members:
  • dr. H.B.J. (Marcel) Karperien
  • Prof. dr. G.J. van Osch
  • Prof. dr. H. Weinans
  • Prof. dr. F. Lafeber
  • dr. P. van der Kraan
  • dr P. Emans
  • dr T. Welting
  • Dutch Arthritis Foundation
  • Hy2Care B.V.
  • InGell B.V.
  • Crystal Therapeutics B.V.
  • QVQ B.V.
  • Percuros B.V.

Gegenereerd op 2017-11-20 07:07:45
Additional functions and activities

Associate Editor Equine Veterinary Journal

Gegenereerd op 2017-11-20 07:07:45
Full name
prof. dr. P.R. van Weeren Contact details
Willem C. Schimmelgebouw

Yalelaan 112
Room -
3584 CM  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 1062
Phone number (department) +31 30 253 1111
Postal address
Yalelaan 112
3584 CM    UTRECHT
The Netherlands
Gegenereerd op 2017-11-20 07:07:45
Last updated 24.07.2014