prof. dr. C.C. (Casper) Hoogenraad
c.hoogenraad@uu.nl
Gegenereerd op 2017-11-20 10:45:48


Chair
Cell biology and Neurobiology
Endowed by Utrecht University
Date of appointment 01.01.2011
Inaugural lecture date 01.02.2012
Profile

Research focus

The primary goal of the lab is to understand how intracellular trafficking underlies neuronal development and synapse function. We particularly focus on the areas of microtubule cytoskeleton, synaptic cargo trafficking and synaptic plasticity. The research in the lab can roughly be divided in three themes:

  • Cytoskeleton dynamics during neurodevelopment and synaptic plasticity. 
  • Motor proteins and adaptors as regulators of synaptic transport. 
  • Neuropsychiatric disorders linked to intracellular transport.

Honours and Awards

  • Dutch Talent Fellowship (2002)
  • Human Frontiers Long-Term Fellowship (HFSP-LTF, 2003)            
  • VIDI grant from ZonMW (2004)                
  • European Young Investigators (EURYI) award (2005)
  • Human Frontiers Career Development Award (HFSP-CD, 2005)    
  • Elected member of the EMBO Young Investigator Program (YIP, 2009)
  • VICI grant from NWO-ALW (2011)
  • Elected Member of “The Young Academy" (DJA), which is part of the The Royal Netherlands Academy of Arts and Sciences (KNAW, 2011-2015)             
  • European Research Council (ERC) Consolidator grant (2013)
  • Member of FENS-Kavli Network of Excellence (2014)
  • Member of the European Molecular Biology Organization (EMBO) (2015)
  • Member of Young Academy of Europe (YAE) (2015)
  • 10th International Brain Research Organization (IBRO) / Kemali Prize (2016)

Key recent references

1) Kuijpers M, et al., (2016) Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment. Neuron 89(3):461-71

2) Kevenaar JT, et al., (2016). Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity. Current Biology 26(7):849-61.

3) Lipka J, et al., (2016). Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites. EMBO Journal 35(3):302-18. 

4) van Bergeijk P, et al., (2015) Optogenetic control of organelle transport and positioning. Nature 518(7537):111-4 

5) van Beuningen SFB, et al., (2015) TRIM46 controls neuronal polarity and axon specification by driving the formation of parallel microtubule arrays. Neuron, 88(6):1208-26

6) Yau KW et al., (2014) Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development Neuron 82(5):1058-73

7) Benoit RM et al., (2014) Structural basis for recognition of synaptic vesicleprotein 2C by botulinum neurotoxin A. Nature 505(7481):108-11

8) Geiger JC et al., (2014) The GRIP1/14-3-3 Pathway Coordinates Cargo Trafficking and Dendrite Development. Developmental Cell 28(4):381-93 

9) Jaarsma D, et al., (2014) A role for Bicaudal-D2 in radial cerebellar granule cell migration. Nature Communications 5:3411 

10) Jiang K, et al., (2014) Microtubule Minus-End Stabilization by Polymerization-Driven CAMSAP Deposition. Developmental Cell 28(3):295-309 

11) Schlager MA, et al., (2014) Bicaudal d family adaptor proteins control the velocity of Dynein-based movements. Cell Rep 8(5):1248-56.

12) van Spronsen M, et al., (2013) TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites Neuron 77(3):485-502

13) van der Vaart B, et al., (2013) CFEOM1-Associated Kinesin KIF21A Is a Cortical Microtubule Growth Inhibitor. Developmental Cell 27(2):145-60

14) Kapitein LC, et al., (2013) Myosin-V opposes microtubule-based cargo transport and drives directional motility on cortical actin. Current Biology 23(9):828-34 

15) Hellal F, et al., (2011) Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science 331(6019):928-31 

16) Stiess M, et al., (2010) Axon extension occurs independently of centrosomal microtubule nucleation. Science 327(5966):704-7

17) Kapitein LC, et al., (2010). Mixed microtubules steer dynein-driven cargo transport into dendrites. Current Biology 20(4):290-299

18) Jaworski J, et al., (2009) Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron 61(1), 85-100 

Involved in the following study programme(s)
Gegenereerd op 2017-11-20 10:45:49
Curriculum vitae

Casper Hoogenraad (Delft, January 31, 1973)

BSc Biochemistry, School for Applied Sciences, Rotterdam, The Netherlands, 1994

MSc Molecular Biology, Utrecht University, Utrecht, The Netherlands, 1996

PhD Cell Biology, Erasmus University, Rotterdam, The Netherlands, 2001

Postdoctoral Fellow in the laboratory of Prof. Dr. Morgan Sheng, Massachusetts Institute of Technology (MIT), USA, 2002-2005

Associate Professor, Department of Neuroscience, Erasmus MC, The Netherlands, 2005-2010

Full Professor and Chair of Cell Biology, Department of Biology at the Faculty of Science, Utrecht University, The Netherlands, 2011-present

 

Gegenereerd op 2017-11-20 10:45:49
All publications
  2017 - Scholarly publications
van Riel, Wilhelmina E, Rai, Ankit, Bianchi, Sarah, Katrukha, Eugene A, Liu, Qingyang, Heck, Albert Jr, Hoogenraad, Casper C, Steinmetz, Michel O, Kapitein, Lukas C & Akhmanova, Anna (2017). Kinesin-4 KIF21B is a potent microtubule pausing factor. eLife, 6 (30 p.).
Frese, Christian K, Mikhaylova, Marina, Stucchi, Riccardo, Gautier, Violette, Liu, Qingyang, Mohammed, Shabaz, Heck, Albert J R, Altelaar, A F Maarten & Hoogenraad, Casper C (07.02.2017). Quantitative Map of Proteome Dynamics during Neuronal Differentiation. Cell Reports, 18 (6), (pp. 1527-1542) (16 p.). Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved..
  2016 - Scholarly publications
Waaijers, Selma, Muñoz, Javier, Berends, Christian, Ramalho, João J, Goerdayal, Soenita S, Low, Teck Y, Zoumaro-Djayoon, Adja D, Hoffmann, Michael, Koorman, Thijs, Tas, Roderick P, Harterink, Martin, Seelk, Stefanie, Kerver - Stumpfova, J, Hoogenraad, Casper C, Bossinger, Olaf, Tursun, Baris, van den Heuvel, Sander, Heck, Albert J R & Boxem, Mike (09.08.2016). A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. BMC Biology, 14.
Hoogenraad, Casper C & Akhmanova, Anna (2016). Bicaudal D Family of Motor Adaptors - Linking Dynein Motility to Cargo Binding. Trends in Cell Biology, 26 (5), (pp. 327-40) (14 p.). Copyright © 2016 Elsevier Ltd. All rights reserved..
Fréal, Amélie, Fassier, Coralie, Le Bras, Barbara, Bullier, Erika, de Gois, Stéphanie, Hazan, Jamilé, Hoogenraad, Casper C. & Couraud, François (20.04.2016). Cooperative Interactions between 480 kDa Ankyrin-G and EB proteins assemble the axon initial segment. Journal of Neuroscience, 36 (16), (pp. 4421-4433) (13 p.).
Yau, Kah Wai, Schätzle, Philipp, Tortosa, Elena, Pagès, Stéphane, Holtmaat, Anthony, Kapitein, Lukas C & Hoogenraad, Casper (27.01.2016). Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation. Journal of Neuroscience, 36 (4), (pp. 1071-85) (15 p.). Copyright © 2016 the authors 0270-6474/16/361072-15$15.00/0..
van Coevorden-Hameete, Marleen H, Titulaer, Maarten J, Schreurs, Marco W J, de Graaff, Esther, Sillevis Smitt, Peter A E & Hoogenraad, Casper C (2016). Detection and Characterization of Autoantibodies to Neuronal Cell-Surface Antigens in the Central Nervous System. Frontiers in Molecular Neuroscience, 9.
Kuijpers, Marijn, van de Willige, Dieudonnée, Freal, Amélie, Chazeau, Anaël, Franker, Mariella A, Hofenk, Jasper, Rodrigues, Ricardo J Cordeiro, Kapitein, Lukas C, Akhmanova, Anna, Jaarsma, Dick & Hoogenraad, Casper C (03.02.2016). Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment. Neuron, 89 (3), (pp. 461-71) (11 p.). Copyright © 2016 Elsevier Inc. All rights reserved..
Derks, Nienke A V, Krugers, Harm J, Hoogenraad, Casper C, Joëls, Marian & Sarabdjitsingh, R Angela (2016). Effects of Early Life Stress on Synaptic Plasticity in the Developing Hippocampus of Male and Female Rats. PLoS One, 11 (10).
Josifova, Dragana J, Monroe, Glen R, Tessadori, Federico, de Graaff, Esther, van der Zwaag, Bert, Mehta, Sarju G, Harakalova, Magdalena, Duran, Karen J, Savelberg, Sanne M C, Nijman, Isaäc J, Jungbluth, Heinz, Hoogenraad, Casper C, Bakkers, Jeroen, Knoers, Nine V, Firth, Helen V, Beales, Philip L, van Haaften, Gijs, van Haelst, Mieke M & , (2016). Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity. Human Molecular Genetics, 25 (11), (pp. 2158-2167). © The Author 2016. Published by Oxford University Press All rights reserved. For permissions, please e-mail: journals.permissions@oup.com..
Padzik, Artur, Deshpande, Prasannakumar, Hollos, Patrik, Franker, Mariella, Rannikko, Emmy H, Cai, Dawen, Prus, Piotr, Mågård, Mats, Westerlund, Nina, Verhey, Kristen J, James, Peter, Hoogenraad, Casper C & Coffey, Eleanor T (2016). KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons. Frontiers in Cellular Neuroscience, 10.
Kevenaar, Josta T, Bianchi, Sarah, van Spronsen, Myrrhe, Olieric, Natacha, Lipka, Joanna, Frias, Cátia P, Mikhaylova, Marina, Harterink, Martin, Keijzer, Nanda, Wulf, Phebe S, Hilbert, Manuel, Kapitein, Lukas C, de Graaff, Esther, Akhmanova, Anna, Steinmetz, Michel O & Hoogenraad, Casper C (04.04.2016). Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity. Current Biology, 26 (7), (pp. 849-861) (13 p.). Copyright © 2016 Elsevier Ltd. All rights reserved..
Harterink, Martin, van Bergeijk, Petra, Allier, Calixte, de Haan, Bart, van den Heuvel, Sander, Hoogenraad, Casper C & Kapitein, Lukas C (22.02.2016). Light-controlled intracellular transport in Caenorhabditis elegans. Current Biology, 26 (4), (pp. R153-4). Copyright © 2016 Elsevier Ltd. All rights reserved..
Schätzle, Philipp, Kapitein, Lukas C & Hoogenraad, Casper C (2016). Live imaging of microtubule dynamics in organotypic hippocampal slice cultures. Methods in Cell Biology, 131, (pp. 107-26) (20 p.). Copyright © 2016 Elsevier Inc. All rights reserved..
Tortosa Binacua, E., Kapitein, L.C. & Hoogenraad, C.C. (2016). Microtubule Organization and Microtubule-Associated Proteins (MAPs). In Kazuo Emoto, Rachel Wong, Eric Huang & Casper Hoogenraad (Eds.), Dendrites - Development and Disease (pp. 31) (75 p.). Japan: Springer.
van de Willige, Dieudonnée, Hoogenraad, Casper C & Akhmanova, Anna (2016). Microtubule plus-end tracking proteins in neuronal development. Cellular and Molecular Life Sciences, 73 (10), (pp. 2053-77) (25 p.).
Lipka, Joanna, Kapitein, Lukas C, Jaworski, Jacek & Hoogenraad, Casper C (01.02.2016). Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites. EMBO Journal, 35 (3), (pp. 302-18) (17 p.). © 2016 The Authors..
Wu, Jingchao, de Heus, Cecilia, Liu, Qingyang, Bouchet, Benjamin P, Noordstra, Ivar, Jiang, Kai, Hua, Shasha, Martin, Maud, Yang, Chao, Grigoriev, Ilya, Katrukha, Eugene A, Altelaar, A F Maarten, Hoogenraad, Casper C, Qi, Robert Z, Klumperman, Judith & Akhmanova, Anna (17.09.2016). Molecular Pathway of Microtubule Organization at the Golgi Apparatus. Developmental Cell, 39 (1), (pp. 44–60). Copyright © 2016 Elsevier Inc. All rights reserved..
van Beuningen, Sam Fb & Hoogenraad, Casper C (2016). Neuronal polarity - remodeling microtubule organization. Current Opinion in Neurobiology, 39, (pp. 1-7) (7 p.). Copyright © 2016 Elsevier Ltd. All rights reserved..
van Bergeijk, Petra, Hoogenraad, Casper C & Kapitein, Lukas C (2016). Right Time, Right Place - Probing the Functions of Organelle Positioning. Trends in Cell Biology, 26 (2), (pp. 121-134). Copyright © 2015 Elsevier Ltd. All rights reserved..
Post, Harm, Penning, Renske, Fitzpatrick, Martin, Garrigues, L.B., Wu, W., Mac Gillavry, H.D., Hoogenraad, C.C., Heck, A.J.R. & Altelaar, A.F.M. (28.11.2016). Robust, Sensitive, and Automated Phosphopeptide Enrichment Optimized for Low Sample Amounts Applied to Primary Hippocampal Neurons. Journal of Proteome Research
van den Berg, Robert, Laman, Jon D, van Meurs, Marjan, Hintzen, Rogier Q & Hoogenraad, Casper C (2016). Rotarod motor performance and advanced spinal cord lesion image analysis refine assessment of neurodegeneration in experimental autoimmune encephalomyelitis. Journal of Neuroscience Methods, 262, (pp. 66-76) (11 p.). Copyright © 2016 Elsevier B.V. All rights reserved..
Chazeau, Anaël, Katrukha, Eugene A, Hoogenraad, Casper C & Kapitein, Lukas C (2016). Studying neuronal microtubule organization and microtubule-associated proteins using single molecule localization microscopy. Methods in Cell Biology, 131, (pp. 127-49) (23 p.). Copyright © 2016 Elsevier Inc. All rights reserved..
Franker, Mariella A, Esteves da Silva, Marta, Tas, Roderick P, Tortosa, Elena, Cao, Yujie, Frias, Cátia P, Janssen, Anne F J, Wulf, Phebe S, Kapitein, Lukas C & Hoogenraad, Casper C (11.07.2016). Three-Step Model for Polarized Sorting of KIF17 into Dendrites. Current Biology, 26 (13), (pp. 1705-12) (8 p.). Copyright © 2016 Elsevier Ltd. All rights reserved..
Ruane, Peter T, Gumy, Laura F, Bola, Becky, Anderson, Beverley, Wozniak, Marcin J, Hoogenraad, Casper C & Allan, Victoria J (2016). Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2. Scientific Reports, 6.
  2015 - Scholarly publications
Kapitein, Lukas C & Hoogenraad, Casper C (05.08.2015). Building the Neuronal Microtubule Cytoskeleton. Neuron, 87 (3), (pp. 492-506) (15 p.). Copyright © 2015 Elsevier Inc. All rights reserved..
Jaarsma, Dick & Hoogenraad, Casper C (19.11.2015). Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders. Frontiers in Neuroscience, 9 (9 p.).
Franssen, Elske H P, Zhao, Rong-Rong, Koseki, Hiroaki, Kanamarlapudi, Venkateswarlu, Hoogenraad, Casper C, Eva, Richard & Fawcett, James W (2015). Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS. Journal of Neuroscience, 35 (21), (pp. 8359-75) (17 p.). Copyright © 2015 Franssen, Zhao et al..
van Erp, Susan, van den Heuvel, Dianne M A, Fujita, Yuki, Robinson, Ross A, Hellemons, Anita J C G M, Adolfs, Youri, Van Battum, Eljo Y, Blokhuis, Anna M, Kuijpers, Marijn, Demmers, Jeroen A A, Hedman, Håkan, Hoogenraad, Casper C, Siebold, Christian, Yamashita, Toshihide & Pasterkamp, R Jeroen (07.12.2015). Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases. Developmental Cell, 35 (5), (pp. 537-552) (16 p.). Copyright © 2015 Elsevier Inc. All rights reserved..
Akhmanova, Anna & Hoogenraad, Casper C (16.02.2015). Microtubule minus-end-targeting proteins. Current Biology, 25 (4), (pp. R162-71).
van Bergeijk, Petra, Adrian, Max, Hoogenraad, Casper C & Kapitein, Lukas C (07.01.2015). Optogenetic control of organelle transport and positioning. Nature
van Coevorden-Hameete, Marleen H, de Graaff, Esther, Titulaer, Maarten J, Hulsenboom, Esther, Sabater, Lidia, Hoogenraad, Casper C & Sillevis Smitt, Peter A (24.09.2015). Plasticity-related gene 5 - A novel surface autoantigen in paraneoplastic cerebellar degeneration. Neurology: Neuroimmunology and NeuroInflammation, 2 (5) (5 p.).
Esteves da Silva, Marta, Adrian, Max, Schätzle, Philipp, Lipka, Joanna, Watanabe, Takuya, Cho, Sukhee, Futai, Kensuke, Wierenga, Corette J, Kapitein, Lukas C & Hoogenraad, Casper C (03.11.2015). Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture. Cell Reports, 13 (5), (pp. 933-943) (11 p.). Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved..
Mikhaylova, Marina, Cloin, Bas M C, Finan, Kieran, van den Berg, Robert, Teeuw, Jalmar, Kijanka, Marta M, Sokolowski, Mikolaj, Katrukha, Eugene A, Maidorn, Manuel, Opazo, Felipe, Moutel, Sandrine, Vantard, Marylin, Perez, Frank, van Bergen en Henegouwen, Paul M P, Hoogenraad, Casper C, Ewers, Helge & Kapitein, Lukas C (2015). Resolving bundled microtubules using anti-tubulin nanobodies. Nature Communications, 6 (7 p.).
Cloin, Bas, Hoogenraad, Casper, Mikhaylova, Marina & Kapitein, Lukas (2015). Single molecule localization microscopy to study neuronal microtubule organization. Immunocytochemistry and Related Techniques (pp. 389-408). Humana Press.
Kevenaar, Josta T & Hoogenraad, Casper C (2015). The axonal cytoskeleton - from organization to function. Frontiers in Molecular Neuroscience, 8.
Joëls, Marian, Hoogenraad, Casper C, Poirazi, Panayiota & Di Luca, Monica (2015). The Hitchhiker's Guide to a Neuroscience Career. Neuron, 86 (3), (pp. 613-6) (4 p.). Copyright © 2015 Elsevier Inc. All rights reserved..
MacGillavry, Harold D & Hoogenraad, Casper C (15.07.2015). The internal architecture of dendritic spines revealed by super-resolution imaging - What did we learn so far?. Experimental Cell Research, 335 (2), (pp. 180-6) (7 p.). Copyright © 2015 Elsevier Inc. All rights reserved..
van Beuningen, Sam F B, Will, Lena, Harterink, Martin, Chazeau, Anaël, van Battum, Eljo Y, Frias, Cátia P, Franker, Mariella A M, Katrukha, Eugene A, Stucchi, Riccardo, Vocking, Karin, Antunes, Ana T, Slenders, Lotte, Doulkeridou, Sofia, Sillevis Smitt, Peter, Altelaar, A F Maarten, Post, Jan A, Akhmanova, Anna, Pasterkamp, R Jeroen, Kapitein, Lukas C, de Graaff, Esther & Hoogenraad, Casper C (06.12.2015). TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays. Neuron, (pp. 1208-1226). Copyright © 2015 Elsevier Inc. All rights reserved..
  2014 - Scholarly publications
Jaarsma, Dick, van den Berg, Robert, Wulf, Phebe S, van Erp, Susan, Keijzer, Nanda, Schlager, Max A, de Graaff, Esther, De Zeeuw, Chris I, Pasterkamp, R Jeroen, Akhmanova, Anna & Hoogenraad, Casper C (2014). A role for Bicaudal-D2 in radial cerebellar granule cell migration. Nature Communications, 5, (pp. 3411).
Maeder, Celine I, Shen, K. & Hoogenraad, Casper (2014). Axon and dendritic trafficking. Current Opinion in Neurobiology, 27, (pp. 165-170).
Adrian, Max, Kusters, Remy, Wierenga, Corette J, Storm, Cornelis, Hoogenraad, Casper C & Kapitein, Lukas C (2014). Barriers in the brain - resolving dendritic spine morphology and compartmentalization. Frontiers in Neuroanatomy, 8, (pp. 142).
Schlager, M.A., Serra-Marquez, A., Grigoriev, Ilya, Gumy, Laura, Estevez da Silva, M., Wulf, Phebe, Akhmanova, Anna & Hoogenraad, Casper (11.09.2014). Bicaudal d family adaptor proteins control the velocity of Dynein-based movements. Cell Reports, 8 (5), (pp. 1248-1256).
van Dis, Vera, Kuijpers, Marijn, Haasdijk, Elize D, Teuling, Eva, Oakes, Scott A, Hoogenraad, Casper C & Jaarsma, Dick (2014). Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons. Acta neuropathologica communications, 2, (pp. 38).
Hessel, Ellen V S, de Wit, Marina, Wolterink-Donselaar, Inge G, Karst, Henk, de Graaff, Esther, van Lith, Hein A, de Bruijn, Ewart, de Sonnaville, Sophietje, Verbeek, Nienke E, Lindhout, Dick, de Kovel, Carolien G F, Koeleman, Bobby P C, van Kempen, Marjan, Brilstra, Eva, Cuppen, Edwin, Loos, Maarten, Spijker, Sabine S, Kan, Anne A, Baars, Susanne E, van Rijen, Peter C, Gosselaar, Peter H, Groot Koerkamp, Marian J A, Holstege, Frank C P, van Duijn, Cornelia, Vergeer, Jeanette, Moll, Henriette A, Taubøll, Erik, Heuser, Kjell, Ramakers, Geert M J, Pasterkamp, R Jeroen, van Nieuwenhuizen, Onno, Hoogenraad, Casper C, Kas, Martien J H & de Graan, Pierre N E (2014). Identification of Srp9 as a febrile seizure susceptibility gene. Annals of Clinical and Translational Neurology, 1 (4), (pp. 239-50) (12 p.).
Yau, Kah Wai, van Beuningen, Sam F B, Cunha-Ferreira, Inês, Cloin, Bas M C, van Battum, Eljo Y, Will, Lena, Schätzle, Philipp, Tas, Roderick P, van Krugten, Jaap, Katrukha, Eugene A, Jiang, Kai, Wulf, Phebe S, Mikhaylova, Marina, Harterink, Martin, Pasterkamp, R Jeroen, Akhmanova, Anna, Kapitein, Lukas C & Hoogenraad, Casper C (04.06.2014). Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development. Neuron, 82 (5), (pp. 1058-73) (16 p.). Copyright © 2014 Elsevier Inc. All rights reserved..
Jiang, Kai, Hua, Shasha, Mohan, Renu, Grigoriev, Ilya, Yau, Kah Wai, Liu, Qingyang, Katrukha, Eugene A, Altelaar, A F Maarten, Heck, Albert J R, Hoogenraad, Casper C & Akhmanova, Anna (10.02.2014). Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition. Developmental Cell, 28 (3), (pp. 295-309) (15 p.). Copyright © 2014 Elsevier Inc. All rights reserved..
van Coevorden - Hameete, Marleen, de Graaff, Esther, Titulaer, M.J, Hoogenraad, Casper & Sillevis Smitt, P.A. (2014). Molecular and celllar mechanisms underlying anti-neuronal antibody mediated disorders of the central nervous system. Autoimmunity Reviews, 13 (3), (pp. 299-312) (14 p.).
Hoogenraad, Casper & Wierenga, Corette (2014). Neurons, Overview. In M.J. Aminoff & R.B. Daroff (Eds.), Encyclopedia of the Neurological Sciences (pp. 456-458). Oxford: Academic Press.
Benoit, Roger M., Frey, Daniel, Hilbert, Manuel, Kevenaar, Josta T., Wieser, Mara M., Stirnimann, Christian U., McMillan, David, Ceska, Tom, Lebon, Florence, Jaussi, Rolf, Steinmetz, Michel O., Schertler, Gebhard F X, Hoogenraad, Casper C., Capitani, Guido & Kammerer, Richard A. (01.01.2014). Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A. Nature, 505 (7481), (pp. 108-111) (4 p.).
Schwenk, B.M., Lang, C.M., Hogl, S., Tahirovic, S., Orozco, D., Rentzsch, K., Lichtenthaler, S.F., Hoogenraad, Casper, Capell, A., Haass, C. & Edbauer, D. (2014). The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes. EMBO Journal, 33 (5), (pp. 450-467) (18 p.).
Geiger, J.C., Lipka, Joanna, Hoyer, S., Schlager, M.A., Wulf, Phebe, Weinges, S., Demmers, J. & Hoogenraad, Casper (2014). The GRIP1/14-3-3 pathway coordinates cargo trafficking and dendrite development. Developmental Cell, 28 (4), (pp. 381-393) (13 p.).
  2013 - Scholarly publications
van der Vaart, Babet, van Riel, Wilhelmina E, Doodhi, Harinath, Kevenaar, Josta T, Katrukha, Eugene A, Gumy, Laura, Bouchet, Benjamin P, Grigoriev, Ilya, Spangler, Samantha A, Yu, Ka Lou, Wulf, Phebe S, Wu, Jingchao, Lansbergen, Gideon, van Battum, Eljo Y, Pasterkamp, R Jeroen, Mimori-Kiyosue, Yuko, Demmers, Jeroen, Olieric, Natacha, Maly, Ivan V, Hoogenraad, Casper C & Akhmanova, Anna (2013). CFEOM1-Associated Kinesin KIF21A Is a Cortical Microtubule Growth Inhibitor. Developmental Cell, 27 (2), (pp. 145-160) (16 p.). Copyright © 2013 Elsevier Inc. All rights reserved..
Spangler, S.A., Schmitz, S.K., Kevenaar, J.T., de Graaff, E., de Wit, H, Demmers, J., Toonen, R.F.G. & Hoogenraad, C.C. (2013). Liprin-alpha2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission. Journal of Cell Biology, 201 (6), (pp. 915-928) (14 p.).
Kapitein, L.C., van Bergeijk, P.M., Lipka, J.E., Keijzer, N., Wulf, P.S., Katrukha, Y., Akhmanova, A.S. & Hoogenraad, C.C. (2013). Myosin-V opposes microtuble-based cargo transport and drives directional motility on cortical actin. Current Biology, 23 (9), (pp. 828-834) (7 p.).
Kapitein, Lukas C, van Bergeijk, Petra, Lipka, Joanna, Keijzer, Nanda, Wulf, Phebe S, Katrukha, Eugene A, Akhmanova, Anna & Hoogenraad, Casper C (2013). Myosin-V opposes microtubule-based cargo transport and drives directional motility on cortical actin. Current Biology, 23 (9), (pp. 828-34) (7 p.). Copyright © 2013 Elsevier Ltd. All rights reserved..
van Spronsen, Myrrhe, Mikhaylova, Marina, Lipka, Joanna, Schlager, Max A, van den Heuvel, Dave J, Kuijpers, Marijn, Wulf, Phebe S, Keijzer, Nanda, Demmers, Jeroen, Kapitein, Lukas C, Jaarsma, Dick, Gerritsen, Hans, Akhmanova, Anna & Hoogenraad, Casper C (06.02.2013). TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. Neuron, 77 (3), (pp. 485-502) (18 p.). Copyright © 2013 Elsevier Inc. All rights reserved..
  2012 - Scholarly publications
van der Vaart, B., Franker, M.A., Kuijpers, M., Hua, S., Bouchet, B.P.J., Jiang, Kai, Grigoriev, I.S., Hoogenraad, C.C. & Akhmanova, A.S. (2012). Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote axonal development. Journal of Neuroscience, 32 (42), (pp. 14722-14728) (7 p.).
  2011 - Scholarly publications
Yu, K.L., Keijzer, N., Hoogenraad, C.C. & Akhmanova, A.S. (2011). Isolation of novel +TIPs and their binding partners using affinity purification techniques. Methods in Molecular Biology (pp. 293-316) (24 p.).
Nakagawa, T. & Hoogenraad, C.C. (2011). Lentiviral transgenesis. Methods in Molecular Biology, 693, (pp. 117-142) (26 p.).
Wei, Z., Zheng, S., Spangler, S.A., Yu, C., Hoogenraad, C.C. & Zhang, M. (2011). Liprin-mediated large signaling complex organization revealed by the liprin-alpha/CASK and liprin-alpha/liprin-beta complex structures. Molecular Cell, 43 (4), (pp. 586-598) (13 p.).
Hellal, Farida, Hurtado, Andres, Ruschel, Jörg, Flynn, Kevin C, Laskowski, Claudia J, Umlauf, Martina, Kapitein, Lukas C, Strikis, Dinara, Lemmon, Vance, Bixby, John, Hoogenraad, Casper C & Bradke, Frank (18.02.2011). Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science, 331 (6019), (pp. 928-931) (4 p.).
Kapitein, Lukas C & Hoogenraad, Casper C (2011). Which way to go? Cytoskeletal organization and polarized transport in neurons. Molecular and Cellular Neurosciences, 46 (1), (pp. 9-20) (12 p.). Copyright © 2010 Elsevier Inc. All rights reserved..
  2010 - Scholarly publications
Stiess, Michael, Maghelli, Nicola, Kapitein, Lukas C, Gomis-Rüth, Susana, Wilsch-Bräuninger, Michaela, Hoogenraad, Casper C, Tolić-Nørrelykke, Iva M & Bradke, Frank (05.02.2010). Axon extension occurs independently of centrosomal microtubule nucleation. Science, 327 (5966), (pp. 704-7) (4 p.).
Kapitein, Lukas C, Schlager, Max A, Kuijpers, Marijn, Wulf, Phebe S, van Spronsen, Myrrhe, MacKintosh, Frederick C & Hoogenraad, Casper C (23.02.2010). Mixed microtubules steer dynein-driven cargo transport into dendrites. Current Biology, 20 (4), (pp. 290-9) (10 p.). Copyright 2010 Elsevier Ltd. All rights reserved..
  2009 - Scholarly publications
Jaworski, Jacek, Kapitein, Lukas C, Gouveia, Susana Montenegro, Dortland, Bjorn R, Wulf, Phebe S, Grigoriev, Ilya, Camera, Paola, Spangler, Samantha A, Di Stefano, Paola, Demmers, Jeroen, Krugers, Harm, Defilippi, Paola, Akhmanova, Anna & Hoogenraad, Casper C (15.01.2009). Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron, 61 (1), (pp. 85-100) (16 p.).
  2005 - Scholarly publications
Akhmanova, A.S., Mausset-Bonnefont, A.L., van Cappellen, W., Keijzer, N., Hoogenraad, C.C., Stepanova, T., Drabek, K., van Wees, J.D., Mommaas, M., Onderwater, J., van der Meulen, H., Tanenbaum, M.E., Medema, R.H., Hoogerbrugge, J.W., Vreeburg, J., Uringa, E.J., Grootegoed, J.A., Grosveld, F. & Galjart, N. (2005). The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis. Genes and Development, 19 (20), (pp. 2501-15) (15 p.).
  2001 - Scholarly publications
Akhmanova, A.S., Hoogenraad, C.C., Drabek, K., Stepanova, T., Dortland, B., Verkerk, T., Vermeulen, W., Burgering, B.M.T., de Zeeuw, C.I., Grosveld, F. & Galjart, N. (2001). CLASPs are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fribroblasts. Cell, 104, (pp. 923-935) (13 p.).
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The division of Cell Biology provides multidisciplinary education and research training in cell biology and neurobiology. We provide courses for Bachelor, Master and PhD students at different levels, including the core courses of the Cell Biology and Neurobiology.

We also offer a variety of internship opportunities. If you are interested in a research project in cell biology, biophysics or neurobiology, please contact one of the group leaders to make an appointment to get an introduction into the organisation of the group and the ongoing research.

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Additional functions and activities

Present

  • Member of the Dutch Foundation for Fundamental Research of Matter (FOM) advisory committee 'Physics of life processes' (2013-present)
  • Member of Scientific Advisory Board of Crossbeta Biosciences (2014-present)
  • Member of the NWO-ALW VIDI review committee (2015-present)
  • Associated Editor of 'Frontier in Molecular Neuroscience' (2015-present)
  • Member of the Editorial Board of 'Molecular Brain' (2011-present)

Past

  • Vice-chair of the Scientific Advisory Board of ‘The International Foundation for Alzheimer's Research (ISAO)’ (2010-2016)
  • Member of the KNAW Committee ‘Large-scale research facilities' (2014-2016)
  • Member of the French National Research Agency Scientific Evaluation Committee (2014)
  • Member of the evaluation Committee VIB Center for the Biology of Disease (2015)
  • Course director of the CAJAL Advanced Neuroscience Training Programme  “Neuronal Cell Biology - Cytoskeleton and Trafficking” in Bordeaux, France (2016)

 

Gegenereerd op 2017-11-20 10:45:49
Full name
prof. dr. C.C. Hoogenraad Contact details
Hugo R. Kruytgebouw

Padualaan 8
Room N501
3584 CH  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 4585
Fax +31 30 253 2837
Postal address
Postbus 80.053
3508 TB    UTRECHT
The Netherlands
Gegenereerd op 2017-11-20 10:45:49
Last updated 07.09.2016