Publications
2026
Scholarly publications
Kole, K., & Kole, M. H. P. (2026). Robust activity-dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation. Journal of Physiology, 604(7), 3032-3052. [DOI] [Repository]
Arafa, D., van de Korput, J., Braaker, P. N., Higgins, K. P., Meijns, N. R. C., Marshall-Phelps, K. L. H., Meng, J., Soong, D., Scalia, E., Lathem, K., Keatinge, M., Richmond, C., Klingseisen, A., Main, M., Neely, S. A., Hampton, D. W., Duncan, G. J., Schenk, G. J., Groot, M. L., ... Lyons, D. A. (2026). Myelin sheaths in the central nervous system can withstand damage and dynamically remodel. Science, 391(6786), Article eadr4661. [DOI] [Repository]
2025
Scholarly publications
Jamann, N., Montijn, J. S., Petersen, N., Lokhorst, R., van den Burg, D., Balemans, M., Driessens, S. L. W., Heimel, J. A., & Kole, M. H. P. (2025). Layer 5 myelination gates corticothalamic coincidence detection. Nature Communications, 16(1), Article 10922. [DOI] [Repository]
van der Vliet, D., Klinkenberg, A. X. Y., Platte, R., Higgins, K., Prokop, S., Huizenga, M. C. W., Kraaijevanger, L., van Egmond, N., Straub, V. M., Kole, M. H. P., Pacher, P., Katona, I., Huitinga, I., & van der Stelt, M. (2025). Spatially Resolved Mapping of Monoacylglycerol Lipase Activity in the Brain. ACS Chemical Neuroscience, 16(24), 4622-4635. [DOI] [Repository]
Triñanes-Ramos, J., Bugiani, M., van Rooijen-van Leeuwen, G., Chevalier, J. A., Siu, Y. J., van Utenhove, E. L. H., Hoogterp, L., Witkamp, D., Oudejans, E., Lodder, B., Kole, M., Saher, G., Nave, K.-A., Abbink, T. E. M., & van der Knaap, M. S. (2025). Cell-specific Eif2b5 mutant mice: novel insights into roles of macroglia in vanishing white matter. Brain, 148(11), 4112–4126. [DOI] [Repository]
2024
Scholarly publications
Seignette, K., Jamann, N., Papale, P., Terra, H., Porneso, R. O., de Kraker, L., van der Togt, C., van der Aa, M., Neering, P., Ruimschotel, E., Roelfsema, P. R., Montijn, J. S., Self, M. W., Kole, M. H. P., & Levelt, C. N. (2024). Experience shapes chandelier cell function and structure in the visual cortex. eLife, 12. [DOI] [Repository]
2023
Scholarly publications
Passchier, E. M. J., Kerst, S., Brouwers, E., Hamilton, E. M. C., Bisseling, Q., Bugiani, M., Waisfisz, Q., Kitchen, P., Unger, L., Breur, M., Hoogterp, L., de Vries, S. I., Abbink, T. E. M., Kole, M. H. P., Leurs, R., Vischer, H. F., Brignone, M. S., Ambrosini, E., Feillet, F., ... van der Knaap, M. S. (2023). Aquaporin-4 and GPRC5B: old and new players in controlling brain oedema. Brain, 146(8), 3444-3454. [DOI] [Repository]
Fréal, A., Jamann, N., Ten Bos, J., Jansen, J., Petersen, N., Ligthart, T., Hoogenraad, C. C., & Kole, M. H. P. (2023). Sodium channel endocytosis drives axon initial segment plasticity. Science advances, 9(37), 1-16. Article eadf3885. [DOI] [Repository]
Wilbers, R., Metodieva, V. D., Duverdin, S., Heyer, D. B., Galakhova, A. A., Mertens, E. J., Versluis, T. D., Baayen, J. C., Idema, S., Noske, D. P., Verburg, N., Willemse, R. B., de Witt Hamer, P. C., Kole, M. H. P., de Kock, C. P. J., Mansvelder, H. D., & Goriounova, N. A. (2023). Human voltage-gated Na+ and K+ channel properties underlie sustained fast AP signaling. Science advances, 9(41), Article eade3300. [DOI] [Repository]
Bosch, A. M. R. V. D., Hümmert, S., Steyer, A., Ruhwedel, T., Hamann, J., Smolders, J., Nave, KA., Stadelmann, C., Kole, M. H. P., Möbius, W., & Huitinga, I. (2023). Ultrastructural Axon–Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation. Annals of Neurology, 93(4), 856-870. [DOI] [Repository]
2022
Scholarly publications
Jamann, N., & Kole, M. H. P. (2022). Connecting axons and dendrites: An oblique view. Neuron, 110(9), 1438-1440. [DOI] [Repository]
Kole, K., Voesenek, B. J. B., Brinia, M. E., Petersen, N., & Kole, M. H. P. (2022). Parvalbumin basket cell myelination accumulates axonal mitochondria to internodes. Nature Communications, 13(1), Article 7598. [DOI] [Repository]
Dubey, M., Pascual-Garcia, M., Helmes, K., Wever, D. D., Hamada, M. S., Kushner, S. A., & Kole, M. HP. (2022). Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition. eLife, 11, Article e73827. [DOI] [Repository]
2021
Scholarly publications
Jamann, N., Dannehl, D., Lehmann, N., Wagener, R., Thielemann, C., Schultz, C., Staiger, J., Kole, M. H. P., & Engelhardt, M. (2021). Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex. Nature Communications, 12(1), 1-14. Article 23. [DOI] [Repository]
Siemons, M. E., Hanemaaijer, N. A. K., Kole, M. H. P., & Kapitein, L. C. (2021). Robust adaptive optics for localization microscopy deep in complex tissue. Nature Communications, 12(1), 1-9. Article 3407. [DOI] [Repository]
Ramaglia, V., Dubey, M., Malpede, M. A., Petersen, N., de Vries, S. I., Ahmed, S. M., Lee, D. S. W., Schenk, G. J., Gold, S. M., Huitinga, I., Gommerman, J. L., Geurts, J. J. G., & Kole, M. H. P. (2021). Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory. Acta Neuropathologica, 142, 643-667. [DOI] [Repository]
2020
Scholarly publications
Moore, S., Meschkat, M., Ruhwedel, T., Trevisiol, A., Tzvetanova, I. D., Battefeld, A., Kusch, K., Kole, M. H. P., Strenzke, N., Möbius, W., Hoz, L. D., & Nave, K.-A. (2020). A role of oligodendrocytes in information processing. Nature Communications, 11, Article 5497. [DOI] [Repository]
Hanemaaijer, N. AK., Popovic, M. A., Wilders, X., Grasman, S., Arocas, O. P., & Kole, M. HP. (2020). Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling. eLife. [DOI] [Repository]
Wolf, NI., Breur, M., Plug, B., Beerepoot, S., Westerveld, ASR., van, R. DF., de, V. SI., Kole, MHP., Vanderver, A., van, D. K. MS., Lindemans, CA., dummy-AUTHOR_name, & Bugiani, M. (2020). Metachromatic leukodystrophy and transplantation: remyelination, no cross-correction. Annals of Clinical and Translational Neurology, 7(2), 169-180. [DOI] [Repository]
2019
Scholarly publications
Cohen, CCH., Popovic, MA., Klooster, J., Weil, MT., Möbius, W., Nave, KA., & Kole, MHP. (2019). Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit. Cell, 180(2), 311-322. Article E15. [DOI] [Repository]
Byczkowicz, N., Eshra, A., Montanaro, J., Trevisiol, A., Hirrlinger, J., Kole, M. H., Shigemoto, R., & Hallermann, S. (2019). HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons. eLife, 8. [DOI] [Repository]
Battefeld, A., Popovic, M. A., de Vries, S. I., & Kole, M. H. P. (2019). High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling. Cell Reports, 26(1), 182-191. [DOI] [Repository]
Battefeld, A., Popovic, M. A., van der Werf, D., & Kole, M. H. P. (2019). A Versatile and Open-Source Rapid LED Switching System for One-Photon Imaging and Photo-Activation. Frontiers in Cellular Neuroscience, 12, Article 530. [DOI] [Repository]
2018
Scholarly publications
Dubey, M., Brouwers, E., Hamilton, E. M. C., Stiedl, O., Bugiani, M., Koch, H., Kole, M. H. P., Boschert, U., Wykes, R. C., Mansvelder, H. D., van der Knaap, M. S., & Min, R. (2018). Seizures and disturbed brain potassium dynamics in the leukodystrophy megalencephalic leukoencephalopathy with subcortical cysts. Annals of Neurology, 83(3), 636-649. [DOI] [Repository]
Kole, M. H., & Brette, R. (2018). The electrical significance of axon location diversity. Current Opinion in Neurobiology, 51, 52-59. [DOI] [Repository]
Klok, M. D., Bugiani, M., de Vries, S. I., Gerritsen, W., Breur, M., van der Sluis, S., Heine, V. M., Kole, M. H. P., Baron, W., & van der Knaap, M. S. (2018). Axonal abnormalities in vanishing white matter. Annals of Clinical and Translational Neurology, 5(4), 429-444. [DOI] [Repository]
2017
Scholarly publications
Hamada, M. S., Popovic, M., & Kole, M. H. P. (2017). Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons. Frontiers in Cellular Neuroscience, 11, 45. [DOI] [Repository]
2016
Scholarly publications
Hamada, M. S., Goethals, S., de Vries, S. I., Brette, R., & Kole, M. H. P. (2016). Covariation of axon initial segment location and dendritic tree normalizes the somatic action potential. Proceedings of the National Academy of Sciences of the United States of America, 113(51), 14841-14846. [DOI] [Repository]
Battefeld, A., Klooster, J., & Kole, M. H. P. (2016). Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Nature Communications, 7, Article 11298. [DOI] [Repository]
2015
Scholarly publications
Hamada, M. S., & Kole, M. H. P. (2015). Myelin loss and axonal ion channel adaptations associated with gray matter neuronal hyperexcitability. Journal of Neuroscience, 35(18), 7272-86. [DOI] [Repository]
2014
Scholarly publications
Kole, M., & Cooper, E. C. (2014). Axonal Kv7.2/7.3 channels: Caught in the act. Channels, 8(4), 288-289. [DOI] [Repository]
Battefeld, A., Tran, B. T., Gavrilis, J., Cooper, E. C., & Kole, M. (2014). Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons. Journal of Neuroscience, 34(10), 3719-3732. [DOI] [Repository]
Other output
Battefeld, A., Klooster, J., & Kole, M. (2014). An oligodendrocyte-astrocyte microcircuit siphons [K+]0 at ation potential resolution. Poster session presented at Physiology meeting, London, United Kingdom.