Publications
2023
Scholarly publications
Seesing, M. F. J., Janssen, H. J. B., Geraedts, T. C. M., Weijs, T. J., van Ark, I., Leusink-Muis, T., Folkerts, G., Garssen, J., Ruurda, J. P., Nieuwenhuijzen, G. A. P., van Hillegersberg, R., & Luyer, M. D. P. (2023). Exploring the Modulatory Effect of High-Fat Nutrition on Lipopolysaccharide-Induced Acute Lung Injury in Vagotomized Rats and the Role of the Vagus Nerve. Nutrients, 15(10), [2327]. https://doi.org/10.3390/nu15102327
2022
Scholarly publications
Pelgrim, C. E., van Ark, I., van Berkum, R. E., Schuitemaker-Borneman, A. M., Flier, I., Leusink-Muis, T., Janbazacyabar, H., Diks, M. A. P., Gosker, H. R., Kelders, M. C. J. M., Langen, R. C. J., Schols, A. M. W. J., Hageman, R. J. J., Braber, S., Garssen, J., Folkerts, G., van Helvoort, A., & Kraneveld, A. D. (2022). Effects of a nutritional intervention on impaired behavior and cognitive function in an emphysematous murine model of COPD with endotoxin-induced lung inflammation. Frontiers in Nutrition, 9, [1010989]. https://doi.org/10.3389/fnut.2022.1010989
Wang, L., van Iersel, L. E. J., Pelgrim, C. E., Lu, J., van Ark, I., Leusink-Muis, T., Gosker, H. R., Langen, R. C. J., Schols, A. M. W. J., Argilés, J. M., van Helvoort, A., Kraneveld, A. D., Garssen, J., Henricks, P. A. J., Folkerts, G., & Braber, S. (2022). Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue: In Vivo and In Vitro Studies. Cells, 11(18), 1-20. [2893]. https://doi.org/10.3390/cells11182893
Wang, L., Pelgrim, C. E., Peralta Marzal, L. N., Korver, S., van Ark, I., Leusink-Muis, T., van Helvoort, A., Keshavarian, A., Kraneveld, A. D., Garssen, J., Henricks, P. A. J., Folkerts, G., & Braber, S. (2022). Changes in intestinal homeostasis and immunity in a cigarette smoke- and LPS-induced murine model for COPD: the lung-gut axis. American journal of physiology. Lung cellular and molecular physiology, 323(3), L266-L280. https://doi.org/10.1152/ajplung.00486.2021
Pelgrim, C. E., Wang, L., Peralta Marzal, L. N., Korver, S., van Ark, I., Leusink-Muis, T., Braber, S., Folkerts, G., Garssen, J., van Helvoort, A., & Kraneveld, A. D. (2022). Increased exploration and hyperlocomotion in a cigarette smoke and LPS induced murine model of COPD: linking pulmonary and systemic inflammation with the brain. American journal of physiology. Lung cellular and molecular physiology, 323(3), L251-L265. https://doi.org/10.1152/ajplung.00485.2021
Pelgrim, C. E., van Ark, I., Leusink-Muis, T., Brans, M. A. D., Braber, S., Garssen, J., van Helvoort, A., Kraneveld, A. D., & Folkerts, G. (2022). Intratracheal administration of solutions in mice; development and validation of an optimized method with improved efficacy, reproducibility and accuracy. Journal of Pharmacological and Toxicological Methods, 114, 1-7. [107156]. https://doi.org/10.1016/j.vascn.2022.107156
2021
Scholarly publications
Janbazacyabar, H., van Bergenhenegouwen, J., Garssen, J., Leusink-Muis, T., Ark, I. V., van Daal, M. T., Folkerts, G., & Braber, S. (2021). Prenatal and Postnatal Cigarette Smoke Exposure Is Associated With Increased Risk of Exacerbated Allergic Airway Immune Responses: A Preclinical Mouse Model. Frontiers in Immunology, 12, 1-14. [797376]. https://doi.org/10.3389/fimmu.2021.797376
Toutounchi, N. S., Braber, S., Hogenkamp, A., Varasteh, S., Cai, Y., Wehkamp, T., Tims, S., Leusink-Muis, T., van Ark, I., Wiertsema, S., Stahl, B., Kraneveld, A. D., Garssen, J., Folkerts, G., & Van’T Land, B. (2021). Human milk oligosaccharide 3′-gl improves influenza-specific vaccination responsiveness and immunity after deoxynivalenol exposure in preclinical models. Nutrients, 13(9), [3190]. https://doi.org/10.3390/nu13093190
Janbazacyabar, H., van Daal, M., Leusink-Muis, T., van Ark, I., Garssen, J., Folkerts, G., van Bergenhenegouwen, J., & Braber, S. (2021). The Effects of Maternal Smoking on Pregnancy and Offspring: Possible Role for EGF? Frontiers in Cell and Developmental Biology, 9, 1-15. [680902]. https://doi.org/10.3389/fcell.2021.680902
Wang, L., Pelgrim, C. E., Swart, D. H., Krenning, G., van der Graaf, A. C., Kraneveld, A. D., Leusink-Muis, T., van Ark, I., Garssen, J., Folkerts, G., & Braber, S. (2021). SUL-151 Decreases Airway Neutrophilia as a Prophylactic and Therapeutic Treatment in Mice after Cigarette Smoke Exposure. International Journal of Molecular Sciences, 22(9), 1-17. [4991]. https://doi.org/10.3390/ijms22094991
Ayechu-Muruzabal, V., Xiao, L., Wehkamp, T., van Ark, I., Hoogendoorn, E. J., Leusink-Muis, T., Folkerts, G., Garssen, J., Willemsen, L. E. M., & Van’T Land, B. (2021). A fermented milk matrix containing postbiotics supports th1-and th17-type immunity in vitro and modulates the influenza-specific vaccination response in vivo in association with altered serum galectin ratios. Vaccines, 9(3), 1-17. [254]. https://doi.org/10.3390/vaccines9030254
2020
Scholarly publications
Ghiamati Yazdi, F., Zakeri, A., Ark, I. V., Leusink-Muis, T., Braber, S., Soleimanian-Zad, S., & Folkerts, G. (2020). Crude Turmeric Extract Improves the Suppressive Effects of Lactobacillus rhamnosus GG on Allergic Inflammation in a Murine Model of House Dust Mite-Induced Asthma. Frontiers in Immunology, 11, [1092]. https://doi.org/10.3389/fimmu.2020.01092
2019
Scholarly publications
Xiao, L., Engen, P. A., Leusink-Muis, T., Van Ark, I., Stahl, B., Overbeek, S. A., Garssen, J., Naqib, A., Green, S. J., Keshavarzian, A., Folkerts, G., & Van’t Land, B. (2019). The combination of 2-fucosyllactose with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides that enhance influenza vaccine responses is associated with mucosal immune regulation in mice. Journal of Nutrition, 149(5), 856-869. https://doi.org/10.1093/jn/nxz006
Kumawat, K., Geerdink, R. J., Hennus, M. P., Roda, M. A., Van Ark, I., Leusink-Muis, T., Folkerts, G., Van Oort-Jansen, A., Mazharian, A., Watson, S. P., Coenjaerts, F. E., Bont, L., & Meyaard, L. (2019). LAIR-1 limits neutrophilic airway inflammation. Frontiers in Immunology, 10(APR), [842]. https://doi.org/10.3389/fimmu.2019.00842
2018
Scholarly publications
Xiao, L., Leusink-Muis, T., Kettelarij, N., van Ark, I., Blijenberg, B., Hesen, N. A., Stahl, B., Overbeek, S. A., Garssen, J., Folkerts, G., & Van't Land, B. (2018). Human Milk Oligosaccharide 2'-Fucosyllactose Improves Innate and Adaptive Immunity in an Influenza-Specific Murine Vaccination Model. Frontiers in Immunology, 9, [452]. https://doi.org/10.3389/fimmu.2018.00452
2014
Scholarly publications
Bezemer, G., Van Ark, I., Leusink Muis, T., Kraneveld, A., Garssen, J., & Folkerts, G. (2014). Acetate is more effective than a glucocorticoid steroid at preventing and reducing neutrophilic airway inflammation in a cigarette smoke induced mouse model for copd. Basic & Clinical Pharmacology & Toxicology, 115, 285.
2013
Scholarly publications
van Noort, J. M., Bsibsi, M., Nacken, P. J., Gerritsen, W. H., Amor, S., Holtman, I. R., Boddeke, E., van Ark, I., Leusink-Muis, A., Folkerts, G., Hennink, W. E., & Amidi, M. (2013). Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles. Biomaterials, 34(3), 831-40.
2011
Scholarly publications
Kloek, J., Mortaz, E., Van Ark, I., Bloksma, N., Garssen, J., Nijkamp, F. P., & Folkerts, G. (2011). A whey-based glutathione-enhancing diet decreases allergen-induced airway contraction in a guinea-pig model of asthma. British Journal of Nutrition, 105(10), 1465-1470. https://doi.org/10.1017/S0007114510005337
Kloek, J., Mortaz, E., van Ark, I., Lilly, C. M., Nijkamp, F. P., & Folkerts, G. (2011). Glutathione prevents the early asthmatic reaction and airway hyperresponsivness in Guinea pigs. Journal of Physiology and Pharmacology, 61, 67-72.
Other output
Bezemer, G., Fillipov, D., Mortaz, E., Van Ark, I., Garssen, J., Kraneveld, A., Ossendorp, F., & Folkerts, G. (2011). Consequences of chronic pulmonary TLR9 activation in the lung and beyond.
2010
Scholarly publications
Kloek, J., Mortaz, E., van Ark, I., Lilly, C. M., Nijkamp, F. P., & Folkerts, G. (2010). Glutathione prevents the early asthmatic reaction and airway hyperresponsiveness in guinea pigs. Journal of Physiology and Pharmacology, 61(1), 67-72.
Other output
Bezemer, G. F. G., Mortaz, E., Den Brok, M., Van Ark, I., Kraneveld, A. D., Adema, G. J., Nijkamp, F., & Folkerts, G. (2010). Lps induced TNF-α production by bronchoaveolar lavage-and lung cells is increased in TLR 9 deficient mice.
2009
Scholarly publications
Verheijden, K., Van Houwelingen, A. H., Van Ark, I., Nijkamp, F. P., & Folkerts, G. (2009). Cigarette smoke-induced lung emphysema: C57BL/6 versus BALB/c. Naunyn-Schmiedeberg's Archives of Pharmacology, 379(2), 213. https://doi.org/10.1007/s00210-008-0340-5
2006
Scholarly publications
ten Broeke, R., de Crom, R., van Haperen, R., Verweij, V. G. M., Leusink-Muis, A., van Ark, I., de Clerck, F., Nijkamp, F. P., & Folkerts, G. (2006). Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice. Respiratory Research, 7.
2004
Scholarly publications
ten Broeke, R., Leusink-Muis, A., Hilberdink, R., van Ark, I., van den Worm, E., Villain, M., de Clerck, F., Blalock, J. E., Nijkamp, F. P., & Folkerts, G. (2004). Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Laboratory Investigation, 84, 29-40.
https://dspace.library.uu.nl/bitstream/handle/1874/14957/folkerts_04_specific_modulation.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/14957/folkerts_04_specific_modulation.pdf?sequence=1
2003
Scholarly publications
Kloek, J., van Ark, I., de Clerck, F., Bloksma, M. A., Nijkamp, F. P., & Folkerts, G. (2003). Modulation of airway hyperresponsiveness by thiols in a murine in vivo model of allergic asthma. Inflammation Research, 52, 126-131.
2002
Scholarly publications
Kloek, J., van Ark, I., Bloksma, N., De Clerck, F., Nijkamp, F. P., & Folkerts, G. (2002). Glutathione and other low-molecular-weight thiols relax guinea pig trachea ex vivo: interactions with nitric oxide? American journal of physiology. Lung cellular and molecular physiology, 283(2), L403-408. https://doi.org/10.1152/ajplung.00376.2001
2001
Scholarly publications
Muijsers, R. B. R., Ten Hacken, N. H. T., Van Ark, I., Folkerts, G., Nijkamp, F. P., & Postma, D. S. (2001). L-arginine is not the limiting factor for nitric oxide synthesis by human alveolar macrophages in vitro. European Respiratory Journal, 18(4), 667-671. https://doi.org/10.1183/09031936.01.00101301
Muijsers, R. B. R., van Ark, I., Folkerts, G., Koster, A. S., van Oosterhout, A. J. M., Postma, D. S., & Nijkamp, F. P. (2001). Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice. British Journal of Pharmacology, 134, 434-440.
2000
Other output
Muijsers, R. B. R., van Ark, I., Folkerts, G., van Oosterhout, A. J. M., Koster, A. S., Postma, D. S., & Nijkamp, F. P. (2000). Inhibitors of both NADPH-oxidase and nitric oxide synthase prevent airway hyperresponsiveness but not allergic inflammation in a murine model of asthma. 54-54. Abstract from Unknown event, Asilomar, USA.
1999
Scholarly publications
Hofstra, C. L., van Ark, I., Kool, M., Nijkamp, F. P., & van Oosterhout, A. J. M. (1999). Antigen-stimulated lung CD 4+ produce IL-5, while lymph node CD4+ cells produce Th2 cytokines concomitant with airway eosinophilia and hyperresponsiveness. Inflammation Research, 48, 602-612.
van Heuven-Nolsen, D., de Kimpe, J. J., Leusink-Muis, A., van Ark, I., Savelkoul, T. J. F., Beems, R. B., van Oosterhout, A. J. M., & Nijkamp, F. P. (1999). Opposite role of interferon-gamma and interleukin-4 on the regulation of blood pressure in mice. Biochemical and Biophysical Research Communications, 254, 816-820.
Other output
Hofstra, C. L., van Ark, I., Hofman, G. A., Kool, M., Nijkamp, F. P., & van Oosterhout, A. J. M. (1999). Prevention of Th2-like responses by co-administration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia and serum IgE levels. 130-130. Abstract from Unknown event, Asilomar, USA.
Muijsers, R. B. R., van Ark, I., Folkerts, G., Postma, D. S., & Nijkamp, F. P. (1999). Inhibition of peroxynitrite formation prevents allergen-induced hyperresponsiveness in a murine model of allergic asthma. 41-41. Abstract from Unknown event, Asilomar, USA.
1998
Scholarly publications
Hofstra, C. L., van Ark, I., Kool, M., Nijkamp, F. P., & van Oosterhout, A. J. M. (1998). Differential effects of endogenous and exogenous IFN-* on IgE, cellular infiltration and airway responsiveness in a murine model of allergic asthma. American Journal of Respiratory Cell and Molecular Biology, 19, 826-835.
Hofstra, C. L., van Ark, I., Hofman, G. A., Kool, M., Nijkamp, F. P., & van Oosterhout, A. J. M. (1998). Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia and serum IgE levels. Journal of Immunology, 161, 5054-5060.
Hessel, E. M., Cruikshank, W. W., van Ark, I., de Bie, J. J., Lobato-van Esch, E. C. A. M., Hofman, G. A., Nijkamp, F. P., Center, D. M., & van Oosterhout, A. J. M. (1998). Involvement of IL16 in the induction of airway hyperresponsiveness and upregulation of IgE in a murine model of allergic asthma. Journal of Immunology, 160, 2998-3005.
Hofstra, C. L., Savelkoul, H. F. J., van Ark, I., Nijkamp, F. P., & van Oosterhout, A. J. M. (1998). V*8+ T lymphocytes regulate airway hyperresponsiveness, bronchoalveolar lavage eosinophilia and allergen-specific IgE in a murine model of allergic asthma. Clinical and Experimental Allergy, 28, 1571-1580.
van Oosterhout, A. J. M., Lobato-van Esch, E. C. A. M., Hofman, G. A., Hofstra, C. L., van Ark, I., Nijkamp, F. P., Kapsenberg, M. L., Savelkoul, H. F. J., & Weller, F. R. (1998). Allergen immunotherapy inhibits airway eosinophilia and hyperresponsiveness associated with decreased IL-4 production by lymphocytes in a murine model of allergic asthma. American Journal of Respiratory Cell and Molecular Biology, 19, 622-628.
Other output
van Oosterhout, A. J. M., Lobato-van Esch, E. C. A. M., Hofman, G. A., Hofstra, C. L., van Ark, I., Nijkamp, F. P., Kapsenberg, M. L., Savelkoul, H. F. J., & Weller, F. R. (1998). Allergen immunotherapy inhibits airway eosinophilia, hyperresponsiveness and IL-4 production in a murine model of allergic asthma. A475-A475. Abstract from Unknown event, Asilomar, USA.
Hofstra, C. L., van Ark, I., Kool, M., Nijkamp, F. P., & van Oosterhout, A. J. M. (1998). Different antigen-presenting cells required for optimal cytokine production by antigen-stimulated lymphocytes isolated from lung and lymph nodes. A270-A270. Abstract from Unknown event, Asilomar, USA.
Hofstra, C. L., van Ark, I., Nijkamp, F. P., & van Oosterhout, A. J. M. (1998). Optimal cytokine production by antigen-stimulated T cells isolated from lung versus lymphe nodes requires different APC. A627-A627. Abstract from Unknown event, Asilomar, USA.
1997
Scholarly publications
van Oosterhout, A. J. M., Hofstra, C. L., Shields, R., Chan, B., van Ark, I., Jardieu, P. M., & Nijkamp, F. P. (1997). Murine CTLA4-IgG treatment inhibits airway eosinophilia and hyperresponsiveness and attenuates IgE upregulation in a murine model of allergic asthma. American Journal of Respiratory Cell and Molecular Biology, 17, 386-392.
Hessel, E. M., van Oosterhout, A. J. M., van Ark, I., Lobato-van Esch, E. C. A. M., Hofman, G. A., van Loveren, H., Savelkoul, H. F. J., & Nijkamp, F. P. (1997). Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration. American Journal of Respiratory Cell and Molecular Biology, 16, 325-334.
Kraneveld, A. D., van Ark, I., van der Linde, H. J., Fattah, D., Nijkamp, F. P., & van Oosterhout, A. J. M. (1997). Antibody to very late activation antigen 4 prevents interleukin-5-induced airway hyperresponsiveness and eosinophil infiltration in the airways of guinea pigs. Journal of Allergy and Clinical Immunology, 100, 242-250.
Other output
Hofstra, C. L., van Ark, I., Shields, B., Chan, B., Jardieu, P. M., Nijkamp, F. P., & van Oosterhout, A. J. M. (1997). Treatment with murine CTLA4-IgG inhibits airway eosinophilia, hyperresponsiveness and attenuates IgE upregulation in a murine model of allergic asthma. 219-219. Abstract from Unknown event, Asilomar, USA.
Hofstra, C. L., Savelkoul, H. F. J., van Ark, I., Nijkamp, F. P., & van Oosterhout, A. J. M. (1997). CD4+ T cells produce Th2 type cytokines in a murine model of allergic asthma. A735-A735. Abstract from Unknown event, Asilomar, USA.
van Oosterhout, A. J. M., Hofstra, C. L., van Ark, I., Savelkoul, H. F. J., & Nijkamp, F. P. (1997). Type 2 cytokine profile of CD4+ cells from parabronchial lymph nodes in a murine model of allergic asthma. S171-S171. Abstract from Unknown event, Asilomar, USA.
Hessel, E. M., Cruikshank, W. W., van Ark, I., de Bie, J. J., Lobato-van Esch, E. C. A. M., Hofman, G. A., Nijkamp, F. P., Center, D. M., & van Oosterhout, A. J. M. (1997). IL16 is important for IgE synthesis and airway hyperresponsiveness in a mouse model for allergic asthma. S265-S265. Abstract from Unknown event, Asilomar, USA.
van Oosterhout, A. J. M., Lobato-van Esch, E. C. A. M., Hofman, G. A., van Ark, I., Nijkamp, F. P., Savelkoul, H. F. J., & Weller, F. R. (1997). Allergen immunotherapy inhibits airway eosinophilia and hyperresponsiveness and decreases IL-4 production by T-lymphocytes in a murine model of allergic asthma. 329-330. Abstract from Unknown event, Asilomar, USA.
1996
Scholarly publications
van Oosterhout, A. J. M., van Ark, I., Hofman, G., van der Linde, H. J., Fattah, D., & Nijkamp, F. P. (1996). Role of interleukin-5 and substance P in development of airway hyperreactivity to histamine in guinea-pigs. European Respiratory Journal, 9, 493-499.
Folkerts, G., Sadeghi - Hashjin, G., Henricks, P. A. J., van der Linde, H. J., van Ark, I., Verheyen, A. K. C. P., & Nijkamp, F. P. (1996). Peroxynitrite induces hyperresponsiveness of the guinea pig airways in vitro and in vivo. In J. Stamler, S. Gross, S. Moncada, & A. E. Higgs (Eds.), The Biology of Nitric Oxide (part 5) (pp. 220). Ponthart Press.
de Bie, J. J., Hessel, E. M., van Ark, I., Lobato-van Esch, E. C. A. M., Hofman, G., Nijkamp, F. P., & van Oosterhout, A. J. M. (1996). Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse. British Journal of Pharmacology, 119, 1484-1490.
Mohede, I. C. M., van Ark, I., Brons, F. M., van Oosterhout, A. J. M., & Nijkamp, F. P. (1996). Salmeterol inhibits interferon-gamma and interleukin-4 producti-on by human peripheral blood mononuclear cells. International Journal of Immunopharmacology, 18, 193-201.
Sadeghi-Hashjin, G., Folkerts, G., Henricks, P. A. J., Verheyen, A. K. C. P., Van Der Linde, H. J., Van Ark, I., Coene, A., & Nijkamp, F. P. (1996). Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo. American Journal of Respiratory and Critical Care Medicine, 153(5), 1697-1701.
Other output
Hessel, E. M., van Oosterhout, A. J. M., van Ark, I., Lobato-van Esch, E. C. A. M., Hofman, G. A., Savelkoul, H. F. J., & Nijkamp, F. P. (1996). The TH1-type cytokine IFNgamma is involved in the induction of airway hyperresponsiveness whereas IL5 is important for eosinophilia in a mouse model for allergic asthma.. Abstract from Unknown event, Asilomar, USA.
Hofstra, C. L., van Ark, I., Lobato-van Esch, E. C. A. M., Nijkamp, F. P., Jardieu, P. M., & van Oosterhout, A. J. M. (1996). Role of interferon-gamma in a murine model of allergic asthma.. Abstract from Unknown event, Asilomar, USA.
Kraneveld, A. D., van Ark, I., van der Linde, H. J., Fattah, D., Nijkamp, F. P., & van Oosterhout, A. J. M. (1996). Antibody to VLA-4 prevents IL-5-induced airway hyperresponsiveness and eosinophil accumulation in guinea pigs.. Abstract from Unknown event, Asilomar, USA.
Hofstra, C. L., van Ark, I., Lobato-van Esch, E. C. A. M., Savelkoul, H. F. J., Nijkamp, F. P., & van Oosterhout, A. J. M. (1996). Role of Vb8+ T-cells in mouse model of allergic asthma.. Abstract from Unknown event, Asilomar, USA.
Sadeghi - Hashjin, G., Folkerts, G., Henricks, P. A. J., van der Linde, H. J., Verheyen, A. K. C. P., Coene, A., van Ark, I., & Nijkamp, F. P. (1996). Peroxynitrite-induced airway hyperresponsiveness in guinea pigs is associated with increased major basic protein levels and epithelium desquamation.. Abstract from Unknown event, Asilomar, USA.
1995
Scholarly publications
Van Oosterhout, A. J. M., Van Ark, I., Folkerts, G., Van Der Linde, H. J., Savelkoul, H. F. J., Verheyen, A. K. C. P., & Nijkamp, F. P. (1995). Antibody to interleukin-5 inhibits virus-induced airway hyperresponsiveness to histamine in guinea pigs. American Journal of Respiratory and Critical Care Medicine, 151(1), 177-183.