Publications
2024
Scholarly publications
Nottelet, B., Buwalda, S., van Nostrum, C. F., Zhao, X., Deng, C., Zhong, Z., Cheah, E., Svirskis, D., Trayford, C., van Rijt, S., Ménard-Moyon, C., Kumar, R., Kehr, N. S., de Barros, N. R., Khademhosseini, A., Kim, H.-J., & Vermonden, T. (2024). Roadmap on multifunctional materials for drug delivery. JPhys Materials, 7(1), 012502. Article 012502. https://doi.org/10.1088/2515-7639/ad05e8
2023
Scholarly publications
Zia, R., Poortinga, A. T., Nazir, A., Aburuz, S., & van Nostrum, C. F. (2023). Triple-Emulsion-Based Antibubbles: A Step Forward in Fabricating Novel Multi-Drug Delivery Systems. Pharmaceutics, 15(12), 1-14. Article 2757. https://doi.org/10.3390/pharmaceutics15122757
Atlas, N., Uzair, B., Movellan, J., Gracia, R., Dupin, D., Loinaz, I., van Nostrum, C. F., & Hays, J. P. (2023). In vitro activity of novel apramycin-dextran nanoparticles and free apramycin against selected Dutch and Pakistani Klebsiella pneumonia isolates. Heliyon, 9(12), 1-13. Article e22821. https://doi.org/10.1016/j.heliyon.2023.e22821
Neumann, M., di Marco, G., Iudin, D., Viola, M., van Nostrum, C. F., van Ravensteijn, B. G. P., & Vermonden, T. (2023). Stimuli-Responsive Hydrogels: The Dynamic Smart Biomaterials of Tomorrow. Macromolecules, 56(21), 8377-8392. https://doi.org/10.1021/acs.macromol.3c00967
Zia, R., Poortinga, A. T., Nazir, A., Ayyash, M., & van Nostrum, C. F. (2023). Preparation of acid-responsive antibubbles from CaCO3-based Pickering emulsions. Journal of Colloid and Interface Science, 652(Pt B), 2054-2065. https://doi.org/10.1016/j.jcis.2023.09.007
Liu, M., Lau, C. Y. J., Cabello, I. T., Garssen, J., Willemsen, L. E. M., Hennink, W. E., & van Nostrum, C. F. (2023). Live Cell Imaging by Förster Resonance Energy Transfer Fluorescence to Study Trafficking of PLGA Nanoparticles and the Release of a Loaded Peptide in Dendritic Cells. Pharmaceuticals (Basel, Switzerland), 16(6), Article 818. https://doi.org/10.3390/ph16060818
Rooimans, T., Damen, M., Markesteijn, C. M. A., Schuurmans, C. C. L., de Zoete, N. H. C., van Hasselt, P. M., Hennink, W. E., van Nostrum, C. F., Hermes, M., Besseling, R., & Vromans, H. (2023). Development of a compounded propofol nanoemulsion using multiple non-invasive process analytical technologies. International Journal of Pharmaceutics, 640, Article 122960. https://doi.org/10.1016/j.ijpharm.2023.122960
Liu, M., Thijssen, S., Hennink, W. E., Garssen, J., van Nostrum, C. F., & Willemsen, L. E. M. (2023). Oral pretreatment with β-lactoglobulin derived peptide and CpG co-encapsulated in PLGA nanoparticles prior to sensitizations attenuates cow's milk allergy development in mice. Frontiers in Immunology, 13, Article 1053107. https://doi.org/10.3389/fimmu.2022.1053107
2022
Scholarly publications
Marinelli, L., Ciulla, M., Ritsema, J. A. S., van Nostrum, C. F., Cacciatore, I., Dimmito, M. P., Palmerio, F., Orlando, G., Robuffo, I., Grande, R., Puca, V., & Di Stefano, A. (2022). Preparation, Characterization, and Biological Evaluation of a Hydrophilic Peptide Loaded on PEG-PLGA Nanoparticles. Pharmaceutics, 14(9), Article 1821. https://doi.org/10.3390/pharmaceutics14091821
van Nostrum, C. F., Lammers, T., & Hennink, W. E. (2022). Questionable micelle formation of the double hydrophilic block copolymer PEG-pHPMA. International Journal of Pharmaceutics, 626, 1-3. Article 122147. https://doi.org/10.1016/j.ijpharm.2022.122147
https://dspace.library.uu.nl/bitstream/handle/1874/423376/1_s2.0_S0378517322007013_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/423376/1_s2.0_S0378517322007013_main.pdf?sequence=1
Wang, Y., Fens, M. H., van Kronenburg, N. C. H., Shi, Y., Lammers, T., Heger, M., van Nostrum, C. F., & Hennink, W. E. (2022). Magnetic beads for the evaluation of drug release from biotinylated polymeric micelles in biological media. Journal of controlled release : official journal of the Controlled Release Society, 349, 954-962. https://doi.org/10.1016/j.jconrel.2022.07.044
Bagheri, M., van Nostrum, C. F., Kok, R. J., Storm, G., Hennink, W. E., & Heger, M. (2022). Utility of Intravenous Curcumin Nanodelivery Systems for Improving In Vivo Pharmacokinetics and Anticancer Pharmacodynamics. Molecular Pharmaceutics, 19(9), 3057–3074. https://doi.org/10.1021/acs.molpharmaceut.2c00455
Zia, R., Nazir, A., Poortinga, A. T., & van Nostrum, C. F. (2022). Advances in antibubble formation and potential applications. Advances in Colloid and Interface Science, 305, 1-12. Article 102688. https://doi.org/10.1016/j.cis.2022.102688
Nijen Twilhaar, M. K., Czentner, L., Bouma, R. G., Olesek, K., Grabowska, J., Wang, A. Z., Affandi, A. J., Belt, S. C., Kalay, H., van Nostrum, C. F., van Kooyk, Y., Storm, G., & den Haan, J. M. M. (2022). Incorporation of Toll-Like Receptor Ligands and Inflammasome Stimuli in GM3 Liposomes to Induce Dendritic Cell Maturation and T Cell Responses. Frontiers in Immunology, 13, 1-17. Article 842241. https://doi.org/10.3389/fimmu.2022.842241
Wang, Y., Thies-Weesie, D. M. E., Bosman, E. D. C., van Steenbergen, M. J., van den Dikkenberg, J., Shi, Y., Lammers, T., van Nostrum, C. F., & Hennink, W. E. (2022). Tuning the size of all-HPMA polymeric micelles fabricated by solvent extraction. Journal of controlled release : official journal of the Controlled Release Society, 343, 338-346. https://doi.org/10.1016/j.jconrel.2022.01.042
Liu, M., Thijssen, S., van Nostrum, C. F., Hennink, W. E., Garssen, J., & Willemsen, L. E. M. (2022). Inhibition of cow’s milk allergy development in mice by oral delivery of β-lactoglobulin-derived peptides loaded PLGA nanoparticles is associated with systemic whey-specific immune silencing. Clinical and Experimental Allergy, 52(1), 137-148. https://doi.org/10.1111/cea.13967
2021
Scholarly publications
Su, X., Ramírez-Escudero, M., Sun, F., van den Dikkenberg, J. B., van Steenbergen, M. J., Pieters, R. J., Janssen, B. J. C., van Hasselt, P. M., Hennink, W. E., & van Nostrum, C. F. (2021). Internalization and transport of PEGylated lipid-based mixed micelles across Caco-2 cells mediated by scavenger receptor B1. Pharmaceutics, 13(12), 1-22. Article 2022. https://doi.org/10.3390/pharmaceutics13122022
Mihajlovic, M., Fermin, L., Ito, K., Van Nostrum, C. F., & Vermonden, T. (2021). Hyaluronic acid-based supramolecular hydrogels for biomedical applications. Multifunctional Materials, 4(3), Article 032001. https://doi.org/10.1088/2399-7532/ac1c8a
Lipophilic Drug Delivery Despite Cholestasis Study Group (2021). Novel Orally Formulated Mixed Micelles Optimize Vitamin K Absorption Under Bile-Deficient Conditions. Gastroenterology, 161(3), 1056-1059.e5. https://doi.org/10.1053/j.gastro.2021.05.056
Driest, P. J., Jong, J. A. W., Smakman, R., Moret, M.-E., Verhaar, M. C., Hennink, W. E., Gerritsen, K. G. F., & van Nostrum, C. F. (2021). Correction to "Reactivity of (Vicinal) Carbonyl Compounds with Urea". ACS Omega, 6(31), 20719-20721. https://doi.org/10.1021/acsomega.1c03307
Geremia, I., A.W. Jong, J., van Nostrum, C. F., Hennink, W. E., G.F. Gerritsen, K., & Stamatialis, D. (2021). New mixed matrix membrane for the removal of urea from dialysate solution. Separation and Purification Technology, 277, 1-6. Article 119408. https://doi.org/10.1016/j.seppur.2021.119408
Twilhaar, M. K. N., Czentner, L., van Nostrum, C. F., Storm, G., & Den Haan, J. M. M. (2021). Mimicking pathogens to augment the potency of liposomal cancer vaccines. Pharmaceutics, 13(7), 1-20. Article 954. https://doi.org/10.3390/pharmaceutics13070954
Bagheri, M., Fens, M. H., Kleijn, T. G., Capomaccio, R. B., Mehn, D., Krawczyk, P. M., Scutigliani, E. M., Gurinov, A., Baldus, M., van Kronenburg, N. C. H., Kok, R. J., Heger, M., van Nostrum, C. F., & Hennink, W. E. (2021). In Vitro and In Vivo Studies on HPMA-Based Polymeric Micelles Loaded with Curcumin. Molecular Pharmaceutics, 18(3), 1247-1263. https://doi.org/10.1021/acs.molpharmaceut.0c01114
2020
Scholarly publications
Nijen Twilhaar, M. K., Czentner, L., Grabowska, J., Affandi, A. J., Lau, C. Y. J., Olesek, K., Kalay, H., Van Nostrum, C. F., Van Kooyk, Y., Storm, G., & Haan, J. M. M. D. (2020). Optimization of Liposomes for Antigen Targeting to Splenic CD169+ Macrophages. Pharmaceutics, 12(12), Article 1138. https://doi.org/10.3390/pharmaceutics12121138
Bresseleers, J., Bagheri, M., Lebleu, C., Lecommandoux, S., Sandre, O., Pijpers, I. A. B., Mason, A. F., Meeuwissen, S., van Nostrum, C. F., Hennink, W. E., & van Hest, J. C. M. (2020). Tuning size and morphology of mpeg-b-p(Hpma-bz) copolymer self-assemblies using microfluidics. Polymers, 12(11), Article 2572. https://doi.org/10.3390/polym12112572
Liu, Y., Fens, M. H. A. M., Capomaccio, R. B., Mehn, D., Scrivano, L., Kok, R. J., Oliveira, S., Hennink, W. E., & van Nostrum, C. F. (2020). Correlation between in vitro stability and pharmacokinetics of poly(ε-caprolactone)-based micelles loaded with a photosensitizer. Journal of controlled release : official journal of the Controlled Release Society, 328, 942-951. https://doi.org/10.1016/j.jconrel.2020.10.040
Wang, Y., van Steenbergen, M. J., Beztsinna, N., Shi, Y., Lammers, T., van Nostrum, C. F., & Hennink, W. E. (2020). Biotin-decorated all-HPMA polymeric micelles for paclitaxel delivery. Journal of controlled release : official journal of the Controlled Release Society, 328, 970-984. https://doi.org/10.1016/j.jconrel.2020.09.013
Liu, Y., Van Steenbergen, M. J., Zhong, Z., Oliveira, S., Hennink, W. E., & Van Nostrum, C. F. (2020). Dithiolane-Crosslinked Poly(ϵ-caprolactone)-Based Micelles: Impact of Monomer Sequence, Nature of Monomer, and Reducing Agent on the Dynamic Crosslinking Properties. Macromolecules, 53(16), 7009–7024. https://doi.org/10.1021/acs.macromol.0c01031
Martínez-Jothar, L., Barendrecht, A. D., de Graaff, A. M., Oliveira, S., van Nostrum, C. F., Schiffelers, R. M., Hennink, W. E., & Fens, M. H. A. M. (2020). Endothelial Cell Targeting by cRGD-Functionalized Polymeric Nanoparticles under Static and Flow Conditions. Nanomaterials (Basel, Switzerland), 10(7), 1-19. https://doi.org/10.3390/nano10071353
van der Weide, H., Cossío, U., Gracia, R., Te Welscher, Y. M., Ten Kate, M. T., van der Meijden, A., Marradi, M., Ritsema, J. A. S., Vermeulen-de Jongh, D. M. C., Storm, G., Goessens, W. H. F., Loinaz, I., van Nostrum, C. F., Llop, J., Hays, J. P., & Bakker-Woudenberg, I. A. J. M. (2020). Therapeutic efficacy of novel antimicrobial peptide AA139-nanomedicines in a multidrug-resistant Klebsiella pneumoniae pneumonia-septicemia model in rats. Antimicrobial Agents and Chemotherapy, 64(9). https://doi.org/10.1128/AAC.00517-20
https://dspace.library.uu.nl/bitstream/handle/1874/432707/van-der-weide-et-al-2020-therapeutic-efficacy-of-novel-antimicrobial-peptide-aa139-nanomedicines-in-a-multidrug.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/432707/van-der-weide-et-al-2020-therapeutic-efficacy-of-novel-antimicrobial-peptide-aa139-nanomedicines-in-a-multidrug.pdf?sequence=1
Sheybanifard, M., Beztsinna, N., Bagheri, M., Buhl, E. M., Bresseleers, J., Varela-Moreira, A., Shi, Y., van Nostrum, C. F., van der Pluijm, G., Storm, G., Hennink, W. E., Lammers, T., & Metselaar, J. M. (2020). Systematic evaluation of design features enables efficient selection of Π electron-stabilized polymeric micelles. International Journal of Pharmaceutics, 584, Article 119409. https://doi.org/10.1016/j.ijpharm.2020.119409
https://dspace.library.uu.nl/bitstream/handle/1874/397197/1_s2.0_S0378517320303938_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/397197/1_s2.0_S0378517320303938_main.pdf?sequence=1
Liu, Y., Fens, M. H. A. M., Lou, B., van Kronenburg, N. C. H., Maas-Bakker, R. F. M., Kok, R. J., Oliveira, S., Hennink, W. E., & van Nostrum, C. F. (2020). π-π-Stacked Poly(ε-caprolactone)-b-poly(ethylene glycol) Micelles Loaded with a Photosensitizer for Photodynamic Therapy. Pharmaceutics, 12(4), Article 338. https://doi.org/10.3390/pharmaceutics12040338
Jong, J. A. W., Guo, Y., Veenhoven, C., Moret, M.-E., van der Zwan, J., Lucini Paioni, A., Baldus, M., Scheiner, K. C., Dalebout, R., van Steenbergen, M. J., Verhaar, M. C., Smakman, R., Hennink, W. E., Gerritsen, K. G. F., & van Nostrum, C. F. (2020). Phenylglyoxaldehyde-Functionalized Polymeric Sorbents for Urea Removal from Aqueous Solutions. ACS Applied Polymer Materials, 2(2), 515-527. https://doi.org/10.1021/acsapm.9b00948
Liu, Y., Scrivano, L., Peterson, J. D., Fens, M. H. A. M., Beltrán Hernández, I., Mesquita, B., Sastre Torano, J., Hennink, W. E., van Nostrum, C. F., & Oliveira, S. (2020). EGFR targeted nanobody functionalized polymeric micelles loaded with mTHPC for selective photodynamic therapy. Molecular Pharmaceutics. https://doi.org/10.1021/acs.molpharmaceut.9b01280
Jong, J. A. W., Guo, Y., Hazenbrink, D., Douka, S., Verdijk, D., van der Zwan, J., Houben, K., Baldus, M., Scheiner, K. C., Dalebout, R., Verhaar, M. C., Smakman, R., Hennink, W. E., Gerritsen, K. G. F., & van Nostrum, C. F. (2020). A Ninhydrin-Type Urea Sorbent for the Development of a Wearable Artificial Kidney. Macromolecular Bioscience, Article 1900396. https://doi.org/10.1002/mabi.201900396
van Gelder, M. K., Jong, J. A. W., Folkertsma, L., Guo, Y., Blüchel, C., Verhaar, M. C., Odijk, M., Van Nostrum, C. F., Hennink, W. E., & Gerritsen, K. G. F. (2020). Urea removal strategies for dialysate regeneration in a wearable artificial kidney. Biomaterials, 234, Article 119735. https://doi.org/10.1016/j.biomaterials.2019.119735
Setaro, F., Wennink, J. W. H., Mäkinen, P. I., Holappa, L., Trohopoulos, P. N., Ylä-Herttuala, S., van Nostrum, C. F., de la Escosura, A., & Torres, T. (2020). Amphiphilic phthalocyanines in polymeric micelles: a supramolecular approach toward efficient third-generation photosensitizers. Journal of Materials Chemistry B, 8(2), 282-289. https://doi.org/10.1039/c9tb02014d
https://dspace.library.uu.nl/bitstream/handle/1874/428258/c9tb02014d.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/428258/c9tb02014d.pdf?sequence=1
Ritter, D., Knebel, J., Niehof, M., Loinaz, I., Marradi, M., Gracia, R., Te Welscher, Y., van Nostrum, C. F., Falciani, C., Pini, A., Strandh, M., & Hansen, T. (2020). In vitro inhalation cytotoxicity testing of therapeutic nanosystems for pulmonary infection. Toxicology in Vitro, 63, Article 104714. https://doi.org/10.1016/j.tiv.2019.104714
2019
Scholarly publications
Fliervoet, L. A. L., van Nostrum, C. F., Hennink, W. E., & Vermonden, T. (2019). Balancing hydrophobic and electrostatic interactions in thermosensitive polyplexes for nucleic acid delivery. Multifunctional Materials, 2(2), Article 024002. https://doi.org/10.1088/2399-7532/ab12ee
Kordalivand, N., Tondini, E., Lau, C. Y. J., Vermonden, T., Mastrobattista, E., Hennink, W. E., Ossendorp, F., & Nostrum, C. F. V. (2019). Cationic synthetic long peptides-loaded nanogels: An efficient therapeutic vaccine formulation for induction of T-cell responses. Journal of Controlled Release, 315, 114-125. https://doi.org/10.1016/j.jconrel.2019.10.048
Jong, J. A. W., Smakman, R., Moret, M.-E., Verhaar, M. C., Hennink, W. E., Gerritsen, K. G. F., & Van Nostrum, C. F. (2019). Reactivity of (Vicinal) Carbonyl Compounds with Urea. ACS Omega, 4(7), 11928-11937. https://doi.org/10.1021/acsomega.9b01177
Martinez Jothar, L., Beztsinna, N., van Nostrum, C. F., Hennink, W. E., & Oliveira, S. (2019). Selective Cytotoxicity to HER2 Positive Breast Cancer Cells by Saporin-Loaded Nanobody-Targeted Polymeric Nanoparticles in Combination With Photochemical Internalization. Molecular Pharmaceutics, 16(4), 1633-1647. https://doi.org/10.1021/acs.molpharmaceut.8b01318
Professional publications
Rooimans, T., Sun, F., Vromans, H., Hennink, W. E., Van Hasselt, P. M., & Van Nostrum, C. F. (2019). Verbeterde formuleringen voor vitamine K-profylaxe: Uitzicht op effectief oraal alternatief voor pasgeborenen met cholestase. Pharmaceutisch Weekblad, 154(21), 14-15. https://www.pw.nl/achtergrond/2019/verbeterde-formuleringen-voor-vitamine-k-profylaxe
2018
Scholarly publications
Ritsema, J. A. S., der Weide, H. V., Te Welscher, Y. M., Goessens, W. H., van Nostrum, C. F., Storm, G., Bakker-Woudenberg, I. A., & Hays, J. P. (2018). Antibiotic-nanomedicines: facing the challenge of effective treatment of antibiotic-resistant respiratory tract infections. Future Microbiology, 13(15), 1683–1692. https://doi.org/10.2217/fmb-2018-0194
https://dspace.library.uu.nl/bitstream/handle/1874/373659/fmb_2018_0194.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/373659/fmb_2018_0194.pdf?sequence=1
Bagheri, M., Bresseleers, J., Varela Moreira, A., Sandre, O., Meeuwissen, S. A., Schiffelers, R. M., Metselaar, J. M., van Nostrum, C. F., van Hest, J. C. M., & Hennink, W. E. (2018). The Effect of Formulation and Processing Parameters on the Size of mPEG-b-p(HPMA-Bz) Polymeric Micelles. Langmuir, 34(50), 15495–15506. https://doi.org/10.1021/acs.langmuir.8b03576
Sun, F., Adrian, M., Beztsinna, N., van den Dikkenberg, J. B., Maas-Bakker, R. F., van Hasselt, P. M., van Steenbergen, M. J., Su, X., Kapitein, L. C., Hennink, W. E., & van Nostrum, C. F. (2018). Influence of PEGylation of vitamin-K-loaded mixed micelles on the uptake by and transport through Caco-2 cells. Molecular Pharmaceutics, 15(9), 3786–3795. https://doi.org/10.1021/acs.molpharmaceut.8b00258
Sun, F., Ye, C., Thanki, K., Leng, D., van Hasselt, P. M., Hennink, W. E., & van Nostrum, C. F. (2018). Mixed micellar system stabilized with saponins for oral delivery of vitamin K. Colloids and Surfaces B: Biointerfaces, 170, 521-528. https://doi.org/10.1016/j.colsurfb.2018.06.049
https://dspace.library.uu.nl/bitstream/handle/1874/368284/1_s2.0_S092777651830420X_main_1_.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/368284/1_s2.0_S092777651830420X_main_1_.pdf?sequence=1
Jong, J. A. W., Moret, M. E., Verhaar, M. C., Hennink, W. E., Gerritsen, K. G. F., & Van Nostrum, C. F. (2018). Effect of substituents on the reactivity of ninhydrin with urea. ChemistrySelect, 3(4), 1224-1229. https://doi.org/10.1002/slct.201800040
https://dspace.library.uu.nl/bitstream/handle/1874/369765/Jong_et_al_2018_ChemistrySelect.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/369765/Jong_et_al_2018_ChemistrySelect.pdf?sequence=1
Martínez-Jothar, L., Doulkeridou, S., Schiffelers, R. M., Torano, J. S., Oliveira, S., van Nostrum, C. F., & Hennink, W. E. (2018). Insights into maleimide - thiol conjugation chemistry: conditions for efficient surface functionalization of nanoparticles for receptor targeting. Journal of Controlled Release, 282, 101-109. https://doi.org/10.1016/j.jconrel.2018.03.002
https://dspace.library.uu.nl/bitstream/handle/1874/376473/Insights.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/376473/Insights.pdf?sequence=1
Kordalivand, N., Li, D., Beztsinna, N., Sastre Torano, J., Mastrobattista, E., van Nostrum, C. F., Hennink, W. E., & Vermonden, T. (2018). Polyethyleneimine coated nanogels for the intracellular delivery of RNase A for cancer therapy. Chemical Engineering Journal, 340, 32-41. https://doi.org/10.1016/j.cej.2017.12.071
Ritsema, J. A. S., Herschberg, E. M. A., Borgos, S. E., Løvmo, C., Schmid-Fetzer, R., Te Welscher, Y. M., Storm, G., & van Nostrum, C. F. (2018). Relationship between polarities of antibiotic and polymer matrix on nanoparticle formulations based on aliphatic polyesters. International Journal of Pharmaceutics, 548(2), 730-739. https://doi.org/10.1016/j.ijpharm.2017.11.017
Kostadinova, A. I., Middelburg, J., Ciulla, M., Garssen, J., Hennink, W. E., Knippels, L. M. J., van Nostrum, C. F., & Willemsen, L. E. M. (2018). PLGA nanoparticles loaded with beta-lactoglobulin-derived peptides modulate mucosal immunity and may facilitate cow's milk allergy prevention. European Journal of Pharmacology, 818, 211-220. https://doi.org/10.1016/j.ejphar.2017.10.051
2017
Scholarly publications
Kostadinova, A. I., Middelburg, J., Ciulla, M., Garssen, J., Hennink, W. E., Knippels, L. M., Van Nostrum, C. F., & Willemsen, L. E. (2017). Short beta-lactoglobulin-derived peptides loaded in PLGA nanoparticles for the prevention of cow's milk allergy. Allergy: European Journal of Allergy and Clinical Immunology, 72, 140-141. https://doi.org/10.1111/all.13247
van Lith, S. A. M., van Duijnhoven, S. M. J., Navis, A. C., Leenders, W. P. J., Dolk, E., Wennink, J. W. H., Van Nostrum, C. F., & Van Hest, J. C. M. (2017). Legomedicine - A Versatile Chemo-Enzymatic Approach for the Preparation of Targeted Dual-Labeled Llama Antibody-Nanoparticle Conjugates. Bioconjugate Chemistry, 28(2), 539-548. https://doi.org/10.1021/acs.bioconjchem.6b00638
Wennink, J. W. H., Liu, Y., Mäkinen, P. I., Setaro, F., de la Escosura, A., Bourajjaj, M., Lappalainen, J. P., Holappa, L. P., van den Dikkenberg, J. B., al Fartousi, M., Trohopoulos, P. N., Ylä-Herttuala, S., Torres, T., Hennink, W. E., & van Nostrum, C. F. (2017). Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles: A possible treatment for cardiovascular diseases. European Journal of Pharmaceutical Sciences, 107, 112-125. https://doi.org/10.1016/j.ejps.2017.06.038
Li, D., Chen, Y., Mastrobattista, E., Van Nostrum, C. F., Hennink, W. E., & Vermonden, T. (2017). Reduction-sensitive polymer-shell-coated nanogels for intracellular delivery of antigens. ACS Biomaterials Science and Engineering, 3(1), 42-48. https://doi.org/10.1021/acsbiomaterials.6b00651
Li, D., van Nostrum, C. F., Mastrobattista, E., Vermonden, T., & Hennink, W. E. (2017). Nanogels for intracellular delivery of biotherapeutics. Journal of Controlled Release, 259, 16-28. https://doi.org/10.1016/j.jconrel.2016.12.020
2016
Scholarly publications
Chen, Y., van Steenbergen, M. J., Li, D., van den Dikkenberg, J., Lammers, T., van Nostrum, C. F., Metselaar, J. M., & Hennink, W. E. (2016). Polymeric Nanogels with Tailorable Degradation Behavior. Macromolecular Bioscience, 16(8), 1122-1137. https://doi.org/10.1002/mabi.201600031
https://dspace.library.uu.nl/bitstream/handle/1874/344546/Polymeric.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/344546/Polymeric.pdf?sequence=1
Chen, Y., van Steenbergen, M. J., Li, D., van den Dikkenberg, J., Lammers, T., van Nostrum, C. F., Metselaar, J. M., & Hennink, W. E. (2016). Macromol. Biosci. 8/2016. Macromolecular Bioscience, 16(8), 1097. https://doi.org/10.1002/mabi.201670029
https://dspace.library.uu.nl/bitstream/handle/1874/344545/Chen_et_al_2016_Macromolecular_Bioscience.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/344545/Chen_et_al_2016_Macromolecular_Bioscience.pdf?sequence=1
Sun, F., Jaspers, T. C. C., van Hasselt, P. M., Hennink, W. E., & van Nostrum, C. F. (2016). A Mixed Micelle Formulation for Oral Delivery of Vitamin K. Pharmaceutical Research, 33(9), 2168-2179. https://doi.org/10.1007/s11095-016-1954-9
Marinelli, L., Cacciatore, I., Fornasari, E., Gasbarri, C., Angelini, G., Marrazzo, A., Pandolfi, A., Mandatori, D., Shi, Y., Van Nostrum, C. F., Hennink, W. E., & Di Stefano, A. (2016). Preparation and characterization of polymeric micelles loaded with a potential anticancer prodrug. Journal of Drug Delivery Science and Technology, 35, 24-29. https://doi.org/10.1016/j.jddst.2016.06.006
https://dspace.library.uu.nl/bitstream/handle/1874/344543/Preparation.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/344543/Preparation.pdf?sequence=1
Span, K., Verhoef, J. J. F., Hunt, H., van Nostrum, C. F., Brinks, V., Schellekens, H., & Hennink, W. E. (2016). A novel oral iron-complex formulation: Encapsulation of hemin in polymeric micelles and its in vitro absorption. European Journal of Pharmaceutics and Biopharmaceutics, 108, 226-234. https://doi.org/10.1016/j.ejpb.2016.09.002
https://dspace.library.uu.nl/bitstream/handle/1874/346102/iron.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/346102/iron.pdf?sequence=1
Li, D., Sun, F., Bourajjaj, M., Chen, Y., Pieters, E. H., Chen, J., Van Den Dikkenberg, J. B., Lou, B., Camps, M. G. M., Ossendorp, F., Hennink, W. E., Vermonden, T., & Van Nostrum, C. F. (2016). Strong: In vivo antitumor responses induced by an antigen immobilized in nanogels via reducible bonds. Nanoscale, 8(47), 19592-19604. https://doi.org/10.1039/c6nr05583d
Ramazani, F., van Nostrum, C. F., Storm, G., Kiessling, F., Lammers, T., Hennink, W. E., & Kok, R. J. (2016). Locoregional cancer therapy using polymer-based drug depots. Drug Discovery Today, 21(4), 640-647. https://doi.org/10.1016/j.drudis.2016.02.014
https://dspace.library.uu.nl/bitstream/handle/1874/341759/locoregional.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/341759/locoregional.pdf?sequence=1
Shirangi, M., Najafi, M., Rijkers, D. T. S., Kok, R. J., Hennink, W. E., & van Nostrum, C. F. (2016). Inhibition of Octreotide Acylation Inside PLGA Microspheres by Derivatization of the Amines of the Peptide with a Self-Immolative Protecting Group. Bioconjugate Chemistry, 576-585. https://doi.org/10.1021/acs.bioconjchem.5b00598
Ramazani, F., Chen, W., van Nostrum, C. F., Storm, G., Kiessling, F., Lammers, T., Hennink, W. E., & Kok, R. J. (2016). Strategies for encapsulation of small hydrophilic and amphiphilic drugs in PLGA microspheres: State-of-the-art and challenges. International Journal of Pharmaceutics, 499(1-2), 358-367. https://doi.org/10.1016/j.ijpharm.2016.01.020
https://dspace.library.uu.nl/bitstream/handle/1874/428259/517316.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/428259/517316.pdf?sequence=1
Shirangi, M., Hennink, W. E., Somsen, G. W., & Van Nostrum, C. F. (2016). Acylation of arginine in goserelin-loaded PLGA microspheres. European Journal of Pharmaceutics and Biopharmaceutics, 99, 18-23. https://doi.org/10.1016/j.ejpb.2015.11.008
https://dspace.library.uu.nl/bitstream/handle/1874/329712/695_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/329712/695_main.pdf?sequence=1
2015
Scholarly publications
Shi, Y., Van Nostrum, C. F., & Hennink, W. E. (2015). Interfacially Hydrazone Cross-linked Thermosensitive Polymeric Micelles for Acid-Triggered Release of Paclitaxel. ACS Biomaterials Science and Engineering, 1(6), 393-404. https://doi.org/10.1021/acsbiomaterials.5b00006
https://dspace.library.uu.nl/bitstream/handle/1874/428251/acsbiomaterials.5b00006.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/428251/acsbiomaterials.5b00006.pdf?sequence=1
Van Nostrum, R., & Storm, G. (2015). Editorial to European workshop on particulate systems in nanomedicine (2014). International Journal of Pharmaceutics, 482(1-2), 1. https://doi.org/10.1016/j.ijpharm.2015.01.040
https://dspace.library.uu.nl/bitstream/handle/1874/330116/1_s2.0_S0378517315000642_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/330116/1_s2.0_S0378517315000642_main.pdf?sequence=1
Shirangi, M., Hennink, W. E., Somsen, G. W., & Van Nostrum, C. F. (2015). Identification and Assessment of Octreotide Acylation in Polyester Microspheres by LC-MS/MS. Pharmaceutical Research, 32(9), 3044-3054. Article 1685. https://doi.org/10.1007/s11095-015-1685-3
Ramazani, F., Hiemstra, C., Steendam, R., Kazazi-Hyseni, F., Van Nostrum, C. F., Storm, G., Kiessling, F., Lammers, T., Hennink, W. E., & Kok, R. J. (2015). Sunitinib microspheres based on [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers for ocular drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 95, 368-377. https://doi.org/10.1016/j.ejpb.2015.02.011
https://dspace.library.uu.nl/bitstream/handle/1874/329467/Sunitinib.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/329467/Sunitinib.pdf?sequence=1
Naksuriya, O., Shi, Y., Van Nostrum, C. F., Anuchapreeda, S., Hennink, W. E., & Okonogi, S. (2015). HPMA-based polymeric micelles for curcumin solubilization and inhibition of cancer cell growth. European Journal of Pharmaceutics and Biopharmaceutics, 94, 501-512. Article 11968. https://doi.org/10.1016/j.ejpb.2015.06.010
https://dspace.library.uu.nl/bitstream/handle/1874/322974/hpma_based.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/322974/hpma_based.pdf?sequence=1
Shi, Y., Kunjachan, S., Wu, Z., Gremse, F., Moeckel, D., Van Zandvoort, M., Kiessling, F., Storm, G., Van Nostrum, C. F., Hennink, W. E., & Lammers, T. (2015). Fluorophore labeling of core-crosslinked polymeric micelles for multimodal in vivo and ex vivo optical imaging. Nanomedicine (London), 10(7), 1111-1125. https://doi.org/10.2217/nnm.14.170
https://dspace.library.uu.nl/bitstream/handle/1874/428267/emss_64328.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/428267/emss_64328.pdf?sequence=1
Kazazi-Hyseni, F., Van Vuuren, S. H., Van Der Giezen, D. M., Pieters, E. H., Ramazani, F., Rodriguez, S., Veldhuis, G. J., Goldschmeding, R., Van Nostrum, C. F., Hennink, W. E., & Kok, R. J. (2015). Release and pharmacokinetics of near-infrared labeled albumin from monodisperse poly(D,L-lactic-co-hydroxymethyl glycolic acid) microspheres after subcapsular renal injection. Acta Biomaterialia, 22, 141-154. https://doi.org/10.1016/j.actbio.2015.04.030
https://dspace.library.uu.nl/bitstream/handle/1874/319241/albumin.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/319241/albumin.pdf?sequence=1
Li, D., Kordalivand, N., Fransen, M. F., Ossendorp, F., Raemdonck, K., Vermonden, T., Hennink, W. E., & Van Nostrum, C. F. (2015). Reduction-sensitive dextran nanogels aimed for intracellular delivery of antigens. Advanced Functional Materials, 25(20), 2993-3003. https://doi.org/10.1002/adfm.201500894
Shi, Y., Van Der Meel, R., Theek, B., Oude Blenke, E., Pieters, E. H. E., Fens, M. H. A. M., Ehling, J., Schiffelers, R. M., Storm, G., Van Nostrum, C. F., Lammers, T., & Hennink, W. E. (2015). Complete regression of xenograft tumors upon targeted delivery of paclitaxel via ∏ - ∏ stacking stabilized polymeric micelles. ACS Nano, 9(4), 3740-3752. https://doi.org/10.1021/acsnano.5b00929
https://dspace.library.uu.nl/bitstream/handle/1874/314667/29.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/314667/29.pdf?sequence=1
Shi, Y., Cardoso, R. M., Van Nostrum, C. F., & Hennink, W. E. (2015). Anthracene functionalized thermosensitive and UV-crosslinkable polymeric micelles. Polymer Chemistry, 6(11), 2048-2053. https://doi.org/10.1039/c4py01759e
Novo, L., Mastrobattista, E., Van Nostrum, C. F., Lammers, T., & Hennink, W. E. (2015). Decationized polyplexes for gene delivery. Expert Opinion on Drug Delivery, 12(4), 507-512. https://doi.org/10.1517/17425247.2015.988136
https://dspace.library.uu.nl/bitstream/handle/1874/318813/2015.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/318813/2015.pdf?sequence=1
Ramazani, F., Chen, W., Van Nostrum, C. F., Storm, G., Kiessling, F., Lammers, T., Hennink, W. E., & Kok, R. J. (2015). Formulation and characterization of microspheres loaded with imatinib for sustained delivery. International Journal of Pharmaceutics, 482(1-2), 123-130. https://doi.org/10.1016/j.ijpharm.2015.01.043
https://dspace.library.uu.nl/bitstream/handle/1874/314506/1_s2.0_S0378517315000678_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/314506/1_s2.0_S0378517315000678_main.pdf?sequence=1
Kazazi-Hyseni, F., Zandstra, J., Popa, E. R., Goldschmeding, R., Lathuile, A. A. R., Veldhuis, G. J., Van Nostrum, C. F., Hennink, W. E., & Kok, R. J. (2015). Biocompatibility of poly(d,l-lactic-co-hydroxymethyl glycolic acid) microspheres after subcutaneous and subcapsular renal injection. International Journal of Pharmaceutics, 482(1-2), 99-109. https://doi.org/10.1016/j.ijpharm.2014.12.014
https://dspace.library.uu.nl/bitstream/handle/1874/428250/1_s2.0_S0378517314009028_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/428250/1_s2.0_S0378517314009028_main.pdf?sequence=1
Novo, L., Takeda, K. M., Petteta, T., Dakwar, G. R., Van Den Dikkenberg, J. B., Remaut, K., Braeckmans, K., Van Nostrum, C. F., Mastrobattista, E., & Hennink, W. E. (2015). Targeted decationized polyplexes for siRNA delivery. Molecular Pharmaceutics, 12(1), 150-161. https://doi.org/10.1021/mp500499x
https://dspace.library.uu.nl/bitstream/handle/1874/309188/mp500499x_1.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/309188/mp500499x_1.pdf?sequence=1
Shirangi, M., Sastre Toraño, J., Sellergren, B., Hennink, W. E., Somsen, G. W., & Van Nostrum, C. F. (2015). Methyleneation of peptides by N, N, N, N -tetramethylethylenediamine (TEMED) under conditions used for free radical polymerization: A mechanistic study. Bioconjugate Chemistry, 26(1), 90-100. https://doi.org/10.1021/bc500445d
https://dspace.library.uu.nl/bitstream/handle/1874/308745/bc500445d.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/308745/bc500445d.pdf?sequence=1
2014
Scholarly publications
Khazaie, Y., Novo, L., van Gaal, E., Fassihi, A., Mirahmadi-Zareh, S. Z., Esfahani, M. H. N., van Nostrum, C. F., Hennink, W. E., & Dorkoosh, F. (2014). Poly[N-(2-aminoethyl)ethyleneimine] as a New Non-Viral Gene Delivery Carrier: The Effect of Two Protonatable Nitrogens in the Monomer Unit on Gene Delivery Efficiency. Journal of Pharmacy and Pharmaceutical Sciences, 17(4), 461-474. https://doi.org/10.18433/J3R015
Shi, Y., Elkhabaz, A., Yousef Yengej, F. A., van den Dikkenberg, J., Hennink, W. E., & van Nostrum, C. F. (2014). π-π Stacking Induced Enhanced Molecular Solubilization, Singlet Oxygen Production, and Retention of a Photosensitizer Loaded in Thermosensitive Polymeric Micelles. Advanced healthcare materials, 3(12), 2023-2031. https://doi.org/10.1002/adhm.201400455
Kazazi-Hyseni, F., Landin, M., Lathuile, A., Veldhuis, G. J., Rahimian, S., Hennink, W. E., Kok, R. J., & van Nostrum, C. F. (2014). Computer Modeling Assisted Design of Monodisperse PLGA Microspheres with Controlled Porosity Affords Zero Order Release of an Encapsulated Macromolecule for 3 Months. Pharmaceutical Research, 31(10), 2844-2856. https://doi.org/10.1007/s11095-014-1381-8
Samadi, N., van Steenbergen, M. J., van den Dikkenberg, J. B., Vermonden, T., van Nostrum, C. F., Amidi, M., & Hennink, W. E. (2014). Nanoparticles Based on a Hydrophilic Polyester with a Sheddable PEG Coating for Protein Delivery. Pharmaceutical Research, 31(10), 2593-2604. https://doi.org/10.1007/s11095-014-1355-x
Novo, L., Mastrobattista, E., Van Nostrum, C. F., & Hennink, W. E. (2014). Targeted decationized polyplexes for cell specific gene delivery. Bioconjugate Chemistry, 25(4), 802-812. https://doi.org/10.1021/bc500074a
Novo, L., Rizzo, L. Y., Golombek, S. K., Dakwar, G. R., Lou, B., Remaut, K., Mastrobattista, E., Van Nostrum, C. F., Jahnen-Dechent, W., Kiessling, F., Braeckmans, K., Lammers, T., & Hennink, W. E. (2014). Decationized polyplexes as stable and safe carrier systems for improved biodistribution in systemic gene therapy. Journal of Controlled Release, 195, 162-175. https://doi.org/10.1016/j.jconrel.2014.08.028
2013
Scholarly publications
Samadi, N., Abbadessa, A., Di Stefano, A., Van Nostrum, C. F., Vermonden, T., Rahimian, S., Teunissen, E. A., Van Steenbergen, M. J., Amidi, M., & Hennink, W. E. (2013). The effect of lauryl capping group on protein release and degradation of poly(d,l-lactic-co-glycolic acid) particles. Journal of Controlled Release, 172(2), 436-443. https://doi.org/10.1016/j.jconrel.2013.05.034
Talelli, M., Oliveira, S., Rijcken, C., Pieters, E. H. E., Etrych, T., Ulbrich, K., van Nostrum, R. C. F., Storm, G., Hennink, W. E., & Lammers, T. (2013). Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy. Biomaterials, 34(4), 1255-60. https://doi.org/10.1016/j.biomaterials.2012.09.064
Shi, Y., van Steenbergen, M. J., Teunissen, E. A., Novo, L., Gradmann, S., Baldus, M., van Nostrum, C. F., & Hennink, W. E. (2013). Π−Π Stacking increases the stability and loading capacity of thermosensitive polymeric micelles for chemotherapeutic drugs. Biomacromolecules, 14(6), 1826-1837. https://doi.org/10.1021/bm400234c
Shi, Y., van den Dungen, E. T. A., Klumperman, B., van Nostrum, C. F., & Hennink, W. E. (2013). Reversible addition−fragmentation chain transfer synthesis of a micelle-forming, structure reversible thermosensitive diblock copolymer based on the N‑(2-hydroxy propyl)methacrylamide backbone. ACS Macro Letters, 2, 403-408.
Samadi, N., van Nostrum, C. F., Vermonden, T., Amidi, M., & Hennink, W. E. (2013). Mechanistic studies on the degradation and protein release characteristics of poly(lactic-co-glycolic-co-hydroxymethylglycolic acid) nanospheres. Biomacromolecules, 14(4), 1044-53.
Novo, L., van Gaal, E. V. B., Mastrobattista, E., van Nostrum, C. F., & Hennink, W. E. (2013). Decationized crosslinked polyplexes for redox-triggered gene delivery. Journal of Controlled Release, 169(3), 246-56.
2012
Scholarly publications
Seyednejad, H., Ji, W., Yang, F., Van Nostrum, C. F., Vermonden, T., Van Den Beucken, J. J. J. P., Dhert, W. J. A., Hennink, W. E., & Jansen, J. A. (2012). Coaxially electrospun scaffolds based on hydroxyl-functionalized poly(ε-caprolactone) and loaded with VEGF for tissue engineering applications. Biomacromolecules, 13(11), 3650-3660. https://doi.org/10.1021/bm301101r
Seyednejad, H., Gawlitta, D., Kuiper, R. V., de Bruin, A., van Nostrum, C. F., Vermonden, T., Dhert, W. J. A., & Hennink, W. E. (2012). In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly(ε-caprolactone). Biomaterials, 33(17), 4309-18. https://doi.org/10.1016/j.biomaterials.2012.03.002
Ghassemi, A. H., Van Steenbergen, M. J., Barendregt, A., Talsma, H., Kok, R. J., Van Nostrum, C. F., Crommelin, D. J. A., & Hennink, W. E. (2012). Controlled release of octreotide and assessment of peptide acylation from poly(D,L-lactide-co-hydroxymethyl glycolide) compared to PLGA microspheres. Pharmaceutical Research, 29(1), 110-120. https://doi.org/10.1007/s11095-011-0517-3
Seyednejad, H., Ji, W., Yang, F., van Nostrum, C. F., Vermonden, T., van den Beucken, J. J., Dhert, W. J. A., Hennink, W. E., & Jansen, J. A. (2012). Coaxially Electrospun Scaffolds Based on Hydroxyl-Functionalized Poly(epsilon-caprolactone) and Loaded with VEGF for Tissue Engineering Applications. Biomacromolecules, 13(11), 3650-3660.
de Graaf, A. J., Azevedo Próspero dos Santos, I. I., Pieters, E. H. E., Rijkers, D. T. S., van Nostrum, C. F., Vermonden, T., Kok, R. J., Hennink, W. E., & Mastrobattista, E. (2012). A micelle-shedding thermosensitive hydrogel as sustained release formulation. Journal of Controlled Release, 162, 582-590.
Crielaard, B. J., Rijcken, C. J. F., Quan, L., van der Wal, S., Altintas, I., van der Pot, M., Kruijtzer, J. A. W., Liskamp, R. M. J., Schiffelers, R. M., van Nostrum, C. F., Hennink, W. E., Wang, D., Lammers, T. G. G. M., & Storm, G. (2012). Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angewandte Chemie-International Edition, 29, 7254-7258. https://doi.org/10.1002/anie.201202713
Seyednejad, S. H., Gawlitta, D., Kuiper, R. V., de Bruin, A., van Nostrum, C. F., Vermonden, T., Dhert, W. J. A., & Hennink, W. E. (2012). In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly(epsilon-caprolactone). Biomaterials, 33(17), 4309-4318. http://www.ncbi.nlm.nih.gov/pubmed/22436798
de Graaf, A. J., Mastrobattista, E., Vermonden, T., van Nostrum, C. F., Rijkers, D. T. S., Liskamp, R. M. J., & Hennink, W. E. (2012). Thermosensitive peptide-hybrid ABC block copolymers obtained by ATRP: synthesis, self assembly, and enzymatic degradation. Macromolecules, 45, 842-851.
Other output
Rijcken, C. J. F., Kruijtzer, J. A. W., van Nostrum, C. F., van der Wal, S., Hennink, W. E., Liskamp, R. M. J., & Altintas, I. (2012). Tunable, biodegradable linker molecules for transient conjugation of components in drug delivery systems, and drug delivery systems prepared therewith. (Patent No. WO 2012039602 A1).
2011
Scholarly publications
De Graaf, A. J., Mastrobattista, E., Van Nostrum, C. F., Rijkers, D. T. S., Hennink, W. E., & Vermonden, T. (2011). ATRP, subsequent azide substitution and 'click' chemistry: Three reactions using one catalyst in one pot. Chemical Communications, 47(24), 6972-6974. https://doi.org/10.1039/c1cc12224j
Talelli, M., Rijcken, C. J. F., Santos Oliveira, S., van der Meel, R., van Bergen en Henegouwen, P. M. P., Lammers, T., van Nostrum, C. F., Storm, G., & Hennink, W. E. (2011). Reprint of "Nanobody--shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting". Journal of Controlled Release, 153(1), 93-102. https://doi.org/10.1016/j.jconrel.2011.06.003
D'Aurizio, E., van Nostrum, C. F., van Steenbergen, M. J., Sozio, P., Siepmann, F., Siepmann, J., Hennink, W. E., & Di Stefano, A. (2011). Preparation and characterization of poly(lactic-co-glycolic acid) microspheres loaded with a labile antiparkinson prodrug. International Journal of Pharmaceutics, 409(1-2), 289-96.
Seyednejad, S. H., Ghassemi, A. H., van Nostrum, C. F., Vermonden, T., & Hennink, W. E. (2011). Functional aliphatic polyesters for biomedical and pharmaceutical applications. Journal of Controlled Release, 152(1), 168-76.
Censi, R., van Putten, S., Vermonden, T., di Martino, P., van Nostrum, C. F., Harmsen, M. C., Bank, R. A., & Hennink, W. E. (2011). The tissue response to photopolymerized PEG-p(HPMAm-lactate)-based hydrogels. Journal of Biomedical Materials Research. Part A., 97(3), 219-29.
Censi, R., Schuurman, W., Malda, J., Di Dato, G., Burgisser, P., Dhert, W. J. A., van Nostrum, C. F., Vermonden, T., & Hennink, W. E. (2011). A Printable Photopolymerizable Thermosensitive p(HPMAm-lactate)-PEG Hydrogel for Tissue Engineering. Advanced Functional Materials, 10, 1833-1842.
de Graaf, A. J., Boere, K. W. M., Kemmink, J., Fokkink, R. G., van Nostrum, C. F., Rijkers, D. T. S., van de Gucht, J., Wienk, H. L. J., Baldus, M., Mastrobattista, E., Vermonden, T., & Hennink, W. E. (2011). Looped structure of flowerlike Micelles revealed by 1H NMR relaxometry and light scattering. Langmuir, 27(16), 9843-9848. https://doi.org/10.1021/la2019605
Talelli, M., Rijcken, J. F., Oliveira, S., Meel, R., van Bergen en Henegouwen, P. M. P., Lammers, T., van Nostrum, C. F., Storm, G., & Hennink, W. E. (2011). Nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting. Journal of Controlled Release, 151(2), 183-192.
Seyednejad, S. H., Gawlitta, D., Dhert, W. J. A., van Nostrum, C. F., Vermonden, T., & Hennink, W. E. (2011). Preparation and characterization of a three-dimensional printed scaffold based on a functionalized polyester for bone tissue engineering applications. Acta Biomaterialia, 7(5), 1999-2006. https://doi.org/10.1016/j.actbio.2011.01.018
Seyednejad, S. H., Ji, W., Schuurman, W., Dhert, W. J. A., Malda, J., Yang, F., Jansen, J. A., van Nostrum, C. F., Vermonden, T., & Hennink, W. E. (2011). An electrospun degradable scaffold based on a novel hydrophilic polyester for tissue-engineering applications. Macromolecular Bioscience, 11(12), 1684-1692. https://doi.org/10.1002/mabi.201100229
Verheyen, E., van der Wal, S., Deschout, H., Braeckmans, K., de Smedt, S., Barendregt, A., Hennink, W. E., & van Nostrum, C. F. (2011). Protein macromonomers containing reduction-sensitive linkers for covalent immobilization and glutathione triggered release from dextran hydrogels. Journal of Controlled Release, 156, 329-336. https://doi.org/10.1016/j.jconrel.2011.08.040
Verheyen, E., Schillemans, J. P., van Wijk, M., Demeniex, M. A., Hennink, W. E., & van Nostrum, C. F. (2011). Challenges for the effective molecular imprinting of proteins. Biomaterials, 32(11), 3008-20.
de Graaf, A. J., Mastrobattista, E., van Nostrum, C. F., Rijkers, D. T. S., Hennink, W. E., & Vermonden, T. (2011). ATRP, subsequent azide substitution and "click" chemistry: three reactions using one catalyst in a one-pot. Chemical Communications, 47, 6972-6974.
Schillemans, J. P., Verheyen, E., Barendregt, A., Hennink, W. E., & van Nostrum, C. F. (2011). Anionic and cationic dextran hydrogels for post-loading and release of proteins. Journal of Controlled Release, 150, 266-271. https://doi.org/10.1016/j.jconrel.2010.11.027
Talelli, M. A., Montari, K., Rijcken, C. J. F., Aben, R. W. M., Lammers, T. G. G. M., Scheeren, H. W., van Nostrum, C. F., Storm, G., & Hennink, W. E. (2011). Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry. Bioconjugate Chemistry, 22, 2519-2530.
van Nostrum, C. F. (2011). Covalently cross-linked amphiphilic block copolymer micelles. Soft Matter, 7, 3246-3259.
2010
Scholarly publications
Ghassemi, A. H., van Steenbergen, M. J., Talsma, H., van Nostrum, C. F., Jiskoot, W., Crommelin, D. J., & Hennink, W. E. (2010). Microspheres of hydrophilic PLGA highly attractive for protein delivery. Journal of controlled release : official journal of the Controlled Release Society, 148(1).
Schillemans, J. P., Hennink, W. E., & Van Nostrum, C. F. (2010). Charged dextran hydrogels for post-loading and release of proteins. Journal of Controlled Release, 148(1), 82-83. https://doi.org/10.1016/j.jconrel.2010.07.018
Talelli, M., Iman, M., Rijcken, C. J. F., Van Nostrum, C. F., & Hennink, W. E. (2010). Targeted core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin. Journal of Controlled Release, 148(1), 121-122. https://doi.org/10.1016/j.jconrel.2010.07.092
Ghassemi, A. H., Van Steenbergen, M. J., Talsma, H., Van Nostrum, C. F., Jiskoot, W., Crommelin, D. J. A., & Hennink, W. E. (2010). Microspheres of hydrophilic PLGA highly atractive for protein delivery. Journal of Controlled Release, 148(1), 39-40. https://doi.org/10.1016/j.jconrel.2010.07.047
Verheyen, E., Delain-Bioton, L., der Wal, S. V., El Morabit, N., Hennink, W. E., & van Nostrum, C. F. (2010). Protein macromonomers for covalent immobilization and subsequent triggered release from hydrogels. Journal of controlled release : official journal of the Controlled Release Society, 148(1).
Talelli, M., Rijcken, C. J. F., van Nostrum, C. F., Storm, G., & Hennink, W. E. (2010). Micelles based on HPMA copolymers. Advanced Drug Delivery Reviews, 62(2), 231-239. https://doi.org/10.1016/j.addr.2009.11.029
Censi, R., Vermonden, T., Deschout, H., Braeckmans, K., di Martino, P., de Smedt, S. C., van Nostrum, C. F., & Hennink, W. E. (2010). Photopolymerized thermosensitive poly(HPMAlactate)-PEG-based hydrogels: effect of network design on mechanical properties, degradation, and release behavior. Biomacromolecules, 11(8), 2143-51.
Schillemans, J. P., Hennink, W. E., & van Nostrum, C. F. (2010). The effect of network charge on the immobilization and release of proteins from chemically crosslinked dextran hydrogels. European Journal of Pharmaceutics and Biopharmaceutics, 76(3), 329-35.
Ghassemi, A. H., van Steenbergen, M. J., Talsma, H., van Nostrum, C. F., Crommelin, D. J. A., & Hennink, W. E. (2010). Hydrophilic polyester microspheres: effect of molecular weight and copolymer composition on release of BSA. Pharmaceutical Research, 27(9), 2008-17.
Talelli, M., Iman, M., Varkouhi, A. K., Rijcken, C. J. F., Schiffelers, R. M., Etrych, T., Ulbrich, K., van Nostrum, C. F., Lammers, T., Storm, G., & Hennink, W. E. (2010). Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin. Biomaterials, 31(30), 7797-804.
van Dijk, M., van Nostrum, C. F., Hennink, W. E., Rijkers, D. T. S., & Liskamp, R. M. J. (2010). Synthesis and characterization of enzymatically biodegradable PEG and peptide based hydrogels prepared by click chemistry. Biomacromolecules, 11, 1608-1614.
Verheyen, E., Delain-Bioton, L., van der Wal, S., el Morabit, N., Barendregt, A., Hennink, W. E., & van Nostrum, C. F. (2010). Conjugation of methacrylamide groups to a model protein via a reducible linker for immobilization and subsequent triggered release from hydrogels. Macromolecular Bioscience, 10(12), 1517-26.
Rijcken, C. J. F., Talelli, M. A., van Nostrum, C. F., Storm, G., & Hennink, W. E. (2010). Crosslinked micelles with transiently linked drugs – a versatile drug delivery system. European Journal of Nanomedicine, 3(1), 19-24. https://doi.org/10.1515/EJNM.2010.3.1.19
Ganea, G. M., Fakayode, S. O., Losso, J. N., van Nostrum, C. F., Sabliov, C. M., & Warner, I. M. (2010). Delivery of phytochemical thymoquinone using molecular micelle modified poly(D, L lactide-co-glycolide) (PLGA) nanoparticles. Nanotechnology, 21, 285104-285114.
van Dijk, M., Postma, T. M., Rijkers, D. T. S., Liskamp, R. M. J., van Nostrum, C. F., & Hennink, W. E. (2010). Synthesis and characterization of tailorable biodegradable thermoresponsive methacryloylamide polymers based on L-serine and L-threonine alkyl esters. Polymer, 51, 2478-2485.
Other output
Liskamp, R. M. J., Yim, C. B., Merkx, N. S. M., Elgersma, R. C., van Dijk, M., Brouwer, A. J., Boerman, O., van Nostrum, C. F., Hennink, W. E., Pieters, R. J., Kruijtzer, J. A. W., & Rijkers, D. T. S. (2010). Click chemistry in the synthesis of large peptide molecular constructs and peptide-based polymers. 27-28. Abstract from Unknown event.
2009
Scholarly publications
Elgersma, R. C., Van Dijk, M., Dechesne, A. C., Van Nostrum, C. F., Hennink, W. E., Rijkers, D. T. S., & Liskamp, R. M. J. (2009). Microwave-assisted click polymerization for the synthesis of Aβ(16-22) cyclic oligomers and their self-assembly into polymorphous aggregates. Organic and Biomolecular Chemistry, 7(21), 4517-4525. https://doi.org/10.1039/b912851d
Van Manakker, F. D., Braeckmans, K., Morabit, N. E., De Smedt, S. C., Van Nostrum, C. F., & Hennink, W. E. (2009). Protein-release behavior of self-assembled PEG-ß-cyclodextrin/PEG- cholesterol hydrogels. Advanced Functional Materials, 19(18), 2992-3001. https://doi.org/10.1002/adfm.200900603
Ghassemi, A. H., van Steenbergen, M. J., Talsma, H., van Nostrum, C. F., Jiskoot, W., Crommelin, D. J. A., & Hennink, W. E. (2009). Preparation and characterization of protein loaded microspheres based on a hydroxylated aliphatic polyester, poly(lactic-co-hydroxymethyl glycolic acid). Journal of Controlled Release, 138(1), 57-63. https://doi.org/10.1016/j.jconrel.2009.04.025
Talelli, M., Rijcken, C. J. F., Lammers, T., Seevinck, P. R., Storm, G., van Nostrum, C. F., & Hennink, W. E. (2009). Superparamagnetic Iron Oxide Nanoparticles Encapsulated in Biodegradable Thermosensitive Polymeric Micelles: Toward a Targeted Nanomedicine Suitable for Image-Guided Drug Delivery. Langmuir, 25(4), 2060-2067. http://www.ncbi.nlm.nih.gov/pubmed/19166276
Elgersma, R. C., van Dijk, M., Dechesne, A. C., van Nostrum, C. F., Hennink, W. E., Rijkers, D. T. S., & Liskamp, R. M. J. (2009). Microwave-assisted click polymerization for the synthesis of A beta(16-22) cyclic oligomers and their self-assembly into polymorphous aggregates. Organic & Biomolecular Chemistry, 7(21), 4517-4525.
Censi, R., Vermonden, T., van Steenbergen, M. J., Deschout, H., Braeckmans, K., de Smedt, S. C., van Nostrum, C. F., di Martino, P., & Hennink, W. E. (2009). Photopolymerized thermosensitive hydrogels for tailorable diffusion-controlled protein delivery. Journal of Controlled Release, 140(3), 230-6.
van de Manakker, F., Braeckmans, K., el Morabit, N., De Smedt, S. C., van Nostrum, C. F., & Hennink, W. E. (2009). Protein-Release Behavior of Self-Assembled PEG-beta-Cyclodextrin/PEG-Cholesterol Hydrogels. Advanced Functional Materials, 19(18), 2992-3001.
van de Manakker, F., Vermonden, T., van Nostrum, C. F., & Hennink, W. E. (2009). Cyclodextrin-based polymeric materials: synthesis, properties, and pharmaceutical/biomedical applications. Biomacromolecules, 10, 3157-3175.
Seyednejad, S. H., Vermonden, T., Fedorovich, N. E., van Eijk, R., van Steenbergen, M. J., Dhert, W. J. A., van Nostrum, C. F., & Hennink, W. E. (2009). Synthesis and characterization of hydroxyl-functionalized caprolactone copolymers and their effect on adhesion, proliferation, and differentiation of human mesenchymal stem cells. Biomacromolecules, 10(11), 3048-3054. https://doi.org/10.1021/bm900693p
Van De Manakker, F., Kroon-Batenburg, L. M. J., Vermonden, T., Van Nostrum, C. F., & Hennink, W. E. (2009). Supramolecular hydrogels formed by β-cyclodextrin self-association and host-guest inclusion complexes. Soft Matter, 6(1), 187-194. https://doi.org/10.1039/B916378F
van Dijk, M., Rijkers, D. T. S., Liskamp, R. M. J., van Nostrum, C. F., & Hennink, W. E. (2009). Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies. Bioconjugate Chemistry, 20, 2001-2016.
van Hasselt, P. M., Janssens, G. E., Slot, T. K., van der Ham, M., Minderhoud, T. C., Talelli, M., Akkermans, L. M. A., Rijcken, C. J., & van Nostrum, C. F. (2009). The influence of bile acids on the oral bioavailability of vitamin K encapsulated in polymeric micelles. Journal of Controlled Release, 133(2), 161-168.
Other output
Ghassemi, A. H., van Nostrum, C. F., & Hennink, W. E. (2009). System for controlled drug delivery comprising biodegradable polymer microparticles. (Patent No. 2002769).
2008
Scholarly publications
Van De Manakker, F., Vermonden, T., El Morabit, N., Van Nostrum, C. F., & Hennink, W. E. (2008). Rheological behavior of self-assembling PEG-β-cyclodextrin/ PEG-cholesterol hydrogels. Langmuir, 24(21), 12559-12567. https://doi.org/10.1021/la8023748
Hofman, J.-W., Carstens, M. G., Van Zeeland, F., Helwig, C., Flesch, F. M., Hennink, W. E., & Van Nostrum, C. F. (2008). Photocytotoxicity of mTHPC (temoporfin) loaded polymeric micelles mediated by lipase catalyzed degradation. Pharmaceutical Research, 25(9), 2065-2073. https://doi.org/10.1007/s11095-008-9590-7
Van De Manakker, F., Van Der Pot, M., Vermonden, T., Van Nostrum, C. F., & Hennink, W. E. (2008). Synthesis and characterization of self-assembling hydrogels based on beta-cyclodextrin/cholesterol inclusion complexes. In 8th World Biomaterials Congress 2008 (Vol. 3)
Vermonden, T., Fedorovich, N. E., Van Geemen, D., Alblas, J., Van Nostrum, C. F., Dhert, W. J. A., & Hennink, W. E. (2008). Degradation behavior and cytocompatibility of photopolymerized thermosensitive hydrogels. In 8th World Biomaterials Congress 2008 (Vol. 4)
Carstens, M. G., Van Nostrum, C. F., Verrijk, R., De Leede, L. G. J., Crommelin, D. J. A., & Hennink, W. E. (2008). A mechanistic study on the chemical and enzymatic degradation of PEG-Oligo(ε-caprolactone) micelles. Journal of Pharmaceutical Sciences, 97(1), 506-518. https://doi.org/10.1002/jps.21092
van Tomme, S. R., van Nostrum, C. F., Dijkstra, M., de Smedt, S. C., & Hennink, W. E. (2008). Effect of particle size and charge on the network properties of microsphere-based hydrogels. European Journal of Pharmaceutics and Biopharmaceutics, 70, 522-530.
https://dspace.library.uu.nl/bitstream/handle/1874/32611/http___www.sciencedirect.com_science__ob%3DMImg%26_imagekey%3DB6T6C-4SP3SN8-1-W%26_cdi%3D5027%26_user%3D457046%26_orig%3Dsearch%26_coverDate%3D10_31_2008%26_sk%3D999299997%26view%3Dc%26wchp%3DdGLbVzW-zSkWz%26md5%3D35c3523d82025517cbffc1de0a76c9dd%26ie%3D_sdarticle.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/32611/http___www.sciencedirect.com_science__ob%3DMImg%26_imagekey%3DB6T6C-4SP3SN8-1-W%26_cdi%3D5027%26_user%3D457046%26_orig%3Dsearch%26_coverDate%3D10_31_2008%26_sk%3D999299997%26view%3Dc%26wchp%3DdGLbVzW-zSkWz%26md5%3D35c3523d82025517cbffc1de0a76c9dd%26ie%3D_sdarticle.pdf?sequence=1
van de Manakker, F., Vermonden, T., el Morabit, N., van Nostrum, C. F., & Hennink, W. E. (2008). Rheological behavior of self-assembling PEG--cyclodextrin/PEG-cholesterol hydrogels. Langmuir, 24, 12559-12567.
van Dijk, M., Nollet, A., Weijers, P., Dechesne, A., van Nostrum, C. F., Hennink, W. E., Rijkers, D. T. S., & Liskamp, R. M. J. (2008). Synthesis and characterization of biodegradable peptide-based polymers prepared by microwave-assisted click chemistry. Biomacromolecules, 9, 2834-2843.
van Tomme, S. R., Mens, A., van Nostrum, C. F., & Hennink, W. E. (2008). Macroscopic hydrogels by self-assembly of oligolactate-grafted dextran microspheres. Biomacromolecules, 9, 158-165.
van de Manakker, F., van der Pot, M., Vermonden, T., van Nostrum, C. F., & Hennink, W. E. (2008). Self-assembling hydrogels based on -cyclodextrin/cholesterol inclusion complexes. Macromolecules, 41, 1766-1773.
Luten, J., van Nostrum, C. F., de Smedt, S. C., & Hennink, W. E. (2008). Biodegradable polymers as non-viral carriers for plasmid DNA delivery. Journal of Controlled Release, 126, 97-110.
Carstens, M. G., van Nostrum, C. F., Verrijk, R., de Leede, L., Crommelin, D. J. A., & Hennink, W. E. (2008). A mechanistic study on the chemical and enzymatic degradation of PEG-oligo(-caprolactone) micelles. Journal of Pharmaceutical Sciences, 97, 506-518.
Carstens, M. G., de Jong, P. H. J. L. F., van Nostrum, C. F., Kemmink, J., Verrijk, R., de Leede, L., Crommelin, D. J. A., & Hennink, W. E. (2008). The effect of core composition in biodegradable oligomeric micelles as taxane formulations. European Journal of Pharmaceutics and Biopharmaceutics, 68, 596-606.
Hofman, J. W., Carstens, M. G., van Zeeland, F., Helwig, C., Flesch, F. M., Hennink, W. E., & van Nostrum, C. F. (2008). Photocytotoxicity of mTHPC (temoporfin) loaded oligomeric micelles mediated by lipase catalyzed degradation. Pharmaceutical Research, 25, 2065-2073.
Vermonden, T., Fedorovich, N. E., van Geemen, D., Alblas, J., van Nostrum, C. F., Dhert, W. J. A., & Hennink, W. E. (2008). Photopolymerized thermosensitive hydrogels: synthesis, degradation, and cytocompatibility. Biomacromolecules, 9(3), 919-926.
Ramzi, A., Rijcken, C. J. F., Veldhuis, T. F. J., Schwan, D., Hennink, W. E., & van Nostrum, C. F. (2008). Core-shell structure of degradable, thermosensitive polymeric micelles studied by small-angle neutron scattering. Journal of Physical Chemistry. B, 112, 784-792.
Leemhuis, M., Akeroyd, N., Kruijtzer, J. A. W., van Nostrum, C. F., & Hennink, W. E. (2008). Synthesis and characterization of allyl functionalized poly-hydroxy)acids and their further dihydroxylation and epoxidation. European Polymer Journal, 44, 308-317.
Luten, J., van Steenbergen, M. J., Lok, M. C., de Graaff, A. M., van Nostrum, C. F., Talsma, H., & Hennink, W. E. (2008). Degradable PEG-folate coated poly(DMAEA-co-BA)phosphazene-based polyplexes exhibit receptor-specific gene expression. European Journal of Pharmaceutical Sciences, 33(3), 241-251.
Other output
van Dijk, M., van Nostrum, C. F., Hennink, W. E., Rijkers, D. T. S., & Liskamp, R. M. J. (2008). Synthesis, characterization and enzymatic degradation of peptide-triazole based polymers prepared by microwave-assisted click chemistry. 78. Abstract from The 30th European Peptide Symposium.
Rijcken, C. J. F., van Nostrum, C. F., & Hennink, W. E. (2008). Method for the stepwise covalent entrapment of compounds in polymeric devices via a degradable linker for controlled release.
Carstens, M. G., van Nostrum, C. F., & Hennink, W. E. (2008). Biodegradable photosensitizer-loaded polymeric micelles.
2007
Scholarly publications
Leemhuis, M., Kruijtzer, J. A. W., van Nostrum, C. F., & Hennick, W. E. (2007). In vitro hydrolytic degradation of hydroxyl-functionalized poly(α-hydroxy acid)s. Biomacromolecules, 8(9), 2943-2949. https://doi.org/10.1021/bm700476h
Loontjens, C. A. M., Vermonden, T., Leemhuis, M., Van Steenbergen, M. J., Van Nostrum, C. F., & Hennink, W. E. (2007). Synthesis and characterization of random and triblock copolymers of ε-caprolactone and (benzylated)hydroxymethyl glycolide. Macromolecules, 40(20), 7208-7216. https://doi.org/10.1021/ma071165w
Rijcken, C. J. F., Snel, C. J., Schiffelers, R. M., van Nostrum, C. F., & Hennink, W. E. (2007). Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies. Biomaterials, 28, 5581-5593.
Leemhuis, M., Kruijtzer, J. A. W., van Nostrum, C. F., & Hennink, W. E. (2007). In vitro hydrolytic degradation of hydroxyl-functionalized poly(alpha-hydroxy acid)s. Biomacromolecules, 8, 2943-2949.
Rijcken, C. J. F., Soga, S. O., Hennink, W. E., & van Nostrum, C. F. (2007). Triggered destabilisation of polymeric micelles and vesicles by changing polymers polarity: An attractive tool for drug delivery. Journal of Controlled Release, 120, 131-148.
Carstens, M. G., Bevernage, J. J. L., van Nostrum, C. F., van Steenbergen, M. J., Flesch, F. M., Verrijk, R., de Leede, L., Crommelin, D. J. A., & Hennink, W. E. (2007). Small oligomeric micelles based on end group modified mPeg-oligocaprolactone with monodisperse hydrophobic blocks. Macromolecules, 40, 116-122.
Loontjens, C. A. M., Vermonden, T., Leemhuis, M., van Steenbergen, M. J., van Nostrum, C. F., & Hennink, W. E. (2007). Synthesis and characterization of random and triblock copolymers of -caprolactone and (benzylated)hydroxymethyl glycolide. Macromolecules, 40, 7208-7216.
Rijcken, C. J. F., Hofman, J. W., van Zeeland, F., Hennink, W. E., & van Nostrum, C. F. (2007). Photosensitiser-loaded biodegradable polymeric micelles: Preparation, characterisation and in vitro PDT efficacy. Journal of Controlled Release, 124, 144-153.
van Dijk, M., Mustafa, K., Dechesne, A. C., van Nostrum, C. F., Hennink, W. E., Rijkers, D. T. S., & Liskamp, R. M. J. (2007). Synthesis of peptide-based polymers by microwave-assisted cycloaddition backbone polymerization. Biomacromolecules, 8, 327-330.
Hofman, J. W., van Zeeland, F., Turker, S., Talsma, H., Lambrechts, S. A. G., Hennink, W. E., van Nostrum, C. F., & Sakharov, D. (2007). Peripheral and axial substitution of phthalocyanines with solketal groups: synthesis and in vitro evaluation for photodynamic therapy. Journal of Medicinal Chemistry, 50, 1485-1494.
https://dspace.library.uu.nl/bitstream/handle/1874/26103/3.%2520Hofman%25202007%2C%2520pp1485-1494.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/26103/3.%2520Hofman%25202007%2C%2520pp1485-1494.pdf?sequence=1
2006
Scholarly publications
Rijcken, C. J., Leemhuis, M., Hofman, J. W., van Zeeland, F., Ramzi, A., van Nostrum, C. F., & Hennink, W. E. (2006). Methacrylamide-oligolactates as building blocks for targeted biodegradable polymeric micelles to deliver photosensitizers. Journal of controlled release : official journal of the Controlled Release Society, 116(2). https://doi.org/10.1016/j.jconrel.2006.09.023
Carstens, M. G., van Nostrum, C. F., Ramzi, A., de Leede, L. G., Crommelin, D. J., & Hennink, W. E. (2006). Self-assembly of PEG-oligolactates with monodisperse hydrophobic blocks. Journal of controlled release : official journal of the Controlled Release Society, 116(2). https://doi.org/10.1016/j.jconrel.2006.09.039
Jiang, X., van der Horst, A., van Steenbergen, M. J., Akeroyd, N., van Nostrum, C. F., Schoenmakers, P. J., & Hennink, W. E. (2006). Aqueous size-exclusion chromatography of cationic polymers for gene delivery. Journal of controlled release : official journal of the Controlled Release Society, 116(2). https://doi.org/10.1016/j.jconrel.2006.09.055
Schillemans, J. P., Flesch, F. M., Hennink, W. E., & Van Nostrum, C. F. (2006). Synthesis of bilayer-coated nanogels by selective cross-linking of monomers inside liposomes. Macromolecules, 39(17), 5885-5890. https://doi.org/10.1021/ma060727t
Schillemans, J. P., & van Nostrum, C. F. (2006). Molecularly imprinted polymer particles: synthetic receptors for future medicine. Nanomedicine (London), 1(4), 437-447. https://doi.org/10.2217/17435889.1.4.437
Leemhuis, M., van Nostrum, C. F., Kruijtzer, J. A. W., Zhong, Z. Y., ten Breteler, M. R., Dijkstra, P. J., Feijen, J., & Hennink, W. E. (2006). Functionalized poly(α-hydroxyacid)s via ring-opening polymerization: toward hydrophilic polyesters with pendant hydroxyl groups. Macromolecules, 39, 3500-3508.
Jiang, X., van der Horst, A., van Steenbergen, M. J., Akeroyd, N., van Nostrum, C. F., Schoenmakers, P. J., & Hennink, W. E. (2006). Molar-mass characterization of cationic polymers for gene delivery by aqueous size-exclusion chromatography. Pharmaceutical Research, 23, 595-603.
Schillemans, J. P., Flesch, F. M., Hennink, W. E., & van Nostrum, C. F. (2006). Synthesis of bilayer-coated nanogels by selective crosslinking of monomers inside liposomes. Macromolecules, 39, 5885-5890.
van Tomme, S. R., van Nostrum, C. F., de Smedt, S. C., & Hennink, W. E. (2006). Degradation behavior of dextran hydrogels composed of positively and negatively charged microspheres. Biomaterials, 27, 4141-4148.
Rijcken, C. J. F., Leemhuis, M., Veldhuis, T. F. J., Hennink, W. E., & van Nostrum, C. F. (2006). Step-by-step synthesis of monodisperse methacrylamidoalkyl oligolactates. Macromolecular Rapid Communications, 27, 1312-1316.
Professional publications
van Nostrum, C. F., Neradovic, D., Soga, S. O., & Hennink, W. E. (2006). Polymeric micelles with transient stability: a novel delivery concept. In S. Svenson (Ed.), Polymeric Drug Delivery I, Particulate Drug Carriers (pp. 40-54). (ACS Symposium Series; No. 923). American Chemical Society.
2005
Scholarly publications
Van Tomme, S. R., De Geest, B. G., Braeckmans, K., De Smedt, S. C., Siepmann, F., Siepmann, J., Van Nostrum, C. F., & Hennink, W. E. (2005). Mobility of model proteins in hydrogels composed of oppositely charged dextran microspheres studied by protein release and fluorescence recovery after photobleaching. Journal of Controlled Release, 110(1), 67-78. https://doi.org/10.1016/j.jconrel.2005.09.005
Soga, O., van Nostrum, C. F., & Hennink, W. E. (2005). Thermosensitive and biodegradable polymeric micelles with transient stability. Journal of controlled release : official journal of the Controlled Release Society, 101(1-3), 383-385.
Bos, G. W., Hennink, W. E., Brouwer, L. A., Den Otter, W., Veldhuis, T. F. J., Van Nostrum, C. F., & Van Luyn, M. J. A. (2005). Tissue reactions of in situ formed dextran hydrogels crosslinked by stereocomplex formation after subcutaneous implantation in rats. Biomaterials, 26(18), 3901-3909. https://doi.org/10.1016/j.biomaterials.2004.10.008
Kooijman, H., Leemhuis, M., van Nostrum, C. F., Hennink, W. E., & Spek, A. L. (2005). (3S,6R)-3-Benzyloxymethyl-6-methyl-1,4-dioxane-2,5-dione. Acta crystallographica. Section E, Structure reports, 61, o898-o900. https://doi.org/10.1107/S1600536805006902
Funhoff, A. M., van Nostrum, C. F., Lok, M. C., Kruijtzer, J. A. W., Crommelin, D. J. A., & Hennink, W. E. (2005). Cationic polymethacrylates with covalently linked membrane destabilizing peptides as gene delivery vectors. Journal of Controlled Release, 101(1-3), 233-246.
Rijcken, C. J. F., Veldhuis, T. F. J., Ramzi, A., Meeldijk, J. D., van Nostrum, C. F., & Hennink, W. E. (2005). Novel fast degradable thermosensitive polymeric micelles based on PEG-block-poly(N-(2-hydroxyethyl)methacrylamide-oligolactates). Biomacromolecules, 6(4), 2343-2351.
https://dspace.library.uu.nl/bitstream/handle/1874/11690/rijcken_04_bm0502720.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/11690/rijcken_04_bm0502720.pdf?sequence=2
Kooijman, H., Leemhuis, M., van Nostrum, C. F., Hennink, W. E., & Spek, A. L. (2005). (3S)-3-benzyloxymethyl-1,4-dioxane-2,5-dione. Acta crystallographica. Section E, Structure reports, 61, O3480-O3481. https://doi.org/10.1107/S1600536805030564
Soga, O., van Nostrum, C. F., Fens, M., Rijcken, C. J. F., Schiffelers, R. M., Storm, G., & Hennink, W. E. (2005). Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery. Journal of Controlled Release, 103(2), 341-353.
van Nostrum, C. F. (2005). Molecular imprinting: a new tool for drug innovation. Drug Discovery Today. Technologies, 2, 119-124.
https://dspace.library.uu.nl/bitstream/handle/1874/11685/nostrum_05_molecular_imprinting_119_124.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/11685/nostrum_05_molecular_imprinting_119_124.pdf?sequence=2
Van Thienen, T. G., Lucas, B., Flesch, F. M., van Nostrum, C. F., Demeester, J., & de Smedt, S. C. (2005). On the synthesis and characterization of biodegradable dextran nanogels with tunable degradation properties. Macromolecules, 38(20), 8503-8511.
Carstens, M. G., van Nostrum, C. F., Ramzi, A., Meeldijk, J. D., Verrijk, R., de Leede, L. L., Crommelin, D. J. A., & Hennink, W. E. (2005). Poly(ethylene glycol)-oligolactates with monodisperse hydrophobic blocks: Preparation, characterization, and behavior in water. Langmuir, 21(24), 11446-11454.
Funhoff, A. M., Monge, S., Teeuwen, R., Koning, G. A., Schuurmans-Nieuwenbroek, N. M. E., Crommelin, D. J. A., Haddleton, D. M., Hennink, W. E., & van Nostrum, C. F. (2005). PEG shielded polymeric double-layered micelles for gene delivery. Journal of Controlled Release, 102(3), 711-724.
Bos, G. W., Hennink, W. E., Brouwer, L. A., den Otter, W., Veldhuis, T. F. J., van Nostrum, C. F., & van Luyn, M. J. A. (2005). Biocompatibility of in situ formed dextran hydrogels crosslinked by stereocomplex formation after subcutaneous implantation in rats. Biomaterials, 26(18), 3901-3909.
van Tomme, S. R., van Steenbergen, M. J., de Smedt, S. C., van Nostrum, C. F., & Hennink, W. E. (2005). Self-gelling hydrogels based on oppositely charged dextran microspheres. Biomaterials, 26(14), 2129-2135.
https://dspace.library.uu.nl/bitstream/handle/1874/11899/tomme_05_selfgellinghydrogels.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/11899/tomme_05_selfgellinghydrogels.pdf?sequence=2
Kooijman, H., Leemhuis, M., van Nostrum, C. F., Hennink, W. E., & Spek, A. L. (2005). (3S,6S)-3-Benzyloxymethyl-6-methyl-1,4-dioxane-2,5-dione. Acta crystallographica. Section E, Structure reports, 61, O901-O903. https://doi.org/10.1107/S1600536805006914
van Tomme, S. R., de Geest, B. G., Braeckmans, K., de Smedt, S. C., Siepmann, F., Siepmann, J., van Nostrum, C. F., & Hennink, W. E. (2005). Mobility of model proteins in hydrogels composed of oppositely charged dextran microsphers studied by protein release and fluorescence recovery after photobleaching. Journal of Controlled Release, 110, 275-287.
https://dspace.library.uu.nl/bitstream/handle/1874/11898/tomme_05_mobilityofmodelproteins.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/11898/tomme_05_mobilityofmodelproteins.pdf?sequence=2
Professional publications
Hennink, W. E., van Nostrum, C. F., Crommelin, D. J. A., & Bezemer, J. Z. (2005). Hydrogels for the controlled release of proteins. In G. S. Kwon (Ed.), Polymeric Drug Delivery Systems Taylor & Francis.
2004
Scholarly publications
Van Nostrum, C. F., Veldhuis, T. F. J., Bos, G. W., & Hennink, W. E. (2004). Hydrolytic degradation of oligo(lactic acid): A kinetic and mechanistic study. Polymer, 45(20), 6779-6787. https://doi.org/10.1016/j.polymer.2004.08.001
Soga, O., Van Nostrum, C. F., Ramzi, A., Visser, T., Soulimani, F., Frederik, P. M., Bomans, P. H. H., & Hennink, W. E. (2004). Physicochemical characterization of degradable thermosensitive polymeric micelles. Langmuir, 20(21), 9388-9395. https://doi.org/10.1021/la048354h
Hennink, W. E., Van Steenis, J. H., & Van Nostrum, C. F. (2004). Fast biodegradable polymers. In Reflexive Polymers and Hydrogels: Understanding and Designing Fast Responsive Polymeric Systems (pp. 401-423). CRC Press.
Van Nostrum, C. F., Veldhuis, T. F. J., Bos, G. W., & Hennink, W. E. (2004). Tuning the degradation rate of poly(2-hydroxypropyl methacrylamide)-graft-oligo(lactic acid) stereocomplex hydrogels. Macromolecules, 37(6), 2113-2118. https://doi.org/10.1021/ma035534+
Van Nostrum, C. F. (2004). Delivery of photosensitizers in photodynamic therapy. Advanced Drug Delivery Reviews, 56(1), 5-6. https://doi.org/10.1016/j.addr.2003.10.003
Neradovic, D., Soga, O., Van Nostrum, C. F., & Hennink, W. E. (2004). The effect of the processing and formulation parameters on the size of nanoparticles based on block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) with and without hydrolytically sensitive groups. Biomaterials, 25(12), 2409-2418. https://doi.org/10.1016/j.biomaterials.2003.09.024
van Nostrum, C. F., Veldhuis, T. F. J., Bos, G. W., & Hennink, W. E. (2004). Tuning the degradation rate of poly(2-hydroxypropyl methacrylamide)-graft-oligo(lactid acid) stereocomplex hydrogels. Macromolecules, 37, 2113-2188.
https://dspace.library.uu.nl/bitstream/handle/1874/11687/nostrum_tuning_the_degradation.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/11687/nostrum_tuning_the_degradation.pdf?sequence=2
van Nostrum, C. F., Veldhuis, T. F. J., Bos, G. W., & Hennink, W. E. (2004). Hydrolytic degradation of oligo(lactid acid): a kinetic and mechanistic study. Polymer, 45, 6779-6787.
https://dspace.library.uu.nl/bitstream/handle/1874/11684/nostrum_04_hydrolytic_degradation_polymer.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/11684/nostrum_04_hydrolytic_degradation_polymer.pdf?sequence=2
Soga, S. O., van Nostrum, C. F., & Hennink, W. E. (2004). Poly(N-(2-hydroxypropyl) methacrylamide mono/di lactate): a new class of biodegradable polymers with tuneable thermosensitivity. Biomacromolecules, 5, 818-821.
Soga, S. O., van Nostrum, C. F., Ramzi, A., Visser, T., Soulimani, F., Frederik, P. M., Bomans, P. H. H., & Hennink, W. E. (2004). Physicochemical characterization of thermosensitive and degradable polymeric micelles. Langmuir, 20, 9388-9395.
Hennink, W. E., van Steenis, J. H., & van Nostrum, C. F. (2004). Fast degradable polymers. In: Reflexive Polymers and Hydrogels. In N. Yui, R. J. Mrsny, & K. Park (Eds.), Understanding and designing fast responsive polymeric system (pp. 401-423). CRC Press.
Funhoff, A. M., van Nostrum, C. F., Koning, G. A., Schuurmans-Nieuwenbroek, N. M. E., Crommelin, D. J. A., & Hennink, W. E. (2004). Endosomal escape of polymeric gene delivery complexes is not always enhanced by polymers buffering at low pH. Biomacromolecules, 5, 32-39.
Bos, G. W., Jacobs, J. J. L., Koten, J. W., van Tomme, S. R., Veldhuis, T., van Nostrum, C. F., den Otter, W., & Hennink, W. E. (2004). In situ crosslinked biodegradable hydrogels loaded with IL-2 are effective tools for local IL-2 therapy. European Journal of Pharmaceutical Sciences, 21, 561-567.
Funhoff, A. M., van Nostrum, C. F., Lok, M. C., Fretz, M. M., Crommelin, D. J. A., & Hennink, W. E. (2004). Poly(3-guanidinopropyl methacrylate): a novel cationic polymer for gene delivery. Bioconjugate Chemistry, 15, 1212-1220.
Hennink, W. E., De Jong, S. J., Bos, G. W., Veldhuis, T. F. J., & Van Nostrum, C. F. (2004). Biodegradable dextran hydrogels crosslinked by stereocomplex formation for the controlled release of pharmaceutical proteins. International Journal of Pharmaceutics, 277(1-2), 99-104. https://doi.org/10.1016/j.ijpharm.2003.02.002
van Nostrum, C. F. (2004). Polymeric micelles to deliver photosensitizers for photodynamic therapy. Advanced Drug Delivery Reviews, 56, 9-16.
https://dspace.library.uu.nl/bitstream/handle/1874/11686/nostrum_polymeric_micelles.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/11686/nostrum_polymeric_micelles.pdf?sequence=2
Funhoff, A. M., van Nostrum, C. F., Janssen, A. P. C. A., Fens, M. H. A. M., Crommelin, D. J. A., & Hennink, W. E. (2004). Polymer side-chain degradation as a tool to control the destabilization of polyplexes. Pharmaceutical Research, 21, 170-176.
Professional publications
van Nostrum, C. F. (2004). Antilichamen van kunststof. Chemisch2Weekblad, 100, 14-15.
Other output
Hennink, W. E., van Nostrum, C. F., van Steenbergen, M. J., Soga, S. O., & Rijcken, C. J. F. (2004). Temperature sensitive polymers. (Patent No. 10/804,302).
2003
Scholarly publications
Neradovic, D., van Steenbergen, M. J., Vansteelant, L., Meijer, Y. J., van Nostrum, C. F., & Hennink, W. E. (2003). Degradation mechanism and kinetics of thermosensitive polyacrylamides containing lactic acid side chains. Macromolecules, 36, 7491-7498.
van Nostrum, C. F., de Jong, S. J., Kettenes-van den Bosch, J. J., & Hennink, W. E. (2003). Hydrogels by stereocomplex formation and their use as drug delivery matrices. In S. M. Dinh, & P. Liu (Eds.), Advances in controlled drug delivery: science, technology, and products (pp. 129-141). (A.C.S. Symposium Series; No. 846). Library of congres cataloging-in-publication data.
Luten, J., van Steenis, J. H., van Someren, R., Kemmink, J., Schuurmans-Nieuwenbroek, N. M. E., Koning, G. A., Crommelin, D. J. A., van Nostrum, C. F., & Hennink, W. E. (2003). Water-soluble biodegradable cationic polyphosphazenes for gene delivery. Journal of Controlled Release, 89, 483-497.
Leemhuis, M., van Steenis, J. H., van Uxem, M. J., van Nostrum, C. F., & Hennink, W. E. (2003). A versatile route to functionalized dilactones as monomers for the synthesis of poly(alpha-hydroxy) acids. European Journal of Organic Chemistry, 17, 3344-3349.
2002
Scholarly publications
Hennink, W. E., & Van Nostrum, C. F. (2002). Novel crosslinking methods to design hydrogels. Advanced Drug Delivery Reviews, 54(1), 13-36. https://doi.org/10.1016/S0169-409X(01)00240-X
de Jong, S. J., van Nostrum, C. F., Kroon-Batenburg, L. M. J., Kettenes-van den Bosch, J. J., & Hennink, W. E. (2002). Oligolactate-grafted dextran hydrogels: detection of stereocomplex crosslinks by X-ray diffraction. Journal of Applied Polymer Science, 86, 289-293.
https://dspace.library.uu.nl/bitstream/handle/1874/14969/Jong_p289-293_02.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/14969/Jong_p289-293_02.pdf?sequence=1
2001
Scholarly publications
De Jong, S. J., De Smedt, S. C., Demeester, J., Van Nostrum, C. F., Kettenes-van den Bosch, J. J., & Hennink, W. E. (2001). Biodegradable hydrogels based on stereocomplex formation between lactic acid oligomers grafted to dextran. Journal of Controlled Release, 72(1-3), 47-56. https://doi.org/10.1016/S0168-3659(01)00261-9
De Jong, S. J., van Eerdenbrugh, B., Van Nostrum, C. F., Kettenes-van den Bosch, J. J., & Hennink, W. E. (2001). Physically crosslinked dextran hydrogels by stereocomplex formation of lactic acid oligomers: Degradation and protein release behavior. Journal of Controlled Release, 71(3), 261-275. https://doi.org/10.1016/S0168-3659(01)00228-0
Neradovic, D., van Nostrum, C. F., & Hennink, W. E. (2001). Thermoresponsive polymeric micelles with controlled instability based on hydrolytically sensitive N-isopropylacrylamide copolymers. Macromolecules, 7589-7591.
de Jong, S. J., Ruiz-Arias, E., Rijkers, D. T. S., van Nostrum, C. F., Kettenes-van den Bosch, J. J., & Hennink, W. E. (2001). New insights into the hydrolytic degradation of poly(lactic acid): Participation of the alochol terminus. Polymer, 42, 2795-2802.
de Jong, S. J., Arias, E. R., Rijkers, D. T. S., van Nostrum, C. F., Kettenes-van den Bosch, J. J., & Hennink, W. E. (2001). New insights into the hydrolytic degradation of poly(lactic acid): participation of the alcohol terminus. Polymer, 42, 2795-2802.
de Jong, S. J., van Eerdenbrugh, B., van Nostrum, C. F., Kettenes-van den Bosch, J. J., & Hennink, W. E. (2001). Physically crosslinked dextran hydrogels by stereocomplex formation of lactic acid oligomers: degradation and protein release behaviour. Journal of Controlled Release, 71, 261-275.
Other output
Neradovic, D., Hinrichs, W. L. J., Kettenes-van den Bosch, J. J., van Nostrum, C. F., & Hennink, W. E. (2001). Poly(N-isopropylacrylamide) with hydrolyzable lactic acid ester side groups: a new type of thermosensitive polymer suitable for drug delivery purposes. Journal of Controlled Release, 72, 225-309.
2000
Scholarly publications
Hennink, W. E., Cadee, J. A., de Jong, S. J., Franssen, O., Stenekes, R. J. H., van Nostrum, C. F., Talsma, H., & van Dijk-Wolthuis, W. N. E. (2000). Biodegradable hydrogels for the controlled release of pharmaceutical applications. In K. D. Park, I. C. Kwon, N. Yui, S. Y. Jeong, & K. Park (Eds.), Biomaterials and drug delivery toward new millennium (pp. 131-147). Han Rim Won Publising.
Other output
de Jong, S. J., de Smedt, S. C., Demeester, J., van Nostrum, C. F., Kettenes-van den Bosch, J. J., & Hennink, W. E. (2000). Novel Hydrogels Based on Physical Interaction Between Lactic Acid Oligomers Grafted to Hydrophilic Polymers. 13-16. Abstract from Unknown event, Asilomar, USA.
Hennink, W. E., van Nostrum, C. F., & de Jong, S. J. (2000). Stereocomplex hydrogeld. (Patent No. WO 0048576 A1).
1994
Scholarly publications
van Nostrum, C. F., Benneker, F. B. G., Nolte, R. J. M., Veldman, N., Spek, A. L., & Schouten, AJ. J. (1994). Crystal Structure and Silver Ion Complexation of a Novel Porphyrazine Substituted with four Dithiacrown ether Rings. Recueil des Travaux Chimiques des Pays‐Bas, 113(2), 109-110. https://doi.org/10.1002/recl.19941130206
1993
Scholarly publications
van Nostrum, C. F., Nolte, R. J. M., Devillers, M. A. C., Oostergetel, G. T., Teerenstra, M. N., & Schouten, A. J. (1993). Slow Structural Rearrangement of a Side-Chain Phthalocyanine Methacrylate Polymer at the Air-Water Interface. Macromolecules, 26(13), 3306-3312. https://doi.org/10.1021/ma00065a010
Van Nostrum, C. F., Bosman, A. W., Gelinck, G. H., Picken, S. J., Schouten, P. G., Warman, J. M., Schouten, A. J., & Nolte, R. J. M. (1993). Evidence of a chiral superstructure in the discotic mesophase of an optically active phthalocyanine. Journal of the Chemical Society, Chemical Communications, (14), 1120-1122. https://doi.org/10.1039/C39930001120