Dr. M.P. (Marc) Baggelaar

Assistant Professor
Biomol.Mass Spectrometry & Proteom.

RESEARCH EXPERIENCE

2020- Present    Utrecht University

Assistant professor, department of Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Biomulecular Mass Spectrometry and Proteomics.

2020 Utrecht University

Postdoctoral researcher, Biomolecular Mass spectrometry. Advisor: A.J.R. Heck, targeting protein palmitoylation as a possible regulator in neurological diseases (From 02-2020)

2018 – 2019   The Francis Crick Institute/ Imperial College London

H2020 Marie Sklodowska-Curie research fellow, secondment in the satellite lab of E.W. Tate, the role of protein lipidation in cancer (from 07/2018-10/2019)

2017 – 2018 Imperial College London

H2020 Marie Sklodowska-Curie research Fellow, Chemical Biology Advisor: E.W. Tate, the role of protein lipidation in cancer (07/2017 – 07/2018)

2017 Leiden University

Postdoctoral researcher, Molecular Physiology. Advisor: M. van der Stelt, activity-based protein profiling for identification of novel selective serine hydrolase inhibitors (04/2017 – 05/2017)

                

EDUCATION

2012 -2017                              Leiden University (Promotion, Cum Laude, April 6, 2017)

Ph.D. Bio-Organic Chemistry under supervision of Prof. Dr. M. van der Stelt and Prof. Dr. H. S. Overkleeft; Thesis title: Activity-based protein profiling of Diacylglycerol lipases

2012                                        University of Groningen

M.Sc. Organic Chemistry (Graduated on May 31, 2012)

2011                                        University of Groningen

B.Sc. Organic Chemistry (Graduated on May 31, 2011) 

 

AWARDS AND FELLOWSHIPS/FUNDING

 
2023 - NWO-M1 Open competition grant (350K) A greasy protein modification in cancer on the balance

2020 - Veni, NWO talent programme 2020 (250K) Targeting Protein Palmitoylation as a Possible Regulator in Neurological Diseases

2019 - Dutch Medicinal Chemistry prize 2017-2018 (1K) awarded for the best dissertation in the field of medicinal chemistry research published between 1 January 2017 and 31 December 2018. 

2017 - H2020 Marie Sklodowska-Curie individual fellowship 2017 (183K) Modulating and profiling receptor tyrosine kinase S-palmitoylation in breast cancer

2016 - International Cannabinoid Research Society (ICRS) travel award (0.5K) 

2012 - Unilever research prize 2012 (3.5K) for master thesis entitled “Catalytic asymmetric total synthesis of (S)-(−)-Zearalenone, a novel lipoxygenase  inhibitor”

 

INTERNSHIPS 
 

The department of Chemical Physiology, the Scripps research institute, CA, USA     

Prof. B. F. Cravatt, Ph.D.

Employed competitive activity-based proteomics to study target engagement and selectivity profiles of DAGL inhibitors in mouse tissues and in situ. In addition, the effect of DAGL inhibitors on substrate and product levels of DAGL was studied in situ and in vivo. (05/2014 – 08/2014)

Bio-organic synthesis, Leiden University, The Netherlands

Prof. Dr. H. S. Overkleeft and Prof. Dr. G. A. van der Marel                

Synthesis of a triglycoside that is part of a glycolipid that was isolated from the cell wall of Mycobacterium tuberculosis. (08/2011 - 12/2011)

Bio-organic Chemistry, Groningen University, The Netherlands   

Prof. dr. A.J. Minnaard

Catalytic asymmetric synthesis of (S)-(−)-zearalenone using asymmetric allylic alkylation for the introduction of the stereocenter. (S)-(−)-Zearalenone turned out to be a novel lipoxygenase inhibitor. (05/2010 – 06/2011)