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Prof. dr. B. (Ben) de Kruijff

 
Science
Chemistry
Chemistry
Hugo R. Kruytgebouw
Padualaan 8
Kamer N607
3584 CH Utrecht

Prof. dr. B. (Ben) de Kruijff

Chemistry
b.dekruijff@uu.nl
Profile Publications Ancillary activities Contact
Profile Publications Ancillary activities Contact

Publications

2014

Scholarly publications

Mohammadi, T., Sijbrandi, R., Lutters, M., Verheul, J., Martin, N. I., den Blaauwen, T., de Kruijff, B., & Breukink, E. (2014). Specificity of the transport of lipid II by FtsW in Escherichia coli. Journal of Biological Chemistry, 289(21), 14707-14718. https://doi.org/10.1074/jbc.M114.557371

2012

Scholarly publications

Te Welscher, Y. M., Van Leeuwen, M. R., De Kruijff, B., Dijksterhuis, J., & Breukink, E. (2012). Polyene antibiotic that inhibits membrane transport proteins. Proceedings of the National Academy of Sciences of the United States of America, 109(28), 11156-11159. https://doi.org/10.1073/pnas.1203375109

2011

Scholarly publications

Olrichs, N. K., Aarsman, M. E. G., Verheul, J., Arnusch, C. J., Martin, N. I., Hervé, M., Vollmer, W., de Kruijff, B., Breukink, E., & den Blaauwen, T. (2011). A Novel in vivo Cell-Wall Labeling Approach Sheds New Light on Peptidoglycan Synthesis in Escherichia coli. ChemBioChem, 12(7), 1124-1133. https://doi.org/10.1002/cbic.201000552
Mohammadi, T., Van Dam, V., Sijbrandi, R., Vernet, T., Zapun, A., Bouhss, A., Diepeveen-De Bruin, M., Nguyen-Distéche, M., De Kruijff, B., & Breukink, E. (2011). Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane. EMBO Journal, 30(8), 1425-1432. https://doi.org/10.1038/emboj.2011.61
Olrichs, N. K., Aarsman, M. E. G., Verheul, J., Arnusch, C. J., Martin, N. I., Herve, M., Vollmer, W., de Kruijff, B., Breukink, E. J., & den Blaauwen, T. A. (2011). A novel in vivo cell-wall labelling approach sheds new light on peptidoglycan synthesis in Escherichia coli. ChemBioChem, 12, 1124-1133.

2010

Scholarly publications

Markvoort, A. J., Pfleger, N., Staffhorst, R. W. H. M., Hilbers, P. A. J., van Santen, R. A., Killian, J. A., & de Kruijff, B. (2010). Self-reproduction of fatty acid vesicles: a combined experimental and simulation study. Biophysical Journal, 99(5), 1520-1528. https://doi.org/10.1016/j.bpj.2010.06.057
https://dspace.library.uu.nl/bitstream/handle/1874/196761/Self-reproduction-of-fatty-acid_2010_Biophysical-Journal.pdf?sequence=1
te Welscher, Y. M., Jones, L., van Leeuwen, M. R., Dijksterhuis, J., de Kruijff, B., Eitzen, G., & Breukink, E. J. (2010). Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol. Antimicrobial Agents and Chemotherapy, 54(6), 2618-2625. https://doi.org/10.1128/AAC.01794-09

2009

Scholarly publications

Rijken, P. J., Houtkooper, R. H., Akbari, H., Brouwers, J. F. H. M., Koorengevel, M. C., de Kruijff, B., Frentzen, M., Vaz, F. M., & de Kroon, A. I. P. M. (2009). Cardiolipin molecular species with shorter acyl chains accumulate in Saccharomyces cerevisiae mutants lacking the acyl coenzyme A-binding protein Acb1p: New insights into acyl chain remodeling of cardiolipin. Journal of Biological Chemistry, 284(40), 27609-27619.
Khemtémourian, L. P., Lahoz Casarramona, G., Suylen, D. P., Hackeng, T. M., Meeldijk, J. D., de Kruijff, B., Hoppener, J. W. M., & Killian, J. A. (2009). Impaired processing of human pro-islet amyloid polypeptide is not a causative factor for fibril formation or membrane damage in vitro. Biochemistry, 48(46), 10918-10925. http://www.doi.org/10.1021/bi901076d
Hamelers, I. H. L., Staffhorst, R. W. H. M., Voortman, J., de Kruijff, B., Reedijk, J., van Bergen en Henegouwen, P. M. P., & de Kroon, A. I. P. M. (2009). High cytotoxicity of cisplatin nanocapsules in ovarian carcinoma cells depends on uptake by caveolae-mediated endocytosis. Clinical Cancer Research, 15(4), 1259-1268.

2008

Scholarly publications

Kramer, N. E., Hasper, H. E., van den Bogaard, P. T. C., Morath, S., de Kruijff, B., Hartung, T., Smid, E. J., Breukink, E. J., Kok, J., & Kuipers, O. P. (2008). Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis. Microbiology, 154, 1755-1762.
https://dspace.library.uu.nl/bitstream/handle/1874/33262/10Kramer-%2520Increased.pdf?sequence=1
Kooijman, E. E., Slot, J., Montes, L-R., Alonso, A., Gericke, A., de Kruijff, B., Kumar, S., & Goñi, F. M. (2008). Membrane organization and ionization behavior of the minor but crucial lipid ceramide-1-phosphate. Biophysical Journal, 94, 4320-4330.
https://dspace.library.uu.nl/bitstream/handle/1874/33215/9Kooijman-Membrane%2520organization.pdf?sequence=1
te Welscher, Y. M., ten Napel, H. H., Masià Balagué, M., Souza, C. M., Riezman, H., de Kruijff, B., & Breukink, E. J. (2008). Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. Journal of Biological Chemistry, 283(10), 6393-6401.
Arnusch, C. J., Bonvin, A. M. J. J., Verel, A. M., Jansen, W. T. M., Liskamp, R. M. J., de Kruijff, B., Pieters, R. J., & Breukink, E. J. (2008). The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant enterococci. Biochemistry, 47(48), 12661-12663. https://doi.org/10.1021/bi801597b
de Kruijff, B., van Dam, V., & Breukink, E. J. (2008). Lipid II:a central component in bacterial cell wall synthesis and a target for antibiotics. Prostaglandins, Leukotrienes and Essential Fatty Acids, 79, 117-121.
https://dspace.library.uu.nl/bitstream/handle/1874/33263/11DeKruijff-Lipid%2520II.pdf?sequence=1
Engel, M. F. M., Khemtemourian, L. P., Kleijer, C. C., Meeldijk, J. D., Jacobs, J., Verkleij, A. J., de Kruijff, B., Killian, J. A., & Hoppener, J. W. M. (2008). Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane. Proceedings of the National Academy of Sciences of the United States of America, 105, 6033-6038.
https://dspace.library.uu.nl/bitstream/handle/1874/32223/4Engel-Membrane%2520damage.pdf?sequence=1
Gubbens, J., Slijper, M., de Kruijff, B., & de Kroon, A. I. P. M. (2008). Protein complexes in bacterial and yeast mitochondrial membranes differ in their sensitivity towards dissociation by SDS. Biochimica et Biophysica Acta, 1784(12), 2012-2018.
https://dspace.library.uu.nl/bitstream/handle/1874/32608/5Gubbens-Protein%2520complexes.pdf?sequence=1

2007

Scholarly publications

Arnusch, C. J., Branderhorst, H., De Kruijff, B., Liskamp, R. M. J., Breukink, E., & Pieters, R. J. (2007). Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides. Biochemistry, 46(46), 13437-13442. https://doi.org/10.1021/bi7015553
Raja, M. M., Spelbrink, R. E. J., de Kruijff, B., & Killian, J. A. (2007). Phosphatidic acid plays a special role in stabilizing and folding of the tetrameric potassium channel KcsA. FEBS Letters, 581, 5715-5722.
https://dspace.library.uu.nl/bitstream/handle/1874/26632/Raja-Phosphatidic%2520acid.pdf?sequence=1
Gubbens, J., Vader, P., Damen, J. M. A., O'Flaherty, M. C., Slijper, M., de Kruijff, B., & de Kroon, A. I. P. M. (2007). Probing the membrane interface-interacting proteome using photactivatable lipid cross-linkers. Journal of Proteome Research, 6, 1951-1962.
https://dspace.library.uu.nl/bitstream/handle/1874/26331/13_probing_gubbens.pdf?sequence=1
Arnusch, C. J., Branderhorst, H. M., de Kruijff, B., Liskamp, R. M. J., Breukink, E. J., & Pieters, R. J. (2007). Enhanced membrane pore information by multimeric/oligomeric antimicrobial peptides. Biochemistry, 46, 13437-13442.
https://dspace.library.uu.nl/bitstream/handle/1874/26122/Arnusch-Enhanced%2520membrane.pdf?sequence=1
van Dam, V., Sijbrandi, R., Kol, M. A., Swiezewska, E., de Kruijff, B., & Breukink, E. J. (2007). Transmembrane transport of peptidoglycan precursors across model and bacterial membranes. Molecular Microbiology, 64(4), 1105-1114.
https://dspace.library.uu.nl/bitstream/handle/1874/33049/3VanDam-Transmembrane%2520transport.pdf?sequence=1
Akitake, B., Spelbrink, R. E. J., Anishkin, A., Killian, J. A., de Kruijff, B., & Sukharev, S. (2007). 2,2,2-Trifluoroethanol changes the transition kinetics and subunit interactions in the small bacterial mechanosensitive channel MscS. Biophysical Journal, 92, 2771-2784.
https://dspace.library.uu.nl/bitstream/handle/1874/26598/Akitake-2%2C2%2C2-Trifluoroethanol.pdf?sequence=1
Kooijman, E. E., Tieleman, D. P., Testerink, C., Munnik, T., Rijkers, D. T. S., Burger, K. N. J., & de Kruijff, B. (2007). An electrostatic/hydrogen bond switch as the basis for the specific interaction of phosphatidic acid with proteins. Journal of Biological Chemistry, 282, 11356-11364.
https://dspace.library.uu.nl/bitstream/handle/1874/26118/Kooijman-An%2520electrostatic.pdf?sequence=1

2006

Scholarly publications

Ganchev, D. N., Hasper, H. E., Breukink, E., & De Kruijff, B. (2006). Size and orientation of the lipid II headgroup as revealed by AFM imaging. Biochemistry, 45(19), 6195-6202. https://doi.org/10.1021/bi051913e
Kerssen, D., Hambruch, E., Klaas, W., Platta, H. W., de Kruijff, B., Erdmann, R., Kunau, W-H., & Schliebs, W. (2006). Membrane association of the cycling peroxisome import receptor Pex5p. Journal of Biological Chemistry, 281, 27003-27015.
de Kruijff, B., Killian, J. A., Ganchev, D. N., Rinia, H. A., & Sparr, E. M. (2006). Striated domains: self-organizing ordered assemblies of transmembrane α-helical peptides and lipids in bilayers. Biological Chemistry, 387, 235-241.
https://dspace.library.uu.nl/bitstream/handle/1874/20000/DeKruijff-Striated%2520domains.pdf?sequence=1
Ganchev, D. N., Hasper, H. E., Breukink, E. J., & de Kruijff, B. (2006). Size and orientation of the Lipid II head group as revealed by AFM imaging. Biochemistry, 45, 6195-6202.
https://dspace.library.uu.nl/bitstream/handle/1874/19982/Ganchev-Size%2520and%2520orientation.pdf?sequence=1
Boumann, H. A., Gubbens, J., Koorengevel, M. C., Oh, C-S., Martin, C. E., Heck, A. J. R., Patton-Vogt, J., Henry, S. A., de Kruijff, B., & de Kroon, A. I. P. M. (2006). Depletion of phosphatidylcholine in yeast induces shortening and increased saturation of the lipid acyl chains: evidence for regulation of intrinsic membrane curvature in a eukaryote. Molecular Biology of the Cell, 17, 1006-1017.
https://dspace.library.uu.nl/bitstream/handle/1874/19761/Boumann-Depletion%2520of%2520phosphatidylcholine.pdf?sequence=1
de Kroon, A. I. P. M., Stafhorst, R. W. H. M., de Kruijff, B., & Burger, K. N. J. (2006). Nanocapsules: a new vehicle for intracellular delivery of drugs. In R. Harris (Ed.), Cell Biology Protocols (pp. 250-254). Wiley.
https://dspace.library.uu.nl/bitstream/handle/1874/19472/12%2520DeKroon-Nanocapsules.pdf?sequence=1
Breukink, E. J., & de Kruijff, B. (2006). Lipid II as a target for antibiotics. Nature Reviews. Drug Discovery, 5, 321-332.
https://dspace.library.uu.nl/bitstream/handle/1874/19999/Breukink-Lipid%2520II%2520as%2520a%2520target.pdf?sequence=1

Other output

Kooijman, E. E., Rijkers, D. T. S., Liskamp, R. M. J., Burger, K. N. J., & de Kruijff, B. (2006). Hydrogen bonding enhances the electrostatic attraction between phosphatidic acid and basic amino acid residues in proteins. Abstract from 231st ACS National Meeting, Atlanta, GA, United States.

2005

Scholarly publications

Spelbrink, R. E. J., Kolkman, A., Slijper, M., Killian, J. A., & de Kruijff, B. (2005). Detection and identification of stable oligomeric protein complexes in Escherichia coli inner membranes. Journal of Biological Chemistry, 280, 28742-28748.
https://dspace.library.uu.nl/bitstream/handle/1874/7773/Spelbrink-Detection%2520and%2520identification.pdf?sequence=2
Sparr, E. M., Ganchev, D. N., Snel, M. M. E., Ridder, A. N. J. A., Kroon-Batenburg, L. M. J., Chupin, V. V., Rijkers, D. T. S., Killian, J. A., & de Kruijff, B. (2005). Molecular organization in striated domains induced by transmembrane alpha-helical peptides in dipalmitoyl phosphatidylcholine bilayers. Biochemistry, 44, 2-10. https://doi.org/10.1021/bi048047a
van Duyl, B. Y., Meeldijk, J. D., Verkleij, A. J., Rijkers, D. T. S., Chupin, V. V., de Kruijff, B., & Killian, J. A. (2005). A synergistic effect between cholesterol and tryptophan-flanked transmembrane helices modulates membrane curvature. Biochemistry, 44(11), 4526-4532.
https://dspace.library.uu.nl/bitstream/handle/1874/7921/VanDuyl-A%2520synergistic%2520effect.pdf?sequence=2
Keyzer, J. J., van der Sluis, E. O., Spelbrink, R. E. J., Nijstad, N., de Kruijff, B., Nouwens, N., van der Does, C., & Driessen, A. J. M. (2005). Covalently dimerized SecA is functional in protein translocation. Journal of Biological Chemistry, 280, 35255-35260.
Kooijman, E. E., Carter, K. M., van Laar, E. G., Chupin, V., Burger, K. N. J., & de Kruijff, B. (2005). What makes the bioactive lipids phosphatidic acid and lysophosphatidic acid so special? Biochemistry, 44, 17007-17015.
https://dspace.library.uu.nl/bitstream/handle/1874/7924/Kooijman-What%2520makes%2520the%2520bioactive.pdf?sequence=2
de Kroon, A. I. P. M., Staffhorst, R. W. H. M., de Kruijff, B., & Burger, K. N. J. (2005). Cisplatin nanocapsules. Methods in Enzymology, 391, 118-125.
https://dspace.library.uu.nl/bitstream/handle/1874/7923/DeKroon-Cisplatin%2520nanocapsules.pdf?sequence=2
Kooijman, E. E., Chupin, V. V., Fuller, N. L., Kozlov, M. M., de Kruijff, B., Burger, K. N. J., & Rand, P. R. (2005). Spontaneous curvature of phosphatidic acid and lysophosphatidic acid. Biochemistry, 44, 2097-2102.
https://dspace.library.uu.nl/bitstream/handle/1874/7922/Kooijman-Spontaneous%2520curvature.pdf?sequence=2

2004

Scholarly publications

Hasper, H. E., De Kruijff, B., & Breukink, E. (2004). Assembly and stability of nisin-Lipid II pores. Biochemistry, 43(36), 11567-11575. https://doi.org/10.1021/bi049476b
Hsu, S-T. D., Breukink, E., Tischenko, E., Lutters, M. A. G., De Kruijff, B., Kaptein, R., Bonvin, A. M. J. J., & Van Nuland, N. A. J. (2004). The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics. Nature Structural and Molecular Biology, 11(10), 963-967. https://doi.org/10.1038/nsmb830
Boumann, H. A., de Kruijff, B., Heck, A. J. R., & de Kroon, A. I. P. M. (2004). The selective utilization of substrates in vivo by the phosphatidylethanolamine and phosphatidylcholine biosynthetic enzymes Ept1p and Cpt1p in yeast. FEBS Letters, 569, 173-177.
https://dspace.library.uu.nl/bitstream/handle/1874/14460/Boumann-The%2520selective%2520utilization.pdf?sequence=1
Bonev, B. B., Breukink, E. J., Swiezewska, E., de Kruijff, B., & Watts, A. (2004). Targeting extracellular pyrophosphates underpins the high selectivity of nisin. FASEB Journal, 18, 1862-1869.
https://dspace.library.uu.nl/bitstream/handle/1874/14608/Bonev-Targeting%2520extracellular.pdf?sequence=1
Kol, M. A., de Kroon, A. I. P. M., Killian, J. A., & de Kruijff, B. (2004). Transbilayer movement of phospholipids in biogenic membranes. Biochemistry, 43, 2673-2681.
https://dspace.library.uu.nl/bitstream/handle/1874/14618/Kol-Transbilayer%2520movement.pdf?sequence=1
Boumann, H. A., Chin, P. T. K., Heck, A. J. R., de Kruijff, B., & de Kroon, A. I. P. M. (2004). The yeast phospholipid N-methyltransferases catalyzing the synthesis of phosphatidylcholine preferentially convert di-C16:1 substrates both in vivo and in vitro. Journal of Biological Chemistry, 279, 40314-40319.
https://dspace.library.uu.nl/bitstream/handle/1874/14609/Boumann-The%2520yeast%2520phospholipid.pdf?sequence=1
Hasper, H. E., de Kruijff, B., & Breukink, E. J. (2004). Assembly and stability of nisin-lipid pores. Biochemistry, 43, 11567-11575.
https://dspace.library.uu.nl/bitstream/handle/1874/14616/Hasper-Assembly%2520and%2520stability.pdf?sequence=1
van den Brink - van der Laan, E., Chupin, V. V., Killian, J. A., & de Kruijff, B. (2004). Small alcohols destabilize the KcsA tetramer via their effect on the membrane lateral pressure. Biochemistry, 43, 5937-5942.
https://dspace.library.uu.nl/bitstream/handle/1874/14610/VandenBrink-Small%2520alcohols.pdf?sequence=1
Velinova, M. J., Staffhorst, R. W. H. M., Mulder, W. J. M., Dries, A. S., Jansen, B. A. J., de Kruijff, B., & de Kroon, A. I. P. M. (2004). Preparation and stability of lipid-coated nanocapsules of cisplatin: anionic phospholipid specificity. Biochimica et Biophysica Acta-Biomembranes, 1663, 135-142.
https://dspace.library.uu.nl/bitstream/handle/1874/14625/Velinova-Preparation%2520and%2520stability.pdf?sequence=1
Sparr, E. M., Engel, M. F. M., Sakharov, D., Sprong, M. G. H., Jacobs, J., de Kruijff, B., Höppener, J. W. M., & Killian, J. A. (2004). Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers. FEBS Letters, 577, 117-120.
https://dspace.library.uu.nl/bitstream/handle/1874/14621/Sparr-Islet%2520amyloid.pdf?sequence=1
Kramer, N. E., Smid, E. J., Kok, J., de Kruijff, B., Kuipers, O. P., & Breukink, E. J. (2004). Resistance of Gram-positive bacteria to nisin is not determined by Lipid II levels. FEMS Microbiology Letters, 239, 157-161.
https://dspace.library.uu.nl/bitstream/handle/1874/14620/Kramer-Resistance%2520of%2520Gram-positive.pdf?sequence=1
Ridder, A. N. J. A., Spelbrink, R. E. J., Demmers, J. A. A., Rijkers, D. T. S., Liskamp, R. M. J., Brunner, J., Heck, A. J. R., de Kruijff, B., & Killian, J. A. (2004). Photo-crosslinking analysis of preferential interactions between a transmembrane peptide and matching lipids. Biochemistry, 43, 4482-4489.
https://dspace.library.uu.nl/bitstream/handle/1874/14449/Ridder-Photo-crosslinking%2520analysis.pdf?sequence=1
Ganchev, D. N., Rijkers, D. T. S., Snel, M. M. E., Killian, J. A., & de Kruijff, B. (2004). Strength of integration of transmembrane α-helical peptides in lipid bilayers as determined by Atomic Force Spectroscopy. Biochemistry, 43(47), 14987-14993. https://doi.org/10.1021/bi048372y
Kol, M. A., Kuster, D. W. D., Boumann, H. A., de Cock, J. J. P. A., Heck, A. J. R., de Kruijff, B., & de Kroon, A. I. P. M. (2004). Uptake and remodeling of exogenous phosphatidylethanolamine in E. coli. Biochimica et Biophysica Acta, 1636, 205-212.
https://dspace.library.uu.nl/bitstream/handle/1874/14638/Kol-Uptake%2520and%2520remodeling.pdf?sequence=1
van Dalen, A., & de Kruijff, B. (2004). The role of lipids in membrane insertion and translocation of bacterial proteins. Biochimica et Biophysica Acta-Molecular Cell Research, 1694, 97-109.
https://dspace.library.uu.nl/bitstream/handle/1874/14613/VanDalen-The%2520role%2520of%2520lipids.pdf?sequence=1
van den Brink - van der Laan, E., Chupin, V. V., Killian, J. A., & de Kruijff, B. (2004). Stability of KcsA tetramer depends on membrane lateral pressure. Biochemistry, 43, 4240-4250.
https://dspace.library.uu.nl/bitstream/handle/1874/14627/VandenBrink-Stability.pdf?sequence=1

Other output

van Duyl, B. Y., Rijkers, D. T. S., Chupin, V. V., de Kruijff, B., & Killian, J. A. (2004). Isotropic phase formation in bilayer lipids: synergistic effect of cholesterol and transmembrane peptides. B23. Abstract from Unknown event, Asilomar, USA.

2003

Scholarly publications

Hsu, S-T. D., Breukink, E., Bierbaum, G., Sahl, H-G., De Kruijff, B., Kaptein, R., Van Nuland, N. A. J., & Bonvin, A. M. J. J. (2003). NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles: Conformational changes are a key to antimicrobial activity. Journal of Biological Chemistry, 278(15), 13110-13117. https://doi.org/10.1074/jbc.M211144200
Demmers, J. A. A., van Dalen, A., de Kruijff, B., Heck, A. J. R., & Killian, J. A. (2003). Interaction of the K+ channel KcsA with membrane phospholipids as studied by ESI mass spectrometry. FEBS Letters, 541, 28-32. https://www.sciencedirect.com/science/article/pii/S0014579303002825
Boumann, H. A., Damen, J. M. A., Versluis, C., Heck, A. J. R., de Kruijff, B., & de Kroon, A. I. P. M. (2003). The two biosynthetic routes leading to posphatidylcholine in yeast produce different sets of molecular species. Evidence for lipid remodeling. Biochemistry, 42, 3054-3059.
https://dspace.library.uu.nl/bitstream/handle/1874/14364/Boumann-The%2520two%2520biosynthetic.pdf?sequence=1
van Kan, E. J. M., Ganchev, D. N., Snel, M. M. E., Chupin, V. V., van der Bent, A., & de Kruijff, B. (2003). The peptide antibiotic clavanin A interacts strongly and specifically with lipid bilayers. Biochemistry, 42, 11366-11372. https://doi.org/10.1021/bi0349017
Breukink, E. J., van Heusden, H. E., Bonnici, P. J., Swiezewska, E., Brunner, L., Walker, S. M., Heck, A. J. R., & de Kruijff, B. (2003). Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes. Journal of Biological Chemistry, 278, 19898-19903.
https://dspace.library.uu.nl/bitstream/handle/1874/14365/Breukink-Lipid%2520II%2520is%2520an%2520intrinsic.pdf?sequence=1
Kooijman, E. E., Chupin, V. V., de Kruijff, B., & Burger, K. N. J. (2003). Modulation of membrane curvature by phosphatidic acid and lysophosphatidic acid. Traffic, 4, 162-172.
van Duyl, B. Y., Ganchev, D. N., Chupin, V. V., de Kruijff, B., & Killian, J. A. (2003). Sphingomyelin is much more effective than saturated phosphatidylcholine in excluding unsaturated phosphatidylcholine from domains formed with cholesterol. FEBS Letters, 547(1-3), 101-106. https://doi.org/10.1016/S0014-5793(03)00678-1
Kol, M. A., van Dalen, A., de Kroon, A. I. P. M., & de Kruijff, B. (2003). Translocation of phospholipids is facilitated by a subset of membrane-spanning proteins of the bacterial cytoplasmic membrane. Journal of Biological Chemistry, 278, 24586-24593.
van den Brink - van der Laan, E., Boots, J. W. P., Spelbrink, R. E. J., Kool, G. M., Breukink, E. J., Killian, J. A., & de Kruijff, B. (2003). Membrane interaction of the glycolsyltransferase MurG: a special role for cardiolipin. Journal of Bacteriology, 185, 3773-3779.
https://dspace.library.uu.nl/bitstream/handle/1874/14366/VandenBrink-Membrane%2520interaction.pdf?sequence=1
Dekker, C. G., de Kruijff, B., & Gros, P. (2003). Crystal structure of SecB from Escherichia coli. Journal of Structural Biology, 144, 313-319.
https://dspace.library.uu.nl/bitstream/handle/1874/14368/Dekker-Crystal%2520structure.pdf?sequence=1
de Kroon, A. I. P. M., Koorengevel, M. C., Vromans, T. A. M., & de Kruijff, B. (2003). Continuous Equilibration of Phosphatidylcholine and Its Precursors between Endoplasmic Reticulum and Mitochondria in Yeast. Molecular Biology of the Cell, 14(5), 2142-2150. https://doi.org/10.1091/mbc.e02-08-0460
Kol, M. A., van Laak, A. N. C., Rijkers, D. T. S., Killian, J. A., de Kroon, A. I. P. M., & de Kruijff, B. (2003). Phospholipid flop induced by transmembrane peptides in model membranes is modulated by lipid composition. Biochemistry, 42, 231-237.

2002

Scholarly publications

Janssen, M. J. F. W., de Jong, H. M., de Kruijff, B., & de Kroon, A. I. P. M. (2002). Cooperative activity of phospholipid-N-methyltransferases localized in different membranes. FEBS Letters, 513, 197-202.
https://dspace.library.uu.nl/bitstream/handle/1874/14360/Janssen-Cooperative%2520activity.pdf?sequence=1
Burger, K. N. J., Staffhorst, R. W. H. M., de Vijlder, H. C., Velinova, M. J., Bomans, P. H., Frederik, P. M., & de Kruijff, B. (2002). Nanocapsules: lipid-coated aggregates of cisplatin with high toxicity. Nature Medicine, 8, 81-84.
Ridder, A. N. J. A., Thissen, L., Killian, J. A., & de Kruijff, B. (2002). Insertion and glycosylation of Pf3-derived membrane proteins in microsomes. FEBS Letters, 512, 341-344.
https://dspace.library.uu.nl/bitstream/handle/1874/14247/Ridder-Insertion%2520and%2520glycosylation.pdf?sequence=1
Chupin, V. V., Boots, J. W. P., Killian, J. A., Demel, R. A., & de Kruijff, B. (2002). Thermotropic phase behavior of monoglyceride-dicetylphosphate dispersions and interactions with proteins: a 2H and 31P study. Biophysical Journal, 82, 843-851.
https://dspace.library.uu.nl/bitstream/handle/1874/14254/Chupin-Thermotropic%2520phase.pdf?sequence=1
van Dalen, A., Hegger, S., Killian, J. A., & de Kruijff, B. (2002). Influence of lipids on membrane assembly and stability of the potassium channel KcsA. FEBS Letters, 525, 33-38.
https://dspace.library.uu.nl/bitstream/handle/1874/14256/VanDalen-Infuence%2520of%2520lipids.pdf?sequence=1
van Dalen, A., van der Laan, M., Driessen, A. J. M., Killian, J. A., & de Kruijff, B. (2002). Components required for membrane assembly of newly synthesized K+ channel KcsA. FEBS Letters, 511, 51-58.
https://dspace.library.uu.nl/bitstream/handle/1874/14255/VanDalen-Components%2520required.pdf?sequence=1
Hsu, S., Breukink, E. J., de Kruijff, B., Kaptein, R., Bonvin, A. M. J. J., & van Nuland, N. A. J. (2002). Mapping the targeted membrane pore formation mechanism by solution NMR: the nisin Z and lipid II interaction in SDS micelles. Biochemistry, 41, 7670-7676. https://doi.org/10.1021/bi025679t
Kol, M. A., de Kruijff, B., & de Kroon, A. I. P. M. (2002). Phospholipid flip-flop in biogenic membranes: what is needed to connect opposite sides. Seminars in cell & developmental biology, 13, 163-170. https://www.sciencedirect.com/science/article/pii/S1084952102000447
van Heusden, H. E., de Kruijff, B., & Breukink, E. J. (2002). Lipid II induces a transmembrane orientation of the pore-forming peptide lantibiotic nisin. Biochemistry, 41, 12171-12178. https://pubs.acs.org/doi/abs/10.1021/bi026090x
Ridder, A. N. J. A., van de Hoef, W., Stam, J., Kuhn, A., de Kruijff, B., & Killian, J. A. (2002). Importance of hydrophobic matching for spontaneous insertion of a single-spanning membrane protein. Biochemistry, 41, 4946-4952.
van Kan, E. J. M., Demel, R. A., Breukink, E. J., van der Bent, A., & de Kruijff, B. (2002). Clavanin permeabilizes target membranes via two distinctly different pH-dependent mechanisms. Biochemistry, 41(24), 7529-7539. https://pubs.acs.org/doi/abs/10.1021/bi012162t
Janssen, M. J. F. W., van Voorst, F., Ploeger, G. E. J., Mose Larsen, P., Larsen, M. R., de Kroon, A. I. P. M., & de Kruijff, B. (2002). Photolabeling identifies an interaction between phosphatidylcholine and glycerol-3-phosphate dehydrogenase (Gut2p) in yeast mitochondria. Biochemistry, 41, 5702-5711. https://www.researchgate.net/publication/11389915_Photolabeling_Identifies_an_Interaction_between_Phosphatidylcholine_and_Glycerol-3-phosphate_Dehydrogenase_Gut2p_in_Yeast_Mitochondria
Porcelli, I., de Leeuw, E., Wallis, R., van den Brink - van der Laan, E., de Kruijff, B., Wallace, B. A., Palmer, T., & Berks, B. B. (2002). Characterization and membrane assembly of the TatA component of the Escherichia coli twin-arginine protein transport system. Biochemistry, 41, 13690-13697.
https://dspace.library.uu.nl/bitstream/handle/1874/14361/Porcelli%2520Characterization.pdf?sequence=1
Janssen, M. J. F. W., de Kruijff, B., & de Kroon, A. I. P. M. (2002). Phosphate is required to maintain the outer membrane integrity and membrane potential of respiring yeast mitochondria. Analytical Biochemistry, 300, 27-33. https://www.sciencedirect.com/science/article/pii/S0003269701954387

2001

Scholarly publications

Van Kraaij, C., Breukink, E., Rollema, H. S., Bongers, R. S., Kosters, H. A., De Kruijff, B., & Kuipers, O. P. (2001). Engineering a disulfide bond and free thiols in the lantibiotic nisin Z. European Journal of Biochemistry, 267(3), 901-909. https://doi.org/10.1046/j.1432-1327.2000.01075.x
de Planque, M. R. R., Goormaghtigh, E., Greathouse, D. V., Koeppe, R. E., Kruijtzer, J. A. W., Liskamp, R. M. J., de Kruijff, B., & Killian, J. A. (2001). Sensitivity of single membrane-spanning alpha-helical peptides to hydrophobic mismatch with a lipid bilayer: effects on backbone structure, orientation, and extent of membrane incorporation. Biochemistry, 40, 5000-5010.
Vereijken, I. J., Chupin, V. V., Demel, R. A., Smeekens, J. C. M., & de Kruijff, B. (2001). Fructans insert between the headgroups of phopholipids. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1510, 307-320.
de Kroon, A. I. P. M., Ahting, U., Niggemeyer, B., Neupert, W., de Kruijff, B., Lill, R., & Diekert, K. (2001). Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane. EMBO Journal, 20, 5626-5635.
Inoue, K., Demel, R. A., de Kruijff, B., & Keegstra, K. (2001). The N-terminal portion of the preToc75 transit peptide interacts with membrane lipids and inhibits binding and import of precursor proteins isolated chloroplasts. European Journal of Biochemistry, 268, 4036-4043.
de Planque, M. R. R., Goormaghtigh, E., Greathouse, D. V., Koeppe II, R. E., Kruijtzer, J. A. W., Liskamp, R. M. J., de Kruijff, B., & Killian, J. A. (2001). Sensitivity of single membrane spanning a-helical peptides to hydrophobic mismatch with a lipid bilayer: effects on backbone structure, orientation, and extent of membrane corporation. Biochemistry, 40, 5000-5010.
van den Brink - van der Laan, E., Dalbey, R. E., Demel, R. A., Killian, J. A., & de Kruijff, B. (2001). Effect of nonbilayer lipids on membrane binding and insertion of the catalytic domain of leader peptidase. Biochemistry, 40, 9677-9684.
Chupin, V. V., Boots, J. W. P., Killian, J. A., Demel, R. A., & de Kruijff, B. (2001). Lipid organization and dynamics of the monostearoylglycerol-water system. Chemistry and Physics of Lipids, 109, 15-28.
Kol, M. A., de Kroon, A. I. P. M., Rijkers, D. T. S., Killian, J. A., & de Kruijff, B. (2001). Membrane-spanning peptides induce phospholipid flop: a model for phospholipid translocation across the inner membrane of E. coli. Biochemistry, 40, 10500-10506.
Wiedemann, I., Breukink, E. J., van Kraaij, C., Kuipers, O. P., Bierbaum, G., de Kruijff, B., & Sahl, H-G. (2001). Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. Journal of Biological Chemistry, 276, 1772-1779.
Agianian, B., Weik, M., Zaccai, G., Kroon, J., de Kruijff, B., & Gros, P. (2001). Biophysical characterization of the influence of salt on tetrameric SecB. Biophysical Journal, 81, 455-462.
Boots, J. W. P., Chupin, V. V., Killian, J. A., Demel, R. A., & de Kruijff, B. (2001). The specificity of monoglyceride-protein interactions and the mechanism of the protein induced Lbeta to coagel phase transition. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1510, 401-413.
van Kan, E. J. M., van der Bent, A., Demel, R. A., & de Kruijff, B. (2001). Membrane activity of the peptide antibiotic clavanin and the importance of its glycine residues. Biochemistry, 40, 6398-6405.

2000

Scholarly publications

Janssen, M. J. F. W., Koorengevel, M. C., De Kruijff, B., & De Kroon, A. I. P. M. (2000). The phosphatidylcholine to phosphatidylethanolamine ratio of Saccharomyces cerevisiae varies with the growth phase. Yeast, 16(7), 641-650. https://doi.org/10.1002/(SICI)1097-0061(200005)16:7<641::AID-YEA578>3.0.CO;2-U
Breukink, E., Ganz, P., De Kruijff, B., & Seelig, J. (2000). Binding of nisin Z to bilayer vesicles as determined with isothermal titration calorimetry. Biochemistry, 39(33), 10247-10254. https://doi.org/10.1021/bi000915q
Wienk, H. L. J., Wechselberger, R. W., Czisch, M., & De Kruijff, B. (2000). Structure, dynamics, and insertion of a chloroplast targeting peptide in mixed micelles. Biochemistry, 39(28), 8219-8227. https://doi.org/10.1021/bi000110i
van den Wijngaard, P. W. J., Thompson, S. J., Wienk, H. L. J., de Kruijff, B., & Vredenberg, W. J. (2000). Further analysis of the involvement of the envelope anion channel PIRAC in chloroplast protein import. European Journal of Biochemistry, 267, 3812-3817.
Wijngaard, P., Demmers, J. A. A., Thompson, S. J., Wienk, H. L. J., de Kruijff, B., & Vredenberg, W. J. (2000). Further analysis of the involvement of the envelope anion channel PIRAC in chlorplast protein import. European Journal of Biochemistry, 267, 3812-3817.

1999

Scholarly publications

Breukink, E., & De Kruijff, B. (1999). The lantibiotic nisin, a special case or not? Biochimica et Biophysica Acta - Biomembranes, 1462(1-2), 223-234. https://doi.org/10.1016/S0005-2736(99)00208-4
Breukink, E., Wiedemann, I., Van Kraaij, C., Kuipers, O. P., Sahl, H-G., & De Kruijff, B. (1999). Use of the cell wail precursor lipid II by a pore-forming peptide antibiotic. Science, 286(5448), 2361-2364. https://doi.org/10.1126/science.286.5448.2361
Wienk, H. L. J., & De Kruijff, B. (1999). Expression, isolation, and characterization of a chloroplast targeting peptide. Protein Expression and Purification, 17(3), 345-350. https://doi.org/10.1006/prep.1999.1139
Wienk, H. L. J., Czisch, M., & De Kruijff, B. (1999). The structural flexibility of the preferredoxin transit peptide. FEBS Letters, 453(3), 318-326. https://doi.org/10.1016/S0014-5793(99)00653-5
de Planque, M. R. R., Kruijtzer, J. A. W., Liskamp, R. M. J., Marsh, D., Greathouse, D. V., Koeppe II, R. E., de Kruijff, B., & Killian, J. A. (1999). Different membrane anchoring positions of tryptophan and lysine in synthetic transmembrane alpha-helical peptides. Journal of Biological Chemistry, 274, 20839-20846.
Dekker, C. G., de Korte-Kool, G., Kroon, J., de Kruijff, B., & Gros, P. (1999). Crystals of acetylated SecB diffract to 2.3 Angstrom resolution. Journal of Structural Biology, 127, 237-242.

1998

Scholarly publications

Van Kraaij, C., Breukink, E., Noordermeer, M. A., Demel, R. A., Siezen, R. J., Kuipers, O. P., & De Kruijff, B. (1998). Pore formation by nisin involves translocation of its C-terminal part across the membrane. Biochemistry, 37(46), 16033-16040. https://doi.org/10.1021/bi980931b
Breukink, E., Van Kraaij, C., Van Dalen, A., Demel, R. A., Siezen, R. J., De Kruijff, B., & Kuipers, O. P. (1998). The orientation of nisin in membranes. Biochemistry, 37(22), 8153-8162. https://doi.org/10.1021/bi972797l

1997

Scholarly publications

Van Kraaij, C., Breukink, E., Rollema, H. S., Siezen, R. J., Demel, R. A., De Kruijff, B., & Kuipers, O. P. (1997). Influence of charge differences in the C-terminal part of nisin on antimicrobial activity and signaling capacity. European Journal of Biochemistry, 247(1), 114-120.
Breukink, E., Van Kraaij, C., Demel, R. A., Siezen, R. J., Kuipers, O. P., & De Kruijff, B. (1997). The C-terminal region of nisin is responsible for the initial interaction of nisin with the target membrane. Biochemistry, 36(23), 6968-6976. https://doi.org/10.1021/bi970008u

1996

Scholarly publications

Van Raalte, A. L. J., Demel, R. A., Verberkmoes, G., Breukink, E., Keller, R. C. A., & De Kruijff, B. (1996). Influence of the signal sequence and chaperone SecB on the interaction between precursor protein prePhoE and phospholipids. European Journal of Biochemistry, 235(1-2), 207-214.

1995

Scholarly publications

Breukink, E., Nouwen, N., Van Raalte, A., Mizushima, S., Tommassen, J., & De Kruijff, B. (1995). The C terminus of SecA is involved in both lipid binding and SecB binding. Journal of Biological Chemistry, 270(14), 7902-7907. https://doi.org/10.1074/jbc.270.14.7902
Chupin, V., Killian, J. A., Breg, J., de Jongh, H. H., Boelens, R., Kaptein, R., & de Kruijff, B. (1995). PhoE signal peptide inserts into micelles as a dynamic helix-break-helix structure, which is modulated by the environment. A two-dimensional 1H NMR study. Biochemistry, 34(36), 11617-24.
Chupin, V., Killian, J. A., Breg, J., De Jongh, H. H. J., Boelens, R., Kaptein, R., & De Kruijff, B. (1995). PhoE signal peptide inserts into micelles as a dynamic helix-break-helix structure, which is modulated by the environment. A two-dimensional1H NMR study. Biochemistry, 34(36), 11617-11624. https://doi.org/10.1021/bi00036a038
Pilon, M., Wienk, H., Sips, W., De Swaaf, M., Talboom, I., Van 'T Hof, R., De Korte-Kool, G., Demel, R., Weisbeek, P., & De Kruijff, B. (1995). Functional domains of the ferredoxin transit sequence involved in chloroplast import. Journal of Biological Chemistry, 270(8), 3882-3893. https://doi.org/10.1074/jbc.270.8.3882

1994

Scholarly publications

Kusters, R., Breukink, E., Gallusser, A., Kuhn, A., & De Kruijff, B. (1994). A dual role for phosphatidylglycerol in protein translocation across the Escherichia coli inner membrane. Journal of Biological Chemistry, 269(2), 1560-1563.
Rietveld, T. G., Chupin, V. V., Koorengevel, M. C., Wienk, H. L. J., Dowhan, W., & De Kruijff, B. (1994). Regulation of lipid polymorphism is essential for the viability of phosphatidylethanolamine-deficient Escherichia coli cells. Journal of Biological Chemistry, 269(46), 28670-28675.

1993

Scholarly publications

Van der Wolk, J., Klose, M., Breukink, E., Demel, R. A., De Kruijff, B., Freudl, R., & Driessen, A. J. M. (1993). Characterization of a Bacillus subtilis SecA mutant protein deficient in translocation ATPase and release from the membrane. Molecular Microbiology, 8(1), 31-42.
Breukink, E., Keller, R. C. A., & De Kruijff, B. (1993). Nucleotide and negatively charged lipid-dependent vesicle aggregation caused by SecA. Evidence that SecA contains two lipid-binding sites. FEBS Letters, 331(1-2), 19-24. https://doi.org/10.1016/0014-5793(93)80289-7

1992

Scholarly publications

Kruijff, B. D., Breukink, E., Demel, R. A., T Hof, R. V., Jongh, H. H. J. D., Jordi, W., Keller, R. C. A., Killian, J. A., Kroon, A. I. P. M. D., Kusters, R., & Pilon, M. (1992). Lipid involvement in protein translocation. New Comprehensive Biochemistry, 22(C), 85-101. https://doi.org/10.1016/S0167-7306(08)60085-X
Breukink, E., Demel, R. A., De Korte-Kool, G., & De Kruijff, B. (1992). SecA insertion into phospholipids is stimulated by negatively charged lipids and inhibited by ATP: A monolayer study. Biochemistry, 31(4), 1119-1124.
Breukink, E., Kusters, R., & De Kruijff, B. (1992). In-vitro studies on the folding characteristics of the Escherichia coli precursor protein prePhoE. Evidence that SecB prevents the precursor from aggregating by forming A functional complex. European Journal of Biochemistry, 208(2), 419-425.

1989

Scholarly publications

Kusters, R., de Vrije, T., Breukink, E., & De Kruijff, B. (1989). SecB protein stabilizes a translocation-competent state of purified prePhoE protein. Journal of Biological Chemistry, 264(35), 20827-20830.
Tommassen, J., de Vrije, T., de Cock, H., Bosch, D., & de Kruijff, B. (1989). Involvement of membrane lipids in protein export in Escherichia coli. Journal of cell science. Supplement, 11, 73-83.

1980

Scholarly publications

Gerritsen, W. J., Henricks, P. A. J., de Kruijff, B., & van Deenen, L. L. M. (1980). The transbilayer movement of phosphatidylcholine in vesicles reconstituted with intrinsic proteins from the human erythrocyte membrane. Biochimica et Biophysica Acta - Biomembranes, 600(3), 607-619. https://doi.org/10.1016/0005-2736(80)90464-2

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