Highlighted publications
Perez-Pardo, P., Dodiya, H. B., Engen, P. A., Forsyth, C. B., Huschens, A. M., Shaikh, M., Voigt, R. M., Naqib, A., Green, S. J., Kordower, J. H., Shannon, K. M., Garssen, J., Kraneveld, A. D., & Keshavarzian, A. (2019). Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice. Gut, 68, 829-843. https://doi.org/10.1136/gutjnl-2018-316844
Perez-Pardo, P., Kliest, T., Dodiya, H. B., Broersen, L. M., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2017). The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies. European Journal of Pharmacology, 817, 86-95. https://doi.org/10.1016/j.ejphar.2017.05.042
Peralta-Marzal, L. N., Prince, N., Bajic, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez-Pardo, P. (2021). The impact of gut microbiota-derived metabolites in autism spectrum disorders. International Journal of Molecular Sciences, 22(18), 1-25. Article 10052. https://doi.org/10.3390/ijms221810052
Publications
2024
Scholarly publications
Elford, J. D., Becht, N., Garssen, J., Kraneveld, A. D., & Perez-Pardo, P. (2024). Buty and the beast: the complex role of butyrate in Parkinson’s disease. Frontiers in Pharmacology, 15, Article 1388401. https://doi.org/10.3389/fphar.2024.1388401
https://dspace.library.uu.nl/bitstream/handle/1874/438460/fphar-15-1388401.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/438460/fphar-15-1388401.pdf?sequence=1
Prince, N., Peralta Marzal, L. N., Markidi, A., Ahmed, S., Adolfs, Y., Pasterkamp, R. J., Kumar, H., Roeselers, G., Garssen, J., Kraneveld, A. D., & Perez-Pardo, P. (2024). Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder. Acta Pharmacologica Sinica, 45(8), 1591-1603. https://doi.org/10.1038/s41401-024-01268-x
Markidi, A., Elford, J. D., Berkers, C., Kraneveld, A. D., & Perez-Pardo, P. (2024). Gut Microbes in Parkinson's Disease. In The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota (2 ed., pp. 217-240) https://doi.org/10.1016/b978-0-323-99971-7.00002-3
Peralta-Marzal, L. N., Rojas-Velazquez, D., Rigters, D., Prince, N., Garssen, J., Kraneveld, A. D., Perez-Pardo, P., & Lopez-Rincon, A. (2024). A robust microbiome signature for autism spectrum disorder across different studies using machine learning. Scientific Reports, 14(1), Article 814. https://doi.org/10.1038/s41598-023-50601-7
https://dspace.library.uu.nl/bitstream/handle/1874/435328/s41598-023-50601-7.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/435328/s41598-023-50601-7.pdf?sequence=1
2023
Scholarly publications
Zheng, Y., Prince, N., Hattem, C. V., Garssen, J., Pardo, P. P., & Kraneveld, A. D. (2023). The interaction between intestinal bacterial metabolites and phosphatase and tensin homolog in autism spectrum disorder. Molecular and Cellular Neuroscience, 124(March 2023), Article 103805. https://doi.org/10.1016/j.mcn.2022.103805
https://dspace.library.uu.nl/bitstream/handle/1874/435527/1-s2.0-S1044743122001117-main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/435527/1-s2.0-S1044743122001117-main.pdf?sequence=1
Kidwai, S., Rojas-Velazquez, D., Kožinec, D., Vaišvilas, L., Perez-Pardo, P., & Lopez-Rincon, A. (2023). Using Machine Learning for Drug Discovery in IBD. Abstract from 18th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, Paris, France. https://hal.science/hal-04097613
Rojas-Velazquez, D., Kidwai, S., Cerezin, L., de Vries, L., Besermenji, K., Perez-Pardo, P., & Lopez-Rincon, A. (2023). Feature Selection Applied to Microbiome for Drug Discovery. Abstract from 18th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, Paris, France. https://hal.science/hal-04097608
Kidwai, S., Barbiero, P., Meijerman, I., Tonda, A., Perez-Pardo, P., Lio, P., van der Maitland-Zee, A. H., Oberski, D. L., Kraneveld, A. D., & Lopez-Rincon, A. (2023). A robust mRNA signature obtained via recursive ensemble feature selection predicts the responsiveness of omalizumab in moderate-to-severe asthma. Clinical and Translational Allergy, 13(11), 1-11. Article e12306. https://doi.org/10.1002/clt2.12306
https://dspace.library.uu.nl/bitstream/handle/1874/434887/Clinical_Translational_All_-_2023_-_Kidwai_-_A_robust_mRNA_signature_obtained_via_recursive_ensemble_feature_selection.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/434887/Clinical_Translational_All_-_2023_-_Kidwai_-_A_robust_mRNA_signature_obtained_via_recursive_ensemble_feature_selection.pdf?sequence=1
Cui, H., Elford, J. D., Alitalo, O., Perez-Pardo, P., Tampio, J., Huttunen, K. M., Kraneveld, A., Forsberg, M. M., Myöhänen, T. T., & Jalkanen, A. J. (2023). Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon. Neurobiology of Aging, 129, 62-71. https://doi.org/10.1016/j.neurobiolaging.2023.05.007
2022
Scholarly publications
Rojas-Velazquez, D., Kidwai, S., Perez-Pardo, P., Oberski, D., Garssen, J., Kraneveld, A. D., & Lopez-Rincon, A. (2022). Towards a reduced feature selection pipeline in 16s rRNA microbiome data using Machine Learning. In The 9th Beneficial Microbes Conference https://hal.science/hal-04097623
Zheng, Y., Prince, N. Z., Peralta Marzal, L. N., Ahmed, S., Garssen, J., Perez Pardo, P., & Kraneveld, A. D. (2022). The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10. International Journal of Molecular Sciences, 23(19), Article 11013. https://doi.org/10.3390/ijms231911013
2021
Scholarly publications
Zheng, Y., Bek, M. K., Prince, N. Z., Peralta Marzal, L. N., Garssen, J., Perez Pardo, P., & Kraneveld, A. D. (2021). The Role of Bacterial-Derived Aromatic Amino Acids Metabolites Relevant in Autism Spectrum Disorders: A Comprehensive Review. Frontiers in Neuroscience, 15, 1-17. Article 738220. https://doi.org/10.3389/fnins.2021.738220
Peralta-Marzal, L. N., Prince, N., Bajic, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez-Pardo, P. (2021). The impact of gut microbiota-derived metabolites in autism spectrum disorders. International Journal of Molecular Sciences, 22(18), 1-25. Article 10052. https://doi.org/10.3390/ijms221810052
Lopez-Rincon, A., Roozendaal, D. S., Spierenburg, H. M., Holm, A. L., Metcalf, R., Perez-Pardo, P., Kraneveld, A. D., & Tonda, A. (2021). Modelling Asthma Patients’ Responsiveness to Treatment Using Feature Selection and Evolutionary Computation. In P. A. Castillo, & J. L. Jiménez Laredo (Eds.), Applications of Evolutionary Computation - 24th International Conference, EvoApplications 2021, Held as Part of EvoStar 2021, Proceedings (Vol. 12694, pp. 359-372). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 12694 LNCS). Springer. https://doi.org/10.1007/978-3-030-72699-7_23
https://dspace.library.uu.nl/bitstream/handle/1874/414943/Lopez_Rincon2021_Chapter_ModellingAsthmaPatientsRespons.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/414943/Lopez_Rincon2021_Chapter_ModellingAsthmaPatientsRespons.pdf?sequence=1
Zheng, Y., Verhoeff, T. A., Pardo, P. P., Garssen, J., & Kraneveld, A. D. (2021). The Gut-Brain Axis in Autism Spectrum Disorder: A Focus on the Metalloproteases ADAM10 and ADAM17. International Journal of Molecular Sciences, 22(1), 1-27. Article 118. https://doi.org/10.3390/ijms22010118
Perez-Pardo, P., Grobben, Y., Willemsen-Seegers, N., Hartog, M., Tutone, M., Muller, M., Adolfs, Y., Pasterkamp, R. J., Vu-Pham, D., van Doornmalen, A. M., van Cauter, F., de Wit, J., Gerard Sterrenburg, J., Uitdehaag, J. C. M., de Man, J., Buijsman, R. C., Zaman, G. J. R., & Kraneveld, A. D. (2021). Pharmacological validation of TDO as a target for Parkinson’s disease. FEBS Journal, 288(14), 4311-4331. https://doi.org/10.1111/febs.15721
2020
Scholarly publications
Troisi, J., Autio, R., Beopoulos, T., Bravaccio, C., Carraturo, F., Corrivetti, G., Cunningham, S., Devane, S., Fallin, D., Fetissov, S., Gea, M., Giorgi, A., Iris, F., Joshi, L., Kadzielski, S., Kraneveld, A., Kumar, H., Ladd-Acosta, C., Leader, G., ... Fasano, A. (2020). Genome, Environment, Microbiome and Metabolome in Autism (GEMMA) Study Design: Biomarkers Identification for Precision Treatment and Primary Prevention of Autism Spectrum Disorders by an Integrated Multi-Omics Systems Biology Approach. Brain Sciences, 10(10), Article 743. https://doi.org/10.3390/brainsci10100743
Roussin, L., Prince, N., Perez-Pardo, P., Kraneveld, A. D., Rabot, S., & Naudon, L. (2020). Role of the gut microbiota in the pathophysiology of autism spectrum disorder: Clinical and preclinical evidence. Microorganisms, 8(9), Article 1369. https://doi.org/10.3390/microorganisms8091369
2019
Scholarly publications
Bullich, C., Keshavarzian, A., Garssen, J., Kraneveld, A., & Perez-Pardo, P. (2019). Gut Vibes in Parkinson's Disease: The Microbiota-Gut-Brain Axis. Movement Disorders Clinical Practice, 6(8), 639-651. https://doi.org/10.1002/mdc3.12840
van Sadelhoff, J. H. J., Perez Pardo, P., Wu, J., Garssen, J., van Bergenhenegouwen, J., Hogenkamp, A., Hartog, A., & Kraneveld, A. D. (2019). The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids. Frontiers in Endocrinology, 10, 247. https://doi.org/10.3389/fendo.2019.00247
Perez-Pardo, P., Dodiya, H. B., Engen, P. A., Forsyth, C. B., Huschens, A. M., Shaikh, M., Voigt, R. M., Naqib, A., Green, S. J., Kordower, J. H., Shannon, K. M., Garssen, J., Kraneveld, A. D., & Keshavarzian, A. (2019). Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice. Gut, 68, 829-843. https://doi.org/10.1136/gutjnl-2018-316844
2018
Scholarly publications
Perez-Pardo, P., Broersen, L. M., Kliest, T., van Wijk, N., Attali, A., Garssen, J., & Kraneveld, A. D. (2018). Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson's Disease. Frontiers in Aging Neuroscience, 10, Article 237. https://doi.org/10.3389/fnagi.2018.00237
Perez-Pardo, P., Dodiya, H. B., Engen, P. A., Naqib, A., Forsyth, C. B., Green, S. J., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2018). Gut bacterial composition in a mouse model of Parkinson's disease. Beneficial microbes, 9(5), 799-814. https://doi.org/10.3920/BM2017.0202
Perez-Pardo, P., Dodiya, H. B., Broersen, L. M., Douna, H., van Wijk, N., Lopes da Silva, S., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2018). Gut-brain and brain-gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet. Nutritional Neuroscience, 21(6), 391-402. https://doi.org/10.1080/1028415X.2017.1294555
2017
Scholarly publications
Perez-Pardo, P., Hartog, M., Garssen, J., & Kraneveld, A. D. (2017). Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson's Disease. Current Topics in Behavioral Neurosciences, 4(4), 361-368. https://doi.org/10.1007/s40473-017-0129-2
Rietdijk, C. D., Perez-Pardo, P., Garssen, J., van Wezel, R. J. A., & Kraneveld, A. D. (2017). Exploring Braak's Hypothesis of Parkinson's Disease. Frontiers in Neurology, 8, Article 37. https://doi.org/10.3389/fneur.2017.00037
Perez-Pardo, P., de Jong, E. M., Broersen, L. M., van Wijk, N., Attali, A., Garssen, J., & Kraneveld, A. D. (2017). Promising effects of neurorestorative diets on motor, cognitive, and gastrointestinal dysfunction after symptom development in a mouse model of Parkinson's disease. Frontiers in Aging Neuroscience, 9, Article 57. https://doi.org/10.3389/fnagi.2017.00057
Perez-Pardo, P., Kliest, T., Dodiya, H. B., Broersen, L. M., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2017). The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies. European Journal of Pharmacology, 817, 86-95. https://doi.org/10.1016/j.ejphar.2017.05.042
Perez Pardo, P. (2017). Targeting the Gut-Brain axis in Parkinson's disease. [Doctoral thesis 1 (Research UU / Graduation UU), Universiteit Utrecht]. Utrecht University.
https://dspace.library.uu.nl/bitstream/handle/1874/354242/Perez_Pardo.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/354242/Perez_Pardo.pdf?sequence=1
2015
Scholarly publications
Perez Pardo, P., De Jong, E. M., Broersen, L. M., Attali, A., Van Wijk, N., Garssen, J., Olivier, B., & Kraneveld, A. D. (2015). Dietary interventions with strong preventive and therapeutic effects on both motor and non-motor symptoms in a mouse model of parkinson's disease. Neuro-degenerative Diseases, 15, 1319. https://doi.org/10.1159/000381736
2014
Scholarly publications
Perez-Pardo, P., Douna, H., Wijnands, T., Da Silva, S. L., Forsyth, C. B., Dodiya, H. B., Garssen, J., Olivier, B., Keshavarzian, A., & Kraneveld, A. D. (2014). The role of toll-like receptor-4 in gut-brain cross talk in a murine model of parkinson's disease. Gastroenterology, 146(5), 59. https://doi.org/10.1016/S0016-5085(14)60206-7
Perez Pardo, P., Wijnands, T., Lopes Da Silva, S., Forsyth, C., Dodiya, H., Garssen, J., Keshavarzian, A., & Kraneveld, A. (2014). The role of toll like receptor-4 in gut-brain cross talk in a murine model of parkinson's disease. Basic & Clinical Pharmacology & Toxicology, 115, 156-157.