My group performs fundamental research on RNA viruses, with a focus on enteroviruses, noroviruses, and coronaviruses. Our ultimate goal is to translate mechanistic insight into new strategies to prevent or treat viral infections. Specifically, we aim to determine the three-dimensional structures of viral proteins, and to understand how these structures underpin key steps in the viral life cycle. To achieve this, we combine cryo-electron microscopy with computational, biochemical and molecular virology approaches.

By gaining mechanistic insights into how these viruses invade, hijack, and escape host cells, we aim to identify new targets for antiviral intervention using small molecules or biologics.  Our current research interests fall into three main areas:      

1) Virus structure, receptors, and entry mechanisms   
2) Virus replication and assembly   
3) Development of antiviral drugs      

Through our work in these areas, we aim to advance understanding of viral pathogenesis and contribute to the development of effective antiviral therapies.

Research Highlights