dr. ir. J.A. (Jan) Mol
Associate Professor

Gegenereerd op 2017-11-20 07:09:06


Profile

Jan Mol is principal investigator in the field of endocrinology, oncology and functional genomics of companion animals. He is project leader of the program on Comparative and Translational Oncology which is part of the Tissue Repair program of the faculty of Veterinary Medicine.

He is responsible for the scientific and laboratory part of the oncology program. The projects are focussed around the role of cancer stem cells in mammary gland, adrenal gland, and in insulinomas. The laboratory has ample expertise in gene expression studies (microarray, qRT-PCR), cell culture (transfection, organoid culture), FACS analysis and protein chemistry (IHC, Wblot).

His special interest is the role of progesterone in the pathogenesis of mammary cancer and in mammary cancer stem cell differentiation. Hallmarks are the discovery of the local mammary expression of growth hormone (GH) and IGF-I, expression analysis of mammary genes using microarray analysis, the unique role of the canine progesterone receptor-B and the Wnt signalling in mammary carcinogenesis.

Strategic themes / Focus areas
Gegenereerd op 2017-11-20 07:09:06
Curriculum vitae

 

Training:

 

Agricultural University of Wageningen, The Netherlands

Agricultural engineer - 1981

Study:           Molecular Sciences

Orientation:   Biochemistry (Prof. Dr. C. Veeger)

                    Toxicology (Prof. Dr. J. Koeman)

                    Chemical Carcinogenesis (Prof. Dr. L. den Engelse)

                    Animal Physiology (Dr. J. Mattheij)

 

Erasmus University of Rotterdam, The Netherlands

Doctor medical sciences - 1985

Ph.D. thesis:    The deiodination of thyroid hormone in rat liver

Promotor:        Prof. Dr. G. Henneman

Co-promotor:   Dr. Ir. T.J. Visser

 

Functions:

1981-1984 PhD, Stichting voor ZWO, Department of Internal Medicine, Dijkzigt Ziekenhuis, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands


1984-1987 Assistent Professor. Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.


1987- Associate Professor. Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Gegenereerd op 2017-11-20 07:09:06

Selected publications:

  • Gracanin A, van Wolferen ME, Sartorius CA, Brenkman AB, Schoonen WG, Mol JA. Canid progesterone receptors lack activation function 3 domain-dependent activity. ENDOCRINOLOGY 153: 6104-6113, 2012.
  • Selvarajah GT, Verheije MH, Kik M, Slob A, Rottier PJ, Mol JA, Kirpensteijn J Expression of epidermal growth factor receptor in canine osteosarcoma: association with clinicopathological parameters and prognosis. VET J 193:412-419, 2012
  • de Jong MK, Schoemaker NJ, Mol JA.  Expression of sfrp1 and activation of the Wnt pathway in the adrenal glands of healthy ferrets and neutered ferrets with hyperadrenocorticism. VET J 2012
  • Buishand FO, van Erp MG, Groenveld HA, Mol JA, Kik M, Robben JH, Kooistra HS, Kirpensteijn J. Expression of insulin-like growth factor-1 by canine insulinomas and their metastases. VET J 191(3): 334-340, 2012
  • Galac S, Kool MM, Naan EC, Daminet S, Mol JA, Kooistra HS. Expression of the ACTH receptor, steroidogenic acute regulatory protein, and steroidogenic enzymes in canine cortisol-secreting adrenocortical tumors. DOMEST ANIM ENDOCRINOL 39(4):259-67, 2010
  • Galac S, Kars VJ, Klarenbeek S, Teerds KJ, Mol JA, Kooistra HS. Expression of receptors for luteinizing hormone, gastric-inhibitory polypeptide, and vasopressin in normal adrenal glands and cortisol-secreting adrenocortical tumors in dogs. DOMEST ANIM ENDOCRINOL 39(1):63-75, 2010
  • Selvarajah GT, Kirpensteijn J, van Wolferen ME, Rao NA, Fieten H, Mol JA. Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times. MOL CANCER 8:72, 2009.
  • Rao NA, van Wolferen ME, Gracanin A, Bhatti SF, Krol M, Holstege FC, Mol JA. Gene expression profiles of progestin-induced canine mammary hyperplasia and spontaneous mammary tumors. J PHYSIOL PHARMACOL 60 Suppl 1: 73-84, 2009.
  • Timmermans-Sprang EP, Rao NA, Mol JA: Transactivation of a growth hormone (GH) promoter-luciferase construct in canine mammary cells. DOMEST ANIM ENDOCRINOL 34: 403-410, 2008.
  • Rao NA, van Wolferen ME, van den Ham R, van Leenen D, Groot Koerkamp MJ, Holstege FC, Mol JA: cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype. ANIM GENET 39: 333-345, 2008
  • Lai CL, van den Ham R, van Leenders G, van der Lugt J, Mol JA, Teske E: Histopathological and immunohistochemical characterization of canine prostate cancer. Prostate 68: 477-488, 2008
  • Galac S, Kars VJ, Voorhout G, Mol JA, Kooistra HS: ACTH-independent hyperadrenocorticism due to food-dependent hypercortisolemia in a dog: a case report. VET J 177: 141-143, 2008
  • Robben JH, van den Brom WE, Mol JA, van Haeften TW, Rijnberk A: Effect of octreotide on plasma concentrations of glucose, insulin, glucagon, growth hormone, and cortisol in healthy dogs and dogs with insulinoma. RES VET SCI 80: 25-32, 2006
  • Hanson JM, Kooistra HS, Mol JA, Teske E, Meij BP: Plasma profiles of adrenocorticotropic hormone, cortisol, alpha-melanocyte-stimulating hormone, and growth hormone in dogs with pituitary-dependent hyperadrenocorticism before and after hypophysectomy. J ENDOCRINOL 190: 601-609, 2006
  • Bhatti SF, Duchateau L, Okkens AC, Van Ham LM, Mol JA, Kooistra HS: Treatment of growth hormone excess in dogs with the progesterone receptor antagonist aglepristone. THERIOGENOLOGY 66: 797-803, 2006
  • Marinelli L, Gabai G, Wolfswinkel J, Mol JA. Mammary steroid metabolizing enzymes in relation to progestin treatment and tumorigenesis in the dog. J STEROID BIOCHEM MOL BIOL 92: 167-173, 2004.
  • Rijnberk A, Kooistra HS, Mol JA. Endocrine diseases in dogs and cats: similarities and differences with endocrine diseases in humans. GROWTH HORM IGF RES. Suppl A:S158-64, 2003
  • Robben JH, Van Garderen E, Mol JA, Wolfswinkel J, Rijnberk A. Locally produced growth hormone in canine insulinomas. MOL CELL ENDOCRINOL. 197(1-2):187-95, 2002.
  • Kirpensteijn J, Timmermans-Sprang EP, van Garderen E, Rutteman GR, Lantinga-van Leeuwen IS, Mol JA. Growth hormone gene expression in canine normal growth plates and spontaneous osteosarcoma. MOL CELL ENDOCRINOL. 197(1-2):179-85, 2002.
  • Lantinga-van Leeuwen IS, Timmermans-Sprang EA, Mol JA. Cloning and characterization of the 5'-flanking region of the canine growth hormone gene. MOL CELL ENDOCRINOL. 197(1-2):133-41, 2002.
  • Schoemaker NJ, Teerds KJ, Mol JA, Lumeij JT, Thijssen JH, Rijnberk A. The role of luteinizing hormone in the pathogenesis of hyperadrenocorticism in neutered ferrets. MOL CELL ENDOCRINOL. 197(1-2):117-25, 2002.
  • Favier RP, Mol JA, Kooistra HS, Rijnberk A Large body size in the dog is associated with transient GH excess at a young age. J ENDOCRINOL 170:479-84, 2001.
  • Kooistra HS, den Hertog E, Okkens AC, Mol JA, Rijnberk A. Pulsatile secretion pattern of growth hormone during the luteal phase and mid-anoestrus beagle bitches. J REPROD FERTIL 119:217-222, 2000.
  • Lantinga-van Leeuwen IS, Van Garderen E, Rutteman GR, Mol JA. Cloning and cellular localization of the canine progesterone receptor. J STEROID BIOCHEM MOL BIOL 75:219-228, 2000.
  • Mahapokai W, Xue Y, Van Garderen E, Van Sluijs FJ, Mol JA, Schalken JA. Cell kinetics and differentiation after hormonal-induced prostatic hyperplasia in the dog. PROSTATE 44:40-48, 2000.
  • Lantinga-van Leeuwen IS, Mol JA, Kooistra HS, Rijnberk A, Breen M, Renier C,van Oost BA. Cloning of the canine gene encoding transcription factor Pit-1 and its exclusion as candidate gene in a canine model of pituitary dwarfism.  MAMM GENOME. 11:31-36, 2000.
  • Van Garderen E, van der Poel HJ, Swennenhuis JF, Wissink EH, Rutteman GR,Hellmen E, Mol JA, Schalken JA. Expression and molecular characterization of the growth hormone receptor in canine mammary tissue and mammary tumors.  ENDOCRINOLOGY 140:5907-14, 1999.
  • Lantinga-van Leeuwen IS, Oudshoorn M, Mol JA: Canine mammary growth hormone gene transcription initiates at the pituitary-specific start site in the absence of Pit-1.  MOL CELL ENDOCRINOL 150: 121-128, 1999.
  • Oosterlaken-Dijksterhuis MA, Kwant MM, Slob A, Hellmen E, Mol JA: IGF I and Retinoic Acid Regulate the Distribution Pattern of IGFBPs Synthesized by the Canine Mammary Tumor Cell Line CMT U335.  BREAST CANCER RES TREAT 54:11-23, 1999
  • Van de Wetering JK, Elfring RH, Oosterlaken-Dijksterhuis MA, Mol JA, Haagsman HP, Batenburg JJ: Perinatal Expression of IGFBPs in Rat Lung and Its Hormonal Regulation in Fetal Lung Explants.  AMER J PHYSIOL-LUNG CELL M PH 17:L1174-L1181, 1997
  • Van Garderen E, De Wit M, Voorhout WF, Rutteman GR, Mol JA, Nederbragt H, Misdorp W: Expression of Growth Hormone in Canine Mammary Tissue and Mammary Tumors Evidence for a Potential Autocrine/Paracrine Stimulatory Loop.  AMER J PATHOL 150:1037-1047, 1997
  • Mol JA, Van Garderen E, Rutteman GR, Rijnberk A: New Insights in the Molecular Mechanism of Progestin Induced Proliferation of Mammary Epithelium Induction of the Local Biosynthesis of Growth Hormone (GH) in the Mammary Gland of Dogs, Cats and Humans.  J STEROID BIOCHEM MOL BIOL 57:67-71, 1996
  • Mol JA, Van Garderen E, Selman PJ, Wolfswinkel J, Rijnberk A, Rutteman GR: Growth Hormone Messenger RNA in Mammary Gland Tumors of Dogs and Cats.  J CLIN INVEST 95:2028-2034, 1995
  • Mol JA, Henzen-Logmans SC, Hageman P, Misdorp W, Blankenstein MA, Rijnberk A: Expression of the Gene Encoding Growth Hormone in the Human Mammary Gland.  J CLIN ENDOCRINOL METAB 80:3094-3096, 1995
  • Selman PJ, Mol JA, Rutteman GR, Van Garderen E, Rijnberk AD: Progestin Induced Growth Hormone Excess in the Dog Originates in the Mammary Gland.  ENDOCRINOLOGY 134:287-292, 1994
  • Mol JA, Van Wolferen M, Kwant I, Meloen R: Predicted Primary and Antigenic Structure of Canine Corticotropin Releasing Hormone.  NEUROPEPTIDES 27:7-13, 1994
  • Rothuizen J, Reul JM, Van Sluijs FJ, Mol JA, Rijnberk A, De Kloet ER: Increased Neuroendocrine Reactivity and Decreased Brain Mineralocorticoid Receptor Binding Capacity in Aged Dogs.  ENDOCRINOLOGY 132:161-168, 1993
  • Van Wijk PA, Rijnberk A, Croughs RJ, Voorhout G, Sprang EP, Mol  JA. Corticotropin-releasing hormone and adrenocorticotropic hormone concentrations in cerebrospinal fluid of dogs with pituitary-dependent hyperadrenocorticism. ENDOCRINOLOGY 131: 2659-2662, 1992.
  • Rijnberk A, van Wees A, Mol JA. Assessment of two tests for the diagnosis of canine hyperadrenocorticism. VET REC 122: 178-180, 1988.
  • Wulffraat NM, Drexhage HA, Wiersinga WM, van der Gaag RD, Jeucken P, Mol JA. Immunoglobulins of patients with Cushing's syndrome due to pigmented adrenocortical micronodular dysplasia stimulate in vitro steroidogenesis. J CLIN ENDOCRINOL METAB 66: 301-307, 1988.
  • Mol JA, Visser TJ. Synthesis and some properties of sulfate esters and sulfamates of iodothyronines. ENDOCRINOLOGY 117: 1-7, 1985.
  • Mol JA, Visser TJ. Rapid and selective inner ring deiodination of thyroxine sulfate by rat liver deiodinase. ENDOCRINOLOGY 117: 8-12, 1985.
  • Otten MH, Mol JA, Visser TJ. Sulfation preceding deiodination of iodothyronines in rat hepatocytes. SCIENCE 221: 81- 83, 1983

 

Contributions to books

Mol JA, Lantinga-van LeeuwenIS, Van Garderen E, Rijnberk A. Progestin-induced Mammary Growth Hormone (GH) Production. In: “The Biology of the Mammary Gland”. (J.A. Mol, R. Clegg, eds). Plenum Press, London (2000) pp. 71-76.

 

Mol JA, Meij, BP. Pituitary Function. In: “Clinical Biochemistry of Domestic Animals, 6th edition”. (J.J. Kaneko, J.W. Harvey, M.L. Bruss eds.). Academic Press, Inc.; New York (2008) pp. 561-604.

 

Meij BP, Mol JA. Adrenocortical Function. In: “Clinical Biochemistry of Domestic Animals, 6th edition”. (J.J. Kaneko, J.W. Harvey, M.L. Bruss eds.). Academic Press, Inc.; New York (2008) pp. 605-622. 

Key publications

Gracanin, A., de Gier, J., Zegers, K., Bominaar, M., Rutteman, G.R., Schaefers-Okkens, A.C., Kooistra, H.S. & Mol, J.A. (2012). Progesterone receptor isoforms in the mammary gland of cats and dogs. Reproduction in Domestic Animals, 47 (6), (pp. 313-317) (5 p.).

All publications
  Articles - 2017
Timmermans-Sprang, Elpetra P M, Gracanin, Ana & Mol, Jan A (28.03.2017). Molecular Signaling of Progesterone, Growth Hormone, Wnt, and HER in Mammary Glands of Dogs, Rodents, and Humans - New Treatment Target Identification. Frontiers in Veterinary Science, 4, (pp. 53).
  Articles - 2016
Buishand, Floryne O, Arkesteijn, Ger J A, Feenstra, Laurien R, Oorsprong, Claire W D, Mestemaker, Margiet, Starke, Achim, Speel, Ernst-Jan M, Kirpensteijn, Jolle & Mol, Jan A (2016). Identification of CD90 as Putative Cancer Stem Cell Marker and Therapeutic Target in Insulinomas. Stem Cells and Development, 25 (11), (pp. 826-835).
Sanders, K., Mol, J. A., Kooistra, H. S., Slob, A. & Galac, S. (01.05.2016). New Insights in the Functional Zonation of the Canine Adrenal Cortex. Journal of Veterinary Internal Medicine, 30 (3), (pp. 741-750) (10 p.).
  Articles - 2015
Zandvliet, M, Teske, E, Schrickx, J A & Mol, J A (2015). A longitudinal study of ABC transporter expression in canine multicentric lymphoma. Veterinary Journal, 205 (2), (pp. 263-271) (9 p.). Copyright © 2014. Published by Elsevier Ltd..
Kool, Miriam M J, Galac, Sara, van der Helm, Noortje, Spandauw, Catharina G, Kooistra, Hans S & Mol, Jan A (2015). Expression of somatostatin, dopamine, progesterone and growth hormone receptor mRNA in canine cortisol-secreting adrenocortical tumours. Veterinary Journal (3 p.). Copyright © 2015 Elsevier Ltd. All rights reserved..
Mauchle, Ulrike, Selvarajah, Gayathri T, Mol, Jan A, Kirpensteijn, Jolle & Verheije, Monique H (11.08.2015). Identification of anti-proliferative kinase inhibitors as potential therapeutic agents to treat canine osteosarcoma. Veterinary Journal
Kool, M M J, Galac, S, van der Helm, N, Corradini, S, Kooistra, H S & Mol, J A (2015). Insulin-Like Growth Factor-Phosphatidylinositol 3 Kinase Signaling in Canine Cortisol-Secreting Adrenocortical Tumors. Journal of Veterinary Internal Medicine, 29 (1), (pp. 214-224) (11 p.). Copyright © 2015 by the American College of Veterinary Internal Medicine..
Grünberg, W, Mol, J A & Teske, E (2015). Red blood cell phosphate concentration and osmotic resistance during dietary phosphate depletion in dairy cows. Journal of Veterinary Internal Medicine, 29 (1), (pp. 395-399) (5 p.). Copyright © 2014 by the American College of Veterinary Internal Medicine..
  Articles - 2014
L'Eplattenier, Henry, Teske, Erik, Van Sluijs, Freek & Mol, Jan A (16.11.2014). CAG-repeats in the androgen receptor gene relate with plasma androgen levels in the Bouvier Des Flandres. In Vivo, 28 (6), (pp. 1051-5) (5 p.).
Kool, M M J, Galac, S, Kooistra, H S & Mol, J A (2014). Expression of angiogenesis-related genes in canine cortisol-secreting adrenocortical tumors. Domestic Animal Endocrinology, 47, (pp. 73-82) (10 p.). Copyright © 2014 Elsevier Inc. All rights reserved..
Kool, M. M J, Galac, S., Kooistra, H. S. & Mol, J. A. (2014). Expression of angiogenesis-related genes in canine cortisol-secreting adrenocortical tumors. Domestic Animal Endocrinology, 47 (1), (pp. 73-82) (10 p.).
Galac, S, Kool, M M J, van den Berg, M F, Mol, J A & Kooistra, H S (2014). Expression of steroidogenic factor 1 in canine cortisol-secreting adrenocortical tumors and normal adrenals. Domestic Animal Endocrinology, 49, (pp. 1-5) (5 p.).
de Jong, M K, ten Asbroek, E E M, Sleiderink, A J, Conley, A J, Mol, J A & Schoemaker, N J (2014). Gonadectomy-related adrenocortical tumors in ferrets demonstrate increased expression of androgen and estrogen synthesizing enzymes together with high inhibin expression. Domestic Animal Endocrinology, 48, (pp. 42–47) (6 p.). Copyright © 2014 Elsevier Inc. All rights reserved..
Gracanin, Ana, Timmermans-Sprang, Elpetra P M, van Wolferen, Monique E, Rao, Nagesha A S, Grizelj, Juraj, Vince, Silvijo, Hellmen, Eva & Mol, Jan A (2014). Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression. PLoS One, 9 (6).
Gracanin, Ana, Voorwald, Fabiana A, van Wolferen, Monique, Timmermans-Sprang, Elpetra & Mol, Jan A (2014). Marginal activity of progesterone receptor B (PR-B) in dogs but high incidence of mammary cancer. Journal of Steroid Biochemistry and Molecular Biology, 144 Pt B, (pp. 492-9) (8 p.).
Campos, M, Kool, M M J, Daminet, S, Ducatelle, R, Rutteman, G, Kooistra, H S, Galac, S & Mol, J A (19.09.2014). Upregulation of the PI3K/Akt pathway in the tumorigenesis of canine thyroid carcinoma. Journal of Veterinary Internal Medicine, 28 (6), (pp. 1814–1823) (10 p.).
  Articles - 2013
Kool, M.M., Galac, S., Spandauw, C.G., Kooistra, H.S. & Mol, J.A. (2013). Activating Mutations of GNAS in Canine Cortisol-Secreting Adrenocortical Tumors. Journal of Veterinary Internal Medicine, 27 (6), (pp. 1486-1492) (7 p.).
Kool, M.M.J., Galac, S., Kooistra, H.S. & Mol, J.A. (2013). Expression of angiogenesis-related genes in canine cortisol-secreting adrenocortical tumors. Domestic Animal Endocrinology, (pp. 10.1111/jvim.12194) (1 p.).
de Jong, M.K., Schoemaker, N.J. & Mol, J.A. (2013). Expression of sfrp1 and activation of the Wnt pathway in the adrenal glands of healthy ferrets and neutered ferrets with hyperadrenocorticism. Veterinary Journal, 196 (2013), (pp. 176-180) (5 p.).
Buishand, F.O., Kirpensteijn, J., Jaarsma, A.A., Speel, EJ, Kik, M.J.L. & Mol, J.A. (2013). Gene expression profiling of primary canine insulinomas and their metastases. Veterinary Journal, 18 (S1090-0233(13)00044-0).
Selvarajah, G.T., Bonestroo, F.A.S., Kirpensteijn, J., Kik, M.J.L., van der Zee, R., van Eden, W., Timmermans-Sprang, E.P.M., Slob, A. & Mol, J.A. (2013). Heat shock protein expression analysis in canine osteosarcoma reveals HSP60 as a potentially relevant therapeutic target. Cell Stress and Chaperones, 18 (5), (pp. 607-622) (16 p.).
Selvarajah, Gaya, Kirpensteijn, Jolle, Kik, Marja, Sprang, E.P.M. & Mol, Jan (18.09.2013). Heat shock protein expression analysis in canine osteosarcoma reveals hsp90 as a potentially relevant therapeutic target. Cell Stress and Chaperones, 18 (5), (pp. 607-22).
Rutteman, G.R., Erich, S.A., Mol, J.A., Spee, B., Grinwis, G.C.M., Fleckenstein, L., London, C.A. & Efferth, T. (2013). Safety and efficacy field study of artesunate for dogs with non-resectable tumours. Anticancer Research, 33 (5), (pp. 1819-1827) (9 p.).
  Articles - 2012
Gracanin, A., van Wolferen, M.E., Sartorius, C.A., Brenkman, A.B., Schoonen, W.G. & Mol, J.A. (2012). Canid progesterone receptors lack activation function 3 domain-dependent activity. Endocrinology, 153 (12), (pp. 6104-6113) (10 p.).
Selvarajah, G.T., Verheije, M.H., Kik, M.J.L., Slob, A., Rottier, P.J.M., Mol, J.A. & Kirpensteijn, J. (2012). Expression of epidermal growth factor receptor in canine osteosarcoma: Association with clinicopathological parameters and prognosis. Veterinary Journal, 193 (2), (pp. 412-419) (8 p.).
Buishand, F.O., van Erp, M.G., Mol, J.A., Groenveld, H.A., Kik, M.J.L., Robben, J.H., Kooistra, H.S. & Kirpensteijn, J. (2012). Expression of insulin-likegrowthfactor-1 by canineinsulinomas and their metastases. Veterinary Journal, 191 (3), (pp. 334-340) (7 p.).
Gracanin, A., de Gier, J., Zegers, K., Bominaar, M., Rutteman, G.R., Schaefers-Okkens, A.C., Kooistra, H.S. & Mol, J.A. (2012). Progesterone receptor isoforms in the mammary gland of cats and dogs. Reproduction in Domestic Animals, 47 (6), (pp. 313-317) (5 p.).
  Articles - 2011
Beijerink, N.J., Lee, W.M., Stokhof, A.A., Voorhout, G., Mol, J.A. & Kooistra, H.S. (2011). Evaluation of pulsatile plasma concentrations of growth hormone in healthy dogs and dogs with dilated cardiomyopathy. American Journal of Veterinary Research, 72 (1), (pp. 59-63) (5 p.).
  Articles - 2010
Galac, S., Buijtels, J.J.C.W.M., Mol, J.A. & Kooistra, H.S. (2010). Effects of trilostane treatment on the pituitary-adrenocortical and renin-aldosterone axis in dogs with pituitary-dependent hypercortisolism. Veterinary Journal, 183 (1), (pp. 75-80) (6 p.).
Galac, S., Kool, M., Naan, E.C., Daminet, S., Mol, J.A. & Kooistra, H.S. (2010). Expression of ACTH receptor, steroidogenic acute regulatory protein and steroidogenic enzymes in canine cortisol-secreting adrenocortical tumors. Domestic Animal Endocrinology, 39 (4), (pp. 259-267) (9 p.).
Hanson, J.M., Mol, J.A. & Meij, B.P. (2010). Expression of leukemia inhibitory factor and leukemia inhibitory factor receptor in the canine pituitary gland and corticotrope adenomas. Domestic Animal Endocrinology, 38 (4), (pp. 260-271) (12 p.).
Galac, S., Kars, V.J., Klarenbeek, S., Teerds, K.J., Mol, J.A. & Kooistra, H.S. (2010). Expression of receptors for gastric-inhibitory polypeptide, luteinizing hormone, and vasopressin in normal adrenals and cortisol-secreting adrenocortical tumors in dogs. Domestic Animal Endocrinology, 39 (1), (pp. 63-75) (13 p.).
  Articles - 2009
Diaz-Espineira, M.M., Mol, J.A., Rijnberk, A. & Kooistra, H.S. (2009). Adenohypophyseal function in dogs with primary hypothyroidism and non-thyroidal illness. Journal of Veterinary Internal Medicine, 23, (pp. 100-107) (8 p.).
Pawlowski, K.M., Krol, M., Majewska, A., Badowska-Kozakiewicz, A., Mol, J.A., Malicka, E. & Motyl, T. (2009). Comparison of cellular and tissue transcriptional profiles in canine mammary tumor. Journal of Physiology and Pharmacology, 60 (Suppl. 1), (pp. 85-94) (10 p.).
Rao, N.A., van Wolferen, M.E., Gracanin, A., Bhatti, S.F., Krol, M., Holstege, F.C.P. & Mol, J.A. (2009). Gene expression profiles of progestin-induced canine mammary hyperplasia and spontaneous mammary tumors. Journal of Physiology and Pharmacology, 60 (suppl. 1), (pp. 73-84) (12 p.).
Selvarajah, G.T., Kirpensteijn, J., van Wolferen, M.E., Rao, N.A., Fieten, H. & Mol, J.A. (2009). Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times. Molecular Cancer, 8, (pp. 72) (1 p.). doi: 10.1186/1476-4598-8-72.
Lai, Chen-Li, van den Ham, R., Mol, J.A. & Teske, E. (2009). Immunostaining of the androgen receptor and sequence analysis of its DNA-binding domain in canine prostate cancer. Veterinary Journal, 181, (pp. 256-260) (5 p.).
Krol, M., Skierski, J., Rao, N.A., Hellmen, E., Mol, J.A. & Motyl, T. (2009). Transcriptomic profile of two canine mammary cancer cell lines with different proliferative and anti-apoptotic potential. Journal of Physiology and Pharmacology, 60 (Suppl. 1), (pp. 95-106) (12 p.).
  Articles - 2008
Galac, S., Kars, V.J., Voorhout, G., Mol, J.A. & Kooistra, H.S. (2008). ACTH-independent hyperadrenocorticism due to meal induced hypercortisolaemia in a dog. Veterinary Journal, 177, (pp. 141-143) (3 p.).
Lai, Chen-Li, van den Ham, H.J., Verseijden, F., Jagtenberg, A., Mol, J.A. & Teske, E. (2008). Androgen receptor CAG repeat polymorphisms in canine prostate cancer. Journal of Veterinary Internal Medicine, 22 (6), (pp. 1380-1384) (5 p.).
Rao, N.A., van Wolferen, M.E., van den Ham, R., van Leenen, D., Groot Koerkamp, M.J.A., Holstege, F.C.P. & Mol, J.A. (2008). cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype. Animal Genetics, 39 (4), (pp. 333-345) (13 p.).
Hanson, J.M., Mol, J.A., Leegwater, P.A.J., Bilodeau, S., Drouin, J. & Meij, B.P. (2008). Expression and mutation analysis of Tpit in the canine pituitary gland and corticotroph adenomas. Domestic Animal Endocrinology, 34, (pp. 454-460) (7 p.).
Diaz Espineira, M.M., Mol, J.A., van den Ingh, T.S.G.A.M., van der Vlugt-Meijer, R.H., Rijnberk, A. & Kooistra, H.S. (2008). Functional and morphological changes in the adenohypophysis of dogs with induced primary hypothyroidism; loss of TSH hypersecretion, hypersomatotropism, hypoprolactinemia, and pituitary enlargement with transdifferentiation. Domestic Animal Endocrinology, 35, (pp. 98-111) (13 p.).
Lai, Chen-Li, van den Ham, R., van Leenders, G., van der Lugt, J.J., Mol, J.A. & Teske, E. (2008). Histopathological and immunohistochemical characterization of canine prostate cancer. Prostate, 68, (pp. 477-488) (12 p.).
Diaz Espineira, M.M., Galac, S., Mol, J.A., Rijnberk, A. & Kooistra, H.S. (2008). Thyrotropin releasing hormone-induced growth hormone secretion in dogs with primary hypothyroidism. Domestic Animal Endocrinology, 34, (pp. 176-181) (6 p.).
Timmermans-Sprang, E.P.M., Rao, N.A. & Mol, J.A. (2008). Transactivation of a growth hormone (GH) promoter-luciferase construct in canine mammary cells. Domestic Animal Endocrinology, 34 (4), (pp. 403-410) (8 p.).
Sprang, E.P.M., Rao, Nagesha A S & Mol, Jan (2008). Transactivation of a growth hormone (GH) promoter-luciferase construct in canine mammary cells. Domestic Animal Endocrinology, 34 (4), (pp. 403-10).
Schoemaker, N.J., van Deijk, R., Muijlaert, B., Kik, M.J.L., Kuijten, A., de Jong, F.H., Trigg, T.E., Kruitwagen, C.L.J.J. & Mol, J.A. (2008). Use of a gonadotropin releasing hormone agonist implant as an alternative for surgical castration in male ferrets (Mustela putorius furo). Theriogenology, 70, (pp. 161-167) (7 p.).
  Articles - 2007
Beijerink, N.J., Bhatti, S.F., Schaefers-Okkens, A.C., Dieleman, S.J., Mol, J.A., Duchateau, L., van Ham, L.M. & Kooistra, H.S. (2007). Adenohypophyseal function in bitches treated with medroxyprogesterone acetate. Domestic Animal Endocrinology, 32, (pp. 63-78) (16 p.).
Cerundolo, R., Lloyd, D.H., Vaessen, M.M.A.R., Mol, J.A., Kooistra, H.S. & Rijnberk, A. (2007). Alopecia in pomeranians and miniature poodles in association with high urinary corticoid:creatinine ratios and resistance to glucocorticoid feedback. Veterinary Record, 160 (12), (pp. 393-397) (5 p.).
Diaz Espineira, M.M., Mol, J.A., Peeters, M.E., Pollak, Y.W., Iversen, L., van Dijk, J.E., Rijnberk, A. & Kooistra, H.S. (2007). Assessment of thyroid function in dogs with low plasma thyroxine concentration. Journal of Veterinary Internal Medicine, 21, (pp. 25-32) (8 p.).
Klarenbeek, M., Schaefers-Okkens, A.C., Kooistra, H.S., Mol, J.A., Bevers, M.M. & Taverne, M.A.M. (2007). Plasma oxytocin concentrations during late pregnancy and parturition in the dog. Theriogenology, 68 (8), (pp. 1169-1176) (7 p.).
Bhatti, S.F., Rao, N.S.R., Schaefers-Okkens, A.C., Mol, J.A., Duchateau, L., Ducatelle, R., van den Ingh, T.S.G.A.M., Tshamala, M., van Ham, L.M.L., Coryn, M., Rijnberk, A. & Kooistra, H.S. (2007). Role progestin-induced mammary-derived growth hormone in the pathogenesis of cystic endometrial hyperplasia in the bitch. Domestic Animal Endocrinology, 33, (pp. 294-312) (19 p.).
  Articles - 2006
Robben, J.H., van den Brom, W.E., Mol, J.A., van Haeften, T.W. & Rijnberk, A. (2006). Effect of octreotide on plasma concentrations of glucose, insulin, glucagon, growth hormone, and cortisol in healthy dogs and dogs with insulinoma. Research in Veterinary Science, 80 (1), (pp. 25-32) (8 p.).
Bhatti, S.F., Hofland, L.J., van Koetsveld, P.M., van Ham, L.M., Duchateau, L., Mol, J.A., van der Lely, A.J. & Kooistra, H.S. (2006). Effects of food intake and food withholding on plasma ghrelin concentrations in healthy dogs. American Journal of Veterinary Research, 67 (9), (pp. 1557-1563) (7 p.).
Bhatti, S.F., Duchateau, L., van Ham, L.M.L., de Vlieger, S.P., Mol, J.A., Rijnberk, A. & Kooistra, H.S. (2006). Effects of growth hormone secretagogues on the release of adenohypophyseal hormones in young and old healthy dogs. Veterinary Journal, 72 (3), (pp. 515-525) (11 p.).
Theyse, L.F.H., Oosterlaken-Dijksterhuis, M.A., van Doorn, J., Terlou, M., Mol, J.A., Voorhout, G. & Hazewinkel, H.A.W. (2006). Expression of osteotropic growth factors and growth hormone receptor in a canine distraction osteogenesis model. Journal of Bone and Mineral Research, 24 (4), (pp. 266-273) (8 p.).
Bhatti, S.F., van Ham, L.M., Mol, J.A. & Kooistra, H.S. (2006). Ghrelin, an endogenous growth hormone secretagogue with diverse endocrine and nonendocrine effects. American Journal of Veterinary Research, 67 (1), (pp. 180-188) (9 p.).
Bhatti, S.F., de Vliegher, S.P., Mol, J.A., van Ham, L.M. & Kooistra, H.S. (2006). Ghrelin-stimulation test in the diagnosis of canine pituitary dwarfism. Research in Veterinary Science, 81, (pp. 24-30) (7 p.).
Lee, M.H., Kooistra, H.S., Mol, J.A., Dieleman, S.J. & Schaefers-Okkens, A.C. (2006). Ovariectomy during the luteal phase influences secretion of prolactin, growth hormone, and insulin-like growth factor-I in the bitch. Theriogenology, 66, (pp. 484-490) (7 p.).
Hanson-Nilsson, J.M., Kooistra, H.S., Mol, J.A., Teske, E. & Meij, B.P. (2006). Plasma profiles of adrenocorticotropic hormone, cortisol, alpha-melanocyte-stimulating hormone, and growth hormone in dogs with pituitary-dependent hyperadrenocorticism before and after hypophysectomy. Journal of Endocrinology, 190 (3), (pp. 601-609) (9 p.).
Theyse, L.F.H., Mol, J.A., Voorhout, G., Terlou, M. & Hazewinkel, H.A.W. (2006). The efficacy of the bone markers osteocalcin and the carboxyterminal cross-linked telopeptide of type-I collagen in evaluating osteogenesis in a canine crural lengthening model. Veterinary Journal, 171, (pp. 525-531) (7 p.).
Hanson-Nilsson, J.M., Mol, J.A., Leegwater, P.A.J., Kooistra, H.S. & Meij, B.P. (2006). The leukemia inhibitory factor receptor gene is not involved in the etiology of pituitary dwarfism in German shepherd dogs. Research in Veterinary Science, 81 (3), (pp. 316-320) (5 p.).
Bhatti, S.F., Duchateau, L., Schaefers-Okkens, A.C., van Ham, L.M., Mol, J.A. & Kooistra, H.S. (2006). Treatment of growth hormone excess in dogs with the progesterone receptor antagonist aglepristone. Theriogenology, 66, (pp. 797-803) (7 p.).
  Articles - 2005
Galac, S., Kooistra, H.S., Voorhout, G., van den Ingh, T.S.G.A.M., Mol, J.A., van den Berg, L. & Meij, B.P. (2005). Hyperadrenocorticism in a dog due to ectopic secretion of adrenocorticotropic hormone. Domestic Animal Endocrinology, 28, (pp. 338-348) (11 p.).
  Articles - 2004
Coert, A., Verheijen, F.M., Horspool, L.J. & Mol, J.A. (2004). Aspects of pharmacodynamics and biotransformation of the glucocorticoid resocortol butyrate. Journal of Veterinary Pharmacology and Therapeutics, 27, (pp. 309-315) (7 p.).
Schoemaker, N.J., Mol, J.A., Lumeij, J.T., Thijssen, J.H.H. & Rijnberk, A. (2004). Effects of anaesthesia and manual restraint on the plasma concentrations of pituitary and adrenocortical hormones in ferrets. Veterinary Record, 152 (19), (pp. 591-595) (5 p.).
Duijsings, D.M.J.M., Houweling, M., Vaandrager, A.B., Mol, J.A. & Teerds, K.J. (2004). Hexadecylphosphocholine causes rapid cell death in canine mammary tumour cells. European Journal of Pharmacology, 502, (pp. 185-193) (9 p.).
Marinelli, L, Gabai, G, Wolfswinkel, J. & Mol, J.A. (2004). Mammary steroid metabolizing enzymes in relation to hyperplasia and tumorgenesis in the dog. Journal of Steroid Biochemistry and Molecular Biology, 92 (3), (pp. 167-173) (7 p.).
Javadi, S., Slingerland, L.I., van de Beek, M.G., Boer, P., Boer, W.H., Mol, J.A., Rijnberk, A. & Kooistra, H.S. (2004). Plasma renin activity and plasma concentrations of aldosterone, cortisol, adrenocorticotropic hormone, and alpha-melanocyte-stimulating hormone in healthy cats. Journal of Veterinary Internal Medicine, 18, (pp. 625-631) (7 p.).
Geerars-van Vonderen, I.K., Wolfswinkel, J., van den Ingh, T.S.G.A.M., Mol, J.A., Rijnberk, A. & Kooistra, H.S. (2004). Urinary aquaporin-2 excretion in dogs: a marker for collecting duct responsiveness to vasopressin. Domestic Animal Endocrinology, 27, (pp. 141-153) (13 p.).
Vaessen, M.M.A.R., Kooistra, H.S., Mol, J.A. & Rijnberk, A. (2004). Urinary corticoid:creatinine ratios in healthy pet dogs after oral low-dose dexamethasone suppression tests. Veterinary Record, 155, (pp. 18-21) (4 p.).
Schoemaker, N.J., Wolfswinkel, J., Mol, J.A., Voorhout, G., Lumeij, J.T., Rijnberk, A. & Kik, M.J.L. (2004). Urinary glucocorticoid excretion in the diagnosis of hyperadrenocorticism in ferrets. Domestic Animal Endocrinology, 27, (pp. 13-24) (12 p.).
  Articles - 2003
Tryfonidou, M.A., Oosterlaken-Dijksterhuis, M.A., Mol, J.A., van den Ingh, T.S.G.A.M., van den Brom, W.E. & Hazewinkel, H.A.W. (2003). 24-Hydroxylase: potential key regulator in hypervitaminosis D3 in growing dogs. American Journal of Physiology - Endocrinology and Metabolism, 284, (pp. 505-513) (9 p.).
Peters, M.A.J., Mol, J.A., van Wolferen, M.E., Oosterlaken-Dijksterhuis, M.A., Teerds, K.J. & van Sluijs, F.J. (2003). Expression of the insulin-like growth factor (IGF) system and steroidogeneic enzymes in canine testis tumors. Biology of Reproduction, 1:22, (pp. 1-8) (8 p.).
Javadi, S., Kooistra, H.S., Mol, J.A., Boer, P., Boer, W.H. & Rijnberk, A. (2003). Plasma aldosterone concentrations and plasma renin activity in healthy dogs and dogs with hyperadrenocorticism. Veterinary Record, 153, (pp. 521-525) (5 p.).
Rijnberk, A., Kooistra, H.S., Bhatti, S.F., Lee, W.M., Mol, J.A. & Meij, B.P. (2003). Pulsatile secretion pattern of growth hormone in dogs with pituitary-dependent hyperadrenocorticism. Domestic Animal Endocrinology, 44, (pp. 59-68) (10 p.).
  Articles - 2002
Lantinga-van Leeuwen, I.S., Timmermans-Sprang, E.P.M. & Mol, J.A. (2002). Cloning and characterization of the 5' flanking region of the canine growth hormone gene. Molecular and Cellular Endocrinology, 197, (pp. 133-141) (9 p.).
Lantinga-van Leeuwen, Irma, Sprang, E.P.M. & Mol, Jan (29.11.2002). Cloning and characterization of the 5'-flanking region of the canine growth hormone gene. Molecular and Cellular Endocrinology, 197 (1-2), (pp. 133-41).
Peeters, Marijke, Sprang, E.P.M. & Mol, Jan (2002). Feline thyroid adenomas are in part associated with mutations in the G (s alpha)gene and not with polymorphisms found in the thyrotropin receptor. Thyroid, 12 (7), (pp. 571-5).
Peeters, M.E., Timmermans-Sprang, E.P.M. & Mol, J.A. (2002). Feline thyroid adenomas are in part associated with mutations in the Gsalpha gene and not with polymorphisms found in the thyrotropin receptor. Thyroid, 12, (pp. 571-575) (5 p.).
Kirpensteijn, J., Timmermans-Sprang, E.P.M., van Garderen, E., Rutteman, G.R., Lantinga-van Leeuwen, I.S. & Mol, J.A. (2002). Growth hormone gene expression in canine normal growth plates and spontaneous osteosarcoma. Molecular and Cellular Endocrinology, 197, (pp. 179-185) (7 p.).
Kirpensteijn, Jolle, Sprang, E.P.M., Lantinga-van Leeuwen, I.S. & Mol, Jan (2002). Growth hormone gene expression in canine normal growth plates and spontaneous osteosarcoma. Molecular and Cellular Endocrinology, (pp. 179-85).
Robben, J.H., Mol, J.A., van Garderen, E., Wolfswinkel, J. & Rijnberk, A. (2002). Growth hormone mRNA and growth hormone protein in canine insulinomas. Molecular and Cellular Endocrinology, 197, (pp. 187-197) (9 p.).
Robben, J.H., van Garderen, E., Mol, J.A., Wolfswinkel, J. & Rijnberk, A. (2002). Locally produced growth hormone in canine insulinomas. Molecular and Cellular Endocrinology, 197, (pp. 187-195) (9 p.).
Tryfonidou, M.A., Stevenhagen, J.J., van den Bemd, G.J.C.M., Oosterlaken-Dijksterhuis, M.A., DeLuca, H.F., Mol, J.A., van den Brom, W.E., van Leeuwen, J.P.T.M. & Hazewinkel, H.A.W. (2002). Moderate cholecalciferol supplementation depresses intestinal calcium absorption in growing dogs. Journal of Nutrition, 132, (pp. 2644-2650) (7 p.).
Bosje, J.T., Rijnberk, A., Mol, J.A., Voorhout, G. & Kooistra, H.S. (2002). Plasma concentrations of ACTH precursors correlate with pituitary size and resistance to dexamethasone in dogs with pituitary-dependent hyperadrenocorticism. Domestic Animal Endocrinology, 22, (pp. 201-210) (10 p.).
Schoemaker, N.J., Mol, J.A., Lumeij, J.T. & Rijnberk, A. (2002). Plasma concentrations of adrenocorticotrophic hormone and alpha-melanocyte-stimulating hormone in ferrets (Mustela putorius furo) with hyperadrenocorticism. American Journal of Veterinary Research, 63, (pp. 1395-1399) (5 p.).
Schoemaker, N.J., Teerds, K.J., Mol, J.A., Lumeij, J.T., Thijssen, J.H.H. & Rijnberk, A. (2002). The role of luteinizing hormone in the pathogenesis of hyperadrenocorticism in neutered ferrets. Molecular and Cellular Endocrinology, 197, (pp. 117-125) (9 p.).
Tryfonidou, M.A., Oosterlaken-Dijksterhuis, M.A., Mol, J.A. & Hazewinkel, H.A.W. (2002). Verhoogde productie en verhoogde metabole klaring van 1,25(OH)2D3 bij langdurige vitamine-D3-suppletie. Nederlands Tijdschrift voor Osteoporose en Andere Botziekten, 6, (pp. 95-96) (2 p.).
  Articles - 2001
Rijnberk, A., Kooistra, H.S., Geerars-van Vonderen, I.K., Mol, J.A., Voorhout, G., van Sluijs, F.J., IJzer, J., van den Ingh, T.S.G.A.M., Boer, P. & Boer, W.H. (2001). Aldosteronoma in a dog with polyuria as the leading symptom. Domestic Animal Endocrinology, 20, (pp. 227-240) (14 p.).
Zijlstra, C, De Haan, N A, Lantinga-Van Leeuwen, I S, Mol, J A & Bosma, A A (2001). Assignment of progesterone receptor (PGR) to canine chromosome band 21q1.2 by in situ hybridization. Cytogenetics and Cell Genetics, 95 (3-4), (pp. 236-7) (2 p.).
Hazewinkel, H.A.W., Tryfonidou, M.A., Mol, J.A., How, K.L., Schoenmakers, I. & Nap, R.C. (2001). De invloed van UV-licht en calcium in de voeding op de plasmaconcentratie van vitamine D3-metabolieten bij de hond. Nederlands Tijdschrift voor Osteoporose en Andere Botziekten, (pp. 70-70) (1 p.).
Favier, R.P., Mol, J.A., Kooistra, H.S. & Rijnberk, A. (2001). Large body size in the dog is associated with transient GH excess at a young age. Journal of Endocrinology, 170, (pp. 479-484) (6 p.).
van Loo, P.L.P., Mol, J.A., Koolhaas, J.M., van Zutphen, L.F.M. & Baumans, V. (2001). Modulation of aggression in male mice: influence of group size and cage size. Physiology and Behavior, 72, (pp. 675-683) (9 p.).
Lee, W.M., Diaz-Espineira, M.M., Mol, J.A., Rijnberk, A. & Kooistra, H.S. (2001). Primary hypothyroidism in dogs is associated with elevated GH release. Journal of Endocrinology, 168, (pp. 59-66) (8 p.).
  Articles - 2000
Beerda, B., Schilder, M.B.H., van Hooff, J.A.R.A.M., de Vries, H. & Mol, J.A. (2000). Behavioral and hormonal indicators of enduring environmental stress in dogs. Animal Welfare, 9, (pp. 49-62) (14 p.).
Mol, J.A. & Clegg, R.A. (2000). Biology of the mammary gland. Advances in Experimental Medicine and Biology, 480, (pp. 1-311) (311 p.).
Suriyasathaporn-Mahapokai, W., Xue, Y., van Garderen, E., van Sluijs, F.J. & Mol, J.A. (2000). Cell kinetics and differentiation after hormonal-induced prostatic hyperplasia in the dog. Prostate, 44, (pp. 40-48) (9 p.).
Lantinga-van Leeuwen, I.S., Mol, J.A., Kooistra, H.S., Rijnberk, A., Breen, M, Renier, C. & van Oost, B.A. (2000). Cloning of canine gene encoding transcription factor pit-1 and its exclusion as canditate gene in a canine model of pituitary dwarfism. Mammalian Genome, 11, (pp. 31-36) (6 p.).
Lantinga-van Leeuwen, I.S., Kooistra, H.S., Mol, J.A., Renier, C., Breen, M & van Oost, B.A. (2000). Cloning, characterization, and physical mapping of the canine Prop-1 gene (PROP1); exclusion as a candidate for combined pituitary hormone deficiency in German shepherd dogs. Cytogenetics and Cell Genetics, 88, (pp. 140-144) (5 p.).
Kooistra, H.S., Voorhout, G., Mol, J.A. & Rijnberk, A. (2000). Combined pituitary hormone deficiency in German shepherd dogs with dwarfism. Domestic Animal Endocrinology, 19, (pp. 177-190) (14 p.).
Lantinga-van Leeuwen, I.S., Teske, E., van Garderen, E. & Mol, J.A. (2000). Growth hormone gene expression in normal lymph nodes and lymphomas of the dog. Anticancer Research, 20, (pp. 2371-2376) (6 p.).
Mol, J.A., Lantinga-van Leeuwen, I.S., van Garderen, E. & Rijnberk, A. (2000). Progestin-induced mammary growth hormone (GH) production. Advances in Experimental Medicine and Biology, 480, (pp. 71-76) (6 p.).
Kooistra, H.S., den Hertog, E.J., Okkens, A.C., Mol, J.A. & Rijnberk, A. (2000). Pulsatile secretion pattern of growth hormone during the luteal phase and mid-anoestrus in beagle bitches. Journal of Reproduction and Fertility, 119, (pp. 217-222) (6 p.).
Kooistra, H.S., Diaz-Espineira, M.M., Mol, J.A., van den Brom, W.E. & Rijnberk, A. (2000). Secretion pattern of thyroid-stimulating hormone in dogs during euthyroidism and hypothyroidism. Domestic Animal Endocrinology, 18, (pp. 19-29) (11 p.).
  Articles - 1999
Schoenmakers, I., Nap, R.C., Mol, J.A. & Hazewinkel, H.A.W. (1999). Calcium metabolism: an overview of its hormonal regulation and interrelation with skeletal integrity. Veterinary Quarterly, 21 (4), (pp. 147-153) (7 p.).
Beerda, B., Schilder, M.B.H., van Hooff, J.A.R.A.M., de Vries, H.W. & Mol, J.A. (1999). Chronic stress in dogs subjected to social and spatial restriction I. Behavioral Responses. Physiology and Behavior, 66 (2), (pp. 233-242) (10 p.).
Beerda, B., Schilder, M.B.H., Bernadina, W., van Hooff, J.A.R.A.M., de Vries, H.W. & Mol, J.A. (1999). Chronic stress in dogs subjected to social and spatial restriction II. Hormonal and immunological responses. Physiology and Behavior, 66 (2), (pp. 243-254) (12 p.).
  Articles - 1997
van Wijk, P.A., Rijnberk, A., Croughs, R.J.M., Meij, B.P., van Leeuwen, I.S., Sprang, E.P.M. & Mol, J.A. (1997). Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-depen dent hyperadrenocorticism. Journal of Endocrinological Investigation, 20, (pp. 1-7) (7 p.).
Schilder, M.B.H., Beerda, B., Janssen, N.S.C.R.M. & Mol, J.A. (1997). The use of Saliva cortisol, urinary cortisol, and catecholamine measurements for a noninvasive assessment of stress responses in dogs. Hormones and Behavior, 30, (pp. 272-279) (8 p.).
  Articles - 1995
Mol, J.A., Henzen-Lomans, S.C., Hageman, Ph., Misdorp, W., Blankenstein, M.A. & Rijnberk, A. (1995). Expression of the gene encoding growth hormone in the human mammary gland. Journal of Clinical Endocrinology and Metabolism, 44, (pp. 577-582) (6 p.).
  Book parts / chapters - 2008
Meij, B.P. & Mol, J.A. (2008). Adrenocortical Function. In JJ Kaneko, JW Harvey & ML Bruss (Eds.), Clinical Biochemistry of Domestic Animals (16 p.). USA: Academic Press.
Mol, J.A. & Meij, B.P. (2008). Pituitary function. In JJ Kaneko, JW Harvey & ML Bruss (Eds.), Clinical Biochemistry of Domestic Animals (pp. 561-604) (44 p.). USA: Academic Press.
  Articles in volumes / proceedings - 2010
Meij, B.P., Hanson-Nilsson, J.M. & Mol, J.A. (22.09.2010). Predictive value of postoperative plasma ACTH, α-MSH, and cortisol concentrations for recurrence after hypophysectomy in dogs with Cushing's disease. Proceedings European Neuroendocrine Association (ENEA) (pp. 76-76) (1 p.). Liège, Belgium, European Neuroendocrine Association (ENEA).
  Articles in volumes / proceedings - 2001
Mol, J.A. (29.08.2001). Introduction to RT-PCR and RIA/IRMA. International Symposium "Comparative Clinical and Molecular Endocrinology" - Utrecht The Netherlands. (pp. 39-41) (3 p.).
Favier, R.P., Mol, J.A., Kooistra, H.S. & Rijnberk, A. (05.09.2001). Plasma concentrations of growth hormone and insulin-like growth factors-I and -II during the prepubertal phase of the life of small and giant dog breeds. Proceedings of the 11th ESVIM Annual Congress, Dublin Ireland. (pp. 186-187) (2 p.).
Kooistra, H.S., Schaefers-Okkens, A.C., Dieleman, S.J., Mol, J.A. & Rijnberk, A. (05.09.2001). Pulsatile secretion patterns of adenohypophyseal hormones in relation to ovarian activity in the dog. Proceedings of the 11th ESVIM Annual Congress. (pp. 87-88) (2 p.).
van der Veek, Y, Dorrestein, G.M., Mol, J.A. & McLean, P. (23.05.2001). The effect of administration of potassium iodide on goitre and serum T4 levels in lesser spotted dogfish (Scylliorhinus caniculus). Proceedings of the 40th International Symposion on Diseases of Zooanimals and Wildlife. (pp. 35-40) (6 p.).
  Articles in volumes / proceedings - 2000
Mol, J.A. (14.09.2000). Hormone and insuline-like growth factors: modulators of proliferation and immune function. Proceedings of the Xth ESVIM Annual Congress (pp. 108-109) (2 p.). Neuchatel, Switzerland, Xth ESVIM Annual Congress.
  Lectures - 2014
J.A. Mol (06.10.2014) 9th International Conference of Anticancer Research
  Lectures - 2012
J.A. Mol (01.10.2012) Comparative breast cancer research, lessons from companion animals
J.A. Mol (01.07.2012) Molecular genetics and biology of progesterone signaling in mammary neoplasia
  Lectures - 2006
J.A. Mol (15.09.2006) Gene expression profiling of canine mammary tumor cell lines reveal three major pathways involved in tumor progression.
  Lectures - 0
J.A. Mol () Gene profiling of canine mammary carcinomas reveal major derailed signal transduction pathways
  Editorial activity - 2014
J.A. Mol (01.01.2014) Domestic Animal Endocrinology
  Editorial activity - 0
J.A. Mol () Jaarboek voor middeleeuwse geschiedenis
  Contribution to the work of national or international committees and working groups - 0
J.A. Mol () Guest editor
J.A. Mol () Secretaris wetenschappelijke adviescommissie van het Nederlands Kankerfonds voor Dieren
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Gegenereerd op 2017-11-20 07:09:06

Already during the study Molecular Sciences/Biochemistry at the Agricultural University of Wageningen an interest was developed in the molecular regulation of tissue differentiation and oncogenesis (animal physiology in Wageningen, and chemical carcinogenesis at the Netherlands Cancer Institute, Amsterdam).

The molecular endocrinology was further studied during a PhD period in which the mechanism of deiodination of thyroid hormone was studied in rat liver at the Erasmus University, Rotterdam, The Netherlands.

After my PhD study a new research laboratory was founded at the department of Clinical Sciences of Companion Animals for the benefit of a research program on molecular endocrinology in companion animals. During this period 19 PhD studies were guided as co-promoter around ACTH-producing pituitary tumors, adrenal gland tumors, and mammary, prostate and bone carcinomas, and insulin-producing pancreas carcinomas.

During recent years the interest is further focused on mechanisms of recruitment of tissue-specific stem cells resulting in proliferation and differentiation of tissues and the role of cancer stem cells in tumor formation and metastasis.

With respect to endocrine regulation a special interest exists in the role of progesterone or synthetic progestins and the progesterone receptor isoforms PR-A and PR-B in tumorigenesis in companion animals. Apart from endocrine regulation, studies are directed on the production of growth factors at the tissue level, which may result in paracrine or even autocrine growth stimulation. The focus is on the tissue-specific production of growth hormone (GH), the insulin-like growth factors (IGFs) and their binding proteins in mammary gland, insulinomas and adrenal tumors in relation to proliferation and apoptosis.

For these research lines modern technologies have been implemented for cell biology, protein chemistry and functional genomics.

Completed projects

Project:
Novel medical approach to canine hyperadrenocorticism with melanocortin 2 receptor (MC2R) antagonist and steroidogenic factor 1 (SF-1) inverse agonists 01.01.2015 to 31.12.2016
General project description

In this study, in vitro models of canine Cushing`s syndrome will be used to study new treatment options. In adrenocortical tumor tissue the investigators will assess the effectiveness of compounds, called SF-1 inverse agonists, on hormone production and tumor growth, which are the main characteristics of an adrenocortical tumor. Testing with these compounds holds promises for a new medical approach of even inoperable adrenocortical tumors. In normal adrenal glands, surrogating the pituitary-dependent hypercortisolism, the suppression of steroid production is sufficient. The investigators expect that compounds, called MC2 receptor antagonists, will be superior to the current treatment due to their selectivity.


Identifying novel medical options will improve current treatment of Cushing`s syndrome in dogs. 

 
Role Researcher Funding
External funding: Morris Animal Foundation
Project members UU
External project members:
  • Enzo Lalli
  • MD
Project:
Pathogenesis and treatment of canine cortisol-secreting adrenocortical tumors. 01.11.2009 to 01.11.2013
General project description

The comparative and translational oncology program is part of the focus areas Tissue Repair and Advances in Veterinary Medicine of the Faculty of Veterinary Sciences. 


In collaboration within the Utrecht University focus area "Growth and Differentiation" studies are oriented at the role of cancer stem cells in mammary, adrenal and insulin-producing carcinomas. 



  • Mammary carcinoma

  • Adrenocortical carcinoma

  • Insulinoma


In the program Advances in Veterinary Medicine translational research is oriented at



  • Soft tissue sarcoma

  • Lymphoma

  • Prostate carcinoma

  • Molecular imaging 

 
Role Project Leader
Individual project description

Comparative breast cancer research.


 


Under construction

Funding
External funding: Morris Animal Foundation- Pfizer Animal Health scholarship for advanced study
Project members UU

PhD studies guided:

P.J. Selman (1995)  Effects of progestin administration in the dog.

P.A. Maaskant-van Wijk (1996) In vivo and in vitro characteristics of corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism.

I. Westerhof (1997) Pituitary-adrenocortical function and glucocorticoid admini-stration in pigeons (Columba livia domestica).

B. Beerda (1997) Stress and Well-being in Dogs.

I.S. Lantinga-van Leeuwen (2000)  Regulation of growth hormone gene expression in the canine mammary gland.

E. van Garderen (2000) Investigations on the growth hormone / growth hormone receptor axis in the canine mammary gland.

W. Mahapokai (2000) Hormonally induced benign prostatic hyperplasia in the dog.

H.S. Kooistra (2000) Adenohypophyseal function in healthy dogs and in dogs with pituitary disease.

N. Schoemaker (2003) Hyperadrenocorticism in Ferrets

I. van Vonderen (2004) Studies on the role of vasopressin in canine polyuria.

J.H. Robben (2004) Insulinoma in dogs.

W.M. Lee (2004) Growth hormone secretion in healthy and diseased dogs

Sofie Bhatti (2006) Pituitary and mammary growth hormone in dogs

Jeanette Hanson (2007) Pathobiology and oncogenesis of pituitary corticotroph adenomas in dogs

Nagesha Rao (2008) Characterization of Canine Mammary Carcinoma using Dog-specific cDNA arrays

Montse Diaz (2008) Pituitary Function and Morphology in Dogs with Primary Hypothyroidism.

Henri L’Éplattenier (2009) Studies on the pathogenesis and management of prostate carcinoma in dogs

Sara Galac (2010) Recent developments in canine Cushing`s syndrome.

Gaya Selvarajah (2011) Prognostic markers and signaling pathways for canine and human osteosarcoma

Gegenereerd op 2017-11-20 07:09:06

Teaching in the bachelor programs:

From cell to tissue

From genome to population

Bachelor thesis

 

Teaching in the master programs:

Clinical pathology

Research training

 

PhD program:

Clinical and translational oncology

Gegenereerd op 2017-11-20 07:09:06
Full name
dr. ir. J.A. Mol Contact details
Jeannette Donker-Voetgebouw

Yalelaan 104-106
Room JDV 2.005
3584 CM  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 1709
Onbekend Gebouw

Onbekend 9999
Room JDV 2.005
9999 AA  ONBEKEND
The Netherlands


Phone number (direct) +31 30 253 1709
Availability
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Post address:

Dr. Ir. Jan A. Mol

JDV Building 2.005

Yalelaan 104

3584 CM Utrecht

The Netherlands

Gegenereerd op 2017-11-20 07:09:06
Last updated 27.01.2015