Publications
2023
Scholarly publications
Javed, A., Balhuizen, M. D., Pannekoek, A., Bikker, F. J., Heesterbeek, D. A. C., Haagsman, H. P., Broere, F., Weingarth, M., & Veldhuizen, E. J. A. (2023). Effects of
Escherichia coli LPS Structure on Antibacterial and Anti-Endotoxin Activities of Host Defense Peptides. Pharmaceuticals (Basel, Switzerland), 16(10). https://doi.org/10.3390/ph16101485
van Dijk, A., Guabiraba, R., Bailleul, G., Schouler, C., Haagsman, H. P., & Lalmanach, A-C. (2023). Evolutionary diversification of defensins and cathelicidins in birds and primates. Molecular Immunology, 157, 53-69. https://doi.org/10.1016/j.molimm.2023.03.011
Pérez-Ortega, J., van Harten, R. M., Haagsman, H. P., & Tommassen, J. (2023). Physiological consequences of inactivation of lgmB and lpxL1, two genes involved in lipid A synthesis in Bordetella bronchiseptica. Research in Microbiology, 174(5), Article 104049. https://doi.org/10.1016/j.resmic.2023.104049
Kunchala, S. R., van Dijk, A., Veldhuizen, E. J. A., Donnellan, S. C., Haagsman, H. P., & Orgeig, S. (2023). Avian surfactant protein (SP)-A2 first arose in an early tetrapod before the divergence of amphibians and gradually lost the collagen domain. Developmental and Comparative Immunology, 139, 1-14. Article 104582. https://doi.org/10.1016/j.dci.2022.104582
2022
Scholarly publications
Le Guern, F., Gaucher, A., Cosentino, G., Lagune, M., Haagsman, H. P., Roux, A-L., Prim, D., & Rottman, M. (2022). Labeled TEMPO-Oxidized Mannan Differentiates Binding Profiles within the Collectin Families. International Journal of Molecular Sciences, 23(24), Article 16067. https://doi.org/10.3390/ijms232416067
van Dijk, A., Anten, J., Bakker, A., Evers, N., Hoekstra, A. T., Chang, J-C., Scheenstra, M. R., Veldhuizen, E. J. A., Netea, M. G., Berkers, C. R., & Haagsman, H. P. (2022). Innate Immune Training of Human Macrophages by Cathelicidin Analogs. Frontiers in Immunology, 13, 1-18. Article 777530. https://doi.org/10.3389/fimmu.2022.777530
van Os, N., Javed, A., Broere, F., van Dijk, A., Balhuizen, M. D., van Eijk, M., Rooijakkers, S. H. M., Bardoel, B. W., Heesterbeek, D. A. C., Haagsman, H. P., & Veldhuizen, E. J. A. (2022). Novel insights in antimicrobial and immunomodulatory mechanisms of action of PepBiotics CR-163 and CR-172. Journal of Global Antimicrobial Resistance, 30, 406-413. https://doi.org/10.1016/j.jgar.2022.07.009
Balhuizen, M. D., Versluis, C. M., van Grondelle, M. O., Veldhuizen, E. J. A., & Haagsman, H. P. (2022). Modulation of outer membrane vesicle-based immune responses by cathelicidins. Vaccine, 40(16), 2399-2408. https://doi.org/10.1016/j.vaccine.2022.03.015
de Jonge, E. F., van Boxtel, R., Balhuizen, M. D., Haagsman, H. P., & Tommassen, J. (2022). Pal depletion results in hypervesiculation and affects cell morphology and outer-membrane lipid asymmetry in bordetellae. Research in Microbiology, 173(4-5), 1-13. Article 103937. https://doi.org/10.1016/j.resmic.2022.103937
Cesaro, A., Torres, M. D. T., Gaglione, R., Dell'Olmo, E., Di Girolamo, R., Bosso, A., Pizzo, E., Haagsman, H. P., Veldhuizen, E. J. A., de la Fuente-Nunez, C., & Arciello, A. (2022). Synthetic Antibiotic Derived from Sequences Encrypted in a Protein from Human Plasma. ACS Nano, 16(2), 1880-1895. https://doi.org/10.1021/acsnano.1c04496
Harten, R. M. V., Bokhoven, J. L. M. T., Greeff, A. D., Balhuizen, M. D., Dijk, A. V., Veldhuizen, E. J. A., Haagsman, H. P., & Scheenstra, M. R. (2022). d-enantiomers of CATH-2 enhance the response of macrophages against Streptococcus suis serotype 2. Journal of Advanced Research, 36, 101-112. https://doi.org/10.1016/j.jare.2021.05.009
van Harten, R. M., Veldhuizen, E. J. A., Haagsman, H. P., & Scheenstra, M. R. (2022). The cathelicidin CATH-2 efficiently neutralizes LPS- and E. coli-induced activation of porcine bone marrow derived macrophages. Veterinary Immunology and Immunopathology, 244, 1-8. Article 110369. https://doi.org/10.1016/j.vetimm.2021.110369
Verheije, M. H., Coorens, M., Weerts, E. A. W. S., Berends, A. J., van Harten, R. M., Angel, M., Kooij, J., Ordonez, S. R., van Beurden, S. J., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2022). Antiviral activity of selected cathelicidins against infectious bronchitis virus. Peptide Science, 114(1), 1-8. Article e24234. https://doi.org/10.1002/pep2.24234
2021
Scholarly publications
Balhuizen, M. D., van Dijk, A., Jansen, J. W. A., van de Lest, C. H. A., Veldhuizen, E. J. A., & Haagsman, H. P. (2021). Outer Membrane Vesicles Protect Gram-Negative Bacteria against Host Defense Peptides. mSphere, 6(4), 1-14. Article e0052321. https://doi.org/10.1128/mSphere.00523-21
van Eijk, M., van Dijk, A., van der Ent, C. K., Arets, H. G. M., Breukink, E., van Os, N., Adrichem, R., van der Water, S., Gomez, R. L., Kristensen, M., Hessing, M., Jekhmane, S., Weingarth, M., Veldhuizen, R. A. W., Veldhuizen, E. J. A., & Haagsman, H. P. (2021). PepBiotics, novel cathelicidin-inspired antimicrobials to fight pulmonary bacterial infections. Biochimica et Biophysica Acta - General Subjects, 1865(9), Article 129951. https://doi.org/10.1016/j.bbagen.2021.129951
Pérez-Ortega, J., Van Harten, R. M., Van Boxtel, R., Plisnier, M., Louckx, M., Ingels, D., Haagsman, H. P., & Tommassen, J. (2021). Reduction of endotoxicity in Bordetella bronchiseptica by lipid A engineering: Characterization of lpxL1 and pagP mutants. Virulence, 12(1), 1452-1468. https://doi.org/10.1080/21505594.2021.1929037
Dell'Olmo, E., Gaglione, R., Cesaro, A., Cafaro, V., Teertstra, W. R., de Cock, H., Notomista, E., Haagsman, H. P., Veldhuizen, E. J. A., & Arciello, A. (2021). Host defence peptides identified in human apolipoprotein B as promising antifungal agents. Applied Microbiology and Biotechnology, 105(5), 1953-1964. https://doi.org/10.1007/s00253-021-11114-3
Balhuizen, M. D., Veldhuizen, E. J. A., & Haagsman, H. P. (2021). Outer Membrane Vesicle Induction and Isolation for Vaccine Development. Frontiers in Microbiology, 12, 1-14. Article 629090. https://doi.org/10.3389/fmicb.2021.629090
Balhuizen, M. D., Versluis, C. M., Van Harten, R. M., De Jonge, E. F., Brouwers, J. F., Van De Lest, C. H. A., Veldhuizen, E. J. A., Tommassen, J., & Haagsman, H. P. (2021). PMAP-36 reduces the innate immune response induced by Bordetella bronchiseptica-derived outer membrane vesicles. Current Research in Microbial Sciences, 2, Article 100010. https://doi.org/10.1016/j.crmicr.2020.100010
De Jonge, E. F., Balhuizen, M. D., Van Boxtel, R., Wu, J., Haagsman, H. P., & Tommassen, J. (2021). Heat shock enhances outer-membrane vesicle release in Bordetella spp. Current Research in Microbial Sciences, 2, 1-11. Article 100009. https://doi.org/10.1016/j.crmicr.2020.100009
2020
Scholarly publications
Peng, L., van den Biggelaar, R. H. G. A., Jansen, C. A., Haagsman, H. P., & Veldhuizen, E. J. A. (2020). A method to differentiate chicken monocytes into macrophages with proinflammatory properties. Immunobiology, 225(6), Article 152004. https://doi.org/10.1016/j.imbio.2020.152004
Peng, L., Scheenstra, M. R., van Harten, R. M., Haagsman, H. P., & Veldhuizen, E. J. A. (2020). The immunomodulatory effect of cathelicidin-B1 on chicken macrophages. Veterinary Research, 51(1), Article 122. https://doi.org/10.1186/s13567-020-00849-y
Scheenstra, M. R., van Harten, R. M., Veldhuizen, E. J. A., Haagsman, H. P., & Coorens, M. (2020). Cathelicidins Modulate TLR-Activation and Inflammation. Frontiers in Immunology, 11, Article 1137. https://doi.org/10.3389/fimmu.2020.01137
van Eijk, M., Boerefijn, S., Rosa, M., Morren, M. J. H., van der Ent, C. K., Kraak, B., Dijksterhuis, J., Valdes Barrera, I. D., Haagsman, H. P., & de Cock, H. (2020). Cathelicidin-inspired antimicrobial peptides as novel antifungal compounds. Medical Mycology, 58(8), 1073–1084. https://doi.org/10.1093/mmy/myaa014
Peng, L., Du, W., Balhuizen, M. D., Haagsman, H. P., de Haan, C. A. M., & Veldhuizen, E. J. A. (2020). Antiviral Activity of Chicken Cathelicidin B1 Against Influenza A Virus. Frontiers in Microbiology, 11, Article 426. https://doi.org/10.3389/fmicb.2020.00426
Mookherjee, N., Anderson, M. A., Haagsman, H. P., & Davidson, D. J. (2020). Antimicrobial host defence peptides: functions and clinical potential. Nature Reviews. Drug Discovery. https://doi.org/10.1038/s41573-019-0058-8
Kraaij, M. D., van Dijk, A., Scheenstra, M. R., van Harten, R. M., Haagsman, H. P., & Veldhuizen, E. J. A. (2020). Chicken CATH-2 increases antigen presentation markers on chicken monocytes and macrophages. Protein and Peptide Letters, 27(1), 60-66. https://doi.org/10.2174/0929866526666190730125525
https://dspace.library.uu.nl/bitstream/handle/1874/389132/Kraaij_et_al_revised.docx?sequence=3
https://dspace.library.uu.nl/bitstream/handle/1874/389132/Kraaij_et_al_revised.docx?sequence=3
2019
Scholarly publications
Fingerhut, L., Ohnesorge, B., von Borstel, M., Schumski, A., Strutzberg-Minder, K., Mörgelin, M., Deeg, C. A., Haagsman, H. P., Beineke, A., von Köckritz-Blickwede, M., & de Buhr, N. (2019). Neutrophil Extracellular Traps in the Pathogenesis of Equine Recurrent Uveitis (ERU). Cells, 8(12), Article 1528. https://doi.org/10.3390/cells8121528
van Eijk, M., Hillaire, M. L. B., Rimmelzwaan, G. F., Rynkiewicz, M. J., White, M. R., Hartshorn, K. L., Hessing, M., Koolmees, P. A., Tersteeg, M. H., van Es, M. H., Meijerhof, T., Huckriede, A., & Haagsman, H. P. (2019). Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain. Frontiers in Immunology, 10, Article 2476. https://doi.org/10.3389/fimmu.2019.02476
Mol, N., Peng, L., Esnault, E., Quéré, P., Haagsman, H. P., & Veldhuizen, E. J. A. (2019). Avian pathogenic Escherichia coli infection of a chicken lung epithelial cell line. Veterinary Immunology and Immunopathology, 210, 55-59. https://doi.org/10.1016/j.vetimm.2019.03.007
Scheenstra, M. R., van den Belt, M., Tjeerdsma-van Bokhoven, J. L. M., Schneider, V. A. F., Ordonez, S. R., van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2019). Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action. Scientific Reports, 9(1), 4780. https://doi.org/10.1038/s41598-019-41246-6
Ordonez, S. R., van Eijk, M., Escobar Salazar, N., de Cock, H., Veldhuizen, E. J. A., & Haagsman, H. P. (2019). Antifungal activities of surfactant protein D in an environment closely mimicking the lung lining. Molecular Immunology, 105, 260-269. https://doi.org/10.1016/j.molimm.2018.12.003
2018
Scholarly publications
Favier, A-L., Reynard, O., Gout, E., van Eijk, M., Haagsman, H. P., Crouch, E., Volchkov, V., Peyrefitte, C., & Thielens, N. M. (2018). Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction. Viruses, 11(1), Article 15. https://doi.org/10.3390/v11010015
van Harten, R. M., van Woudenbergh, E., van Dijk, A., & Haagsman, H. P. (2018). Cathelicidins: Immunomodulatory Antimicrobials. Vaccines, 6(3), Article 63. https://doi.org/10.3390/vaccines6030063
Chen, H., Wubbolts, R. W., Haagsman, H. P., & Veldhuizen, E. J. A. (2018). Inhibition and Eradication of Pseudomonas aeruginosa Biofilms by Host Defence Peptides. Scientific Reports, 8(1), Article 10446. https://doi.org/10.1038/s41598-018-28842-8
van Dijk, A., Hedegaard, C. J., Haagsman, H. P., & Heegaard, P. M. H. (2018). The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production. Veterinary Research, 49(1), Article 68. https://doi.org/10.1186/s13567-018-0558-2
Peng, L., Matthijs, M. G. R., Haagsman, H. P., & Veldhuizen, E. J. A. (2018). Avian pathogenic Escherichia coli-induced activation of chicken macrophage HD11 cells. Developmental and Comparative Immunology, 87, 75-83. https://doi.org/10.1016/j.dci.2018.05.019
Cuperus, T., Kraaij, M. D., Zomer, A. L., van Dijk, A., & Haagsman, H. P. (2018). Immunomodulation and effects on microbiota after in ovo administration of chicken cathelicidin-2. PLoS One, 13(6), Article e0198188. https://doi.org/10.1371/journal.pone.0198188
van Eijk, M., Rynkiewicz, M. J., Khatri, K., Leymarie, N., Zaia, J., White, M. R., Hartshorn, K. L., Cafarella, T. R., van Die, I., Hessing, M., Seaton, B. A., & Haagsman, H. P. (2018). Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus. Journal of Biological Chemistry, 293(27), 10646–10662. https://doi.org/10.1074/jbc.RA117.001430
Gao, J., Scheenstra, M. R., van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2018). A new and efficient culture method for porcine bone marrow-derived M1- and M2-polarized macrophages. Veterinary Immunology and Immunopathology, 200, 7-15. https://doi.org/10.1016/j.vetimm.2018.04.002
2017
Scholarly publications
Bosso, A., Pirone, L., Gaglione, R., Pane, K., Del Gatto, A., Zaccaro, L., Di Gaetano, S., Diana, D., Fattorusso, R., Pedone, E., Cafaro, V., Haagsman, H. P., van Dijk, A., Scheenstra, M. R., Zanfardino, A., Crescenzi, O., Arciello, A., Varcamonti, M., Veldhuizen, E. J. A., ... Pizzo, E. (2017). A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 β-like: from in silico identification to experimental evidence. Biochimica et Biophysica Acta - General Subjects, 1861(9), 2342-2353. https://doi.org/10.1016/j.bbagen.2017.04.009
Zhang, W., Bouwman, K. M., van Beurden, S. J., Ordonez, S. R., van Eijk, M., Haagsman, H. P., Verheije, M. H., & Veldhuizen, E. J. A. (2017). Chicken mannose binding lectin has antiviral activity towards infectious bronchitis virus. Virology, 509, 252-259. https://doi.org/10.1016/j.virol.2017.06.028
Coorens, M., Schneider, V. A. F., de Groot, A. M., van Dijk, A., Meijerink, M., Wells, J. M., Scheenstra, M. R., Veldhuizen, E. J. A., & Haagsman, H. P. (2017). Cathelicidins Inhibit Escherichia coli-Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner. Journal of Immunology, 199(4), 1418-1428. https://doi.org/10.4049/jimmunol.1602164
Kraaij, M. D., van Dijk, A., & Haagsman, H. P. (2017). CATH-2 and LL-37 increase mannose receptor expression, antigen presentation and the endocytic capacity of chicken mononuclear phagocytes. Molecular Immunology, 90, 118-125. https://doi.org/10.1016/j.molimm.2017.07.005
Coorens, M., Banaschewski, B. J. H., Baer, B. J., Yamashita, C. M., van Dijk, A., Haagsman, H. P., Veldhuizen, R. A. W., & Veldhuizen, E. J. A. (2017). Killing of Pseudomonas aeruginosa by chicken cathelicidin-2 is immunogenically silent, preventing lung inflammation in vivo. Infection and Immunity, 58(12), Article e00546-17. https://doi.org/10.1128/IAI.00546-17
Schneider, V. A. F., Coorens, M., Tjeerdsma-van Bokhoven, J. L. M., Posthuma, G., van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2017). Imaging the Antistaphylococcal Activity of CATH-2: Mechanism of Attack and Regulation of Inflammatory Response. mSphere, 2(6), Article e00370-17. https://doi.org/10.1128/mSphere.00370-17
Banaschewski, B. J. H., Baer, B., Arsenault, C., Jazey, T., Veldhuizen, E. J. A., Delport, J., Gooyers, T., Lewis, J. F., Haagsman, H. P., Veldhuizen, R. A. W., & Yamashita, C. M. (2017). The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens. Scientific Reports, 7(1), Article 15545. https://doi.org/10.1038/s41598-017-15558-4
Ordonez, S. R., Veldhuizen, E. J. A., van Eijk, M., & Haagsman, H. P. (2017). Role of Soluble Innate Effector Molecules in Pulmonary Defense against Fungal Pathogens. Frontiers in Microbiology, 8, Article 2098. https://doi.org/10.3389/fmicb.2017.02098
Veldhuizen, E. J. A., Scheenstra, M. R., Tjeerdsma-van Bokhoven, J. L. M., Coorens, M., Schneider, V. A. F., Bikker, F. J., van Dijk, A., & Haagsman, H. P. (2017). Antimicrobial and immunomodulatory activity of PMAP-23 derived peptides. Protein and Peptide Letters, 24(7). https://doi.org/10.2174/0929866524666170428150925
Schrumpf, J. A., Amatngalim, G. D., Veldkamp, J. B., Verhoosel, R. M., Ninaber, D. K., Ordonez Alvarez, S., van der Does, A. M., Haagsman, H. P., & Hiemstra, P. S. (2017). Pro-inflammatory Cytokines Impair Vitamin D-induced Host Defense in Cultured Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology, 692-693. https://doi.org/10.1165/rcmb.2016-0289OC
Brinkhof, B., van Tol, H. T. A., Groot Koerkamp, M. J. A., Wubbolts, R. W., Haagsman, H. P., & Roelen, B. A. J. (2017). Characterization of bovine embryos cultured under conditions appropriate for sustaining human naïve pluripotency. PLoS One, 12(2), Article e0172920. https://doi.org/10.1371/journal.pone.0172920
Amatngalim, G. D., Schrumpf, J. A., Henic, A., Dronkers, E., Verhoosel, R. M., Ordonez, S. R., Haagsman, H. P., Fuentes, M. E., Sridhar, S., Aarbiou, J., Janssen, R. A. J., Lekkerkerker, A. N., & Hiemstra, P. S. (2017). Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke. Journal of Innate Immunity. https://doi.org/10.1159/000455193
Gaglione, R., Dell'Olmo, E., Bosso, A., Chino, M., Pane, K., Ascione, F., Itri, F., Caserta, S., Amoresano, A., Lombardi, A., Haagsman, H. P., Piccoli, R., Pizzo, E., Veldhuizen, E. J. A., Notomista, E., & Arciello, A. (2017). Novel human bioactive peptides identified in apolipoprotein B: evaluation of their therapeutic potential. Biochemical Pharmacology, 130, 34-50. https://doi.org/10.1016/j.bcp.2017.01.009
Coorens, M., Scheenstra, M. R., Veldhuizen, E. J. A., & Haagsman, H. P. (2017). Interspecies cathelicidin comparison reveals divergence in antimicrobial activity, TLR modulation, chemokine induction and regulation of phagocytosis. Scientific Reports, 7, Article 40874. https://doi.org/10.1038/srep40874
Zhang, W., van Eijk, M., Guo, H., van Dijk, A., Bleijerveld, O. B., Verheije, M. H., Wang, G., Haagsman, H. P., & Veldhuizen, E. J. A. (2017). Expression and characterization of recombinant chicken mannose binding lectin. Immunobiology, 222(3), 518-528. https://doi.org/10.1016/j.imbio.2016.10.019
Other output
van Eijk, M., van der Ent, C. K., Aerts, H. G., Kristensen, M. I., de Cock, H., van Dijk, A., Keijzer, B. J., & Haagsman, H. P. (2017). Novel antimicrobial peptides to fight infections in patients with cystic fibrosis. S13. https://doi.org/10.1016/S1569-1993(17)30198-4
2016
Scholarly publications
Schneider, V. A. F., Coorens, M., Posthuma, G., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2016). Imaging the antimicrobial mechanism(s) of cathelicidin-2. Scientific Reports, 6, Article 32948. https://doi.org/10.1038/srep32948
Cuperus, T., van Dijk, A., Matthijs, M. G. R., Veldhuizen, E. J. A., & Haagsman, H. P. (2016). Protective effect of in ovo treatment with the chicken cathelicidin analog D-CATH-2 against avian pathogenic E. coli. Scientific Reports, 6, Article 26622. https://doi.org/10.1038/srep26622
Escobar, N., Ordonez Alvarez, S., Wosten, H., Haas, P-J. A., de Cock, H., & Haagsman, H. P. (2016). Hide, Keep Quiet, and Keep Low: Properties That Make Aspergillus fumigatus a Successful Lung Pathogen. Frontiers in Microbiology, 7, 1-13. Article 438. https://doi.org/10.3389/fmicb.2016.00438
Zhang, W., Cuperus, T., van Dijk, A., Skjødt, K., Hansen, S., Haagsman, H. P., & Veldhuizen, E. J. A. (2016). Developmental regulation of chicken surfactant protein A and its localization in lung. Developmental and Comparative Immunology, 61, 80-87. https://doi.org/10.1016/j.dci.2016.03.010
Cuperus, T., van Dijk, A., Dwars, R. M., & Haagsman, H. P. (2016). Localization and developmental expression of two chicken host defense peptides: Cathelicidin-2 and avian β-defensin 9. Developmental and Comparative Immunology, 61, 48-59. https://doi.org/10.1016/j.dci.2016.03.008
Hoeksema, M., Eijk, M. V., Haagsman, H. P., & Hartshorn, K. L. (2016). Histones as mediators of host defense, inflammation and thrombosis. Future Microbiology, 11(3), 441-453. https://doi.org/10.2217/fmb.15.151
Schneider, V. A. F., van Dijk, A., van der Sar, A. M., Kraaij, M. D., Veldhuizen, E. J. A., & Haagsman, H. P. (2016). Prophylactic administration of chicken cathelicidin-2 boosts zebrafish embryonic innate immunity. Developmental and Comparative Immunology, 60, 108-114. https://doi.org/10.1016/j.dci.2016.02.023
van Dijk, A., van Eldik, M., Veldhuizen, E. J. A., Tjeerdsma-van Bokhoven, H. L. M., de Zoete, M. R., Bikker, F. J., & Haagsman, H. P. (2016). Immunomodulatory and Anti-Inflammatory Activities of Chicken Cathelicidin-2 Derived Peptides. PLoS One, 11(2), Article e0147919. https://doi.org/10.1371/journal.pone.0147919
2015
Scholarly publications
van Helden, H. P., Kuijpers, W. C., Steenvoorden, D., Go, C., Bruijnzeel, P. L., van Eijk, M., & Haagsman, H. P. (2015). Intratracheal aerosolization of endotoxin (LPS) in the rat: a comprehensive animal model to study adult (acute) respiratory distress syndrome. In Experimental lung research (pp. 297-316). (Experimental lung research; Vol. 23). https://doi.org/10.3109/01902149709039228
Coorens, M., van Dijk, A., Bikker, F., Veldhuizen, E. J. A., & Haagsman, H. P. (2015). Importance of Endosomal Cathelicidin Degradation To Enhance DNA-Induced Chicken Macrophage Activation. Journal of Immunology, 195(8), 3970-3977. https://doi.org/10.4049/jimmunol.1501242
Hoeksema, M., Tripathi, S., White, M., Qi, L., Taubenberger, J., van Eijk, M., Haagsman, H., & Hartshorn, K. L. (2015). Arginine-rich histones have strong antiviral activity for influenza A viruses. Innate Immunity. https://doi.org/10.1177/1753425915593794
Brinkhof, B., van Tol, H. T. A., Groot Koerkamp, M. J. A., Riemers, F. M., IJzer, S. G., Mashayekhi, K., Haagsman, H. P., & Roelen, B. A. J. (2015). A mRNA landscape of bovine embryos after standard and MAPK-inhibited culture conditions: a comparative analysis. BMC Genomics, 16, 277. https://doi.org/10.1186/s12864-015-1448-x
Banaschewski, B. J. H., Veldhuizen, E. J. A., Keating, E., Haagsman, H. P., Zuo, Y. Y., Yamashita, C. M., & Veldhuizen, R. A. W. (2015). Antimicrobial and Biophysical Properties of Surfactant Supplemented with an Antimicrobial Peptide for Treatment of Bacterial Pneumonia. Antimicrobial Agents and Chemotherapy, 59(6), 3075-3083. https://doi.org/10.1128/AAC.04937-14
Hillaire, M. L. B., van Eijk, M., Vogelzang-van Trierum, S. E., Nieuwkoop, N. J., van Riel, D., Fouchier, R. A. M., Kuiken, T., Osterhaus, A. D. M. E., Haagsman, H. P., & Rimmelzwaan, G. F. (2015). Assessment of the antiviral properties of recombinant surfactant protein D against influenza B virus in vitro. Virus Research, 195, 43-46. https://doi.org/10.1016/j.virusres.2014.08.019
Other output
Haagsman, H. P., van Dijk, A., & Veldhuizen, E. J. A. (2015). New CATH-2 derivatives. (Patent No. WO2015/170984).
2014
Scholarly publications
Hillaire, M. L. B., van Eijk, M., Vogelzang-van Trierum, S. E., Fouchier, R. A. M., Osterhaus, A., Haagsman, H., & Rimmelzwaan, G. F. (2014). Recombinant porcine surfactant protein D inhibits influenza A virus replication ex vivo. Virus Research, 181, 22-26. https://doi.org/10.1016/j.virusres.2013.12.032
Veldhuizen, E. J. A., Schneider, V. A. F., Agustiandari, H., Van Dijk, A., Tjeerdsma - van Bokhoven, J. L. M., Bikker, F. J., & Haagsman, H. P. (2014). Antimicrobial and immunomodulatory activities of PR-39 derived peptides. PLoS One, 9(4), Article e95939. https://doi.org/10.1371/journal.pone.0095939
Ordonez Alvarez, S., Amarullah, I. H., Wubbolts, R. W., Veldhuizen, E. J. A., & Haagsman, H. P. (2014). Fungicidal mechanisms of cathelicidins LL-37 and CATH-2 revealed by live-cell imaging. Antimicrobial Agents and Chemotherapy, 58(4), 2240-2248. https://doi.org/10.1128/AAC.01670-13
Olde Nordkamp, M. J. M., van Eijk, M., Urbanus, R. T., Bont, L. J., Haagsman, H. P., & Meyaard, L. (2014). Leukocyte-associated Ig-like receptor-1 is a novel inhibitory receptor for surfactant protein D. Journal of Leukocyte Biology, 96(1), 105-111. https://doi.org/10.1189/jlb.3AB0213-092RR
Other output
Haagsman, H., van Dijk, A., & Veldhuizen, E. (Accepted/In press). New CATH-2 derivatives. (Patent No. EP 14167718.7).
2013
Scholarly publications
Hillaire, M. L. B., Haagsman, H. P., Osterhaus, A. D., Rimmelzwaan, G. F., & van Eijk, M. (2013). Pulmonary Surfactant Protein D in First-Line Innate Defence against Influenza A Virus Infections. Journal of Innate Immunity, 197-208. https://doi.org/10.1159/000346374
Cuperus, T., Coorens, M., van Dijk, A., & Haagsman, H. P. (2013). Avian host defense peptides. Developmental and Comparative Immunology, 41, 352-369. https://doi.org/10.1016/j.dci.2013.04.019
Brinkhof, B., Roelen, B. A. J., & Haagsman, H. P. (2013). Meet the Stem Cells. In Engineering aspects of food biotechnology
Other output
van Eijk, M., & Haagsman, H. (2013). Novel polypeptide and uses thereof. (Patent No. PCT/NL2014/050720).
2012
Scholarly publications
du Puy, L., Beqqali, A., van Tol, H. T. A., Monshouwer-Kloots, J., Passier, R., Haagsman, H. P., & Roelen, B. A. J. (2012). Sarcosin (Krp1) in skeletal muscle differentiation: gene expression profiling and knockdown experiments. International Journal of Developmental Biology, 56(4), 301-9. https://doi.org/10.1387/ijdb.113327lp
Desmarais, S. M., Haagsman, H. P., & Barron, A. E. (2012). Microfabricated devices for biomolecule encapsulation. Electrophoresis, 33, 2639-2649. https://doi.org/10.1002/elps.201200189
Pezzulo, A. A., Tang, X. X., Hoegger, M. J., Abou Alaiwa, M. A., Ramachandran, S., Moninger, T. O., Karp, P. H., Wohlford-Lenane, C. L., Haagsman, H. P., van Eijk, M., Bánfi, B., Horswill, A. R., Stoltz, D. A., McCray, P. B., Welsh, M. J., & Zabner, J. (2012). Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature, 109, 109-115. https://doi.org/10.1038/nature11130
van Dijk, A., Herrebout, M., Tersteeg-Zijderveld, M. H. G., Tjeerdsma-van Bokhoven, J. L. M., Bleumink-Pluym, N., Jansman, A. J. M., Veldhuizen, E. J. A., & Haagsman, H. P. (2012). Campylobacter jejuni is highly susceptible to killing by chicken host defense peptide cathelicidin-2 and suppresses intestinal cathelicidin-2 expression in young broilers. Veterinary Microbiology, 160(3-4), 347-354. https://doi.org/10.1016/j.vetmic.2012.05.034
Hillaire, M. L. B., van Eijk, M., Nieuwkoop, N. J., Vogelzang-van Trierum, S. E., Fouchier, R. A. M., Osterhaus, A. D., Haagsman, H. P., & Rimmelzwaan, G. F. (2012). The number and position of N-linked glycosylation sites in the hemagglutinin determine differential recognition of seasonal and 2009 pandemic H1N1 influenza virus by porcine surfactant protein D. Virus Research, 169(1), 301-305.
van Eijk, M., Rynkiewicz, M. J., White, M. R., Hartshorn, K. L., Zou, X., Schulten, K., Luo, D., Crouch, E. C., Cafarella, T. R., Head, J. F., Haagsman, H. P., & Seaton, B. A. (2012). A Unique Sugar-binding Site Mediates the Distinct Anti-influenza Activity of Pig Surfactant Protein D*. Journal of Biological Chemistry, 287(32), 26666-26677. https://doi.org/10.1074/jbc.M112.368571
Inamuco, J., Veenendaal, A. K. J., Burt, S. A., Post, J. A., Tjeerdsma-van Bokhoven, J. L. M., Haagsman, H. P., & Veldhuizen, E. J. A. (2012). Sub-lethal levels of carvacrol reduce Salmonella Typhimurium motility and invasion of porcine epithelial cells. Veterinary Microbiology, 157(1-2), 200-207. https://doi.org/10.1016/j.vetmic.2011.12.021
Other output
Bikker, F. J., van Dijk, A., Mars-Groenendijk, R., Veldhuizen, E., van der Kleij, D., Haagsman, H., & Molhoek, E. M. (2012). Antimicrobial peptides based on CMAP27. (Patent No. US-2012-0093844-A1).
2011
Scholarly publications
Veldhuizen, E. J. A., van Eijk, M., & Haagsman, H. P. (2011). The carbohydrate recognition domain of collectins. The FEBS journal, 278, 3930-3941. https://doi.org/10.1111/j.1742-4658.2011.08206.x
Peters, S. J., van Helvoort, A., Kegler, D., Argiles, J. M., Luiking, Y. C., Laviano, A., van Bergenhenegouwen, J., Deutz, N. E., Haagsman, H. P., Gorselink, M., & van Norren, K. (2011). Dose-dependent effects of leucine supplementation on preservation of muscle mass in cancer cachectic mice. Oncology Reports, 26, 247-254.
Molhoek, E. M., van Dijk, A., Veldhuizen, E. J. A., Haagsman, H. P., & Bikker, F. J. (2011). A cathelicidin-2-derived peptide effectively impairs Staphylococcus epidermidis biofilms. International Journal of Antimicrobial Agents, 37, 476-479. https://doi.org/10.1016/j.ijantimicag.2010.12.020
Hillaire, M. L. B., van Eijk, M., Trierum, S. E., van Riel, D., Saelens, X., Romijn, R. A. P., Hemrika, W., Fouchier, R. A. M., Kuiken, T., Osterhaus, A. D. M. E., Haagsman, H. P., & Rimmelzwaan, G. F. (2011). Assessment of the Antiviral Properties of Recombinant Porcine SP-D against Various Influenza A Viruses In Vitro. PLoS One, 6(9), Article e25005. https://doi.org/10.1371/journal.pone.0025005
https://dspace.library.uu.nl/bitstream/handle/1874/231713/hillaire%2520et%2520al%25202011.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/231713/hillaire%2520et%2520al%25202011.pdf?sequence=1
Molhoek, E. M., van Dijk, A., Veldhuizen, E. J. A., Haagsman, H. P., & Bikker, F. J. (2011). Improved proteolytic stability of chicken cathelicidin-2 derived peptides by d-amino acid substitutions and cyclization. Peptides, 32(5), 875-880. https://doi.org/10.1016/j.peptides.2011.02.017
van Eijk, M., Bruinsma, L., Hartshorn, K. L., White, M. R., Rynkiewicz, M. J., Seaton, B. A., Hemrika, W., Romijn, R. A., van Balkom, B. W., & Haagsman, H. P. (2011). Introduction of N-Linked Glycans in the Lectin Domain of Surfactant Protein D IMPACT ON INTERACTIONS WITH INFLUENZA A VIRUSES*. Journal of Biological Chemistry, 286(23), 20137-20151. https://doi.org/10.1074/jbc.M111.224469
du Puy, L., Lopes, S. M., Haagsman, H. P., & Roelen, B. A. J. (2011). Analysis of co-expression of OCT4, NANOG and SOX2 in pluripotent cells of the porcine embryo, in vivo and in vitro. Theriogenology, 75(3), 513-526. https://doi.org/10.1016/j.theriogenology.2010.09.019
Chiang, S. C., Veldhuizen, E. J. A., Barnes, F. A., Craven, C. J., Haagsman, H. P., & Bingle, C. D. (2011). Identification and characterisation of the BPI/LBP/PLUNC-like gene repertoire in chickens reveals the absence of a LBP gene. Developmental and Comparative Immunology, 35, 285-295.
van Dijk, A., Molhoek, E. H., Bikker, F. J., Yu, P. L., Veldhuizen, E. J. A., & Haagsman, H. P. (2011). Avian cathelicidins: Paradigms for the development of anti-infectives. Veterinary Microbiology, 153, 27-36.
Wilschut, K. J., van Tol, H. T. A., Arkesteijn, G. J. A., Haagsman, H. P., & Roelen, B. A. J. (2011). Alpha 6 integrin is important for myogenic stem cell differentiation. Stem Cell Research, 7(2), 112-123. https://doi.org/10.1016/j.scr.2011.05.001
2010
Scholarly publications
Reemers, S. S. N., Veldhuizen, E. J. A., Fleming, C., van Haarlem, D. A., Haagsman, H. P., & Vervelde, L. (2010). Transcriptional expression levels of chicken collectins are effected by avian influenza A virus inoculation. Veterinary Microbiology, 141, 379-384. https://doi.org/10.1016/j.vetmic.2009.09.026
Molhoek, E. M., van Dijk, A., Veldhuizen, E. J. A., Dijk-Knijnenburg, H., Mars-Groenendijk, R. H., Boele, L. C., Kaman-van Zanten, W. E., Haagsman, H. P., & Bikker, F. J. (2010). Chicken cathelicidin-2-derived peptides with enhanced immunomodulatory and antibacterial activities against biological warfare agents. International Journal of Antimicrobial Agents, 36(3), 271-274. https://doi.org/10.1016/j.ijantimicag.2010.06.001
du Puy, L., Lopes, S. M., Haagsman, H. P., & Roelen, B. A. J. (2010). Differentiation of porcine inner cell mass cells into proliferating neural cells. Stem Cells and Development, 19, 61-70.
Wilschut, K. J., Haagsman, H. P., & Roelen, B. A. J. (2010). Extracellular matrix components direct porcine muscle stem cell behavior. Experimental Cell Research, 316(3), 341-352. https://doi.org/10.1016/j.yexcr.2009.10.014
Peters, S. J., Vanhaecke, T., Papeleu, P., Rogiers, V., Haagsman, H. P., & van Norren, K. (2010). Co-culture of primary rat hepatocytes with rat liver epithelial cells enhances interleukin-6-induced acute-phase protein response. Cell and Tissue Research, 340, 451-457. https://doi.org/10.1007/s00441-010-0955-y
https://dspace.library.uu.nl/bitstream/handle/1874/204539/Peters%2520et%2520al%25202010.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/204539/Peters%2520et%2520al%25202010.pdf?sequence=1
2009
Scholarly publications
van Damme, C. M. M., Willemse, T., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2009). Altered cutaneous expression of beta-defensins in dogs with atopic dermatitis. Molecular Immunology, 46(13), 2449-55. https://doi.org/10.1016/j.molimm.2009.05.028
Veldhuizen, E. J. A., Koomen, I., Ultee, A., van Dijk, A., & Haagsman, H. P. (2009). Salmonella serovar specific upregulation of porcine defensins 1 and 2 in a jejunal epithelial cell line. Veterinary Microbiology, 136, 69-75.
Haagsman, H. P., Hellingwerf, K. J., & Roelen, B. A. J. (2009). Production of animal proteins by cell systems, a desk-study on cultured meat. Ministerie LNV.
van Norren, K., van Helvoort, A., Argiles, J. M., van Tuijl, S., Arts, K., Gorselink, M., Laviano, A., Kegler, D., Haagsman, H. P., & van der Beek, E. M. (2009). Direct effects of doxorubicin on skeletal muscle contribute to fatigue. British Journal of Cancer, 100(2), 311-314.
van Dijk, A., Tersteeg-Zijderveld, H. G., Tjeerdsma-van Bokhoven, J. L. M., Jansman, A. J. M., Veldhuizen, E. J. A., & Haagsman, H. P. (2009). Chicken heterophils are recruited to the site of Salmonella infection and release antibacterial mature Cathelicidin-2 upon stimulation with LPS. Molecular Immunology, 46, 1517-1526.
Damme, C. M. M., Willemse, T., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2009). Altered cutaneous expression of -defensins in dogs with atopic dermatitis. Molecular Immunology, 46, 2449-2455.
du Puy, L., Beqqali, A., Monshouwer-Kloots, J., Haagsman, H. P., Roelen, B. A. J., & Passier, R. (2009). CAZIP, A Novel Protein Expressed in the Developing Heart and Nervous System. Developmental Dynamics, 238, 2903-2911.
van Dijk, A., Molhoek, E. M., Veldhuizen, E. J. A., Tjeerdsma - van Bokhoven, H., Wagendorp, E., Bikker, F., & Haagsman, H. P. (2009). Identification of chicken cathelicidin-2 core elements involved in antibacterial and immunomodulatory activities. Molecular Immunology, 46, 2465-2473.
2008
Scholarly publications
Peters, S. J., Haagsman, H. P., & van Norren, K. (2008). Arginase release by primary hepatocytes and liver slices results in rapid conversion of arginine to urea in cell culture media. Toxicology in Vitro, 22, 1094-1098.
https://dspace.library.uu.nl/bitstream/handle/1874/32178/Peters%2520et%2520al%25202008.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/32178/Peters%2520et%2520al%25202008.pdf?sequence=1
Haagsman, H. P., Hogenkamp, A., van Eijk, M., & Veldhuizen, E. J. A. (2008). Surfactant collectins and innate immunity. Neonatology, 93, 288-294.
Kuijk, E. W., Du Puy, L., Van Tol, H. T. A., Oei, C. H. Y., Haagsman, H. P., Colenbrander, B., & Roelen, B. A. J. (2008). Differences in early lineage segregation between mammals. Developmental Dynamics, 237(4), 918-927. https://doi.org/10.1002/dvdy.21480
Hogenkamp, A., Isohadouten, N., Reemers, S. S. N., Romijn, R. A., Hemrika, W., White, M. R., Tefsen, B., Vervelde, L., van Eijk, M., Veldhuizen, E. J. A., & Haagsman, H. P. (2008). Chicken lung lectin is a functional C-type lectin and inhibits haemagglutination by influenza A virus. Veterinary Microbiology, 130, 37-46.
Veldhuizen, E. J. A., Rijnders, M., Claassen, E. A., van Dijk, A., & Haagsman, H. P. (2008). Porcine ß-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria. Molecular Immunology, 45, 386-394.
van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2008). Avian defensins. Veterinary Immunology and Immunopathology, 124, 1-18.
Wilschut, K. J., Jaksani, S., van den Dolder, J., Haagsman, H. P., & Roelen, B. A. J. (2008). Isolation and characterization of porcine adult muscle-derived progenitor cells. Journal of Cellular Biochemistry, 105, 1228-1239.
2007
Scholarly publications
Veldhuizen, E. J. A., van Dijk, A., Tersteeg, M. H., Kalkhove, S. I. C., van der Meulen, J., Niewold, T. A., & Haagsman, H. P. (2007). Expression of β-defensins pBD-1 and pBD-2 along the small intestinal tract of the pig: Lack of upregulation in vivo upon Salmonella typhimurium infection. Molecular Immunology, 44(4), 276-283.
https://dspace.library.uu.nl/bitstream/handle/1874/26132/veldhuizen%2520et%2520al%25202007.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/26132/veldhuizen%2520et%2520al%25202007.pdf?sequence=2
Niewold, T. A., Veldhuizen, E. J. A., van der Meulen, J., Haagsman, H. P., de Wit, A. A. C., Smits, M. A., Tersteeg, M. H. G., & Hulst, M. M. (2007). The early transcriptional response of pig small intestinal mucosa to invasion by Salmonella enterica serovar typhimurium DT104. Molecular Immunology, 44(6), 1316-1322. https://doi.org/10.1016/j.molimm.2006.05.013
Kuijk, E. W., du Puy, L., van Tol, H. T. A., Haagsman, H. P., Colenbrander, B., & Roelen, B. A. J. (2007). Validation of reference genes for quantitative RT-PCR studies in porcine oocytes and preimplantation embryos. Developmental Biology, 7(58), 58. https://doi.org/10.1186/1471-213X-7-58
Hogenkamp, A., van Eijk, M., & Haagsman, H. P. (2007). Collectins-Interactions with pathogens. In D. Kilpatrick (Ed.), Collagen-Related Lectins in Innate Immunity (pp. 119-177). Research Signpost.
Herias, M. V., Hogenkamp, A., van Asten, A. J., Tersteeg, M. H. G., van Eijk, M., & Haagsman, H. P. (2007). Expression sites of the collectin SP-D suggest its importance in first line host defence: power of combining in situ hybridisation, RT-PCR and immunohistochemistry. Molecular Immunology, 44, 3324-3332.
Veldhuizen, E. J. A., Creutzberg, T. O., Burt, S. A., & Haagsman, H. P. (2007). Low temperature and binding to food components inhibit the antibacterial activity of carvacrol against Listeria monocytogenes in steak tartare. Journal of Food Protection, 70(9), 2127-2132. https://doi.org/10.4315/0362-028X-70.9.2127
van Dijk, A., Veldhuizen, E. J. A., Kalkhove, S. I. C., Tjeerdsma-van Bokhoven, J. L. M., Romijn, R. A., & Haagsman, H. P. (2007). The β-defensin gallinacin-6 is expressed in the chicken digestive tract and has antimicrobial activity against food-borne pathogens. Antimicrobial Agents and Chemotherapy, 51(3), 912-922.
https://dspace.library.uu.nl/bitstream/handle/1874/309938/van_Dijk_et_al_2007.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/309938/van_Dijk_et_al_2007.pdf?sequence=1
Burt, S. A., van der Zee, R., Koets, A. P., de Graaff, A. M., van Knapen, F., Gaastra, W., Haagsman, H. P., & Veldhuizen, E. J. A. (2007). Carvacrol induces heat shock protein 60 and inhibits synthesis of flagellin in Escherichia coli O157:H7. Applied and Environmental Microbiology, 73(14), 4484-4490. https://doi.org/10.1128/AEM.00340-07
Burt, S. A., Fledderman, M. J., Haagsman, H. P., van Knapen, F., & Veldhuizen, E. J. A. (2007). Inhibition of salmonella enterica serotype enteriditis on agar and raw chicken by carvacrol vapour. International Journal of Food Microbiology, 119(3), 346-350. https://doi.org/10.1016/j.ijfoodmicro.2007.05.002
Hogenkamp, A., Herías, M. V., Tooten, P. C. J., Veldhuizen, E. J. A., & Haagsman, H. P. (2007). Effects of surfactant protein D on growth, adhesion and epithelial invasion of intestinal Gram-negative bacteria. Molecular Immunology, 44(14), 3517-27. https://doi.org/10.1016/j.molimm.2007.03.013
2006
Scholarly publications
Haagsman, H. P., Hogenkamp, A., & Van Eijk, M. (2006). Collectin-mediated innate immune defense in the lung. Journal of Organ Dysfunction, 2(4), 230-236. https://doi.org/10.1080/17471060600736829
Haagsman, H. P., Hogenkamp, A., & van Eijk, M. (2006). Surfactant Proteins and Immune Function. In H. Zdenek (Ed.), Perinatal Medicine (pp. 299-304). Medimond.
Hogenkamp, A., van Eijk, M., van Dijk, A., van Asten, A. J., Veldhuizen, E. J. A., & Haagsman, H. P. (2006). Characterization and expression sites of newly identified chicken collectins. Molecular Immunology, 43(10), 1604-1606.
Los, V. T., & Haagsman, H. P. (2006). TNF-alpha inhibits adult fast myosin accumulation in myotubes. Cytokine, 35(3-4), 154-158.
Haagsman, H. P., Hogenkamp, A., & van Eijk, M. (2006). Collectin-mediated innate immune defence in the lung. Journal of Organ Dysfunction, 2(4), 230-236.
Veldhuizen, E. J. A., Hendriks, H. G. C. J. M., Hogenkamp, A., van Dijk, A., Gaastra, W., Tooten, P. C. J., & Haagsman, H. P. (2006). Differential regulation of porcine beta-defensins 1 and 2 upon Salmonella infection in the intestinal epithelial cell line IPI-2I. Veterinary Immunology and Immunopathology, 114(1-2), 94-102. https://doi.org/10.1016/j.vetimm.2006.07.012
Veldhuizen, E. J. A., Tjeerdsma - van Bokhoven, J. L. M., Zweijtzer, C., Burt, S. A., & Haagsman, H. P. (2006). Structural requirements for the antimicrobial activity of carvacrol. Journal of Agricultural and Food Chemistry, 54(5), 1874-1879.
Sultan, K. R., Henkel, B., Terlou, M., & Haagsman, H. P. (2006). Quantification of hormone-induced atrophy of large myotubes from C2C12 and L6 cells: atrophy-inducible and atrophy-resistant C2C12 myotubes. American Journal of Physiology-Cell Physiology, 290(2), C650-C659.
Other output
van Eijk, M., & Haagsman, H. P. (2006). Improved carbohydrate recognition domains (Surfactant D). (Patent No. PCT/NL2006/000159).
2005
Scholarly publications
van Dijk, A., Veldhuizen, E. J. A., van Asten, A. J. A. M., & Haagsman, H. P. (2005). CMAP27, a novel chicken cathelicidin-like antimicrobial protein. Veterinary Immunology and Immunopathology, 106, 321-327.
Burt, S. A., Vlielander, R., Haagsman, H. P., & Veldhuizen, E. J. A. (2005). Increase in activity of essential oil components carvacrol and thymol against escherichia coli 0157:H7 by addition of food stabilizers. Journal of Food Protection, 68(5), 919-926.
2004
Scholarly publications
Los, V. T., & Haagsman, H. P. (2004). Proteolytic systems and the regulation of muscle remodelling and breakdown. In Muscle development of livestock animals. Physiology, genetics and meat quality (pp. 173-199). CABI publishing.
Sultan, K. R., Tersteeg, M. H. G., Koolmees, P. A., de Baaij, J. A., Bergwerff, A. A., & Haagsman, H. P. (2004). Western blot detection of brain material in heated meat products using myelin basic protein and neuron-specific enolase as biomarkers. Analytica Chimica Acta, 520, 183-192.
van Eijk, M., White, M. R., Batenburg, J. J., Vaandrager, A. B., van Golde, L. M. G., Haagsman, H. P., & Hartshorn, K. L. (2004). Interactions of influenza A virus with sialic acids present on porcine surfactant protein D. American Journal of Respiratory Cell and Molecular Biology, 30, 871-879.
te Pas, M. F. W., Everts, M. E., & Haagsman, H. P. (2004). Muscle Development of Livestock Animals: Physiology, Genetics and Meat Quality. CABI publishing.
2003
Scholarly publications
Singh, B. P., Hendriks, H. G. C. J. M., Haagsman, H. P., Tacken, P. J., Koninkx, J. F. J. G., & van Dijk, J. E. (2003). Effects of recombinant surfactant protein D (rSP-D) on endotoxin induced changes in the metabolism of enterocyte like caco-2 cells. In Proceedings of the XI International Congress in Animal Hygiene (pp. 271-275).
Haagsman, H. P., Herias Gonzalez, L. M. V., & van Eijk, M. (2003). Surfactant phospholipids and proteins in lung defence. Acta Pharmacologica Sinica, 24, 1301-1303.
van Eijk, M., White, M. R., Crouch, E. C., Batenburg, J. J., Vaandrager, A. B., van Golde, L. M. G., Haagsman, H. P., & Hartshorn, K. L. (2003). Porcine pulmonary collectins show distinct interactions with influenza A viruses; role of the N-linked oligosaccharides in the carbohydrate recognition domain. Journal of Immunology, 171, 1431-1440.
ten Brinke, A. J., Posthuma, G., Batenburg, J. J., Haagsman, H. P., Ridder, A. N. J. A., van Golde, L. M. G., & Vaandrager, A. B. (2003). The transmembrane domain of surfactant protein C precursor determines the morphology of the induced membrane compartment in CHO cells. European Journal of Cell Biology, 82(6), 285-294.
Danlois, F., Zaltash, S., Johansson, J., Robertson, B., Haagsman, H. P., Rollin, F., Ruysschaert, J. M., & Vandenbussche, G. (2003). Pulmonary surfactant from healthy Belgian white and blue Holstein Friesian calves: biochemical and biophysical comparison. Veterinary Journal, 165, 65-72.
Professional publications
Haagsman, H. P. (2003). Stand van zaken: vlees uit het lab. Meat & Meal Management, 5, 16-17.
2002
Scholarly publications
Erasmus, M., Hofstede, G. J., Petersen, A. H., Batenburg, J. J., Haagsman, H. P., Bambang Oetomo, S., & Prop, J. (2002). SP-A enriched surfactant for treatment of rat lung transplants with SP-A deficiency after storage and reperfusion. Transplantation, 73, 348-352.
ten Brinke, A., Vaandrager, A. B., Haagsman, H. P., Ridder, A. N. J. A., van Golde, L. M. G., & Batenburg, J. J. (2002). Structural requirements for palmitoylation of surfactant protein C precursor. Biochemical Journal, 351, 663-671.
https://dspace.library.uu.nl/bitstream/handle/1874/14947/TenBrinke-Structural%2520requirements.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/14947/TenBrinke-Structural%2520requirements.pdf?sequence=1
ten Brinke, A. J., Batenburg, J. J., Haagsman, H. P., van Golde, L. M. G., & Vaandrager, A. B. (2002). Differential effect of Brefeldin A on the palmitoylation of surfactant protein C proprotein mutants. Biochemical and Biophysical Research Communications, 290, 532-538.
Diemel, R. V., Snel, M. M. E., van Golde, L. M. G., Putz, G., Haagsman, H. P., & Batenburg, J. J. (2002). Effects of Cholesterol on Surface Activity and Surface Topography of Spread Surfactant FIlms. Biochemistry, 41, 15007-15016.
Diemel, R. V., Snel, M. M. E., Waring, A. J., Walther, F. J., van Golde, L. M. G., Putz, G., Haagsman, H. P., & Batenburg, J. J. (2002). Multilayer Formation upon Compression of Surfactant Monolayers Depends on Protein Concentration as Well as Lipid Composition, an Atomic Force Microscopy Study. Journal of Biological Chemistry, 277(24), 21179-21188.
Haagsman, H. P. (2002). Structural and functional aspects of the collectin SP-A. Immunobiology, 205, 476-489.
Diemel, R. V., Walch, M., Haagsman, H. P., & Putz, G. (2002). In vitro and in vivo intrapulmonary distribution of fluorescently labeled surfactant. Critical Care Medicine, 30, 1083-1090.
Haagsman, H. P. (2002). Surfactant proteins and immune function. In - (pp. 275-276)
van Eijk, M., van de Lest, C. H. A., Batenburg, J. J., Vaandrager, A. B., Meschi, J., Hartshorn, K. L., van Golde, L. M. G., & Haagsman, H. P. (2002). Porcine surfactant protein D is N-glycosylated in its carbohydrate recognition domain and is assembled into differently charged oligomers. American Journal of Respiratory Cell and Molecular Biology, 26, 739-747.
Professional publications
Haagsman, H. P. (2002). Molecular structure of muscle proteins. Industrial Proteins, 10(3), 3-6.
2001
Scholarly publications
ten Brinke, A. J., Batenburg, J. J., Gadella, B. M., Haagsman, H. P., Vaandrager, A. B., & van Golde, L. M. G. (2001). The juxtamembrane lysine and arginine residues of surfactant protein C precursor influence palmitoylation via effects on trafficking. American Journal of Respiratory Cell and Molecular Biology, 25, 156-163.
van Rozendaal, B. A. W. M., van Golde, L. M. G., & Haagsman, H. P. (2001). Localization of functions of SP-A and SP-D at mucosal surfaces. Pediatric Pathology and Molecular Medicine, 20, 319-339.
Haagsman, H. P., & van Rozendaal, B. A. W. M. (2001). Antimicrobial defences and surfactant proteins. In J. Bourbon, A. Clement, C. Delacourt, T. Lacaze, & B. Thébaud (Eds.), Dévelopment Pulmonaire. Normal et pathologique (pp. 201-243). Editions Guigoz.
Haagsman, H. P., & Diemel, R. V. (2001). Surfactant-associated proteins: functions and structural variation. Comparative Biochemistry and Physiology A-Molecular and Integrative Physiology, 129, 91-108.
Veldhuizen, E. J. A., Diemel, R. V., Putz, G., van Golde, L. M. G., Batenburg, J. J., & Haagsman, H. P. (2001). Effect of the hydropholic surfactant proteins on the surface activity of spread films in captive bubble surfactometer. Chemistry and Physics of Lipids, 110, 47-55.
van Iwaarden, J. F., Claassen, E., Jeurissen, S. H. M., Haagsman, H. P., & Kraal, G. (2001). Alveolar macrophages, surfactant lipids, and surfactant protein B regulate the induction of immune responses via airways. American Journal of Respiratory Cell and Molecular Biology, 24, 452-548.
Diemel, R. V., van Golde, L. M. G., Bader, D., Walch, M., Hotter, B., Amann, A., Putz, G., & Haagsman, H. P. (2001). Functional tests for the characterization of surfactant protein B (SP-B) and a fluorescent SP-B analog. Archives of Biochemistry and Biophysics, 385, 338-347.
Professional publications
Sultan, K. R., & Haagsman, H. P. (2001). Species-specific primary cell cultures: a research tool in veterinary science. Veterinary Sciences Tomorrow, 1, 1-7.
Haagsman, H. P. (2001). Kwaliteit van Nederlands vlees kan veel beter. Meat & Meal Management, 10, 4-9.
2000
Scholarly publications
Veldhuizen, E. J. A., & Haagsman, H. P. (2000). Role of pulmonary surfactant components in surface film formation dynamics. Biochimica et Biophysica Acta, 1467, 255-270.
Veldhuizen, E. J. A., Batenburg, J. J., van Golde, L. M. G., & Haagsman, H. P. (2000). The role of surfactant proteins in DPPC enrichment of surface films. Biophysical Journal, 79, 3164-3171.
Danlois, F., Zaltash, S., Johansson, J., Robertson, B., Haagsman, H. P., van Eijk, M., Beers, M. F., Rollin, F., Ruysschaert, J. M., & Vandenbussche, G. (2000). Very low surfactant protein C contents in newborn Belgian White and Blue calves with respiratory distress syndrome. Biochemical Journal, 351, 779-787.
van Rozendaal, B. A. W. M., van Spriel, A. B., van de Winkel, J. G. J., & Haagsman, H. P. (2000). Role of pulmonary surfactant protein D in innate defense against Candida albicans. Journal of Infectious Diseases, 182(3), 917-922.
Lag, M., Skarpen, E., van Rozendaal, B. A. W. M., Haagsman, H. P., Huitfeldt, H. S., Thrane, E. V., & Schwarze, P. E. (2000). Cell-specific expression of CCAAT/enhancer-binding protein delta (C/EBP delta) in epithelial lung cells. Experimental Lung Research, 26, 383-399.
Pinot, F., Walti, H., Haagsman, H. P., Polla, B. S., & Bachelet, M. (2000). Curosurf modulates cAMP accumulation in human monocytes through a membrane-controlled mechanism. American journal of physiology. Lung cellular and molecular physiology, 278, L99-L104.
Veldhuizen, R. A. W., Termblay, L. M., Godvindarajan, A., van Roozendaal, W. M., Haagsman, H. P., & Sbetsky, A. S. (2000). Pulmonary surfactant is altered during mechanical ventilation of isolated rat lung. Critical Care Medicine, 28, 2545-2551.
Veldhuizen, E. J. A., Waring, A. J., Walther, F. J., Batenburg, J. J., van Golde, L. M. G., & Haagsman, H. P. (2000). Dimeric N-terminal segment of human surfactant protein B (dSP-B1-25) has enhanced surface properties compared to monomeric SP- B1-25. Biophysical Journal, 79, 377-384.
van Eijk, M., Haagsman, H. P., Skinner, T., Archibold, A., Reid, K. B. M., & Lawson, P. R. (2000). Porcine lung surfactant protein D: complementary DNA cloning, chromosomal localization and tissue distribution. Journal of Immunology, 164(3), 1442-1450. https://doi.org/10.4049/jimmunol.164.3.1442
Professional publications
Barnier, V. H. M., van Dijk, X., Haagsman, H. P., Klont, R. E., Kranen, R. W., Logtenberg, H., Mondrian, L., Vonk, T., & Westra, P. (2000). Malsheidsbepaling aan het runderkarkas. Externe opdrachtgever, vertrouwelijk.
Haagsman, H. P., & Everts, M. E. (2000). Muscle for movement and muscle for meat. Curious, 11, 7-10.
Haagsman, H. P. (2000). Samenwerking op het gebied van vleesonderzoek. VleesKrant, 13(7), 9-9.
1999
Scholarly publications
Veldhuizen, E. J., Batenburg, J. J., Vandenbussche, G., Putz, G., van Golde, L. M., & Haagsman, H. P. (1999). Production of surfactant protein C in the baculovirus expression system: the information required for correct folding and palmitoylation of SP-C is contained within the mature sequence. Biochimica et Biophysica Acta, 1416(1-2), 295-308.
1998
Scholarly publications
Nilsson, G., Gustafsson, M., Vandenbussche, G., Veldhuizen, E., Griffiths, W. J., Sjövall, J., Haagsman, H. P., Ruysschaert, J. M., Robertson, B., Curstedt, T., & Johansson, J. (1998). Synthetic peptide-containing surfactants--evaluation of transmembrane versus amphipathic helices and surfactant protein C poly-valyl to poly-leucyl substitution. European Journal of Biochemistry, 255(1), 116-24.