The Nightingale Study is a large occupational prospective cohort study that started enrollment in the Netherlands in October 2011. On this website you will find more information on the purpose, design and recruitment, and organization of the Nightingale Study as well as publications and opportunities for collaboration.

• prof. dr. ir. R.C.H. (Roel) Vermeulen
• prof. dr. ir. J. (Hans) Kromhout

EXPANSE is a five-year European research project that focuses on the urban exposome and involves 20 academic and non-academic partners located in 14 European countries and the USA. The project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874627 and is coordinated by Utrecht University. We are part of the human exposome network, the world’s largest network of projects studying the impact of environmental exposure on human health. For more information see: www.expanseproject.eu

I am co-coordinator of EXPANSE, supervise PhD students and Postdocs focusing on studying the internal exposome en lead the work package "Build and Operate an Open Urban Exposome Toolbox". 

• dr. T.S. (Tabea) Sonnenschein
• dr. R.W.R. (Robert) van Vorstenbosch MSc

The Exposome Project for Health and Occupational Research (EPHOR) will lay the groundwork for evidence-based and cost-effective prevention for improving health at work, by developing a working life exposome toolbox. This toolbox can be used by scientists, occupational health practitioners, and policy makers. The consortium consists of 19 exposure, health, and data scientists and technology partners from 12 different countries. Together we will advance occupational health science in a unique way to reduce the burden of disease.

• prof. dr. ir. R.C.H. (Roel) Vermeulen
• drs. I.E. (Inka) Pieterson
• dr. L. (Lützen) Portengen
• dr. C.B. (Calvin) Ge
• dr. Susan Peters
• T.W.J. (Tara) van der Grinten MSc
• W. (Wenxin) Wan MSc

HBM4EU is a European project financed by the Horizon 2020 programme. People are exposed to a complex mixture of chemicals in their daily lives through the environment, consumer products, food and drinking water and at work. HBM4EU will use human biomonitoring to assess human exposure to chemicals in Europe, to better understand the associated health impacts and to improve chemical risk assessment. IRAS is involved in several work packages, primarily focused on human exposure to mixtures of chemicals, emerging substances, and integrated modeling of exposure-biomarker-health relationships. 

In the Klokwerk study the association between working at night on changes in lifestyle, disruptions in the circadian rhythm, and biological perturbations are studied. 

• drs. D. (Daniella) van de Langenberg
• prof. dr. ir. R.C.H. (Roel) Vermeulen

This project aims to develop a novel approach to the assessment of exposure to high priority environmental pollutants by characterizing the external and the internal components of the exposome, focusing on air and water contaminants during critical periods of life. To this end, the project will centre on 1) exposure assessment at the personal and population levels within existing European short- and long-term population studies, exploiting available tools and methods which we will develop for personal exposure monitoring (PEM)(e.g. portable sensors, smartphone-based technologies, high-resolution chemical analysis); and 2) multiple “omic” technologies for the analysis of biological samples (internal markers of external exposures). The search for the relationships between external exposures (as measured by PEM, which has not previously been used in large scale studies) and global profiles of molecular features (as measured by omics) in the same individuals constitutes a novel advance towards the development of "next generation exposure assessment" for environmental chemicals and their mixtures. The linkage with disease risks opens the way to what are defined here as ‘exposome-wide association studies’ (EWAS).

• prof. dr. ir. R.C.H. (Roel) Vermeulen
• dr. ir. G. (Gerard) Hoek
• E.J.H.M. (Erik) van Nunen MSc