Dr. P. (Paula) Perez Pardo

David de Wiedgebouw
Universiteitsweg 99
Kamer OPEN WERKP
3584 CG Utrecht

Dr. P. (Paula) Perez Pardo

Assistant Professor
Pharmacology
+31 30 253 7353
p.perezpardo@uu.nl

Highlighted publications

Perez-Pardo, P., Dodiya, H. B., Engen, P. A., Forsyth, C. B., Huschens, A. M., Shaikh, M., Voigt, R. M., Naqib, A., Green, S. J., Kordower, J. H., Shannon, K. M., Garssen, J., Kraneveld, A. D., & Keshavarzian, A. (2019). Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice. Gut, 68, 829-843. https://doi.org/10.1136/gutjnl-2018-316844
Perez-Pardo, P., Kliest, T., Dodiya, H. B., Broersen, L. M., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2017). The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies. European Journal of Pharmacology, 817, 86-95. https://doi.org/10.1016/j.ejphar.2017.05.042
Peralta-Marzal, L. N., Prince, N., Bajic, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez-Pardo, P. (2021). The impact of gut microbiota-derived metabolites in autism spectrum disorders. International Journal of Molecular Sciences, 22(18), 1-25. [10052]. https://doi.org/10.3390/ijms221810052

Publications

2022

Scholarly publications

Zheng, Y., Prince, N. Z., Peralta Marzal, L. N., Ahmed, S., Garssen, J., Perez Pardo, P., & Kraneveld, A. D. (2022). The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10. International Journal of Molecular Sciences, 23(19). https://doi.org/10.3390/ijms231911013

2021

Scholarly publications

Zheng, Y., Bek, M. K., Prince, N. Z., Peralta Marzal, L. N., Garssen, J., Perez Pardo, P., & Kraneveld, A. D. (2021). The Role of Bacterial-Derived Aromatic Amino Acids Metabolites Relevant in Autism Spectrum Disorders: A Comprehensive Review. Frontiers in Neuroscience, 15, 1-17. [738220]. https://doi.org/10.3389/fnins.2021.738220
Peralta-Marzal, L. N., Prince, N., Bajic, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez-Pardo, P. (2021). The impact of gut microbiota-derived metabolites in autism spectrum disorders. International Journal of Molecular Sciences, 22(18), 1-25. [10052]. https://doi.org/10.3390/ijms221810052
Lopez-Rincon, A., Roozendaal, D. S., Spierenburg, H. M., Holm, A. L., Metcalf, R., Perez-Pardo, P., Kraneveld, A. D., & Tonda, A. (2021). Modelling Asthma Patients’ Responsiveness to Treatment Using Feature Selection and Evolutionary Computation. In P. A. Castillo, & J. L. Jiménez Laredo (Eds.), Applications of Evolutionary Computation - 24th International Conference, EvoApplications 2021, Held as Part of EvoStar 2021, Proceedings (Vol. 12694, pp. 359-372). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 12694 LNCS). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-72699-7_23
Zheng, Y., Verhoeff, T. A., Pardo, P. P., Garssen, J., & Kraneveld, A. D. (2021). The Gut-Brain Axis in Autism Spectrum Disorder: A Focus on the Metalloproteases ADAM10 and ADAM17. International Journal of Molecular Sciences, 22(1), 1-27. [118]. https://doi.org/10.3390/ijms22010118
Perez-Pardo, P., Grobben, Y., Willemsen-Seegers, N., Hartog, M., Tutone, M., Muller, M., Adolfs, Y., Pasterkamp, R. J., Vu-Pham, D., van Doornmalen, A. M., van Cauter, F., de Wit, J., Gerard Sterrenburg, J., Uitdehaag, J. C. M., de Man, J., Buijsman, R. C., Zaman, G. J. R., & Kraneveld, A. D. (2021). Pharmacological validation of TDO as a target for Parkinson’s disease. FEBS Journal, 288(14), 4311-4331. https://doi.org/10.1111/febs.15721

2020

Scholarly publications

Troisi, J., Autio, R., Beopoulos, T., Bravaccio, C., Carraturo, F., Corrivetti, G., Cunningham, S., Devane, S., Fallin, D., Fetissov, S., Gea, M., Giorgi, A., Iris, F., Joshi, L., Kadzielski, S., Kraneveld, A., Kumar, H., Ladd-Acosta, C., Leader, G., ... Fasano, A. (2020). Genome, Environment, Microbiome and Metabolome in Autism (GEMMA) Study Design: Biomarkers Identification for Precision Treatment and Primary Prevention of Autism Spectrum Disorders by an Integrated Multi-Omics Systems Biology Approach. Brain Sciences, 10(10), [743]. https://doi.org/10.3390/brainsci10100743
Roussin, L., Prince, N., Perez-Pardo, P., Kraneveld, A. D., Rabot, S., & Naudon, L. (2020). Role of the gut microbiota in the pathophysiology of autism spectrum disorder: Clinical and preclinical evidence. Microorganisms, 8(9), [1369]. https://doi.org/10.3390/microorganisms8091369

2019

Scholarly publications

Bullich, C., Keshavarzian, A., Garssen, J., Kraneveld, A., & Perez-Pardo, P. (2019). Gut Vibes in Parkinson's Disease: The Microbiota-Gut-Brain Axis. Movement Disorders Clinical Practice, 6(8), 639-651. https://doi.org/10.1002/mdc3.12840
van Sadelhoff, J. H. J., Perez Pardo, P., Wu, J., Garssen, J., van Bergenhenegouwen, J., Hogenkamp, A., Hartog, A., & Kraneveld, A. D. (2019). The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids. Frontiers in Endocrinology, 10, 247. https://doi.org/10.3389/fendo.2019.00247
Perez-Pardo, P., Dodiya, H. B., Engen, P. A., Forsyth, C. B., Huschens, A. M., Shaikh, M., Voigt, R. M., Naqib, A., Green, S. J., Kordower, J. H., Shannon, K. M., Garssen, J., Kraneveld, A. D., & Keshavarzian, A. (2019). Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice. Gut, 68, 829-843. https://doi.org/10.1136/gutjnl-2018-316844

2018

Scholarly publications

Perez-Pardo, P., Broersen, L. M., Kliest, T., van Wijk, N., Attali, A., Garssen, J., & Kraneveld, A. D. (2018). Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson's Disease. Frontiers in Aging Neuroscience, 10, [237]. https://doi.org/10.3389/fnagi.2018.00237
Perez-Pardo, P., Dodiya, H. B., Engen, P. A., Naqib, A., Forsyth, C. B., Green, S. J., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2018). Gut bacterial composition in a mouse model of Parkinson's disease. Beneficial microbes, 9(5), 799-814. https://doi.org/10.3920/BM2017.0202
Perez-Pardo, P., Dodiya, H. B., Broersen, L. M., Douna, H., van Wijk, N., Lopes da Silva, S., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2018). Gut-brain and brain-gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet. Nutritional Neuroscience, 21(6), 391-402. https://doi.org/10.1080/1028415X.2017.1294555

2017

Scholarly publications

Perez-Pardo, P., Hartog, M., Garssen, J., & Kraneveld, A. D. (2017). Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson's Disease. Current Topics in Behavioral Neurosciences, 4(4), 361-368. https://doi.org/10.1007/s40473-017-0129-2
Rietdijk, C. D., Perez-Pardo, P., Garssen, J., van Wezel, R. J. A., & Kraneveld, A. D. (2017). Exploring Braak's Hypothesis of Parkinson's Disease. Frontiers in Neurology, 8, [37]. https://doi.org/10.3389/fneur.2017.00037
Perez-Pardo, P., de Jong, E. M., Broersen, L. M., van Wijk, N., Attali, A., Garssen, J., & Kraneveld, A. D. (2017). Promising effects of neurorestorative diets on motor, cognitive, and gastrointestinal dysfunction after symptom development in a mouse model of Parkinson's disease. Frontiers in Aging Neuroscience, 9, [57]. https://doi.org/10.3389/fnagi.2017.00057
Perez-Pardo, P., Kliest, T., Dodiya, H. B., Broersen, L. M., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2017). The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies. European Journal of Pharmacology, 817, 86-95. https://doi.org/10.1016/j.ejphar.2017.05.042
Perez Pardo, P. (2017). Targeting the Gut-Brain axis in Parkinson's disease. [Doctoral thesis 1 (Research UU / Graduation UU), Universiteit Utrecht]. Utrecht University.
https://dspace.library.uu.nl/bitstream/handle/1874/354242/Perez_Pardo.pdf?sequence=1

2015

Scholarly publications

Perez Pardo, P., De Jong, E. M., Broersen, L. M., Attali, A., Van Wijk, N., Garssen, J., Olivier, B., & Kraneveld, A. D. (2015). Dietary interventions with strong preventive and therapeutic effects on both motor and non-motor symptoms in a mouse model of parkinson's disease. Neuro-degenerative Diseases, 15, 1319. https://doi.org/10.1159/000381736

2014

Scholarly publications

Perez-Pardo, P., Douna, H., Wijnands, T., Da Silva, S. L., Forsyth, C. B., Dodiya, H. B., Garssen, J., Olivier, B., Keshavarzian, A., & Kraneveld, A. D. (2014). The role of toll-like receptor-4 in gut-brain cross talk in a murine model of parkinson's disease. Gastroenterology, 146(5), 59. https://doi.org/10.1016/S0016-5085(14)60206-7
Perez Pardo, P., Wijnands, T., Lopes Da Silva, S., Forsyth, C., Dodiya, H., Garssen, J., Keshavarzian, A., & Kraneveld, A. (2014). The role of toll like receptor-4 in gut-brain cross talk in a murine model of parkinson's disease. Basic & Clinical Pharmacology & Toxicology, 115, 156-157.