Publications
2025
Scholarly publications
Nederstigt, A. E., Sardana, S., & Baggelaar, M. P. (2025). Deciphering protein long-chain S-acylation using mass spectrometry proteomics strategies. RSC Chemical Biology. [DOI]
2024
Scholarly publications
Ocasio, C. A., Baggelaar, M. P., Sipthorp, J., Losada de la Lastra, A., Tavares, M., Volarić, J., Soudy, C., Storck, E. M., Houghton, J. W., Palma-Duran, S. A., MacRae, J. I., Tomić, G., Carr, L., Downward, J., Eggert, U. S., & Tate, E. W. (2024). A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation. Nature Biotechnology, 42(10), 1548-1558. [DOI]
Tomić, G., Sheridan, C., Refermat, A. Y., Baggelaar, M. P., Sipthorp, J., Sudarshan, B., Ocasio, C. A., Suárez-Bonnet, A., Priestnall, S. L., Herbert, E., Tate, E. W., & Downward, J. (2024). Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis. Cell Reports, 43(5), Article 114224. [DOI]
Kaiyrzhanov, R., Rad, A., Lin, S.-J., Bertoli-Avella, A., Kallemeijn, W. W., Godwin, A., Zaki, M. S., Huang, K., Lau, T., Petree, C., Efthymiou, S., Ghayoor Karimiani, E., Hempel, M., Normand, E. A., Rudnik-Schöneborn, S., Schatz, U. A., Baggelaar, M. P., Ilyas, M., Sultan, T., ... Maroofian, R. (2024). Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. Brain, 147(4), 1436-1456. [DOI] [Repository]
2023
Scholarly publications
Tomić, G., Sheridan, C., Refermat, A. Y., Baggelaar, M. P., Sipthorp, J., Sudarshan, B., Ocasio, C. A., Suárez-Bonnet, A., Priestnall, S. L., Herbert, E., Tate, E. W., & Downward, J. (2023, Feb 8). Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis. [DOI]
Ocasio, C. A., Baggelaar, M., Sipthorp, J., Losada de la Lastra, A., Volarić, J., Soudy, C., Storck, E. M., Palma-Duran, S. A., MacRae, J. I., Tomic, G., Carr, L., Downward, J., S. Eggert, U., & Tate, E. W. (2023). A palmitoyl transferase chemical genetic system to map ZDHHC-specific S-acylation. (bioRxiv). bioRxiv. [DOI] [Repository]
Tomic, G., Refermat, A. Y., Sheridan, C., Baggelaar, M., Sipthorp, J., Sudarshan, B., Ocasio, C. A., Suárez-Bonnet, A., Priestnall , S. L., Herbert, E., Tate, E. W., & Downward, J. (2023). Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis. (bioRxiv). bioRxiv. [DOI] [Repository]
van Bergen, W., Fiala, J., Heck, AJ., & Baggelaar, M. (2023). Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs. (pp. 1-28 ). bioRxiv. [DOI] [Repository]
Sardana, S., Nederstigt, R., & Baggelaar, M. (2023). S‑Palmitoylation during Retinoic Acid-Induced Neuronal Differentiation of SH-SY5Y Neuroblastoma Cells. Journal of Proteome Research, 22(7), 2421–2435. [DOI] [Repository]
van Bergen, W., Hevler, J. F., Wu, W., Baggelaar, M. P., & Heck, A. J. R. (2023). Site-specific Activity-based Protein Profiling Using Phosphonate Handles. Molecular and Cellular Proteomics, 22(1), 1-15. Article 100455. [DOI] [Repository]
2022
Scholarly publications
van Bergen, W., Heck, A. J. R., & Baggelaar, M. P. (2022). Recent advancements in mass spectrometry-based tools to investigate newly synthesized proteins. Current Opinion in Chemical Biology, 66, Article 102074. [DOI] [Repository]
2019
Scholarly publications
Baggelaar, M. P., den Dulk, H., Florea, B. I., Fazio, D., Bernabò, N., Raspa, M., Janssen, A. P. A., Scavizzi, F., Barboni, B., Overkleeft, H. S., Maccarrone, M., & van der Stelt, M. (2019). ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction. ACS Chemical Biology. [DOI]
Zhou, J., Mock, E. D., Martella, A., Kantae, V., Di, X., Burggraaff, L., Baggelaar, M. P., Al-Ayed, K., Bakker, A., Florea, B. I., Grimm, S. H., den Dulk, H., Li, C. T., Mulder, L., Overkleeft, H. S., Hankemeier, T., van Westen, G. J. P., & van der Stelt, M. (2019). Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI. ACS Chemical Biology, 14(2), 164-169. [DOI]
Baggelaar, M. P., den Dulk, H., Florea, B. I., Fazio, D., Perruzza, D., Bernabò, N., Raspa, M., Janssen, A. P. A., Scavizzi, F., Barboni, B., Overkleeft, H. S., Maccarrone, M., & van der Stelt, M. (2019). ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction. ACS Chemical Biology, 14(12), Article 2943. [DOI]
2018
Scholarly publications
van Rooden, E. J., Florea, B. I., Deng, H., Baggelaar, M. P., van Esbroeck, A. C. M., Zhou, J., Overkleeft, H. S., & van der Stelt, M. (2018). Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification. Nature protocols, 13(4), 752-767. [DOI]
Baggelaar, M. P., Maccarrone, M., & van der Stelt, M. (2018). 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain. Progress in Lipid Research, 71, 1-17. [DOI]
van Rooden, E. J., van Esbroeck, A. C. M., Baggelaar, M. P., Deng, H., Florea, B. I., Marques, A. R. A., Ottenhoff, R., Boot, R. G., Overkleeft, H. S., Aerts, J. M. F. G., & van der Stelt, M. (2018). Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain. Frontiers in Neuroscience, 12, Article 440. [DOI]
2017
Scholarly publications
Deng, H., van der Wel, T., van den Berg, R. J. B. H. N., van den Nieuwendijk, A. M. C. H., Janssen, F. J., Baggelaar, M. P., Overkleeft, H. S., & van der Stelt, M. (2017). Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors. MedChemComm, 8(5), 982-988. [DOI]
Deng, H., Kooijman, S., van den Nieuwendijk, A. M. C. H., Ogasawara, D., van der Wel, T., van Dalen, F., Baggelaar, M. P., Janssen, F. J., van den Berg, R. J. B. H. N., den Dulk, H., Cravatt, B. F., Overkleeft, H. S., Rensen, P. C. N., & van der Stelt, M. (2017). Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. Journal of Medicinal Chemistry, 60(1), 428-440. [DOI]
Baggelaar, M. P., & Van der Stelt, M. (2017). Competitive ABPP of Serine Hydrolases: A Case Study on DAGL-Alpha. Methods in Molecular Biology, 1491, 161-169. [DOI]
Soethoudt, M., Grether, U., Fingerle, J., Grim, T. W., Fezza, F., de Petrocellis, L., Ullmer, C., Rothenhäusler, B., Perret, C., van Gils, N., Finlay, D., MacDonald, C., Chicca, A., Gens, M. D., Stuart, J., de Vries, H., Mastrangelo, N., Xia, L., Alachouzos, G., ... van der Stelt, M. (2017). Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity. Nature Communications, 8, Article 13958. [DOI]
Baggelaar, M. P., van Esbroeck, A. C. M., van Rooden, E. J., Florea, B. I., Overkleeft, H. S., Marsicano, G., Chaouloff, F., & van der Stelt, M. (2017). Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases. ACS Chemical Biology, 12(3), 852-861. [DOI]
van Esbroeck, A. C. M., Janssen, A. P. A., Cognetta, A. B., Ogasawara, D., Shpak, G., van der Kroeg, M., Kantae, V., Baggelaar, M. P., de Vrij, F. M. S., Deng, H., Allarà, M., Fezza, F., Lin, Z., van der Wel, T., Soethoudt, M., Mock, E. D., den Dulk, H., Baak, I. L., Florea, B. I., ... van der Stelt, M. (2017). Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474. Science (New York, N.Y.), 356(6342), 1084-1087. [DOI]
Petracca, R., Romeo, E., Baggelaar, M. P., Artola, M., Pontis, S., Ponzano, S., Overkleeft, H. S., van der Stelt, M., & Piomelli, D. (2017). Novel activity-based probes for N-acylethanolamine acid amidase. Chemical communications (Cambridge, England), 53(86), 11810-11813. [DOI]
2016
Scholarly publications
Mukhopadhyay, P., Baggelaar, M., Erdelyi, K., Cao, Z., Cinar, R., Fezza, F., Ignatowska-Janlowska, B., Wilkerson, J., van Gils, N., Hansen, T., Ruben, M., Soethoudt, M., Heitman, L., Kunos, G., Maccarrone, M., Lichtman, A., Pacher, P., & Van der Stelt, M. (2016). The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity. British Journal of Pharmacology, 173(3), 446-58. [DOI]
Ogasawara, D., Deng, H., Viader, A., Baggelaar, M. P., Breman, A., den Dulk, H., van den Nieuwendijk, A. M. C. H., Soethoudt, M., van der Wel, T., Zhou, J., Overkleeft, H. S., Sanchez-Alavez, M., Mori, S., Nguyen, W., Conti, B., Liu, X., Chen, Y., Liu, Q.-S., Cravatt, B. F., & van der Stelt, M. (2016). Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Proceedings of the National Academy of Sciences of the United States of America, 113(1), 26-33. [DOI]
2015
Scholarly publications
van der Wel, T., Janssen, F. J., Baggelaar, M. P., Deng, H., den Dulk, H., Overkleeft, H. S., & van der Stelt, M. (2015). A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α. Journal of Lipid Research, 56(4), 927-35. [DOI]
Ouairy, C. M. J., Ferraz, M. J., Boot, R. G., Baggelaar, M. P., van der Stelt, M., Appelman, M., van der Marel, G. A., Florea, B. I., Aerts, J. M. F. G., & Overkleeft, H. S. (2015). Development of an acid ceramidase activity-based probe. Chemical communications (Cambridge, England), 51(28), 6161-3. [DOI]
Baggelaar, M. P., Chameau, P. J. P., Kantae, V., Hummel, J., Hsu, K. L., Janssen, F., Van Der Wel, T., Soethoudt, M., Deng, H., Den Dulk, H., Allarà, M., Florea, B. I., Di Marzo, V., Wadman, W. J., Kruse, C. G., Overkleeft, H. S., Hankemeier, T., Werkman, T. R., Cravatt, B. F., & Van Der Stelt, M. (2015). Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. Journal of the American Chemical Society, 137(27), 8851-8857. [DOI]
Janssen, F. J., Baggelaar, M. P., Hummel, J. J. A., Overkleeft, H. S., Cravatt, B. F., Boger, D. L., & Van Der Stelt, M. (2015). Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors. Journal of Medicinal Chemistry, 58(24), 9742-9753. [DOI]
2014
Scholarly publications
Janssen, F. J., Deng, H., Baggelaar, M. P., Allarà, M., van der Wel, T., den Dulk, H., Ligresti, A., van Esbroeck, A. C. M., McGuire, R., Di Marzo, V., Overkleeft, H. S., & van der Stelt, M. (2014). Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6. Journal of Medicinal Chemistry, 57(15), 6610-6622. [DOI]
2013
Scholarly publications
Baggelaar, M. P., Huang, Y., Feringa, B. L., Dekker, F. J., & Minnaard, A. J. (2013). Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor. Bioorganic & Medicinal Chemistry, 21(17), 5271-4. [DOI]
Baggelaar, M. P., Janssen, F. J., van Esbroeck, A. C. M., den Dulk, H., Allarà, M., Hoogendoorn, S., McGuire, R., Florea, B. I., Meeuwenoord, N., van den Elst, H., van der Marel, G. A., Brouwer, J., Di Marzo, V., Overkleeft, H. S., & van der Stelt, M. (2013). Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain. Angewandte Chemie-International Edition, 52(46), 12081-5. [DOI]
2012
Scholarly publications
Barroso, S., Castelli, R., Baggelaar, M. P., Geerdink, D., ter Horst, B., Casas-Arce, E., Overkleeft, H. S., van der Marel, G. A., Codée, J. D. C., & Minnaard, A. J. (2012). Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from Mycobacterium tuberculosis. Angewandte Chemie-International Edition, 51(47), 11774-7. [DOI]