Dr. M.P. (Marc) Baggelaar

Assistant Professor
Biomol.Mass Spectrometry & Proteom.

Publications

2023

Scholarly publications

Kaiyrzhanov, R., Rad, A., Lin, S-J., Bertoli-Avella, A., Kallemeijn, W. W., Godwin, A., Zaki, M. S., Huang, K., Lau, T., Petree, C., Efthymiou, S., Ghayoor Karimiani, E., Hempel, M., Normand, E. A., Rudnik-Schöneborn, S., Schatz, U. A., Baggelaar, M. P., Ilyas, M., Sultan, T., ... Maroofian, R. (2023). Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. Brain. Advance online publication. https://doi.org/10.1093/brain/awad380
van Bergen, W., Fiala, J., Heck, AJ., & Baggelaar, M. (2023). Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs. bioRxiv, Article 562725. https://www.biorxiv.org/content/10.1101/2023.10.19.562725v1.full.pdf
Ocasio, C. A., Baggelaar, M., Sipthorp, J., Losada de la Lastra, A., Volarić, J., Soudy, C., Storck, E. M., Palma-Duran, S. A., MacRae, J. I., Tomic, G., Carr, L., Downward, J., S. Eggert, U., & Tate, E. W. (2023). A palmitoyl transferase chemical genetic system to map ZDHHC-specific S-acylation. bioRxiv, Article 537386. https://www.biorxiv.org/content/10.1101/2023.04.18.537386v1.full.pdf
Tomic, G., Refermat, A. Y., Sheridan, C., Baggelaar, M., Sipthorp, J., Sudarshan, B., Ocasio, C. A., Suárez-Bonnet, A., Priestnall , S. L., Herbert, E., Tate, E. W., & Downward, J. (2023). Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis. bioRxiv, Article 527637. https://www.biorxiv.org/content/10.1101/2023.02.08.527637v2.full.pdf
Baggelaar, M., Sardana, S., & Nederstigt, R. (2023). S‑Palmitoylation during Retinoic Acid-Induced Neuronal Differentiation of SH-SY5Y Neuroblastoma Cells. Journal of Proteome Research, 2421–2435. https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00151
van Bergen, W., Hevler, J. F., Wu, W., Baggelaar, M. P., & Heck, A. J. R. (2023). Site-specific Activity-based Protein Profiling Using Phosphonate Handles. Molecular and Cellular Proteomics, 22(1), 1-15. Article 100455. https://doi.org/10.1016/j.mcpro.2022.100455

2022

Scholarly publications

van Bergen, W., Heck, A. J. R., & Baggelaar, M. P. (2022). Recent advancements in mass spectrometry-based tools to investigate newly synthesized proteins. Current Opinion in Chemical Biology, 66, Article 102074. https://doi.org/10.1016/j.cbpa.2021.07.001

2019

Scholarly publications

Zhou, J., Mock, E. D., Martella, A., Kantae, V., Di, X., Burggraaff, L., Baggelaar, M. P., Al-Ayed, K., Bakker, A., Florea, B. I., Grimm, S. H., den Dulk, H., Li, C. T., Mulder, L., Overkleeft, H. S., Hankemeier, T., van Westen, G. J. P., & van der Stelt, M. (2019). Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI. ACS Chemical Biology, 14(2), 164-169. https://doi.org/10.1021/acschembio.8b00969
Baggelaar, M. P., den Dulk, H., Florea, B. I., Fazio, D., Perruzza, D., Bernabò, N., Raspa, M., Janssen, A. P. A., Scavizzi, F., Barboni, B., Overkleeft, H. S., Maccarrone, M., & van der Stelt, M. (2019). ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction. ACS Chemical Biology, 14(12), 2943. https://doi.org/10.1021/acschembio.9b00824

2018

Scholarly publications

van Rooden, E. J., Florea, B. I., Deng, H., Baggelaar, M. P., van Esbroeck, A. C. M., Zhou, J., Overkleeft, H. S., & van der Stelt, M. (2018). Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification. Nature protocols, 13(4), 752-767. https://doi.org/10.1038/nprot.2017.159
Baggelaar, M. P., Maccarrone, M., & van der Stelt, M. (2018). 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain. Progress in Lipid Research, 71, 1-17. https://doi.org/10.1016/j.plipres.2018.05.002
van Rooden, E. J., van Esbroeck, A. C. M., Baggelaar, M. P., Deng, H., Florea, B. I., Marques, A. R. A., Ottenhoff, R., Boot, R. G., Overkleeft, H. S., Aerts, J. M. F. G., & van der Stelt, M. (2018). Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain. Frontiers in Neuroscience, 12, 440. https://doi.org/10.3389/fnins.2018.00440

2017

Scholarly publications

Deng, H., van der Wel, T., van den Berg, R. J. B. H. N., van den Nieuwendijk, A. M. C. H., Janssen, F. J., Baggelaar, M. P., Overkleeft, H. S., & van der Stelt, M. (2017). Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors. MedChemComm, 8(5), 982-988. https://doi.org/10.1039/c7md00029d
Deng, H., Kooijman, S., van den Nieuwendijk, A. M. C. H., Ogasawara, D., van der Wel, T., van Dalen, F., Baggelaar, M. P., Janssen, F. J., van den Berg, R. J. B. H. N., den Dulk, H., Cravatt, B. F., Overkleeft, H. S., Rensen, P. C. N., & van der Stelt, M. (2017). Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. Journal of Medicinal Chemistry, 60(1), 428-440. https://doi.org/10.1021/acs.jmedchem.6b01482
Baggelaar, M. P., & Van der Stelt, M. (2017). Competitive ABPP of Serine Hydrolases: A Case Study on DAGL-Alpha. Methods in Molecular Biology, 1491, 161-169. https://doi.org/10.1007/978-1-4939-6439-0_12
Soethoudt, M., Grether, U., Fingerle, J., Grim, T. W., Fezza, F., de Petrocellis, L., Ullmer, C., Rothenhäusler, B., Perret, C., van Gils, N., Finlay, D., MacDonald, C., Chicca, A., Gens, M. D., Stuart, J., de Vries, H., Mastrangelo, N., Xia, L., Alachouzos, G., ... van der Stelt, M. (2017). Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity. Nature Communications, 8, 13958. https://doi.org/10.1038/ncomms13958
Baggelaar, M. P., van Esbroeck, A. C. M., van Rooden, E. J., Florea, B. I., Overkleeft, H. S., Marsicano, G., Chaouloff, F., & van der Stelt, M. (2017). Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases. ACS Chemical Biology, 12(3), 852-861. https://doi.org/10.1021/acschembio.6b01052
van Esbroeck, A. C. M., Janssen, A. P. A., Cognetta, A. B., Ogasawara, D., Shpak, G., van der Kroeg, M., Kantae, V., Baggelaar, M. P., de Vrij, F. M. S., Deng, H., Allarà, M., Fezza, F., Lin, Z., van der Wel, T., Soethoudt, M., Mock, E. D., den Dulk, H., Baak, I. L., Florea, B. I., ... van der Stelt, M. (2017). Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474. Science (New York, N.Y.), 356(6342), 1084-1087. https://doi.org/10.1126/science.aaf7497
Petracca, R., Romeo, E., Baggelaar, M. P., Artola, M., Pontis, S., Ponzano, S., Overkleeft, H. S., van der Stelt, M., & Piomelli, D. (2017). Novel activity-based probes for N-acylethanolamine acid amidase. Chemical communications (Cambridge, England), 53(86), 11810-11813. https://doi.org/10.1039/c7cc06838g

2016

Scholarly publications

Mukhopadhyay, P., Baggelaar, M., Erdelyi, K., Cao, Z., Cinar, R., Fezza, F., Ignatowska-Janlowska, B., Wilkerson, J., van Gils, N., Hansen, T., Ruben, M., Soethoudt, M., Heitman, L., Kunos, G., Maccarrone, M., Lichtman, A., Pacher, P., & Van der Stelt, M. (2016). The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity. British Journal of Pharmacology, 173(3), 446-58. https://doi.org/10.1111/bph.13338
Ogasawara, D., Deng, H., Viader, A., Baggelaar, M. P., Breman, A., den Dulk, H., van den Nieuwendijk, A. M. C. H., Soethoudt, M., van der Wel, T., Zhou, J., Overkleeft, H. S., Sanchez-Alavez, M., Mori, S., Nguyen, W., Conti, B., Liu, X., Chen, Y., Liu, Q-S., Cravatt, B. F., & van der Stelt, M. (2016). Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Proceedings of the National Academy of Sciences of the United States of America, 113(1), 26-33. https://doi.org/10.1073/pnas.1522364112

2015

Scholarly publications

van der Wel, T., Janssen, F. J., Baggelaar, M. P., Deng, H., den Dulk, H., Overkleeft, H. S., & van der Stelt, M. (2015). A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α. Journal of Lipid Research, 56(4), 927-35. https://doi.org/10.1194/jlr.D056390
Ouairy, C. M. J., Ferraz, M. J., Boot, R. G., Baggelaar, M. P., van der Stelt, M., Appelman, M., van der Marel, G. A., Florea, B. I., Aerts, J. M. F. G., & Overkleeft, H. S. (2015). Development of an acid ceramidase activity-based probe. Chemical communications (Cambridge, England), 51(28), 6161-3. https://doi.org/10.1039/c5cc00356c
Baggelaar, M. P., Chameau, P. J. P., Kantae, V., Hummel, J., Hsu, K. L., Janssen, F., Van Der Wel, T., Soethoudt, M., Deng, H., Den Dulk, H., Allarà, M., Florea, B. I., Di Marzo, V., Wadman, W. J., Kruse, C. G., Overkleeft, H. S., Hankemeier, T., Werkman, T. R., Cravatt, B. F., & Van Der Stelt, M. (2015). Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. Journal of the American Chemical Society, 137(27), 8851-8857. https://doi.org/10.1021/jacs.5b04883
Janssen, F. J., Baggelaar, M. P., Hummel, J. J. A., Overkleeft, H. S., Cravatt, B. F., Boger, D. L., & Van Der Stelt, M. (2015). Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors. Journal of Medicinal Chemistry, 58(24), 9742-9753. https://doi.org/10.1021/acs.jmedchem.5b01627

2014

Scholarly publications

Janssen, F. J., Deng, H., Baggelaar, M. P., Allarà, M., van der Wel, T., den Dulk, H., Ligresti, A., van Esbroeck, A. C. M., McGuire, R., Di Marzo, V., Overkleeft, H. S., & van der Stelt, M. (2014). Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6. Journal of Medicinal Chemistry, 57(15), 6610-22. https://doi.org/10.1021/jm500681z

2013

Scholarly publications

Baggelaar, M. P., Huang, Y., Feringa, B. L., Dekker, F. J., & Minnaard, A. J. (2013). Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor. Bioorganic & Medicinal Chemistry, 21(17), 5271-4. https://doi.org/10.1016/j.bmc.2013.06.024
Baggelaar, M. P., Janssen, F. J., van Esbroeck, A. C. M., den Dulk, H., Allarà, M., Hoogendoorn, S., McGuire, R., Florea, B. I., Meeuwenoord, N., van den Elst, H., van der Marel, G. A., Brouwer, J., Di Marzo, V., Overkleeft, H. S., & van der Stelt, M. (2013). Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain. Angewandte Chemie-International Edition, 52(46), 12081-5. https://doi.org/10.1002/anie.201306295

2012

Scholarly publications

Barroso, S., Castelli, R., Baggelaar, M. P., Geerdink, D., ter Horst, B., Casas-Arce, E., Overkleeft, H. S., van der Marel, G. A., Codée, J. D. C., & Minnaard, A. J. (2012). Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from Mycobacterium tuberculosis. Angewandte Chemie-International Edition, 51(47), 11774-7. https://doi.org/10.1002/anie.201206221