Dr. C. (Christine) Leopold

David de Wiedgebouw
Universiteitsweg 99
3584 CG Utrecht

Dr. C. (Christine) Leopold

Assistant Professor
Pharmacoepi. and Clinical Pharmacol.
c.leopold@uu.nl

Publications

2024

Scholarly publications

Callenbach, M. H. E., Vreman, R. A., Leopold, C., Mantel-Teeuwisse, A. K., & Goettsch, W. G. (2024). Managed Entry Agreements for High-Cost, One-Off Potentially Curative Therapies: A Framework and Calculation Tool to Determine Their Suitability. PharmacoEconomics. Advance online publication. https://doi.org/10.1007/s40273-024-01433-4
Leopold, C., Vogler, S., Suleman, F., & Wirtz, V. J. (2024). P38 Strengthening primary health care through a stronger emphasis on patient and community centered medicines and pharmaceutical services. Journal of Pharmaceutical Policy and Practice, 17(1), Article 2331920. https://doi.org/10.1080/20523211.2024.2331920
Ogar, C. K., Gilbert, H. N., Bloem, L. T., Leopold, C., Bassi, P. U., Katagum, Y. M., Osakwe, A. I., Opadeyi, A. O., Oreagba, I., Mbo, D. N. D., Mantel-Teeuwisse, A. K., & De Bruin, M. L. (2024). Patient-reported outcomes of adverse events after COVID-19 vaccination in Nigeria: A mixed methods study. Vaccine, 42(23), Article 126196. https://doi.org/10.1016/j.vaccine.2024.126196

Professional publications

Leopold, C., Hagens, A., Dai, J., Tordrup, D., Dolgorsuren, S., Grafton, D., Huikuri, S., Jung, J., Roberts, E., Stanton, R., Tarlton, D., & Webb, D. (2024). Investment Case for Air Pollution Reduction in Mongolia. UNDP. https://www.undp.org/mongolia/publications/investment-case-air-pollution-reduction-mongolia
https://research-portal.uu.nl/ws/files/240725083/investment_case_of_air_pollution_reduction_in_mongolia_full_report_en.pdf
Vogler, S., Leopold, C., Suleman, F., & Wirtz, V. J. (2024). Medicines and pharmaceutical services. In Implementing the Primary Health Care approach: a primer (pp. 249-273). European Observatory on Health Systems and Policies, WHO Headquarters (HQ). https://eurohealthobservatory.who.int/publications/i/implementing-the-primary-health-care-approach-a-primer
https://research-portal.uu.nl/ws/files/227602307/PHC_book.pdf

2023

Scholarly publications

Leopold, C., Poblete, S., & Vogler, S. (2023). How to Price and to Reimburse Publicly Funded Medicines in Latin America? Lessons Learned from Europe. Medicolegal news, 51(S1), 76-91. https://doi.org/10.1017/jme.2023.114

2020

Scholarly publications

Tordrup, D., van den Ham, R., Leopold, C., Glanville, J., Kotas, E., & Mantel - Teeuwisse, A. (2020). Web Annex A: Systematic reviews for the update of the WHO Guideline on country pharmaceutical pricing policies. In WHO guideline on country pharmaceutical pricing policies World Health Organization. http://ncbi.nlm.nih.gov/books/NBK570141/
Leopold, C., Araujo-Lane, C., Rosenberg, C., Gilkey, M., & Wagner, A. K. (2020). Out-of-Pocket Cancer Care Costs and Value Frameworks: A Case Study in a Community Oncology Practice with a Financial Navigator Program. PharmacoEconomics - Open, 4(2), 389-392. https://doi.org/10.1007/s41669-019-0170-z
Leopold, C., Lu, C. Y., & Wagner, A. K. (2020). Integrating public preferences into national reimbursement decisions: a descriptive comparison of approaches in Belgium and New Zealand. BMC Health Services Research, 20(1), Article 351. https://doi.org/10.1186/s12913-020-05152-2
Leopold, C., Haffajee, R. L., Lu, C. Y., & Wagner, A. K. (2020). The Complex Cancer Care Coverage Environment - What is the Role of Legislation? A Case Study from Massachusetts. Medicolegal news, 48(3), 538-551. https://doi.org/10.1177/1073110520958879

2019

Scholarly publications

Ozawa, S., Shankar, R., Leopold, C., & Orubu, S. (2019). Access to medicines through health systems in low- and middle-income countries. Health Policy and Planning, 34(Supplement_3), iii1-iii3. https://doi.org/10.1093/heapol/czz119
Vargas, V., Leopold, C., Castillo-Riquelme, M., & Darrow, J. J. (2019). Expanding Coverage of Oncology Drugs in an Aging, Upper-Middle-Income Country: Analyses of Public and Private Expenditures in Chile. Journal of global oncology, 5, 1-17. https://doi.org/10.1200/JGO.19.00223

2018

Scholarly publications

Leopold, C., Peppercorn, J. M., Zafar, S. Y., & Wagner, A. K. (2018). Defining Value of Cancer Therapeutics-A Health System Perspective. Journal of the National Cancer Institute, 110(7), 699-703. https://doi.org/10.1093/jnci/djy079
Leopold, C., Wagner, A. K., Zhang, F., Lu, C. Y., Earle, C. C., Nekhlyudov, L., Ross-Degnan, D., & Wharam, J. F. (2018). Total and out-of-pocket expenditures among women with metastatic breast cancer in low-deductible versus high-deductible health plans. Breast Cancer Research and Treatment, 171(2), 449-459. https://doi.org/10.1007/s10549-018-4819-6
Morgan, S. G., Good, C. B., Leopold, C., Kaltenboeck, A., Bach, P. B., & Wagner, A. (2018). An analysis of expenditures on primary care prescription drugs in the United States versus ten comparable countries. Health Policy, 122(9), 1012-1017. https://doi.org/10.1016/j.healthpol.2018.07.005

2017

Scholarly publications

Leopold, C., Wagner, A. K., Zhang, F., Lu, C., Earle, C. C., Nekhlyudov, L., Ross-Degnan, D., & Wharam, J. F. (2017). Burden of out-of-pocket spending among high-deductible health plan members with metastatic breast cancer. Journal of Clinical Oncology, 35(15 suppl.), Article 1029. https://doi.org/10.1200/JCO.2017.35.15_suppl.1029
Leopold, C., Morgan, S. G., & Wagner, A. K. (2017). A rapidly changing global medicines environment: How adaptable are funding decision-making systems? Health Policy, 121(6), 637-643. https://doi.org/10.1016/j.healthpol.2017.04.002
Leopold, C., Park, E. R., & Nekhlyudov, L. (2017). The Impact of the Affordable Care Act on Cancer Survivorship. Cancer journal (Sudbury, Mass.), 23(3), 181-189. https://doi.org/10.1097/PPO.0000000000000263
Morgan, S. G., Leopold, C., & Wagner, A. K. (2017). Drivers of expenditure on primary care prescription drugs in 10 high-income countries with universal health coverage. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 189(23), E794-E799. https://doi.org/10.1503/cmaj.161481

2016

Scholarly publications

Leopold, C., Zhang, F., Wagner, A. K., Lu, C., Earle, C. C., Ross-Degnan, D., & Wharam, J. F. (2016). Disparities in all-cause mortality among younger commercially insured women with metastatic breast cancer. Journal of Clinical Oncology, 34(15 suppl), Article 18069. https://doi.org/10.1200/JCO.2016.34.15_suppl.e18069
Habl, C., & Leopold, C. (2016). What Happens To Originator Medicines When (Generic) Followers Enter The Public Market. Value in Health, 19(7), A443-A444. https://doi.org/10.1016/j.jval.2016.09.564
Leopold, C., Chambers, J. D., & Wagner, A. K. (2016). Thirty Years of Media Coverage on High Drug Prices in the United States: A Never-Ending Story or a Time for Change? Value in Health, 19(1), 14-16. https://doi.org/10.1016/j.jval.2015.10.008
Leopold, C., Wagner, A. K., Zhang, F., Lu, C. Y., Earle, C., Nekhlyudov, L., Ross-Degnan, D., & Wharam, J. F. (2016). Racial disparities in all-cause mortality among younger commercially insured women with incident metastatic breast cancer. Breast Cancer Research and Treatment, 158(2), 333-340. https://doi.org/10.1007/s10549-016-3875-z
Leopold, C. (2016). Author's response to "letter to the editor: lower vitamin D status may explain racial disparities in all-cause mortality among younger commercially insured women with incident metastatic breast cancer". Breast Cancer Research and Treatment, 159(1), 175. https://doi.org/10.1007/s10549-016-3921-x
Leopold, C., Wagner, A. K., Zhang, F., Lu, C. Y., Earle, C., Nekhlyudov, L., Ross-Degnan, D., & Wharam, J. F. (2016). Erratum to: Racial disparities in all-cause mortality among younger commercially insured women with incident metastatic breast cancer. Breast Cancer Research and Treatment, 160(2), 385. https://doi.org/10.1007/s10549-016-3988-4

2014

Scholarly publications

Vogler, S., Leopold, C., Zimmermann, N., Habl, C., & de Joncheere, K. (2014). The Pharmaceutical Pricing and Reimbursement Information (PPRI) initiative-Experiences from engaging with pharmaceutical policy makers. Health Policy and Technology, 3(2), 139-148. https://doi.org/10.1016/j.hlpt.2014.01.001
Vogler, S., Leopold, C., Zuidberg, C., & Habl, C. (2014). Medicines discarded in household garbage: Analysis of a pharmaceutical waste sample in Vienna. Journal of Pharmaceutical Policy and Practice, 7, Article 6. https://doi.org/10.1186/2052-3211-7-6
Leopold, C., Zhang, F., Mantel-Teeuwisse, A. K., Vogler, S., Valkova, S., Ross-Degnan, D., & Wagner, A. K. (2014). Impact of pharmaceutical policy interventions on utilization of antipsychotic medicines in Finland and Portugal in times of economic recession: interrupted time series analyses. International Journal for Equity in Health, 13, Article 13:53. https://doi.org/10.1186/1475-9276-13-53
https://dspace.library.uu.nl/bitstream/handle/1874/303402/1475_9276_13_53.pdf?sequence=1
Leopold, C., Mantel-Teeuwisse, A. K., Vogler, S., Valkova, S., de Joncheere, K., Leufkens, H. G. M., Wagner, A. K., Ross-Degnan, D., & Laing, R. (2014). Effect of the economic recession on pharmaceutical policy and medicine sales in eight European countries. Bulletin of the World Health Organization, 92(9), 630-640D. https://doi.org/10.2471/BLT.13.129114
Leopold, C. (2014). Pharmaceutical policy analysis – A European perspective on pricing and reimbursement in challenging times. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Utrecht University.
https://dspace.library.uu.nl/bitstream/handle/1874/289099/leopold.pdf?sequence=1

2013

Scholarly publications

Sabine, V., Nina, Z., Christine, L., Claudia, H., & Jan, M. (2013). Discounts and rebates granted for medicines for hospital use in five European countries. Open Pharmacoeconomics and Health Economics Journal, 5(1), 1-25. https://doi.org/10.2174/1876824520130426001
Leopold, C., Mantel - Teeuwisse, A., Vogler, S., de Joncheere, K., Laing, R. O., & Leufkens, H. G. M. (2013). Is Europe still heading to a common price level for on-patent medicines? An exploratory study among 15 Western European countries. Health Policy, 112(3), 209-16. https://doi.org/10.1016/j.healthpol.2013.08.012
Leopold, C., Vogler, S., Habl, C., Mantel-Teeuwisse, A. K., & Espin, J. (2013). Personalised medicine as a challenge for public pricing and reimbursement authorities – A survey among 27 European countries on the example of trastuzumab. Health Policy, 113(3), 313-22.

2012

Scholarly publications

Leopold, C., Vogler, S., Mantel-Teeuwisse, A. K., de Joncheere, K., Leufkens, H. G. M., & Laing, R. (2012). Differences in external price referencing in Europe: a descriptive overview. Health Policy, 104(1), 50-60. https://doi.org/10.1016/j.healthpol.2011.09.008
Leopold, C., Mantel-Teeuwisse, A. K., Seyfang, L., Vogler, S., de Joncheere, K., Laing, R. O., & Leufkens, B. (2012). Impact of external price referencing on medicine prices - a price comparison among 14 European countries. Southern Med Review, 5(2), 34-41.

2011

Scholarly publications

Vogler, S., Zimmermann, N., Leopold, C., & de Joncheere, K. (2011). Pharmaceutical policies in European countries in response to the global financial crisis. Southern Med Review, 4(2), 22-32. https://doi.org/10.5655/smr.v4i2.1004

2007

Scholarly publications

Fröschl, B., Arts, D., & Leopold, C. (2007). Corticosteroid therapy in the treatment of pediatric patients with atopic dermatitis. GMS. Health technology assessment, 3, Article Doc09.