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2025

Scholarly publications

Qiu, B., Pompe, S., Xenaki, K. T., Di Maggio, A., Moreno, C. B., van Bergen En Henegouwen, P. M. P., Mastrobattista, E., Oliveira, S., & Caiazzo, M. (2025). Receptor-mediated transcytosis of nanobodies targeting the heparin-binding EGF-like growth factor in human blood-brain barrier models. Journal of controlled release : official journal of the Controlled Release Society, 383, Article 113852. Advance online publication. https://doi.org/10.1016/j.jconrel.2025.113852
https://research-portal.uu.nl/ws/files/264473434/1-s2.0-S0168365925004729-main.pdf

2024

Scholarly publications

Bagchi, A., Stayrook, S. E., Xenaki, K. T., Starbird, C. A., Doulkeridou, S., el Khoulati, R., Roovers, R. C., Schmitz, K. R., van Bergen en Henegouwen, P. M. P., & Ferguson, K. M. (2024). Structural insights into the role and targeting of EGFRvIII. Structure, 32(9), 1367-1380.e6. https://doi.org/10.1016/j.str.2024.05.018
https://research-portal.uu.nl/ws/files/243981747/PIIS0969212624001953.pdf

Muns, J. A., Schooten, E., van Dasselaar, R. D. J., Noordman, Y. E., Adamzek, K., Eibergen, A. C., Pronk, S. D., Cali, S., Sijbrandi, N. J., Merkul, E., Oliveira, S., van Bergen en Henegouwen, P. M. P., Takkenberg, R. B., Verheij, J., van de Graaf, S. F. J., Nijmeijer, B. A., & van Dongen, G. A. M. S. (2024). Preclinical targeting of liver fibrosis with a 89Zr-labeled Fibrobody® directed against platelet derived growth factor receptor-β. European Journal of Nuclear Medicine and Molecular Imaging, 51(12), 3545-3558. https://doi.org/10.1007/s00259-024-06785-9
https://research-portal.uu.nl/ws/files/241246642/s00259-024-06785-9.pdf

de Bruijn, H. S., Mashayekhi, V., Schreurs, T. J. L., van Driel, P. B. A. A., Strijkers, G. J., van Diest, P. J., Lowik, C. W. G. M., Seynhaeve, A. L. B., Ten Hagen, T. L. M., Prompers, J. J., van Bergen En Henegouwen, P. M. P., Robinson, D. J., & Oliveira, S. (2024). Erratum: Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging: Erratum. Theranostics, 14(3), 1099-1100. https://doi.org/10.7150/thno.93248
https://dspace.library.uu.nl/bitstream/handle/1874/437086/v14p1099.pdf?sequence=1

2022

Scholarly publications

Zeronian, M. R., Doulkeridou, S., Van bergen en henegouwen, P. M. P., & Janssen, B. J. C. (2022). Structural insights into the non-inhibitory mechanism of the anti-EGFR EgB4 nanobody. BMC Molecular and Cell Biology, 23(1), Article 12. https://doi.org/10.1186/s12860-022-00412-x
https://dspace.library.uu.nl/bitstream/handle/1874/425087/Structural_insights_into_the_non_inhibitory_mechanism_of_the_anti_EGFR_EgB4_nanobody.pdf?sequence=1

Su, R., Wu, Y., Doulkeridou, S., Qiu, X., Sørensen, T. J., Susumu, K., Medintz, I. L., Van bergen en henegouwen, P. M. P., & Hildebrandt, N. (2022). A Nanobody‐on‐Quantum Dot Displacement Assay for Rapid and Sensitive Quantification of the Epidermal Growth Factor Receptor (EGFR). Angewandte Chemie-International Edition, 61(33), Article e202207797. https://doi.org/10.1002/anie.202207797
https://dspace.library.uu.nl/bitstream/handle/1874/425086/Angew_Chem_Int_Ed_2022_Su_A_Nanobody_on_Quantum_Dot_Displacement_Assay_for_Rapid_and_Sensitive_Quantification_of_the.pdf?sequence=1

Stam, J. C., De maat, S., De jong, D., Arens, M., Van lint, F., Gharu, L., Van roosmalen, M. H., Roovers, R. C., Strokappe, N. M., Wagner, R., Kliche, A., De haard, H. J., Van bergen en henegouwen, P. M., Nijhuis, M., & Verrips, C. T. (2022). Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies. Scientific Reports, 12(1), Article 13413. https://doi.org/10.1038/s41598-022-15993-y
https://dspace.library.uu.nl/bitstream/handle/1874/425085/s41598_022_15993_y.pdf?sequence=1

De la O Becerra, K. I., Oosterheert, W., van den Bos, R. M., Xenaki, K. T., Lorent, J. H., Ruyken, M., Schouten, A., Rooijakkers, S. H. M., van Bergen en Henegouwen, P. M. P., & Gros, P. (2022). Multifaceted Activities of Seven Nanobodies against Complement C4b. Journal of Immunology, 208(9), 2207-2219. https://doi.org/10.4049/jimmunol.2100647
https://dspace.library.uu.nl/bitstream/handle/1874/423472/2207.full.pdf?sequence=1

Mashayekhi, V., Schooten, E., van Bergen En Henegouwen, P. M. P., Kijanka, M. M., & Oliveira, S. (2022). Nanobody-Targeted Photodynamic Therapy: Nanobody Production and Purification. In Photodynamic Therapy: Methods and Protocols (pp. 481-493). (Methods in Molecular Biology; Vol. 2451). Springer. https://doi.org/10.1007/978-1-0716-2099-1_21
https://dspace.library.uu.nl/bitstream/handle/1874/420488/Pages_from_10.1007_978_1_0716_2099_1.pdf?sequence=1

van Lith, S. A. M., Huizing, F. J., Franssen, G. M., Hoeben, B. A. W., Lok, J., Doulkeridou, S., Boerman, O. C., Gotthardt, M., van Bergen En Henegouwen, P. M. P., Bussink, J., & Heskamp, S. (2022). Novel VHH-Based Tracers with Variable Plasma Half-Lives for Imaging of CAIX-Expressing Hypoxic Tumor Cells. Molecular Pharmaceutics, 19(10), 3511-3520. https://doi.org/10.1021/acs.molpharmaceut.1c00841
https://dspace.library.uu.nl/bitstream/handle/1874/423208/acs.molpharmaceut.1c00841.pdf?sequence=1

2021

Scholarly publications

Lamtha, T., Tabtimmai, L., Bangphoomi, K., Kiriwan, D., Malik, A. A., Chaicumpa, W., van Bergen En Henegouwen, P. M. P., & Choowongkomon, K. (2021). Generation of a nanobody against HER2 tyrosine kinase using phage display library screening for HER2-positive breast cancer therapy development. Protein Engineering, Design and Selection, 34, 1-11. Article gzab030. https://doi.org/10.1093/protein/gzab030
https://dspace.library.uu.nl/bitstream/handle/1874/415853/gzab030.pdf?sequence=1

Compte, M., Harwood, S. L., Martínez-Torrecuadrada, J., Perez-Chacon, G., González-García, P., Tapia-Galisteo, A., Van Bergen en Henegouwen, P. M. P., Sánchez, A., Fabregat, I., Sanz, L., Zapata, J. M., & Alvarez-Vallina, L. (2021). Case Report: An EGFR-Targeted 4-1BB-agonistic Trimerbody Does Not Induce Hepatotoxicity in Transgenic Mice With Liver Expression of Human EGFR. Frontiers in Immunology, 11, Article 614363. https://doi.org/10.3389/fimmu.2020.614363
https://dspace.library.uu.nl/bitstream/handle/1874/413008/fimmu_11_614363.pdf?sequence=1

Beltrán Hernández, I., Grinwis, G. C. M., Di Maggio, A., Van Bergen En Henegouwen, P. M. P., Hennink, W. E., Teske, E., Hesselink, J. W., Van Nimwegen, S. A., Mol, J. A., & Oliveira, S. (2021). Nanobody-targeted photodynamic therapy for the treatment of feline oral carcinoma: A step towards translation to the veterinary clinic. Nanophotonics, 10(12), 3075-3087. https://doi.org/10.1515/nanoph-2021-0195
https://dspace.library.uu.nl/bitstream/handle/1874/412839/10.1515_nanoph_2021_0195.pdf?sequence=1

Pronk, S. D., Schooten, E., Heinen, J., Helfrich, E., Oliveira, S., & Henegouwen, P. M. P. V. B. E. (2021). Single Domain Antibodies as Carriers for Intracellular Drug Delivery: A Proof of Principle Study. Biomolecules, 11(7), 1-16. Article 927. https://doi.org/10.3390/biom11070927
https://dspace.library.uu.nl/bitstream/handle/1874/412539/biomolecules_11_00927_v2.pdf?sequence=1

Xenaki, K. T., Dorrestijn, B., Muns, J. A., Adamzek, K., Doulkeridou, S., Houthoff, H., Oliveira, S., & van Bergen En Henegouwen, P. M. (2021). Homogeneous tumor targeting with a single dose of HER2-targeted albumin-binding domain-fused nanobody-drug conjugates results in long-lasting tumor remission in mice. Theranostics, 11(11), 5525-5538. https://doi.org/10.7150/thno.57510
https://dspace.library.uu.nl/bitstream/handle/1874/411979/v11p5525.pdf?sequence=1

2020

Scholarly publications

Damman, R., Kendek, A., Van Bergen en Henegouwen, P., & Baldus, M. (2020). Allosteric Nanobodies Modulate EGFR Functioning by Tuning Receptor Dynamics. SSRN. https://doi.org/10.2139/ssrn.3661772

Neviani, V., van Deventer, S., Wörner, T. P., Xenaki, K. T., van de Waterbeemd, M., Rodenburg, R. N. P., Wortel, I. M. N., Kuiper, J. K., Huisman, S., Granneman, J., van Bergen En Henegouwen, P. M. P., Heck, A. J. R., van Spriel, A. B., & Gros, P. (2020). Site-specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9. The FEBS journal, 287(24), 5323-5344. https://doi.org/10.1111/febs.15295
https://dspace.library.uu.nl/bitstream/handle/1874/410313/febs.15295.pdf?sequence=1

Mashayekhi, V., Xenaki, K. T., van Bergen En Henegouwen, P. M. P., & Oliveira, S. (2020). Dual Targeting of Endothelial and Cancer Cells Potentiates In Vitro Nanobody-Targeted Photodynamic Therapy. Cancers, 12(10), Article 2732. https://doi.org/10.3390/cancers12102732
https://dspace.library.uu.nl/bitstream/handle/1874/409751/cancers_12_02732_v2.pdf?sequence=1

Damman, R., Lucini Paioni, A., Xenaki, K. T., Beltrán Hernández, I., van Bergen en Henegouwen, P. M. P., & Baldus, M. (2020). Development of in vitro-grown spheroids as a 3D tumor model system for solid-state NMR spectroscopy. Journal of Biomolecular NMR, 74(8-9), 401-412. https://doi.org/10.1007/s10858-020-00328-8
https://dspace.library.uu.nl/bitstream/handle/1874/409600/Damman2020_Article_DevelopmentOfInVitro_grownSphe.pdf?sequence=1

Oosterheert, W., Xenaki, K. T., Neviani, V., Pos, W., Doulkeridou, S., Manshande, J., Pearce, N. M., Kroon-batenburg, L. M., Lutz, M., Van Bergen En Henegouwen, P. M., & Gros, P. (2020). Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F. Life Science Alliance, 3(11), Article e202000883. https://doi.org/10.26508/lsa.202000883
https://dspace.library.uu.nl/bitstream/handle/1874/408987/e202000883.full.pdf?sequence=1

de Bruijn, H. S., Mashayekhi, V., Schreurs, T. J. L., van Driel, P. B. A. A., Strijkers, G. J., van Diest, P. J., Lowik, C. W. G. M., Seynhaeve, A. L. B., Hagen, T. L. M. T., Prompers, J. J., Henegouwen, P. M. P. V. B. E., Robinson, D. J., & Oliveira, S. (2020). Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging. Theranostics, 10(5), 2436-2452. https://doi.org/10.7150/thno.37949
https://dspace.library.uu.nl/bitstream/handle/1874/396708/v10p2436.pdf?sequence=1

Deken, M. M., Kijanka, M. M., Beltrán Hernández, I., Slooter, M. D., de Bruijn, H. S., van Diest, P. J., van Bergen En Henegouwen, P. M. P., Lowik, C. W. G. M., Robinson, D. J., Vahrmeijer, A. L., & Oliveira, S. (2020). Nanobody-targeted photodynamic therapy induces significant tumor regression of trastuzumab-resistant HER2-positive breast cancer, after a single treatment session. Journal of controlled release : official journal of the Controlled Release Society, 323, 269-281. https://doi.org/10.1016/j.jconrel.2020.04.030
https://dspace.library.uu.nl/bitstream/handle/1874/396707/1_s2.0_S0168365920302443_main.pdf?sequence=1

2019

Scholarly publications

Frias, C. P., Liang, J., Bresser, T., Scheefhals, L., van Kesteren, M., van Dorland, R., Hu, H. Y., Bodzeta, A., van Bergen En Henegouwen, P. M. P., Hoogenraad, C. C., & Wierenga, C. J. (2019). Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation. Journal of Neuroscience, 39(22), 4221-4237. https://doi.org/10.1523/JNEUROSCI.0215-19.2019
https://dspace.library.uu.nl/bitstream/handle/1874/389464/4221.full.pdf?sequence=1

Beltrán Hernández, I., Rompen, R., Rossin, R., Xenaki, K. T., Katrukha, E. A., Nicolay, K., Henegouwen, P. V. B. E., Grüll, H., & Oliveira, S. (2019). Correction to Imaging of Tumor Spheroids, Dual-Isotope SPECT, and Autoradiographic Analysis to Assess the Tumor Uptake and Distribution of Different Nanobodies. Molecular Imaging and Biology, 22, Article 217. https://doi.org/10.1007/s11307-019-01355-0
https://dspace.library.uu.nl/bitstream/handle/1874/392300/Beltr_nHern_ndez2020_Article_CorrectionToImagingOfTumorSphe.pdf?sequence=1

Heukers, R., Mashayekhi, V., Ramirez-Escudero, M., de Haard, H., Verrips, T., van Bergen en Henegouwen, P., & Oliveira, S. (2019). VHH-Photosensitizer Conjugates for Targeted Photodynamic Therapy of Met-Overexpressing Tumor Cells. Antibodies, 8(2), Article 26. https://doi.org/10.3390/antib8020026
https://dspace.library.uu.nl/bitstream/handle/1874/384399/antibodies_08_00026_v2.pdf?sequence=1

Beltrán Hernández, I., Rompen, R., Rossin, R., Xenaki, K. T., Katrukha, E. A., Nicolay, K., van Bergen En Henegouwen, P., Grüll, H., & Oliveira, S. (2019). Imaging of Tumor Spheroids, Dual-Isotope SPECT, and Autoradiographic Analysis to Assess the Tumor Uptake and Distribution of Different Nanobodies. Molecular Imaging and Biology, 21, 1079–1088. https://doi.org/10.1007/s11307-019-01320-x
https://dspace.library.uu.nl/bitstream/handle/1874/392294/Beltr_nHern_ndez2019_Article_ImagingOfTumorSpheroidsDual_Is.pdf?sequence=1

2018

Scholarly publications

de Beer, M. A., Kuipers, J., van Bergen En Henegouwen, P. M. P., & Giepmans, B. N. G. (2018). A small protein probe for correlated microscopy of endogenous proteins. Histochemistry and Cell Biology, 149(3), 261-268. https://doi.org/10.1007/s00418-018-1632-6
https://dspace.library.uu.nl/bitstream/handle/1874/377569/small.pdf?sequence=1

Schooten, E., Di Maggio, A., van Bergen En Henegouwen, P. M. P., & Kijanka, M. M. (2018). MAGE-A antigens as targets for cancer immunotherapy. Cancer Treatment Reviews, 67, 54-62. https://doi.org/10.1016/j.ctrv.2018.04.009
https://dspace.library.uu.nl/bitstream/handle/1874/377568/1_s2.0_S0305737218300537_main.pdf?sequence=1

Zanetti-Domingues, L. C., Korovesis, D., Needham, S. R., Tynan, C. J., Sagawa, S., Roberts, S. K., Kuzmanic, A., Ortiz-Zapater, E., Jain, P., Roovers, R. C., Lajevardipour, A., van Bergen En Henegouwen, P. M. P., Santis, G., Clayton, A. H. A., Clarke, D. T., Gervasio, F. L., Shan, Y., Shaw, D. E., Rolfe, D. J., ... Martin-Fernandez, M. L. (2018). The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers. Nature Communications, 9(1), Article 4325. https://doi.org/10.1038/s41467-018-06632-0
https://dspace.library.uu.nl/bitstream/handle/1874/377567/s41467_018_06632_0.pdf?sequence=1

Mulder, C., Prust, N., Van Doorn, S., Reinecke, M., Kuster, B., Van Bergen En Henegouwen, P., & Lemeer, S. (2018). Adaptive resistance to EGFR-targeted therapy by calcium signaling in NSCLC cells. Molecular Cancer Research, 16(11), 1773-1784. https://doi.org/10.1158/1541-7786.MCR-18-0212
https://dspace.library.uu.nl/bitstream/handle/1874/374409/1773.full.pdf?sequence=1

Other output

Pereira Frias, C. S., Bresser, T., Scheefhals, L., van Bergen en Henegouwen, P. M. P., Hoogenraad, C. C., & Wierenga, C. J. (2018). Molecular pathway underlying bouton stabilization by Semaphorin4D during inhibitory synapse formation.. https://doi.org/10.1101/100271

2017

Scholarly publications

Ji, Y., Takanari, H., Qile, M., Nalos, L., Houtman, M. J. C., Romunde, F. L., Heukers, R., van Bergen en Henegouwen, P. M. P., Vos, M. A., & van der Heyden, M. A. G. (2017). Class III antiarrhythmic drugs amiodarone and dronedarone impair K_IR2.1 backward trafficking. Journal of Cellular and Molecular Medicine, 21(10), 2514-2523. https://doi.org/10.1111/jcmm.13172
https://dspace.library.uu.nl/bitstream/handle/1874/428496/J_Cellular_Molecular_Medi_2017_Ji_Class_III_antiarrhythmic_drugs_amiodarone_and_dronedarone_impair_KIR2_1_backward.pdf?sequence=1

de Bruin, R. C. G., Veluchamy, J. P., Lougheed, S. M., Schneiders, F. L., Lopez-Lastra, S., Lameris, R., Stam, A. G., Sebestyen, Z., Kuball, J., Molthoff, C. F. M., Hooijberg, E., Roovers, R. C., Santo, J. P. D., van Bergen En Henegouwen, P. M. P., Verheul, H. M. W., de Gruijl, T. D., & van der Vliet, H. J. (2017). A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells. OncoImmunology, 7(1), Article e1375641. https://doi.org/10.1080/2162402X.2017.1375641
https://dspace.library.uu.nl/bitstream/handle/1874/428494/A_bispecific_nanobody_approach_to_leverage_the_potent_and_widely_applicable_tumor_cytolytic_capacity_of_V_9V_2_T_cells.pdf?sequence=1

Harwood, S. L., Alvarez-Cienfuegos, A., Nuñez-Prado, N., Compte, M., Hernández-Pérez, S., Merino, N., Bonet, J., Navarro, R., Van Bergen En Henegouwen, P. M. P., Lykkemark, S., Mikkelsen, K., Mølgaard, K., Jabs, F., Sanz, L., Blanco, F. J., Roda-Navarro, P., & Alvarez-Vallina, L. (2017). ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy. OncoImmunology, 7(1), Article e1377874. https://doi.org/10.1080/2162402X.2017.1377874
https://dspace.library.uu.nl/bitstream/handle/1874/428495/ATTACK_a_novel_bispecific_T_cell_recruiting_antibody_with_trivalent_EGFR_binding_and_monovalent_CD3_binding_for_cancer_immunotherapy.pdf?sequence=1

Kijanka, M., van Donselaar, E. G., Müller, W. H., Dorresteijn, B., Popov-Celeketic, D., El Khattabi, M., Verrips, C. T., van Bergen En Henegouwen, P. M. P., & Post, J. A. (2017). A novel immuno-gold labeling protocol for nanobody-based detection of HER2 in breast cancer cells using immuno-electron microscopy. Journal of Structural Biology, 199(1), 1-11. https://doi.org/10.1016/j.jsb.2017.05.008
https://dspace.library.uu.nl/bitstream/handle/1874/359369/1_s2.0_S1047847717300886_main.pdf?sequence=1

Xenaki, K. T., Oliveira, S., & van Bergen En Henegouwen, P. M. P. (2017). Antibody or Antibody Fragments: Implications for Molecular Imaging and Targeted Therapy of Solid Tumors. Frontiers in Immunology, 8, 1287. https://doi.org/10.3389/fimmu.2017.01287
https://dspace.library.uu.nl/bitstream/handle/1874/359772/fimmu_08_01287.pdf?sequence=1

Katrukha, E. A., Mikhaylova, M., van Brakel, H. X., van Bergen En Henegouwen, P. M., Akhmanova, A., Hoogenraad, C. C., & Kapitein, L. C. (2017). Probing cytoskeletal modulation of passive and active intracellular dynamics using nanobody-functionalized quantum dots. Nature Communications, 8, Article 14772. https://doi.org/10.1038/ncomms14772
https://dspace.library.uu.nl/bitstream/handle/1874/359344/Probing.pdf?sequence=1

de Bruin, R. C. G., Stam, A. G. M., Vangone, A., van Bergen En Henegouwen, P. M. P., Verheul, H. M. W., Sebestyén, Z., Kuball, J., Bonvin, A. M. J. J., de Gruijl, T. D., & van der Vliet, H. J. (2017). Correction: Prevention of Vγ9Vδ2 T Cell Activation by a Vγ9Vδ2 TCR Nanobody. Journal of Immunology, 198(9), 3759. https://doi.org/10.4049/jimmunol.1700317
https://dspace.library.uu.nl/bitstream/handle/1874/349696/3759.full.pdf?sequence=1

2016

Scholarly publications

Qiu, X., Wegner, K. D., Wu, Y. T., Van Bergen En Henegouwen, P. M. P., Jennings, T. L., & Hildebrandt, N. (2016). Nanobodies and antibodies for duplexed EGFR/HER2 immunoassays using terbium-to-quantum dot FRET. Chemistry of Materials, 28(22), 8256-8267. https://doi.org/10.1021/acs.chemmater.6b03198
https://dspace.library.uu.nl/bitstream/handle/1874/428498/acs.chemmater.6b03198.pdf?sequence=1

Afsari, H. S., Cardoso Dos Santos, M., Lindén, S., Chen, T., Qiu, X., van Bergen En Henegouwen, P. M. P., Jennings, T. L., Susumu, K., Medintz, I. L., Hildebrandt, N., & Miller, L. W. (2016). Time-gated FRET nanoassemblies for rapid and sensitive intra- and extracellular fluorescence imaging. Science advances, 2(6), Article e1600265. https://doi.org/10.1126/sciadv.1600265
https://dspace.library.uu.nl/bitstream/handle/1874/343696/FRET.pdf?sequence=1

de Bruin, R. C. G., Stam, A. G. M., Vangone, A., van Bergen En Henegouwen, P. M. P., Verheul, H. M. W., Sebestyén, Z., Kuball, J., Bonvin, A. M. J. J., de Gruijl, T. D., & van der Vliet, H. J. (2016). Prevention of Vγ9Vδ2 T Cell Activation by a Vγ9Vδ2 TCR Nanobody. Journal of Immunology, 198, 308-317. https://doi.org/10.4049/jimmunol.1600948
https://dspace.library.uu.nl/bitstream/handle/1874/344101/Prevention.pdf?sequence=1

Kooijmans, S. A. A., Fliervoet, L. A. L., Van Der Meel, R., Fens, M. H. A. M., Heijnen, H. F. G., Van Bergen En Henegouwen, P. M. P., Vader, P., & Schiffelers, R. M. (2016). PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time. Journal of Controlled Release, 224, 77-85. https://doi.org/10.1016/j.jconrel.2016.01.009
https://dspace.library.uu.nl/bitstream/handle/1874/343695/PEGylated.pdf?sequence=1

de Bruin, R. C. G., Lougheed, S. M., van der Kruk, L., Stam, A. G., Hooijberg, E., Roovers, R. C., van Bergen en Henegouwen, P. M. P., Verheul, H. M. W., de Gruijl, T. D., & van der Vliet, H. J. (2016). Highly specific and potently activating Vγ9Vδ2-T cell specific nanobodies for diagnostic and therapeutic applications. Clinical Immunology, 169, 128-138. https://doi.org/10.1016/j.clim.2016.06.012
https://dspace.library.uu.nl/bitstream/handle/1874/344460/Highly.pdf?sequence=1

Lameris, R., de Bruin, R. C. G., van Bergen en Henegouwen, P. M. P., Verheul, H. M., Zweegman, S., de Gruijl, T. D., & van der Vliet, H. J. (2016). Generation and characterization of CD1d-specific single-domain antibodies with distinct functional features. Immunology, 149(1), 111-121. https://doi.org/10.1111/imm.12635
https://dspace.library.uu.nl/bitstream/handle/1874/346805/generation.pdf?sequence=1

Salema, V., Mañas, C., Cerdán, L., Piñero-Lambea, C., Marín, E., Roovers, R. C., Van Bergen en Henegouwen, P. M. P., & Fernández, L. Á. (2016). High affinity nanobodies against human epidermal growth factor receptor selected on cells by E. coli display. mAbs, 8(7), 1286-1301. https://doi.org/10.1080/19420862.2016.1216742
https://dspace.library.uu.nl/bitstream/handle/1874/345033/nanobodies.pdf?sequence=1

Kaplan, M., Narasimhan, S., de Heus, C., Mance, D., van Doorn, S., Houben, K., Popov-Celeketic, D., Damman, R., Katrukha, E. A., Jain, P., Geerts, W. J. C., Heck, A. J. R., Folkers, G. E., Kapitein, L. C., Lemeer, S., van Bergen En Henegouwen, P. M. P., & Baldus, M. (2016). EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR. Cell, 167(5), 1241-1251.e11. https://doi.org/10.1016/j.cell.2016.10.038
https://dspace.library.uu.nl/bitstream/handle/1874/344097/EGFR.pdf?sequence=1

Kijanka, M. M., van Brussel, A. S. A., van der Wall, E., Mali, W. P. T. M., van Diest, P. J., van Bergen en Henegouwen, P., & Oliveira, S. (2016). Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization. EJNMMI Research, 6(1). https://doi.org/10.1186/s13550-016-0166-y
https://dspace.library.uu.nl/bitstream/handle/1874/344448/optical.pdf?sequence=1

van Driel, P. B. A. A., Boonstra, M. C., Slooter, M. D., Heukers, R., Stammes, M. A., Snoeks, T. J. A., de Bruijn, H. S., van Diest, P. J., Vahrmeijer, A. L., van Bergen En Henegouwen, P. M. P., van de Velde, C. J. H., Löwik, C. W. G. M., Robinson, D. J., & Oliveira, S. (2016). EGFR targeted nanobody-photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer. Journal of Controlled Release, 229, 93-105. https://doi.org/10.1016/j.jconrel.2016.03.014
https://dspace.library.uu.nl/bitstream/handle/1874/343679/EGFR.pdf?sequence=1

Broekgaarden, M., Van Vught, R., Oliveira, S., Roovers, R. C., Van Bergen En Henegouwen, P. M. P., Pieters, R. J., Van Gulik, T. M., Breukink, E., & Heger, M. (2016). Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy. Nanoscale, 8(12), 6490-6494. https://doi.org/10.1039/c6nr00014b
https://dspace.library.uu.nl/bitstream/handle/1874/339445/c6nr00014b.pdf?sequence=1

van Brussel, A. S. A., Adams, A., Oliveira, S., Dorresteijn, B., El Khattabi, M., Vermeulen, J. F., van der Wall, E., Mali, W. P. T. M., Derksen, P. W. B., van Diest, P. J., & van Bergen En Henegouwen, P. M. P. (2016). Hypoxia-Targeting Fluorescent Nanobodies for Optical Molecular Imaging of Pre-Invasive Breast Cancer. Molecular Imaging and Biology, 18(4), 535–544. https://doi.org/10.1007/s11307-015-0909-6
https://dspace.library.uu.nl/bitstream/handle/1874/345907/Fluorescent.pdf?sequence=1

2015

Scholarly publications

Navis, A. C., van Lith, S. A. M., van Duijnhoven, S. M. J., de Pooter, M., Yetkin-Arik, B., Wesseling, P., Hendriks, W. J. A. J., Venselaar, H., Timmer, M., van Cleef, P., van Bergen En Henegouwen, P., Best, M. G., Wurdinger, T. D., Tops, B. B. J., & Leenders, W. P. J. (2015). Identification of a novel MET mutation in high-grade glioma resulting in an auto-active intracellular protein. Acta Neuropathologica, 130(1), 131-44. https://doi.org/10.1007/s00401-015-1420-5
https://dspace.library.uu.nl/bitstream/handle/1874/428497/s00401_015_1420_5.pdf?sequence=1

Heukers, R., Van Bergen en Henegouwen, P. M. P., & Oliveira, S. (2015). Nanobody-fotosensibilisatorconjugaten voor gerichte fotodynamische therapie. Pharmaceutisch Weekblad, 150(38), 184-196.
https://dspace.library.uu.nl/bitstream/handle/1874/428489/8f735b8adb9ee66740b6577a54bdcad0_2015wp0184.pdf?sequence=1

Kijanka, M., Dorresteijn, B., Oliveira, S., & van Bergen en Henegouwen, P. M. P. (2015). Nanobody-based cancer therapy of solid tumors. Nanomedicine (London), 10(1), 161-74. https://doi.org/10.2217/nnm.14.178
https://dspace.library.uu.nl/bitstream/handle/1874/330269/solid.pdf?sequence=1

Mikhaylova, M., Cloin, B. M. C., Finan, K., van den Berg, R., Teeuw, J., Kijanka, M. M., Sokolowski, M., Katrukha, E. A., Maidorn, M., Opazo, F., Moutel, S., Vantard, M., Perez, F., van Bergen en Henegouwen, P. M. P., Hoogenraad, C. C., Ewers, H., & Kapitein, L. C. (2015). Resolving bundled microtubules using anti-tubulin nanobodies. Nature Communications [E], 6, Article 7933. https://doi.org/10.1038/ncomms8933
https://dspace.library.uu.nl/bitstream/handle/1874/324920/33.pdf?sequence=1

2014

Scholarly publications

Van Driel, P. B. A. A., Van Der Vorst, J. R., Verbeek, F. P. R., Oliveira, S., Snoeks, T. J. A., Keereweer, S., Chan, B., Boonstra, M. C., Frangioni, J. V., Van Bergen En Henegouwen, P. M. P., Vahrmeijer, A. L., & Lowik, C. W. G. M. (2014). Intraoperative fluorescence delineation of head and neck cancer with a fluorescent Anti-epidermal growth factor receptor nanobody. International Journal of Cancer, 134(11), 2663-2673. https://doi.org/10.1002/ijc.28601

Wegner, K. D., Linden, S., Jin, Z., Jennings, T. L., el Khoulati, R., van Bergen en Henegouwen, P., & Hildebrandt, N. (2014). Nanobodies and nanocrystals: highly sensitive quantum dot-based homogenous FRET immunoassay for serum-based EGFR detection. Small: nano micro, 10(4), 734-740. https://doi.org/10.1002/smll.201302383

Popov-Celeketic, D., & van Bergen en Henegouwen, P. (2014). Membrane domain formation - a key factor for targeted intracellular drug delivery. Frontiers in Physiology [E], 5, 462. https://doi.org/10.3389/fphys.2014.00462
https://dspace.library.uu.nl/bitstream/handle/1874/307475/fphys_05_00462.pdf?sequence=1

Lameris, R., de Bruin, R., Schneiders, F. L., van Bergen en Henegouwen, P., Verheul, H. M., de Gruijl, T. D., & van der Vliet, H. J. (2014). Bispecific antibody platforms for cancer immunotherapy. Critical Reviews in Oncology Hematology, 92, 153-165. https://doi.org/10.1016/j.critrevonc.2014.08.003

Heukers, R., van Bergen en Henegouwen, P., & Oliveira, S. (2014). Nanobody-photosensitizer conjugates for targeted photodynamic therapy. Nanomedicine : nanotechnology, biology and medicine, 10(7), 1441-1451. https://doi.org/10.1016/j.nano.2013.12.007

Heukers, R., Altintas, I., Raghoenath, S., De Zan, E., Pepermans, R., Roovers, R. C., Haselberg, R., Hennink, W. E., Schiffelers, R. M., Kok, R. J., & Van Bergen en Henegouwen, P. M. P. (2014). Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles. Biomaterials, 35(1), 601-610. https://doi.org/10.1016/j.biomaterials.2013.10.001

Hagemeijer, M. C., Monastyrska, I., Griffith, J., van der Sluijs, P., Voortman, J., van Bergen en Henegouwen, P. M., Vonk, A. M., Rottier, P. J. M., Reggiori, F. M., & De Haan, C. A. M. (2014). Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4. Virology, 458-459, 125-135. https://doi.org/10.1016/j.virol.2014.04.027
https://dspace.library.uu.nl/bitstream/handle/1874/310408/membrane.pdf?sequence=1

2013

Scholarly publications

van der Meel, R., Oliveira, S., Altintas, I., Heukers, R., Pieters, E. H. E., van Bergen en Henegouwen, P. M. P., Storm, G., Hennink, W., Kok, R. J., & Schiffelers, R. M. (2013). Inhibition of tumor growth by targeted anti-EGFR/IGF-1R nanobullets depends on efficient blocking of cell survival pathways. Molecular Pharmaceutics, 10(10), 3717-27. https://doi.org/10.1021/mp400212v

Oliveira, S., Heukers, R., Sornkom, J., Kok, R. J., & van Bergen En Henegouwen, P. M. P. (2013). Targeting tumors with nanobodies for cancer imaging and therapy. Journal of Controlled Release, 172(3), 607-17. https://doi.org/10.1016/j.jconrel.2013.08.298

Altintas, I., Heukers, R., van der Meel, R., Lacombe, M., Amidi, M., van Bergen en Henegouwen, P. M. P., Hennink, W. E., Schiffelers, R. M., & Kok, R. J. (2013). Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells. Journal of Controlled Release, 165(2), 110-118. http://www.ncbi.nlm.nih.gov/pubmed/23159529

Varkevisser, R., Houtman, M. J. C., Waasdorp, M., Man, J. C., Heukers, R., Takanari, H., Tieland, R. G., van Bergen en Henegouwen, P. M. P., Vos, M. A., & van der Heyden, M. A. (2013). Inhibiting the clathrin-mediated endocytosis pathway rescues (KIR)2.1 downregulation by pentamidine. Pflugers Archiv-European Journal of Physiology, 465(2), 247-259.

Heukers, R., Vermeulen, P. J., Fereidouni, F., Bader, A. N., Voortman, J., Roovers, R. C., Gerritsen, H. C., & van Bergen en Henegouwen, P. M. P. (2013). Endocytosis of EGFR requires its kinase activity and N-terminal transmembrane dimerization motif. Journal of Cell Science, 126(21), 4900-4912. https://doi.org/10.1242/?jcs.128611
https://dspace.library.uu.nl/bitstream/handle/1874/289203/HeukersEndocytosis.pdf?sequence=1

van Brussel, A. S. A., Adams, A. L. L., Vermeulen, J. F., Oliveira, S., van der Wall, E., Mali, W. P. T. M., van Diest, P. J., & van Bergen en Henegouwen, P. M. P. (2013). Molecular imaging with a fluorescent antibody targeting carbonic anhydrase IX can successfully detect hypoxic ductal carcinoma in situ of the breast. Breast Cancer Research and Treatment, 140(2), 263-272. https://doi.org/10.1007/s10549-013-2635-6

Zaiss, D. M. W., van Loosdregt, J., Gorlani, A., Bekker, C. P. J., Gröne, A., Sibilia, M., van Bergen en Henegouwen, P. M. P., Roovers, R. C., Coffer, P. J., & Sijts, E. J. A. M. (2013). Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor. Immunity, 38(2), 275-284. https://doi.org/10.1016/j.immuni.2012.09.023

Schmitz, K. R., Bagchi, A., Roovers, R. C., van Bergen en Henegouwen, P. M. P., & Ferguson, K. M. (2013). Structural evaluation of EGFR inhibition mechanisms for nanobodies/VHH domains. Structure, 71(7), 1212-1224.

de Heus, C., Kagie, N., Heukers, R., van Bergen en Henegouwen, P. M. P., & Gerritsen, H. C. (2013). Analysis of EGF receptor oligomerization by homo-FRET. Molecular and Cellular Proteomics, 117, 305-321. https://doi.org/10.1016/B978-0-12-408143-7.00016-5

Kijanka, M. M., Warnders, F. J., el Khattabi, M., Lub-de Hooge, M. N., van Dam, G. M., Ntziachristos, V., de Vries, L., Oliveira, S., & van Bergen en Henegouwen, P. M. P. (2013). Rapid optical imaging of human breast tumour xenografts using anti-HER2 VHHs site-directly conjugated to IRDye 800CW for image-guided surgery. European Journal of Nuclear Medicine and Molecular Imaging, 40(11), 1718-1729. http://10.1007/s00259-013-2471-2

Wegner, K. D., van der Linden, R. H. J., Jin, Z., Jennings, T. L., el Khoulati, R., van Bergen en Henegouwen, P. M. P., Hildebrandt, N., & Linden, S. (2013). Nanobodies and nanocrystals: Highly sensitive quantum dot-based homogeneous FRET immunoassay for serum-based EGFR detection. Small: nano micro.

Other output

Heukers, R., de Heus, C., Fereidouni, F., Bader, A. N., Voortman, J., Roovers, R. C., Gerritsen, H. C., & van Bergen en Henegouwen, P. M. P. (2013). EGFR clustering induces its CME which requires the N-terminal TMD dimerization motif. Poster session presented at ICREA, Visualizing signaling nanoplatforms at a higher spatiotemporal resolution.

Heukers, R., de Heus, C., Fereidouni, F., Bader, A. N., Voortman, J., Roovers, R. C., Gerritsen, H. C., & van Bergen en Henegouwen, P. M. P. (2013). A role for the N-terminal transmembrane dimerization motif of EGFR in internalization.. Poster session presented at EMBO Meeting, Amsterdam, The Netherlands.

Oliveira, S., van Driel, P. B. A. A., van der Vorst, J. R., Vahrmeijer, A. L., Lowik, C. W., & van Bergen en Henegouwen, P. M. P. (2013). From rapid visualization of subcutaneous tumors to the delineation of primary orthotopic oral squamous cell carcinomas and microscopic lymph node metastases.. Poster session presented at EMIM, Turijn, Italy.

Mikhaylova, M., Katrukha, Y., Brakel, H. X., van Bergen en Henegouwen, P. M. P., Akhmanova, A. S., Hoogenraad, C. C., & Kapitein, L. C. (2013). Inducible targeting of cytoplasmic quantum dots.. Poster session presented at Dutch meeting on Molecular and Cellular Biophysics, Veldhoven, The Netherlands.

Heukers, R., Vermeulen, J. F., Fereidouni, F., Bader, A. N., Voortman, J., Roovers, R. C., Gerritsen, H. C., & van Bergen en Henegouwen, P. M. P. (2013). EGFR clustering induces its clathrin-mediated endocytosis.. Poster session presented at IIAS-ISF Conference on “Epidermal growth Factor Receptor - Future Directions”., Jerusalem, Israel.

2012

Scholarly publications

Van Der Meel, R., Oliveira, S., Altintas, I., Haselberg, R., Roovers, R. C., Van Bergen en Henegouwen, P. M. P., Hennink, W. E., Storm, G., Schiffelers, R. M., & Kok, R. J. (2012). Tumor-targeted nanobullets for anti-cancer combination therapy. European Journal of Cancer, 48, 38. https://doi.org/10.1016/S0959-8049(12)71919-6

Oliveira, S., van Dongen, G. A. M. S., Stigter-van Walsum, M., Roovers, R. C., Stam, J. C., Mali, W. P. T. M., van Diest, P. J., & van Bergen en Henegouwen, P. M. P. (2012). Rapid visualization of human tumor xenografts through optical imaging with a near-infrared fluorescent anti-epidermal growth factor receptor nanobody. Molecular Imaging, 11(1), 33-46. http://www.ncbi.nlm.nih.gov/pubmed/22418026

Oliveira, S., Cohen, R., Stigter-van Walsum, M., van Dongen, G. A. M. S., Elias, S. G., van Diest, P. J., Mali, W. P. T. M., & van Bergen en Henegouwen, P. M. P. (2012). A novel method to quantify IRDye800CW fluorescent antibody probes ex vivo in tissue distribution studies. EJNMMI research [E], 2(1), 1-9. https://doi.org/10.1186/2191-219X-2-50
https://dspace.library.uu.nl/bitstream/handle/1874/272343/2191-219X-2-50.pdf?sequence=1

van der Meel, R., Oliveira, S., Altintas, I., Haselberg, R., van der Veeken, J., Roovers, R. C., van Bergen en Henegouwen, P. M. P., Storm, G., Hennink, W. E., Schiffelers, R. M., & Kok, R. J. (2012). Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment. Journal of Controlled Release, 159(2), 281-9. http://www.ncbi.nlm.nih.gov/pubmed/22227023

van de Water, J. A. J. M., Bagci-Onder, T., Agarwal, A. S., Wakimoto, H., Roovers, R. C., Zhu, Y., Kasmieh, R., Bhere, D., van Bergen en Henegouwen, P. M. P., & Shah, K. (2012). Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects. Proceedings of the National Academy of Sciences of the United States of America, 109(41), 16642-16647. https://doi.org/10.1073/pnas.1202832109

Altintas, I., Heukers, R., van der Meel, R., Lacombe, M., Amidi, M., van Bergen en Henegouwen, P. M. P., Hennink, W. E., Schiffelers, R. M., & Kok, R. J. (2012). Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells. Cell Biology International, 165(2), 110-118. https://doi.org/10.1016/j.jconrel.2012.11.007

Other output

Mania, M. M., Oliveira, S., el Khattabi, M., & van Bergen en Henegouwen, P. M. P. (2012). Development of NIT fluorescent antiHER2 VHHs for breast cancer imaging. Abstract from NWO CW meeting, Veldhoven.

Mania, M. M., Oliveira, S., el Khattabi, M., & van Bergen en Henegouwen, P. M. P. (2012). Development of NIT fluorescent antiHER2 VHHs for breast cancer imaging. Abstract from WMIC 2012, Dublin, Ireland.

Oliveira, S., Cohen, R., Stigter-van Walsum, M., van Dongen, G. A., Sjoerd Elias, M. S., van Diest, P. J., Mali, W., & van Bergen en Henegouwen, P. M. P. (2012). Development of NIT fluorescent antiHER2 VHHs for breast cancer imaging. Abstract from WMIC 2012, Dublin, Ireland.

Oliveira, S., Cohen, R., Stigter-van Walsum, M., van Dongen, G. A. M. S., Elias, S. G., van Diest, P. J., Mali, W., & van Bergen en Henegouwen, P. M. P. (2012). A novel method to quantifyIRDye800CW-fluorescent antibody probes ex vivo in tissue distribution studies. Poster session presented at CTMM annual meeting, Utrecht.

Oliveira, S., Cohen, R., Stigter-van Walsum, M., van Dongen, G. A. M. S., Elias, S. G., van Diest, P. J., Mali, W., & van Bergen en Henegouwen, P. M. P. (2012). A novel method to quantifyIRDye800CW-fluorescent antibody probes ex vivo in tissue distribution studies. Abstract from World Molecular Imaging Congress & European Molecular Imaging Meeting, Dublin, Ireland.

Mania, M. M., Oliveira, S., el Khattabi, M., & van Bergen en Henegouwen, P. M. P. (2012). Development of NIT fluorescent antiHER2 VHHs for breast cancer imaging. Poster session presented at NWO CW meeting, Veldhoven.

Heukers, R., Vermeulen, J., Fereidouni, F., Bader, A., Gerritsen, H. C., Roovers, R. C., & van Bergen en Henegouwen, P. M. P. (2012). EGFR clustering induces its CME and degradation and is sufficient to inhibit proliferation. Abstract from Beatson International Cancer Conference, Glasgow, UK.

2011

Scholarly publications

Talelli, M., Rijcken, C. J. F., Santos Oliveira, S., van der Meel, R., van Bergen en Henegouwen, P. M. P., Lammers, T., van Nostrum, C. F., Storm, G., & Hennink, W. E. (2011). Reprint of "Nanobody--shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting". Journal of Controlled Release, 153(1), 93-102. https://doi.org/10.1016/j.jconrel.2011.06.003

Roovers, R. C., Vosjan, M. J., Laeremans, T., el Khoulati, R., de Bruin, R. C. G., Ferguson, K. M., Verkleij, A. J., van Dongen, G. A., & van Bergen en Henegouwen, P. M. P. (2011). A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth. International Journal of Cancer, 129(8), 2013-2024.

Talelli, M., Rijcken, J. F., Oliveira, S., Meel, R., van Bergen en Henegouwen, P. M. P., Lammers, T., van Nostrum, C. F., Storm, G., & Hennink, W. E. (2011). Nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting. Journal of Controlled Release, 151(2), 183-192.

Low-Nam, S. T., Lidke, K. A., Cutler, P. J., Roovers, R. C., van Bergen en Henegouwen, P. M. P., Wilson, B. S., & Lidke, D. S. (2011). ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding. Nature Structural and Molecular Biology, 18(11), 1244-1249.

Elstak, E. D. R., Neeft, M. A., Nehme, N. T., Voortman, J., Cheung, M., Goodarzifard, M., Gerritsen, H. C., van Bergen en Henegouwen, P. M. P., Callebaut, I., de Saint Basile, G., & van der Sluijs, P. (2011). The munc13-4–rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane. Blood, 118(6), 1570-1578. https://doi.org/10.1182/blood-2011-02-339523

Vosjan, M. J., Perk, L. R., Roovers, R. C., Visser, G. W. M., Stigter-van Walsum, M., van Bergen en Henegouwen, P. M. P., & van Dongen, G. A. M. S. (2011). Facile labelling of an anti-epidermal growth factor receptor Nanobody with 68Ga via a novel bifunctional desferal chelate for immuno-PET. European Journal of Nuclear Medicine and Molecular Imaging, 38(4), 753-763.

Other output

Oliveira, S., van Dongen, G. A. M. S., Stigter-van Walsum, S., Mali, W., van Diest, P. J., & van Bergen en Henegouwen, P. M. P. (2011). Rapid visualization of human tumor xenografts through optical imaging with a near-infrared fluorescent anti-EGFR nanobody. Abstract from 6th European Molecular Imaging Meeting, Leiden, The Netherlands.

Mania, M. M., Oliveira, S., el Khattabi, M., & van Bergen en Henegouwen, P. M. P. (2011). Development of NIR fluorescent anait-HER2 VHHs for breast cancer imaging. Abstract from Annual Meeting CTTM, Utrecht.

Mania, M. M., Oliveira, S., el Khattabi, M., & van Bergen en Henegouwen, P. M. P. (2011). Development of NIR fluorescent anait-HER2 VHHs for breast cancer imaging. Poster session presented at Annual Meeting CTTM, Utrecht.

van Bergen en Henegouwen, P. M. P., Hofman, E. G., Bader, A. N., Voortman, J., van den Heuvel, D. J., Sigismund, S., & Gerritsen, H. C. (2011). Ligand-induced EGF receptor oligomerization is kinse=dependent and enhances internalization. Poster session presented at Förster Resonance Energy Transfer in Life Sciences, Göttingen, Germany.

Oliveira, S., van Dongen, G. A. M. S., Stigter-van Walsum, S., Mali, W., van Diest, P. J., & van Bergen en Henegouwen, P. M. P. (2011). Preclinical optical molecular imaging with near-infrared fluorescent probes: a comparative study between an anti-EGFR nanobody and a monoclonal antibody. Poster session presented at 4th World Molecular Imaging Conference, San Diego, California, USA.

van Brussel, A. S. A., Oliveira, S., Vermeulen, J. F., van der Wall, E., van Bergen en Henegouwen, P. M. P., & van Diest, P. J. (2011). Hypoxia-dependent surface markers for imaging of breast cancer. Abstract from Annual Meeting CTMM 2011, Utrecht.

van Bergen en Henegouwen, P. M. P., Hofman, E. G., Bader, A. N., Voortman, J., van den Heuvel, D. J., Sigismund, S., & Gerritsen, H. C. (2011). Ligand-induced EGF receptor oligomerization is kinse=dependent and enhances internalization. Abstract from Förster Resonance Energy Transfer in Life Sciences, Göttingen, Germany.

Laeremans, T., van Bergen en Henegouwen, P. M. P., Silence, K., & Vaeck, M. (2011). Single domain antibodies directed against epidermal growth factor receptor and uses therefor. (Patent No. 2011018151 (patent)).

Silence, K., Vaeck, M., & van Bergen en Henegouwen, P. M. P. (2011). Method of administering therapeutic polypeptides and polypeptides therefor. (Patent No. 2011018145 (patent)).

Oliveira, S., van Dongen, G. A. M. S., Stigter-van Walsum, S., Mali, W., van Diest, P. J., & van Bergen en Henegouwen, P. M. P. (2011). Preclinical optical molecular imaging with near-infrared fluorescent probes: a comparative study between an anti-EGFR nanobody and a monoclonal antibody. Abstract from 4th World Molecular Imaging Conference, San Diego, California, USA.

Oliveira, S., van Dongen, G. A. M. S., Stigter-van Walsum, S., Mali, W., van Diest, P. J., & van Bergen en Henegouwen, P. M. P. (2011). Rapid visualization of human tumor xenografts through optical imaging with a near-infrared fluorescent anti-EGFR nanobody. Poster session presented at 6th European Molecular Imaging Meeting, Leiden, The Netherlands.

2010

Scholarly publications

Bader, A. N., Hoetzl, S., Hofman, E. G., Voortman, J., van Bergen en Henegouwen, P. M. P., van Meer, G., & Gerritsen, H. C. (2010). Homo-FRET Imaging as a tool to quantify protein and lipid clustering. ChemPhysChem, 12(3), 475-483. https://doi.org/10.1002/cphc.201000801
https://dspace.library.uu.nl/bitstream/handle/1874/196754/ChemPhysChem_12_2010.pdf?sequence=1

Hofman, E. G., Bader, A. N., Voortman, J., van den Heuvel, D. J., Sigismund, S., Verkleij, A. J., Gerritsen, H. C., & van Bergen en Henegouwen, P. M. P. (2010). Ligand-induced EGF receptor oligomerization is kinase-dependent and enhances internalization. Journal of Biological Chemistry, 285(50), 39481-39489. https://doi.org/0.1074/jbc.M110.164731
https://dspace.library.uu.nl/bitstream/handle/1874/202240/Ligand-induced_Hofman_2010.pdf?sequence=1

Oliveira, S., Schiffelers, R. M., van der Veeken, J., van der Meel, R., Vongpromek, R., van Bergen en Henegouwen, P. M. P., Storm, G., & Roovers, R. C. (2010). Downregulation of EGFR by a novel multivalent nanobody-liposome platform. Journal of Controlled Release, 145(2), 165-175. http://10.1016/j.jconrel.2010.03.020

Other output

Voortman, J., Bader, A. N., Gerritsen, H. C., & van Bergen en Henegouwen, P. M. P. (2010). Actin-dependent EGFR trafficking in living cells. Poster session presented at Annual Dutch meeting on Molecular and Cellular Biophysics, Veldhoven.

2009

Scholarly publications

Van Bergen En Henegouwen, P. M. P. (2009). Eps15: A multifunctional adaptor protein regulating intracellular trafficking. Cell Communication and Signaling, 7, Article 24. https://doi.org/10.1186/1478-811X-7-24

Hamelers, I. H. L., Staffhorst, R. W. H. M., Voortman, J., de Kruijff, B., Reedijk, J., van Bergen en Henegouwen, P. M. P., & de Kroon, A. I. P. M. (2009). High cytotoxicity of cisplatin nanocapsules in ovarian carcinoma cells depends on uptake by caveolae-mediated endocytosis. Clinical Cancer Research, 15(4), 1259-1268.

Hofman, E. G., Bader, A. N., Gerritsen, H. C., & van Bergen en Henegouwen, P. M. P. (2009). EGF induces rapid reorganization of plasma membrane microdomains. Communicative & Integrative Biology, 2(3), 213-214.

Hamelers, I. H. L., Staffhorst, R. W. H. M., Voortman, J., de Kruijff, B., Reedijk, J., van Bergen en Henegouwen, P. M. P., & de Kroon, A. I. P. M. (2009). High cytotoxicity of cisplatin nanocapsules in ovarian carcinoma celles depends on uptake by caveolae-mediated endocytosis. Clinical Cancer Research, 15, 1259-1268.

2008

Scholarly publications

Hofman, E. G., Ruonala, M. O., Bader, AN., van den Heuvel, D., Voortman, J., Roovers, R. C., Verkleij, A. J., Gerritsen, H. C., & van Bergen en Henegouwen, P. M. P. (2008). EGF induced coalescence of different lipid rafts. Journal of Cell Science, 121, 2519-2528.

Agronskaia, A. V., Valentijn, J. A., Driel, L. F., Schneijdenberg, C. T. W. M., Humbel, B. M., van Bergen en Henegouwen, P. M. P., Verkleij, A. J., Koster, A. J., & Gerritsen, H. C. (2008). Integrated fluorescence and transmission electron microscopy: a novel approach to correlative microscopy. Journal of Structural Biology, 164, 183-189.

Hofman, E. G., Ruonala, O., Bader, A. N., van den Heuvel, D., Voortman, J., Verkleij, A. J., Gerritsen, H. C., & van Bergen en Henegouwen, P. M. P. (2008). EGF induces coalescence of different lipid rafts. Journal of Cell Science, 121, 2519-2528.
https://dspace.library.uu.nl/bitstream/handle/1874/32756/jcs.028753v1.pdf?sequence=1

2007

Scholarly publications

Bader, A. N., Hofman, E. G., Van Bergen En Henegouwen, P., & Gerritsen, H. C. (2007). Confocal time-resolved fluorescence anisotropy imaging. In Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V Article 64410C (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6441). https://doi.org/10.1117/12.702031

Roovers, R. C., van Dongen, G. A., & van Bergen en Henegouwen, P. M. P. (2007). Nanobodies in therapeutic applications. Current Opinion in Molecular Therapeutics, 9, 327-335.

Roovers, R. C., Laeremans, T., Huang, L., De Taye, S., Verkleij, A. J., Revets, H., Haard, H., & van Bergen en Henegouwen, P. M. P. (2007). Efficient inhibition of EGFR signalling and of tumour growth by antagonistic anti-EGFR nanobodies. Cancer Immunology, Immunotherapy, 56, 303-317.

2006

Scholarly publications

Oliveira, S., van Bergen en Henegouwen, P. M. P., Storm, G., & Schiffelers, R. M. (2006). Molecular biology of epidermal growth factor receptor inhibition for cancer therapy. Expert Opinion on Biological Therapy, 6, 605-617.

Fallon, L., Belanger, C. M. L., Corera, A. T., Kontogiannea, M., Regan-Klapisz, E. E., Moreau, F., Voortman, J., Haber, M., Rouleau, G., Thorarinsdottir, T., Beice, A., van Bergen en Henegouwen, P. M. P., & Fon, E. A. (2006). A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signaling. Nature Cell Biology, 8, 834-844.

2005

Scholarly publications

Abulrob, A., Sprong, H., van Bergen en Henegouwen, P. M. P., & Stanimirovic, D. (2005). The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells. Journal of Neurochemistry, 95, 1201-1214.
https://dspace.library.uu.nl/bitstream/handle/1874/14743/1.Abulrob2005%2520pp1201-1214.pdf?sequence=1

Regan-Klapisz, E. E., Sorokina, I., Voortman, J., Keizer, P., Roovers, R. C., Verheesen, P., Urbe, S., Fallon, L., Fon, E. A., Verkleij, A. J., Benmerah, A., & van Bergen en Henegouwen, P. M. P. (2005). Ubiquilin recruits Eps15 into ibiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. Journal of Cell Science, 118, 4437-4450.

2004

Scholarly publications

Stoorvogel, W., Kerstens, S. M. C., Fritzsche, I., den Hartigh, J. C., van der Heyden, M. A. G., Voortman, J., & van Bergen en Henegouwen, P. M. P. (2004). Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain. Journal of Biological Chemistry, 279(12), 11562-11569.

de Graaf, P., Zwart, W. T., van Dijken, R. A. J., Deneka, M., Schulz, T. K. F., Geijsen, N., Coffer, P. J., Gadella, B. M., Verkleij, A. J., van der Sluijs, P., & van Bergen en Henegouwen, P. M. P. (2004). Phosphatidylinositol 4-kinase beta is critical for functional association of rab11 with the Golgi complex. Molecular Biology of the Cell, 15, 2038-2047.

Other output

Sorokina, I., Klapisz, E. E., Verkleij, A. J., & van Bergen en Henegouwen, P. M. P. (2004). GRK2 interacts with Eps 15 and regulates internalization of EGF receptor. Abstract from FEBS Lecture Course on Signalling & 4th Dubrovnik Signaling Conference, Dubrovnik.

2003

Other output

Ruonala, M. O., van den Heuvel, D. J., Gadella, B. M., Verkleij, A. J., Gerritsen, H. C., & van Bergen en Henegouwen, P. M. P. (2003). The high affinity EGF receptor is present in lipid rafts. Abstract from Unknown event, Asilomar, USA.

2002

Scholarly publications

Klapisz, E. E., Sorokina, I., Lemeer, S., Pijnenburg, M., Verkleij, A. J., & van Bergen en Henegouwen, P. M. P. (2002). A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination. Journal of Biological Chemistry, 277, 30746-30753.

Versteeg, H. H., Sorensen, B. B., Slofstra, S. H., van den Brande, J. H., Stam, J. C., van Bergen en Henegouwen, P. M. P., Richel, D. J., Petersen, L. C., & Peppelenbosch, M. P. (2002). VIIa/tissue factor interaction results in a tissue factor cytoplasmic domin-independent activation of protein synthesis, p70 and p90 S6 kinase phosphorylation. Journal of Biological Chemistry, 277, 27065-27072.

de Graaf, P., Klapisz, E. E., Schulz, T. K. F., Cremers, A. F. M., Verkleij, A. J., & van Bergen en Henegouwen, P. M. P. (2002). Nuclear localization of phosphatidy linositol 4-kinase beta. Journal of Cell Science, 115, 1769-1775.

Other output

van Bergen en Henegouwen, P. M. P. (2002). Phosphatidylinositol 4-kinase-beta binds to and is required for rab11 association with the Golgi complex. Abstract from Euresco Conferences, Tomar, Portugal.

Stam, J. C., Voortman, J., Geerts, W. J. C., de Koning, P., van Dongen, S., Verkleij, A. J., & van Bergen en Henegouwen, P. M. P. (2002). v-Crk enhances cell survival and induces activation of focal adhesion signaling. Abstract from Tumorbiology meeting 2002, Lunteren.

Verkleij, A. J., Ruonala, M. O., Boonstra, J., Humbel, B. M., van den Heuvel, D., Gerritsen, H., & van Bergen en Henegouwen, P. M. P. (2002). EGF signaling through high affinity receptors. 785-786. Abstract from 15th International Congress on Electron Microscopy, Durban, South Africa.

Klapisz, E. E., Sorokina, I., Lemeer, S., Pijnenburg, M., Verkleij, A. J., & van Bergen en Henegouwen, P. M. P. (2002). A Ubiquitin-Interacting Motif (UIM) is essential for Eps15 and Eps15R ubiquitination. Poster session presented at Non-traditional functions of Ubiquitin and ubiquitin-like proteins, Colorado Springs, CO, USA.

2001

Scholarly publications

de Graaf, P., Verkleij, A. J., & van Bergen en Henegouwen, P. M. P. (2001). The role of phosphatidylinositol 4-kinases in vesicular transport. In L. M. G. Heilmeyer, & P. Friedrich (Eds.), Protein modules in cellular signalling (pp. 334-342). IOS Press OHM.

Stam, J. C., Geerts, W. J. C., Versteeg, H. H., Verkleij, A. J., & van Bergen en Henegouwen, P. M. P. (2001). The v-Crk oncogene enhances cell survival and induces activation of protein kinase B/Akt. Journal of Biological Chemistry, 276, 25176-25183.

2000

Scholarly publications

Versteeg, H. H., Hoedemaeker, I., Diks, S. H., Stam, J. C., Spaargaren, M., van Bergen en Henegouwen, P. M. P., van Deventer, S. J. H., & Peppelenbosch, M. P. (2000). Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphoatidylinositol 3-kinase, and Rac. Journal of Biological Chemistry, 275, 28750-28756.

1999

Scholarly publications

Versteeg, H. H., van Bergen en Henegouwen, P. M. P., van Deventer, S. J. H., & Peppelenbosch, M. P. (1999). Cyclooxygenase-dependent signaling: molecular events and consequences. FEBS Letters, 445, 1-5.

Whitehead, B., Tessari, M., Carotenuto, A., van Bergen en Henegouwen, P. M. P., & Vuister, G. W. (1999). The EH1 dmain of Eps15 is structurally classified as a member of the S100 subclass of EF-hand-containing proteins. Biochemistry, 38, 11271-11277.

Doornbos, R. P., Theelen, M., van der Hoeven, P. C. J., Blitterswijk, W. J., Verkleij, A. J., & van Bergen en Henegouwen, P. M. P. (1999). Protein kinase Cdelta is a negative regulator of protein kinase B activity. Journal of Biological Chemistry, 274, 8589-8596.

Carotenuto, A., Tessari, M., Whitehead, B., Aelen, J. M. A., van Bergen en Henegouwen, P. M. P., & Vuister, G. W. (1999). Sequence specific H-1, C-13 and N-15 assignment and secondary structure of the apo EH2 domain of mouse Eps15. Journal of Biomolecular NMR, 14, 97-98.

1998

Scholarly publications

Altun-Gultekin, Z. F., Chandriani, S., Bougeret, C., Ishizaki, T., Narumiya, S., De Graaf, P., Van Bergen En Henegouwen, P., Hanafusa, H., Wagner, J. A., & Birge, R. B. (1998). Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein. Molecular and Cellular Biology, 18(5), 3044-3058. https://doi.org/10.1128/MCB.18.5.3044

Whitehead, B., Tessari, M., Versteeg, H. H., Van Delft, S., Van Bergen En Henegouwen, P. M. P., & Vuister, G. W. (1998). Sequence-specific ¹H, ¹³C and ¹⁵N assignment of the EH1 domain of mouse Eps15. Journal of Biomolecular NMR, 12(3), 465-466. https://doi.org/10.1023/A:1008382305918

1997

Scholarly publications

Van Der Heyden, M. A. G., Nievers, M., Verkleij, A. J., Boonstra, J., & Van Bergen En Henegouwen, P. M. P. (1997). Identification of an intracellular domain of the EGF receptor required for high-affinity binding of EGF. FEBS Letters, 410(2-3), 265-268. https://doi.org/10.1016/S0014-5793(97)00599-1

Van Delft, S., Schumacher, C., Hage, W., Verkleij, A. J., & Van Bergen en Henegouwen, P. M. P. (1997). Association and colocalization of Eps15 with adaptor protein-2 and clathrin. Journal of Cell Biology, 136(4), 811-821. https://doi.org/10.1083/jcb.136.4.811

Nievers, M. G., Birge, R. B., Greulich, H., Verkleij, A. J., Hanafusa, H., & Van Bergen En Henegouwen, P. M. P. (1997). v-Crk-induced cell transformation: Changes in focal adhesion composition and signaling. Journal of Cell Science, 110(3), 389-399.

van der Heijden, M. A. G., Oude Weernink, P. A., van Oirschot - Hermans, B. A., van Bergen en Henegouwen, P. M. P., Boonstra, J., & Rijksen, G. (1997). Epidermal growth factor-induced activation and translocation of pp60 c-src to the cytoskeleton depends on the actin binding domain of the EGF receptor. Biochimica et Biophysica Acta-Molecular Cell Research, 1359, 211-221.

van Delft, S., Govers, R. M. T., Strous, G. J. A. M., Verkleij, A. J., & van Bergen en Henegouwen, P. M. P. (1997). Epidermal growth factor induces ubiquitination op EPs15. Journal of Biological Chemistry, 272, 14013-14016.

Professional publications

van der Heijden, M. A. G., van Bergen en Henegouwen, P. M. P., de Ruiter, N., Verdaasdonk, M. A. M., van den Tweel, J. G., Rijksen, G., Boonstra, J., & Joling, P. (1997). The actin binding domain of the epidermal growth factor-receptor is required for EGF stimulated tissue invasion. Experimental Cell Research, 234, 521-526.

1996

Scholarly publications

Schalkwijk, C. G., Van Der Heijden, M. A. G., Bunt, G., Maas, R., Tertoolen, L. G. J., Van Bergen En Henegouwen, P. M. P., Verkleij, A. J., Van Den Bosch, H., & Boonstra, J. (1996). Maximal epidermal growth-factor-induced cytosolic phospholipase A₂ activation in vivo requires phosphorylation followed by an increased intracellular calcium concentration. Biochemical Journal, 313(1), 91-96. https://doi.org/10.1042/bj3130091

Teng, K. K., Courtney, J. C., Van Bergen En Henegouwen, P., Birge, R. B., & Hempstead, B. L. (1996). Dissociation of NGF induced signal transduction from neurite elongation by expression of a mutant adaptor protein v-Crk in PC12 cells. Molecular and Cellular Neurosciences, 8(2-3), 157-170. https://doi.org/10.1006/mcne.1996.0054

1995

Scholarly publications

van Delft, S., Verkleij, A. J., Boonstra, J., & van Bergen en Henegouwen, P. M. P. (1995). Epidermal growth factor induces serine phosphorylation of actin. FEBS Letters, 357(3), 251-254. https://doi.org/10.1016/0014-5793(94)01359-9

Diakonova, M., Payrastre, B., Van Velzen, A. G., Hage, W. J., Van Bergen en Henegouwen, P. M. P., Boonstra, J., Cremers, F. F. M., & Humbel, B. M. (1995). Epidermal growth factor induces rapid and transient association of phospholipase C-γ1 with EGF-receptor and filamentous actin at membrane ruffles of A431 cells. Journal of Cell Science, 108(6), 2499-2509.

Rijken, P. J., Post, S. M., Hage, W. J., Van Bergen En Henegouwen, P. M. P., Verkleij, A. J., & Boonstra, J. (1995). Actin polymerization localizes to the activated epidermal growth factor receptor in the plasma membrane, independent of the cytosolic free calcium transient. Experimental Cell Research, 218(1), 223-232. https://doi.org/10.1006/excr.1995.1150

1993

Scholarly publications

den Hartigh, J. C., van Bergen en Henegouwen, P. M. P., Boonstra, J., & Verkleij, A. J. (1993). Cholesterol and phosphoinositides increase affinity of the epidermal growth factor receptor. BBA - Biomembranes, 1148(2), 249-256. https://doi.org/10.1016/0005-2736(93)90136-N

1992

Scholarly publications

Ramakers, G. J. A., Verhaagen, J., Oestreicher, A. B., Margolis, F. L., Van Bergen En Henegouwen, P. M. P., & Gispen, W. H. (1992). Immunolocalization of B-50 (GAP-43) in the mouse olfactory bulb: Predominant presence in preterminal axons. Journal of Neurocytology, 21(12), 853-869. https://doi.org/10.1007/BF01191683

van Bergen en Henegouwen, P. M. P., den Hartigh, J. C., Romeyn, P., Verkleij, A. J., & Boonstra, J. (1992). The epidermal growth factor receptor is associated with actin filaments. Experimental Cell Research, 199(1), 90-97. https://doi.org/10.1016/0014-4827(92)90465-K

Raynal, P., van Bergen en Henegouwen, P. M. P., Hullin, F., Ragab-Thomas, J. M. F., Fauvel, J., Verkleij, A., & Chap, H. (1992). Morphological and biochemical evidence for partial nuclear localization of annexin 1 in endothelial cells. Biochemical and Biophysical Research Communications, 186(1), 432-439. https://doi.org/10.1016/S0006-291X(05)80826-5

Payrastre, B., Nievers, M., Boonstra, J., Breton, M., Verkleij, A. J., & Van Bergen en Henegouwen, P. M. P. (1992). A differential location of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix. Journal of Biological Chemistry, 267(8), 5078-5084.

Den Hartigh, J. C., Van Bergen En Henegouwen, P. M. P., Verkleij, A. J., & Boonstra, J. (1992). The EGF receptor is an actin-binding protein. Journal of Cell Biology, 119(2), 349-355. https://doi.org/10.1083/jcb.119.2.349

de Graaf, A., Meijne, A. M. L., van Renswoude, A. J. B. M., Humbel, B. M., van Bergen en Henegouwen, P. M. P., de Jong, L., van Driel, R., & Verkleij, A. J. (1992). Heat shock-induced redistribution of a 160-kDa nuclear matrix protein. Experimental Cell Research, 202(2), 243-251. https://doi.org/10.1016/0014-4827(92)90071-F

Payrastre, B., Van Bergen en Henegouwen, P. M. P., & Chap, H. (1992). UN CYCLE DES PHOSPHOINOSITIDES EXISTE DANS LE NOYAU. Medecine/Sciences, 8(7), 717-719. https://doi.org/10.4267/10608/3209

de Graaf, A., Humbel, B. M., Stuurman, N., van Bergen en Henegouwen, P. M. P., & Verkleij, A. J. (1992). Three-dimensional immunogold labeling of nuclear matrix proteins in permeabilized cells. Cell Biology International Reports, 16(8), 827-836. https://doi.org/10.1016/S0309-1651(05)80025-6

1991

Scholarly publications

De Graaf, A., Van Bergen en Henegouwen, P. M. P., Meijne, A. M. L., Van Driel, R., & Verkleij, A. J. (1991). Ultrastructural localization of nuclear matrix proteins in HeLa cells using silver-enhanced ultra-small gold probes. Journal of Histochemistry and Cytochemistry, 39(8), 1035-1045. https://doi.org/10.1177/39.8.1856453

te Pas, M. F. W., van Bergen en Henegouwen, P. M. P., Boonstra, J., & Ponec, M. (1991). Regulation of epidermal growth factor receptor expression in normal and transformed keratinocytes. Archives of Dermatological Research, 283(2), 125-130. https://doi.org/10.1007/BF00371621

Berkers, J. A. M., Van Bergen en Henegouwen, P. M. P., & Boonstra, J. (1991). Three classes of epidermal growth factor receptors on HeLa cells. Journal of Biological Chemistry, 266(2), 922-927.

Payrastre, B., Van Bergen En Henegouwen, P. M. P., Breton, M., Den Hartigh, J. C., Plantavid, M., Verkleij, A. J., & Boonstra, J. (1991). Phosphoinositide kinase, diacylglycerol kinase, and phospholipase C activities associated to the cytoskeleton: Effect of epidermal growth factor. Journal of Cell Biology, 115(1), 121-128. https://doi.org/10.1083/jcb.115.1.121

Tuijl, M. J. M., van Bergen en Henegouwen, P. M. P., van Wijk, R., & Verkleij, A. J. (1991). The isolated neonatal rat-cardiomyocyte used in an in vitro model for 'ischemia'. II. Induction of the 68 kDa heat shock protein. BBA - Molecular Cell Research, 1091(3), 278-284. https://doi.org/10.1016/0167-4889(91)90190-9

Rijken, P. J., Hage, W. J., Van Bergen En Henegouwen, P. M. P., & Verkleij Boonstra, A. J. J. (1991). Epidermal growth factor induces rapid reorganization of the actin microfilament system in human A431 cells. Journal of Cell Science, 100(3), 491-499.

Boonstra, J., van Bergen en Henegouwen, P. M. P., van Belzen, N., Rijken, P. J., & Verkleij, A. J. (1991). Immunogold labelling in combination with cryoultramicrotomy, freeze‐etching, and label‐fracture. Journal of Microscopy, 161(1), 135-147. https://doi.org/10.1111/j.1365-2818.1991.tb03078.x

1990

Scholarly publications

Riegman, N., Kusters, R., Van Veggel, H., Bergmans, H., Van Bergen en Henegouwen, P., Hacker, J., & Van Die, I. (1990). F1C fimbriae of a uropathogenic Escherichia coli strain: Genetic and functional organization of the foc gene cluster and identification of minor subunits. Journal of Bacteriology, 172(2), 1114-1120. https://doi.org/10.1128/jb.172.2.1114-1120.1990

te Pas, M. F. W., Ponec, M., van Bergen en Henegouwen, P. M. P., Lombardi, P., Havekes, L. M., & Boonstra, J. (1990). Association of EGF and LDL receptors with the cytoskeleton of cultured keratinocytes. Cell Biology International Reports, 14(11), 989-999. https://doi.org/10.1016/0309-1651(90)90111-B

Berkers, J. A. M., van Bergen en Henegouwen, P. M. P., Verkleij, A. J., & Boonstra, J. (1990). Membrane vesicles of A431 cells contain one class of epidermal growth factor binding sites. BBA - Molecular Cell Research, 1052(3), 453-460. https://doi.org/10.1016/0167-4889(90)90155-7

Van Lookeren Campagne, M., Oestreicher, A. B., Van Bergen En Henegouwen, P. M. P., & Gispen, W. H. (1990). Ultrastructural double localization of B-50/GAP43 and synaptophysin (p38) in the neonatal and adult rat hippocampus. Journal of Neurocytology, 19(6), 948-961. https://doi.org/10.1007/BF01186822

1989

Scholarly publications

van Bergen en Henegouwen, P. M. P., Defize, L. H. K., de Kroon, J., van Damme, H., Verkleij, A. J., & Boonstra, J. (1989). Ligand‐induced association of epidermal growth factor receptor to the cytoskeleton of A431 cells. Journal of Cellular Biochemistry, 39(4), 455-465. https://doi.org/10.1002/jcb.240390411

Defize, L. H. K., Boonstra, J., Meisenhelder, J., Kruijer, W., Tertoolen, L. G. J., Tilly, B. C., Hunter, T., Van Bergen en Henegouwen, P. M. P., Moolenaar, W. H., & De Laat, S. W. (1989). Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors. Journal of Cell Biology, 109(5), 2495-2507. https://doi.org/10.1083/jcb.109.5.2495

Van Lookeren Campagne, M., Beate Oestreicher, A., Van Bergen En Henegouwen, P. M. P., & Gispen, W. H. (1989). Ultrastructural immunocytochemical localization of B-50/GAP43, a protein kinase C substrate, in isolated presynaptic nerve terminals and neuronal growth cones. Journal of Neurocytology, 18(4), 479-489. https://doi.org/10.1007/BF01474544

1988

Scholarly publications

Berbers, G. A. M., Kunnen, R., van Bergen en Henegouwen, P. M. P., & Wijk, R. V. (1988). Localization and quantitation of hsp84 in mammalian cells. Experimental Cell Research, 177(2), 257-271. https://doi.org/10.1016/0014-4827(88)90460-0

1987

Scholarly publications

Wiegant, F. A. C., Van Bergen En Henegouwen, P. M. P., Van Dongen, G., & Linnemans, W. A. M. (1987). Stress-induced Thermotolerance of the Cytoskeleton of Mouse Neuroblastoma N2A Cells and Rat Reuber H35 Hepatoma Cells. Cancer Research, 47(6), 1674-1680.

van Bergen en Henegouwen, P. M., Berbers, G., Linnemans, W. A., & van Wijk, R. (1987). Subcellular localization of the 84,000 dalton heat-shock protein in mouse neuroblastoma cells: evidence for a cytoplasmic and nuclear location. European Journal of Cell Biology, 43(3), 469-478.

van Bergen en Henegouwen, P. M. P., & Linnemans, W. A. M. (1987). Heat shock gene expression and cytoskeletal alterations in mouse neuroblastoma cells. Experimental Cell Research, 171(2), 367-375. https://doi.org/10.1016/0014-4827(87)90169-8

1986

Scholarly publications

van Bergen en Henegouwen, P. M. P., & Leunissen, J. L. M. (1986). Controlled growth of colloidal gold particles and implications for labelling efficiency. Histochemistry, 85(1), 81-87. https://doi.org/10.1007/BF00508657

Roosendaal, B., Van Bergen En Henegouwen, P. M. P., & De Graaf, F. K. (1986). Subcellular localization of K99 fimbrial subunits and effect of temperature on subunit synthesis and assembly. Journal of Bacteriology, 165(3), 1029-1032. https://doi.org/10.1128/jb.165.3.1029-1032.1986

1985

Scholarly publications

Van Bergen En Henegouwen, P. M. P., Jordi, W. J. R. M., Dongen, G. V., Ramaekers, F. C. S., Amesz, H., & Linnemans, W. A. M. (1985). Studies on a possible relationship between alterations in the cytoskeleton and induction of heat shock protein synthesis in mammalian cells. International Journal of Hyperthermia, 1(1), 69-83. https://doi.org/10.3109/02656738509029275

See publications on the UU Research Portal