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Prof. dr. M.R. (Maarten) Egmond

Emeritus Professor 
Science
Chemistry
Chemistry
Hugo R. Kruytgebouw
Padualaan 8
Kamer Z811
3584 CH Utrecht

Prof. dr. M.R. (Maarten) Egmond

Emeritus Professor
Chemistry
+31 30 253 3526
m.r.egmond@uu.nl
Profile Publications Ancillary activities Contact
Profile Publications Ancillary activities Contact

Publications

2019

Scholarly publications

Domínguez Pardo, J. J., van Walree, C. A., Egmond, M. R., Koorengevel, M. C., & Killian, J. A. (2019). Nanodiscs bounded by styrene-maleic acid allow trans-cis isomerization of enclosed photoswitches of azobenzene labeled lipids. Chemistry and Physics of Lipids, 220, 1-5. https://doi.org/10.1016/j.chemphyslip.2019.02.002
Van Willigen, M., Vonk, A. M., Yeoh, H. Y., Kruisselbrink, E., Kleizen, B., Van Der Ent, C. K., Egmond, M. R., De Jonge, H. R., Braakman, I., Beekman, J. M., & Van Der Sluijs, P. (2019). Folding-function relationship of the most common cystic fibrosis-causing CFTR conductance mutants. Life Science Alliance, 2(1), [e201800172]. https://doi.org/10.26508/lsa.201800172
Schildknegt, D., Lodder, N., Pandey, A., Egmond, M., Pena, F., Braakman, I., & van der Sluijs, P. (2019). Characterization of CNPY5 and its family members. Protein Science, 28(7), 1276-1289. https://doi.org/10.1002/pro.3635

2018

Scholarly publications

Liu, Y., Moura, E. C. C. M., Dörr, J. M., Scheidelaar, S., Heger, M., Egmond, M. R., Killian, J. A., Mohammadi, T., & Breukink, E. (2018). Correction: Bacillus subtilis MraY in detergent-free system of nanodiscs wrapped by styrene-maleic acid copolymers. PLoS One, 13(12), e0210135. https://doi.org/10.1371/journal.pone.0210135
Liu, Y., Moura, E. C. C. M., Dörr, J. M., Scheidelaar, S., Heger, M., Egmond, M. R., Killian, J. A., Mohammadi, T., & Breukink, E. (2018). Bacillus subtilis MraY in detergent-free system of nanodiscs wrapped by styrene-maleic acid copolymers. PLoS One, 13(11), [e0206692]. https://doi.org/10.1371/journal.pone.0206692

2017

Scholarly publications

Reiniers, M. J., van Golen, R. F., Bonnet, S., Broekgaarden, M., van Gulik, T. M., Egmond, M. R., & Heger, M. (2017). Preparation and Practical Applications of 2',7'-Dichlorodihydrofluorescein in Redox Assays. Analytical Chemistry, 89(7), 3853-3857. https://doi.org/10.1021/acs.analchem.7b00043
Broekgaarden, M., Weijer, R., van Wijk, A. C., Cox, R. C., Egmond, M. R., Hoebe, R., van Gulik, T. M., & Heger, M. (2017). Photodynamic Therapy with Liposomal Zinc Phthalocyanine and Tirapazamine Increases Tumor Cell Death via DNA Damage. Journal of Biomedical Nanotechnology, 13(2), 204-220. https://doi.org/10.1166/jbn.2017.2327

2016

Scholarly publications

Liu, Y., Garcia Lopes Maia Rodrigues, J., Bonvin, A. M. J. J., Zaal, E. A., Berkers, C. R., Heger, M., Gawarecka, K., Swiezewska, E., Breukink, E., & Egmond, M. R. (2016). New insight into the catalytic mechanism of bacterial mray from enzyme kinetics and docking studies. Journal of Biological Chemistry, 291(29), 15057-15068. https://doi.org/10.1074/jbc.M116.717884

2015

Scholarly publications

Furse, S., Egmond, M. R., & Killian, J. A. (2015). Isolation of lipids from biological samples. Molecular Membrane Biology, 32(3), 55-64. https://doi.org/10.3109/09687688.2015.1050468
Spelbrink, R. E. J., Lensing, H., Egmond, M. R., & Giuseppin, M. L. F. (2015). Potato Patatin Generates Short-Chain Fatty Acids from Milk Fat that Contribute to Flavour Development in Cheese Ripening. Applied Biochemistry and Biotechnology, 176(1), 231-43. https://doi.org/10.1007/s12010-015-1569-3

2013

Scholarly publications

Teixeira, A., Cox, R. C., & Egmond, M. R. (2013). Furan fatty acids efficiently rescue brain cells from cell death induced by oxidative stress. Food & function, 4(8), 1209-1215. https://doi.org/10.1039/C3FO60094G

2012

Scholarly publications

Wieczorek, B., Snelders, D. J. M., Dijkstra, H. P., Versluis, C., Lutz, M., Spek, A. L., Egmond, M. R., Klein Gebbink, R. J. M., & van Koten, G. (2012). Coordination Chemistry in Water of a Free and a Lipase-Embedded Cationic NCN-Pincer Platinum Center with Neutral and Ionic Triarylphosphines. Organometallics, 31, 2810-2820. https://doi.org/10.1021/om2010832

2011

Scholarly publications

Wieczorek, B., Träff, A., Krumlinde, P., Dijkstra, H. P., Egmond, M. R., van Koten, G., Bäckvall, J-E., & Klein Gebbink, R. J. M. (2011). Covalent anchoring of a racemization catalyst to CALB-beads: towards dual immobilization of DKR catalysts. Tetrahedron Letters, 52(14), 1601-1604. https://doi.org/10.1016/j.tetlet.2011.01.106
van der Poel, S., Wolthoorn, J., van den Heuvel, D., Egmond, M. R., Groux-Degroote, S., Neumann, S., Gerritsen, H. C., van Meer, G., & Sprong, H. (2011). Hyperacidification of trans-Golgi network and endo/lysosomes in melanocytes by glucosylceramide-dependent V-ATPase activity. Traffic, 12(11), 1634-1647. https://doi.org/10.1111/j.1600-0854.2011.01263.x

2010

Scholarly publications

van Kampen, M. D., Rosenstein, R., Götz, F., & Egmond, M. R. (2010). Cloning, purification and characterisation of Staphylococcus warneri lipase 2. Biochimica Et Biophysica Acta. Protein Structure And Molecular Enzymology, 1544(1-2), 229-241. https://doi.org/10.1016/S0167-4838(00)00224-7
Wieczorek, B., Lemcke, B., Dijkstra, H. P., Egmond, M. R., Klein Gebbink, R. J. M., & van Koten, G. (2010). Site-selective ser-hydrolase labelling with a luminescent organometallic NCN-platinum complex. European Journal of Inorganic Chemistry, 13, 1929-1938. https://doi.org/10.1002/ejic.200900980
Snijder, H. J., Kingma, R. L., Kalk, K. H., Dekker, N., Egmond, M. R., & Dijkstra, B. W. (2010). Structural investigations of calcium binding and its role in activity and activation of outer membrane phospholipase A from Escherichia coli. Journal of Molecular Biology, 309(2), 477-489. https://doi.org/10.1006/jmbi.2001.4675
Rodenbrock, A., Selber, K., Egmond, M. R., & Kula, M-R. (2010). Extraction of peptide tagged cutinase in detergent-based aqueous two-phase systems. Bioseparation, 9(5), 269-276. https://doi.org/10.1023/A:1011190713820
Kramer, R. A., Zandwijken, D., Cox, R. C., Egmond, M. R., & Dekker, N. (2010). Fluorescent substrates for the endoprotease OmpT. In R. Epton (Ed.), Innovation and perspectives in solid phase synthesis & combinatorial libraries 2000 : peptides, proteins and nucleic acids : small molecule organic chemical diversity : collected papers, Sixth International Symposium, York, England, UK (pp. 301-304). Mayflower Wordwide.
Grönroos, J. O., Laine, V. J. O., Janssen, M. J. W., Egmond, M. R., & Nevalainen, T. J. (2010). Bactericidal properties of group IIA and group V phospholipases A2. Journal of Immunology, 166, 4029-4034. https://doi.org/10.4049/jimmunol.166.6.4029

2009

Scholarly publications

Rutten, L., Wieczorek, B., Mannie, J-PBA., Kruithof, C. A., Dijkstra, H. P., Egmond, M. R., Lutz, M., Klein Gebbink, R. J. M., Gros, P., & van Koten, G. (2009). Solid-state structural characterization of cutinase-ECE-pincer-metal hybrids. Chemistry-A European Journal, 15(17), 4270-4280.
Wieczorek, B., Dijkstra, H. P., Egmond, M. R., Klein Gebbink, R. J. M., & van Koten, G. (2009). Incorporating ECE-pincer metal complexes as functional building blocks in semisynthetic metalloenzymes, supramolecular polypeptide hybrids, tamoxifen derivatives, biomarkers and sensors. Journal of Organometallic Chemistry, 694(6), 812-822. http://www.elsevier.com
Rutten, L., Mannie, J-PBA., Stead, C. M., Raetz, C. R. H., Reynolds, C. M., Bonvin, A. M. J. J., Tommassen, J. P. M., Egmond, M. R., Trent, M. S., & Gros, P. (2009). Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium. Proceedings of the National Academy of Sciences of the United States of America, 106(6), 1960-1964. https://doi.org/10.1073/pnas.0813064106
https://dspace.library.uu.nl/bitstream/handle/1874/42725/1960.full.pdf?sequence=1
Tsaytler, P. A., Krijgsveld, J., Goerdayal, S. S., Rüdiger, S., & Egmond, M. R. (2009). Novel Hsp90 partners discovered using complementary proteomic approaches. Cell Stress & Chaperones, (14), 629-638.

2008

Scholarly publications

Kruithof, C. A., Dijkstra, H. P., Lutz, M., Spek, A. L., Egmond, M. R., Klein Gebbink, R. J. M., & van Koten, G. (2008). Non-tethered organometallic phosphonate inhibitors for lipase inhibition: positioning of the metal center in the active site of cutinase. European Journal of Inorganic Chemistry, 2008(28), 4425-4432.
https://dspace.library.uu.nl/bitstream/handle/1874/33216/790.pdf?sequence=1
Tsaytler, P. A., O'Flaherty, M. C., Sakharov, D. V., Krijgsveld, J., & Egmond, M. R. (2008). Immediate protein targets of photodynamic treatment in carcinoma cells. Journal of Proteome Research, 7(9), 3868-3878.
https://dspace.library.uu.nl/bitstream/handle/1874/32610/14.%2520Tsaytler%25202008%2520pp%25203868-78.pdf?sequence=1
Neumann, S., Opacic, M., Wechselberger, R. W., Sprong, H., & Egmond, M. R. (2008). Glycolipid transfer protein: clear structure and activity, but enigmatic function. Advances in Enzyme Regulation, 48(1), 137-151.
https://dspace.library.uu.nl/bitstream/handle/1874/33242/534.pdf?sequence=1

2007

Scholarly publications

Dijkstra, H. P., Sprong, H., Aerts, B. N. H., Kruithof, C. A., Egmond, M. R., & Klein Gebbink, R. J. M. (2007). Selective and diagnostic labelling of serine hydrolases with reactive phosphonate inhibitors. Organic & Biomolecular Chemistry, 6, 523-531.
van Zoelen, D. J., Egmond, M. R., Pieters, R. J., & Liskamp, R. M. J. (2007). Synthesis and evaluation of TAC-based inhibitors of papain as mimics of cystatin B. ChemBioChem, 8, 1950-1956.
https://dspace.library.uu.nl/bitstream/handle/1874/26400/vanZoelen%25202007%2520pp%25201950-56.pdf?sequence=2

2006

Scholarly publications

van Meer, G., Egmond, M. R., & Halter, D. (2006). Sphingolipids and multidrug resistance of cancer cells. In Y. Hirabayashi, Y. Igarashi, & A. H. Merrill jr. (Eds.), Sphingolipid Biology (pp. 263-270). Springer.
van Meer, G., Halter, D., Sprong, H., Somerharju, P., & Egmond, M. R. (2006). ABC lipid transporters: extruders, flippases, or flopless activators? FEBS Letters, 580, 1171-1177.
https://dspace.library.uu.nl/bitstream/handle/1874/19996/15.%2520van%2520Meer%25202006%2520pp1171-77.pdf?sequence=1
Wierenga, P. A., Kosters, H., Egmond, M. R., Voragen, A. G. J., & Jongh, H. H. J. (2006). Importance of physical vs. chemical interactions in surface shear rheology. Advances in Colloid and Interface Science, 119, 131-139.
https://dspace.library.uu.nl/bitstream/handle/1874/19998/17.Wierenga%25202006%2520pp%2520131-39.pdf?sequence=1
Wierenga, P. A., Egmond, M. R., Voragen, A. G. J., & de Jongh, H. H. J. (2006). The adsorption and unfolding kinetics determines the folding state of proteins at the air-water interface and thereby the equation of state. Journal of Colloid and Interface Science, 299, 850-857.
https://dspace.library.uu.nl/bitstream/handle/1874/19997/16.Wierenga%25202006%2520pp%2520850-57.pdf?sequence=1
Rutten, L., Geurtsen, J. J. G., Lambert, W., Smolenaers, J. J. M., Bonvin, A. M., de Haan, A., van der Ley, P., Egmond, M. R., Gros, P., & Tommassen, J. P. M. (2006). Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America, 103, 7071-7076. https://doi.org/10.1073/pnas.0509392103

2005

Scholarly publications

Kruithof, C. A., Casado Lacabra, M. A., Guillena, G., Egmond, M. R., van der Kerk-van Hoof, A. C., Heck, A. J. R., Klein Gebbink, R. J. M., & van Koten, G. (2005). Lipase Active-Site-Directed Anchoring of Organometallics:Metallopincer/Protein Hybrids. Chemistry-A European Journal, 11, 6869-6877.
Brandenburg, K., Garidel, P., Schromm, A. B., Andra, J., Egmond, M., & Wiese, A. (2005). Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT:lipopolysaccharide complexes. European biophysics journal, 34, 28-41.
https://dspace.library.uu.nl/bitstream/handle/1874/7920/2.Brandenburg%25202005%2520pp28-41.pdf?sequence=2
Wierenga, P. A., Meinders, M. J. B., Egmond, M. R., Voragen, A. G. J., & de Jongh, H. H. J. (2005). Quantitative description of the relation between protein net charge and protein adsorption to air-water interfaces. Journal of Physical Chemistry. B, 109, 16946-16952.
https://dspace.library.uu.nl/bitstream/handle/1874/14759/12.Wierenga%25202005%2520pp%252016946-16952.pdf?sequence=1

2004

Scholarly publications

Snoek, G. T., van Tiel, C. M., & Egmond, M. R. (2004). Structure-function relationships of phosphatidylinositol transfer proteins: involvement of phosphorylation sites. Biochimie, 86(11), 857-864.
https://dspace.library.uu.nl/bitstream/handle/1874/14607/12.Snoek2004%2C%2520pp857-64.pdf?sequence=1

2003

Scholarly publications

Guillena Townley, G., Kruithof, C. A., Casado Lacabra, M. A., Egmond, M. R., & van Koten, G. (2003). The Suzuki cross-coupling reaction: a powerful tool for the attachment of organometallic 'NCN'-pincer units to biological scaffolds. Journal of Organometallic Chemistry, 668, 3-7.
https://dspace.library.uu.nl/bitstream/handle/1874/14486/14.Guillena%25202003%2520pp3-7.pdf?sequence=1
Nieuwenhuizen, W. F., van Leeuwen, S., Jack, R. W., Egmond, M. R., & Götz, F. (2003). Molecular cloning and characterization of the alkaline ceramidase from Pseudomonas aeruginosa PA01. Tijdschrift: tijdelijk onbekend, 30, 94-104.
https://dspace.library.uu.nl/bitstream/handle/1874/14379/5.Nieuwenhuzen2003%2520pp94-104.pdf?sequence=1
Wierenga, P. A., Meinders, M. B., Egmond, M. R., Voragen, A. G. J., & de Jongh, H. H. J. (2003). Protein exposed hydrophobicity reduces the kinetic barrier of adsorption of ovalbumin to the air-water interface. Langmuir, 19, 8964-8970.
https://dspace.library.uu.nl/bitstream/handle/1874/14948/12.Wierenga2003%2520pp8964-70.pdf?sequence=1

Other output

Nieuwenhuizen, W. F., Egmond, M. R., van der Wilden, W., & Oudenaarde, I. (2003). Use of a sphingoid base for inhibiting ceramidase activity. (Patent No. EP 1287815 A1 200303).

2002

Scholarly publications

Nilsson, A., Mannesse, M. L. M., Egmond, M. R., & Tjerneld, F. (2002). Cutinase-peptide fusions in thermoseparating aqueus two-phase systems : Prediciton of partitioning and enhanced tag efficiency by detergent addition. Journal of Chromatography A, 946, 141-155.
https://dspace.library.uu.nl/bitstream/handle/1874/14273/12Nilsson2002%2520pp141-55.pdf?sequence=1
Kingma, R. L., & Egmond, M. R. (2002). Substrate interferes with dimerisation of outer membrane phopsholipase A. FEBS Letters, 516, 31-34.
https://dspace.library.uu.nl/bitstream/handle/1874/14269/5.Kingma2002%2520pp31-34.pdf?sequence=1
Nilsson, A., Johansson, H-O., Mannesse, M., Egmond, M. R., & Tjerneld, F. (2002). Partitioning of peptide-tagged proteins in aqueous two-phase systems using hydrophobically modified micelle-forming thermoseparating polymer. Biochimica et Biophysica Acta, 1601, 138-148.
Kingma, R. L., & Egmond, M. R. (2002). Activation of a covalent outer membrane phospholipase A dimer. European Journal of Biochemistry, 269, 2178-2185.
https://dspace.library.uu.nl/bitstream/handle/1874/14268/4.Kingma%25202002%2520pp%25202178-85.pdf?sequence=1
Kramer, R. A., Brandenburg, K., Vandeputte-Rutten, L., Werkhoven, M., Gros, P., Dekker, N., & Egmond, M. R. (2002). Lipopolysaccharide regions involved in the activation of Escherichia coli outer membrane protease OmpT. European Journal of Biochemistry, 269, 1746-1752.
https://dspace.library.uu.nl/bitstream/handle/1874/14272/9.Kramer2002%2520pp1746-52.pdf?sequence=1
Calado, C. R. C., Mannesse, M. L. M., Egmond, M. R., Cabral, J. M. S., & Fonseca, L. P. (2002). Production of wild-type and peptide fusion cutinases by recombinant Saccharomyces cerevisiae MM01 strains. Tijdschrift: tijdelijk onbekend, 78(6), 692-698.
https://dspace.library.uu.nl/bitstream/handle/1874/14270/2.Calado%25202002pp%2520692-8.pdf?sequence=1
Kooter, I. M., Steiner, R. A., Dijkstra, B. W., Noort, P. I., & Egmond, M. R. (2002). EPR characterisation of the mononuclear Cu-containing Aspergillus japonicus quercetin 2,3-dioxygenase reveals dramatic changes upon anaerobic binding of substrates. European Journal of Biochemistry, 269, 2971-2979.
https://dspace.library.uu.nl/bitstream/handle/1874/26003/8.Kooter%25202002%2520pp%25202971-9.pdf?sequence=1
Nieuwenhuizen, W. F., van Leeuwen, S., Götz, F., & Egmond, M. R. (2002). Synthesis of a novel fluorescent ceramide analogue and its use in the characterization of recombinant ceramidase from Pseudomonas aeruinosa Pa01. Chemistry and Physics of Lipids, 114, 181-191.
https://dspace.library.uu.nl/bitstream/handle/1874/14267/10.Nieuwenhuizen2002%2520pp181-91.pdf?sequence=1
Kingma, R. L., Snijder, H. J., Dijkstra, B. W., Dekker, N., & Egmond, M. R. (2002). Functional importance of calcium binding sites in outer membrane phospholipase A. Biochimica et Biophysica Acta, 1561, 230-237.
https://dspace.library.uu.nl/bitstream/handle/1874/14271/6.Kingma2002%2520pp230-37.pdf?sequence=1

Professional publications

Fusetti, F., Schröter, K. H., Steiner, R. A., Noort, P. I., Pijning, T., Rozeboom, H. J., Kalk, K. H., Egmond, M. R., & Dijkstra, B. W. (2002). Crystal structure of the copper-containing quercetin 2,3-dioxygenase from Aspergillus japonicus. Structure, 10, 259-268.
https://dspace.library.uu.nl/bitstream/handle/1874/14262/3.Fusetti2002%2520pp259-68.pdf?sequence=1

2001

Scholarly publications

Snijder, H. J., van Eerde, J. H., Kalk, K. H., Dekker, N., Egmond, M. R., & Dijkstra, B. W. (2001). Structural investigations of the active-site mutant Asn156Ala of outer membrane phospholipase A: Function of the Asn-His interaction in the catalytic triad. Protein Science, 10(10), 1962-1969. https://doi.org/10.1110/ps.17701
Vandeputte-Rutten, L., Kramer, R. A., Kroon, J., Dekker, N., Egmond, M. R., & Gros, P. (2001). Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site EMBO Journal. EMBO Journal, 20, 5033-5039.
Kramer, R. A., Vandeputte-Rutten, L., de Roon, G. J., Gros, P., Dekker, N., & Egmond, M. R. (2001). Identification of essential acidic residues of outer membrane protease OmpT supports a novel active site. FEBS Letters, 505, 426-430.
Hirschberg, J. H. B. H., Simons, J. F. A., Dekker, N., & Egmond, M. R. (2001). Cloning, expression, purification and characterization of patatin, a novel phospholipase A. European Journal of Biochemistry, 268, 5037-5044.
Dekker, N., Cox, R. C., Kramer, R. A., & Egmond, M. R. (2001). Substrate specificity of the integral membrane protease OmpT determined by spatially addressed peptide libraries. Biochemistry, 40(6), 1694-1701. https://doi.org/10.1021/bi0014195

1973

Scholarly publications

Egmond, M. R., Veldink, G. A., Vliegenthart, J. F. G., & Boldingh, J. (1973). C 11 H abstraction from linoleic acid, the rate limiting step in lipoxygenase catalysis. Biochemical and Biophysical Research Communications, 54(3), 1178-1184. https://doi.org/10.1016/0006-291X(73)90816-4

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