EDUCATION:
1959-1966 Gymnasium ß; Jansenius Lyceum, Hulst, The Netherlands
1966-1974 Undergraduate study; Catholic University, Nijmegen, The Netherlands. Degree: Biochemistry (major subject: biochemistry; minor subjects: physiology, pharmacochemistry, and clinical biochemistry)
1974-1979 Graduate study; Agricultural University, Wageningen, The Netherlands. Degree: Ph.D., March 1980. Thesis: "Viral Protein Synthesis in Cowpea Mosaic Virus Infected Protoplasts" (Advisor/Promotor: Prof.Dr. A. van Kammen).
EMPLOYMENT HISTORY:
1979-1985 Research Associate in the Department of Virology (Chairman Prof.Dr. M.C.Horzinek), Veterinary Faculty, Utrecht University, The Netherlands. Within the Molecular Virology division (group leader Dr. B.A.M. van der Zeijst) studies on the synthesis, membrane integration, transport and maturation of coronaviral membrane glycoproteins.
1982 Short-term EMBO-fellow at the European Molecular Biology Laboratory (EMBL) in Heidelberg (FRG) to study the nucleotide sequence of the nucleocapsid and E1 genes of mouse hepatitis coronavirus and the assembly of the E1 protein in membranes (collaboration with Dr. J. Armstrong and Dr. G. Warren).
1984 Short-term EMBO-fellow at the EMBL in Heidelberg (FRG) to study the involvement of Signal Recognition Particle in membrane integration of the coronaviral E1 glycoprotein (collaboration with Dr. J. Armstrong and Dr. D.I. Meyer).
1985-1986 Research Associate at the Salk Institute (Dr. J.K. Rose; Molecular Biology & Virology Laboratory), San Diego, California. Main research subject: biogenesis of the vesicular stomatitis virus G protein in vitro and in vivo.
1986-1987 Research Associate at Yale University, School of Medicine (Dept. of Pathology, Prof.Dr. J.K. Rose), New Haven, Connecticut. Research subjects: i) biogenesis of the vesicular stomatitis virus G protein in vivo and in vitro and ii) expression and mutagenesis of the coronaviral E1 glycoprotein.
1987-1990 Research Scientist in the Institute of Virology (Head Prof.Dr. M.C. Horzinek), Veterinary Faculty, Utrecht University, The Netherlands. Working within the Molecular Virology division (group leader Dr. W.J.M. Spaan) on the biogenesis and intracellular transport of viral membrane proteins.
1990-1995 Associate Professor in the Institute of Virology, Veterinary Faculty, Dept.Infectious Diseases & Immunology, Utrecht University, The Netherlands. Lines of research:
i) assembly of enveloped viruses
ii) molecular pathogenesis of viral infections
iii) development of animal virus vaccines.
1995-2012 Professor in Virology & Virus Diseases; head of the Division of Virology, Department of Infectious Diseases & Immunology, Veterinary Faculty, Utrecht University, The Netherlands. Lines of research as before.
1999-2003 Chairman of the Department of Infectious Diseases & Immunology, Veterinary Faculty, Utrecht University.
2001-2002 Sabbatical year, spent at The Scripps Research Institute in La Jolla, California (host: Prof.Dr.J.Johnson)
2003-2005 Director of the Institute of Veterinary Sciences and of the Graduate School for Animal Health, both at the Veterinary Faculty of Utrecht University
2012-2016 Professor in Veterinary Virology in the Division of Virology, Department of Infectious Diseases & Immunology, Veterinary Faculty, Utrecht University, The Netherlands (head: prof. dr. Frank van Kuppeveld). Lines of research as before.
2016-2019 Visiting Professor and research advisor in animal virology at the Shanghai Academy of Agricultural Sciences, Shanghai, People’s Republic of China (appointment 2 months/year).
2016-present Emeritus professor and advisor in the Division of Virology (head: prof. dr. Frank van Kuppeveld), Department of Biomolecular Health Sciences, Veterinary Faculty, Utrecht University.
2019 Temporary advisor on Covid-19 related issues; Veterinary Faculty, Utrecht university, The Netherlands.