Dr. ing. J. (Javier) Sastre Torano

David de Wiedgebouw
Universiteitsweg 99
Kamer 5.66
3584 CG Utrecht

Dr. ing. J. (Javier) Sastre Torano

Research and Education Assistant
Chemical Biology and Drug Discovery
+31 6 20 251 516
j.sastretorano@uu.nl

Publications

2023

Scholarly publications

Vos, G. M., Hooijschuur, K. C., Li, Z., Fjeldsted, J., Klein, C., de Vries, R. P., Toraño, J. S., & Boons, G-J. (2023). Sialic acid O-acetylation patterns and glycosidic linkage type determination by ion mobility-mass spectrometry. Nature Communications, 14(1), 6795. Advance online publication. https://doi.org/10.1038/s41467-023-42575-x
Vos, G. M., Weber, J., Sweet, I. R., Hooijschuur, K. C., Sastre Toraño, J., & Boons, G-J. (2023). Oxidative Release of O-Glycans under Neutral Conditions for Analysis of Glycoconjugates Having Base-Sensitive Substituents. Analytical Chemistry, 95(23), 8825-8833. https://doi.org/10.1021/acs.analchem.3c00127
Hooijschuur, K., Liu, X., Grootendorst, A., Pieterman, I., & Sastre Toraño, J. (2023). In-line sample trap columns with diatomite for large-volume injection in CZE–IM–MS. Electrophoresis, 44(3-4), 395-402. https://doi.org/10.1002/elps.202200189

2021

Scholarly publications

Zaree, P., Torano, J. S., de Haan, C. A. M., Scheltma, R. A., Barendregt, A., Thijssen, V., Yu, G., Flesch, F., & Pieters, R. J. (2021). The assessment of Pseudomonas aeruginosa lectin LecA binding characteristics of divalent galactosides using multiple techniques. Glycobiology, 31(11), 1490-1499. https://doi.org/10.1093/glycob/cwab074
Bosman, G., Oliviera, S., Simons, P., Sastre Torano, J., Somsen, G. W., Knippels, L., Haselberg, R., Pieters, R., Garssen, J., & Knipping, K. (2021). Limited Lactosylation of Beta-Lactoglobulin from Cow’s Milk Exerts Strong Influence on Antigenicity and Degranulation of Mast Cells. Nutrients, 13(6), 1-13. Article 2041. https://doi.org/10.3390/nu13062041
Rood, J. J. M., Toraño, J. S., Somovilla, V. J., Beijnen, J. H., & Sparidans, R. W. (2021). Bioanalysis of erlotinib, its O-demethylated metabolites OSI-413 and OSI-420, and other metabolites by liquid chromatography-tandem mass spectrometry with additional ion mobility identification. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1166, Article 122554. https://doi.org/10.1016/j.jchromb.2021.122554
Güngör, E., Brouwer, P., Dijkhuizen, L. W., Shaffar, D. C., Nierop, K. G. J., Vos, R. C. H., Sastre Toraño, J., Meer, I. M., & Schluepmann, H. (2021). Azolla ferns testify: seed plants and ferns share a common ancestor for leucoanthocyanidin reductase enzymes. New Phytologist, 229(2), 1118-1132. https://doi.org/10.1111/nph.16896
Sastre Toraño, J., Aizpurua-Olaizola, O., Wei, N., Li, T., Unione, L., Jiménez-Osés, G., Corzana, F., Somovilla, V. J., Falcon-Perez, J. M., & Boons, G-J. (2021). Identification of Isomeric N-glycans by Conformer Distribution Fingerprinting using Ion Mobility-Mass Spectrometry. Chemistry-A European Journal, 27(6), 2149-2154. https://doi.org/10.1002/chem.202004522

2020

Scholarly publications

Sastre Torano, J. (2020). Analysis of Glycans by Electrophoretic Approaches: Highly Sensitive Capillary Electrophoretic Separation and Ion Mobility-Mass Spectrometric Structure Assignment. [Doctoral thesis 1 (Research UU / Graduation UU), Universiteit Utrecht]. Utrecht University. https://doi.org/10.33540/64
Liu, Y., Scrivano, L., Peterson, J. D., Fens, M. H. A. M., Beltrán Hernández, I., Mesquita, B., Sastre Torano, J., Hennink, W. E., van Nostrum, C. F., & Oliveira, S. (2020). EGFR targeted nanobody functionalized polymeric micelles loaded with mTHPC for selective photodynamic therapy. Molecular Pharmaceutics. https://doi.org/10.1021/acs.molpharmaceut.9b01280

2019

Scholarly publications

Sastre Toraño, J., Ramautar, R., & de Jong, G. (2019). Advances in capillary electrophoresis for the life sciences. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1118-1119, 116-136. https://doi.org/10.1016/j.jchromb.2019.04.020
Sastre Toraño, J., Gagarinov, I. A., Vos, G. M., Broszeit, F., Srivastava, A. D., Palmer, M., Langridge, J. I., Aizpurua-Olaizola, O., Somovilla, V. J., & Boons, G-J. (2019). Ion-Mobility Spectrometry Can Assign Exact Fucosyl Positions in Glycans and Prevent Misinterpretation of Mass-Spectrometry Data After Gas-Phase Rearrangement. Angewandte Chemie-International Edition, 58(49), 17616-17620. https://doi.org/10.1002/anie.201909623
De Groof, T. W. M., Mashayekhi, V., Fan, T. S., Bergkamp, N. D., Toraño, J. S., Van Senten, J. R., Heukers, R., Smit, M. J., & Oliveira, S. (2019). Nanobody-Targeted Photodynamic Therapy Selectively Kills Viral GPCR-Expressing Glioblastoma Cells. Molecular pharmaceutics, 16(7), 3145-3156. https://doi.org/10.1021/acs.molpharmaceut.9b00360
Jansen, J., Jansen, K., Neven, E., Poesen, R., Othman, A., van Mil, A., Sluijter, J., Sastre Torano, J., Zaal, E. A., Berkers, C. R., Esser, D., Wichers, H. J., van Ede, K., van Duursen, M., Burtey, S., Verhaar, M. C., Meijers, B., & Masereeuw, R. (2019). Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion. Proceedings of the National Academy of Sciences of the United States of America, 116(32), 16105-16110. https://doi.org/10.1073/pnas.1821809116
Boons, G-J., Gagarinov, I. A., Li, T., Wei, N., Sastre Toraño, J., de Vries, R. P., & Wolfert, M. A. (2019). Protecting Group-Controlled Enzymatic Glycosylation of Oligo-N-Acetyllactosamine Derivatives. Angewandte Chemie-International Edition, 58(31), 10547-10552. https://doi.org/10.1002/anie.201903140
Shi, H., Leonhard, W. N., Sijbrandi, N. J., van Steenbergen, M. J., Fens, M. H. A. M., van de Dikkenberg, J. B., Toraño, J. S., Peters, D. J. M., Hennink, W. E., & Kok, R. J. (2019). Folate-dactolisib conjugates for targeting tubular cells in polycystic kidneys. Journal of controlled release : official journal of the Controlled Release Society, 293, 113-125. https://doi.org/10.1016/j.jconrel.2018.11.019

Professional publications

van der Made, T. K., Fedecostante, M., Scotcher, D., Rostami-Hodjegan, A., Sastre Toraño, J., Middel, I., Koster, A. S., Gerritsen, K. G., Jankowski, V., Jankowski, J., Hoenderop, J. G. J., Masereeuw, R., & Galetin, A. (2019). Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. Molecular Pharmaceutics, 16, 4551-4562. https://doi.org/10.1021/acs.molpharmaceut.9b00681

2018

Scholarly publications

Chevtchik, N. V., Mihajlovic, M., Fedecostante, M., Bolhuis-Versteeg, L., Sastre Toraño, J., Masereeuw, R., & Stamatialis, D. (2018). A bioartificial kidney device with polarized secretion of immune modulators. Journal of Tissue Engineering and Regenerative Medicine, 12(7), 1670–1678. https://doi.org/10.1002/term.2694
Martínez-Jothar, L., Doulkeridou, S., Schiffelers, R. M., Torano, J. S., Oliveira, S., van Nostrum, C. F., & Hennink, W. E. (2018). Insights into maleimide - thiol conjugation chemistry: conditions for efficient surface functionalization of nanoparticles for receptor targeting. Journal of Controlled Release, 282, 101-109. https://doi.org/10.1016/j.jconrel.2018.03.002
https://dspace.library.uu.nl/bitstream/handle/1874/376473/Insights.pdf?sequence=1
Aizpurua-Olaizola, O., Sastre Toraño, J., Falcon-Perez, J. M., Williams, C., Reichardt, N-C., & Boons, G. J. (2018). Mass spectrometry for glycan biomarker discovery. TrAC - Trends in Analytical Chemistry, 100, 7-14. https://doi.org/10.1016/j.trac.2017.12.015
Kordalivand, N., Li, D., Beztsinna, N., Sastre Torano, J., Mastrobattista, E., van Nostrum, C. F., Hennink, W. E., & Vermonden, T. (2018). Polyethyleneimine coated nanogels for the intracellular delivery of RNase A for cancer therapy. Chemical Engineering Journal, 340, 32-41. https://doi.org/10.1016/j.cej.2017.12.071
Aizpurua-Olaizola, O., Sastre Torano, J., Pukin, A., Fu, O., Boons, G. J., de Jong, G. J., & Pieters, R. J. (2018). Affinity capillary electrophoresis for the assessment of binding affinity of carbohydrate-based cholera toxin inhibitors. Electrophoresis, 39(2), 344–347. https://doi.org/10.1002/elps.201700207

2017

Scholarly publications

Kleijn, L. H. J., Vlieg, H. C., Wood, T. M., Sastre Torano, J., Janssen, B. J. C., & Martin, N. I. (2017). A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycin C. Angewandte Chemie-International Edition, 56(52), 16546-16549. https://doi.org/10.1002/anie.201709240
Sevsek, A., Sastre Toraño, J., Quarles Van Ufford, L., Moret, E. E., Pieters, R. J., & Martin, N. I. (2017). Orthoester functionalized: N -guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase. MedChemComm, 8(11), 2050-2054. https://doi.org/10.1039/c7md00480j
Mackus, M., van de Loo, A. J. A. E., Raasveld, S. J., Hogewoning, A., Sastre Toraño, J., Flesch, F. M., Korte-Bouws, G. A. H., van Neer, R. H. P., Wang, X., Nguyen, T. T., Brookhuis, K. A., Kraneveld, A. D., Garssen, J., & Verster, J. C. (2017). Biomarkers of the alcohol hangover state: Ethyl glucuronide (EtG) and ethyl sulfate (EtS). Human Psychopharmacology, 32(5), Article 2624. https://doi.org/10.1002/hup.2624
van Haren, M. J., Taig, R., Kuppens, J., Sastre Toraño, J., Moret, E. E., Parsons, R. B., Sartini, D., Emanuelli, M., & Martin, N. I. (2017). Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state. Organic and Biomolecular Chemistry, 15(31), 6656-6667. https://doi.org/10.1039/c7ob01357d
Gagarinov, I. A., Li, T., Sastre Torano, J., Caval, T., Srivastava, A. D., Kruijtzer, J. A. W., Heck, A. J. R., & Boons, G-J. (2017). A Chemoenzymatic Approach for the Preparation of Asymmetric Bi-, Tri- and Tetra-Antennary N-Glycans from a Common Precursor. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.6b12080

2016

Scholarly publications

Van De Loo, A. J. A. E., Van Neer, R. H. P., Wang, X., Nguyen, T. T., Flesh, F. M., Korte- Bouws, G. A. H., Sastre Torano, J., Hogewoning, A., Raasveld, S. J., Garssen, J., & Verster, J. C. (2016). Urine ethyl glucuronide (EtG) and ethyl sulphate (EtS) concentrations the day after heavy alcohol consumption. Alcoholism: Clinical and Experimental Research, 40(51), 100A-100A. Article 337. https://doi.org/10.1111/acer.13084
Dymek, K., Panarese, V., Herremans, E., Cantre, D., Schoo, R., Torano, J. S., Schlupmann, H., Wadso, L., Verboven, P., Nicolai, B. M., Dejmek, P., & Galindo, F. G. (2016). Investigation of the metabolic consequences of impregnating spinach leaves with trehalose and applying a pulsed electric field. Bioelectrochemistry, 112, 153-157. https://doi.org/10.1016/j.bioelechem.2016.02.006
van Haren, M. J., Sastre Torano, J., Sartini, D., Emanuelli, M., Parsons, R. B., & Martin, N. I. (2016). A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase. Biochemistry, 55(37), 5307-5315. https://doi.org/10.1021/acs.biochem.6b00733
Naksuriya, O., van Steenbergen, M. J., Sastre Torano, J., Okonogi, S., & Hennink, W. E. (2016). A Kinetic Degradation Study of Curcumin in Its Free Form and Loaded in Polymeric Micelles. The AAPS journal, 18(3), 777-787. https://doi.org/10.1208/s12248-015-9863-0
Prior, A., Sánchez-Hernández, L., Sastre-Toraño, J., Marina, M. L., de Jong, G. J., & Somsen, G. W. (2016). Enantioselective analysis of proteinogenic amino acids in cerebrospinal fluid by capillary electrophoresis–mass spectrometry. Electrophoresis, 37(17-18), 2410-2419. https://doi.org/10.1002/elps.201600015
Sevšek, A., Čelan, M., Erjavec, B., Quarles van Ufford, L., Sastre Toraño, J., Moret, E. E., Pieters, R. J., & Martin, N. I. (2016). Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase. Organic & Biomolecular Chemistry, 14(37), 8670-3. https://doi.org/10.1039/c6ob01735e

Other output

van de Loo, A. J. A. E., Vanneer, R. H. P., Wang, X., Nguyen, T. T., Flesh, F. M., Korte-Bouws, G. A. H., Torano, J. S., Hogewoning, A., Raasveld, S. J., Garssen, J., & Verster, J. C. (2016). URINE ETHYL GLUCURONIDE (ETG) AND ETHYL SULPHATE (ETS) CONCENTRATIONS THE DAY AFTER HEAVY ALCOHOL CONSUMPTION. Alcoholism: Clinical and Experimental Research, 40(S1), 100A-100A. Article 337.

2015

Scholarly publications

Jordan, N. Y., Mimpen, J. Y., van den Bogaard, W. J. M., Flesch, F. M., van de Meent, M. H. M., & Torano, J. S. (2015). Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping. Journal of chromatography. B, 995, 70-73. https://doi.org/10.1016/j.jchromb.2015.05.020
Shirangi, M., Sastre Toraño, J., Sellergren, B., Hennink, W. E., Somsen, G. W., & Van Nostrum, C. F. (2015). Methyleneation of peptides by N, N, N, N -tetramethylethylenediamine (TEMED) under conditions used for free radical polymerization: A mechanistic study. Bioconjugate Chemistry, 26(1), 90-100. https://doi.org/10.1021/bc500445d
https://dspace.library.uu.nl/bitstream/handle/1874/308745/bc500445d.pdf?sequence=1

2014

Scholarly publications

Medina-Casanellas, S., Tak, Y. H., Benavente, F., Sanz-Nebot, V., Sastre Toraño, J., Somsen, G. W., & de Jong, G. J. (2014). Evaluation of fritless solid-phase extraction coupled on-line with capillary electrophoresis-mass spectrometry for the analysis of opioid peptides in cerebrospinal fluid. Electrophoresis, 35(20), 2996-3002. https://doi.org/10.1002/elps.201400293

2013

Scholarly publications

Moreno-Gonzalez, D., Sastre Torano, J., Gamiz-Gracia, L., Garcia-Campana, A. M., de Jong, G. J., & Somsen, G. W. (2013). Micellar electrokinetic chromatography-electrospray ionization mass spectrometry employing a volatile surfactant for the analysis of amino acids in human urine. Electrophoresis, 34, 2615-2622.

2012

Scholarly publications

Sastre Torano, J., Delatte, T. L., Schlupmann, H., Smeekens, J. C. M., de Jong, G. J., & Somsen, G. W. (2012). Determination of trehalose-6-phosphate in Arabidopsis thaliana seedings by hydrophilic-interaction liquid chromatography-mass spectrometry. Analytical and Bioanalytical Chemistry, 403, 1353-1360.
Tak, Y. H., Sastre Torano, J., Somsen, G. W., & de Jong, G. J. (2012). Optimization of in-line fritless solid-phase extraction for capillary electrophoresis-mass spectrometry. Journal of Chromatography A, 1267, 138-143.

2011

Scholarly publications

Gomes Coimbra, M. J., Isacchi, B., van Bloois, L., Sastre Torano, J., Ket, A., Wu, X., Broere, F., Metselaar, J. M., Rijcken, C. J. F., Storm, G., Bilia, R., & Schiffelers, R. M. (2011). Improving solubitity and chemical stability of natural compounds for medicinal use by incorporation into liposomes. International Journal of Pharmaceutics, 416(2), 433-442. https://doi.org/10.1016/j.ijpharm.2011.01.056

2010

Scholarly publications

Vinkers, C. H., Korte-Bouws, G. A. H., Sastre Torano, J., Mirza, N. R., Nielsen, E. O., Ahring, P. K., de Jong, G. J., & Olivier, B. (2010). The rapid hydolysis of chlordiazepoxide to demoxepam may affect the outcome of chronic osmotic minipump studies. Psychopharmacology, 208, 555-562.
Ramautar, R., Sastre Torano, J., Somsen, G. W., & de Jong, G. J. (2010). Evaluation of CE methods for global metabolic profiling of urine. Electrophoresis, 31, 2319-2327.

2009

Scholarly publications

Silvertand, L. H. H., Torano, J. S., de Jong, G. J., & van Bennekom, W. P. (2009). Development and characterization of cIEF-MALDI-TOF MS for protein analysis. Electrophoresis, 30(10), 1828-1835. https://doi.org/10.1002/elps.200800740
Somsen, G. W., Tak, Y. H., Sastre Torano, J., Jongen, P., & de Jong, G. J. (2009). Determination of oversulfated chondroitin sulfate and dermatan sulfate impurities in heparin by capillary electrophoresis. Journal of Chromatography A, 1216(18), 4107-4112.

Professional publications

Tak, Y. H., Sastre Torano, J., de Jong, G. J., & Somsen, G. W. (2009). CE analysis of oversulfated chondroitin sulfate and dermatan sulfate in heparin samples. P/ACE Setter, 13.

2008

Scholarly publications

Silvertand, L. H. H., Torano, J. S., van Bennekom, W. P., & de Jong, G. J. (2008). Recent developments in capillary isoelectric focusing. Journal of Chromatography A, 1204(2), 157-170. https://doi.org/10.1016/j.chroma.2008.05.057
Silvertand, L. H. H., Torano, J. S., de Jong, G. J., & van Bennekom, W. P. (2008). Improved repeatability and matrix-assisted desorption/ionization - time of flight mass spectrometry compatibility in capillary isoelectric focusing. Electrophoresis, 29(10), 1985-1996. https://doi.org/10.1002/elps.200700434

2007

Scholarly publications

Catai, J. R., Torano, J. S., Jongen, P. M. J. M., de Jong, G. J., & Somsen, G. W. (2007). Analysis of recombinant human growth hormone by capillary electrophoresis with bilayer-coated capillaries using UV and MS detection. Journal of chromatography. B, 852(1-2), 160-166. https://doi.org/10.1016/j.jchromb.2007.01.007
Catai, J. R., Torano, J. S., de Jong, G. J., & Somsen, G. W. (2007). Capillary electrophoresis-mass spectrometry of proteins at medium pH using bilayer-coated capillaries. Analyst, 132(1), 75-81. https://doi.org/10.1039/b607178c

2006

Scholarly publications

Catai, J. R., Sastre Torano, J., de Jong, GJ., & Somsen, GW. (2006). Efficient and highly reproducible capillary electrophoresis-mass spectrometry of peptides using Polybrene-poly(vinyl sulfonate)-coated capillaries. Electrophoresis, 27(11), 2091-2099. https://doi.org/10.1002/elps.200500915

2004

Scholarly publications

van Kan, HJM., Spieksma, M., Groeneveld, GJ., Sastre Torano, J., van den Berg, LH., & Guchelaar, HJ. (2004). A validated HPLC assay to monitor riluzole plasma or serum concentrations in patients with amyotrophic lateral sclerosis. Biomedical Chromatography, 18(9), 723-726. https://doi.org/10.1002/bmc.384

Other output

van Kan, HJM., Groeneveld, GJ., Sastre Torano, J., Spieksma, M., van den Berg, LH., & Guchelaar, HJ. (2004). Correlation between riluzole clearance and CYP1A2 activity in patients with amyotrophic lateral sclerosis. British Journal of Clinical Pharmacology, 57(3), 367-368.

2003

Scholarly publications

Wu, YH., Feenstra, MGP., Zhou, JN., Liu, RY., Sastre Torano, J., Van Kan, HJM., Fischer, DF., Ravid, R., & Swaab, DF. (2003). Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: Alterations in preclinical and clinical stages. Journal of Clinical Endocrinology and Metabolism, 88(12), 5898-5906. https://doi.org/10.1210/jc.2003-030833
Sastre Torano, J., & van Kan, HJM. (2003). Simultaneous determination of the tobacco smoke uptake parameters nicotine, cotinine and thiocyanate in urine, saliva and hair, using gas chromatography-mass spectrometry for characterisation of smoking status of recently exposed subjects. Analyst, 128(7), 838-843. https://doi.org/10.1039/b304051h

2002

Scholarly publications

Kwadijk, S., & Sastre Torano, J. (2002). High-performance liquid chromatographic method with ultraviolet detection for the determination of dapsone and its hydroxylated metabolite in human plasma. Biomedical Chromatography, 16(3), 203-208. https://doi.org/10.1002/bmc.132

Other output

Merkus, P., Guchelaar, HJ., Van Rijn-Bikker, PC., Sastre Torano, J., Bosch, DA., & Merkus, FWHM. (2002). Nasal drug delivery to the cerebrospinal fluid: transport of a lipophilic compound. British Journal of Clinical Pharmacology, 54(5), 560-560.

2001

Scholarly publications

Sastre Torano, J. (2001). Inter- and intraindividual variability of riluzole serum concentrations in patients with ALS. Journal of the Neurological Sciences. https://doi.org/10.1016/s0022-510x(01)00613-x
Sastre Torano, J., & van Hattum, SHC. (2001). Quantitative analysis of active compounds in pharmaceutical preparations by use of attenuated total-reflection Fourier transform mid-infrared spectrophotometry and the internal standard method. Fresenius' journal of analytical chemistry, 371(4), 532-535.
Sastre Torano, J., Vermes, A., & Guchelaar, HJ. (2001). Simultaneous determination of flucytosine and fluorouracil in human plasma by high-performance liquid chromatography. Biomedical Chromatography, 15(2), 89-94.
Groeneveld, G. J., van Kan, H. J. M., Sastre Torano, J., Veldink, J. H., Guchelaar, H. J., Wokke, J. H. J., & van den Berg, L. H. (2001). Inter- and intra-individual variability of riluzole serum concentrations in patients with ALS. Journal of the Neurological Sciences, 191(1-2), 121-125.

2000

Scholarly publications

Sastre Torano, J., van Rijn-Bikker, P., Merkus, P., & Guchelaar, HJ. (2000). Quantitative determination of melatonin in human plasma and cerebrospinal fluid with high-performance liquid chromatography and fluorescence detection. Biomedical Chromatography, 14(5), 306-310.

1999

Scholarly publications

Sastre Toraño, J., & Guchelaar, H-J. (1999). Determination of erythromycin, roxithromycin, azithromycin and clarithromycin in serum by HPLC-RP with 9-fluorenylmethyloxy-carbonyl chloride derivatization ad fluorescence detection | Bepaling in serum met behulp van HPLC-RP met 9- fluorenylmethyloxycarbonylchloridederivatisering en fluorescentidetectie: Erytromycine, roxitromycine, azitromycine en claritromycine. Pharmaceutisch Weekblad.
Sastre Torano, J., Verbon, A., & Guchelaar, HJ. (1999). Quantitative determination of thalidomide in human serum with high-performance liquid chromatography using protein precipitation with trichloroacetic acid and ultraviolet detection. Journal of chromatography. B, Biomedical sciences and applications, 734(2), 203-210.

1998

Scholarly publications

Sastre Torano, J., & Guchelaar, HJ. (1998). Quantitative determination of the macrolide antibiotics erythromycin, roxithromycin, azithromycin and clarithromycin in human serum by high-performance liquid chromatography using pre-column derivatization with 9-fluorenylmethyloxycarbonyl chloride and fluorescence detection. Journal of chromatography. B, Biomedical sciences and applications, 720(1-2), 89-97.