Publications
2025
Scholarly publications
Qiu, B., Pompe, S., Xenaki, K. T., di Maggio, A., van Bergen En Henegouwen, P. M. P., Oliveira, S., Mastrobattista, E., & Caiazzo, M. (2025). Generation of a perfusable three-dimensional human neurovascular chip to model brain drug delivery and immune cell extravasation. Journal of controlled release : official journal of the Controlled Release Society, 387, 114257. Advance online publication. [DOI]
Öktem, M., Nguyen, T. H., Bosman, E. D. C., Fens, M. H. A. M., Caiazzo, M., Mastrobattista, E., Lei, Z., & de Jong, O. G. (2025). Lipopeptide-mediated delivery of CRISPR/Cas9 ribonucleoprotein complexes for gene editing and correction. Journal of controlled release : official journal of the Controlled Release Society, 383, Article 113854. [DOI] [Portal]
Redi, G., Del Piano, F., Cappellini, S., Paladino, M., den Breejen, A., Fens, M. H. A. M., & Caiazzo, M. (2025). Delivery Systems in Neuronal Direct Cell Reprogramming. Cellular Reprogramming, 27(3), 109-123. [DOI]
Qiu, B., Pompe, S., Xenaki, K. T., Di Maggio, A., Moreno, C. B., van Bergen En Henegouwen, P. M. P., Mastrobattista, E., Oliveira, S., & Caiazzo, M. (2025). Receptor-mediated transcytosis of nanobodies targeting the heparin-binding EGF-like growth factor in human blood-brain barrier models. Journal of controlled release : official journal of the Controlled Release Society, 383, Article 113852. [DOI] [Portal]
2024
Scholarly publications
2023
Scholarly publications
Pulcrano, S., De Gregorio, R., De Sanctis, C., Volpicelli, F., Piscitelli, R. M., Speranza, L., Perrone-Capano, C., di Porzio, U., Caiazzo, M., Martini, A., Giacomet, C., Medina, D., Awatramani, R., Viggiano, D., Federici, M., Mercuri, N. B., Guatteo, E., & Bellenchi, G. C. (2023). miR-218 promotes dopaminergic differentiation and controls neuron excitability and neurotransmitter release through the regulation of a synaptic-related genes network. Journal of Neuroscience, 43(48), 8104-8125. [DOI] [Repository]
van Vliet, E. F., Knol, M. J., Schiffelers, R. M., Caiazzo, M., & Fens, M. H. A. M. (2023). Levodopa-loaded nanoparticles for the treatment of Parkinson's disease. Journal of controlled release : official journal of the Controlled Release Society, 360, 212-224. [DOI] [Repository]
Douka, S., Brandenburg, L. E., Casadidio, C., Walther, J., Garcia, B. B. M., Spanholtz, J., Raimo, M., Hennink, W. E., Mastrobattista, E., & Caiazzo, M. (2023). Lipid nanoparticle-mediated messenger RNA delivery for ex vivo engineering of natural killer cells. Journal of controlled release : official journal of the Controlled Release Society, 361, 455-469. [DOI] [Repository]
Ribezzi, D., Gueye, M., Florczak, S., Dusi, F., de Vos, D., Manente, F., Hierholzer, A., Fussenegger, M., Caiazzo, M., Blunk, T., Malda, J., & Levato, R. (2023). Shaping Synthetic Multicellular and Complex Multimaterial Tissues via Embedded Extrusion-Volumetric Printing of Microgels. Advanced Materials, 35(36), Article 2301673. [DOI] [Repository]
2022
Scholarly publications
Aversano, S., Caiazza, C., & Caiazzo, M. (2022). Induced pluripotent stem cell-derived and directly reprogrammed neurons to study neurodegenerative diseases: The impact of aging signatures. Frontiers in Aging Neuroscience, 14, Article 1069482. [DOI] [Repository]
Aversano, S., Palladino, R., & Caiazzo, M. (2022). Direct Cell Conversion of Somatic Cells into Dopamine Neurons: Achievements and Perspectives. Cellular Reprogramming, 24(5), 259-270. [DOI] [Repository]
Pulcrano, S., De Gregorio, R., De Sanctis, C., Lahti, L., Perrone-Capano, C., Ponti, D., Di Porzio, U., Perlmann, T., Caiazzo, M., Volpicelli, F., & Bellenchi, G. C. (2022). Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation. International Journal of Molecular Sciences, 23(13), 1-18. Article 6961. [DOI] [Repository]
Pascale, E., Caiazza, C., Paladino, M., Parisi, S., Passaro, F., & Caiazzo, M. (2022). MicroRNA Roles in Cell Reprogramming Mechanisms. Cells, 11(6), Article 940. [DOI] [Repository]
2021
Scholarly publications
Caiazza, C., Parisi, S., & Caiazzo, M. (2021). Liver organoids: Updates on disease modeling and biomedical applications. Biology, 10(9), 1-13. Article 835. [DOI] [Repository]
Jalink, P., & Caiazzo, M. (2021). Brain Organoids: Filling the Need for a Human Model of Neurological Disorder. Biology, 10(8), 1-23. Article 740. [DOI] [Repository]
Qiu, B., de Vries, R. J., & Caiazzo, M. (2021). Direct Cell Reprogramming of Mouse Fibroblasts into Functional Astrocytes Using Lentiviral Overexpression of the Transcription Factors NFIA, NFIB, and SOX9. In H. Ahlenius (Ed.), Neural Reprogramming: Methods and Protocols (Vol. 2352, pp. 31-43). (Methods in Molecular Biology; Vol. 2352). Springer. [DOI] [Repository]
2020
Scholarly publications
Pascale, E., Divisato, G., Palladino, R., Auriemma, M., Ngalya, E. F., & Caiazzo, M. (2020). Noncoding rnas and midbrain da neurons: Novel molecular mechanisms and therapeutic targets in health and disease. Biomolecules, 10(9), Article 1269. [DOI] [Repository]
Rendina, A., Drongitis, D., Donizetti, A., Fucci, L., Milan, G., Tripodi, F., Giustezza, F., Postiglione, A., Pappatà, S., Ferrari, R., Bossù, P., Angiolillo, A., di Costanzo, A., Caiazzo, M., & Vitale, E. (2020). CD33 and SIGLECL1 Immunoglobulin Superfamily Involved in Dementia. Journal of Neuropathology and Experimental Neurology, 79(8), 891-901. [DOI] [Repository]
Ye, S., Boeter, J. W. B., Mihajlovic, M., van Steenbeek, F. G., van Wolferen, M. E., Oosterhoff, L. A., Marsee, A., Caiazzo, M., van der Laan, L. J. W., Penning, L. C., Vermonden, T., Spee, B., & Schneeberger, K. (2020). A Chemically Defined Hydrogel for Human Liver Organoid Culture. Advanced Functional Materials, 30(48), Article 2000893. [DOI] [Repository]
Qiu, B., Bessler, N., Figler, K., Buchholz, M. B., Rios, A. C., Malda, J., Levato, R., & Caiazzo, M. (2020). Bioprinting Neural Systems to Model Central Nervous System Diseases. Advanced Functional Materials, 30(44), Article 1910250. [DOI] [Repository]
Della Valle, F., Thimma, M. P., Caiazzo, M., Pulcrano, S., Celii, M., Adroub, S. A., Liu, P., Alanis-Lobato, G., Broccoli, V., & Orlando, V. (2020). Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements. Stem Cell Reports, 14(1), 60-74. [DOI] [Repository]
2019
Scholarly publications
Giorgio, E., Lorenzati, M., Rivetti di Val Cervo, P., Brussino, A., Cernigoj, M., Della Sala, E., Bartoletti Stella, A., Ferrero, M., Caiazzo, M., Capellari, S., Cortelli, P., Conti, L., Cattaneo, E., Buffo, A., & Brusco, A. (2019). Allele-specific silencing as treatment for gene duplication disorders: proof-of-principle in autosomal dominant leukodystrophy. Brain, 142(7), 1905–1920. [DOI] [Repository]
2018
Scholarly publications
Barbagiovanni, G., Germain, P. L., Zech, M., Atashpaz, S., Lo Riso, P., D'Antonio-Chronowska, A., Tenderini, E., Caiazzo, M., Boesch, S., Jech, R., Haslinger, B., Broccoli, V., Stewart, A. F., Winkelmann, J., & Testa, G. (2018). KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes. Cell Reports, 25(4), 988-1001. [DOI] [Repository]
Man, J. H. K., Groenink, L., & Caiazzo, M. (2018). Cell reprogramming approaches in gene- and cell-based therapies for Parkinson's disease. Journal of Controlled Release, 286, 114-124. [DOI] [Repository]
De Gregorio, R., Pulcrano, S., De Sanctis, C., Volpicelli, F., Guatteo, E., von Oerthel, L., Latagliata, E. C., Esposito, R., Piscitelli, R. M., Perrone-Capano, C., Costa, V., Greco, D., Puglisi-Allegra, S., Smidt, M. P., di Porzio, U., Caiazzo, M., Mercuri, N. B., Li, M., & Bellenchi, G. C. (2018). MiR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation. Stem Cell Reports, 10, 1-14. [DOI] [Repository]
2017
Scholarly publications
2016
Scholarly publications
Caiazzo, M., Okawa, Y., Ranga, A., Piersigilli, A., Tabata, Y., & Lutolf, M. P. (2016). Defined three-dimensional microenvironments boost induction of pluripotency. Nature Materials, 15(3), 344-352. [DOI]
Ranga, A., Girgin, M., Meinhardt, A., Eberle, D., Caiazzo, M., Tanaka, E. M., & Lutolf, M. P. (2016). Neural tube morphogenesis in synthetic 3D microenvironments. Proceedings of the National Academy of Sciences of the United States of America, 113(44), E6831-E6839. [DOI] [Repository]
2015
Scholarly publications
Colasante, G., Lignani, G., Rubio, A., Medrihan, L., Yekhlef, L., Sessa, A., Massimino, L., Giannelli, S. G., Sacchetti, S., Caiazzo, M., Leo, D., Alexopoulou, D., Dell'Anno, M. T., Ciabatti, E., Orlando, M., Studer, M., Dahl, A., Gainetdinov, R. R., Taverna, S., ... Broccoli, V. (2015). Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming. Cell Stem Cell, 17(6), 719-734. [DOI]
Caiazzo, M., Giannelli, S., Valente, P., Lignani, G., Carissimo, A., Sessa, A., Colasante, G., Bartolomeo, R., Massimino, L., Ferroni, S., Settembre, C., Benfenati, F., & Broccoli, V. (2015). Direct conversion of fibroblasts into functional astrocytes by defined transcription factors. Stem Cell Reports, 4(1), 25-36. [DOI]
2014
Scholarly publications
Dell'Anno, M. T., Caiazzo, M., Leo, D., Dvoretskova, E., Medrihan, L., Colasante, G., Giannelli, S., Theka, I., Russo, G., Mus, L., Pezzoli, G., Gainetdinov, R. R., Benfenati, F., Taverna, S., Dityatev, A., & Broccoli, V. (2014). Remote control of induced dopaminergic neurons in parkinsonian rats. Journal of Clinical Investigation, 124(7), 3215-29. [DOI]
Volpicelli, F., Caiazzo, M., Moncharmont, B., di Porzio, U., & Colucci-D'Amato, L. (2014). Neuronal differentiation dictates estrogen-dependent survival and ERK1/2 kinetic by means of caveolin-1. PLoS One, 9(10). [DOI]
2013
Scholarly publications
Theka, I., Caiazzo, M., Dvoretskova, E., Leo, D., Ungaro, F., Curreli, S., Managò, F., Dell'Anno, M. T., Pezzoli, G., Gainetdinov, R. R., Dityatev, A., & Broccoli, V. (2013). Rapid generation of functional dopaminergic neurons from human induced pluripotent stem cells through a single-step procedure using cell lineage transcription factors. Stem cells translational medicine, 2(6), 473-9. [DOI]
Broccoli, V., & Caiazzo, M. (2013). Nuclear receptors: Oxysterols detour to neurodevelopment. Nature Chemical Biology, 9(2), 70-71. [DOI]
2012
Scholarly publications
Broccoli, V., Caiazzo, M., Dell'Anno, M. T., de Leo, D., Gainetdinov, R. R., Pezzoli, G., & Dityatev, A. (2012). Somatic cell reprogramming into dopaminergic neurons for Parkinson's disease therapy. Journal of Neurology, 259(1), 5-6. [DOI]
Caiazzo, M. (2012). Alternative sources of dopaminergic neurons for cell replacement therapy in Parkinson's disease. Clinical Neuropathology, 31(3), 167-168.
2011
Scholarly publications
Caiazzo, M., Dell'Anno, M. T., Dvoretskova, E., Lazarevic, D., Taverna, S., Leo, D., Sotnikova, T. D., Menegon, A., Roncaglia, P., Colciago, G., Russo, G., Carninci, P., Pezzoli, G., Gainetdinov, R. R., Gustincich, S., Dityatev, A., & Broccoli, V. (2011). Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature, 476(7359), 224-7. [DOI]
Broccoli, V., Caiazzo, M., & Dell'Anno, M. T. (2011). Setting a highway for converting skin into neurons. Journal of Molecular Cell Biology, 3(6), 322-323. [DOI]
Caiazzo, M., Colucci-D'Amato, L., Volpicelli, F., Speranza, L., Petrone, C., Pastore, L., Stifani, S., Ramirez, F., Bellenchi, G. C., & di Porzio, U. (2011). Krüppel-like factor 7 is required for olfactory bulb dopaminergic neuron development. Experimental Cell Research, 317(4), 464-473. [DOI]
2010
Scholarly publications
Caiazzo, M., Colucci-D'Amato, L., Esposito, M. T., Parisi, S., Stifani, S., Ramirez, F., & di Porzio, U. (2010). Transcription factor KLF7 regulates differentiation of neuroectodermal and mesodermal cell lineages. Experimental Cell Research, 316(14), 2365-2376. [DOI]
2007
Scholarly publications
Volpicelli, F., Caiazzo, M., Greco, D., Consales, C., Leone, L., Perrone-Capano, C., D'Amato, L. C., & di Porzio, U. (2007). Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro. Journal of Neurochemistry, 102(2), 441-453. [DOI]
2004
Scholarly publications
Volpicelli, F., Consales, C., Caiazzo, M., Colucci-D'Amato, L., Perrone-Capano, C., & di Porzio, U. (2004). Enhancement of dopaminergic differentiation in proliferating midbrain neuroblasts by sonic hedgehog and ascorbic acid. Neural Plasticity, 11(1-2), 45-57. [DOI]