prof. dr. M. (Marc) Baldus
Gegenereerd op 2018-09-22 08:10:03

Structural Biology / NMR Spectroscopy
  • NMR is a non-invasive method that can provide structural information at the most detailed level in heterogeneous molecular systems
  • Our group develops and applies solid-state NMR methods that maximize spectroscopic sensitivity and allow for the analysis of such complex systems
  • By combining NMR with biochemical and biophysical approaches we aim at studying molecular structure and function in-situ and at atomic resolution
  • Applications range from drug carriers to large protein machines that execute their function when associated with specific cell compartments.

Our research is funded by National and international Research grants and has been awarded by international prizes, for example by  the Association of the European Biophysical Societies or by the International Council on Magnetic Resonance in Biological Systems (ICMRBS).

Involved in the following study programme(s)

Cover of our review article in Angewandte Chem. Int. Ed.
Gegenereerd op 2018-09-22 08:10:03
Curriculum vitae Download PDF

Academic background

Since 4/2016 Scientific Director, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht/The Netherlands.
Since 3/2010 Head, Section NMR, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht/The Netherlands.
Since 8/2008 Full Professor of Structural Biology, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht/The Netherlands.
2000/2008 Group leader (C3 / Associate Professor), Max-Planck-Institute for Biophysical Chemistry, Goettingen/Germany.
1999/2000 University Lecturer, Leiden Institute of Chemistry, Leiden University, Leiden/The Netherlands.
1997/1999 Postdoctoral research associate, MIT/Harvard Center of Magnetic Resonance, Massachusetts Institute of Technology, Cambridge/USA.
1994/1997 Ph.D./Postdoc studies, NSR Center of Molecular Structure, Design and Synthesis, University of Nijmegen, Nijmegen, The Netherlands.
1991/1996 Ph.D. student, Laboratory of Physical Chemistry, ETH Zentrum, Zurich/Switzerland. Research group of R.R. Ernst and B.H. Meier.
1991 Summer student, Princeton Lectures on biophysics, Princeton University, Princeton/USA.
1990/1991 Research Assistant and Diploma Student, Department of Physics, University of Florida, Gainesville/USA.
1986/1991 Study of Physics, TU Darmstadt, Darmstadt/Germany.

Co-organizer international meeting on "Hyperpolarized Magnetic Resonance", Egmond aan Zee, 2015
Member of ERC Consolidator Grant Panel 2013-2017
Member of the Managing board of the Bijvoet Center for Biomolecular Research, UU
Member of ERC and VIDI advisory commissions (Life science), UU
2010-2015 Member and Chair, research advisory commission, Department of Chemistry, UU
Member of the 2015 VIDI review panel (NWO-CW)
Member of the Scientific Advisory Board in Chemistry, Lorentz Center, Leiden.
Chairman & Member of the Scientific Advisory Board, 2015 PAC meeting of the Society of Dutch Chemistry students, Amsterdam.
Co-organizer of the 2013 Keystone symposium on "NMR in Biology".
Member, ICMRBS (International Council on Magnetic Resonance in Biological Systems) Founders Medal Selection Committee 2012.
Organizer of the 2011 Annual Meeting of the ITN on Structural Biology of Membrane Proteins, Soesterberg, NL.
Member of the Scientific Committee of the 2011 Euromar conference.
Member, Editorial Board, Biophysical Journal, 2008-2011.
Member, International Advisory Panel, 850 MHz UK solid-state NMR facility
Member, Scientific committee, 6th Alpine conference on solid-state NMR, 2009, Chamonix, France
Member, ICMRBS (International Council on Magnetic Resonance in Biological Systems) Founders Medal Selection Committee 2010.
Member of the Executive Committee of the Experimental NMR Conference (ENC), 2007-2013, USA
Member of the RCSB (PDB-BMRB) Task Group on NMR
Member of the executive committee, GdCh subgroup Magnetic Resonance Spectroscopy, 2005-2008
Chairperson (with C. Griesinger),29th GdCh Annual Meeting, MR Division, Magnetic Resonance in Biophysical Chemistry, Goettingen 2007
Chairperson Germany (with L. Frydman,Minerva-Gentner Symposium on Methodological Frontiers in Magnetic Resonance, Eilat 2005
Coorganizer, Ph.D. Seminar Series, MPI for Biophysical Chemistry, 2000-2008

Stipends, Awards and Selected Grants
2015 NWO TOP-PUNT grant (with A. Bonvin)
2015 iNEXT, H2020 Infrastructure project.(with UU, NKI and international partners)
2014 Günther Laukien Prize awarded at the 55th ENC conference, Boston
2012 NWO National Roadmap for Large-Scale Research Facilities grant (as coordinator of the national uNMR-NL consortium)
2011 NWO Vici grant
2010 NWO groot grant
2009 NWO middlegroot grant
2008 NWO Startup subsidy
2007 EBSA Prize of the Association of the European Biophysical Societies, awarded at the 6th EBSA conference, London
2006 Recipient of the Founders Medal of the International Council on Magnetic Resonance in Biological Systems (ICMRBS) awarded at 22nd ICMRBS conference, Gottingen.
1997 Postdoctoral Research stipend of the DFG
1997 Stipend of the Alexander-von-Humboldt Foundation
1996 Ph.D. award, 18th GDCh-Fachgruppen Tagung NMR, Eichstaett, Germany
1992-94 Ph.D. research fellow of the Swiss Chemical Industry
1991 NEC travel Stipend, "Princeton Lectures on Biophysics"
1990 Graduate Research Assistantship DSRB Award, University of Florida

AMPERE, KNCV, Biophysical Society


Gegenereerd op 2018-09-22 08:10:03

For updated lists, please see:

 Google Scholar Citations &

Research ID: C-2737-2009

All publications
  2018 - Scholarly publications
Chowdhury, Abhishek Dutta, Paioni, Alessandra Lucini, Houben, Klaartje, Whiting, Gareth T., Baldus, Marc & Weckhuysen, Bert M. (02.07.2018). Bridging the Gap between the Direct and Hydrocarbon Pool Mechanisms of the Methanol-to-Hydrocarbons Process. Angewandte Chemie-International Edition, 57 (27), (pp. 8095-8099).
Baker, Lindsay A., Sinnige, Tessa, Schellenberger, Pascale, De Keyzer, Jeanine, Siebert, C. Alistair, Driessen, Arnold J. M., Baldus, Marc & Grünewald, Kay (02.01.2018). Combined 1 H-Detected Solid-State NMR Spectroscopy and Electron Cryotomography to Study Membrane Proteins across Resolutions in Native Environments. Structure with Folding & design, 26 (1), (pp. 161-170.e3) (10 p.).
Chowdhury, Abhishek Dutta, Houben, Klaartje, Whiting, Gareth T., Chung, Sangho, Baldus, Marc & Weckhuysen, Bert M. (01.01.2018). Electrophilic aromatic substitution over zeolites generates Wheland-type reaction intermediates. Nature Catalysis, 1 (1), (pp. 23-31).
Narasimhan, Siddarth, Mance, Deni, de Agrela Pinto, Cecilia, Weingarth, Markus, Bonvin, Alexandre M.J.J. & Baldus, Marc (2018). Rapid prediction of multi-dimensional NMR data sets using FANDAS. In Ranajeet Ghose (Eds.), Protein NMR - Methods and Protocols (pp. 111-132) (22 p.). New York: Humana Press.
Vollmer, Ina, Li, Guanna, Yarulina, Irina, Kosinov, Nikolay, Hensen, Emiel J M, Houben, Klaartje, Mance, Deni, Baldus, Marc, Gascon, Jorge & Kapteijn, Frederik (2018). Relevance of the Mo-precursor State in H-ZSM-5 for the Methane Dehydroaromatization. Catalysis Science and Technology (3).
  2017 - Scholarly publications
Mance, Deni, van der Zwan, Johan, Velthoen, Marjolein E Z, Meirer, Florian, Weckhuysen, Bert M, Baldus, Marc & Vogt, Eelco T C (11.04.2017). A DNP-supported solid-state NMR study of carbon species in fluid catalytic cracking catalysts. Chemical Communications, 53 (28), (pp. 3933 - 3936) (4 p.).
Atherton, Joseph, Jiang, Kai, Stangier, Marcel M, Luo, Yanzhang, Hua, Shasha, Houben, Klaartje, van Hooff, Jolien J E, Joseph, Agnel-Praveen, Scarabelli, Guido, Grant, Barry J, Roberts, Anthony J, Topf, Maya, Steinmetz, Michel O., Baldus, Marc, Moores, Carolyn A & Akhmanova, Anna (2017). A structural model for microtubule minus-end recognition and protection by CAMSAP proteins. Nature Structural and Molecular Biology, 24 (11), (pp. 931-943).
Gast, P, Mance, D, Zurlo, E, Ivanov, K L, Baldus, M & Huber, M (07.02.2017). A tailored multi-frequency EPR approach to accurately determine the magnetic resonance parameters of dynamic nuclear polarization agents - application to AMUPol. Physical Chemistry Chemical Physics, 2017 (19), (pp. 3777-3781) (5 p.).
Pellach, Michal, Mondal, Sudipta, Harlos, Karl, Mance, Deni, Baldus, Marc, Gazit, Ehud & Shimon, Linda J. W. (13.03.2017). A Two-Tailed Phosphopeptide Crystallizes to Form a Lamellar Structure. Angewandte Chemie-International Edition, 56 (12), (pp. 3252-3255) (4 p.).
Baldus, Marc (01.03.2017). High-resolution NMR in the native state. IUCrJ, 4 (2), (pp. 102-103) (2 p.).
Medeiros-silva, João, Jekhmane, Miranda, Baldus, Marc & Weingarth, Markus (01.10.2017). Hydrogen bond strength in membrane proteins probed by time-resolved 1 H-detected solid-state NMR and MD simulations. Solid State Nuclear Magnetic Resonance, 87, (pp. 80-85) (6 p.).
Pylaeva, Svetlana, Ivanov, Konstantin L., Baldus, Marc, Sebastiani, Daniel & Elgabarty, Hossam (18.05.2017). Molecular Mechanism of Overhauser Dynamic Nuclear Polarization in Insulating Solids. Journal of Physical Chemistry Letters, 8 (10), (pp. 2137-2142) (6 p.).
van der Cruijsen, Elwin A W, Prokofyev, Alexander V., Pongs, Olaf & Baldus, Marc (10.01.2017). Probing Conformational Changes during the Gating Cycle of a Potassium Channel in Lipid Bilayers. Biophysical Journal, 112 (1), (pp. 99-108) (10 p.).
Yang, Yufei, Xiang, Shengqi, Liu, Xiaodan, Pei, Xiaojing, Wu, Pengzhi, Gong, Qingguo, Li, Na, Baldus, Marc & Wang, Shenlin (26.10.2017). Proton-detected solid-state NMR detects the inter-nucleotide correlations and architecture of dimeric RNA in microcrystals. Chemical Communications, 53 (96), (pp. 12886-12889) (4 p.).
de Agrela Pinto, Cecilia, Mance, Deni, Julien, Manon, Daniels, Mark, Weingarth, Markus & Baldus, Marc (2017). Studying assembly of the BAM complex in native membranes by cellular solid-state NMR spectroscopy. Journal of Structural Biology
Visscher, Koen M., Medeiros-silva, João, Mance, Deni, Garcia Lopes Maia Rodrigues, Joao, Daniëls, Mark, Bonvin, Alexandre M. J. J., Baldus, Marc & Weingarth, Markus (16.10.2017). Supramolecular Organization and Functional Implications of K+ Channel Clusters in Membranes. Angewandte Chemie-International Edition, 56 (43), (pp. 13222-13227) (6 p.).
  2016 - Scholarly publications
Medeiros-Silva, João, Mance, Deni, Daniëls, Mark, Jekhmane, Miranda, Houben, Klaartje, Baldus, Marc & Weingarth, Markus (17.10.2016). 1H-Detected Solid-State NMR Studies of Water-Inaccessible Proteins In Vitro and In Situ. Angewandte Chemie-International Edition, 55 (43), (pp. 13606-13610) (5 p.).
Miles, A.J., Wallace, B.A., Arinaminpathy, Y., Khurana, E., Engelman, D. M., Gerstein, Mark B, Berman, Helen M., Westbrook, John D., Feng, Z., Gilliland, G., Bhat, T. N., Weissig, H., Shindyalov, I. N., Bourne, P. E., Kelly, M. J. S., Jess, T. J., Price, N.C., Miles, A.J., Wallace, B.A., Wallace, B.A., Tinoco, I., Woody, R. W., Bradley, D. F., Chin, D.-H., Woody, R. W., Rohl, C. A., Baldwin, R. L., Lees, J. G., Miles, A.J., Wien, F., Wallace, B.A., Janes, R. W., Wallace, B.A., Mao, D., Mao, D., Wallace, B.A., Dorr, J. M., Koorengevel, M. C., Schafer, Christopher M., Prokofyev, A. V., Scheidelaar, S., Cruijsen, E. A. van der, Dafforn, Timothy R, Baldus, M., Killian, J. A., Buerck, J., Wadhwani, P., Fanghaenel, S., Ulrich, A. S., Whitmore, L., Wallace, B.A., Cascio, M., Wallace, B.A., Chen, Y., Wallace, B.A., Wallace, B.A., Lees, James, Orry, A. J. W., Lobley, A., Janes, R. W., Cascio, M., Wallace, B.A., Abdul-Gader, A., Miles, A.J., Wallace, B.A., Whitmore, L., Wallace, B.A., Seddon, A. M., Curnow, P., Booth, P. J., Mao, D., Wachter, E., Wallace, B.A., Ladokhin, A. S., Fernández-Vidal, M., White, S. H., Wallace, B.A., Janes, R. W., Toumadje, A., Alcorn, S. W., Jr., W. C. Johnson, Wallace, B.A., Teeters, C. L., Teeters, C. L., Eccles, Jennifer, Wallace, B.A., Stanley, A. M., Fleming, K. G., Wien, F., Wallace, B.A., Miles, A.J., Wien, F., Lees, J. G., Wallace, B.A., Lees, J. G., Smith, Rachel B, Wien, F., Miles, A.J., Wallace, B.A., Sreerama, N., Woody, R. W., Harris, N. J., Findlay, H. E., Simms, J., Liu, X., Booth, P. J., Siligardi, G., Hussain, R., Patching, S. G., Phillips-Jones, M. K., Greenfield, N. J., WU, Y., Huang, H. W., Olah, G. A., Perrone, B., Miles, A.J., Salnikov, E. S., Wallace, B.A., Bechinger, B., Ulmschneider, Martin B., Ulmschneider, Jakob P., Schiller, N., Wallace, B.A., Von Heijne, Gunnar, Wallace, B.A., Buerck, J., Powl, A. M., O'Reilly, A. O., Miles, A.J., Wallace, B.A., Powl, A. M., Miles, A.J., Wallace, B.A., Hagelueken, G., Clarke, B. R., Tuukkanen, A., Danciu, I., Svergun, Dmitri I, Hussain, R., Liu, H., Whitfield, C., Naismith, J. H., Whitmore, L., Woollett, B., Miles, A.J., Klose, D. P., Janes, R. W., Wallace, B.A., McCusker, E. C., Bagnéris, C., Naylor, C. E., Cole, A. R., D'Avanzo, N., Nichols, C. G., Wallace, B.A., Miles, A.J., Wallace, B.A. & Esmann, M. (2016). Circular dichroism spectroscopy of membrane proteins. Chemical Society Reviews, 14, (pp. 1130-1135) (6 p.).
Kaplan, M., Narasimhan, Siddarth, de Heus, Cilia, Mance, Deni, van Doorn, Sander, Houben, Klaartje, Popov-Celeketic, Dusan, Damman, Reinier, Katrukha, Eugene A, Jain, Purvi, Geerts, Willie J C, Heck, Albert J R, Folkers, Gert E, Kapitein, Lukas C, Lemeer, Simone, van Bergen En Henegouwen, Paul M P & Baldus, Marc (17.11.2016). EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR. Cell, 167 (5), (pp. 1241-1251.e11) (11 p.). Copyright © 2016 Elsevier Inc. All rights reserved..
Fricke, Pascal, Mance, Deni, Chevelkov, Veniamin, Giller, Karin, Becker, Stefan, Baldus, Marc & Lange, Adam (01.08.2016). High resolution observed in 800 MHz DNP spectra of extremely rigid type III secretion needles. Journal of Biomolecular NMR, 65 (3), (pp. 121-126) (6 p.).
Chowdhury, Abhishek Dutta, Houben, Klaartje, Whiting, Gareth T, Mokhtar, Mohamed, Asiri, Abdullah M, Al-Thabaiti, Shaeel A, Basahel, Suliman N, Baldus, Marc & Weckhuysen, Bert M (19.12.2016). Initial Carbon-Carbon Bond Formation during the Early Stages of the Methanol-to-Olefin Process Proven by Zeolite-Trapped Acetate and Methyl Acetate. Angewandte Chemie-International Edition, 55 (51), (pp. 15840-15845) (6 p.). © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA..
Kaplan, M., de Agrela Pinto, Cecilia, Houben, Klaartje & Baldus, Marc (2016). Nuclear magnetic resonance (NMR) applied to membrane-protein complexes. Quarterly Reviews of Biophysics, 49.
Chung, Sangho, Angelici, Carlo, Hinterding, Stijn O. M., Weingarth, Markus, Baldus, Marc, Houben, Klaartje, Weckhuysen, Bert M. & Bruijnincx, Pieter C. A. (2016). Role of Magnesium Silicates in Wet-Kneaded Silica-Magnesia Catalysts for the Lebedev Ethanol-to-Butadiene Process. ACS Catalysis, 6 (6), (pp. 4034-4045) (12 p.).
Van Der Stam, Ward, Gradmann, Sabine, Altantzis, Thomas, Ke, Xiaoxing, Baldus, Marc, Bals, Sara & De Mello Donega, Celso (27.09.2016). Shape control of colloidal Cu2-xS polyhedral nanocrystals by tuning the nucleation rates. Chemistry of Materials, 28 (18), (pp. 6705-6715) (11 p.).
Yarulina, Irina, Bailleul, Simon, Pustovarenko, Alexey, Martinez, Javier Ruiz, Wispelaere, Kristof De, Hajek, Julianna, Weckhuysen, Bert M., Houben, Klaartje, Baldus, Marc, Van Speybroeck, Veronique, Kapteijn, Freek & Gascon, Jorge (06.10.2016). Suppression of the Aromatic Cycle in Methanol-to-Olefins Reaction over ZSM-5 by Post-Synthetic Modification Using Calcium. ChemCatChem, 8 (19), (pp. 3057-3063) (7 p.).
  2015 - Scholarly publications
Baldus, Marc (07.04.2015). A solid view of membrane proteins in situ. Biophysical Journal, 108 (7), (pp. 1585-1586) (2 p.).
Mance, Deni, Sinnige, Tessa, Kaplan, M., Narasimhan, Siddarth, Daniëls, Mark, Houben, Klaartje, Baldus, Marc & Weingarth, Markus (2015). An Efficient Labelling Approach to Harness Backbone and Side-Chain Protons in 1H-Detected Solid-State NMR Spectroscopy. Angewandte Chemie-International Edition, 54 (52), (pp. 15799-15803) (5 p.).
Langlois, Chantal, Ramboarina, Stéphanie, Cukkemane, Abhishek, Auzat, Isabelle, Chagot, Benjamin, Gilquin, Bernard, Ignatiou, Athanasios, Petitpas, Isabelle, Kasotakis, Emmanouil, Paternostre, Maïté, White, Helen E., Orlova, Elena V., Baldus, Marc, Tavares, Paulo & Zinn-Justin, Sophie (06.02.2015). Bacteriophage SPP1 tail tube protein self-assembles into β-structure-rich tubes. Journal of Biological Chemistry, 290 (6), (pp. 3836-3849) (14 p.).
Van Der Cruijsen, Elwin A W, Koers, Eline J., Sauvée, Claire, Hulse, Raymond E., Weingarth, Markus, Ouari, Olivier, Perozo, Eduardo, Tordo, Paul & Baldus, Marc (01.09.2015). Biomolecular DNP-Supported NMR Spectroscopy using Site-Directed Spin Labeling. Chemistry-A European Journal, 21 (37), (pp. 12971-12977) (7 p.).
Sinnige, Tessa, Weingarth, Markus, Daniels, Mark, Boelens, Rolf, Bonvin, Alexandre M. J. J., Houben, Klaartje & Baldus, Marc (07.07.2015). Conformational Plasticity of the POTRA 5 Domain in the Outer Membrane Protein Assembly Factor BamA. Structure with Folding & design, 23 (7), (pp. 1317-1324) (8 p.).
Baker, Lindsay A., Daniëls, Mark, Van Der Cruijsen, Elwin A W, Folkers, Gert E. & Baldus, Marc (04.06.2015). Efficient cellular solid-state NMR of membrane proteins by targeted protein labeling. Journal of Biomolecular NMR, 62 (2), (pp. 199-208) (10 p.).
Mathies, Guinevere, Caporini, Marc A., Michaelis, Vladimir K., Liu, Yangping, Hu, Kan Nian, Mance, Deni, Zweier, Jay L., Rosay, Melanie, Baldus, Marc & Griffin, Robert G. (01.09.2015). Efficient Dynamic Nuclear Polarization at 800 MHz/527 GHz with Trityl-Nitroxide Biradicals. Angewandte Chemie-International Edition, 54 (40), (pp. 11770-11774) (5 p.).
Sinnige, Tessa, Houben, Klaartje, Pritisanac, Iva, Renault, Marie, Boelens, Rolf & Baldus, Marc (2015). Insight into the conformational stability of membrane-embedded BamA using a combined solution and solid-state NMR approach. Journal of Biomolecular NMR, 61 (3-4), (pp. 321-32) (12 p.).
Jantschke, Anne, Koers, Eline, Mance, Deni, Weingarth, Markus, Brunner, Eike & Baldus, Marc (2015). Insight into the Supramolecular Architecture of Intact Diatom Biosilica from DNP-Supported Solid-State NMR Spectroscopy. Angewandte Chemie-International Edition, 54 (50), (pp. 15069–15073) (5 p.). © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim..
Baker, Lindsay A., Folkers, Gert E., Sinnige, Tessa, Houben, Klaartje, Kaplan, M., van der Cruijsen, Elwin A W & Baldus, Marc (01.01.2015). Magic-Angle-Spinning Solid-State NMR of Membrane Proteins. Methods in Enzymology, 557, (pp. 307-328) (22 p.).
Gebretsadik, Fiseha B., Mance, Deni, Baldus, Marc, Salagre, Pilar & Cesteros, Yolanda (01.09.2015). Microwave synthesis of delaminated acid saponites using quaternary ammonium salt or polymer as template. Study of pH influence. Applied Clay Science, 114, (pp. 20-30) (11 p.).
Kaplan, M., Cukkemane, Abhishek, Van Zundert, Gydo C P, Narasimhan, Siddarth, Daniëls, Mark, Mance, Deni, Waksman, Gabriel, Bonvin, Alexandre M J J, Fronzes, Rémi, Folkers, Gert E. & Baldus, Marc (30.06.2015). Probing a cell-embedded megadalton protein complex by DNP-supported solid-state NMR. Nature Methods, 12 (7), (pp. 649-652) (4 p.).
Van Zandvoort, Ilona, Koers, Eline J., Weingarth, Markus, Bruijnincx, Pieter C A, Baldus, Marc & Weckhuysen, Bert M. (01.08.2015). Structural characterization of 13C-enriched humins and alkali-treated 13C humins by 2D solid-state NMR. Green Chemistry, 17 (8), (pp. 4383-4392) (10 p.).
Mance, Deni, Gast, Peter, Huber, Martina, Baldus, Marc & Ivanov, Konstantin L (21.06.2015). The magnetic field dependence of cross-effect dynamic nuclear polarization under magic angle spinning. Journal of Chemical Physics, 142 (23), (pp. 234201).
Radmalekshahi, Mazda, Visscher, Koen M., Garcia Lopes Maia Rodrigues, João, De Vries, Renko, Hennink, Wim E., Baldus, Marc, Bonvin, Alexandre M J J, Mastrobattista, Enrico & Weingarth, Markus (24.06.2015). The Supramolecular Organization of a Peptide-Based Nanocarrier at High Molecular Detail. Journal of the American Chemical Society, 137 (24), (pp. 7775-7784) (10 p.).
  2014 - Scholarly publications
Baker, Lindsay A. & Baldus, Marc (2014). Characterization of membrane protein function by solid-state NMR spectroscopy. Current Opinion in Structural Biology, 27 (1), (pp. 48-55) (8 p.).
Dörr, Jonas M, Koorengevel, Martijn C, Schäfer, Marre, Prokofyev, Alexander V, Scheidelaar, Stefan, van der Cruijsen, Elwin A W, Dafforn, Timothy R, Baldus, Marc & Killian, J Antoinette (30.12.2014). Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+ channel - The power of native nanodiscs. Proceedings of the National Academy of Sciences of the United States of America, 111 (52), (pp. 18607–18612) (6 p.).
Moiset, Gemma, López, Cesar A., Bartelds, Rianne, Syga, Lukasz, Rijpkema, Egon, Cukkemane, Abhishek, Baldus, Marc, Poolman, Bert & Marrink, Siewert J. (19.11.2014). Disaccharides impact the lateral organization of lipid membranes. Journal of the American Chemical Society, 136 (46), (pp. 16167-16175) (9 p.).
Deber, Maria Pilar Lopez, Hickman, David T., Nand, Deepak, Baldus, Marc, Pfeifer, Andrea & Muhs, Andreas (10.09.2014). Engineering Amyloid-Like Assemblies from Unstructured Peptides via Site-Specific Lipid Conjugation. PLoS One, 9 (9) (10 p.).
Weingarth, M.H. & Baldus, M. (2014). Introduction to Biological Solid-State NMR. In Frances Separovic & Akira Naito (Eds.), Advances in biological solid-state nmr - proteinsand membrane-active peptides (384 p.). London: Royal Society of Chemistry.
Koers, Eline J., van der Cruijsen, Elwin A. W., Rosay, Melanie, Weingarth, Markus, Prokofyev, Alexander, Sauvee, Claire, Ouari, Olivier, van der Zwan, Johan, Pongs, Olaf, Tordo, Paul, Maas, Werner E. & Baldus, Marc (2014). NMR-based structural biology enhanced by dynamic nuclear polarization at high magnetic field. Journal of Biomolecular NMR, 60 (2-3), (pp. 157-168) (12 p.).
Can, T. V., Caporini, M. A., Mentink-Vigier, F., Corzilius, B., Walish, J. J., Rosay, M., Maas, W. E., Baldus, M., Vega, S., Swager, T. M. & Griffin, R. G. (14.08.2014). Overhauser effects in insulating solids. Journal of Chemical Physics, 141 (6).
Sattler, Jesper J. H. B., Gonzalez-Jimenez, Ines D., Luo, Lin, Stears, Brien A., Malek, Andrzej, Barton, David G., Kilos, Beata A., Kaminsky, Mark P., Verhoeven, Tiny W. G. M., Koers, Eline J., Baldus, Marc & Weckhuysen, Bert M. (25.08.2014). Platinum-promoted Ga/Al₂O₃ as highly active, selective, and stable catalyst for the dehydrogenation of propane. Angewandte Chemie-International Edition, 53 (35), (pp. 9251-9256) (6 p.).
Sinnige, Tessa, Daniëls, Mark, Baldus, Marc & Weingarth, Markus (26.03.2014). Proton clouds to measure long-range contacts between nonexchangeable side chain protons in solid-state NMR. Journal of the American Chemical Society, 136 (12), (pp. 4452-4455) (4 p.).
Weingarth, Markus, Van Der Cruijsen, Elwin A W, Ostmeyer, Jared, Lievestro, Sylke, Roux, Benoiît & Baldus, Marc (05.02.2014). Quantitative analysis of the water occupancy around the selectivity filter of a K+ channel in different gating modes. Journal of the American Chemical Society, 136 (5), (pp. 2000-2007) (8 p.).
Sinnige, Tessa, Weingarth, Markus, Renault, Marie, Baker, Lindsay, Tommassen, J & Baldus, Marc (01.05.2014). Solid-State NMR studies of full-length BamA in lipid bilayers suggest limited overall POTRA mobility. Journal of Molecular Biology, 426 (9), (pp. 2009-2021) (13 p.).
  2013 - Scholarly publications
Cukkemane, A.A. & Baldus, M. (2013). Characterization of a Cyclic Nucleotide-Activated K+ Channel and its Lipid Environment by Using Solid-State NMR Spectroscopy. ChemBioChem, 14 (14), (pp. 1789-1798) (10 p.).
Hausoul, P.J.C., Eggenhuisen, T.M., Nand, D., Baldus, M., Weckhuysen, B.M., Klein Gebbink, R.J.M. & Bruijnincx, P.C.A. (2013). Development of a 4,4’-biphenyl/phosphine-based COF for the heterogeneous Pd-catalysed telomerisation of 1,3-butadiene. Catalysis Science and Technology, 3 (10), (pp. 2571-2579) (9 p.).
Koers, E.J., López-Deber, M.P., Weingarth, M.H., Nand, D., Hickman, D.T., Mlaki Ndao, D., Reis, P., Granet, A., Pfeifer, A., Muhs, A. & Baldus, M. (2013). Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines. Angewandte Chemie-International Edition, 52 (41), (pp. 10905-10908) (4 p.).
Renault, M.A.M., García, J., Cordeiro, T.N., Baldus, M. & Pons, M. (2013). Protein oligomers studied by solid-state NMR – the case of the full-length nucleoid-associated protein histone-like nucleoid structuring protein. The FEBS journal, 280 (12), (pp. 2916-2928) (13 p.).
Weingarth, M.H. & Baldus, M. (2013). Solid-state NMR based approaches for supramolecular structure elucidation. Accounts of Chemical Research, 46 (9), (pp. 2037-2046) (10 p.).
Weingarth, M.H., Prokofyev, A., van der Cruijsen, E.A.W., Nand, D., Bonvin, A.M.J.J., Pongs, O. & Baldus, M. (2013). Structural Determinants of Specific Lipid Binding to Potassium Channels. Journal of the American Chemical Society, 135 (10), (pp. 3983-3988) (5 p.).
Labokha, A.A., Gradmann, S.H.E., Frey, S., Hülsmann, B.B., Urlaub, H., Baldus, M. & Görlich, D. (2013). Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes. EMBO Journal, 32 (2), (pp. 204-218) (15 p.).
Hornig, S., Ohmert, I., Trauner, D., Ader, C., Baldus, M. & Pongs, O. (2013). Tetraphenylporphyrin derivative specifically blocks members of the voltage-gated potassium channel subfamily Kv1. Channels, 7 (6), (pp. 473-482) (10 p.).
van der Cruijsen, E.A.W., Nand, D., Weingarth, M.H., Prokofyev, A., Hornig, S., Cukkemane, A.A., Bonvin, A.M.J.J., Becker, S., Hulse, R.E., Perozo, E., Pongs, O. & Baldus, M. (2013). The importance of the lipid-pore loop interface for potassium channel structure and function. Proceedings of the National Academy of Sciences of the United States of America, 110, (pp. 13008-13013) (6 p.).
Shi, Y., van Steenbergen, M.J., Teunissen, E.A., Novo, L., Gradmann, S., Baldus, M., van Nostrum, C.F. & Hennink, W.E. (2013). Π−Π Stacking increases the stability and loading capacity of thermosensitive polymeric micelles for chemotherapeutic drugs. Biomacromolecules, 14 (6), (pp. 1826-1837) (12 p.).
  2012 - Scholarly publications
Renault, M.A.M., Tommassen-van Boxtel, H.A.M., Bos, M.P., Post, J.A., Tommassen, J.P.M. & Baldus, M. (2012). Cellular solid-state Nuclear Magnetic Resonance spectroscopy. Proceedings of the National Academy of Sciences of the United States of America, 109 (13), (pp. 4863-4868) (6 p.).
Nand, D., Cukkemane, A.A., Becker, S. & Baldus, M. (2012). Fractional Deuteration applied to biomolecular solid-state NMR spectroscopy. Journal of Biomolecular NMR, 52 (2), (pp. 91-101) (11 p.).
Markley, John L, Akutsu, Hideo, Asakura, Tetsuo, Baldus, Marc, Boelens, Rolf, Bonvin, Alexandre, Kaptein, R, Bax, A., Bezsonova, Irina, Gryk, Michael R, Hoch, Jeffrey C, Korzhnev, Dmitry M, Maciejewski, Mark W, Case, Dave, Chazin, Walter J, Cross, Timothy A, Dames, Sonja, Kessler, Horst, Lange, Oliver, Madl, Tobias, Reif, Bernd, Sattler, Michael, Eliezer, David, Fersht, Alan, Forman-Kay, Julie, Kay, Lewis E, Fraser, James, Gross, John, Kortemme, Tanja, Sali, Andrej, Fujiwara, Toshimichi, Gardner, Kevin, Luo, Xuelian, Rizo-Rey, Jose, Rosen, Michael, Gil, Roberto R, Ho, Chien, Rule, Gordon, Gronenborn, Angela M, Ishima, Rieko, Klein-Seetharaman, Judith, Tang, Pei, van der Wel, Patrick, Xu, Yan, Grzesiek, Stephan, Hiller, Sebastian, Seelig, Joachim, Laue, Ernest D, Mott, Helen, Nietlispach, Daniel, Barsukov, Igor, Lian, Lu-Yun, Middleton, David, Blumenschein, Tharin, Moore, Geoffrey, Campbell, Iain, Schnell, Jason, Vakonakis, Ioannis John, Watts, Anthony, Conte, Maria R, Mason, James, Pfuhl, Mark, Sanderson, Mark R, Craven, Jeremy, Williamson, Michael, Dominguez, Cyril, Roberts, Gordon, Günther, Ulrich, Overduin, Michael, Werner, Joern, Williamson, Philip, Blindauer, Claudia, Crump, Matthew, Driscoll, Paul, Frenkiel, Tom, Golovanov, Alexander, Matthews, Steve, Parkinson, John, Uhrin, Dusan, Williams, Mark, Neuhaus, David, Oschkinat, Hartmut, Ramos, Andres, Shaw, David E, Steinbeck, Christoph, Vendruscolo, Michele, Vuister, Geerten W, Walters, Kylie J, Weinstein, Harel, Wüthrich, Kurt & Yokoyama, Shigeyuki (01.09.2012). In support of the BMRB. Nature Structural and Molecular Biology, 19 (9), (pp. 854-860) (7 p.).
Gradmann, S.H.E., Ader, C., Heinrich, I., Nand, D., Dittmann, M., Cukkemane, A.A., van Dijk, M., Bonvin, A.M.J.J., Engelhard, M. & Baldus, M. (2012). Rapid prediction of multi-dimensional NMR data sets. Journal of Biomolecular NMR, 54 (4), (pp. 377-387) (11 p.).
Cukkemane, A.A., Nand, D., Gradmann, S.H.E., Weingarth, M.H., Kaupp, U.B. & Baldus, M. (2012). Solid-state NMR [13C,15N] resonance assignments of the nucleotide-Binding Domain of a bacterial Cyclic Nucleotide-Gated Channel. Journal of Biomolecular NMR, 6 (2), (pp. 225-229) (5 p.).
Renault, M.A.M., Pawsey, S., Bos, M.P., Koers, E.J., Nand, D., Tommassen-van Boxtel, H.A.M., Rosay, M., Tommassen, J.P.M., Maas, W.E. & Baldus, M. (2012). Solid-State NMR Spectroscopy on Cellular Preparations Enhanced by Dynamic Nuclear Polarization. Angewandte Chemie-International Edition, 51 (12), (pp. 2998-3001) (4 p.).
Weingarth, M.H., Ader, C., Melquiond, A.S.J., Nand, D., Pongs, O., Becker, S., Bonvin, A.M.J.J. & Baldus, M. (2012). Supramolecular structure of membrane-associated polypeptides by combining solid-state NMR and Molecular Dynamics simulations. Biophysical Journal, 103 (1), (pp. 29-37) (9 p.).
  2011 - Scholarly publications
Etzkorn, M., Böckmann, A. & Baldus, M. (2011). Kinetic analysis of protein aggregation monitored by real-time 2D solid-state NMR spectroscopy. Journal of Biomolecular NMR, 49, (pp. 121-129) (9 p.).
de Graaf, A.J., Boere, K.W.M., Kemmink, J., Fokkink, R.G., van Nostrum, C.F., Rijkers, D.T.S., van de Gucht, J., Wienk, H.L.J., Baldus, M., Mastrobattista, E., Vermonden, T. & Hennink, W.E. (2011). Looped structure of flowerlike Micelles revealed by 1H NMR relaxometry and light scattering. Langmuir, 27 (16), (pp. 9843-9848) (6 p.).
Adler, C., Baldus, M. & Becker, S. (2011). Membrane Associated Systems: structural studies by MASNMR. Encyclopedia of Magnetic Resonance
Hickman, D.T., Nand, D., Baldus, M. & Muhs, A. (2011). Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases. Journal of Biological Chemistry, 286 (16), (pp. 13966-13976) (11 p.).
Renault, M.A.M., Bos, M.P., Tommassen, J.P.M. & Baldus, M. (2011). Solid-state NMR on a large multidomain integral membrane protein: the outer membrane protein assembly factor BamA. Journal of the American Chemical Society, 133 (12), (pp. 4175-4177) (3 p.).
Schneider, R., Schumacher, M.C., Mueller, H., Nand, D., Klaukien, V., Heise, H., Riedel, D., Wolf, G., Behrmann, E., Raunser, S., Seidel, R., Engelhard, M. & Baldus, M. (2011). Structural characterization of polyglutamine fibrils by solid-state NMR spectroscopy. Journal of Molecular Biology, 412 (1), (pp. 121-136) (16 p.).
  2010 - Scholarly publications
Ader, C., Frey, S., Maas, W., Schmidt, H. B., Görlich, D. & Baldus, M. (2010). Amyloid-like interactions within nucleoporin FG hydrogels. Proceedings of the National Academy of Sciences of the United States of America, 107 (14), (pp. 6281-6285) (5 p.). Cited By (since 1996): 4.
Etzkorn, M., Seidel, K., Li, L., Martell, S., Geyer, M., Engelhard, M. & Baldus, M. (2010). Complex Formation and Light Activation in Membrane-Embedded Sensory Rhodopsin II as Seen by Solid-State NMR Spectroscopy. Structure with Folding & design, 18 (3), (pp. 293-300) (8 p.). Cited By (since 1996): 2 20th International conference on Plant Growth Substances (IPGSA)..
Kumar, A., Heise, H., Blommers, M. J. J., Krastel, P., Schmitt, E., Petersen, F., Jeganathan, S., Mandelkow, E. -M, Carlomagno, T., Griesinger, C. & Baldus, M. (2010). Interaction of epothilone B (patupilone) with microtubules as detected by two-dimensional solid-state NMR spectroscopy. Angewandte Chemie-International Edition, 49 (41), (pp. 7504-7507) (4 p.).
Schneider, R., Seidel, K., Etzkorn, M., de Lange, A., Becker, S. & Baldus, M. (2010). Probing molecular motion by double-quantum (13C,13C) solid-state NMR spectroscopy: Application to ubiquitin. Journal of the American Chemical Society, 132 (1), (pp. 223-233) (11 p.). Cited By (since 1996): 3.
Ader, C., Pongs, O., Becker, S. & Baldus, M. (2010). Protein dynamics detected in a membrane-embedded potassium channel using two-dimensional solid-state NMR spectroscopy. Biochimica et Biophysica Acta - Biomembranes, 1798 (2), (pp. 286-290) (5 p.). Cited By (since 1996): 3.
Poyraz, O., Schmidt, H., Seidel, K., Delissen, F., Ader, C., Tenenboim, H., Goosmann, C., Laube, B., Thünemann, A. F., Zychlinsky, A., Baldus, M., de Lange, A., Griesinger, C. & Kolbe, M. (2010). Protein refolding is required for assembly of the type three secretion needle. Nature Structural and Molecular Biology, 17 (7), (pp. 788-792) (5 p.). Cited By (since 1996): 1.
Bardiaux, B., Favier, A., Etzkorn, M., Baldus, M., Böckmann, A., Nilges, M. & Malliavin, T.E. (2010). Simultaneous use of solution, solid-state NMR and X-ray crystallography to study the conformational landscape of the Crh protein during oligomerization and crystallization. Advances and Applications in Bioinformatics and Chemistry, 3, (pp. 25-38) (14 p.).
Renault, M.A.M., Cukkemane, A.A. & Baldus, M. (2010). Solid-state NMR spectroscopy on complex biomolecules. Angewandte Chemie-International Edition, 49 (45), (pp. 8346-8357) (12 p.).
  2009 - Scholarly publications
Seidel, K., Etzkorn, M., Schneider, R., Ader, C. & Baldus, M. (2009). Comparative analysis of NMR chemical shift predictions for proteins in the solid phase. Solid State Nuclear Magnetic Resonance, 35 (4), (pp. 235-242) (8 p.).
Ader, C., Schneider, R., Hornig, S., Velisetty, P., Vardanyan, V., Giller, K., Ohmert, I., Becker, S., Pongs, O. & Baldus, M. (2009). Coupling of activation and inactivation gate in a K+-channel: potassium and ligand sensitivity. EMBO Journal, 28, (pp. 2825-2834) (10 p.).
Kneuper, H., Scheu, P., Etzkorn, M., Sevvana, M., Dunnwald, P., Baldus, M., Griesinger, C. & Unden, G. (2009). Onbekend. In S. Spiro & R. Dixon (Eds.), Sensory mechanisms in bacteria Norwich: Horizon Press, Book op web-site niet aangekondigd bij Horizon Press!!.
Karpinar, D.P., Giller, K., Becker, S. & Baldus, M. (2009). Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models. EMBO Journal, 28, (pp. 3256-3268) (13 p.). Samen met nog 20 andere auteurs.
Ader, C., Schneider, R., Seidel, K., Etzkorn, M., Becker, S. & Baldus, M. (2009). Structural rearrangements of membrane proteins probed by water-edited solid-state NMR spectroscopy. Journal of the American Chemical Society, 131 (1), (pp. 170-176) (7 p.).
  2008 - Scholarly publications
Etzkorn, M., Kneuper, H., Dünnwald, P., Vijayan, V., Krämer, J., Griesinger, C., Becker, S., Unden, G. & Baldus, M. (2008). Plasticity of the PAS domain and a potential role for signal transduction in the histidine kinase DcuS. Nature Structural and Molecular Biology, 15 (10), (pp. 1031-1039) (9 p.).
  2004 - Scholarly publications
Andronesi, O.C., Pfeifer, J.R., Al-Momani, L., Özdirekcan, S., Rijkers, D.T.S., Angerstein, B., Luca, S., Koert, U., Killian, J.A. & Baldus, M. (2004). Probing membrane protein orientation and structure using fast magic-angle-spinning solid-state NMR. Journal of Biomolecular NMR, 30, (pp. 253-265) (13 p.).
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Gegenereerd op 2018-09-22 08:10:03

Nuclear Magnetic Resonance (NMR) can provide atomic-level insight into the structure and dynamics of heterogeneous systems. Our group develops NMR-based approaches targeting such molecular arrangements by combining recent advancements in solid-state NMR to enhance spectroscopic sensitivity and resolution with dedicated biochemical and biophysical techniques. 

Our methods development ranges from NMR pulse schemes (see, e.g., our recent review) and hyperpolarization methods  to dedicated labelling and software analysis tools.

We have used such methods to study protein aggregation and fibril formation in the context of Alzheimer's and Parkison's disease. Moreover, we could elucidate the binding mode of ligands such as peptides, proteins and small molecules to complex molecular systems such as membrane embedded G-protein coupled receptors and ion channels or polymeric proteins related to bacterial secretion and the nuclear pore complex

Recently we used such concepts to study drug delivery systems at atomic level (see. e,g. Koers et al.). Moreover, we have shown how NMR can be used to obtain direct insight into how proteins execute their function in a cellular membrane environment (see. e,g.,  Vd Cruijsen et al.).

At presented we design novel NMR approaches to study structure and function of protein complexes that are associated in prokaryotic and eukaryotic cells (see, e.g., Renault et al.) and that are implicated in a variety of diseases including Alzheimer's disease, antibiotic resistance and cancer. 


Gegenereerd op 2018-09-22 08:10:03


Molecular Machines 

Concepts in Molecular Life Sciences 

Summer school Exploring Nature's Molecular Machines 

Structure analysis 

Biophysical Chemistry 

NMR & Molecular Modelling 

Gegenereerd op 2018-09-22 08:10:03
Additional functions and activities

2013-2019 ERC CdG review panel member .

2017 & 2018 NWO Start-up review panel member

Member of the international organizing committee of the 2019 EBSA meeting, Madrid, Spain.

Member of the international organizing committee of the 2018 MR Hyperpolarization meeting, Southampton, UK

Member of the Scientific Advisory Board in Chemistry, Lorentz Center, Leiden

Member of scientific advisory Committee of the National French High field Facility (TGIR RMN THC)

Coordinator, uNMR-NL consortium (national NMR consortium)

Gegenereerd op 2018-09-22 08:10:03
Full name
prof. dr. M. Baldus Contact details
Nicolaas Bloembergengebouw

Padualaan 12
Room 1.14
The Netherlands

Phone number (direct) +31 30 253 3801
Phone number (department) +31 30 253 2652
Gegenereerd op 2018-09-22 08:10:03
Last updated 12.07.2018