E.J. (Elleke) van Harten MSc
E.J.vanHarten@uu.nl
Gegenereerd op 2017-06-23 14:12:25


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Synthesis, characterization and toxicity studies of luminescent nanocrystals

Promotor: Prof. dr. Andries Meijerink 
Copromotor: 
Dr. Jan Andries Post
In collaboration with: 
TNO

The last decades a lot of research has been performed on semiconductor nanocrystals and their use in applications such as LEDs, solar cells, and bio-imaging. However, an important barrier for entering the commercial market are the unknown health risks of these particles for workers, consumers, and the environment. From previous studies it is know that semiconductor nanocrystals can accumulate in the liver, spleen, and lungs of mouse [1]. However, the influence of size, composition, and surface capping of the nanocrystals on the uptake and interaction on a cellular level is still not well understood. 

In this project, the uptake and influence of semiconductor nanocrystals on living cells are studied. For these studies, luminescent CdSe and InP nanocrystals will be synthesized with various sizes and surface modifications. Subsequently, the uptake in cells will be visualized using correlative microscopy. In this technique, cells and areas of interest are pinpointed at the light microscopy level and subsequently are studied at high resolution by zooming in at these areas using transmission electron microscopy (TEM). The research will provide insight on the influence of factors like chemical composition, size, surface capping and electronic structure on the uptake and impact on a cellular level of nanocrystals. The overall aim of the project is to understand and model toxicity effects of nanocrystals to help a safe design of functional nanocrystals as well as the design of semiconductor nanocrystals that have similar or better (luminescent) properties and a significant lower toxicity compared to current state-of-the-art materials on the market.

[1] K-T. Yong et al., Chem. Soc. Rev. 42, 1236-1250 (2013)

Involved in the following study programme(s)
Gegenereerd op 2017-06-23 14:12:25
All publications
  2013 - Scholarly publications
Chin, P.T.K., van der Linden, Marte, van Harten, E.J., Barendregt, A., Rood, M.T.M., Koster, A.J., van Leeuwen, F.W.B., de Mello Donega, C., Heck, A.J.R. & Meijerink, A. (2013). Enhanced luminescence of Ag nanoclusters via surface modification. Nanotechnology, 24 (7).
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Gegenereerd op 2017-06-23 14:12:25

Synthesis, characterization and toxicity studies of luminescent nanocrystals

Promotor: Prof. dr. Andries Meijerink 
Copromotor: 
Dr. Jan Andries Post
In collaboration with: 
TNO

In this project, the uptake and influence of semiconductor nanocrystals on living cells are studied. For these studies, luminescent CdSe and InP nanocrystals will be synthesized with various sizes and surface modifications. Subsequently, the uptake in cells will be visualized using correlative microscopy. In this technique, cells and areas of interest are pinpointed at the light microscopy level and subsequently are studied at high resolution by zooming in at these areas using transmission electron microscopy (TEM). The research will provide insight on the influence of factors like chemical composition, size, surface capping and electronic structure on the uptake and impact on a cellular level of nanocrystals. The overall aim of the project is to understand and model toxicity effects of nanocrystals to help a safe design of functional nanocrystals as well as the design of semiconductor nanocrystals that have similar or better (luminescent) properties and a significant lower toxicity compared to current state-of-the-art materials on the market.

In the coming year, the main focus will be on the synthesis, functionalization, and characterization of the CdSe and InP nanocrystals. Another important aspect will be the stabilization of the nanocrystals in a cellular environment. Therefore, different post-treatment methodologies will be tested to improve the biocompatibility of the nanocrystals.

Gegenereerd op 2017-06-23 14:12:25
Full name
E.J. van Harten MSc Contact details
Leonard S. Ornsteinlaboratorium

Princetonplein 1
Room 110
3584 CC  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 2321
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Gegenereerd op 2017-06-23 14:12:25
Last updated 16.03.2015