Dr. K. (Kerstin) Schneeberger-Verjaal

Dr. K. (Kerstin) Schneeberger-Verjaal

Assistant Professor
Internal Medicine of Companion Animals
+31 30 212 1800
k.schneeberger-verjaal@uu.nl

Publications

2025

Scholarly publications

Günther, D., Bergerbit, C., Marsee, A., Vedaraman, S., Pueyo-Moliner, A., Bastard, C., Eelen, G., Gerardo Nava, J. L., Dewerchin, M., Carmeliet, P., Kramann, R., Schneeberger, K., Spee, B., & De Laporte, L. (2025). Synergizing bioprinting and 3D cell culture to enhance tissue formation in printed synthetic constructs. Biofabrication, 17(2), Article 025015. https://doi.org/10.1088/1758-5090/adae37
https://research-portal.uu.nl/ws/files/255626279/G_nther_2025_Biofabrication_17_025015.pdf

2024

Scholarly publications

Sampaio da Silva, C., Boos, J. A., Goldowsky, J., Blache, M., Schmid, N., Heinemann, T., Netsch, C., Luongo, F., Boder-Pasche, S., Weder, G., Pueyo Moliner, A., Samsom, R.-A., Marsee, A., Schneeberger, K., Mirsaidi, A., Spee, B., Valentin, T., Hierlemann, A., & Revol, V. (2024). High-throughput platform for label-free sorting of 3D spheroids using deep learning. Frontiers in Bioengineering and Biotechnology, 12, 1-15. Article 1432737. https://doi.org/10.3389/fbioe.2024.1432737
https://research-portal.uu.nl/ws/files/249953854/fbioe-12-1432737.pdf
Ye, S., Marsee, A., van Tienderen, G. S., Rezaeimoghaddam, M., Sheikh, H., Samsom, R.-A., de Koning, E. J. P., Fuchs, S., Verstegen, M. M. A., van der Laan, L. J. W., van de Vosse, F., Malda, J., Ito, K., Spee, B., & Schneeberger, K. (2024). Accelerated production of human epithelial organoids in a miniaturized spinning bioreactor. Cell Reports Methods, 4(11), Article 100903. https://doi.org/10.1016/j.crmeth.2024.100903
https://research-portal.uu.nl/ws/files/245914948/1-s2.0-S2667237524002935-main.pdf
Wang, Z., Ye, S., van der Laan, L. J. W., Schneeberger, K., Masereeuw, R., & Spee, B. (2024). Chemically Defined Organoid Culture System for Cholangiocyte Differentiation. Advanced healthcare materials, 13(30), Article 2401511. https://doi.org/10.1002/adhm.202401511
https://research-portal.uu.nl/ws/files/248117278/Adv_Healthcare_Materials_-_2024_-_Wang_-_Chemically_Defined_Organoid_Culture_System_for_Cholangiocyte_Differentiation.pdf
Carpentier, N., Ye, S., Delemarre, M. D., Van der Meeren, L., Skirtach, A. G., van der Laan, L. J. W., Schneeberger, K., Spee, B., Dubruel, P., & Van Vlierberghe, S. (2024). Gelatin-Based Hybrid Hydrogels as Matrices for Organoid Culture. Biomacromolecules, 25(2), 590-604. https://doi.org/10.1021/acs.biomac.2c01496
http://@https://dspace.library.uu.nl/bitstream/handle/1874/435272/carpentier-et-al-2024-gelatin-based-hybrid-hydrogels-as-matrices-for-organoid-culture.pdf?sequence=1

2023

Scholarly publications

Bouwmeester, M. C., Tao, Y., Proença, S., van Steenbeek, F. G., Samsom, R.-A., Nijmeijer, S. M., Sinnige, T., van der Laan, L. J. W., Legler, J., Schneeberger, K., Kramer, N. I., & Spee, B. (2023). Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing. Molecules (Basel, Switzerland), 28(2), Article 621. https://doi.org/10.3390/molecules28020621
http://@https://dspace.library.uu.nl/bitstream/handle/1874/426917/molecules_28_00621_v3.pdf?sequence=1

2022

Scholarly publications

Willemse, J., van Tienderen, G., van Hengel, E., Schurink, I., van der Ven, D., Kan, Y., de Ruiter, P., Rosmark, O., Westergren-Thorsson G, G., Schneeberger, K., van der Eerden, B., Roest, H., Spee, B., van der Laan, L., de Jonge, J., & Verstegen, M. (2022). Hydrogels derived from decellularized liver tissue support the growth and differentiation of cholangiocyte organoids. Biomaterials, 284, 1-16. Article 121473. https://doi.org/10.1016/j.biomaterials.2022.121473
http://@https://dspace.library.uu.nl/bitstream/handle/1874/419840/1_s2.0_S0142961222001120_main.pdf?sequence=1

2021

Scholarly publications

Bouwmeester, M. C., Bernal, P. N., Oosterhoff, L. A., van Wolferen, M., Lehmann, V., Vermaas, M., Buchholz, M.-B., Peiffer, Q., Malda, J., van der Laan, L. J. W., Kramer, N. I., Schneeberger, K., Levato, R., & Spee, B. (2021). Bioprinting of Human Liver-derived Epithelial Organoids for Toxicity Studies. Macromolecular Bioscience, 21(12), 1-10. Article 2100327. https://doi.org/10.1002/mabi.202100327
http://@https://dspace.library.uu.nl/bitstream/handle/1874/418931/Macromolecular_Bioscience_2021_Bouwmeester_Bioprinting_of_Human_Liver_Derived_Epithelial_Organoids_for_Toxicity.pdf?sequence=1

2020

Scholarly publications

Schene, I. F., Ramos, R. J., van Vugt, A. H. M., Truong, H., van den Heuvel, D. J., Gerritsen, H. C., Houtkooper, R. H., van Weeghel, M., Middendorp, S., Mokry, M., Spee, B., Schneeberger, K., Nikkels, P. G. J., Huch, M., Clevers, H., Nieuwenhuis, E. E. S., van Hasselt, P. M., & Fuchs, S. A. (2020). Bipotent Liver Progenitors Depend on Glycolysis and Mitochondrial Pyruvate Oxidation for Stem Cell Functions. (SSRN). SSRN. https://doi.org/10.2139/ssrn.3564994
Schneeberger, K., Bouwmeester, M., Levato, R., Kramer, N., Malda, J., & Spee, B. (2020). BIOFABRICATION OF LIVER CONSTRUCTS FOR DRUG TOXICITY STUDIES. Drug Metabolism and Pharmacokinetics, 35(1), S8-S8. https://doi.org/10.1016/j.dmpk.2020.04.295
Ye, S., Boeter, J. W. B., Mihajlovic, M., van Steenbeek, F. G., van Wolferen, M. E., Oosterhoff, L. A., Marsee, A., Caiazzo, M., van der Laan, L. J. W., Penning, L. C., Vermonden, T., Spee, B., & Schneeberger, K. (2020). A Chemically Defined Hydrogel for Human Liver Organoid Culture. Advanced Functional Materials, 30(48), Article 2000893. https://doi.org/10.1002/adfm.202000893
http://@https://dspace.library.uu.nl/bitstream/handle/1874/428096/Adv_Funct_Materials_2020_Ye_A_Chemically_Defined_Hydrogel_for_Human_Liver_Organoid_Culture.pdf?sequence=1
Kramer, N., Pratscher, B., Meneses, A. M. C., Tschulenk, W., Walter, I., Swoboda, A., Kruitwagen, H. S., Schneeberger, K., Penning, L. C., Spee, B., Kieslinger, M., Brandt, S., & Burgener, I. A. (2020). Generation of Differentiating and Long-Living Intestinal Organoids Reflecting the Cellular Diversity of Canine Intestine. Cells, 9(4), Article 822. https://doi.org/10.3390/cells9040822
http://@https://dspace.library.uu.nl/bitstream/handle/1874/408080/cells_09_00822.pdf?sequence=1
Kruitwagen, H. S., Oosterhoff, L. A., van Wolferen, M. E., Chen, C., Nantasanti Assawarachan, S., Schneeberger, K., Kummeling, A., van Straten, G., Akkerdaas, I. C., Vinke, C. R., van Steenbeek, F. G., van Bruggen, L. W. L., Wolfswinkel, J., Grinwis, G. C. M., Fuchs, S. A., Gehart, H., Geijsen, N., Vries, R. G., Clevers, H., ... Spee, B. (2020). Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease. Cells, 9(2), 1-16. Article 410. https://doi.org/10.3390/cells9020410
http://@https://dspace.library.uu.nl/bitstream/handle/1874/408039/cells_09_00410_v2.pdf?sequence=1
Schneeberger, K., Sánchez-Romero, N., Ye, S., van Steenbeek, F. G., Oosterhoff, L. A., Pla Palacin, I., Chen, C., van Wolferen, M. E., van Tienderen, G., Lieshout, R., Colemonts-Vroninks, H., Schene, I., Hoekstra, R., Verstegen, M. M. A., van der Laan, L. J. W., Penning, L. C., Fuchs, S. A., Clevers, H., De Kock, J., ... Spee, B. (2020). Large-scale Production of LGR5-positive Bipotential Human Liver Stem Cells. Hepatology, 72(1), 257-270. https://doi.org/10.1002/hep.31037
http://@https://dspace.library.uu.nl/bitstream/handle/1874/432725/large_scale_production_of_lgr5_positive.21.pdf?sequence=1

2019

Scholarly publications

Ye, S., Boeter, J. W. B., Penning, L. C., Spee, B., & Schneeberger, K. (2019). Hydrogels for Liver Tissue Engineering. Bioengineering (Basel, Switzerland), 6(3), Article 59. https://doi.org/10.3390/bioengineering6030059
http://@https://dspace.library.uu.nl/bitstream/handle/1874/384916/bioengineering_06_00059.pdf?sequence=1

2018

Scholarly publications

Schneeberger, K., Roth, S., Nieuwenhuis, E. E. S., & Middendorp, S. (2018). Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease. Disease Models & Mechanisms, 11(2). https://doi.org/10.1242/dmm.031088
Chen, C., Jochems, P., Salz, L., Schneeberger, K., Penning, L. C., van de Graaf, S. F. J., Beuers, U., Clevers, H., Geijsen, N., Masereeuw, R., & Spee, B. (2018). Bioengineered bile ducts recapitulate key cholangiocyte functions. Biofabrication, 10(3), Article 034103. https://doi.org/10.1088/1758-5090/aac8fd
http://@https://dspace.library.uu.nl/bitstream/handle/1874/369772/Chen_2018_Biofabrication_10_034103.pdf?sequence=1

2017

Scholarly publications

Schneeberger, K., Spee, B., Costa, P., Sachs, N., Clevers, H., & Malda, J. (2017). Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering? Biofabrication, 9, Article 013001. https://doi.org/10.1088/1758-5090/aa6121
http://@https://dspace.library.uu.nl/bitstream/handle/1874/360389/Schneeberger_2017_Biofabrication_9_013001.pdf?sequence=1

2016

Scholarly publications

Meneses, A. M. C., Schneeberger, K., Kruitwagen, H. S., Penning, L. C., van Steenbeek, F. G., Burgener, I. A., & Spee, B. (2016). Intestinal Organoids-Current and Future Applications. Veterinary Sciences, 3(4). https://doi.org/10.3390/vetsci3040031
Meneses, A., Schneeberger, K., Kruitwagen, H., Penning, L., van Steenbeek, F., Burgener, I., & Spee, B. (2016). Intestinal Organoids—Current and Future Applications. Veterinary Sciences, 3(4), 31. https://doi.org/10.3390/vetsci3040031
http://@https://dspace.library.uu.nl/bitstream/handle/1874/351013/Intestinal.pdf?sequence=1
van Rijn, J. M., Schneeberger, K., Wiegerinck, C. L., Nieuwenhuis, E. E. S., & Middendorp, S. (2016). Novel approaches: Tissue engineering and stem cells--In vitro modelling of the gut. Best Practice & Research in Clinical Gastroenterology, 30(2), 281-293. https://doi.org/10.1016/j.bpg.2016.03.005
http://@https://dspace.library.uu.nl/bitstream/handle/1874/345992/14_main.pdf?sequence=1

2015

Scholarly publications

Schneeberger, K., Vogel, G. F., Teunissen, H., van Ommen, D. D., Begthel, H., El Bouazzaoui, L., van Vugt, A. H. M., Beekman, J. M., Klumperman, J., Müller, T., Janecke, A., Gerner, P., Huber, L. A., Hess, M. W., Clevers, H., van Es, J. H., Nieuwenhuis, E. E. S., & Middendorp, S. (2015). An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking. Proceedings of the National Academy of Sciences of the United States of America, 112(40), 12408-13. https://doi.org/10.1073/pnas.1516672112
http://@https://dspace.library.uu.nl/bitstream/handle/1874/341088/inducible.pdf?sequence=1

2014

Scholarly publications

Brugman, S., Schneeberger, K., Witte, M., Klein, M. R., van den Bogert, B., Boekhorst, J., Timmerman, H. M., Boes, M. L., Kleerebezem, M., & Nieuwenhuis, E. E. S. (2014). T lymphocytes control microbial composition by regulating the abundance of Vibrio in the zebrafish gut. Benef Microbes, 5(6), 737-47. https://doi.org/10.4161/19490976.2014.972228
Middendorp, S., Schneeberger, K., Wiegerinck, C. L., Mokry, M., Akkerman, R. D. L., van Wijngaarden, S., Clevers, H., & Nieuwenhuis, E. E. S. (2014). Adult stem cells in the small intestine are intrinsically programmed with their location-specific function. Stem Cells, 32(5), 1083-91. https://doi.org/10.1002/stem.1655

2012

Scholarly publications

de Lau, W., Kujala, P., Schneeberger, K., Middendorp, S., Li, V. S. W., Barker, N., Martens, A., Hofhuis, F., DeKoter, R. P., Peters, P. J., Nieuwenhuis, E., & Clevers, H. (2012). Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". Molecular and Cellular Biology, 32(18), 3639-47. https://doi.org/10.1128/MCB.00434-12
Bernardes de Jesus, B., Vera, E., Schneeberger, K., Tejera, A. M., Ayuso, E., Bosch, F., & Blasco, M. A. (2012). Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Journal, 4(8), 691-704. https://doi.org/10.1002/emmm.201200245

2011

Scholarly publications

Bernardes de Jesus, B., Schneeberger, K., Vera, E., Tejera, A., Harley, C. B., & Blasco, M. A. (2011). The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell, 10(4), 604-21. https://doi.org/10.1111/j.1474-9726.2011.00700.x