Publications
2024
Scholarly publications
Kocabas, L. I., Ayyoubi, S., Tajqurishi, M., Quodbach, J., Vermonden, T., & Kok, R. J. (2024). 3D-printed prednisolone phosphate suppositories with tunable dose and rapid release for the treatment of inflammatory bowel disease. International Journal of Pharmaceutics, 649, Article 123639. https://doi.org/10.1016/j.ijpharm.2023.123639
2023
Scholarly publications
Tikhomirov, E., Åhlén, M., Di Gallo, N., Strømme, M., Kipping, T., Quodbach, J., & Lindh, J. (2023). Selective laser sintering additive manufacturing of dosage forms: Effect of powder formulation and process parameters on the physical properties of printed tablets. International Journal of Pharmaceutics, 635, 1-11. Article 122780. https://doi.org/10.1016/j.ijpharm.2023.122780
https://dspace.library.uu.nl/bitstream/handle/1874/435944/1-s2.0-S0378517323002004-main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/435944/1-s2.0-S0378517323002004-main.pdf?sequence=1
Ponsar, H., & Quodbach, J. (2023). Customizable 3D Printed Implants Containing Triamcinolone Acetonide: Development, Analysis, Modification, and Modeling of Drug Release. Pharmaceutics, 15(8), Article 2097. https://doi.org/10.3390/pharmaceutics15082097
Mazur, H., Erbrich, L., & Quodbach, J. (2023). Investigations into the use of machine learning to predict drug dosage form design to obtain desired release profiles for 3D printed oral medicines. Pharmaceutical Development and Technology, 28(2), 219-231. https://doi.org/10.1080/10837450.2023.2173778
https://dspace.library.uu.nl/bitstream/handle/1874/435586/Investigations_into_the_use_of_machine_learning_to_predict_drug_dosage_form_design_to_obtain_desired_release_profiles_for_3D_printed_oral_medicines.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/435586/Investigations_into_the_use_of_machine_learning_to_predict_drug_dosage_form_design_to_obtain_desired_release_profiles_for_3D_printed_oral_medicines.pdf?sequence=1
Hoffmann, L., Breitkreutz, J., & Quodbach, J. (2023). Investigation of the degradation and in-situ amorphization of the enantiomeric drug escitalopram oxalate during Fused Deposition Modeling (FDM) 3D printing. European Journal of Pharmaceutical Sciences, 185, Article 106423. https://doi.org/10.1016/j.ejps.2023.106423
https://dspace.library.uu.nl/bitstream/handle/1874/435583/1-s2.0-S0928098723000544-main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/435583/1-s2.0-S0928098723000544-main.pdf?sequence=1
Gottschalk, N., Bogdahn, M., & Quodbach, J. (2023). 3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing. International Journal of Pharmaceutics: X, 5, Article 100179. https://doi.org/10.1016/j.ijpx.2023.100179
https://dspace.library.uu.nl/bitstream/handle/1874/435579/1-s2.0-S2590156723000233-main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/435579/1-s2.0-S2590156723000233-main.pdf?sequence=1
Andreadis, I. I., Schulzen, A., Quodbach, J., & Bergström, C. A. S. (2023). Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations. European Journal of Pharmaceutical Sciences, 189, Article 106524. https://doi.org/10.1016/j.ejps.2023.106524
https://dspace.library.uu.nl/bitstream/handle/1874/435546/1-s2.0-S0928098723001549-main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/435546/1-s2.0-S0928098723001549-main.pdf?sequence=1
2022
Scholarly publications
Hoffmann, L., Breitkreutz, J., & Quodbach, J. (2022). Fused Deposition Modeling (FDM) 3D Printing of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate. Pharmaceutics, 14(11), 1-14. https://doi.org/10.3390/pharmaceutics14112411
de Backere, C., Quodbach, J., De Beer, T., Vervaet, C., & Vanhoorne, V. (2022). Impact of alternative lubricants on process and tablet quality for direct compression. International Journal of Pharmaceutics, 624, 1-13. Article 122012. https://doi.org/10.1016/j.ijpharm.2022.122012
https://dspace.library.uu.nl/bitstream/handle/1874/425538/1_s2.0_S0378517322005671_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/425538/1_s2.0_S0378517322005671_main.pdf?sequence=1
Holm, T. P., Kokott, M., Knopp, M. M., Boyd, B. J., Berthelsen, R., Quodbach, J., & Löbmann, K. (2022). Development of a multiparticulate drug delivery system for in situ amorphisation. European Journal of Pharmaceutics and Biopharmaceutics, 180, 170-180. https://doi.org/10.1016/j.ejpb.2022.09.021
Windolf, H., Chamberlain, R., Breitkreutz, J., & Quodbach, J. (2022). 3D Printed Mini-Floating-Polypill for Parkinson’s Disease: Combination of Levodopa, Benserazide, and Pramipexole in Various Dosing for Personalized Therapy. Pharmaceutics, 14(5), 1-22. Article 931. https://doi.org/10.3390/pharmaceutics14050931
Klinken, S., & Quodbach, J. (2022). Sums of amplitudes analysis – A new non-parametric classification method for time series deviation evaluation in pharmaceutical processes. Powder Technology, 412, 1-12. Article 118003. https://doi.org/10.1016/j.powtec.2022.118003
https://dspace.library.uu.nl/bitstream/handle/1874/425535/1_s2.0_S0032591022008841_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/425535/1_s2.0_S0032591022008841_main.pdf?sequence=1
Hoffmann, L., Breitkreutz, J., & Quodbach, J. (2022). Hot-Melt Extrusion of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate. Pharmaceutics, 14(10), 1-17. Article 2091. https://doi.org/10.3390/pharmaceutics14102091
Windolf, H., Chamberlain, R., Delmotte, A., & Quodbach, J. (2022). Blind-Watermarking—Proof-of-Concept of a Novel Approach to Ensure Batch Traceability for 3D Printed Tablets. Pharmaceutics, 14(2), 1-17. Article 432. https://doi.org/10.3390/pharmaceutics14020432
Windolf, H., Chamberlain, R., & Quodbach, J. (2022). Dose-independent drug release from 3D printed oral medicines for patient-specific dosing to improve therapy safety. International Journal of Pharmaceutics, 616, 1-15. Article 121555. https://doi.org/10.1016/j.ijpharm.2022.121555
Gottschalk, N., Quodbach, J., Elia, A. G., Hess, F., & Bogdahn, M. (2022). Determination of feed forces to improve process understanding of Fused Deposition Modeling 3D printing and to ensure mass conformity of printed solid oral dosage forms. International Journal of Pharmaceutics, 614, 1-12. Article 121416. https://doi.org/10.1016/j.ijpharm.2021.121416
Chamberlain, R., Windolf, H., Geissler, S., Quodbach, J., & Breitkreutz, J. (2022). Precise Dosing of Pramipexole for Low-Dosed Filament Production by Hot Melt Extrusion Applying Various Feeding Methods. Pharmaceutics, 14(1), 1-17. Article 216. https://doi.org/10.3390/pharmaceutics14010216
2021
Scholarly publications
Quodbach, J., Bogdahn, M., Breitkreutz, J., Chamberlain, R., Eggenreich, K., Elia, A. G., Gottschalk, N., Gunkel-Grabole, G., Hoffmann, L., Kapote, D., Kipping, T., Klinken, S., Loose, F., Marquetant, T., Windolf, H., Geißler, S., & Spitz, T. (2021). Quality of FDM 3D Printed Medicines for Pediatrics: Considerations for Formulation Development, Filament Extrusion, Printing Process and Printer Design. Therapeutic Innovation and Regulatory Science, 56, 910-928. https://doi.org/10.1007/s43441-021-00354-0
Windolf, H., Chamberlain, R., & Quodbach, J. (2021). Predicting drug release from 3D printed oral medicines based on the surface area to volume ratio of tablet geometry. Pharmaceutics, 13(9), Article 1453. https://doi.org/10.3390/pharmaceutics13091453
Rahman, J., & Quodbach, J. (2021). Versatility on demand – The case for semi-solid micro-extrusion in pharmaceutics. Advanced Drug Delivery Reviews, 172, 104-126. https://doi.org/10.1016/j.addr.2021.02.013
Berardi, A., Bisharat, L., Quodbach, J., Abdel Rahim, S., Perinelli, D. R., & Cespi, M. (2021). Advancing the understanding of the tablet disintegration phenomenon – An update on recent studies. International Journal of Pharmaceutics, 598, Article 120390. https://doi.org/10.1016/j.ijpharm.2021.120390
Gottschalk, N., Bogdahn, M., Harms, M., & Quodbach, J. (2021). Brittle polymers in Fused Deposition Modeling: An improved feeding approach to enable the printing of highly drug loaded filament. International Journal of Pharmaceutics, 597, Article 120216. https://doi.org/10.1016/j.ijpharm.2021.120216
2020
Scholarly publications
El Aita, I., Rahman, J., Breitkreutz, J., & Quodbach, J. (2020). 3D-Printing with precise layer-wise dose adjustments for paediatric use via pressure-assisted microsyringe printing. European Journal of Pharmaceutics and Biopharmaceutics, 157, 59-65. https://doi.org/10.1016/j.ejpb.2020.09.012
Ponsar, H., Wiedey, R., & Quodbach, J. (2020). Hot-melt extrusion process fluctuations and their impact on critical quality attributes of filaments and 3d-printed dosage forms. Pharmaceutics, 12(6), 1-15. Article 511. https://doi.org/10.3390/pharmaceutics12060511
Aita, I. E., Breitkreutz, J., & Quodbach, J. (2020). Investigation of semi-solid formulations for 3D printing of drugs after prolonged storage to mimic real-life applications. European Journal of Pharmaceutical Sciences, 146, Article 105266. https://doi.org/10.1016/j.ejps.2020.105266
Lenhart, V., Quodbach, J., & Kleinebudde, P. (2020). Fibrillated Cellulose via High Pressure Homogenization: Analysis and Application for Orodispersible Films. AAPS PharmSciTech, 21(1), Article 33. https://doi.org/10.1208/s12249-019-1593-7
Lenhart, V., Quodbach, J., & Kleinebudde, P. (2020). Mechanistic understanding regarding the functionality of microcrystalline cellulose and powdered cellulose as pelletization aids in wet-extrusion/spheronization. Cellulose, 27(4), 2189-2210. https://doi.org/10.1007/s10570-019-02895-y
2019
Scholarly publications
Gökpinar, S., Ernst, S. J., Hastürk, E., Möllers, M., El Aita, I., Wiedey, R., Tannert, N., Nießing, S., Abdpour, S., Schmitz, A., Quodbach, J., Füldner, G., Henninger, S. K., & Janiak, C. (2019). Air-Con Metal-Organic Frameworks in Binder Composites for Water Adsorption Heat Transformation Systems. Industrial and Engineering Chemistry Research, 58(47), 21493-21503. https://doi.org/10.1021/acs.iecr.9b04394
Reimers, T., Thies, J., Stöckel, P., Dietrich, S., Pein-Hackelbusch, M., & Quodbach, J. (2019). Implementation of real-time and in-line feedback control for a fluid bed granulation process. International Journal of Pharmaceutics, 567, Article 118452. https://doi.org/10.1016/j.ijpharm.2019.118452
Niese, S., Breitkreutz, J., & Quodbach, J. (2019). Development of a dosing device for individualized dosing of orodispersible warfarin films. International Journal of Pharmaceutics, 561, 314-323. https://doi.org/10.1016/j.ijpharm.2019.03.019
Hastürk, E., Schlüsener, C., Quodbach, J., Schmitz, A., & Janiak, C. (2019). Shaping of metal-organic frameworks into mechanically stable monoliths with poly(vinyl alcohol) by phase separation technique. Microporous and Mesoporous Materials, 280, 277-287. https://doi.org/10.1016/j.micromeso.2019.02.011
Toson, P., Lopes, D. G., Paus, R., Kumar, A., Geens, J., Stibale, S., Quodbach, J., Kleinebudde, P., Hsiao, W. K., & Khinast, J. (2019). Model-based approach to the design of pharmaceutical roller-compaction processes. International Journal of Pharmaceutics: X, 1, Article 100005. https://doi.org/10.1016/j.ijpx.2019.100005
Niese, S., & Quodbach, J. (2019). Formulation development of a continuously manufactured orodispersible film containing warfarin sodium for individualized dosing. European Journal of Pharmaceutics and Biopharmaceutics, 136, 93-101. https://doi.org/10.1016/j.ejpb.2019.01.011
Bisharat, L., AlKhatib, H. S., Muhaissen, S., Quodbach, J., Blaibleh, A., Cespi, M., & Berardi, A. (2019). The influence of ethanol on superdisintegrants and on tablets disintegration. European Journal of Pharmaceutical Sciences, 129, 140-147. https://doi.org/10.1016/j.ejps.2019.01.004
Reimers, T., Thies, J., Dietrich, S., Quodbach, J., & Pein-Hackelbusch, M. (2019). Evaluation of in-line particle measurement with an SFT-probe as monitoring tool for process automation using a new time-based buffer approach. European Journal of Pharmaceutical Sciences, 128, 162-170. https://doi.org/10.1016/j.ejps.2018.11.026
Infanger, S., Haemmerli, A., Iliev, S., Baier, A., Stoyanov, E., & Quodbach, J. (2019). Powder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid binder. International Journal of Pharmaceutics, 555, 198-206. https://doi.org/10.1016/j.ijpharm.2018.11.048
El Aita, I., Breitkreutz, J., & Quodbach, J. (2019). On-demand manufacturing of immediate release levetiracetam tablets using pressure-assisted microsyringe printing. European Journal of Pharmaceutics and Biopharmaceutics, 134, 29-36. https://doi.org/10.1016/j.ejpb.2018.11.008
2018
Scholarly publications
El Aita, I., Ponsar, H., & Quodbach, J. (2018). A critical review on 3d-printed dosage forms. Current Pharmaceutical Design, 24(42), 4957-4978. https://doi.org/10.2174/1381612825666181206124206
El Aita, I., Ponsar, H., & Quodbach, J. (2018). A critical review on 3d-printed dosage forms. Current Pharmaceutical Design, 24(42), 4957-4978. https://doi.org/10.2174/1381612825666181206124206
Niese, S., & Quodbach, J. (2018). Application of a chromatic confocal measurement system as new approach for in-line wet film thickness determination in continuous oral film manufacturing processes. International Journal of Pharmaceutics, 551(1-2), 203-211. https://doi.org/10.1016/j.ijpharm.2018.09.028
Ekmekciyan, N., Tuglu, T., El-Saleh, F., Muehlenfeld, C., Stoyanov, E., & Quodbach, J. (2018). Competing for water: A new approach to understand disintegrant performance. International Journal of Pharmaceutics, 548(1), 491-499. https://doi.org/10.1016/j.ijpharm.2018.07.025
Korte, C., & Quodbach, J. (2018). 3D-Printed Network Structures as Controlled-Release Drug Delivery Systems: Dose Adjustment, API Release Analysis and Prediction. AAPS PharmSciTech, 19(8), 3333-3342. https://doi.org/10.1208/s12249-018-1017-0
Korte, C., & Quodbach, J. (2018). Formulation development and process analysis of drug-loaded filaments manufactured via hot-melt extrusion for 3D-printing of medicines. Pharmaceutical Development and Technology, 23(10), 1117-1127. https://doi.org/10.1080/10837450.2018.1433208
2017
Scholarly publications
Sieber, D., Lazzari, A., Quodbach, J., & Pein, M. (2017). Applicability of two automated disintegration apparatuses for rapidly disintegrating (mini)tablets. Pharmaceutical Development and Technology, 22(2), 198-205. https://doi.org/10.1080/10837450.2016.1189935
2016
Scholarly publications
Quodbach, J., & Kleinebudde, P. (2016). A critical review on tablet disintegration. Pharmaceutical Development and Technology, 21(6), 763-774. https://doi.org/10.3109/10837450.2015.1045618
2015
Scholarly publications
Quodbach, J., & Kleinebudde, P. (2015). Performance of tablet disintegrants: Impact of storage conditions and relative tablet density. Pharmaceutical Development and Technology, 20(6), 762-768. https://doi.org/10.3109/10837450.2014.920357
2014
Scholarly publications
Quodbach, J., & Kleinebudde, P. (2014). Systematic classification of tablet disintegrants by water uptake and force development kinetics. Journal of Pharmacy and Pharmacology, 66(10), 1429-1438. https://doi.org/10.1111/jphp.12276
Quodbach, J., & Kleinebudde, P. (2014). A new apparatus for real-time assessment of the particle size distribution of disintegrating tablets. Journal of Pharmaceutical Sciences, 103(11), 3657-3665. https://doi.org/10.1002/jps.24168
Quodbach, J., Moussavi, A., Tammer, R., Frahm, J., & Kleinebudde, P. (2014). Tablet disintegration studied by high-resolution real-time magnetic resonance imaging. Journal of Pharmaceutical Sciences, 103(1), 249-255. https://doi.org/10.1002/jps.23789
Quodbach, J., Moussavi, A., Tammer, R., Frahm, J., & Kleinebudde, P. (2014). Assessment of disintegrant efficacy with fractal dimensions from real-time MRI. International Journal of Pharmaceutics, 475(1), 605-612. https://doi.org/10.1016/j.ijpharm.2014.09.021
2012
Scholarly publications
Quodbach, J., Mosig, J., & Kleinebudde, P. (2012). Compaction behavior of isomalt after roll compaction. Pharmaceutics, 4(4), 494-500. https://doi.org/10.3390/pharmaceutics4040494