Dr. K. (Karin) Strijbis

Associate Professor
Infectious Diseases & Immunology
+31 30 253 4755
k.strijbis@uu.nl

Publications

2026

Scholarly publications

Chao, L., Alvarado-Melendez, E. I., Marougka, K., Wu, X., de Haan, C. A. M., Strijbis, K., & Wennekes, T. (2026). Development of a C5-Azidoacetamide-Modified 4-Amino-2,3-Difluorosialic Acid Activity-Based Probe for Labeling of Influenza A Neuraminidases. ChemBioChem, 27(6), Article e70288. [DOI] [Repository]

2025

Scholarly publications

Alvarado-Melendez, E. I., Ruessink, S. T., Strijbis, K., & Wennekes, T. (2025). Selective labeling and visualization of viral and bacterial neuraminidases using ortho-quinone methide-based probes. RSC Chemical Biology, 6(12), 1909-1919. [DOI] [Repository]
Segui-Perez, C., van Smoorenburg, M. Y., Maranus, A. E., Geijtenbeek, T. B. H., & Strijbis, K. (2025). Impact of bacterial vaginosis on sexually transmitted viral infections: a bacterial point of view. FEMS Microbiology Reviews, 49, Article fuaf039. [DOI] [Repository]
van Smoorenburg, M. Y., Nerwinska, J. L., van Hamme, J. L., Remmerswaal, E. B. M., Segui-Perez, C., Strijbis, K., & Geijtenbeek, T. B. H. (2025). Bacterial Vaginosis-Associated Prevotella timonensis Enhances Dendritic Cell-T Cell Clustering and Subsequent T Cell Proliferation. European Journal of Immunology, 55(9), 1-8. Article e70051. [DOI] [Repository]
Raymakers, L., Passchier, E. M., Verdonschot, M. E. L., Evers, M., Chan, C., Kuijpers, K. C., Raicu, G. M., Molenaar, I. Q., van Santvoort, H. C., Strijbis, K., Intven, M. P. W., Daamen, L. A., Leusen, J. H. W., & Olofsen, P. A. (2025). The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma. Cells, 14(9), Article 632. [DOI] [Repository]
van Smoorenburg, M. Y., Remmerswaal, E. B. M., Segui-Perez, C., van Hamme, J. L., Strijbis, K., & Geijtenbeek, T. B. H. (2025). Vaginal Prevotella timonensis Bacteria Enhance HIV-1 Uptake and Differentially Affect Transmission by Distinct Primary Dendritic Cell Subsets. European Journal of Immunology, 55(3), Article e202451192. [DOI] [Repository]
Segui-Perez, C., Huang, L. Z. X., Paganelli, F. L., Lievens, E., & Strijbis, K. (2025). Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function. Scientific Reports, 15(1), Article 8778. [DOI] [Repository]
Floor, E., Su, J., Chatterjee, M., Kuipers, E. S., Ijssennagger, N., Heidari, F., Giordano, L., Wubbolts, R. W., Mihaila, S. M., Stapels, D. A. C., Vercoulen, Y., & Strijbis, K. (2025). Development of a Caco-2-based intestinal mucosal model to study intestinal barrier properties and bacteria-mucus interactions. Gut Microbes, 17(1), 1-26. Article 2434685. [DOI] [Repository]

2024

Scholarly publications

Segui-Perez, C., de Jongh, R., Jonkergouw, R. L. W., Pelayo, P., Balskus, E. P., Zomer, A., & Strijbis, K. (2024). Prevotella timonensis degrades the vaginal epithelial glycocalyx through high fucosidase and sialidase activities. mBio, 15(9), Article e0069124. [DOI] [Repository]
van Teijlingen, NH., van Smoorenburg, MY., Sarrami-Forooshani, R., Zijlstra-Willems, EM., van Hamme, JL., Borgdorff, H., van de Wijgert, JHHM., van Leeuwen, E., van der Post, JAM., Strijbis, K., Ribeiro, CMS., & Geijtenbeek, TBH. (2024). Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4+ T Cells. Journal of Infectious Diseases, 230(1), e43-e47. [DOI] [Repository]
Peng, W., Giesbers, K., Siborova, M., Beugelink, W., Pronker, M., Schulte, D., Hilkens, J., Janssen, B., Strijbis, K., & Snijder, J. (2024). Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing. Life Science Alliance, 7(6), Article e202302366. [DOI] [Repository]
Segui-Perez, C., Stapels, D. A. C., Ma, Z., Su, J., Passchier, E., Westendorp, B., Wubbolts, R. W., Wu, W., van Putten, J. P. M., & Strijbis, K. (2024). MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C. Journal of Cell Science, 137(5). [DOI] [Repository]
Perez, C. S., Jongh, R. D., Jonkergouw, R., Pelayo, P., Balskus, E. P., Zomer, A., & Strijbis, K. (2024). Prevotella timonensis degrades the vaginal epithelial glycocalyx through high fucosidase and sialidase activities. (pp. 1-26). bioRxiv. [DOI]

2023

Scholarly publications

Peng, W., Giesbers, K. C. A. P., Šiborová, M., Beugelink, J. W., Pronker, M. F., Schulte, D., Hilkens, J., Janssen, B. J. C., Strijbis, K., & Snijder, J. (2023). Reverse engineering the anti-MUC1 hybridoma antibody 139H2 by mass spectrometry-based de novo sequencing. bioRxiv. [DOI] [Repository]
Mavrogeni, M. E., Asadpoor, M., Judernatz, J. H., van Ark, I., Wösten, M. M. S. M., Strijbis, K., Pieters, R. J., Folkerts, G., & Braber, S. (2023). Protective Effects of Alginate and Chitosan Oligosaccharides against Clostridioides difficile Bacteria and Toxin. Toxins, 15(10), 1-23. Article 586. [DOI]
Chatterjee, M., Huang, L. Z. X., Mykytyn, A. Z., Wang, C., Lamers, M. M., Westendorp, B., Wubbolts, R. W., van Putten, J. P. M., Bosch, B.-J., Haagmans, B. L., & Strijbis, K. (2023). Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface. PLoS Pathogens, 19(8), Article e1011571. [DOI] [Repository]
Madunić, K., Luijkx, Y. M. C. A., Mayboroda, O. A., Janssen, G. M. C., van Veelen, P. A., Strijbis, K., Wennekes, T., Lageveen-Kammeijer, G. S. M., & Wuhrer, M. (2023). O-glycomic and proteomic signatures of spontaneous and butyrate-stimulated colorectal cancer cell line differentiation. Molecular and Cellular Proteomics, 22(3), Article 100501. [DOI] [Repository]

2022

Scholarly publications

Segui-Perez, C., Stapels, D. A. C., Ma, Z., Su, J., Passchier, E., Westendorp, B., Wu, W., Putten, J. P. M. V., & Strijbis, K. (2022). MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C. (pp. 1-30). bioRxiv. [DOI] [Repository]
van Teijlingen, N. H., Helgers, L. C., Sarrami-Forooshani, R., Zijlstra-Willems, E. M., van Hamme, J. L., Segui-Perez, C., van Smoorenburg, M. Y., Borgdorff, H., van de Wijgert, J. H., van Leeuwen, E., van der Post, J. A., Strijbis, K., Ribeiro, C. M., & Geijtenbeek, T. B. (2022). Vaginal bacterium Prevotella timonensis turns protective Langerhans cells into HIV-1 reservoirs for virus dissemination. EMBO Journal, 41(19), 1-13. Article e110629. [DOI] [Repository]
Luijkx, Y. M. C. A., Henselijn, A. J., Bosman, G. P., Cramer, D. A. T., Giesbers, K. C. A. P., van 't Veld, E. M., Boons, G.-J., Heck, A. J. R., Reiding, K. R., Strijbis, K., & Wennekes, T. (2022). Detection of Bacterial α-l-Fucosidases with an Ortho-Quinone Methide-Based Probe and Mapping of the Probe-Protein Adducts. Molecules (Basel, Switzerland), 27(5), 1-15. Article 1615. [DOI] [Repository]

2021

Scholarly publications

Chatterjee, M., Huang, L. Z. X., Wang, C., Mykytyn, A. Z., Westendorp, B., Wubbolts, R. W., Bosch, B.-J., Haagmans, B. L., Putten, J. P. M. V., & Strijbis, K. (2021). The glycosylated extracellular domain of MUC1 protects against SARS-CoV-2 infection at the respiratory surface. bioRxiv. [DOI] [Repository]
Li, X., Wubbolts, R. W., Bleumink-Pluym, N. M. C., van Putten, J. P. M., & Strijbis, K. (2021). The transmembrane mucin muc1 facilitates b1-integrin-mediated bacterial invasion. mBio, 12(2), 1-16. Article e03491-20. [DOI] [Repository]
Luijkx, Y. M. C. A., Jongkees, S., Strijbis, K., & Wennekes, T. (2021). Development of a 1,2-difluorofucoside activity-based probe for profiling GH29 fucosidases. Organic & Biomolecular Chemistry, 19(13), 2968-2977. [DOI] [Repository]

2020

Scholarly publications

Chatterjee, M., van Putten, J. P. M., & Strijbis, K. (2020). Defensive Properties of Mucin Glycoproteins during Respiratory Infections-Relevance for SARS-CoV-2. mBio, 11(6), Article e02374-20. [DOI] [Repository]
Luijkx, Y., Bleumink, N., Jiang, J., Overkleeft, H. S., Wösten, M., Strijbis, K., & Wennekes, T. (2020). Bacteroides fragilis fucosidases facilitate growth and invasion of Campylobacter jejuni in the presence of mucins. Cellular Microbiology, 22(12), Article e13252. [DOI] [Repository]
van Teijlingen, N. H., Helgers, L. C., Zijlstra-Willems, E. M., van Hamme, J. L., Ribeiro, C. M. S., Strijbis, K., & Geijtenbeek, T. B. H. (2020). Vaginal dysbiosis associated-bacteria Megasphaera elsdenii and Prevotella timonensis induce immune activation via dendritic cells. Journal of Reproductive Immunology, 138, Article 103085. [DOI] [Repository]

2019

Scholarly publications

Li, X., Bleumink-Pluym, N. M. C., Luijkx, Y. M. C. A., Wubbolts, R. W., van Putten, J. P. M., & Strijbis, K. (2019). MUC1 is a receptor for the Salmonella SiiE adhesin that enables apical invasion into enterocytes. PLoS Pathogens, 15(2), Article e1007566. [DOI] [Repository]

2017

Scholarly publications

van Putten, J. P. M., & Strijbis, K. (2017). Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer. Journal of Innate Immunity, 9, 281-299. [DOI] [Repository]
Freitag, C. M., Strijbis, K., & van Putten, J. P. M. (2017). Host cell binding of the flagellar tip protein of Campylobacter jejuni. Cellular Microbiology, 19(6), Article e12714. [DOI] [Repository]

2016

Scholarly publications

Haapasalo-Tuomainen, K., Wollman, A., De Haas, C., Aerts, P., Van'T Veld, E., Strijbis, K., Wubbolts, R., Van Kessel, K., Leake, M., & Van Strijp, J. (2016). Characterization of the stoichiometry of the complex formed by Staphylococcal toxin LukSF and human C5a receptor. Immunobiology, 221(10), 1141. [DOI]

2015

Scholarly publications

Lin, M. Y., de Zoete, M. R., van Putten, J. P. M., & Strijbis, K. (2015). Redirection of Epithelial Immune Responses by Short-Chain Fatty Acids through Inhibition of Histone Deacetylases. Frontiers in Immunology [E], 6, 554. [DOI] [Repository]
Tafesse, F. G., Rashidfarrokhi, A., Schmidt, F. I., Freinkman, E., Dougan, S., Dougan, M., Esteban, A., Maruyama, T., Strijbis, K., & Ploegh, H. L. (2015). Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans. PLoS Pathogens, 11(10), Article e1005188. [DOI] [Repository]
Tillmann, A. T., Strijbis, K., Cameron, G., Radmaneshfar, E., Thiel, M., Munro, C. A., MacCallum, D. M., Distel, B., Gow, N. A. R., & Brown, A. J. P. (2015). Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicans. PLoS One, 10(6), e0126940. [DOI] [Repository]
Gkourtsa, A., van den Burg, J., Strijbis, K., Avula, T., Bijvoets, S., Timm, D., Hochstenbach, F., & Distel, B. (2015). Identification and characterization of Rvs162/Rvs167-3, a novel N-BAR heterodimer in the human fungal pathogen Candida albicans. Eukaryotic Cell, 182-193. [DOI] [Repository]

2014

Scholarly publications

Tafesse, F. G., Strijbis, K., & Ploegh, H. L. (2014). Quantitative Analysis of Cellular Diacylglycerol Content. Bio-protocol, 4(15). [DOI]
Strijbis, K., & Ploegh, H. L. (2014). Secretion of circular proteins using sortase. In A. I. Ivanov (Ed.), Exocytosis and Endocytosis (Second edition ed., Vol. II, pp. 73-83). (Methods in Molecular Biology; Vol. 1174). Humana Press. [DOI]
Strijbis, K., Yilmaz, O. H., Dougan, S. K., Esteban, A., Gröne, A., Kumamoto, C. A., & Ploegh, H. L. (2014). Intestinal Colonization by Candida albicans Alters Inflammatory Responses in Bruton's Tyrosine Kinase-Deficient Mice. PLoS One, 9(11), Article e112472. [DOI] [Repository]

2013

Scholarly publications

Strijbis, K., Tafesse, F. G., Fairn, G. D., Witte, M. D., Dougan, S. K., Watson, N., Spooner, E., Esteban, A., Vyas, V. K., Fink, G. R., Grinstein, S., & Ploegh, H. L. (2013). Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages. PLoS Pathogens, 9(6), e1003446. [DOI]
Reales-Calderón, J. A., Sylvester, M., Strijbis, K., Jensen, O. N., Nombela, C., Molero, G., & Gil, C. (2013). Candida albicans induces pro-inflammatory and anti-apoptotic signals in macrophages as revealed by quantitative proteomics and phosphoproteomics. Journal of Proteomics, 91, 106-135. [DOI]

2012

Scholarly publications

Strijbis, K., van den Burg, J., Visser, W. F., van den Berg, M., & Distel, B. (2012). Alternative splicing directs dual localization of Candida albicans 6-phosphogluconate dehydrogenase to cytosol and peroxisomes. FEMS Yeast Research, 12(1), 61-8. [DOI]
Strijbis, K., Spooner, E., & Ploegh, H. L. (2012). Protein ligation in living cells using sortase. Traffic, 13(6), 780-9. [DOI]

2011

Scholarly publications

McGehee, A. M., Strijbis, K., Guillen, E., Eng, T., Kirak, O., & Ploegh, H. L. (2011). Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production. PLoS One, 6(4), e18817. [DOI]
Esteban, A., Popp, M. W., Vyas, V. K., Strijbis, K., Ploegh, H. L., & Fink, G. R. (2011). Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages. Proceedings of the National Academy of Sciences of the United States of America, 108(34), 14270-5. [DOI]

2010

Scholarly publications

Strijbis, K., Vaz, F. M., & Distel, B. (2010). Enzymology of the carnitine biosynthesis pathway. IUBMB Life, 62(5), 357-62. [DOI]
Strijbis, K., van Roermund, C. W., van den Burg, J., van den Berg, M., Hardy, G. P. M., Wanders, R. J., & Distel, B. (2010). Contributions of carnitine acetyltransferases to intracellular acetyl unit transport in Candida albicans. Journal of Biological Chemistry, 285(32), 24335-46. [DOI]
Strijbis, K., & Distel, B. (2010). Intracellular acetyl unit transport in fungal carbon metabolism. Eukaryotic Cell, 9(12), 1809-15. [DOI]

2009

Scholarly publications

Strijbis, K., van Roermund, C. W. T., Hardy, G. P., van den Burg, J., Bloem, K., de Haan, J., van Vlies, N., Wanders, R. J. A., Vaz, F. M., & Distel, B. (2009). Identification and characterization of a complete carnitine biosynthesis pathway in Candida albicans. FASEB Journal, 23(8), 2349-59. [DOI]

2008

Scholarly publications

Strijbis, K., van Roermund, C. W. T., Visser, W. F., Mol, E. C., van den Burg, J., MacCallum, D. M., Odds, F. C., Paramonova, E., Krom, B. P., & Distel, B. (2008). Carnitine-dependent transport of acetyl coenzyme A in Candida albicans is essential for growth on nonfermentable carbon sources and contributes to biofilm formation. Eukaryotic Cell, 7(4), 610-8. [DOI]
Piekarska, K., Hardy, G., Mol, E., van den Burg, J., Strijbis, K., van Roermund, C., van den Berg, M., & Distel, B. (2008). The activity of the glyoxylate cycle in peroxisomes of Candida albicans depends on a functional beta-oxidation pathway: evidence for reduced metabolite transport across the peroxisomal membrane. Microbiology, 154(Pt 10), 3061-72. [DOI]