Dr. ir. I. (Irma) Meijerman

David de Wiedgebouw
Universiteitsweg 99
Kamer 3.84
3584 CG Utrecht

Dr. ir. I. (Irma) Meijerman

Associate Professor
Pharmacology
+31 6 21 595 333
i.meijerman@uu.nl

Publications

2023

Scholarly publications

Meijerman, I., Kirschner, F., & Prins, F. (2023). Experiences with Supporting Teachers with Scholarship of Teaching and Learning at a Research-Intensive University: Lessons Learned. Teaching and Learning Inquiry, 11. https://doi.org/10.20343/teachlearninqu.11.27
Crone, V., Prins, F., Lutz, C., Meijerman, I., Schutjens, V., van der Smagt, M., Wijngaards-de Meij, L., Bovenschen, N., & Kluijtmans, M. (Accepted/In press). Strengthening educational leadership through a professional development programme in conjunction with a teaching-focused full professor career track: reflections of participants. International Journal for Academic Development. https://doi.org/10.1080/1360144X.2023.2207309
Kidwai, S., Barbiero, P., Meijerman, I., Tonda, A., Perez-Pardo, P., Lio, P., van der Maitland-Zee, A. H., Oberski, D. L., Kraneveld, A. D., & Lopez-Rincon, A. (2023). A robust mRNA signature obtained via recursive ensemble feature selection predicts the responsiveness of omalizumab in moderate-to-severe asthma. Clinical and Translational Allergy, 13(11), e12306. https://doi.org/10.1002/clt2.12306
Crone, V., Prins, F., Lutz, C. I., Meijerman, I., Schutjens, V., van der Smagt, M., Wijngaards, L., Bovenschen, N., & Kluijtmans, M. (2023). Strengthening educational leadership through a professional development programme in conjunction with a teaching-focused full professor career track: reflections of participants. International Journal for Academic Development. Advance online publication. https://doi.org/10.1080/1360144X.2023.2207309

2022

Scholarly publications

Meijerman, I., & Vangangelt, R. (2022). ISSOTL komt naar Utrecht in 2023. Lees concrete voorbeelden van SoTL-onderzoek en laatje inspireren. Onderzoek van Onderwijs, 51(3). https://www.tijdschriftovo.nl/art/50-7241_ISSOTL-komt-naar-Utrecht-in-2023

2021

Scholarly publications

Schot, W. D., Hegeman, M. A., ten Broeke, T., Valentijn, F. A., Meijerman, I., Prins, F. J., Dictus, W. J. A. G., & Bovenschen, N. (2021). A novel undergraduate biomedical laboratory course concept in synergy with ongoing faculty research. Biochemistry and Molecular Biology Education, 49(5), 758-767. https://doi.org/10.1002/bmb.21563

Professional publications

Meijerman, I., Wijsman, L., & Kirschner, F. (2021, Mar). Utrecht Roadmap for Scholarship of Teaching and Learning. Utrecht University.
https://dspace.library.uu.nl/bitstream/handle/1874/415531/Utrecht_Roadmap_for_SoTL_EN_2021_03.pdf?sequence=1

2020

Scholarly publications

Crone, V. C. A. (Author), Dilaver, G. (Author), van Haeften, T. (Author), van den Hoven, M. A. (Author), Janssen, J. J. H. M. (Author), Kluijtmans, M. (Author), Lutz, C. I. (Author), Rebel, K. T. (Author), van Royen-Kerkhof, A. (Author), Schutjens, V. A. J. M. (Author), de Vries, U. (Author), & Meijerman, I. (Author). (2020). Vijf lessen van de coronacrisis die het universitair onderwijs beter maken. Web publication/site, ScienceGuide. https://www.scienceguide.nl/2020/11/vijf-lessen-van-de-coronacrisis-die-het-universitair-onderwijs-beter-maken/

Professional publications

Meijerman, I., & Grunefeld, H. (2020). Writing your senior teaching application (SKO): tips and tricks. Utrecht University.
https://dspace.library.uu.nl/bitstream/handle/1874/418607/2020_Writing_your_senior_teaching_application_IM_HG.pdf?sequence=1

2019

Scholarly publications

Meijerman, I. (2019). Supporting teachers in doing SoTL: Development and effect of an interdisciplinary course at Utrecht University. 422-427. Paper presented at 3rd EuroSoTL Conference, Bilbao, Spain. https://www.ehu.eus/documents/8301386/10560621/Actas-EuroSoTL-Conference-2019.pdf/1a7d5867-e222-4aab-6f92-a7948f1fbd67?t=1560417459000
van Dongen, E. G. D., & Meijerman, I. (2019). Teaching a historical context in a first-year ‘Introduction to private law’ course: the effects of teaching approaches and a learning environment on students’ learning. In V. Amorosi, & V. M. Minale (Eds.), History of law and other humanities: views of the legal world across the time (pp. 551-569). (Historia del derecho = Legal history; Vol. 73). Dykinson. https://e-archivo.uc3m.es/bitstream/handle/10016/28459/history_hd73_2019.pdf

2017

Scholarly publications

Koster, A., Schalekamp, T., & Meijerman, I. (2017). Implementation of Competency-Based Pharmacy Education (CBPE). Pharmacy, 5(1), Article 10. https://doi.org/10.3390/pharmacy5010010

2016

Scholarly publications

Meijerman, I., Nab, J., & Koster, A. S. (2016). Designing and implementing an inquiry-based undergraduate curriculum in pharmaceutical sciences. Currents in Pharmacy Teaching and Learning, 8(6), 905-919. https://doi.org/10.1016/j.cptl.2016.08.001

2015

Scholarly publications

Joerger, M., Huitema, A. D. R., Boot, H., Cats, A., Doodeman, V. D., Smits, P. H. M., Vainchtein, L., Rosing, H., Meijerman, I., Zueger, M., Meulendijks, D., Cerny, T. D., Beijnen, J. H., & Schellens, J. H. M. (2015). Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy. Cancer Chemotherapy and Pharmacology, 75(4), 763-772. https://doi.org/10.1007/s00280-015-2698-7

2014

Scholarly publications

Meijerman, I. (2014). The College of Pharmaceutical Sciences. An Inquiry-Based Undergraduate Honors Program for the training of Pharmaceutical Scientists. In M. V. C. Wolfensberger, L. Drayer, & J. J. M. Volker (Eds.), Persuit of Excellence in a Networked Society.: Theoretical and Practical Approaches coming from the Conference Evoking Excellence in Higher Education and Beyond (pp. 51-56). Waxman Muenster.
Mooiman, K. D., Maas-Bakker, R. F., Hendrikx, J. J. M. A., Bank, P. C. D., Rosing, H., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2014). The effect of complementary and alternative medicines on CYP3A4-mediated metabolism of three different substrates: 7-benzyloxy-4-trifluoromethyl-coumarin, midazolam and docetaxel. Journal of Pharmacy and Pharmacology, 66(6), 865-74. https://doi.org/10.1111/jphp.12208
Mooiman, K. D., Goey, A. K. L., Huijbregts, T. J., Maas-Bakker, R. F., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2014). The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity. Journal of Pharmacy and Pharmacology, 66(9), 1339-46. https://doi.org/10.1111/jphp.12259
Goey, A. K. L., Meijerman, I., Rosing, H., Marchetti, S., Mergui-Roelvink, M., Keessen, M., Burgers, J. A., Beijnen, J. H., & Schellens, J. H. M. (2014). The effect of St John's wort on the pharmacokinetics of docetaxel. Clinical Pharmacokinetics, 53(1), 103-10.

2013

Scholarly publications

Mooiman, K. D., Maas-Bakker, R. F. M., Rosing, H., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2013). Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures. Biomedical Chromatography, 27(9), 1107-16.
Goey, A. K. L., Mooiman, K. D., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2013). Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients. Cancer Treatment Reviews, 39(7), 773-83.
Lau, C., Mooiman, K. D., Maas-Bakker, R. F. M., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2013). Effect of Chinese herbs on CYP3A4 activity and expression in vitro. Journal of Ethnopharmacology, 149(2), 543-9.
Meijerman, I., Olivier, B., & Koster, A. S. (2013). The College of Pharmaceutical Sciences, an inquiry-based undergraduate honours programme for the training of pharmaceutical scientists. In M. Wolfensberger, & et al. (Eds.), Proceedings and Working Papers of the International Conference on Evoking Excellence in Higher Education and Beyond - 2012
Goey, A. K. L., Meijerman, I., Rosing, H., Burgers, J. A., Mergui-Roelvink, M., Keessen, M., Marchetti, S., Beijnen, J. H., & Schellens, J. H. M. (2013). The effect of Echinacea purpurea on the pharmacokinetics of docetaxel. British Journal of Clinical Pharmacology, 76(3), 467-474.
Goey, A. K. L., Meijerman, I., Beijnen, J. H., & Schellens, J. H. M. (2013). The effect of grape seed extract on the pharmacokinetics of dextromethorphan in healthy volunteers. European Journal of Clinical Pharmacology, 69(11), 1883-90.
Meijerman, I., Storm, G., Moret, E. E., & Koster, A. S. (2013). Development and student evaluation of an inquiry-based elective course on drug discovery and preclinical drug development. Currents in Pharmacy Teaching and Learning, 5, 14-22. https://doi.org/10.1016/j.cptl.2012.09.009
Mooiman, K. D., Maas-Bakker, R. F. M., Moret, E. E., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2013). Milk Thistle's Active Components Silybin and Isosilybin: Novel Inhibitors of PXR-Mediated CYP3A4 Induction. Drug Metabolism and Disposition, 41, 1494-1504.
Harmsen, S., Meijerman, I., Maas-Bakker, R. F. M., Beijnen, J. H., & Schellens, J. H. M. (2013). PXR-mediated P-glycoprotein induction by small molecule tyrosine kinase inhibitors. European Journal of Pharmaceutical Sciences, 48(4-5), 644-9.

Professional publications

Verdel, B. M., Koster, A. S., Olivier, B., & Meijerman, I. (2013). The College of Pharmaceutical Sciences, a new international undergraduate honours programme for the training of pharmaceutical scientists. Pharmacy Education, 13(1), 104.

2012

Scholarly publications

Mooiman, K. D., Goey, A. K. L., Meijerman, I., Beijnen, J. H., & Schellens, J. H. M. (2012). Letter to the editor regarding "A prospective, controlled study of the botanical compound mixture LCS101 for chemotherapy-induced hematological complications in breast cancer" by Yaal-Hahoshen et al. (The Oncologist 2011;16:1197-1202). Oncologist, 17(5), 740-1; author reply 742-3.
Goey, A. K. L., Rosing, H., Meijerman, I., Sparidans, R. W., Schellens, J. H. M., & Beijnen, J. H. (2012). The bioanalysis of the major Echinacea purpurea constituents dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides in human plasma using LC-MS/MS. Journal of chromatography. B, 902, 151-156.

2011

Scholarly publications

Goey, A., Sparidans, R. W., Meijerman, I., Rosing, H., Schellens, J. H. M., & Beijnen, J. H. (2011). A sensitive LC-MS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma. Journal of chromatography. B, 879(1), 41-48. https://doi.org/10.1016/j.jchromb.2010.11.007
Antolino-Lobo, I., Meulenbelt, J., Nijmeijer, S. M., Maas-Bakker, R. F. M., Meijerman, I., van den Berg, M., & van Duursen, M. B. M. (2011). 3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition. Toxicology Letters, 203(1), 82-91. http://www.ncbi.nlm.nih.gov/pubmed/21402137

Professional publications

Meijerman, I., ten Berge, H., Wisman, G., Oussoren, C., Stroink, T., Flesch, F. M., & Koster, A. S. (2011). Interne onderwijsdifferentiatie in een bachelor Farmacie cursus. Onderzoek van Onderwijs, 40, 28-33.

2010

Scholarly publications

Meijerman, I., Grunefeld, H., Schobben, A. F. A. M., & Koster, A. S. (2010). Inventory of the employment possibilities for Bachelors of Pharmacy in the Netherlands. Pharmacy Education, 10(2), 89-96. http://pharmacyeducation.fip.org/2010/12/inventory-of-the-employment-possibilities-for-bachelors-of-pharmacy-in-the-netherlands/13/
Harmsen, S., Meijerman, I., Febus, C. L., Maas-Bakker, R. F. M., Beijnen, J. H., & Schellens, J. H. M. (2010). PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line. Cancer Chemotherapy and Pharmacology, 66(4), 771.

Other output

Antolino Lobo, I., Meulenbelt, J., Nijmeijer, S. M., Maas-Bakker, R., Meijerman, I., van Duursen, M. B. M., & van den Berg, M. (Accepted/In press). A key role for CYP3A4 in MDMA (Ecstasy)-induced hepatotoxicity and implications for acute MDMA toxicity and therapeutic drugs interactions. Abstract from NVT PHD Day - Annual meeting of the Dutch Society of Toxicology, Woudschoten, Zeist, The Netherlands.

2009

Scholarly publications

Harmsen, S., Meijerman, I., Beijnen, J. H., & Schellens, J. H. M. (2009). Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor. Cancer Chemotherapy and Pharmacology, 64(1), 35-43.

Professional publications

Koster, A. S., Meijerman, I., Blom, A. T. G., & Schalekamp, T. (2009). Pharmacy education at Utrecht university: an educational continuum. Dosis, 25, 85-93.

2008

Scholarly publications

Harmsen, S., Koster, A. S., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2008). Comparison of two immortalized human cell lines to study nuclear receptor-mediated CYP3A4 induction. Drug Metabolism and Disposition, 36(6), 1166-1171. https://doi.org/10.1124/dmd.107.017335
Meijerman, I., Beijnen, J. H., & Schellens, J. H. M. (2008). Combined action and regulation of phase II enzymes and multidrug resistance proteins in multidrug resistance in cancer. Cancer Treatment Reviews, 34(6), 505-520.

2007

Scholarly publications

Meijerman, I., Sanderson, L. M., Smits, P. H. M., Beijnen, J. H., & Schellens, J. H. M. (2007). Pharmacogenetic screening of the gene deletion and duplications of CYP2D6. Drug Metabolism Reviews, 39(1), 45-60.
Harmsen, S., Meijerman, I., Beijnen, J. H., & Schellens, J. H. M. (2007). The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology. Cancer Treatment Reviews, 33(4), 369-380.
Boschi, T. M., Meijerman, I., Smits, P. H. M., Beijnen, J. H., & Schellens, J. H. M. (2007). Pharmacogenetics of drug transporters in chemotherapeutic treatment. International Journal of Biological Markers, 22(1), 51-52.
Bosch, T. M., Meijerman, I., Beijnen, J. H., van Thiel, S. W., & Vlasveld, L. T. (2007). Lethal toxicity of uracil/tegafur in the treatment of sigmoid carcinoma. Annals of Oncology, 18(3).
Brandon, E. F. A., Sparidans, R. W., van Ooijen, R. D., Meijerman, I., Lazaro, L. L., Manzanares, I., Beijnen, J. H., & Schellens, J. H. M. (2007). In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug. Investigational New Drugs, 25, 9-19.
Meijerman, I., Bosch, T. M., Deenen, M., Pruntel, R., Smits, P. H. M., Beijnen, J. H., & Schellens, J. H. M. (2007). Pharmacogenetics of the nuclear receptors PXR and CAR and their role in oncology. International Journal of Biological Markers, 22(1), 52-53.

Professional publications

Meijerman, I., & Rodenburg, K. W. (2007). Eindtermen van het Bacheloropleiding Biomedische Wetenschappen UU, in opdracht van de Bachelor opleidingsdirecteur Dr. W.J.A.G. Dictus. Facultair Onderwijsinstituut Biologie.

2006

Scholarly publications

Meijerman, I., Beijnen, J. H., & Schellens, J. H. M. (2006). Herb-drug interactions in oncology: focus on mechanisms of induction. Oncologist, 11(7), 742-52.
Bosch, T. M., Deenen, M., Pruntel, R., Smits, P. H., Schellens, J. H. M., Beijnen, J. H., & Meijerman, I. (2006). Screening for polymorphisms in the PXR gene in a Dutch population. European Journal of Clinical Pharmacology, 62(5), 395-9.
Brandon, E. F. A., Bosch, T. M., Deenen, MJ., Levink, R., van der Wal, E., van Meerveld, JB., Bijl, M., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2006). Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines. Toxicology and Applied Pharmacology, 211(1), 1-10.
Brandon, E. F. A., Sparidans, R. W., Guijt, KJ., Lowenthal, S., Meijerman, I., Beijnen, J. H., & Schellens, J. H. M. (2006). In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Investigational New Drugs, 24(1), 3-14.
Bosch, T. M., Doodeman, VD., Smits, P. H., Meijerman, I., Schellens, J. H. M., & Beijnen, J. H. (2006). Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population. Molecular Diagnosis & Therapy, 10(3), 175-85.
Bosch, T. M., Meijerman, I., Beijnen, J. H., & Schellens, J. H. M. (2006). Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clinical Pharmacokinetics, 45(3), 253-85.

Professional publications

Feron, V. J., Groten, J. P., Hermus, R. J. J., Jonker, D., Meijerman, I., Mulder, G. J., Salmon, F., & Schoen, E. D. (2006). Designing experiments for Food-Drug Synergy: Safety Aspects. In L. U. Thompson, & W. E. Ward (Eds.), Food-Drug Synergy and Safety (pp. 431-460). Taylor & Francis.

2005

Scholarly publications

Brandon, E. F. A., Meijerman, I., Klijn, J. S., Den Arend, D., Sparidans, R. W., Lazaro, L. L., Beijnen, J. H., & Schellens, J. H. M. (2005). In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: Influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction. Anti-Cancer Drugs, 16(9), 935-943. https://doi.org/10.1097/01.cad.0000180121.16407.38
Bosch, T. M., Kjellberg, L. M., Meijerman, I., Smits, P. H. M., Schellens, J. H. M., & Beijnen, J. H. (2005). Novel identified SNPs in the main ABC transporter ABCG2 (BCRP). British Journal of Clinical Pharmacology, 59(1), 123-123.
Meijerman, I., Bosch, T., Deenen, M., Pruntel, R., Smits, P. H. M., Beijnen, J. H., & Schellens, J. H. M. (2005). Pharmacogenetic screening of the PXR gene in a Dutch population. Drug Metabolism Reviews, 37, 18-18.
Bosch, T. M., Kjellberg, L. M., Bouwers, A., Koeleman, B. P. C., Schellens, J. H. M., Beijnen, J. H., Smits, P. H., & Meijerman, I. (2005). Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population. American Journal of PharmacoGenomics, 5(2), 123-131.

2004

Scholarly publications

Brandon, E. F. A., Sparidans, R., Meijerman, I., Manzanares, I., Beijnen, J. H., & Schellens, J. H. M. (2004). In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug. Investigational New Drugs, 22(3), 241-251. https://doi.org/10.1023/B:DRUG.0000026250.34645.7f
Schalekamp, T., Oosterhof, M., van Meegen, E., van Der Meer, F. J. M., Conemans, J., Hermans, M., Meijerman, I., & de Boer, A. (2004). Effects of cytochrome P450 2C9 polymorphisms on phenprocoumon anticoagulation status. Clinical Pharmacology and Therapeutics, 76(5), 409-417. https://doi.org/10.1016/j.clpt.2004.08.006

2003

Scholarly publications

Brandon, E. F. A., Raap, C. D., Meijerman, I., Beijnen, J. H., & Schellens, J. H. M. (2003). An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons. Toxicology and Applied Pharmacology, 189, 233-246.