Publications
2025
Scholarly publications
Mimoso, C. A., Vlaming, H., de Wagenaar, N. P., Siegenfeld, A. P., & Adelman, K. (2025). Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci. Genes and Development. Advance online publication. [DOI]
2022
Scholarly publications
Kwesi-Maliepaard, E. M., Malik, M., Welsem, T. V., Doorn, R. V., Vermeer, M. H., Vlaming, H., Jacobs, H., & van Leeuwen, F. (2022). DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors in vitro. Frontiers in Genetics, 13, Article 1032958. [DOI]
Vlaming, H., Mimoso, C. A., Field, A. R., Martin, B. J. E., & Adelman, K. (2022). Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential. Nature Structural and Molecular Biology, 29(6), 613–620. [DOI]
2021
Scholarly publications
Kollenstart, L., van der Horst, S. C., Vreeken, K., Janssen, G. M. C., Martino, F., Vlaming, H., van Veelen, P. A., van Leeuwen, F., & van Attikum, H. (2021). Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies. Scientific Reports, 11(1). [DOI]
Cucinotta, C. E., Martin, B. J. E., González, M. N., Raman, P., Teif, V. B., & Vlaming, H. (2021). Strength is in engagement: The rise of an online scientific community during the COVID‐19 pandemic. EMBO Reports, 22(5). [DOI]
2020
Scholarly publications
Kwesi-Maliepaard, E. M., Aslam, M. A., Alemdehy, M. F., Brand, T. V. D., McLean, C., Vlaming, H., Welsem, T. V., Korthout, T., Lancini, C., Hendriks, S., Ahrends, T., Dinther, D. V., Haan, J. M. M. D., Borst, J., Wit, E. D., van Leeuwen, F., & Jacobs, H. (2020). The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8 + T cells. Proceedings of the National Academy of Sciences, 117(34). [DOI]
2019
Scholarly publications
Vlaming, H., McLean, C. M., Korthout, T., Alemdehy, M. F., Hendriks, S., Lancini, C., Palit, S., Klarenbeek, S., Kwesi-Maliepaard, E. M., Molenaar, T. M., Hoekman, L., Schmidlin, T. T., Altelaar, AF. M., van Welsem, T., Dannenberg, J. H., Jacobs, H., & van Leeuwen, F. (2019). Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma. EMBO Journal, 38(14), Article e101564. [DOI]
2018
Scholarly publications
van Welsem, T., Korthout, T., Ekkebus, R., Morais, D., Molenaar, T. M., Van Harten, K., Poramba-Liyanage, D., Sun, S. M., Lenstra, T. L., Srivas, R., Ideker, T., Holstege, F. C. P., van Attikum, H., El Oualid, F., Ovaa, H., Stulemeijer, I. J. E., Vlaming, H., & van Leeuwen, F. (2018). Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism. Nucleic Acids Research, 46(21). [DOI]
2017
Scholarly publications
De Vos, D., Vlaming, H., Bakker, B. M., & van Leeuwen, F. (2017). Modeling Distributive Histone Modification by Dot1 Methyltransferases: From Mechanism to Biological Insights. In Epigenetics and Systems Biology Elsevier. [DOI]
2016
Scholarly publications
Vlaming, H., & van Leeuwen, F. (2016). The upstreams and downstreams of H3K79 methylation by DOT1L. Chromosoma, 125(4).
Vlaming, H., Molenaar, T., van Welsem, T., Poramba-Liyanage, D., Smith, D., Velds, A., Hoekman, L., Korthout, T., Hendriks, S., Altelaar, A. F. M., & van Leeuwen, F. (2016). Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1. eLife, 5(e18919), 1-22. [DOI] [Repository]
2015
Scholarly publications
Zimberlin, CD., Lancini, C., Sno, R., Rosekrans, SL., McLean, CM., Vlaming, H., van, D. B. GR., Bots, M., Medema, JP., Medema, J. P., & Dannenberg, JH. (2015). HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis. FASEB Journal, 29(5). [DOI]
Hustedt, N., Seeber, A., Sack, R., Tsai-Pflugfelder, M., Bhullar, B., Vlaming, H., van Leeuwen, F., Guénolé, A., van Attikum, H., Srivas, R., Ideker, T., Shimada, K., & Gasser, S. M. (2015). Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling. Molecular Cell, 57(2). [DOI]
Stulemeijer, I. J. E., De Vos, D., Van Harten, K., Joshi, O. K., Blomberg, O., Van Welsem, T., Terweij, M., Vlaming, H., De Graaf, E. L., Altelaar, A. F. M., Bakker, B. M., & Van Leeuwen, F. (2015). Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties. Scientific Reports, 5, Article 9824. [DOI] [Repository]
2014
Scholarly publications
Vlaming, H., van Welsem, T., de Graaf, E. L., Ontoso, D., Altelaar, A. F. M., San-Segundo, P. A., Heck, A. J. R., & van Leeuwen, F. (2014). Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo. EMBO Reports, 15(10), 1077-84. [DOI]
2012
Scholarly publications
Vlaming, H., & van Leeuwen, F. (2012). Crosstalk between aging and the epigenome. Epigenomics, 4(1). [DOI]