Publications
2021
Scholarly publications
Kasteel, E. E. J., Lautz, L. S., Culot, M., Kramer, N. I., & Zwartsen, A. (2021). Application of in vitro data in physiologically-based kinetic models for quantitative in vitro-in vivo extrapolation: A case-study for baclofen. Toxicology in Vitro, 76, 1-12. [105223]. https://doi.org/10.1016/j.tiv.2021.105223
Kasteel, E. E. J., & Westerink, R. H. S. (2021). Refining in vitro and in silico neurotoxicity approaches by accounting for interspecies and interindividual differences in toxicodynamics. Expert Opinion on Drug Metabolism and Toxicology, 17(8), 1007-1017. https://doi.org/10.1080/17425255.2021.1885647
Kasteel, E. E. J. (2021). Next Generation Risk Assessment of Chemicals: In vitro and in silico approaches to work towards enough precision to make a decision. [Doctoral thesis 1 (Research UU / Graduation UU), Universiteit Utrecht]. Utrecht University. https://doi.org/10.33540/261
2020
Scholarly publications
Kasteel, E. E. J., Nijmeijer, S. M., Darney, K., Lautz, L. S., Dorne, J. L. C. M., Kramer, N. I., & Westerink, R. H. S. (2020). Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics. Archives of Toxicology, 94(12), 4055-4065. https://doi.org/10.1007/s00204-020-02927-8
Kasteel, E. E. J., Darney, K., Kramer, N. I., Dorne, J. L. C. M., & Lautz, L. S. (2020). Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors. Archives of Toxicology, 94, 2637-2661. https://doi.org/10.1007/s00204-020-02765-8
Darney, K., Kasteel, E. E. J., Buratti, F. M., Turco, L., Vichi, S., Béchaux, C., Roudot, A. C., Kramer, N. I., Testai, E., Dorne, J. L. C. M., Di Consiglio, E., & Lautz, L. S. (2020). Bayesian meta-analysis of inter-phenotypic differences in human serum paraoxonase-1 activity for chemical risk assessment. Environment international, 138, [105609]. https://doi.org/10.1016/j.envint.2020.105609
2019
Scholarly publications
Darney, K., Testai, E., Buratti, F. M., Di Consiglio, E., Kasteel, E. E. J., Kramer, N., Turco, L., Vichi, S., Roudot, A. C., Dorne, J. L., & Béchaux, C. (2019). Inter-ethnic differences in CYP3A4 metabolism: A Bayesian meta-analysis for the refinement of uncertainty factors in chemical risk assessment. Computational Toxicology, 12, [100092]. https://doi.org/10.1016/j.comtox.2019.100092
2017
Scholarly publications
Kasteel, E. E. J., & Westerink, R. H. S. (2017). Comparison of the acute inhibitory effects of Tetrodotoxin (TTX) in rat and human neuronal networks for risk assessment purposes. Toxicology Letters, 270, 12-16. https://doi.org/10.1016/j.toxlet.2017.02.014
Hondebrink, L., Kasteel, E. E. J., Tukker, A. M., Wijnolts, F. M. J., Verboven, A. H. A., & Westerink, R. H. S. (2017). Neuropharmacological characterization of the new psychoactive substance methoxetamine. Neuropharmacology, 123, 1-9. https://doi.org/10.1016/j.neuropharm.2017.04.035
2016
Scholarly publications
Tukker, A. M., de Groot, M. W. G. D. M., Wijnolts, F. M. J., Kasteel, E. E. J., Hondebrink, L., & Westerink, R. H. S. (2016). Is the time right for in vitro neurotoxicity testing using human iPSC-derived neurons? Altex, 33(3), 261-71. https://doi.org/10.14573/altex.1510091