Publications
2024
Scholarly publications
Timmermans, E. P. M., Blankevoort, J., Grinwis, G. C. M., Mesu, S. J.
, Gehring, R., Delhanty, P. J. D., Maas, P. E. M., Strous, G. J.
, & Mol, J. A. (2024).
In Vivo Effects of a GHR Synthesis Inhibitor During Prolonged Treatment in Dogs.
Pharmaceuticals (Basel, Switzerland),
17(10), Article 1381.
https://doi.org/10.3390/ph17101381https://research-portal.uu.nl/ws/files/243691833/pharmaceuticals-17-01381-v3.pdf van den Berg, M. F., Bechmann, N.
, Kooistra, H. S., van Wolferen, M. E., Timmermans-Sprang, E. P. M., Peitzsch, M.
, & Galac, S. (2024).
Metabolomic profiling of pheochromocytomas in dogs: Catecholamine phenotype and tricarboxylic acid cycle metabolites.
Journal of Veterinary Internal Medicine,
38(5), 2415-2424.
https://doi.org/10.1111/jvim.17148https://research-portal.uu.nl/ws/files/241137117/Veterinary_Internal_Medicne_-_2024_-_Berg_-_Metabolomic_profiling_of_pheochromocytomas_in_dogs_Catecholamine_phenotype_and.pdf 2023
Scholarly publications
van den Berg, M. F., Kooistra, H. S., Grinwis, G. C. M., Nicoli, S.
, Golinelli, S., Stammeleer, L.
, van Wolferen, M. E., Timmermans-Sprang, E. P. M., Zandvliet, M. M. J. M., van Steenbeek, F. G., & Galac, S. (2023).
Whole transcriptome analysis of canine pheochromocytoma and paraganglioma.
Frontiers in Veterinary Science,
10, Article 1155804.
https://doi.org/10.3389/fvets.2023.1155804https://dspace.library.uu.nl/bitstream/handle/1874/430741/fvets-10-1155804.pdf?sequence=1 van der Krift, F., Zijlmans, D. W.
, Shukla, R., Javed, A., Koukos, P. I., Schwarz, L. LE.
, Timmermans-Sprang, E. P., Maas, P. E., Gahtory, D., van den Nieuwboer, M.
, Mol, J. A., Strous, G. J.
, Bonvin, A. M., van der Stelt, M.
, Veldhuizen, E. J., Weingarth, M., Vermeulen, M., Klumperman, J., & Maurice, M. M. (2023).
A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance.
Life Science Alliance,
6(11), Article e202302058.
https://doi.org/10.26508/lsa.202302058https://dspace.library.uu.nl/bitstream/handle/1874/430543/e202302058.full.pdf?sequence=12022
Scholarly publications
van der Velden, L. M., Maas, P., van Amersfoort, M.
, Timmermans-Sprang, E. P. M., Mensinga, A., van der Vaart, E., Malergue, F., Viëtor, H., Derksen, P. W. B., Klumperman, J., van Agthoven, A., Egan, D. A.
, Mol, J. A., & Strous, G. J. (2022).
Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis.
Frontiers in Endocrinology,
13, 1-14. Article 926210.
https://doi.org/10.3389/fendo.2022.926210https://dspace.library.uu.nl/bitstream/handle/1874/422312/fendo_13_926210.pdf?sequence=12021
Scholarly publications
Sanders, K., Veldhuizen, A.
, Kooistra, H. S., Slob, A., Timmermans-Sprang, E. P. M., Riemers, F. M., Daminet, S., Fracassi, F.
, van Nimwegen, S. A., Meij, B. P., & Galac, S. (2021).
Circulating MicroRNAs as Non-invasive Biomarkers for Canine Cushing's Syndrome.
Frontiers in Veterinary Science,
8, 1-12. Article 760487.
https://doi.org/10.3389/fvets.2021.760487https://dspace.library.uu.nl/bitstream/handle/1874/415840/fvets_08_760487.pdf?sequence=1 2019
Scholarly publications
Timmermans-Sprang, E., Collin, R., Henkes, A., Philipsen, M.
, & Mol, J. A. (2019).
P-cadherin mutations are associated with high basal Wnt activity and stemness in canine mammary tumor cell lines.
Oncotarget,
10(31), 2930-2946.
https://doi.org/10.18632/oncotarget.26873,
https://doi.org/10.18632https://dspace.library.uu.nl/bitstream/handle/1874/381453/Oncotarget_P_cadherin.pdf?sequence=1 2018
Scholarly publications
Verhoeven, C.
, Sprang, E. P. M., Liu, JS.
, Gracanin, A., Coelingh Bennink, H. J. T.
, & Mol, J. A. (2018).
Fetal Estetrol (E4) Inhibits Growth Hormone (GH) Signal Transduction in Breast Cancer Cell Lines.
Austin Journal of Obstetrics and Gynecology,
5(7), Article 1123.
http://austinpublishinggroup.com/obstetrics-gynecology/download.php?file=fulltext/ajog-v5-id1123.pdfhttps://dspace.library.uu.nl/bitstream/handle/1874/377591/fulltext_ajog_v5_id1123.pdf?sequence=12017
Scholarly publications
Selvarajah, G. T., Bonestroo, F. A. S.
, Timmermans Sprang, E. P. M., Kirpensteijn, J., & Mol, J. A. (2017).
Reference gene validation for gene expression normalization in canine osteosarcoma: a geNorm algorithm approach.
BMC Veterinary Research,
13, Article 354.
https://doi.org/10.1186/s12917-017-1281-3https://dspace.library.uu.nl/bitstream/handle/1874/360451/gene.pdf?sequence=1 Timmermans-Sprang, E. P. M., Gracanin, A., & Mol, J. A. (2017).
Molecular Signaling of Progesterone, Growth Hormone, Wnt, and HER in Mammary Glands of Dogs, Rodents, and Humans: New Treatment Target Identification.
Frontiers in Veterinary Science,
4, Article 53.
https://doi.org/10.3389/fvets.2017.00053https://dspace.library.uu.nl/bitstream/handle/1874/359741/progesterone.pdf?sequence=1 2015
Scholarly publications
2014
Scholarly publications
Gracanin, A., Timmermans-Sprang, E. P. M., van Wolferen, M. E., Rao, N. A. S., Grizelj, J., Vince, S., Hellmen, E.
, & Mol, J. A. (2014).
Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression.
PLoS One,
9(6), Article e98698.
https://doi.org/10.1371/journal.pone.0098698https://dspace.library.uu.nl/bitstream/handle/1874/314471/canine.pdf?sequence=1 Gracanin, A., Voorwald, F. A.
, van Wolferen, M., Timmermans-Sprang, E., & Mol, J. A. (2014).
Marginal activity of progesterone receptor B (PR-B) in dogs but high incidence of mammary cancer.
Journal of Steroid Biochemistry and Molecular Biology,
144 Pt B, 492-9.
https://doi.org/10.1016/j.jsbmb.2014.08.016 2013
Scholarly publications
Selvarajah, G., Kirpensteijn, J., Kik, M., Sprang, E. P. M., & Mol, J. (2013). Heat shock protein expression analysis in canine osteosarcoma reveals hsp90 as a potentially relevant therapeutic target. Cell Stress and Chaperones, 18(5), 607-22. Article PMC3745254.
2008
Scholarly publications
Timmermans-Sprang, E. P. M., Rao, N. A., & Mol, J. A. (2008). Transactivation of a growth hormone (GH) promoter-luciferase construct in canine mammary cells. Domestic Animal Endocrinology, 34(4), 403-410.
2002
Scholarly publications
Poffers, J.
, Lumeij, J. T., Timmermans-Sprang, E. P. M., & Redig, P. T. (2002).
Further studies on the use of allopurinol to reduce plasma uric acid concentrations in the Red-tailed Hawk (Buteo jamaicensis) hyperuricaemic model.
Avian Pathology,
31(6), 567-72.
https://doi.org/10.1080/0307945021000024634Peeters, M., Sprang, E. P. M., & Mol, J. (2002). Feline thyroid adenomas are in part associated with mutations in the G (s alpha)gene and not with polymorphisms found in the thyrotropin receptor. Thyroid, 12(7), 571-5. Article pmid12193300.
Lantinga-van Leeuwen, I. S.
, Timmermans-Sprang, E. A. P., & Mol, J. A. (2002).
Cloning and characterization of the 5'-flanking region of the canine growth hormone gene.
Molecular and Cellular Endocrinology,
197(1-2), 133-41.
https://doi.org/10.1016/s0303-7207(02)00257-51999
Scholarly publications
1998
Scholarly publications
Lumeij, J. T., Sprang, E. P., & Redig, P. T. (1998).
Further studies on allopurinol-induced hyperuricaemia and visceral gout in red-tailed hawks (Buteo jamaicensis).
Avian Pathology,
27(4), 390-3.
https://doi.org/10.1080/03079459808419356 1997
Scholarly publications
Mol, J. A., Selman, P. J., Sprang, E. P., van Neck, J. W., & Oosterlaken-Dijksterhuis, M. A. (1997). The role of progestins, insulin-like growth factor (IGF) and IGF-binding proteins in the normal and neoplastic mammary gland of the bitch: a review. Journal of reproduction and fertility. Supplement, 51, 339-44.
van Wijk, P. A., Rijnberk, A., Croughs, R. J. M., Meij, B. P., van Leeuwen, I. S., Sprang, E. P. M., & Mol, J. A. (1997). Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-depen dent hyperadrenocorticism. Journal of Endocrinological Investigation, 20, 1-7.
1995
Scholarly publications
Goossens, M. M., Meyer, H. P.
, Voorhout, G., & Sprang, E. P. (1995).
Urinary excretion of glucocorticoids in the diagnosis of hyperadrenocorticism in cats.
Domestic Animal Endocrinology,
12(4), 355-62.
https://doi.org/10.1016/0739-7240(95)00046-h1992
Scholarly publications
Van Wijk, P. A., Rijnberk, A., Croughs, R. J.
, Voorhout, G., Mol, J. A., & Sprang, E. P. M. (1992).
Corticotropin-releasing hormone and adrenocorticotropic hormone concentrations in cerebrospinal fluid of dogs with pituitary-dependent hyperadrenocorticism.
Endocrinology,
131(6), 2659-62.
https://doi.org/10.1210/endo.131.6.1332844
Prof. dr. H. Jakobgebouw
