C. (Chenghui) Xia
Gegenereerd op 2017-06-23 14:13:56


The second Near-IR region (NIR-II, 1000-1300nm) has great potential in epifluorescence imaging in vivo. This is because fluorescence in NIR-II offers deeper tissue penetration and low background autofluorescence compared to the visible region. To date, the most promising NIR-II emissive nanoprobes are limited to single-walled carbon nanotubes (SWNTs), a handful of polymethine dyes and Ag2X(S, Se) QDs.

In our work, we will investigate CuInS2 (CIS) QDs and Ag2Se QDs as Förster Resonance Energy Transfer (FRET) donor and acceptor, respectively, for in vivo experiments. The most important reason is that this kind of QDs contains no toxic heavy metal element such as Cd, Pb or Hg, and are therefore better suited for in vivo studies and for the environment. In addition, the emission wavelength of Ag2Se QDs can go up to 1300nm, while that of CIS QDs extends from 630 to 825nm, which yields deeper penetration depth and low background in tissue. Furthermore, the emission wavelength of CIS QDs can be conveniently tuned to overlap with the excitation wavelength of the acceptor, i.e. Ag2Se QDs, by controlling the nanocrystal diameter.

In the following year, we intend to fabricate a FRET system consisting of CIS QDs and Ag2Se by adding a separation layer such as a lipid corona. When the distance between the donor (D) and acceptor (A) changes, the ratio between the emission intensities of the two QDs (I Ag2Se /I CIS) will vary, since the efficiency of the FRET process is strongly dependent on dDA. The following figure gives the structure and morphology of CIS QDs that we have already synthesized.

Gegenereerd op 2017-06-23 14:13:56
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C. Xia Contact details
Leonard S. Ornsteinlaboratorium

Princetonplein 1
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The Netherlands

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Gegenereerd op 2017-06-23 14:13:56
Last updated 04.03.2016