Dr. D. (Dmitry) Lapin

Assistant Professor
Translational Plant Biology
d.lapin@uu.nl

Publications

2023

Scholarly publications

Goossens, P., Spooren, J., Baremans, K. C. M., Andel, A., Lapin, D., Echobardo, N., Pieterse, C. M. J., Van den Ackerveken, G., & Berendsen, R. L. (2023). Obligate biotroph downy mildew consistently induces near-identical protective microbiomes in Arabidopsis thaliana. Nature Microbiology, (12). Advance online publication. https://doi.org/10.1038/s41564-023-01502-y
Ogden, S. C., Nishimura, M. T., & Lapin, D. (2023). Functional diversity of Toll/interleukin-1 receptor domains in flowering plants and its translational potential. Current Opinion in Plant Biology, 76, Article 102481. https://doi.org/10.1016/j.pbi.2023.102481
Butselaar, T. V., Silva, S., Lapin, D., Banales, I., Tonn, S., Schie, C. V., & Ackerveken, G. V. D. (2023). Basal expression of immune receptor genes requires low levels of the phytohormone salicylic acid. bioRxiv. https://doi.org/10.1101/2023.07.14.548351
Griebel, T., Lapin, D., Locci, F., Kracher, B., Bautor, J., Concia, L., Benhamed, M., & Parker, J. E. (2023). Arabidopsis Topless-related 1 mitigates physiological damage and growth penalties of induced immunity. New Phytologist, 239(4), 1404-1419. https://doi.org/10.1111/nph.19054
Lapin, D. (2023). Plant immune receptors can sequester and protect host proteins from pathogen-promoted degradation. Molecular Plant, 16(6), 966-967. https://doi.org/10.1016/j.molp.2023.05.001
Goossens, P., Spooren, J., Baremans, K. C. M., Andel, A., Lapin, D., Echobardo, N., Pieterse, C. M. J., Ackerveken, G. V. D., & Berendsen, R. L. (2023). Congruent downy mildew-associated microbiomes reduce plant disease and function as transferable resistobiomes. bioRxiv. https://doi.org/10.1101/2023.03.14.532520
Johanndrees, O., Baggs, E. L., Uhlmann, C., Locci, F., Läßle, H. L., Melkonian, K., Käufer, K., Dongus, J. A., Nakagami, H., Krasileva, K. V., Parker, J. E., & Lapin, D. (2023). Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1. Plant Physiology, 191(1), 626-642. https://doi.org/10.1093/plphys/kiac480

2022

Scholarly publications

Jochems, P. G. M., Heming, B., Lapin, D., Moonen, N. E. L., Van den Ackerveken, G., & Masereeuw, R. (2022). Bioengineered intestinal tubules as a tool to test intestinal biological efficacy of lettuce species. npj Science of Food, 6(1), 1-8. Article 58. https://doi.org/10.1038/s41538-022-00175-x
Zönnchen, J., Gantner, J., Lapin, D., Barthel, K., Eschen‐Lippold, L., Erickson, J. L., Villanueva, S. L., Zantop, S., Kretschmer, C., Joosten, M. H. A. J., Parker, J. E., Guerois, R., & Stuttmann, J. (2022). EDS1 complexes are not required for PRR responses and execute TNL‐ETI from the nucleus in Nicotiana benthamiana. New Phytologist, 236(6), 2249-2264. https://doi.org/10.1111/nph.18511
Dongus, J. A., Bhandari, D. D., Penner, E., Lapin, D., Stolze, S. C., Harzen, A., Patel, M., Archer, L., Dijkgraaf, L., Shah, J., Nakagami, H., & Parker, J. E. (2022). Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity. Plant Journal, 110(5), 1415-1432. https://doi.org/10.1111/tpj.15747
Lapin, D., Johanndrees, O., Wu, Z., Li, X., & Parker, J. E. (2022). Molecular innovations in plant TIR-based immunity signaling. The Plant Cell, 34(5), 1479-1496. https://doi.org/10.1093/plcell/koac035

2021

Scholarly publications

Zönnchen, J., Gantner, J., Lapin, D., Barthel, K., Eschen-Lippold, L., Zantop, S., Kretschmer, C., Parker, J. E., Guerois, R., & Stuttmann, J. (2021). Differential requirement for the EDS1 catalytic triad in A. thaliana and N. benthamiana. (pp. 1-32). bioRxiv. https://doi.org/10.1101/2021.12.15.472806
Johanndrees, O., Baggs, E., Uhlmann, C., Locci, F., Laessle, H. L., Melkonian, K., Kaeufer, K., Dongus, J. A., Nakagami, H., Krasileva, K. V., Parker, J. E., & Lapin, D. (2021). Differential EDS1 requirement for cell death activities of plant TIR-domain proteins. (pp. 1-41). bioRxiv. https://doi.org/10.1101/2021.11.29.470438
Griebel, T., Lapin, D., Locci, F., Kracher, B., Bautor, J., Qiu, J., Concia, L., Benhamed, M., & Parker, J. E. (2021). Arabidopsis Topless-related 1 mitigates physiological damage and growth penalties of induced immunity. (pp. 1-32). bioRxiv. https://doi.org/10.1101/2021.07.07.451397
https://dspace.library.uu.nl/bitstream/handle/1874/415180/2021.07.07.451397v1.full.pdf?sequence=1
Xing, Y., Xu, N., Bhandari, D. D., Lapin, D., Sun, X., Luo, X., Wang, Y., Cao, J., Wang, H., Coaker, G., Parker, J. E., & Liu, J. (2021). Bacterial effector targeting of a plant iron sensor facilitates iron acquisition and pathogen colonization. Plant Cell, 33(6), 2015-2031. https://doi.org/10.1093/plcell/koab075
Lapin, D., Kovacova, V., Sun, X., Dongus, J. A., Bhandari, D., von Born, P., Bautor, J., Guarneri, N., Rzemieniewski, J., Stuttmann, J., Beyer, A., & Parker, J. E. (2021). Corrigendum to: A coevolved EDS1-SAG101-NRG1 module mediates cell death signaling by TIR-domain immune receptors. Plant Cell, 33(6), 2092-2092. https://doi.org/10.1093/plcell/koab085
Sun, X., Lapin, D., Feehan, J. M., Stolze, S. C., Kramer, K., Dongus, J. A., Rzemieniewski, J., Blanvillain-Baufumé, S., Harzen, A., Bautor, J., Derbyshire, P., Menke, F. L. H., Finkemeier, I., Nakagami, H., Jones, J. D. G., & Parker, J. E. (2021). Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity. Nature Communications, 12(1), 1-15. Article 3335. https://doi.org/10.1038/s41467-021-23614-x

2020

Scholarly publications

Griebel, T., Lapin, D., Kracher, B., Concia, L., Benhamed, M., & Parker, J. E. (2020). Genome-wide chromatin binding of transcriptional corepressor Topless-related 1 in Arabidopsis. (pp. 1-14). bioRxiv. https://doi.org/10.1101/2020.04.25.060855
Mahdi, L. K., Huang, M., Zhang, X., Nakano, R. T., Kopp, L. B., Saur, I. M. L., Jacob, F., Kovacova, V., Lapin, D., Parker, J. E., Murphy, J. M., Hofmann, K., Schulze-Lefert, P., Chai, J., & Maekawa, T. (2020). Discovery of a Family of Mixed Lineage Kinase Domain-like Proteins in Plants and Their Role in Innate Immune Signaling. Cell Host and Microbe, 28(6), 813-824. https://doi.org/10.1016/j.chom.2020.08.012
Harvey, S., Kumari, P., Lapin, D., Griebel, T., Hickman, R., Guo, W., Zhang, R., Parker, J. E., Beynon, J., Denby, K., & Steinbrenner, J. (2020). Downy Mildew effector HaRxL21 interacts with the transcriptional repressor TOPLESS to promote pathogen susceptibility. PLoS Pathogens, 16(8), 1-30. Article e1008835. https://doi.org/10.1371/JOURNAL.PPAT.1008835
Lapin, D., Bhandari, D. D., & Parker, J. E. (2020). Origins and Immunity Networking Functions of EDS1 Family Proteins. Annual Review of Phytopathology, 58, 253-276. https://doi.org/10.1146/annurev-phyto-010820-012840
Ma, S., Lapin, D., Liu, L., Sun, Y., Song, W., Zhang, X., Logemann, E., Yu, D., Wang, J., Jirschitzka, J., Han, Z., Schulze-Lefert, P., Parker, J. E., & Chai, J. (2020). Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science, 370(6521), 1-10. Article eabe3069. https://doi.org/10.1126/science.abe3069

2019

Scholarly publications

Lapin, D., Kovacova, V., Sun, X., Dongus, J. A., Bhandari, D., Von Born, P., Bautor, J., Guarneri, N., Rzemieniewski, J., Stuttmann, J., Beyer, A., & Parker, J. E. (2019). A coevolved EDS1-SAG101-NRG1 module mediates cell death signaling by TIR-domain immune receptors. Plant Cell, 31(10), 2430-2455. https://doi.org/10.1105/tpc.19.00118
Bhandari, D. D., Lapin, D., Kracher, B., von Born, P., Bautor, J., Niefind, K., & Parker, J. E. (2019). An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis. Nature Communications, 10(1), Article 772. https://doi.org/10.1038/s41467-019-08783-0

2013

Scholarly publications

Lapin, D., & van den Ackerveken, A. F. J. M. (2013). Susceptibility to plant disease: more than a failure of host immunity. Trends in Plant Science, 18, 546-554. https://doi.org/10.1016/j.tplants.2013.05.005
Lapin, D. (2013). Molecular aspects of plant disease susceptibility: Arabidopsis genes affecting downy mildew infection. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Utrecht University.
https://dspace.library.uu.nl/bitstream/handle/1874/286539/lapin-cd.zip?sequence=1

2012

Scholarly publications

Lapin, D., Meyer, R. C., Takahashi, H., Bechtold, U., & van den Ackerveken, A. F. J. M. (2012). Broad-spectrum resistance of Arabidopsis C24 to downy mildew is mediated by different combinations of isolate-specific loci. New Phytologist, 196(4), 1171-1181. https://doi.org/10.1111/j.1469-8137.2012.04344.x

Other output

Lapin, D., Meyer, R. C., & van den Ackerveken, A. F. J. M. (2012). Broad resistance of Arabidopsis C24 to downy mildew is mediated by different combinations of isolate-specific loci. Paper presented at 23rd International Conference on Arabidopsis Research, Vienna, Austria.
Lapin, D., Meyer, R. C., & van den Ackerveken, A. F. J. M. (2012). Genetics of broad resistance of Arabidopsis to downy mildew. Paper presented at Unknown event.
Lapin, D., Meyer, R. C., & van den Ackerveken, A. F. J. M. (2012). Broad resistance of Arabidopsis C24 to downy mildew is mediated by different combinations of isolate-specific loci. Paper presented at Unknown event.

2011

Scholarly publications

ten Hove, C. A., de Jong, H. M., Lapin, D., Andel, A., Sanchez-Perez, G. F., Tarutani, Y., Suzuki, Y., Heidstra, R., & van den Ackerveken, A. F. J. M. (2011). Trans-repression of gene activity upstream of T-DNA tagged RLK902 links Arabidopsis root growth inhibition and downy mildew resistance. PLoS One, 6(4), e19028. http://10.1371/journal.pone.0019028

Other output

Lapin, D., Meyer, R. C., & van den Ackerveken, A. F. J. M. (2011). Genetic mapping of broad resistance to downy mildew in arabidopsis C24. Paper presented at 3rd Joint Retreat of PhD Students in Plant Sciences, orsay, France.
Lapin, D., Meyer, R. C., & van den Ackerveken, A. F. J. M. (2011). Genetic mapping pf broad resistance to downy mildew in Arabidpdsis C24. Paper presented at 22nd Int. Conference on Arabidopsis Research, Madison, USA.
Lapin, D., Meyer, R. C., & van den Ackerveken, A. F. J. M. (2011). Genetic mapping of broad resistance to downy mildew in Arabidopsis C24. Paper presented at PhD Autumn School Host-Microbe Interactions, Wageningen, Netherlands.
Lapin, D., Meyer, R. C., & van den Ackerveken, A. F. J. M. (2011). Genetic mapping of broad resostance to downy mildew in Arabidopsis C24. Paper presented at Unknown event.

2010

Other output

Lapin, D., Meyer, R. C., & van den Ackerveken, A. F. J. M. (2010). Genetic mapping of broad resistane to downy mildew. Paper presented at Oomycete Molecular Genetics Network Congress, Toulouse, France.