prof. dr. M.H.M. (Marca) Wauben
M.H.M.Wauben@uu.nl
Gegenereerd op 2017-10-17 16:44:51


Chair
Intercellulaire Communicatie
Inaugural lecture date 19.09.2012
Profile

Research aim

My research group aims to unravel the role of intercellular communication in biological systems via extracellular vesicles with specific emphasis on the regulation of the immune system. Nowadays cell-derived vesicles are being recognized as important messengers comprised of selected proteins, (small)RNAs and lipids involved in the modulation of specific target cells.  The main focus of the research is on the (functional) characterization of vesicle populations involved in immune cell regulation. For this we use proteomics, genomics and lipidomics approaches and employ a high resolution flow cytometry-based method developed by my group which enables quantitative and qualitative analysis of individual nano-sized vesicles. We aim to identify immune-regulatory vesicles in body fluids, e.g. in breast milk and blood, and try to reveal their origin and factors that influence the selection of vesicular cargo and the release of different immune-regulatory vesicle subsets. Besides fundamental research we exploit whether specific vesicular-signatures in body fluids may be used as biomarkers, and we aim to develop cell-derived vesicle inspired nano-carriers for clinical application.

 

 

Scientific expertise

Local Organizing Committee ISEV2014 (Rotterdam, The Netherlands). Front row (from left to right): Rienk Nieuwland (Amsterdam), Raymond Schiffelers (Utrecht), Esther Nolte- 't Hoen (Utrecht) and Marca Wauben (President LOC ISEV2014; Utrecht). Back row (from left to right): Petra Boon (Utrecht), Michiel Pegtel (Amsterdam), Hans van Leeuwen (Rotterdam)
Gegenereerd op 2017-10-17 16:44:51
Curriculum vitae

Marca Wauben (1964) heads the research group Intercellular Communication of the Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine. She studied Biology at Utrecht University and performed her graduate research at the Department of Infectious Diseases & Immunology, Utrecht University. She received her PhD cum laude (1993). Postdoctoral training was performed at Utrecht University and at the University of California San Diego, USA (Prof. S. Albani). She became fellow of the Royal Academy of Arts and Sciences of the Netherlands (1997-2002). As associate professor she established her own research groups at Utrecht University, Department of Infectious Diseases & Immunology (2001-2004) and at Leiden University Medical Center, Department of Immunohematology and Blood Transfusion (2004-2006).In 2006 she moved to Utrecht University, Department Biochemistry & Cell Biology, Faculty of Veterinary Medicine. In 2011 she became full professor Intercellular Communication at this Department. Her research group focuses on the role of cell-derived vesicles in intercellular communication. She is member of the Board of Examiners Life Sciences Utrecht University and one of the leaders of Future Food Utrecht (www.uu.nl/futurefood).

Gegenereerd op 2017-10-17 16:44:51
All publications
  Articles - 2017
Van Deun, Jan, Mestdagh, Pieter, Agostinis, Patrizia, Akay, Özden, Anand, Sushma, Anckaert, Jasper, Martinez, Zoraida Andreu, Baetens, Tine, Beghein, Els, Bertier, Laurence, Berx, Geert, Boere, Janneke, Boukouris, Stephanie, Bremer, Michel, Buschmann, Dominik, Byrd, James B, Casert, Clara, Cheng, Lesley, Cmoch, Anna, Daveloose, Delphine, De Smedt, Eva, Demirsoy, Seyma, Depoorter, Victoria, Dhondt, Bert, Driedonks, Tom A P, Dudek, Aleksandra, Elsharawy, Abdou, Floris, Ilaria, Foers, Andrew D, Gärtner, Kathrin, Garg, Abhishek D, Geeurickx, Edward, Gettemans, Jan, Ghazavi, Farzaneh, Giebel, Bernd, Kormelink, Tom Groot, Hancock, Grace, Helsmoortel, Hetty, Hill, Andrew F, Hyenne, Vincent, Kalra, Hina, Kim, David, Kowal, Joanna, Kraemer, Sandra, Leidinger, Petra, Leonelli, Carina, Liang, Yaxuan, Lippens, Lien, Liu, Shu, Lo Cicero, Alessandra, Martin, Shaun, Mathivanan, Suresh, Mathiyalagan, Prabhu, Matusek, Támas, Milani, Gloria, Monguió-Tortajada, Marta, Mus, Liselot M, Muth, Dillon C, Németh, Andrea, Nolte-'t Hoen, Esther N M, O'Driscoll, Lorraine, Palmulli, Roberta, Pfaffl, Michael W, Primdal-Bengtson, Bjarke, Romano, Erminia, Rousseau, Quentin, Sahoo, Susmita, Sampaio, Natalia, Samuel, Monisha, Scicluna, Benjamin, Soen, Bieke, Steels, Anneleen, Swinnen, Johannes V, Takatalo, Maarit, Thaminy, Safia, Théry, Clotilde, Tulkens, Joeri, Van Audenhove, Isabel, van der Grein, Susanne, Van Goethem, Alan, van Herwijnen, Martijn J, Van Niel, Guillaume, Van Roy, Nadine, Van Vliet, Alexander R, Vandamme, Niels, Vanhauwaert, Suzanne, Vergauwen, Glenn, Verweij, Frederik, Wallaert, Annelynn, Wauben, Marca, Witwer, Kenneth W, Zonneveld, Marijke I, De Wever, Olivier, Vandesompele, Jo, Hendrix, An & , (28.02.2017). EV-TRACK - transparent reporting and centralizing knowledge in extracellular vesicle research. Nature Methods, 14 (3), (pp. 228-232) (5 p.).
Mateescu, Bogdan, Kowal, Emma J K, van Balkom, Bas W M, Bartel, Sabine, Bhattacharyya, Suvendra N, Buzás, Edit I, Buck, Amy H, de Candia, Paola, Chow, Franklin W N, Das, Saumya, Driedonks, Tom A P, Fernández-Messina, Lola, Haderk, Franziska, Hill, Andrew F, Jones, Jennifer C, Van Keuren-Jensen, Kendall R, Lai, Charles P, Lässer, Cecilia, Liegro, Italia di, Lunavat, Taral R, Lorenowicz, Magdalena J, Maas, Sybren L N, Mäger, Imre, Mittelbrunn, Maria, Momma, Stefan, Mukherjee, Kamalika, Nawaz, Muhammed, Pegtel, D Michiel, Pfaffl, Michael W, Schiffelers, Raymond M, Tahara, Hidetoshi, Théry, Clotilde, Tosar, Juan Pablo, Wauben, Marca H M, Witwer, Kenneth W & Nolte-'t Hoen, Esther N M (07.03.2017). Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper. Journal of Extracellular Vesicles, 6 (1), (pp. 2001-3078).
  Articles - 2016
Deddens, Janine C, Vrijsen, Krijn R, Colijn, Johanna M, Oerlemans, Martinus I, Metz, Corina H G, van der Vlist, Els J, Nolte-'t Hoen, Esther N M, den Ouden, Krista, Jansen Of Lorkeers, Sanne J, van der Spoel, Tycho I G, Koudstaal, Stefan, Arkesteijn, Ger J, Wauben, Marca H M, van Laake, Linda W, Doevendans, Pieter A, Chamuleau, Steven A J & Sluijter, Joost P G (06.07.2016). Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury. Journal of Cardiovascular Translational Research, 9 (4), (pp. 291-301).
van Herwijnen, Martijn J C, Zonneveld, Marijke I, Goerdayal, Soenita, Nolte-'t Hoen, Esther N M, Garssen, Johan, Stahl, Bernd, Altelaar, A F Maarten, Redegeld, Frank A & Wauben, Marca H M (01.11.2016). Comprehensive proteomic analysis of human milk-derived extracellular vesicles unveils a novel functional proteome distinct from other milk components. Molecular and Cellular Proteomics, 15 (11), (pp. 3412-3423) (12 p.). Copyright © 2016, The American Society for Biochemistry and Molecular Biology..
Cheung, Kei-Hoi, Keerthikumar, Shivakumar, Roncaglia, Paola, Subramanian, Sai Lakshmi, Roth, Matthew E, Samuel, Monisha, Anand, Sushma, Gangoda, Lahiru, Gould, Stephen, Alexander, Roger, Galas, David, Gerstein, Mark B, Hill, Andrew F, Kitchen, Robert R, Lötvall, Jan, Patel, Tushar, Procaccini, Dena C, Quesenberry, Peter, Rozowsky, Joel, Raffai, Robert L, Shypitsyna, Aleksandra, Su, Andrew I, Théry, Clotilde, Vickers, Kasey, Wauben, Marca H M, Mathivanan, Suresh, Milosavljevic, Aleksandar & Laurent, Louise C (2016). Extending gene ontology in the context of extracellular RNA and vesicle communication. Journal of Biomedical Semantics, 7.
Malda, Jos, Boere, Janneke, van de Lest, Chris H A, van Weeren, P René & Wauben, Marca H M (2016). Extracellular vesicles - new tool for joint repair and regeneration. Nature reviews. Rheumatology, 12, (pp. 243-249).
Groot Kormelink, Tom, Arkesteijn, Ger J A, van de Lest, Chris H A, Geerts, Willie J C, Goerdayal, Soenita, Altelaar, Maarten A F, Redegeld, Frank A, Nolte-'t Hoen, Esther N M & Wauben, Marca H M (15.10.2016). Mast Cell Degranulation Is Accompanied by the Release of a Selective Subset of Extracellular Vesicles That Contain Mast Cell-Specific Proteases. Journal of Immunology, 197 (8), (pp. 3382-3392) (11 p.). Copyright © 2016 by The American Association of Immunologists, Inc..
van Eijndhoven, Monique A J, Zijlstra, Josée M, Groenewegen, Nils J, Drees, Esther E E, van Niele, Stuart, Baglio, S Rubina, Koppers-Lalic, Danijela, van der Voorn, Hans, Libregts, Sten F W M, Wauben, Marca H M, de Menezes, Renee X, van Weering, Jan R T, Nieuwland, Rienk, Visser, Lydia, van den Berg, Anke, de Jong, Daphne & Pegtel, D Michiel (2016). Plasma vesicle miRNAs for therapy response monitoring in Hodgkin lymphoma patients. JCI Insight, 1 (19).
Cointe, S, Judicone, C, Robert, S, Mooberry, M J, Poncelet, P, Wauben, M, Nieuwland, R, Key, N S, Dignat-George, F & Lacroix, R (23.09.2016). Standardization of microparticle enumeration across different flow cytometry platforms - results of a multicenter collaborative workshop. Journal of Thrombosis and Haemostasis, 15 (1), (pp. 187–193). This article is protected by copyright. All rights reserved..
Boere, Janneke, van de Lest, Chris H A, Libregts, Sten F W M, Arkesteijn, Ger J A, Geerts, Willie J C, Nolte-'t Hoen, Esther N M, Malda, Jos, van Weeren, P René & Wauben, Marca H M (2016). Synovial fluid pretreatment with hyaluronidase facilitates isolation of CD44+ extracellular vesicles. Journal of Extracellular Vesicles, 5.
Gardiner, Chris, Di Vizio, Dolores, Sahoo, Susmita, Théry, Clotilde, Witwer, Kenneth W, Wauben, Marca & Hill, Andrew F (2016). Techniques used for the isolation and characterization of extracellular vesicles - results of a worldwide survey. Journal of Extracellular Vesicles, 5.
  Articles - 2015
Lener, Thomas, Gimona, Mario, Aigner, Ludwig, Börger, Verena, Buzas, Edit, Camussi, Giovanni, Chaput, Nathalie, Chatterjee, Devasis, Court, Felipe A, Del Portillo, Hernando A, O'Driscoll, Lorraine, Fais, Stefano, Falcon-Perez, Juan M, Felderhoff-Mueser, Ursula, Fraile, Lorenzo, Gho, Yong Song, Görgens, André, Gupta, Ramesh C, Hendrix, An, Hermann, Dirk M, Hill, Andrew F, Hochberg, Fred, Horn, Peter A, de Kleijn, Dominique, Kordelas, Lambros, Kramer, Boris W, Krämer-Albers, Eva-Maria, Laner-Plamberger, Sandra, Laitinen, Saara, Leonardi, Tommaso, Lorenowicz, Magdalena J, Lim, Sai Kiang, Lötvall, Jan, Maguire, Casey A, Marcilla, Antonio, Nazarenko, Irina, Ochiya, Takahiro, Patel, Tushar, Pedersen, Shona, Pocsfalvi, Gabriella, Pluchino, Stefano, Quesenberry, Peter, Reischl, Ilona G, Rivera, Francisco J, Sanzenbacher, Ralf, Schallmoser, Katharina, Slaper-Cortenbach, Ineke, Strunk, Dirk, Tonn, Torsten, Vader, Pieter, van Balkom, Bas W M, Wauben, Marca, Andaloussi, Samir El, Théry, Clotilde, Rohde, Eva & Giebel, Bernd (2015). Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper. Journal of Extracellular Vesicles, 4 (1).
Yáñez-Mó, María, Siljander, Pia R-M, Andreu, Zoraida, Zavec, Apolonija Bedina, Borràs, Francesc E, Buzas, Edit I, Buzas, Krisztina, Casal, Enriqueta, Cappello, Francesco, Carvalho, Joana, Colás, Eva, Cordeiro-da Silva, Anabela, Fais, Stefano, Falcon-Perez, Juan M, Ghobrial, Irene M, Giebel, Bernd, Gimona, Mario, Graner, Michael, Gursel, Ihsan, Gursel, Mayda, Heegaard, Niels H H, Hendrix, An, Kierulf, Peter, Kokubun, Katsutoshi, Kosanovic, Maja, Kralj-Iglic, Veronika, Krämer-Albers, Eva-Maria, Laitinen, Saara, Lässer, Cecilia, Lener, Thomas, Ligeti, Erzsébet, Linē, Aija, Lipps, Georg, Llorente, Alicia, Lötvall, Jan, Manček-Keber, Mateja, Marcilla, Antonio, Mittelbrunn, Maria, Nazarenko, Irina, Nolte-'t Hoen, Esther N M, Nyman, Tuula A, O'Driscoll, Lorraine, Olivan, Mireia, Oliveira, Carla, Pállinger, Éva, Del Portillo, Hernando A, Reventós, Jaume, Rigau, Marina, Rohde, Eva, Sammar, Marei, Sánchez-Madrid, Francisco, Santarém, N, Schallmoser, Katharina, Ostenfeld, Marie Stampe, Stoorvogel, Willem, Stukelj, Roman, Van der Grein, Susanne G, Vasconcelos, M Helena, Wauben, Marca H M & De Wever, Olivier (2015). Biological properties of extracellular vesicles and their physiological functions. Journal of Extracellular Vesicles, 4, (pp. 27066).
Zonneveld, Marijke, Van Herwijnen, Martijn, Brouwers, Jos, Garssen, Johan, Redegeld, Frank, Nolte-'t Hoen, Esther & Wauben, Marca (01.01.2015). Defined breast milk EV subsets boost the immune response and skew the T-cell balance towards a regulatory phenotype. Journal of Extracellular Vesicles, 4, (pp. 28) (1 p.).
Van Herwijnen, Martijn, Zonneveld, Marijke, Goerdayal, Soenita, Altelaar, Maarten, Hoen, Esther Nolte't, Garssen, Johan, Redegeld, Frank & Wauben, Marca (01.01.2015). In-depth proteomics analysis of human breast milk-derived extracellular vesicles to reveal their origin and targets in the infant's developing immune system. Journal of Extracellular Vesicles, 4, (pp. 81) (1 p.).
Maas, Sybren L N, De Vrij, Jeroen, Van Der Vlist, Els J., Geragousian, Biaina, Van Bloois, Louis, Mastrobattista, Enrico, Schiffelers, Raymond M., Wauben, Marca H M, Broekman, Marike L D & Nolte-'T Hoen, Esther N M (28.02.2015). Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics. Journal of Controlled Release, 200, (pp. 87-96) (10 p.).
Kormelink, Tom Groot, Arkesteijn, Ger J A, Nauwelaers, Frans A, van den Engh, Ger, Nolte - t Hoen, Esther & Wauben, Marca H M (16.02.2015). Prerequisites for the analysis and sorting of extracellular vesicle subpopulations by high-resolution flow cytometry. Cytometry. Part A : the journal of the International Society for Analytical Cytology © 2015 International Society for Advancement of Cytometry..
  Articles - 2014
Kranendonk, Mariëtte E G, Visseren, Frank L J, van Herwaarden, Joost A, Nolte-'t Hoen, Esther N M, de Jager, Wilco, Wauben, Marca H M, Kalkhoven, Eric & Nolte - t Hoen, Esther (2014). Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells. Obesity, 22 (10), (pp. 2216-2223) (8 p.). Copyright © 2014 The Obesity Society..
Kranendonk, Mariëtte E G, Visseren, Frank L J, van Balkom, Bas W M, Nolte-'t Hoen, Esther N M, van Herwaarden, Joost A, de Jager, Wilco, Schipper, Henk S, Brenkman, Arjan B, Verhaar, Marianne C, Wauben, Marca H M & Kalkhoven, Eric (2014). Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages. Obesity, 22 (5), (pp. 1296-1308) (13 p.). Copyright © 2013 The Obesity Society..
Lötvall, Jan, Hill, Andrew F, Hochberg, Fred, Buzás, Edit I, Di Vizio, Dolores, Gardiner, Christopher, Gho, Yong Song, Kurochkin, Igor V, Mathivanan, Suresh, Quesenberry, Peter, Sahoo, Susmita, Tahara, Hidetoshi, Wauben, Marca H, Witwer, Kenneth W & Théry, Clotilde (2014). Minimal experimental requirements for definition of extracellular vesicles and their functions - a position statement from the International Society for Extracellular Vesicles. Journal of Extracellular Vesicles, 3, (pp. 26913).
Zonneveld, Marijke I, Brisson, Alain R, van Herwijnen, Martijn J C, Tan, Sisareuth, van de Lest, Chris H A, Redegeld, Frank A, Garssen, Johan, Wauben, Marca H M & Nolte - t Hoen, Esther (2014). Recovery of extracellular vesicles from human breast milk is influenced by sample collection and vesicle isolation procedures. Journal of Extracellular Vesicles, 3.
  Articles - 2013
Brouwers, J.F.H.M., Aalberts, M., Jansen, J.W.A., van Niel, G., Wauben, M.H.M., Stout, T.A.E., Helms, J.B. & Stoorvogel, W. (2013). Distinct lipid compositions of two types of human prostasomes. Proteomics, 13, (pp. 1660-1666) (7 p.).
Nolte-'t Hoen, E.N.M., van der Vlist, E.J., de Boer-Brouwer, M., Arkesteijn, G., Stoorvogel, W. & Wauben, M.H.M. (2013). Dynamics of dendritic cell-derived vesicles: high-resolution flow cytometric analysis of extracellular vesicle quantity and quality. Journal of Leukocyte Biology, 93, (pp. 395-402) (8 p.).
Aalberts, M., Sostaric, E., Wubbolts, R.W., Wauben, M.H.M., Nolte-'t Hoen, E.N.M., Gadella, B.M., Stout, T.A.E. & Stoorvogel, W. (2013). Spermatozoa recruit prostasomes in response to capacitation induction. Biochimica et Biophysica Acta - Proteins and Proteomics, 1834 ((11)), (pp. 2326-2335) (10 p.).
Witwer, K.W., Buza´ s, E.L., Bemis, L.T., Bora, A., Lässer, C., Lötvall, J., Nolte-'t Hoen, E.N.M., Piper, M.G., Sivaraman, S., Skog, J., Théry, C., Wauben, M.H.M. & Hochberg, F. (2013). Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. Journal of Extracellular Vesicles, 2, (pp. 20360) (25 p.).
  Articles - 2012
van der Vlist, E.J., Arkesteijn, G., van de Lest, C.H.A., Stoorvogel, W., Nolte-'t Hoen, E.N.M. & Wauben, M.H.M. (2012). CD4+ T cell activation promotes the differential release of distinct populations of nanosized vesicles. Journal of Extracellular Vesicles
Nolte-'t Hoen, E.N.M., Buermans, H.P., Waasdorp, M., Stoorvogel, W., Wauben, M.H.M. & `t Hoen, P.A.C. (2012). Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions. Nucleic Acids Research, 40 (18), (pp. 9272-9285) (14 p.).
Wauben, M.H.M. (15.10.2012). Dialoog met de kleine dingen van het leven, Oratie artikel. Vetgedrukt (1 p.).
van der Vlist, E.J., Nolte-'t Hoen, E.N.M., Stoorvogel, W., Arkesteijn, G. & Wauben, M.H.M. (2012). Fluorescent labeling of nano-sized vesicles released by cells and subsequent quantitative and qualitative analysis by high-resolution flow cytometry. Nature Protocols, Jun 14;7 (7), (pp. 1311-1326) (17 p.).
Aalberts, M., van Dissel-Emiliani, F.M.F., van Adrichem, N.P.H., van Wijnen, M., Wauben, M.H.M., Stout, T.A.E. & Stoorvogel, W. (2012). Identification of distinct populations of prostasomes that differentially express prostate stem cell antigen,Annexin A1, and GLIPR2 in Humans. Biology of Reproduction, Mar 22;86 (3; 82), (pp. 1-8) (8 p.).
Nolte-'t Hoen, E.N.M. & Wauben, M.H.M. (2012). Immune cell-derived vesicles: modulators and mediators of inflammation. Current Pharmaceutical Design, 18 (16), (pp. 2357-2368) (10 p.).
Wauben, M.H.M. (01.05.2012). Message in a vesicle artikel over de 1e ISEV meeting. Vetgedrukt (2 p.).
Wauben, M.H.M. (12.01.2012). Moedermelk: op zoek naar het geheime recept. (Danone Samenwerking). Vetgedrukt (2 p.).
Nolte - t Hoen, Esther N M, van der Vlist, Els J., Aalberts, Marian, Mertens, Hendrik C H, Bosch, Berend Jan, Bartelink, Willem, Mastrobattista, Enrico, van Gaal, Ethlinn V B, Stoorvogel, Willem, Arkesteijn, Ger J.A. Arkesteijn & Wauben, Marca H M (2012). Quantitative and qualitative flow cytometric analysis of nanosized cell-derived membrane vesicles. Nanomedicine: Nanotechnology, Biology, and Medicine, 8 (5), (pp. 712-720) (9 p.).
Lotvall, J., Rajendran, L., Song Gho, Y., Thery, C., Wauben, M.H.M., Raposo, G., Sjostrand, M., Taylor, D., Telemo, E. & Breakefield, X.O. (2012). The launch of Journal of Extracellular Vesicles (JEV), the official journal of the International Society for Extracellular Vesicles about microvesicles exosomes, ectosomes and other extracellular vesicles. Journal of Extracellular Vesicles, 1, (pp. http://dx.doi.org/10.3402/jev.v1i0.18514) (1 p.).
Kalra, H., Simpson, R.J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V.C., Borras, F.E., Breakefield, X., Budnik, V., Buzas, E., Camussi, G., Clayton, A., Cocucci, E., Falcon-Perez, J.M., Gabrielsson, S., Gho, Y.S., Gupta, D., Harsha, H.C., Hendrix, A., Hill, A.F., Inal, J.M., Jenster, G., Kramer-Albers, E.M., Lim, S.K., Llorente, A., Lotvall, J., Marcilla, A., Mincheva-Nilsson, L., Nazarenko, I., Nieuwland, R., Nolte-'t Hoen, E.N.M., Pandey, A, Patel, T., Piper, M.G., Pluchino, S., Prasad, T.S., Rajendran, L., Raposo, G., Record, M., Reid, G.E., Sanchez-Madrid, F., Schiffelers, R.M., Siljander, P., Stensballe, A., Stoorvogel, W., Taylor, D., Thery, C., Valadi, H., van Balkom, B.W.M., Vazquez, J., Vidal, M., Wauben, M.H.M., Yanez-Mo, M., Zoeller, M. & Mathivanan, S. (2012). Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biology, 10 (12), (pp. 10.1371/ journal.pbio.1001450) (1 p.).
  Articles - 2011
ten Broeke, A.G., van Niel, G., Wauben, M.H.M., Wubbolts, R.W. & Stoorvogel, W. (2011). Endosomally stored MHC Class II does not contribute to antigen presentation by dendritic cells at inflammatory conditions. Traffic, 12, (pp. 1025-1036) (11 p.).
van den Hoven, JM, Hofkens, W., Wauben, M.H.M., Wagenaar-Hilbers, J.P.A., Beijnen, J.H., Nuijen, B., Metselaar, J.M. & Storm, G. (2011). Optimizing the therapeutic index of liposomal glucocorticoids in experimental arthritis. International Journal of Pharmaceutics, 416 (2), (pp. 471-7) (7 p.).
  Articles - 2010
Buschow, S.I., van Balkom, B.W.M., Aalberts, M., Heck, A.J.R., Wauben, M.H.M. & Stoorvogel, W. (2010). MHC class II-associated proteins in B-cells exosomes and potential functional implications for exosome biogenesis. Immunology and Cell Biology, 88 (8), (pp. 851-856) (6 p.).
Wauben, M.H.M., Toes, R.E., Bos, N.A., Damoiseaux, J., van Ham, S.M., van de Loosdrecht, A.A. & Samsom, J.N. (2010). Sensing and signaling by the immune system. NVVI-Dutch Society for immunology Course Lunteren 2-3 2009. Immunology Letters, 128, (pp. 1-3) (3 p.).
ten Broeke, A.G., de Graaff, A.M., van 't Veld, E.M., Wauben, M.H.M., Stoorvogel, W. & Wubbolts, R.W. (2010). Trafficking of MHC Class II in dendritic cells is dependent on but not regulated by degradation of its associated invariant chain. Traffic, 11, (pp. 324-331) (8 p.).
  Articles - 2009
Nolte-'t Hoen, E.N.M., Buschow, S.I., Anderton, S.M., Stoorvogel, W. & Wauben, M.H.M. (2009). Activated T cells recruit exosomes secreted by dendritic cells via LFA-1. Blood, 113 (9), (pp. 1977-1981) (5 p.).
Buschow, S.I., Nolte-'t Hoen, E.N.M., van Niel, G., Pols, M.S., ten Broeke, A.G., Lauwen, M., Ossendorp, F., Melief, C.J.M., Raposo, G., Wubbolts, R.W., Wauben, M.H.M. & Stoorvogel, W. (2009). MHC II in dendritic cells is targeted to lysosomes or T Cell-Induced exosomes via distinct multivesicular body pathways. Traffic, 10, (pp. 1528-1542) (15 p.).
van Ham, S.M., Samsom, J.N., Bos, N.A., Damoiseaux, J., Laman, J.D. & Wauben, M.H.M. (2009). Vaccination immunology: Prevention and beyond NVVI-Dutch society for immunology course Lunteren. Immunology Letters, 122, (pp. 101-103) (3 p.).
  Articles - 2008
Nolte-'t Hoen, E.N.M., Boot, E.P.J., Wagenaar-Hilbers, J.P.A., van Bilsen, J.H.M., Arkesteijn, G., Storm, G., Everse, L.A., van Eden, W. & Wauben, M.H.M. (2008). Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134. Journal of Leukocyte Biology, 83 (1), (pp. 112-121) (10 p.).
Han, W.G., Unger, W.W.J. & Wauben, M.H.M. (2008). Identification of the immunodominant CTL epitope of EGFP in C57BL/6mice. Gene Therapy, 15 (9), (pp. 700-701) (2 p.).
  Articles - 2006
Hambach, L., Nijmeijer, B.A., Aghai, Z., Schie, M.L., Wauben, M.H.M., Falkenburg, J.H.F. & Goulmy, E. (2006). Human cytotoxic T lymphocytes specific for a single minor histocompatibility antigen HA-1 are effective against human lymphoblastic leukaemia in NOD/scid mice. Leukemia, 20, (pp. 371-374) (4 p.).
Kamphuis, S.S.M., Hfafnkelsdóttir, K., Klein, M., de Jager, W., Haverkamp, M.H., Bilsen, J., Albani, S., Kuis, W., Wauben, M.H.M. & Prakken, A.B.J. (2006). Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in health. Arthritis Research and Therapy, 8 (6), (pp. R178) (10 p.).
Koning, G.A., Schiffelers, R.M., Wauben, M.H.M., Kok, R.J., Mastrobattista, E., Molema, G., ten Hagen, T.L.M. & Storm, G. (2006). Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis. Arthritis and Rheumatism, 54, (pp. 1198-1208) (11 p.).
  Articles - 2005
Boot, E.P.J., Koning, G.A., Storm, G., Wagenaar-Hilbers, J.P.A., van Eden, W., Everse, L.A. & Wauben, M.H.M. (2005). CD134 as target for specific drug delivery to auto-aggressive CD4+ T cells in adjuvant arthritis. Arthritis Research and Therapy, 7, (pp. R604-R615) (12 p.).
Haan, E., Wagenaar-Hilbers, J.P.A., Liskamp, R.M.J., Moret, E.E. & Wauben, M.H.M. (2005). Limited plasticity in T cell recognition of modified T cell receptor contact residues in MHC class II bound peptides. Molecular Immunology, 42 (3), (pp. 355-364) (10 p.).
Haan, E., Moret, E.E., Wagenaar-Hilbers, J.P.A., Liskamp, R.M.J. & Wauben, M.H.M. (2005). Possibilities and limitations in the rational design of modified peptides for T cell mediated immunotherapy. Molecular Immunology, 42 (3), (pp. 365-373) (9 p.).
  Articles - 2004
't Hoen, E.N.M., Amoroso, M.G., Veenstra, J., Grosfeld-Stulemeyer, M.C., van Eden, W., Broeren, C.P.M. & Wauben, M.H.M. (2004). Effector and regulatory T cells derived from the same T cell clone differ in MHC class II-peptide multimer binding. European Journal of Immunology, 34, (pp. 1-11) (11 p.).
Nolte-'t Hoen, E.N.M., Wagenaar-Hilbers, J.P.A., Boot, E.P.J., Lin, C.H., Arkesteijn, G., van Eden, W., Taams, L.S. & Wauben, M.H.M. (2004). Identification of a CD4(+) CD25(+) T cell subset committed in suppress antigen-specific T cell responses without additional stimulation. European Journal of Immunology, 34 (11), (pp. 3016-3027) (12 p.).
Nolte - t Hoen, Esther N M, Wagenaar-Hilbers, Josée P A, Boot, Elmieke P J, Lin, Chia-Huey, Arkesteijn, Ger J A, van Eden, Willem, Taams, Leonie S & Wauben, Marca H M (2004). Identification of a CD4+CD25+ T cell subset committed in vivo to suppress antigen-specific T cell responses without additional stimulation. European Journal of Immunology, 34 (11), (pp. 3016-27) (12 p.).
Everse, L.A., Storm, G., Koning, G.A., Boot, E.P.J. & Wauben, M.H.M. (2004). Liposomal delivery of immunomodulatory peptides to antigen presenting cells. Immunobiology, 203, (pp. 353-354) (2 p.).
Metselaar, J.M., van der Berg, W.B., Holthuysen, A.E.M., Wauben, M.H.M., Storm, G. & van Lent, P.L.E.M. (2004). Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II. Annals of the Rheumatic Diseases, 63, (pp. 348-353) (6 p.).
Metselaar, J.M., van der Berg, W.B., Holthuysen, A.E.M., Wauben, M.H.M., Storm, G. & van Lent, P.L.E.M. (2004). Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis. Annals of the Rheumatic Diseases, 63, (pp. 348-353) (6 p.).
van Bilsen, J.H.M., Wagenaar, J.P.A., Grosfeld, M.J., van der Cammen, M.J.F., van Dijk, M.E.A., van Eden, W. & Wauben, M.H.M. (2004). Matrix metalloproteinases as targets for the immune system during experimental arthritis. Journal of Immunology, 172 (8), (pp. 5063-5068) (6 p.).
Haan, E., Wauben, M.H.M., Wagenaar-Hilbers, J.P.A., Grosfeld, M.C., Rijkers, D.T.S., Moret, E.E. & Liskamp, R.M.J. (2004). Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation-implications for immunological studies. Molecular Immunology, 40 (13), (pp. 943-948) (6 p.).
Nolte-'t Hoen, E.N.M., Wagenaar-Hilbers, J.P.A., Peters, P.J., Gadella, B.M. & Wauben, M.H.M. (2004). Uptake of membrane molecules from T cells endows antigen-presenting cells with novel functional properties. European Journal of Immunology, 34 (11), (pp. 3115-3125) (11 p.).
  Articles - 2003
Metselaar, J.M., Bruin, P., Boer, L.W., de Vringer, T., Snel, C.J., Oussoren, C., Wauben, M.H.M., Crommelin, D.J., Storm, G. & Hennink, W.E. (2003). A novel family of L-amino acid-based biodegradable polymer-lipid conjugates for the development of long-circulating liposomes with effective drug-targeting capacity. Bioconjugate Chemistry, 14 (6), (pp. 1156-1164) (9 p.).
Metselaar, J.M., Wauben, M.H.M., Wagenaar-Hilbers, J.P.A., Boerman, O.C. & Storm, G. (2003). Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulation liposomes. Arthritis and Rheumatism, 48 (7), (pp. 2059-2066) (8 p.).
Schmidt, J., Metselaar, J.M., Wauben, M.H.M., Toyka, K.V., Storm, G. & Gold, R. (2003). Drug targeting by long-circulation liposomal glucocorticosteriods increases therapeutic efficacy in a model of multiple sclerosis. Brain, 126 (8), (pp. 1895-904) (10 p.).
Prakken, A.B.J., Roord, S., Ronaghy, A., Wauben, M.H.M., Albani, S. & van Eden, W. (2003). Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis. Springer Seminars in Immunopathology, 25, (pp. 47-63) (17 p.).
ter Steege, J.C.A., Vianen, M.E., van Bilsen, J.H.M., Bijlsma, J.W.J., Lafeber, F.P.J.G. & Wauben, M.H.M. (2003). Identification of self-epitopes recognized by T cells in rheumatoid arthritis demonstrates matrix metalloproteinases as a novel T cell target. Journal of Rheumatology, 30 (6), (pp. 1147-1156) (10 p.).
  Articles - 2002
van der Laan, L.J., van der Goes, A., Wauben, M.H.M., Ruuls, S.R., Döpp, E.A., de Groot, C.J., Kuijpers, T.W., Elices, M.J. & Dijkstra, C.D. (2002). Beneficial effect of modified peptide inhibitor of alpha4 integrins on experimental allergic encephalomyelitis in Lewis rats. Journal of Neuroscience Research, 67 (2), (pp. 191-199) (9 p.).
van Halteren, A.G., Roep, B.O., Gregori, S., Cooke, A., van Eden, W., Kraal, G. & Wauben, M.H.M. (2002). Cross-reactive mycobacterial and self hsp60 epitope recognition in I-A(g7) expressing NOD, NOD-asp and Biozzi AB/H mice. Journal of Immunology, 18 (2), (pp. 139-147) (9 p.).
Janssen, E.M., Wauben, M.H.M., Nijkamp, F.P., van Eden, W. & van Oosterhout, A.J.M. (2002). Immunomodulatory effects of antigen-pulsed macrophages in a murine model of allergic asthma. American Journal of Respiratory Cell and Molecular Biology, 27 (2), (pp. 257-264) (8 p.).
Prakken, B., Roord, S., van Kooten, P., Wagenaar, J.P.A., van Eden, W., Albani, S. & Wauben, M.H.M. (2002). Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope. Arthritis and Rheumatism, 46 (7), (pp. 1937-1946) (10 p.).
Schmidt, J., Metselaar, J.M., Wauben, M.H.M., Storm, G., Toyka, K.V. & Gold, R. (2002). Liposomal prednisolone pulse therapy leads to in situ T-cell apoptosis and is beneficial in treatment of experimental autoimmune encephalomyelitis. Neurology, 58, (pp. A385-A385) (1 p.).
Koning, G.A., Wauben, M.H.M., ten Hagen, T.L.M., Everts, M., Kok, R.J., Schraa, A.J., Molema, G., Schiffelers, R.M. & Storm, G. (2002). Liposomes for drug targeting to endothelial cells at inflammatory sites. Endothelium: Journal of Endothelial Cell Research, 9, (pp. 129-127) (3 p.).
Metselaar, J.M., Wauben, M.H.M., Boerman, O.C., van Lent, P.L. & Storm, G. (2002). Long-circulating liposomes for i.v. targeted delivery of glucocorticoids in arthritis. Cellular and Molecular Biology Letters, 7 (2), (pp. 291-292) (2 p.).
de Haan, E.C., Wauben, M.H.M., Grosfeld-Stulemeyer, M.C., Kruijtzer, J.A.W., Liskamp, R.M.J. & Moret, E.E. (2002). Major histocompatibility complex class II binding characteristics of peptoid-peptide hybrids. Bioorganic and Medicinal Chemistry, 10, (pp. 1939-1945) (7 p.).
van Bilsen, J.H.M., Wagenaar-Hilbers, J.P.A., Boot, E.P.J., van Eden, W. & Wauben, M.H.M. (2002). Searching for the cartilage-associated mimicry epitope in adjuvant arthritis. Autoimmunity, 35 (3), (pp. 201-210) (10 p.).
van Bilsen, J.H.M., Wagenaar-Hilbers, J.P.A., van der Cammen, M.J.F., van Dijk, M.E., van Eden, W. & Wauben, M.H.M. (2002). Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration. Arthritis Research, 4 (4).
Offenhausser, M., Herr, A.S., Hartkamp, J., Wauben, M.H.M., Magnus, T., Grauer, O., Seubert, S., Weishaupt, A., Toyka, K.V., Gold, R. & Troppmair, J. (2002). Truncation of the neuritogenic peptide bP2(60-70) results in the generation of altered peptide ligands with the potential to interfere with T cell activation. Journal of Neuroimmunology, 129 (1-2), (pp. 97-105) (9 p.).
  Articles - 2001
Wauben, M.H.M. (2001). Gefascineerd door de januskop van de T-cel. Mediator, 12, (pp. 22-24) (3 p.).
van Bilsen, J.H.M., Wagenaar-Hilbers, J.P.A., van der Cammen, M.J.F., ter Steege, J.C.A., Grosfeld-Stulemeyer, M.C., van Eden, W., Lafeber, F.P.J.G. & Wauben, M.H.M. (2001). Motif-based identification of self-epitopes recognized by T cell in arthritis: a novel role for matrix metalloproteinases in arthritis. Nederlands Tijdschrift voor Reumatologie
de Haan, E.C., Wauben, M.H.M., Grosfeld-Stulemeyer, M.C. & Moret, E.E. (2001). Structure-based design and evaluation of MHC class II binding peptides. Biologicals, 29, (pp. 289-292) (4 p.).
  Articles - 2000
Taams, L.S. & Wauben, M.H.M. (2000). Anergic T cells as active regulators of the immune response. Human Immunology, 61 (7), (pp. 633-639) (7 p.).
Taams, L.S., Boot, E.P.J., van Eden, W. & Wauben, M.H.M. (2000). 'Anergic' T cells modulate the T-cell activating capacity of antigen-presenting cells. Journal of Autoimmunity, 14 (4), (pp. 335-341) (7 p.).
Prakken, B., Wauben, M.H.M., Genini, D., Samodal, R., Barnett, J., Mendivil, A., Leoni, L. & Albani, S. (2000). Artificial antigen-presenting cells as a tool to exploit the immune 'synapse'. Nature Medicine, 6 (12), (pp. 1406-1410) (5 p.).
Boot, E.P.J., Storm, G., Everse, L.A., Koning, G.A., Metselaar, J.M. & Wauben, M.H.M. (2000). CD134 as a target for activated auto-reactive T cells in arthritis. Immunobiology, 203, (pp. 349-350) (2 p.).
van Halteren, A.G.S., Roep, B.O., Mosselman, B., Gregori, S., Cooke, A., van Eden, W., Kraal, G. & Wauben, M.H.M. (2000). Cross-reactive HSP60 recognizing T cells in experimental diabetes. Immunobiology, 203, (pp. 532) (1 p.).
van Bilsen, J.H.M., Wagenaar-Hilbers, J.P.A., van der Cammen, M.J.F., ter Steege, J.C.A., Grosfeld-Stulemeyer, M.C., van Eden, W., Lafeber, F.P.J.G. & Wauben, M.H.M. (2000). Identification of autoantigens recognized by T cells in two experimental arthiritis models and in RA patients. Immunobiology, 203, (pp. 230) (1 p.).
Kamphuis, S.S.M., van Bilsen, J.H.M., Haverkamp, M, Gordon, G, Kuis, W., Wauben, M.H.M. & Prakken, A.B.J. (2000). Identification of joint inflammation-specific T cell responses in juvenile idiopathic arthritis: Potential targets for immunotherapy. Immunobiology, 203, (pp. 358-359) (2 p.).
Wauben, M.H.M. (2000). Immunological mechanisms involved in experimental peptide immunotherapy of T-cell-mediated diseases. Critical Reviews in Immunology, 20, (pp. 451-469) (19 p.).
van Rensen, A.J.M.L., Taams, L.S., Grosfeld-Stulemeyer, M.C., van Eden, W., Crommelin, D.J.A. & Wauben, M.H.M. (2000). Induction of T cell anergy by liposomes with incorporated major histocompatability complex (MHC) II/peptide complexes. Pharmaceutical Research, 17, (pp. 720-726) (7 p.).
de Haan, E.C., Wauben, M.H.M., Grosfeld-Stulemeyer, M.C., Kruijtzer, J.A.W., Liskamp, R.M.J. & Moret, E.E. (2000). MHC class II binding of peptoid-peptide hybrids. Immunobiology, 203, (pp. 30) (1 p.).
Janssen, E.M., van Oosterhout, A.J.M., van Rensen, A.J.M.L., van Eden, W., Nijkamp, F.P. & Wauben, M.H.M. (2000). Modulation of Th2 responses by peptide analogues in a murine model of allergic asthma: amelioration or deterioration of the disease process depends on the Th1 or Th2 skewing characteristics of the therapeutic peptide. Journal of Immunology, 164, (pp. 580-588) (9 p.).
van Tienhoven, E.A., Broeren, C.P.M., Noordzij, A., Wagenaar, J.P., van Eden, W. & Wauben, M.H.M. (2000). Nasal application of a naturally processed and presented T cell epitope derived from TCR AV11 protects against adjuvant arthritis. International Immunology, 12 (12), (pp. 1715-1721) (7 p.).
Haghparast, A., Wauben, M.H.M., Grosfeld-Stulemeyer, M.C., van Kooten, P. & Hensen, E.J. (2000). Selection of T-cell epitopes from foot-and-mouth disease virus reflects the binding affinity to different cattle MHC class II molecules. Immunogenetics, 51, (pp. 733-742) (10 p.).
't Hoen, E.N.M., Taams, L.S., van Eden, W. & Wauben, M.H.M. (2000). Sensitivity of antigen-presenting cells for modulation by > T cells. Immunobiology, 203, (pp. 200-201) (2 p.).
van Halteren, A.G.S., Mosselman, B., Roep, B.O., van Eden, W., Cooke, A., Kraal, G. & Wauben, M.H.M. (2000). T cell reactivity to heat shock protein 60 in diabetes-susceptible and genetically protected nonobese diabetic mice is associated with a protective cytokine profile. Journal of Immunology, 165, (pp. 5544-5551) (9 p.).
Janssen, E.M., van Oosterhout, A.J.M., Nijkamp, F.P., van Eden, W. & Wauben, M.H.M. (2000). The efficacy of immunotherapy in an experimental murine model of allergic asthma is related to the strength and site of T cell activation during immunotherapy. Journal of Immunology, 165, (pp. 7207-7214) (8 p.).
  Articles - 1999
Borghans, J.A.M., Taams, L.S., Wauben, M.H.M. & de Boer, R.J. (1999). Competition for antigenic sites during T cell proliferation: a mathematical interpretation of in vitro data. Proceedings of the National Academy of Sciences of the United States of America, 96, (pp. 10782-10787) (6 p.).
Crommelin, D.J.A., van Rensen, J.M.L., Wauben, M.H.M. & Storm, G. (1999). Liposomes in autoimmune diseases: selected applications in immunotherapy and inflammation detection. Journal of Controlled Release, 62, (pp. 245-251) (7 p.).
van Rensen, J.M.L., Wauben, M.H.M., Grosfeld-Stulemeyer, M.C., van Eden, W. & Crommelin, D.J.A. (1999). liposomes with incorporated MHC class II/peptide complexes as antigen presenting vesicles for specific T cell vaccines. Pharmaceutical Research, 16, (pp. 198-204) (7 p.).
Janssen, E.M., Wauben, M.H.M., Jonker, E.H., Hofman, G.A., van Eden, W., Nijkamp, F.P. & van Oosterhout, A.J.M. (1999). Opposite effects of immunotherapy with ovalbumin and the immunodominant T cell epitope on airway eosinophilia and hyperresponsiveness in a murine model of allergic asthma. American Journal of Respiratory and Critical Care Medicine, 21, (pp. 21-29) (9 p.).
  Articles - 1998
Taams, L.S., van Rensen, J.M.L., Poelen, M.C.M., van Els, C.A.C.M., Besseling, A., Wagenaar, J.P.A., van Eden, W. & Wauben, M.H.M. (1998). Anergic T cells actively suppress T cell responses via the antigen presenting cel. European Journal of Immunology, 28, (pp. 2902-2912) (11 p.).
van Eden, W., van der Zee, R., Paul, A.G.A., Prakken, A.B.J., Wendling, S.M., Anderton, S.M. & Wauben, M.H.M. (1998). Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases?. Immunology Today, 19, (pp. 303) (1 p.).
van Eden, W., van der Zee, R., Taams, L.S., Prakken, A.B.J., van Roon, J.A.G. & Wauben, M.H.M. (1998). Heat-shock protein T-cell epitopes trigger a spreading regulatory control in a diversified arthritogenic T-cell response. Immunological Reviews, 164, (pp. 169-173) (5 p.).
Prakken, A.B.J., Wauben, M.H.M., van Kooten, P., Anderton, S.M., van der Zee, R., Kuis, W. & van Eden, W. (1998). Nasal administration of arthritis-related T cell epitopes of heat shock protein 60 as a promising way for immunotherapy in chronic arthritis. Biotherapy, 10, (pp. 205) (1 p.).
  Articles - 1996
Eden, Willem, Anderton, Stephen M, Zee, Ruurd, Prakken, Berent J, Broeren, Chris PM, Wauben, Marca HM & van der Zee, Ruurd (1996). (Altered) Self Peptides and the Regulation of Self Reactivity in the Peripheral T cell Pool. Immunological Reviews, 149 (1), (pp. 55-73) (19 p.).
  Articles - 1994
Janssen, Riny, Wauben, Marca, van der Zee, Ruurd & Tommassen, Jan (1994). Immunogenicity of a mycobacterial T-cell epitope expressed in outer membrane protein PhoE of Escherichia coli. Vaccine, 12 (5), (pp. 406-409) (4 p.).
Janssen, Riny, Wauben, Marca, der Zee, Ruurd van, de Gast, Manja & Tommassen, Jan (1994). Influence of amino acids of a carrier protein flanking an inserted T cell determinant on T cell stimulation. International Immunology, 6 (8), (pp. 1187) (1 p.).
  Book parts / chapters - 2006
Wauben, M.H.M. (2006). Intercellular Communication via Protein Transfer. In Lutz, M.B., Romani, N. & Steinkasserer, A. (Eds.), Handbook of Dendritic Cells: Biology, Diseases and Therapies. Weinheim: Wiley.
  Awards - 0
M.H.M. Wauben () Additional funding for clinical study STW-Danone partnership 70kEuro
M.H.M. Wauben () Additional Funding STW -Danonepartnership 30kEuro
M.H.M. Wauben () Becton Dickinson, Collaborative Research Agreement 500kEuro (in kind)
M.H.M. Wauben () Best poster award at annual conference of the Dutch Society for Immunology
M.H.M. Wauben () BioVacSafe WP7 pilot study proposal 56kEuro
M.H.M. Wauben () FACS from BD (500K, in kind)
M.H.M. Wauben () Genmab, Sponsored Research Agreement 107kEuro
M.H.M. Wauben () Genmab, Sponsored Research Agreement 107kEuro
M.H.M. Wauben () Go with the flow cytometer: Characterization of T cell exosomes secreted during DC - T cell interactions.
M.H.M. Wauben () Regulated exosome secretion and transfer during cognate DC-Tcell interaction.
M.H.M. Wauben () Winner
  Lectures - 2013
M.H.M. Wauben (04.03.2013) Extracellular vesicles: From trash to cash.
M.H.M. Wauben (04.03.2013) High resolution flow cytometry for the analysis of individual nano-sized vesicles
M.H.M. Wauben (18.04.2013) How swarm detection influences quantitative and qualitative flow cytometric analysis of nano-sized vesicles
M.H.M. Wauben (25.04.2013) Ignored, trashed & rediscovered: immune regulation via cell-derived vesicles
M.H.M. Wauben (12.03.2013) Immune cell-derived vesicles: Tiny messengers with great potential
M.H.M. Wauben (27.03.2013) Immune cell-derived vesicles: Tiny messengers with great potential
M.H.M. Wauben (15.01.2013) Immune cell-derived vesicles: Tiny messengers with great potential.
M.H.M. Wauben (19.12.2013) Intercellular communication in the immune system: Unlocking the mysteries of extracellular vesicles (Educational track).
M.H.M. Wauben (17.05.2013) Needs for clinical implementation of extracellular vesicles
M.H.M. Wauben (19.09.2013) Possibilities & limitations for the analysis of nano-sized cell-derived vesicles
M.H.M. Wauben (04.10.2013) Single extracellular vesicle and swarm detection by flow cytometry
M.H.M. Wauben (20.04.2013) Wrap-up of basic science
  Lectures - 2012
M.H.M. Wauben (19.09.2012) Dialoog met de kleine dingen van het leven
M.H.M. Wauben (11.01.2012) Exosomes in intercellular communication
M.H.M. Wauben (18.04.2012) High resolution flow cytometry-based multiparameter analysis of nanosized cell-derived vesicles.
M.H.M. Wauben (24.10.2012) Immune Cell-Derived Vesicles (Exosomes Carrying RNA): Tiny Messengers With Great Potential.
M.H.M. Wauben (12.07.2012) Immune cell-derived vesicles: small messengers with great potential.
M.H.M. Wauben (30.10.2012) IMMUNE CELL-DERIVED VESICLES: Tiny messengers with great potential.
M.H.M. Wauben (10.03.2012) The quantity and quality of membrane vesicles released by dendritic cells and T cells is regulated by (co-)stimulatory cues.
  Lectures - 2011
M.H.M. Wauben (14.03.2011) Exosome secretion during DC-T cell interactions
M.H.M. Wauben (19.01.2011) Quantitative and qualitative flow cytometric analysis of exosomes at the particle level
  Lectures - 2010
M.H.M. Wauben (07.09.2010) Exosomal communication between dendritic cells and T-cells
M.H.M. Wauben (19.07.2010) Exosomal communication during dendrtic cell-T-cell interactions
M.H.M. Wauben (06.01.2010) Exosomes in immunology
M.H.M. Wauben (20.04.2010) Qualitative and Quantitative analysis of exosomes
  Lectures - 2009
M.H.M. Wauben (27.01.2009) Activated T-cells recruit secreted dendritic cell-derived exosomes via LFA-1.
M.H.M. Wauben (08.01.2009) Intercellular communication via exosomes
  Lectures - 2008
M.H.M. Wauben (22.09.2008) Exosomal communication in the Immune System.
M.H.M. Wauben (22.08.2008) Exosome research in Utrecht.
  Lectures - 2006
M.H.M. Wauben (08.09.2006) 16th European Congress of Immunology
M.H.M. Wauben (08.12.2006) Annual meeting of the Dutch Society for Immunology
M.H.M. Wauben (11.05.2006) Society for Immunology regional Group meeting on causes and treatment of autoimmune diseases (50th Anniversary of the BSI)
  Television or radio appearances - 0
M.H.M. Wauben () Dialoog met de kleine dingen van het leven ??
M.H.M. Wauben () Film portrait
  Websites / portals - 2012
  Editorial activity - 0
M.H.M. Wauben () Journal of Extracellular Vesicles
  Contribution to the work of national or international committees and working groups - 0
M.H.M. Wauben () Associate editor
M.H.M. Wauben () Board member.
M.H.M. Wauben () Chairperson at the Second International Conference of International Society of Extracellular Vesicles (ISEV), April 2013, Boston, USA
M.H.M. Wauben () Chairperson of the Education Committee of the Dutch Society of Immunology
M.H.M. Wauben () Congres Organisatie Lunteren-Meeting 2-3 april 2009
M.H.M. Wauben () Congres organisatie Lunteren-Meeting van de NVVI op 3 en 4 april 2008
M.H.M. Wauben () Executive Board member
M.H.M. Wauben () Executive board member.
M.H.M. Wauben () Founding member
M.H.M. Wauben () Initiator and Organiser of the Utrecht exosome minisymposium/workshop at the Fac. Veterinary Medicine
M.H.M. Wauben () Invited Chairperson voor de Lymfocyten sessie op het Jaarcongres van de NVVI
M.H.M. Wauben () Lid van de Wetenschappelijke Adviesraad type 1 Diabetes
M.H.M. Wauben () Lid Wetenschappelijke adviesraad type 1 Diabetes
M.H.M. Wauben () Management committee
M.H.M. Wauben () Member
M.H.M. Wauben () Member
M.H.M. Wauben () Member of the advisory commitee Type I Diabetes
M.H.M. Wauben () Member of the advisory committee Type I Diabetes
M.H.M. Wauben () Member of the Board of Examiners Life Sciences
M.H.M. Wauben () Member of the interim board
M.H.M. Wauben () Member of the Master Exam Committee
M.H.M. Wauben () Moderator of the meet-the-expert masterclass J. Samson, I&I PhD program (February 11), UMCU
M.H.M. Wauben () Moderator round table discussions
M.H.M. Wauben () Moderator round table discussions ISEV scientific research seminar on isolation and characterization of extracellular vesicles, Budapest, Hungary, October 2013
M.H.M. Wauben () National management board member EU COST Action at BM1202 European Network on Microvesicles and Exosomes in Health and Disease (2012)
M.H.M. Wauben () Organisatie Eijkman School Science meeting "Basic aspects of antigen processing, presentation and recognition"
M.H.M. Wauben () Organisatie jaarlijkse Lunteren-meeting van de Nederlandse Vereniging voor Immunologie
M.H.M. Wauben () Organisation annual Lunteren Meeting of the Dutch Society of Immunology
M.H.M. Wauben () Organiser of the Third International Conference of International Society of Extracellular Vesicles (ISEV), Rotterdam, The Netherlands, April 2014
M.H.M. Wauben () Organizer
M.H.M. Wauben () Organizer
M.H.M. Wauben () Organizer at the Utrecht University Life Sciences day; Extracellular vesicles in health & disease, Utrecht, Netherlands, March 2013
M.H.M. Wauben () Organizer of the Second International Conference of ISEV, in Boston, USA, April 2013
M.H.M. Wauben () Trainer Functie bij: Trainingschool of EU COST Action at BM1202 European Network on Microvesicles and Exosomes in Health and Disease (2012), Valencia, Spain
M.H.M. Wauben () Vice-Chair
M.H.M. Wauben () Vice-Chair EU COST Action at BM1202 European Network on Microvesicles and Exosomes in Health and Disease (2013).
M.H.M. Wauben () Voorzitter van de auto-immuunziekten sessie op het jaarcongres van de Nederlandse Vereniging voor Immunologie
M.H.M. Wauben () Voorzitter van de cursuscommissie
M.H.M. Wauben () Voorzitter van de Cursuscommissie NVVI
M.H.M. Wauben () Voorzitter van de cursuscommissie van de Nederlandse Vereniging voor Immunologie
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Gegenereerd op 2017-10-17 16:44:53
Additional functions and activities
Gegenereerd op 2017-10-17 16:44:53
Full name
prof. dr. M.H.M. Wauben Contact details
Nieuw Gildestein

Yalelaan 2
Room 204
3584 CM  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 5451
Phone number (department) +31 30 253 5389
Nieuw Gildestein

Bolognalaan 50 / Yalelaan 2 50
Room 243
3584 CJ  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 5451
Phone number (department) +31 30 253 5389
Postal address
Postbus 80.176
3508 TD    UTRECHT
The Netherlands
Gegenereerd op 2017-10-17 16:44:53
Last updated 08.09.2014