Publications
2021
Scholarly publications
Wouters, R., Michiels, C., Sannerud, R., Kleizen, B., Dillen, K., Vermeire, W., Ayala, A. E., Demedts, D., Schekman, R., & Annaert, W. (2021). Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum. Journal of Cell Biology, 220(9), 1-26. [e201911104]. https://doi.org/10.1083/jcb.201911104
Kleizen, B., van Willigen, M., Mijnders, M., Peters, F., Grudniewska, M., Hillenaar, T., Thomas, A., Kooijman, L., Peters, K. W., Frizzell, R., van der Sluijs, P., & Braakman, I. (2021). Co-Translational Folding of the First Transmembrane Domain of ABC-Transporter CFTR is Supported by Assembly with the First Cytosolic Domain. Journal of Molecular Biology, 433(13), 1-24. [166955]. https://doi.org/10.1016/j.jmb.2021.166955
2019
Scholarly publications
Kleizen, B., Hunt, J. F., Callebaut, I., Hwang, T. C., Sermet-Gaudelus, I., Hafkemeyer, S., & Sheppard, D. N. (2019). CFTR: New insights into structure and function and implications for modulation by small molecules. Journal of Cystic Fibrosis, 19(suppl. 1), s19-s24. https://doi.org/10.1016/j.jcf.2019.10.021
Van Willigen, M., Vonk, A. M., Yeoh, H. Y., Kruisselbrink, E., Kleizen, B., Van Der Ent, C. K., Egmond, M. R., De Jonge, H. R., Braakman, I., Beekman, J. M., & Van Der Sluijs, P. (2019). Folding-function relationship of the most common cystic fibrosis-causing CFTR conductance mutants. Life Science Alliance, 2(1), [e201800172]. https://doi.org/10.26508/lsa.201800172
McCaul, N., Yeoh, H. Y., van Zadelhoff, G., Lodder, N., Kleizen, B., & Braakman, I. (2019). Analysis of Protein Folding, Transport, and Degradation in Living Cells by Radioactive Pulse Chase. Journal of Visualized Experiments, (144). https://doi.org/10.3791/58952
2017
Scholarly publications
Kirchner, S., Cai, Z., Rauscher, R., Kastelic, N., Anding, M., Czech, A., Kleizen, B., Ostedgaard, L. S., Braakman, I., Sheppard, D. N., & Ignatova, Z. (2017). Alteration of protein function by a silent polymorphism linked to tRNA abundance. PLoS Biology, 15(5). https://doi.org/10.1371/journal.pbio.2000779
Peters, F., Sahasrabudhe, P., Gross-Wilde, H., Kleizen, B., Conrath, K., & Braakman, I. (2017). Deciphering the mode of action of clinically relevant next generation c2 corrector compounds GLPG2737 and GLPG3221. Pediatric Pulmonology, 52, 230-231. https://doi.org/10.1002/ppul.23840
Mijnders, M., Kleizen, B., & Braakman, I. (2017). Correcting CFTR folding defects by small-molecule correctors to cure cystic fibrosis. Current Opinion in Pharmacology, 34, 83-90. https://doi.org/10.1016/j.coph.2017.09.014
Other output
Mijnders, M., Musch, S., Peters, F., Conrath, K., Braakman, I., & Kleizen, B. (2017). Mutations in the second cytoplasmic loop of CFTR suggest distinct mode of action between potentiators VX-770 and glpg1837. S224. https://doi.org/10.1002/ppul.23840
2016
Scholarly publications
Braakman, I., Kleizen, B., Mijnders, M., Van Willigen, M., Peters, F., Frizzell, R. A., & Peters, K. W. (2016). Corrector and potentiator action on CFTR domain assembly. Pediatric Pulmonology, 51, 142. https://doi.org/10.1002/ppul.23575
Peters, F., Mijnders, M., Andrews, M., Van Der Plas, S., Conrath, K., Braakman, I., & Kleizen, B. (2016). The novel potentiator GLPG1837 modulates CFTR through different mode of action than Ivacaftor (kalydeco). Pediatric Pulmonology, 51, 195. https://doi.org/10.1002/ppul.23576
2015
Scholarly publications
Peters, F., Kleizen, B., Andrews, M., Van Der Plas, S., Tse, C., Conrath, K., & Braakman, I. (2015). Potentiators: How do they impact the fate of CFTR during biogenesis? Pediatric Pulmonology, 50, 210. https://doi.org/10.1002/ppul.23297
2013
Scholarly publications
Kleizen, B., & Braakman, I. (2013). A sweet send-off. Science, 340(6135), 930-931. https://doi.org/10.1126/science.1239294
Krämer, A., Mentrup, T., Kleizen, B., Rivera-Milla, E., Reichenbach, D., Enzensperger, C., Nohl, R., Täuscher, E., Görls, H., Ploubidou, A., Englert, C., Werz, O., Arndt, H-D., & Kaether, C. (2013). Small molecules intercept Notch signaling and the early secretory pathway. Nature Chemical Biology, 9, 731-738. https://doi.org/10.1038/nchembio.1356
2010
Scholarly publications
Hoelen, H. M., Kleizen, B., Schmidt, A., Richardson, J., Charitou, P., Braakman, L. J., & Thomas, P. J. (2010). The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domain. PLoS One, 5(11), 1-10. https://doi.org/10.1371/journal.pone.0015458
https://dspace.library.uu.nl/bitstream/handle/1874/196856/The-primary-folding-defect-and-rescue_2010_PLoS-ONE.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/196856/The-primary-folding-defect-and-rescue_2010_PLoS-ONE.pdf?sequence=1
2006
Scholarly publications
Benham, A. M., Kleizen, B., Sitia, R., & Braakman, I. (2006). Conformation dependent redox sensing of the human ER protein Ero1-Lα. Journal of Biological Chemistry.
Kleizen, B., van Vlijmen, T., de Jonge, H. R., & Braakman, L. J. (2006). Folding of CFTR is predominantly cotranslational. Molecular Cell, 20, 277-287.
2005
Scholarly publications
Liscaljet, I. M., Kleizen, B., & Braakman, I. (2005). Studying protein folding in vivo. In J. Buchner, & T. Kiefhaber (Eds.), Handbook of protein folding (pp. 73-104)
Kleizen, B., van Vlijmen, T., de Jonge, H., & Braakman, I. (2005). CFTR folds predominantly co-translational. Molecular Cell, 20(2), 277-287.
https://dspace.library.uu.nl/bitstream/handle/1874/7721/42%2520Kleizen%2520MollCell%252005.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/7721/42%2520Kleizen%2520MollCell%252005.pdf?sequence=2
Kleizen, B. (2005). Folding of CFTR at the endoplasmic reticulum. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Utrecht University.
2004
Scholarly publications
Kleizen, B., & Braakman, I. (2004). Protein folding in the ER. Current Opinion in Cell Biology, 16(4), 343-349.
Kleizen, B., & Braakman, L. J. (2004). Protein folding and quality control in the endoplasmic reticulum. Current Opinion in Cell Biology, 16(5), 343-349.
2000
Scholarly publications
Kleizen, B., Braakman, L. J., & de Jonge, H. R. (2000). Regulated trafficking of the CTR chloride channel. European Journal of Cell Biology, 79(8), 544-556.
Sagt, C. M. J., Kleizen, B., Verwaal, R., de Jong, M. D. M., Muller, W. H., Smits, A., Visser, C., Boonstra, J., Verkleij, A. J., & Verrips, C. T. (2000). Introduction of an N-glycosylation site increases secretion of heterologous proteins in yeasts. Applied and Environmental Microbiology, 66, 4940-4944.