H.O. (Ewald) van Dyk MSc
h.o.vandyk@uu.nl
Researcher

Gegenereerd op 2018-01-19 22:08:52


Profile

Melanoma and other cancer cells present neoantigens in the form of peptide-MHCI complexes that are different from self antigens. We are interested in predicting exactly which of these antigens are sufficiently different from self and are likely to elicit an immuno responses in the context of immunotherapy.

We are also interested in predicting which T-cells are likely to bind which antigens. To be exact, given the amino acid sequence of the T-cell reseptor and the peptide-MHCI complex, what will be the bining affinity for the TCR-peptide-MHCI complex?

Gegenereerd op 2018-01-19 22:08:52
All publications
  2017 - Scholarly publications
Shugay, Mikhail, Bagaev, Dmitriy V, Zvyagin, Ivan V, Vroomans, Renske M, Crawford, Jeremy Chase, Dolton, Garry, Komech, Ekaterina A, Sycheva, Anastasiya L, Koneva, Anna E, Egorov, Evgeniy S, Eliseev, Alexey V, Van Dyk, Ewald, Dash, Pradyot, Attaf, Meriem, Rius, Cristina, Ladell, Kristin, McLaren, James E, Matthews, Katherine K, Clemens, E Bridie, Douek, Daniel C, Luciani, Fabio, van Baarle, Debbie, Kedzierska, Katherine, Kesmir, Can, Thomas, Paul G, Price, David A, Sewell, Andrew K & Chudakov, Dmitriy M (01.09.2017). VDJdb - a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research..
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Gegenereerd op 2018-01-19 22:08:53
Additional functions and activities

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Gegenereerd op 2018-01-19 22:08:53
Full name
H.O. van Dyk MSc Contact details
Hugo R. Kruytgebouw

Padualaan 8
Room Z527
3584 CH  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 4212
Gegenereerd op 2018-01-19 22:08:53
Last updated 29.09.2016