dr. K. (Klaartje) Houben
Gegenereerd op 2017-11-18 18:39:10


As scientific supervisor of the uNMR-NL consortium, I am responsible for the 950MHz spectrometer that will be installed at Utrecht University in 2015. Peer-reviewed access to this spectrometer will be provided to research institutions as well as companies in the Netherlands. In addition I am facility manager of the Utrecht NMR facility that provides access to both Dutch and European scientists.

My research focusses on the study of the structure and dynamics of membrane proteins with NMR.

Involved in the following study programme(s)
Gegenereerd op 2017-11-18 18:39:10
Curriculum vitae Download PDF
Gegenereerd op 2017-11-18 18:39:10
All publications
  2016 - Scholarly publications
Medeiros-Silva, João, Mance, Deni, Daniëls, Mark, Jekhmane, Miranda, Houben, Klaartje, Baldus, Marc & Weingarth, Markus (17.10.2016). 1H-Detected Solid-State NMR Studies of Water-Inaccessible Proteins In Vitro and In Situ. Angewandte Chemie-International Edition, 55 (43), (pp. 13606-13610) (5 p.).
Huculeci, Radu, Cilia, Elisa, Lyczek, Agatha, Buts, Lieven, Houben, Klaartje, Seeliger, Markus A, van Nuland, Nico & Lenaerts, Tom (28.09.2016). Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure with Folding & design, 24 (11), (pp. 1947–1959) (13 p.). Copyright © 2016 Elsevier Ltd. All rights reserved..
Kaplan, M., Narasimhan, Siddarth, de Heus, Cilia, Mance, Deni, van Doorn, Sander, Houben, Klaartje, Popov-Celeketic, Dusan, Damman, Reinier, Katrukha, Eugene A, Jain, Purvi, Geerts, Willie J C, Heck, Albert J R, Folkers, Gert E, Kapitein, Lukas C, Lemeer, Simone, van Bergen En Henegouwen, Paul M P & Baldus, Marc (17.11.2016). EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR. Cell, 167 (5), (pp. 1241-1251.e11) (11 p.). Copyright © 2016 Elsevier Inc. All rights reserved..
Chowdhury, Abhishek Dutta, Houben, Klaartje, Whiting, Gareth T, Mokhtar, Mohamed, Asiri, Abdullah M, Al-Thabaiti, Shaeel A, Basahel, Suliman N, Baldus, Marc & Weckhuysen, Bert M (19.12.2016). Initial Carbon-Carbon Bond Formation during the Early Stages of the Methanol-to-Olefin Process Proven by Zeolite-Trapped Acetate and Methyl Acetate. Angewandte Chemie-International Edition, 55 (51), (pp. 15840-15845) (6 p.). © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA..
Kaplan, M., de Agrela Pinto, Cecilia, Houben, Klaartje & Baldus, Marc (2016). Nuclear magnetic resonance (NMR) applied to membrane-protein complexes. Quarterly Reviews of Biophysics, 49.
Chung, Sangho, Angelici, Carlo, Hinterding, Stijn O. M., Weingarth, Markus, Baldus, Marc, Houben, Klaartje, Weckhuysen, Bert M. & Bruijnincx, Pieter C. A. (2016). Role of Magnesium Silicates in Wet-Kneaded Silica-Magnesia Catalysts for the Lebedev Ethanol-to-Butadiene Process. ACS Catalysis, 6 (6), (pp. 4034-4045) (12 p.).
Yarulina, Irina, Bailleul, Simon, Pustovarenko, Alexey, Martinez, Javier Ruiz, Wispelaere, Kristof De, Hajek, Julianna, Weckhuysen, Bert M., Houben, Klaartje, Baldus, Marc, Van Speybroeck, Veronique, Kapteijn, Freek & Gascon, Jorge (06.10.2016). Suppression of the Aromatic Cycle in Methanol-to-Olefins Reaction over ZSM-5 by Post-Synthetic Modification Using Calcium. ChemCatChem, 8 (19), (pp. 3057-3063) (7 p.).
  2015 - Scholarly publications
Mance, Deni, Sinnige, Tessa, Kaplan, M., Narasimhan, Siddarth, Daniëls, Mark, Houben, Klaartje, Baldus, Marc & Weingarth, Markus (2015). An Efficient Labelling Approach to Harness Backbone and Side-Chain Protons in 1H-Detected Solid-State NMR Spectroscopy. Angewandte Chemie-International Edition, 54 (52), (pp. 15799-15803) (5 p.).
Sinnige, Tessa, Weingarth, Markus, Daniels, Mark, Boelens, Rolf, Bonvin, Alexandre M. J. J., Houben, Klaartje & Baldus, Marc (07.07.2015). Conformational Plasticity of the POTRA 5 Domain in the Outer Membrane Protein Assembly Factor BamA. Structure with Folding & design, 23 (7), (pp. 1317-1324) (8 p.).
Sinnige, Tessa, Houben, Klaartje, Pritisanac, Iva, Renault, Marie, Boelens, Rolf & Baldus, Marc (2015). Insight into the conformational stability of membrane-embedded BamA using a combined solution and solid-state NMR approach. Journal of Biomolecular NMR, 61 (3-4), (pp. 321-32) (12 p.).
Baker, Lindsay A., Folkers, Gert E., Sinnige, Tessa, Houben, Klaartje, Kaplan, M., van der Cruijsen, Elwin A W & Baldus, Marc (01.01.2015). Magic-Angle-Spinning Solid-State NMR of Membrane Proteins. Methods in Enzymology, 557, (pp. 307-328) (22 p.).
  2010 - Scholarly publications
Jensen, Malene Ringkjøbing, Bernadó, Pau, Houben, Klaartje, Blanchard, Laurence, Marion, Dominque, Ruigrok, Rob W. H. & Blackledge, Martin (30.04.2010). Structural disorder within sendai virus nucleoprotein and phosphoprotein: Insight into the structural basis of molecular recognition. Protein and Peptide Letters, 17 (8), (pp. 952-960) (9 p.).
  2008 - Scholarly publications
Jensen, Malene Ringkjøbing, Houben, Klaartje, Lescop, Ewen, Blanchard, Laurence, Ruigrok, Rob W. H. & Blackledge, Martin (25.06.2008). Quantitative conformational analysis of partially folded proteins from residual dipolar couplings: Application to the molecular recognition element of Sendai virus nucleoprotein. Journal of the American Chemical Society, 130 (25), (pp. 8055-8061) (7 p.).
  2007 - Scholarly publications
Houben, Klaartje, Marion, Dominique, Tarbouriech, Nicolas, Ruigrok, Rob W. H. & Blanchard, Laurence (01.07.2007). Interaction of the C-terminal domains of sendai virus N and P proteins: Comparison of polymerase-nucleocapsid interactions within the paramyxovirus family. Journal of Virology, 81 (13), (pp. 6807-6816) (10 p.).
Houben, Klaartje, Blanchard, Laurence, Blackledge, Martin & Marion, Dominique (01.10.2007). Intrinsic dynamics of the partly unstructured PX domain from the Sendai Virus RNA polymerase cofactor P. Biophysical Journal, 93 (8), (pp. 2830-2844) (15 p.).
Pannetier, Nicolas, Houben, Klaartje, Blanchard, Laurence & Marion, Dominique (01.05.2007). Optimized 3D-NMR sampling for resonance assignment of partially unfolded proteins. Journal of Magnetic Resonance, 186 (1), (pp. 142-149) (8 p.).
  2005 - Scholarly publications
Houben, Klaartje, Wasielewski, Emeric, Dominguez, Cyril, Kellenberger, Esther, Atkinson, R. Andrew, Timmers, H. Th. Marc, Kieffer, Bruno & Boelens, Rolf (10.06.2005). Dynamics and metal exchange properties of C4C4 RING domains from CNOT4 and the p44 subunit of TFIIH. Journal of Molecular Biology, 349 (3), (pp. 621-637) (17 p.).
Bernard, C., Houben, K., Derix, N.M., Marks, D.R.A., van der Horst, M.A., Hellingwerf, K.J., Boelens, R., Kaptein, R. & van Nuland, N.A.J. (2005). The solution structure of a transient photoreceptor intermediate: Δ25-Photoactive Yellow Protein. Structure with Folding & design, 13, (pp. 953-962) (10 p.).
  2004 - Scholarly publications
Houben, K. & Boelens, R. (2004). Side chain dynamics monitored by 13C-13C cross-relaxation. Journal of Biomolecular NMR, 29, (pp. 151-166) (16 p.).
Houben, K., Dominguez, C., van Schaik, F.M.A., Timmers, H.T.M., Bonvin, A.M.J.J. & Boelens, R. (2004). Solution structure of the ubiquitin-conjugating enzyme UbcH5B. Journal of Molecular Biology, 344, (pp. 513-526) (14 p.).
  2001 - Scholarly publications
Bonvin, A.M.J.J., Houben, K., Guenneugues, M.N.L., Kaptein, R. & Boelens, R. (2001). Rapid protein fold determination using secondary chemical shifts and cross-hydrogen bond 15N-13C’ scalar couplings (3hbJNC’). Journal of Biomolecular NMR, 21 (3), (pp. 221-233) (13 p.).
^ top
Gegenereerd op 2017-11-18 18:39:10
01.06.2013 to 30.06.2021
General project description 

The project uNMR-NL was awarded 18,5 million euro from NWO to be established as a large-scale research facility for ultra-high field NMR spectroscopy (1.2 GHz). In the new uNMR-NL facility, researchers will use magnetic nuclear resonance (NMR) and MR Imaging (MRI) to study the origin of diseases like Alzheimer’s and Parkinson’s, to identify new potential drugs, to develop new materials for batteries and solar cells and to enhance the production of crops and food quality. The project is coordinated by prof. Marc Baldus of Utrecht University and also involves the Radboud University NIjmegen, Leiden University, Wageningen University,  Eindhoven University of Technology and the public-private partnership for the analytical sciences, COAST.

Role Researcher Funding
NWO grant
Project members UU
External project members:
  • prof. dr. Arno Kentgens (RU)
  • prof. dr. Marcellus Ubbink (LU)
  • prof. dr. Huub de Groot (LU)
  • prof. dr. John van Duynhoven (WUR)
  • prof. dr. Aldrik Velders (WUR)
  • dr. Henk van As (WUR)
  • Klaas Nicolay (TU/e)
  • Oscar van den Brink (COAST)

Gegenereerd op 2017-11-18 18:39:10
Additional functions and activities

I am member of the diversity committee of the faculty of sciences

Gegenereerd op 2017-11-18 18:39:10
Full name
dr. K. Houben Contact details
Mo Tue Wed Thu Fr

Visiting address: 
Nicolaas Bloembergengebouw, room 1.20
Padualaan 8, 3584 CH Utrecht
Accessible via Kruyt Building -> first floor -> bridge to Sjoerd Groenman Building

Postal address:
Universiteit Utrecht, NMR
Padualaan 8, 3584 CH Utrecht

: +31 30 253 9940

Phone (secr): +31 30 253 2652

Gegenereerd op 2017-11-18 18:39:10
Last updated 31.10.2017