Dr. Boris Tefsen
Assistant Professor
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Publications
2026
Scholarly publications
Sahu, A., Xie, Z., Cheng, H. J., Omoboyowa, D. A., Zhang, L., Zhai, X. C., Bitter, W., Ruiz-Carrillo, D., Tefsen, B., Li, J. M., & Yang, Y. (2026). Impairment of two non-essential LytR-cpsA-psr (Lcp) cell wall ligases decelerate cell wall assembly in Mycolicibacterium smegmatis. BMC Microbiology, 26(1), Article 194. [DOI] [Portal]
2025
Scholarly publications
2023
Scholarly publications
Craig, P., Ng, R., Liu, Y., Tefsen, B., & Linsen, S. (2023). BioChipVis: An information visualization interface for explainable biochip data classification. Electronic Imaging, 35, 1-7. Article 404. [DOI] [Repository]
Zhang, X., Zhu, Y., Li, B., Tefsen, B., Wang, Z., & Wells, M. (2023). We need to plan streamlined environmental impact assessment for the future X-Press Pearl disasters. Marine Pollution Bulletin, 188, Article 114705. [DOI] [Repository]
Li, B., Zhang, X., Wu, G., Qin, B., Tefsen, B., & Wells, M. (2023). Toxins from harmful algal blooms: How copper and iron render chalkophore a predictor of microcystin production. Water Research, 244, Article 120490. [DOI] [Repository]
Zha, L., Zhang, X., Cheng, Y., Xu, Q., Liu, L., Chen, S., Lu, Z., Guo, J., & Tefsen, B. (2023). Intravenous Polymyxin B as Adjunctive Therapy to High-Dose Tigecycline for the Treatment of Nosocomial Pneumonia Due to Carbapenem-Resistant Acinetobacter baumannii and Klebsiella pneumoniae: A Propensity Score-Matched Cohort Study. Antibiotics, 12(2), Article 273. [DOI] [Repository]
Lioe, T. S., Xie, Z., Wu, J., Li, W., Sun, L., Feng, Q., Sekar, R., Tefsen, B., & Ruiz-Carrillo, D. (2023). The Mycobacterium tuberculosis prolyl dipeptidyl peptidase cleaves the N-terminal peptide of the immunoprotein CXCL-10. Biological Chemistry, 404(6). [DOI] [Repository]
2022
Scholarly publications
Zha, L., Li, S., Ren, Z., Li, X., Zhang, D., Zou, Y., Pan, L., Xu, Q., Rui, Z., Chen, S., Yang, G., Chen, Z., Tefsen, B., & Guo, J. (2022). Clinical management of infections caused by carbapenem-resistant Klebsiella pneumoniae in critically ill patients: A nationwide survey of tertiary hospitals in mainland China. The Journal of Infection, 84(6), e108-e110. [DOI]
Zhang, X., Li, B., Schillereff, D. N., Chiverrell, R. C., Tefsen, B., & Wells, M. (2022). Whole-cell biosensors for determination of bioavailable pollutants in soils and sediments: Theory and practice. Science of the Total Environment, 811, Article 152178. [DOI]
Li, B., Zhang, X., Tefsen, B., & Wells, M. (2022). From speciation to toxicity: Using a "Two-in-One" whole-cell bioreporter approach to assess harmful effects of Cd and Pb. Water Research, 217, Article 118384. [DOI]
Zhang, X., Barceló, D., Clougherty, R. J., Gao, B., Harms, H., Tefsen, B., Vithanage, M., Wang, H., Wang, Z., & Wells, M. (2022). “Potentially Toxic Element”─Something that Means Everything Means Nothing. Environmental Science & Technology, 56(17), 11922–11925. [DOI] [Repository]
Zha, L., Li, X., Ren, Z., Zhang, D., Zou, Y., Pan, L., Li, S., Chen, S., & Tefsen, B. (2022). Pragmatic Comparison of Piperacillin/Tazobactam versus Carbapenems in Treating Patients with Nosocomial Pneumonia Caused by Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae. Antibiotics, 11(10). [DOI] [Repository]
Craig, P., Ng, R., Tefsen, B., Linsen, S., Liu, Y., & Hendel, J. (2022). Information Visualisation for Antibiotic Detection Biochip Design and Testing. Processes, 10(12). [DOI] [Repository]
2021
Scholarly publications
Zha, L., Zhang, D., Pan, L., Ren, Z., Li, X., Zou, Y., Li, S., Luo, S., Yang, G., & Tefsen, B. (2021). Tigecycline in the Treatment of Ventilator-Associated Pneumonia Due to Stenotrophomonas maltophilia: A Multicenter Retrospective Cohort Study. Infectious Diseases and Therapy, 10(4), 2415-2429. [DOI]
Li, B., Zhang, X., Deng, J., Cheng, Y., Chen, Z., Qin, B., Tefsen, B., & Wells, M. (2021). A new perspective of copper-iron effects on bloom-forming algae in a highly impacted environment. Water Research, 195, Article 116889. [DOI]
Zha, L., Shen, Y., Pan, L., Han, M., Yang, G., Teng, X., & Tefsen, B. (2021). Follow-up study on pulmonary function and radiological changes in critically ill patients with COVID-19. The Journal of Infection, 82(1), 159-198. [DOI]
Guo, M., Hui, L., Nie, Y., Tefsen, B., & Wu, Y. (2021). ZIKV viral proteins and their roles in virus-host interactions. Science China Life Sciences, 64(5), 709-719. [DOI]
Pan, L., Xu, Q., Kuang, X., Zhang, X., Fang, F., Gui, L., Li, M., Tefsen, B., Zha, L., & Liu, H. (2021). Prevalence and factors associated with post-traumatic stress disorder in healthcare workers exposed to COVID-19 in Wuhan, China: a cross-sectional survey. BMC Psychiatry, 21(1), 572. [DOI]
2020
Scholarly publications
Zhang, X., Li, B., Deng, J., Qin, B., Wells, M., & Tefsen, B. (2020). Advances in freshwater risk assessment: improved accuracy of dissolved organic matter-metal speciation prediction and rapid biological validation. Ecotoxicology and Environmental Safety, 202, Article 110848. [DOI]
Zhang, X., Li, B., Deng, J., Qin, B., Wells, M., & Tefsen, B. (2020). Quantitative high-throughput approach to chalkophore screening in freshwaters. Science of the Total Environment, 735, Article 139476. [DOI]
Zha, L., Shen, J., Tefsen, B., Wang, Y., Lu, W., & Xu, Q. (2020). Clinical features and outcomes of adult COVID-19 patients co-infected with Mycoplasma pneumoniae. The Journal of Infection, 81(3), e12-e15. [DOI]
Zhang, X., Li, B., Deng, J., Qin, B., Wells, M., & Tefsen, B. (2020). Regional-scale investigation of dissolved organic matter and lead binding in a large impacted lake with a focus on environmental risk assessment. Water Research, 172, Article 115478. [DOI]
Zha, L., Pan, L., Guo, J., French, N., Villanueva, E. V., & Tefsen, B. (2020). Effectiveness and Safety of High Dose Tigecycline for the Treatment of Severe Infections: A Systematic Review and Meta-Analysis. Advances in Therapy, 37(3), 1049-1064. [DOI]
Zha, L., Li, S., Pan, L., Tefsen, B., Li, Y., French, N., Chen, L., Yang, G., & Villanueva, E. V. (2020). Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19). The Medical journal of Australia, 212(9), 416-420. [DOI]
Zhang, T., van Die, I., Tefsen, B., van Vliet, S. J., Laan, L. C., Zhang, J., Ten Dijke, P., Wuhrer, M., & Belo, A. I. (2020). Differential O- and Glycosphingolipid Glycosylation in Human Pancreatic Adenocarcinoma Cells With Opposite Morphology and Metastatic Behavior. Frontiers in Oncology, 10, 732. [DOI]
2019
Scholarly publications
Wang, X., Chen, H., Chiodo, F., & Tefsen, B. (2019). Detection of human IgM and IgG antibodies by means of galactofuranose-coated and rhamnose-coated gold nanoparticles. Matters. https://sosjournals.s3.amazonaws.com/e4ll42HPFoVFoZbi.pdf
Zhang, X., Li, B., Xu, H., Wells, M., Tefsen, B., & Qin, B. (2019). Data on response of in situ algal phytoplankton assemblages to micronutrient treatment in small-scale mesocosms for a large hypereutrophic lake. Data in Brief, 24, Article 103778. [DOI]
Zhang, X., Li, B., Xu, H., Wells, M., Tefsen, B., & Qin, B. (2019). Effect of micronutrients on algae in different regions of Taihu, a large, spatially diverse, hypereutrophic lake. Water Research, 151, 500-514. [DOI]
2016
Scholarly publications
Zhao, X., Tefsen, B., Li, Y., Qi, J., Lu, G., Shi, Y., Yan, J., Xiao, H., & Gao, G. F. (2016). The NS1 gene from bat-derived influenza-like virus H17N10 can be rescued in influenza A PR8 backbone. Journal of General Virology, 97(8), 1797-1806. [DOI]
2015
Scholarly publications
Belo, A. I., van Vliet, S. J., Maus, A., Laan, L. C., Nauta, T. D., Koolwijk, P., Tefsen, B., & van Die, I. (2015). Hypoxia inducible factor 1α down regulates cell surface expression of α1,2-fucosylated glycans in human pancreatic adenocarcinoma cells. FEBS Letters, 589(18), 2359-2366. [DOI]
Park, J., Tefsen, B., Heemskerk, M. J., Lagendijk, E. L., van den Hondel, C. A. M. J. J., van Die, I., & Ram, A. F. J. (2015). Identification and functional analysis of two Golgi-localized UDP-galactofuranose transporters with overlapping functions in Aspergillus niger. BMC Microbiology, 15, 253. [DOI]
2014
Scholarly publications
Sun, M., Liu, J., Qi, J., Tefsen, B., Shi, Y., Yan, J., & Gao, G. F. (2014). Nα-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted nα-acetylpeptide presentation. The Journal of Immunology, 192(12), 5509-5519. [DOI]
Tefsen, B., Lu, G., Zhu, Y., Haywood, J., Zhao, L., Deng, T., Qi, J., & Gao, G. F. (2014). The N-terminal domain of PA from bat-derived influenza-like virus H17N10 has endonuclease activity. Journal of Virology, 88(4), 1935-1941. [DOI]
Wu, Y., Wu, Y., Tefsen, B., Shi, Y., & Gao, G. F. (2014). Bat-derived influenza-like viruses H17N10 and H18N11. Trends in Microbiology, 22(4), 183-191. [DOI]
Park, J., Tefsen, B., Arentshorst, M., Lagendijk, E., van den Hondel, C. A., van Die, I., & Ram, A. F. (2014). Identification of the UDP-glucose-4-epimerase required for galactofuranose biosynthesis and galactose metabolism in A. niger. Fungal Biology and Biotechnology, 1, Article 6. [DOI]
Chiodo, F., Marradi, M., Park, J., Ram, A. F. J., Penadés, S., van Die, I., & Tefsen, B. (2014). Galactofuranose-coated gold nanoparticles elicit a pro-inflammatory response in human monocyte-derived dendritic cells and are recognized by DC-SIGN. ACS Chemical Biology, 9(2), 383-389. [DOI]
Tefsen, B., Grijpstra, J., Ordonez Alvarez, S., Lammers, M., van Die, I., & De Cock, H. (2014). Deletion of the CAP10 gene of Cryptococcus neoformans results in a pleiotropic phenotype with changes in expression of virulence factors. Research in Microbiology, 165(6), 399-410. [DOI]
2013
Scholarly publications
Tefsen, B., & van Die, I. (2013). Glycosyltransferases in chemo-enzymatic synthesis of oligosaccharides. Methods in Molecular Biology, 1022, 357-367. [DOI]
Belo, A. I., van der Sar, A. M., Tefsen, B., & van Die, I. (2013). Galectin-4 Reduces Migration and Metastasis Formation of Pancreatic Cancer Cells. PLoS One, 8(6), Article e65957. [DOI]
van Vliet, S. J., Vuist, I. M., Lenos, K., Tefsen, B., Kalay, H., García-Vallejo, J. J., & van Kooyk, Y. (2013). Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). Journal of Biological Chemistry, 288(38), 27519-27532. [DOI]
Chiodo, F., Marradi, M., Tefsen, B., Snippe, H., van Die, I., & Penadés, S. (2013). High sensitive detection of carbohydrate binding proteins in an ELISA-solid phase assay based on multivalent glyconanoparticles. PLoS One, 8(8), Article e73027. [DOI]
2012
Scholarly publications
Tefsen, B., Lagendijk, E. L., Park, J., Akeroyd, M., Schachtschabel, D., Winkler, R., van Die, I., & Ram, A. F. J. (2012). Fungal α-arabinofuranosidases of glycosyl hydrolase families 51 and 54 show a dual arabinofuranosyl- and galactofuranosyl-hydrolyzing activity. Biological Chemistry, 393(8), 767-775. [DOI]
Tefsen, B., Ram, A. F. J., van Die, I., & Routier, F. H. (2012). Galactofuranose in eukaryotes: aspects of biosynthesis and functional impact. Glycobiology, 22(4), 456-469. [DOI]
2011
Scholarly publications
Aranzamendi, C., Tefsen, B., Jansen, M., Chiumiento, L., Bruschi, F., Kortbeek, T., Smith, D. F., Cummings, R. D., Pinelli, E., & Van Die, I. (2011). Glycan microarray profiling of parasite infection sera identifies the LDNF glycan as a potential antigen for serodiagnosis of trichinellosis. Experimental Parasitology, 129(3), 221-226. [DOI]
2010
Scholarly publications
Van Die, I. M., & Tefsen, B. (2010). GLYCAN ANTIGEN. (Patent No. WO2010130683). http://chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://patentimages.storage.googleapis.com/ac/d5/91/e99fb9c25afed2/WO2010130683A1.pdf
2009
Scholarly publications
Bos, M. P., Poolman, J., Tefsen, B., Tommassen, J. P. M., & Tefson, B. (2009). OUTER MEMBRANE VESICLES AND USES THEREOF. (Patent No. US2010047287). http://chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://patentimages.storage.googleapis.com/e8/f4/51/f4518f17c06c3b/US7628995.pdf
Tefsen, B., van Stijn, C. M. W., van den Broek, M., Kalay, H., Knol, J. C., Jimenez, C. R., & van Die, I. (2009). Chemoenzymatic synthesis of multivalent neoglycoconjugates carrying the helminth glycan antigen LDNF. Carbohydrate Research, 344(12), 1501-1507. [DOI]
van Stijn, C. M. W., van den Broek, M., van de Weerd, R., Visser, M., Taşdelen, I., Tefsen, B., & van Die, I. (2009). Regulation of expression and secretion of galectin-3 in human monocyte-derived dendritic cells. Molecular Immunology, 46(16), 3292-3299. [DOI]
Grijpstra, J., Tefsen, B., Van Die, I., & De Cock, H. (2009). The cryptococcus neoformans cap10 and cap59 mutant strains, affected in glucuronoxylomannan synthesis, differentially activate human dendritic cells. FEMS Immunology and Medical Microbiology, 57(2), 142-150. [DOI]
2007
Scholarly publications
Meyer, S., Tefsen, B., Imberty, A., Geyer, R., & van Die, I. (2007). The C-type lectin L-SIGN differentially recognizes glycan antigens on egg glycosphingolipids and soluble egg glycoproteins from Schistosoma mansoni. Glycobiology, 17(10), 1104-1119. [DOI]
2005
Scholarly publications
Bos, Martine, P., Poolman, J., Tefsen, B., & Tommassen, Johannes, Petrus, M. (2005). VACCINE. (Patent No. WO2005064021).
Tefsen, B., Geurtsen, J., Beckers, F., Tommassen, J., & de Cock, H. (2005). Lipopolysaccharide transport to the bacterial outer membrane in spheroplasts. Journal of Biological Chemistry, 280(6), 4504-4509. [DOI]
Tefsen, B., Bos, M. P., Beckers, F. H. R., Tommassen, J. P. M., & de Cock, J. J. P. A. (2005). MsbA is not required for phospholipid transport in Neisseria meningitidis. Journal of Biological Chemistry, 280(43), 35961-35966. [DOI]
Bos, M. P., Tefsen, B., Voet, P., Weynants, V., van Putten, J. P. M., & Tommassen, J. P. M. (2005). Function of neisserial outer membrane phospholipase a in autolysis and assessment of its vaccine potential. Infection and Immunity, 73(4), 2222-2231. [DOI]
2004
Scholarly publications
Bos, M. P., Tefsen, B., Geurtsen, J. J. G., & Tommassen, J. P. M. (2004). Identification of an outer membrane protein required for the transport of lipopolysaccharide to the bacterial cell surface. Proceedings of the National Academy of Sciences of the United States of America, 101(25), 9417-9422. [DOI] [Repository]