dr. L.C. (Louis) Penning
Associate Professor

Gegenereerd op 2017-11-20 07:08:43


All publications
  Articles - 2017
Dirksen, Karen, Spee, Bart, Penning, Louis C, van den Ingh, Ted S G A M, Burgener, Iwan A, Watson, Adrian L, Groot Koerkamp, Marian, Rothuizen, Jan, van Steenbeek, Frank G & Fieten, Hille (2017). Gene expression patterns in the progression of canine copper-associated chronic hepatitis. PLoS One, 12 (5), (pp. e0176826).
Kruitwagen, Hedwig S, Oosterhoff, Loes A, Vernooij, Ingrid G W H, Schrall, Ingrid M, van Wolferen, Monique E, Bannink, Farah, Roesch, Camille, van Uden, Lisa, Molenaar, Martijn R, Helms, J Bernd, Grinwis, Guy C M, Verstegen, Monique M A, van der Laan, Luc J W, Huch, Meritxell, Geijsen, Niels, Vries, Robert G, Clevers, Hans, Rothuizen, Jan, Schotanus, Baukje A, Penning, Louis C & Spee, Bart (2017). Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis. Stem Cell Reports Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved..
Dirksen, K, Burgener, I A, Rothuizen, J, van den Ingh, T S G A M, Penning, L C, Spee, B & Fieten, H (2017). Sensitivity and Specificity of Plasma ALT, ALP, and Bile Acids for Hepatitis in Labrador Retrievers. Journal of Veterinary Internal Medicine Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine..
  Articles - 2016
Malagola, Ermanno, Teunissen, Michelle, van der Laan, Luc J W, Verstegen, Monique, Schotanus, Baukje Akke, van Steenbeek, Frank G, Penning, Louis C, van Wolferen, Monique E, Tryfonidou, Marianna A & Spee, Bart (2016). Characterization and comparison of canine multipotent stromal cells derived from liver and bone marrow. Stem Cells and Development, 35 (2).
Nantasanti, Sathidpak, de Bruin, Alain, Rothuizen, Jan, Penning, Louis C & Schotanus, Baukje A (2016). Concise Review - Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals. Stem cells translational medicine, 5 (3), (pp. 325–330). ©AlphaMed Press..
Dirksen, K, Roelen, Y S, van Wolferen, M E, Kruitwagen, H S, Penning, L C, Burgener, I A, Spee, B & Fieten, H (2016). Erythrocyte copper chaperone for superoxide dismutase and superoxide dismutase as biomarkers for hepatic copper concentrations in Labrador retrievers. Veterinary Journal, 218, (pp. 1-6) (6 p.). Copyright © 2016 Elsevier Ltd. All rights reserved..
Meneses, Andre, Schneeberger, Kerstin, Kruitwagen, Hedwig, Penning, Louis, van Steenbeek, Frank, Burgener, Iwan & Spee, Bart (21.10.2016). Intestinal Organoids—Current and Future Applications. Veterinary Sciences, 3 (4), (pp. 31) (1 p.).
van Rijn, Sarah, Galac, S., Tryfonidou, M. A., Hesselink, J. W., Penning, L. C., Kooistra, H. S. & Meij, B. P. (01.07.2016). The Influence of Pituitary Size on Outcome After Transsphenoidal Hypophysectomy in a Large Cohort of Dogs with Pituitary-Dependent Hypercortisolism. Journal of Veterinary Internal Medicine, 30 (4), (pp. 989-995) (7 p.).
Dirksen, K, Verzijl, T, Grinwis, G C, Favier, R P, Penning, L C, Burgener, I A, van der Laan, L J, Fieten, H & Spee, B (2016). Use of Serum MicroRNAs as Biomarker for Hepatobiliary Diseases in Dogs. Journal of Veterinary Internal Medicine, 30 (6), (pp. 1816-1823) (8 p.). Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine..
  Articles - 2015
Favier, Robert P, Spee, Bart, Fieten, Hille, van den Ingh, Ted S G A M, Schotanus, Baukje A, Brinkhof, Bas, Rothuizen, Jan & Penning, Louis C (2015). Aberrant expression of copper associated genes after copper accumulation in COMMD1-deficient dogs. Journal of Trace Elements in Medicine and Biology, 29, (pp. 347-53) (7 p.). Copyright © 2014 Elsevier GmbH. All rights reserved..
Nantasanti, Sathidpak, Spee, Bart, Kruitwagen, Hedwig S, Chen, Chen, Geijsen, Niels, Oosterhoff, Loes A, van Wolferen, Monique E, Pelaez, Nicolas, Fieten, Hille, Wubbolts, Richard W, Grinwis, Guy C, Chan, Jefferson, Huch, Meritxell, Vries, Robert R G, Clevers, Hans, de Bruin, Alain, Rothuizen, Jan, Penning, Louis C & Schotanus, Baukje A (2015). Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports, 5 (5), (pp. 895-907) (13 p.).
van Rijn, Sarah J, Pouwer, Marianne G, Tryfonidou, Marianna A, Grinwis, Guy C M, van der Bend, Joanne E E, Beukers, Pauline E P F, Vastenhout, Nadie, Drouin, Jacques, Penning, Louis C & Meij, Björn P (15.04.2015). Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas. Veterinary Journal, 204 (3), (pp. 315-321) (7 p.). Copyright © 2015 Elsevier Ltd. All rights reserved..
van Dongen, Astrid M, Heuving, Susanne M, Tryfonidou, Marianna A, van Steenbeek, Frank G, Rothuizen, Jan & Penning, Louis C (2015). Increased bone morphogenetic protein 7 signalling in the kidneys of dogs affected with a congenital portosystemic shunt. Veterinary Journal, 204 (2), (pp. 226-228) (3 p.). Copyright © 2015 Elsevier Ltd. All rights reserved..
Stassen, Quirine E M, Riemers, Frank M, Reijmerink, Hannah, Leegwater, Peter A J & Penning, Louis C (2015). Reference genes for reverse transcription quantitative PCR in canine brain tissue. BMC Research Notes, 8 (1) (8 p.).
van Rijn, S J, Hanson, J M, Zierikzee, D, Kooistra, H S, Penning, L C, Tryfonidou, M A & Meij, B P (2015). The Prognostic Value of Perioperative Profiles of ACTH and Cortisol for Recurrence after Transsphenoidal Hypophysectomy in Dogs with Corticotroph Adenomas. Journal of Veterinary Internal Medicine, 29 (3), (pp. 869-876) (8 p.). Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine..
  Articles - 2014
Otte, Corma Ma, Rothuizen, Jan, Favier, Robert P, Penning, Louis C & Vreman, Sandra (2014). A morphological and immunohistochemical study of the effects of prednisolone or ursodeoxycholic acid on liver histology in feline lymphocytic cholangitis. Journal of Feline Medicine and Surgery, 16 (10), (pp. 796-804) (9 p.). © ISFM and AAFP 2014..
van der Laan, L J W, de Ruiter, P E, van Gils, I M, Fieten, H, Spee, B, Pan, Q, Rothuizen, J & Penning, L C (2014). Canine hepacivirus and idiopathic hepatitis in dogs from a Dutch cohort. Journal of Viral Hepatitis, 21 (12), (pp. 894-896) (3 p.). © 2014 John Wiley & Sons Ltd..
Schotanus, Baukje A, Kruitwagen, Hedwig S, van den Ingh, Ted, van Wolferen, Monique E, Rothuizen, Jan, Penning, Louis C & Spee, Bart (31.12.2014). Enhanced Wnt/ß-catenin and Notch signalling in the activated canine hepatic progenitor cell niche. BMC Veterinary Research, 10 (9 p.).
van Rijn, Sarah J, Riemers, Frank M, van den Heuvel, Douwe, Wolfswinkel, Jeannette, Hofland, Leo, Meij, Björn P & Penning, Louis C (2014). Expression stability of reference genes for quantitative RT-PCR of healthy and diseased pituitary tissue samples varies between humans, mice, and dogs. Molecular Neurobiology, 49 (2), (pp. 893-899) (7 p.).
Fieten, H., Penning, L.C., Leegwater, P.A.J. & Rothuizen, J. (2014). New canine models of copper toxicosis: diagnosis, treatment, and genetics. Annals of the New York Academy of Sciences, 1314, (pp. 42-48) (7 p.).
Bach, Frances C, Willems, Nicole, Penning, Louis C, Ito, Keita, Meij, Björn P & Tryfonidou, Marianna A (2014). Potential regenerative treatment strategies for intervertebral disc degeneration in dogs. BMC Veterinary Research, 10.
Kruitwagen, H S, Spee, B, Viebahn, C S, Venema, H B, Penning, L C, Grinwis, G C M, Favier, R P, van den Ingh, T S G A M, Rothuizen, J & Schotanus, B A (2014). The canine hepatic progenitor cell niche - molecular characterisation in health and disease. Veterinary Journal, 201 (3), (pp. 345–352) (8 p.). Copyright © 2014 Elsevier Ltd. All rights reserved..
Bach, Frances C, Rutten, Kirsten, Hendriks, Kristyanne, Riemers, Frank M, Cornelissen, Peter, de Bruin, Alain, Arkesteijn, Ger J, Wubbolts, Richard, Horton, William A, Penning, Louis C & Tryfonidou, Marianna A (2014). The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes. Journal of Cellular Physiology, 229 (12), (pp. 1999-2014) (16 p.).
Boerkamp, Kim M, van Steenbeek, Frank G, Penning, Louis C, Groot Koerkamp, Marian J A, van Leenen, Dik, Vos-Loohuis, Manon, Grinwis, Guy C M & Rutteman, Gerard R (2014). The two main forms of histiocytic sarcoma in the predisposed Flatcoated retriever dog display variation in gene expression. PLoS One, 9 (6) (8 p.).
  Articles - 2013
Favier, Robert P, Poldervaart, Joost H, van den Ingh, Ted S G A M, Penning, Louis C & Rothuizen, Jan (2013). A retrospective study of oral prednisolone treatment in canine chronic hepatitis. Veterinary Quarterly, 33 (3), (pp. 113-120) (8 p.).
van Steenbeek, F.G., van den Bossche, L., Grinwis, G.C.M., Kummeling, A., Gils, I.H., Koerkamp, M.G., van Leenen, D., Holstege, F.C., Penning, L.C., Rothuizen, J., Leegwater, P.A.J. & Spee, B. (2013). Aberrant gene expression in dogs with portosystemic shunts. PLoS One, 8 (2), (pp. e57662) (1 p.).
van Steenbeek, F.G., Spee, B., Penning, L.C., Kummeling, A., Gils, I.H., Grinwis, G.C.M., van Leenen, D., Holstege, F.C.P., Vos-Loohuis, M., Rothuizen, J. & Leegwater, P.A.J. (2013). Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs. PLoS One, 8 (3), (pp. e57973) (1 p.).
Smolders, L.A., Meij, B.P., Onis, D., Riemers, F.M., Bergknut, N., Wubbolts, R.W., Grinwis, G.C.M., Houweling, M., Groot Koerkamp, M.J.A., van Leenen, D., Holstege, F.C.P., Hazewinkel, H.A.W., Creemers, L.B., Penning, L.C. & Tryfonidou, M.A. (2013). Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Research and Therapy, 15 (1), (pp. R23) (1 p.).
Boerkamp, K.M., van der Kooij, M.A., van Steenbeek, F.G., van Wolferen, M.E., Groot Koerkamp, M.J.A., van Leenen, D., Grinwis, G.C.M., Penning, L.C., Wiemer, E.A. & Rutteman, G.R. (2013). Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog. PLoS One, 8, (pp. e71094) (1 p.).
Schotanus, B.A., Penning, L.C. & Spee, B. (2013). Potential of regenerative medicine techniques in canine hepatology. Veterinary Quarterly, 33 (4), (pp. 207-216) (10 p.).
Otte, C.M.A., Penning, L.C., Rothuizen, J. & Favier, R.P. (2013). Retrospective comparison of prednisolone and ursodeoxycholic acid for the treatment of feline lymphocytic cholangitis. Veterinary Journal, 195 (februari 2013), (pp. 205-209) (5 p.).
van Rijn, Sarah J, Tryfonidou, Marianna A, Hanson, Jeanette M, Penning, Louis C & Meij, Björn P (2013). Stem cells in the canine pituitary gland and in pituitary adenomas. Veterinary Quarterly, 33 (4), (pp. 217-224) (8 p.).
  Articles - 2012
Smolders, L.A., Meij, B.P., Riemers, F.M., Licht, R., Wubbolts, R.W., van den Heuvel, D.J., Grinwis, G.C.M., Vernooij, Hans, Hazewinkel, H.A.W., Penning, L.C. & Tryfonidou, M.A. (2012). Canonical Wnt Signaling in the Notochordal Cell is Upregulated in Early Intervertebral Disk Degeneration. Journal of Orthopaedic Research, 30 (6), (pp. 950-957) (8 p.).
Favier, Robert P, Spee, Bart, Schotanus, Baukje A, van den Ingh, Ted S G A M, Fieten, Hille, Brinkhof, Bas, Viebahn, Cornelia S, Penning, Louis C & Rothuizen, Jan (2012). COMMD1-Deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis. PLoS One, 7 (8), (pp. e42158).
Otte, C., Gutiérrez, O.P., Favier, R.P., Rothuizen, J. & Penning, L.C. (2012). Detection of bacterial DNA in bile of cats with lymphocytic cholangitis. Veterinary Microbiology, 156 (1-2), (pp. 217-221) (5 p.).
Kummeling, A., Penning, L.C., Rothuizen, J., Brinkhof, B., Weber, M.F. & van Sluijs, F.J. (2012). Hepatic gene expression and plasma albumin concentration related to outcome after attenuation of a congenital portosystemic shunt in dogs. Veterinary Journal, 191 (3), (pp. 383-388) (6 p.).
van Rijn, Sarah J, Gremeaux, Lies, Riemers, Frank M, Brinkhof, Bas, Vankelecom, Hugo, Penning, Louis C & Meij, Björn P (2012). Identification and characterisation of side population cells in the canine pituitary gland. Veterinary Journal, 192 (3), (pp. 476-482) (7 p.). Copyright © 2011 Elsevier Ltd. All rights reserved..
Bustin, S.A. & Penning, L.C. (2012). Improving the analysis of quantitative PCR data in veterinary research. Veterinary Journal, 191 (3), (pp. 279-281) (3 p.).
Corbee, R.J., Booij-Vrieling, H.E., van de Lest, C.H.A., Penning, L.C., Tryfonidou, M.A., Riemers, F.M. & Hazewinkel, H.A.W. (2012). Inflammation and wound healing in cats with chronic gingivitis/stomatitis after extraction of all premolars and molars were not affected by feeding of two diets with different omega-6/omega-3 polyunsaturated fatty acid ratios. Journal of Animal Physiology and Animal Nutrition, 96 (2012), (pp. 679-688) (10 p.).
Piek, C.J., Brinkhof, B., Rothuizen, J., Dekker, A. & Penning, L.C. (2012). Leukocyte count affects expression of reference genes in canine whole blood samples. BMC Research Notes, 4, (pp. 10.1186/1756-0500-4-36) (21 p.).
Piek, C.J., Brinkhof, B., Rothuizen, J., Dekker, A. & Penning, L.C. (2012). Leukocyte count affects expression of reference genes in canine whole blood samples. BMC Evolutionary Biology, 2011 (4), (pp. 36-36) (1 p.).
Booij-Vrieling, H.E., de Vries, T.J., Schoenmaker, T., Tryfonidou, M.A., Penning, L.C., Hazewinkel, H.A.W. & Everts, V. (2012). Osteoclast progenitors from cats with and without tooth resorption respond differently to 1,25-dihydroxyvitamin D and interleukin-6. Research in Veterinary Science, 92 (2012), (pp. 311-316) (6 p.).
van der Heijden, M., de Vries, M., van Steenbeek, F.G., Favier, R.P., Deijs, M., Brinkhof, B., Rothuizen, J., van der Hoek, L. & Penning, L.C. (2012). Sequence-independent VIDISCA-454 technique to discover new viruses in canine livers. Journal of Virological Methods, 185 (1), (pp. 152-155) (4 p.).
Bergknut, Niklas, Rutges, Joost P H J, Kranenburg, Hendrik-Jan C, Smolders, Lucas A, Hagman, Ragnvi, Smidt, Hendrik-Jan, Lagerstedt, Anne-Sofie, Penning, Louis C, Voorhout, George, Hazewinkel, Herman A W, Grinwis, Guy C M, Creemers, Laura B, Meij, Björn P & Dhert, Wouter J A (2012). The dog as an animal model for intervertebral disc degeneration?. Spine, 37 (5), (pp. 351-358) (8 p.).
  Articles - 2011
Otte, C., Penning, L.C., Rothuizen, J. & Favier, R.P. (2011). [Cholangitis in cats: symptoms, cause, diagnosis, treatment, and prognosis.]. Tijdschrift voor Diergeneeskunde, 136 (5), (pp. 332-338) (7 p.). Tijdschr Diergeneeskd. 2011 May 1;136(5):332-8. [Cholangitis in cats: symptoms, cause, diagnosis, treatment, and prognosis]. Otte CM, Penning LC, Rothuizen J, Favier RP..
Favier, R.P., Spee, B., Penning, L.C. & Rothuizen, J. (2011). Copper-induced hepatitis: the COMMD1 deficient dog as a translational animal model for human chronic hepatitis. Veterinary Quarterly, 31 (1), (pp. 49-60) (12 p.).
Piek, C.J., Brinkhof, B., Teske, E., Rothuizen, J., Dekker, A. & Penning, L.C. (2011). High intravascular tissue factor expression in dogs with idiopathic immune-mediated haemolytic anaemia. Veterinary Immunology and Immunopathology, 144 (2011), (pp. 346-354) (9 p.).
Piek, Christine J, Brinkhof, Bas, Rothuizen, Jan, Dekker, Aldo & Penning, Louis C (2011). Leukocyte count affects expression of reference genes in canine whole blood samples. BMC Research Notes, 4, (pp. 36).
Kruitwagen, H.S., Arends, B., Spee, B., Brinkhof, B., van den Ingh, T.S.G.A.M., Rutten, V.P.M.G., Penning, L.C., Roskams, T. & Rothuizen, J. (2011). Recombinant hepatocyte growth factor treatment in a canine model of congenital liver hypoplasia. Liver International, 31 (7), (pp. 940-949) (10 p.).
  Articles - 2010
IJzer, J., Schotanus, B.A., Vander Borght, S., Roskams, T.A., Kisjes, R., Penning, L.C., Rothuizen, J. & van den Ingh, T.S.G.A.M. (2010). Characterisation of the hepatic progenitor cell compartment in normal liver and in hepatitis: An immunohistochemical comparison between dog and man. Veterinary Journal, 184, (pp. 308-314) (7 p.).
Booij-Vrieling, H.E., van der Reijden, W.A., Houwers, D.J., de Wit, W.E., Bosch-Tijhof, C.J., Penning, L.C., van Winkelhoff, A.J. & Hazewinkel, H.A.W. (2010). Comparison of periodontal pathogens between cats and their owners. Veterinary Microbiology, 144, (pp. 147-152) (6 p.).
van Rijn, S J, Grinwis, G C M, Penning, L C & Meij, B P (2010). Expression of Ki-67, PCNA, and p27kip1 in canine pituitary corticotroph adenomas. Domestic Animal Endocrinology, 38 (4), (pp. 244-252) (9 p.). Copyright (c) 2009 Elsevier Inc. All rights reserved..
Vrieling, H.E., Ferbus, D., Tryfonidou, M.A., Riemers, F.M., Penning, L.C., Berdal, A., Everts, V. & Hazewinkel, H.A.W. (2010). Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats. European Journal of Oral Sciences, 118 (1), (pp. 39-46) (8 p.).
Tryfonidou, M A, Hazewinkel, H A W, Riemers, F M, Brinkhof, B, Penning, L C & Karperien, M (2010). Intraspecies disparity in growth rate is associated with differences in expression of local growth plate regulators. American Journal of Physiology - Endocrinology and Metabolism, 299 (6), (pp. 1044-1052) (9 p.).
Sprundel, R.G., van den Ingh, T.S.G.A.M., Desmet, V.J., Katoonizadeh, A., Penning, L.C., Rothuizen, J., Roskams, T. & Spee, B. (2010). Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours. Comparative Hepatology, 9, (pp. 4) (11 p.).
Bustin, S.A., Beaulieu, J.F., Huggett, J., Jaggi, R., Kibenge, F.S., Olsvik, P.A., Penning, L.C. & Toegel, S. (2010). MIQE précis: Practical implementation of minimum standard guidelines for fluorescence-based quantitative real-time PCR experiments. BMC Molecular Biology, 11, (pp. 74) (5 p.).
Kuijk, E.W., van Mil, A., Brinkhof, B., Penning, L.C., Colenbrander, B. & Roelen, B.A.J. (2010). PTEN and TRP53 independently suppress Nanog expression in spermatogonial stem cells. Stem Cells and Development, 19, (pp. 979-988) (10 p.).
  Articles - 2009
Schlotter, Y.M., Veenhof, E.Z., Brinkhof, B., Rutten, V.P.M.G., Spee, B., Willemse, A. & Penning, L.C. (2009). A GeNorm algorithm-based selection of reference genes for quantitative real-time PCR in skin biopsies of healthy dogs and dogs with atopic dermatitis. Veterinary Immunology and Immunopathology, 129 (1-2), (pp. 115-118) (4 p.).
Hoffmann, G., IJzer, J., Brinkhof, B., Schotanus, B.A., van den Ingh, T.S.G.A.M., Penning, L.C. & Rothuizen, J. (2009). Comparison of different methods to obtain and store liver biopsies for molecular and histological research. Comparative Hepatology, 8, (pp. 3) (1 p.). doi: 10.1186/1476-5926-8-3.
Schotanus, B.A., van den Ingh, T.S.G.A.M., Penning, L.C., Rothuizen, J., Roskams, T.A. & Spee, B. (2009). Cross-species immunohistochemical investigation of the activation of the liver progenitor cell niche in different types of liver disease. Liver International, 28 (9), (pp. 1241-1252) (12 p.).
Fieten, H, Spee, B, Ijzer, J, Kik, M J, Penning, L C & Kirpensteijn, J (2009). Expression of hepatocyte growth factor and the proto-oncogenic receptor c-Met in canine osteosarcoma. Veterinary Pathology, 46 (5), (pp. 869-877) (9 p.).
Arends, B., Spee, B., Schotanus, B.A., Roskams, T., van den Ingh, T.S.G.A.M., Penning, L.C. & Rothuizen, J. (2009). In vitro differentiation of liver progenitor cells derived from healthy dog livers. Stem Cells and Development, 18 (2), (pp. 351-358) (8 p.).
Vrieling, H.E., Tryfonidou, M.A., Riemers, F.M., Penning, L.C. & Hazewinkel, H.A.W. (2009). Inflammatory cytokines and the nuclear vitamin D receptor are implicated in the pathophysiology of dental resorptive lesions in cats. Veterinary Immunology and Immunopathology, 132, (pp. 160-166) (7 p.).
Poldervaart, J.H., Favier, R.P., Penning, L.C., van den Ingh, T.S.G.A.M. & Rothuizen, J. (2009). Primary hepatitis in dogs: a retrospective review (2002-2006). Journal of Veterinary Internal Medicine, 23 (1), (pp. 72-80) (9 p.).
Arends, B., Vankelecom, H., van der Borght, S., Roskams, T., Penning, L.C., Rothuizen, J. & Spee, B. (2009). The dog liver contains a "side population" of cells with hepatic progenitor-like characteristics. Stem Cells and Development, 18 (2), (pp. 343-350) (8 p.).
IJzer, J., Kisjes, R., Penning, L.C., Rothuizen, J. & van den Ingh, T.S.G.A.M. (2009). The progenitor cell compartment in the feline liver: an (immuno)histochemical investigation. Veterinary Pathology, 46 (4), (pp. 614-621) (8 p.).
  Articles - 2008
Schotanus, B.A., de Gier, J., van der Lugt, J.J., Schaefers-Okkens, A.C. & Penning, L.C. (2008). Estriolum treatment in the bitch: a risk for uterine infection?. Reproduction in Domestic Animals, 43 (2), (pp. 176-180) (5 p.).
Arends, B., Slump, E., Spee, B., Rothuizen, J. & Penning, L.C. (2008). Hepatocyte growth factor improves viability after H2O2-induced toxicity in bile duct epithelial cells. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 147 (3), (pp. 324-330) (7 p.).
Arends, B., Spee, B., Hoffmann, G., Jansen, G.E.G., Slump, E., Auriemma, E., IJzer, J., Hemrika, W., Romijn, R.A.P., Van der Heijden-Liefkens, K.H.A., Sondermeijer, P.J.A., van den Ingh, T.S.G.A.M., Penning, L.C. & Rothuizen, J. (2008). In vitro and in vivo bioactivity of recombinant canine hepatocyte growth factor. Veterinary Journal, 178, (pp. 70-77) (8 p.).
  Articles - 2007
Penning, L.C., Vrieling, H.E., Brinkhof, B., Rothuizen, J., Rutteman, G.R. & Hazewinkel, H.A.W. (2007). A validation of 10 feline reference genes for gene expression measurements in snap-frozen tissues. Veterinary Immunology and Immunopathology, 120 (15-12-2007), (pp. 212-222) (11 p.).
Spee, B., Arends, B., Wees, A.M., Bode, P., Penning, L.C. & Rothuizen, J. (2007). Functional consequences of RNA interference targeting COMMD1 in a canine hepatic cell line in relation to copper toxicosis. Animal Genetics, 38, (pp. 168-170) (3 p.).
Spee, Bart, Arends, Brigitte, van den Ingh, Ted S G A M, Roskams, Tania, Rothuizen, Jan & Penning, Louis C (2007). Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosis. Comparative Hepatology, 6, (pp. 8) (1 p.).
  Articles - 2006
Spee, B., Arends, B., van den Ingh, T.S.G.A.M., Penning, L.C. & Rothuizen, J. (2006). Copper metabolism and oxidative stress in chronic inflammatory and cholestatic liver diseases in dogs. Journal of Veterinary Internal Medicine, 20, (pp. 1085-1092) (8 p.).
Brinkhof, B., Spee, B., Rothuizen, J. & Penning, L.C. (2006). Development and evaluation of canine reference genes for accurate quantification of gene expression. Analytical Biochemistry, 356, (pp. 36-43) (8 p.).
Penning, L.C., Piek, C.J., Eib, D.W., Schipper, R.G., Holling, T.M. & Martens, G.J. (2006). Induction of apoptosis in hematopoietic cells with an antibody against tomoregulin-1. Anticancer Research, 26, (pp. 339-346) (8 p.).
IJzer, J., Roskams, T., Molenbeek, R.F., Ultee, A., Penning, L.C., Rothuizen, J. & van den Ingh, T.S.G.A.M. (2006). Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver. Comparative Hepatology, 5, (pp. 7) (1 p.).
Spee, B., Jonkers, M.D., Arends, B., Rutteman, G.R., Rothuizen, J. & Penning, L.C. (2006). Specific down-regulation of XIAP with RNA interference enhances the sensitivity of canine tumor cell-lines to TRAIL and doxorubicin. Molecular Cancer, 5 (34) (10 p.).
Spee, B., Arends, B., van den Ingh, T.S.G.A.M., Brinkhof, B., IJzer, J., Nederbragt, H., Penning, L.C. & Rothuizen, J. (2006). TGFB-1 signalling in canine hepatic diseases, new models for human fibrotic liver pathologies. Liver International, 26 (6), (pp. 716-725) (10 p.).
  Articles - 2005
Spee, B., Mandigers, P.J.J., Arends, B., Bode, P., van den Ingh, T.S.G.A.M., Hoffmann, G., Rothuizen, J. & Penning, L.C. (2005). Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman pinschers. Comparative Hepatology, 4 (3), (pp. 1-13) (14 p.).
Boomkens, S.Y., Slump, E., Egberink, H.F., Rothuizen, J. & Penning, L.C. (2005). PCR screening for candidate etiological agents of canine hepatitis. Veterinary Microbiology, 108 ((1-2)), (pp. 49-55) (7 p.).
Favier, R.P., Spee, B., Penning, L.C., Brinkhof, B. & Rothuizen, J. (2005). Quantitative PCR method to detect a 13-kb deletion in the MURR1 gene associated with copper toxicosis and HIV-1 replication. Mammalian Genome, 16, (pp. 460-463) (4 p.).
Spee, B., Penning, L.C., van den Ingh, T.S.G.A.M., Arends, B., IJzer, J., van Sluijs, F.J. & Rothuizen, J. (2005). Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatment. Comparative Hepatology, 4 (7), (pp. 1-11) (11 p.).
Boomkens, S.Y., de Rave, S., Pot, R.G., Egberink, H.F., Penning, L.C., Rothuizen, J., Zondervan, P.E. & Kusters, J.G. (2005). The role of helicobacter species in the pathogenesis of primary biliary cirrhosis and primary sclerosing cholangitis. FEMS Immunology and Medical Microbiology, 44 (2), (pp. 221-225) (5 p.).
  Articles - 2004
Mandigers, P.J.J., van den Ingh, T.S.G.A.M., Spee, B., Penning, L.C., Bode, P. & Rothuizen, J. (2004). Chronic hepatitis in Doberman pinschers. A review. Veterinary Quarterly, 26 (3), (pp. 99-106) (8 p.).
Boomkens, S.Y., Kusters, J.G., Hoffmann, G., Pot, R.G., Spee, B., Penning, L.C., Egberink, H.F., van den Ingh, T.S.G.A.M. & Rothuizen, J. (2004). Detection of Helicobacter pylori in bile of cats. FEMS Immunology and Medical Microbiology, 42, (pp. 307-311) (5 p.).
Boomkens, S Y, Penning, L C, Egberink, H F, van den Ingh, T S G A M & Rothuizen, J (2004). Hepatitis with special reference to dogs. A review on the pathogenesis and infectious etiologies, including unpublished results of recent own studies. Veterinary Quarterly, 26 (3), (pp. 107-114) (8 p.).
Boomkens, S.Y., Spee, B., IJzer, J., Kisjes, R., Egberink, H.F., van den Ingh, T.S.G.A.M., Rothuizen, J. & Penning, L.C. (2004). The establishment and characterization of the first canine hepatocellular carcinoma cell line, which resembles human oncogenic expression patterns. Comparative Hepatology, 3, (pp. 9) (1 p.).
  Articles - 2002
Michon, I.N., Penning, L.C., Molenaar, T.J.M., Biessen, E.A.L., van Berkel, T.J. & Kuiper, J.D. (2002). TGF-beta-like peptides and their effect on vascular smooth muscle cells in vitro. Biochemical and Biophysical Research Communications, 293, (pp. 1279-1286) (8 p.).
  Articles - 2000
Penning, L C, Denecker, G, Vercammen, D, Declercq, W, Schipper, R G & Vandenabeele, P (2000). A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines. Cytokine, 12 (6), (pp. 747-50) (4 p.). Copyright 2000 Academic Press..
Schipper, R G, Penning, L C & Verhofstad, A A (2000). Involvement of polyamines in apoptosis. Facts and controversies - effectors or protectors?. Seminars in Cancer Biology, 10 (1), (pp. 55-68) (14 p.).
  Articles - 1998
Penning, L C, Schipper, R G, Vercammen, D, Verhofstad, A A, Denecker, T, Beyaert, R & Vandenabeele, P (1998). Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines. Cytokine, 10 (6), (pp. 423-31) (9 p.). Copyright 1998 Academic Press Limited..
  Articles - 1997
Denecker, G, Vandenabeele, P, Grooten, J, Penning, L C, Declercq, W, Beyaert, R, Buurman, W A & Fiers, W (1997). Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. Cytokine, 9 (9), (pp. 631-8) (8 p.).
  Articles - 1995
Los, M, Van de Craen, M, Penning, L C, Schenk, H, Westendorp, M, Baeuerle, P A, Dröge, W, Krammer, P H, Fiers, W & Schulze-Osthoff, K (1995). Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature, 375 (6526), (pp. 81-3) (3 p.).
Fiers, W, Beyaert, R, Boone, E, Cornelis, S, Declercq, W, Decoster, E, Denecker, G, Depuydt, B, De Valck, D, De Wilde, G, Goossens, V, Grooten, J, Haegeman, G, Heyninck, K, Plaisance, S, Vancompernolle, K, Van Criekinge, W, Vandenabeele, P, Vanden Berghe, W, Van de Craen, M, Vandevoorde, V, Vercammen, D & Penning, Louis (01.01.1995). TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis. Journal of Inflammation, 47 (1-2), (pp. 67-75) (9 p.).
  Articles - 1994
Penning, L C & Dubbelman, T M (1994). Fundamentals of photodynamic therapy - cellular and biochemical aspects. Anti-Cancer Drugs, 5 (2), (pp. 139-46) (8 p.).
Penning, L C, Tijssen, K, VanSteveninck, J & Dubbelman, T M (1994). Hematoporphyrin derivative-induced photodynamic inhibition of Na+/K(+)-ATPase in L929 fibroblasts, Chinese hamster ovary cells and T24 human bladder transitional carcinoma cells. Photochemistry and Photobiology, 59 (3), (pp. 336-41) (6 p.).
Penning, L C, Tijssen, K, Boegheim, J P, van Steveninck, J & Dubbelman, T M (28.04.1994). Relationship between photodynamically induced damage to various cellular parameters and loss of clonogenicity in different cell types with hematoporphyrin derivative as sensitizer. Biochimica et Biophysica Acta, 1221 (3), (pp. 250-8) (9 p.).
Penning, L C, Lagerberg, J W, VanDierendonck, J H, Cornelisse, C J, Dubbelman, T M & VanSteveninck, J (01.11.1994). The role of DNA damage and inhibition of poly(ADP-ribosyl)ation in loss of clonogenicity of murine L929 fibroblasts, caused by photodynamically induced oxidative stress. Cancer Research, 54 (21), (pp. 5561-7) (7 p.).
  Articles - 1993
Penning, L C, Keirse, M J, VanSteveninck, J & Dubbelman, T M (1993). Ca(2+)-mediated prostaglandin E2 induction reduces haematoporphyrin-derivative-induced cytotoxicity of T24 human bladder transitional carcinoma cells in vitro. Biochemical Journal, 292 ( Pt 1), (pp. 237-40) (4 p.).
Penning, L C, VanSteveninck, J & Dubbelman, T M (16.08.1993). HPD-induced photodynamic changes in intracellular cyclic AMP levels in human bladder transitional carcinoma cells, clone T24. Biochemical and Biophysical Research Communications, 194 (3), (pp. 1084-9) (6 p.).
  Articles - 1992
Penning, L C, Rasch, M H, Ben-Hur, E, Dubbelman, T M, Havelaar, A C, Van der Zee, J & Van Steveninck, J (30.06.1992). A role for the transient increase of cytoplasmic free calcium in cell rescue after photodynamic treatment. Biochimica et Biophysica Acta, 1107 (2), (pp. 255-60) (6 p.).
Prinsze, C, Penning, L C, Dubbelman, T M & VanSteveninck, J (01.01.1992). Interaction of photodynamic treatment and either hyperthermia or ionizing radiation and of ionizing radiation and hyperthermia with respect to cell killing of L929 fibroblasts, Chinese hamster ovary cells, and T24 human bladder carcinoma cells. Cancer Research, 52 (1), (pp. 117-20) (4 p.).
  Articles - 1989
Van Haastert, P J, De Vries, M J, Penning, L C, Roovers, E, Van der Kaay, J, Erneux, C & Van Lookeren Campagne, M M (1989). Chemoattractant and guanosine 5'-[gamma-thio]triphosphate induce the accumulation of inositol 1,4,5-trisphosphate in Dictyostelium cells that are labelled with [3H]inositol by electroporation. Biochemical Journal, 258 (2), (pp. 577-86) (10 p.).
  Articles - 1988
De Wit, R J, van Bemmelen, M X, Penning, L C, Pinas, J E, Calandra, T D & Bonner, J T (1988). Studies of cell-surface glorin receptors, glorin degradation, and glorin-induced cellular responses during development of Polysphondylium violaceum. Experimental Cell Research, 179 (2), (pp. 332-43) (12 p.).
  Articles in volumes / proceedings - 2012
Smolders, L.A., Meij, B.P., Onis, D., Riemers, F.M., Bergknut, N., Wubbolts, R.W., Grinwis, G.C.M., Groot Koerkamp, M., Holstege, F.C., Hazewinkel, H.A.W., Creemers, L.B., Penning, L.C. & Tryfonidou, M.A. (2012). Gene expression profiling of naturally occurring early intervertebral disc degeneration suggests a crucial role of caveolin-1 in notochordal cell preservation. Proceedings European Veterinary Conference Voorjaarsdagen 2012 (pp. 236-237) (2 p.). European Veterinary Conference Voorjaarsdagen 2012, April 5-7, Amsterdam RAI, the Netherlands.
Smolders, L.A., Onis, D., Riemers, F.M., Penning, L.C., Bergknut, N., Kranenburg, H.C., Hazewinkel, H.A.W., Grinwis, G.C.M., Groot Koerkamp, M., Meij, B.P. & Tryfonidou, M.A. (2012). Gene expression profiling of naturally occurring early intervertebral disc degeneration. Abstract Book Spineweek 2012 (pp. 256) (1 p.). Spineweek 2012, 28 May-1 June, Amsterdam, Netherlands.
Smolders, L.A., Meij, B.P., Onis, D., Riemers, F.M., Bergknut, N., Wubbolts, R.W., Grinwis, G.C.M., Groot Koerkamp, M., Holstege, F.C., Hazewinkel, H.A.W., Creemers, L.B., Penning, L.C. & Tryfonidou, M.A. (2012). Identification of a novel biomolecular target for regeneration of the degenerated canine intervertebral disc. Proceedings 25th annual symposium of the European Society of Veterinary Neurology (ECVN) and European College of Veterinary Neurology (ESVN) (pp. 14-14) (1 p.). Annual symposium of the European Society of Veterinary Neurology (ECVN), September 13-15,Ghent, Belgium..
Bergknut, N., Rutges, J.P.H.J., van Tiel, J., Waarsing, H.J., Meij, B.P., Hazewinkel, H.A.W., Penning, L.C., Lagerstedt, A.S., Hagman, R., Creemers, L.B. & Dhert, W.J.A. (2012). Intervertebral disc regeneration in a rabbit annular puncture model using BMP-7 and Marimastat. Proceedings Annual Congress European Society and College of Veterinary Neurology (ECVS & ECVN) Annual Congress European Society and College of Veterinary Neurology (ECVS & ECVN), 13-15 September 2012, Ghent, Belgium..
  Articles in volumes / proceedings - 2007
Poldervaart, J.H., Favier, R.P., van den Ingh, T.S.G.A.M., Penning, L.C. & Rothuizen, J. (13.09.2007). Evaluation of prednisone treatment in canine idiopathic chronic hepatitis by using quantitative RT-PCR and immunochemistry. Evaluation of prednisone treatment in canine idiopathic chronic hepatitis by using quantitative RT-PCR and immunochemistry (pp. 221-222) (2 p.). 17th ECVIM-CA Congress.
Favier, R.P., Poldervaart, J.H., van den Ingh, T.S.G.A.M., Penning, L.C. & Rothuizen, J. (13.09.2007). Hepatitis in dogs: different forms and the role of prednisone treatment. Hepatitis in dogs: different forms and the role of prednisone treatment (pp. 120-122) (3 p.). 17th ECVIM-CA Congress.
Spee, B., Arends, B., Vankelecom, H., Rothuizen, J., Penning, L.C. & Roslams, T.A. (31.08.2007). Side-population analysis in healthy canine livers, a new source of liver specific progenitor cells?. Molecular Mechanisms of Regeneration / From Stem Cells to Organ Development, Function and Regeneration" FEBS Spetses International Summer School 2007.
  Articles in volumes / proceedings - 2005
Spee, B., Arends, B., van den Ingh, T.S.G.A.M., Brinkhof, B., Nederbragt, H., IJzer, J., Penning, L.C. & Rothuizen, J. (01.09.2005). Pathways of liver fibrosis and regeneration in the dog as a basis for new therapies. ECVIM-CA Congress Proceedings (pp. 179-181) (3 p.). 15th ECVIM-CA Congress, Glasgow, Scotland.
Kummeling, A., Rothuizen, J., Penning, L.C., Brinkhof, B. & van Sluijs, F.J. (01.09.2005). Prognostic factors for congenital portosystemic shunts based on gene expression profiles. ECVIM-CA Congress Proceedings (pp. 185-187) (3 p.). 15th ECVIM-CA Congress, Glasgow, Scotland.
Penning, L.C., Spee, B., Rothuizen, J. & Rutteman, G.R. (2005). Use of regenerative pathways by tumors ? Expression of oncogenes, tumor suppressor genes and gene products involved in cell- cell interactions in canine liver diseases. In G.R. Rutteman & L.C. Penning (Eds.), Tumor Cell Stromal Cell Interactions (pp. 5-6) (2 p.). Amsterdam, ESVONC precongress day of FECAVA/FEEVA/Voorjaarsdagen Congress april 14th 2005.
  Articles in volumes / proceedings - 2004
Penning, L.C. (09.09.2004). Regulation of genes involved in liver regeneration and fibrosis in dogs with acute and chronic hepatitis. Congress Proceedings, 14th ECVIM-CA Congress, 9th-11th september 2004,Barcelona, Spain (pp. 124-126) (3 p.). Barcelona, 14th ECVIN-CA Congress, 9th-11th september 2004, Barcelona, Spain.
Mandigers, P.J.J., van den Ingh, T.S.G.A.M., Spee, B., Penning, L.C. & Rothuizen, J. (2004). The pathogenesis of Doberman hepatitis. 14th Symposium ECVIM-CA (pp. 120-123) (4 p.). 14th Symposium ECVIM-CA.
  Awards - 0
L.C. Penning () NVH Science Retreat; Speed-date proposal prize: So you think you can repair the liver!
  Editorial activity - 0
L.C. Penning () BMC Molecular Biology [E]
L.C. Penning () BMC Veterinary Research [E]
  Contribution to the work of national or international committees and working groups - 0
L.C. Penning () Associate editor
L.C. Penning () Comittee Member
L.C. Penning () Editorial board
L.C. Penning () Editorial board
L.C. Penning () Editorial board
L.C. Penning () Editorial Board
L.C. Penning () Expertise Board Member
L.C. Penning () Expertise board member
L.C. Penning () Expertise member of Dutch Society for cell Biology
L.C. Penning () Member Editorial Board
L.C. Penning () Member of Editorial Board
L.C. Penning () Member of reviewing board
L.C. Penning () Organisation of hand-on course on Molecular biology for veterinary research
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Gegenereerd op 2017-11-20 07:08:43

Completed projects

Project:
Liver progenitor cells for functional recovery of liver disease 01.01.2010 to 01.01.2016
General project description

In both veterinary and human medicine, liver disease is difficult to treat. Even with a clear diagnosis many treatment options fail and there is no curative therapy available. The adult liver harbours a reserve population of cells, the liver stem or progenitor cells, that can repopulate the liver in case of severe or chronic injury. However, in many liver diseases this repair mechanisms is either too little or too late. Recent studies have shown a remarkable similarity between liver diseases of man and dog, not only in pathology but also in the reaction pattern of the progenitor cells upon liver damage. The research performed at the Department of Clinical Sciences of Companion Animals is focus on unraveling the mechanisms of liver progenitor cell activation. The ultimate goal is to target these intrinsic repair mechanisms and to accomplish functional recovery of liver disease using the patient’s own progenitor cells.


In dogs a congenital copper storage disease occurs, that results in chronic hepatitis and cirrhosis. This disease highly resembles Wilsons disease in man. New therapeutic strategies that arise from our research can quickly be applied to restore liver function in dogs with copper-induced liver injury. This will provide vital knowledge and expertise for translating new therapies to the human clinic (translational medicine). Our project therefore aims to bridge the gap between fundamental findings and clinical application in both veterinary and human medicine.

 
Role Researcher Funding
NWO grant: Translational adult stem cell research grant
Project members UU
Gegenereerd op 2017-11-20 07:08:43
Full name
dr. L.C. Penning Contact details
Prof. dr. H. Jakobgebouw

Yalelaan 108
Room -
3584 CM  UTRECHT
The Netherlands


Onbekend Gebouw

Onbekend 9999
Room -
9999 AA  ONBEKEND
The Netherlands


Phone number (direct) +31 30 253 1705
Gegenereerd op 2017-11-20 07:08:43
Last updated 03.02.2015