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2024

Scholarly publications

Ma, N., Zhang, M., Zhou, J., Jiang, C., Ghonaim, A. H., Sun, Y., Zhou, P., Guo, G., Evers, A., Zhu, H., He, Q., Lebbink, R. J., Bosch, B. J., & Li, W. (2024). Genome-wide CRISPR/Cas9 library screen identifies C16orf62 as a host dependency factor for porcine deltacoronavirus infection. Emerging microbes & infections, 13(1), Article 2400559. https://doi.org/10.1080/22221751.2024.2400559
https://research-portal.uu.nl/ws/files/240723177/Genome-wide_CRISPR_Cas9_library_screen_identifies_C16orf62_as_a_host_dependency_factor_for_porcine_deltacoronavirus_infection_1_.pdf

Du, W., Debski-Antoniak, O., Drabek, D., van Haperen, R., van Dortmondt, M., van der Lee, J., Drulyte, I., van Kuppeveld, F. J. M., Grosveld, F., Hurdiss, D. L., & Bosch, B.-J. (2024). Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein. Nature Communications, 15(1), Article 5330. https://doi.org/10.1038/s41467-024-49693-0
https://research-portal.uu.nl/ws/files/228901833/s41467-024-49693-0.pdf

Pascha, M. N., Ballegeer, M., Roelofs, M. C., Meuris, L., Albulescu, I. C., van Kuppeveld, F. J. M., Hurdiss, D. L., Bosch, B. J., Zeev-Ben-Mordehai, T., Saelens, X., & de Haan, C. A. M. (2024). Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge. npj Vaccines, 9(1), Article 97. https://doi.org/10.1038/s41541-024-00891-3
https://dspace.library.uu.nl/bitstream/handle/1874/452779/s41541-024-00891-3.pdf?sequence=1

Swart, I. C., Van Gelder, W., De Haan, C. A. M., Bosch, B.-J., & Oliveira, S. (2024). Next generation single-domain antibodies against respiratory zoonotic RNA viruses. Frontiers in Molecular Biosciences, 11, Article 1389548. https://doi.org/10.3389/fmolb.2024.1389548
https://dspace.library.uu.nl/bitstream/handle/1874/452644/fmolb-11-1389548.pdf?sequence=1

Yang, Y.-L., Wang, B., Li, W., Cai, H.-L., Qian, Q.-Y., Qin, Y., Shi, F.-S., Bosch, B.-J., & Huang, Y.-W. (2024). Functional dissection of the spike glycoprotein S1 subunit and identification of cellular cofactors for regulation of swine acute diarrhea syndrome coronavirus entry. Journal of Virology, 98(4), Article e0013924. https://doi.org/10.1128/jvi.00139-24
https://dspace.library.uu.nl/bitstream/handle/1874/438444/yang-et-al-2024-functional-dissection-of-the-spike-glycoprotein-s1-subunit-and-identification-of-cellular-cofactors-for_1_.pdf?sequence=1

Kaiser, F. K., Hernandez, M. G., Krüger, N., Englund, E., Du, W., Mykytyn, A. Z., Raadsen, M. P., Lamers, M. M., Rodrigues Ianiski, F., Shamorkina, T. M., Snijder, J., Armando, F., Beythien, G., Ciurkiewicz, M., Schreiner, T., Gruber-Dujardin, E., Bleyer, M., Batura, O., Erffmeier, L., ... Osterhaus, A. D. M. E. (2024). Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models. Nature Communications, 15(1), Article 2319. https://doi.org/10.1038/s41467-024-46443-0
https://dspace.library.uu.nl/bitstream/handle/1874/436997/s41467-024-46443-0.pdf?sequence=1

Pascha, M. N., Ballegeer, M., Roelofs, M. C., Meuris, L., Albulescu, I. C., Kuppeveld, F. J. M. V., Hurdiss, D. L., Bosch, B.-J., Zeev-Ben-Mordehai, T., Saelens, X., & Haan, C. A. M. D. (2024). Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge in mice. Research Square. https://doi.org/10.21203/rs.3.rs-3579434/v1
https://dspace.library.uu.nl/bitstream/handle/1874/436082/748a8378-0382-43eb-8ee8-d7467ff4d5a6.pdf?sequence=1

2023

Scholarly publications

Gerber, P. F., Cao, D., Xiao, C.-T., Chen, Q., Lager, K., Bosch, B. J., Meng, X.-J., Halbur, P. G., & Opriessnig, T. (2023). Failure to experimentally infect 10 days-old piglets with a cell culture-propagated infectious stock of a classical genotype 1a porcine epidemic diarrhea virus. Frontiers in Veterinary Science, 10, Article 1279162. https://doi.org/10.3389/fvets.2023.1279162
https://dspace.library.uu.nl/bitstream/handle/1874/436999/fvets-10-1279162.pdf?sequence=1

Pronker, M. F., Creutznacher, R., Drulyte, I., Hulswit, R. J. G., Li, Z., van Kuppeveld, F. J. M., Snijder, J., Lang, Y., Bosch, B.-J., Boons, G.-J., Frank, M., de Groot, R. J., & Hurdiss, D. L. (2023). Sialoglycan binding triggers spike opening in a human coronavirus. Nature, 624(7990), 201-206. https://doi.org/10.1038/s41586-023-06599-z
https://dspace.library.uu.nl/bitstream/handle/1874/434377/s41586-023-06599-z.pdf?sequence=1

Thijssen, V., Hurdiss, D. L., Debski-Antoniak, O. J., Spence, M. A., Franck, C., Norman, A., Aggarwal, A., Mokiem, N. J., Dongen, D. A. A. V., Vermeir, S. W., Liu, M., Li, W., Chatziandreou, M., Donselaar, T., Du, W., Drulyte, I., Bosch, B.-J., Snijder, J., Turville, S., ... Jongkees, S. A. K. (2023). A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein. (pp. 1-27). bioRxiv. https://doi.org/10.1101/2022.11.11.516114
https://dspace.library.uu.nl/bitstream/handle/1874/430747/2022.11.11.516114v3.full.pdf?sequence=1

Chatterjee, M., Huang, L. Z. X., Mykytyn, A. Z., Wang, C., Lamers, M. M., Westendorp, B., Wubbolts, R. W., van Putten, J. P. M., Bosch, B.-J., Haagmans, B. L., & Strijbis, K. (2023). Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface. PLoS Pathogens, 19(8), Article e1011571. https://doi.org/10.1371/journal.ppat.1011571
https://dspace.library.uu.nl/bitstream/handle/1874/430874/journal.ppat.1011571.pdf?sequence=1

Duijvestijn, M. B. H. M., Schuurman, N. N. M. P., Vernooij, J. C. M., Leeuwen, M. A. J. M. V., Bosch, B.-J., Brand, J. M. A. V. D., Wagenaar, J. A., Kuppeveld, F. J. M. V., Egberink, H. F., & Verhagen, J. H. (2023). Serological Survey of Retrovirus and Coronavirus Infections, including SARS-CoV-2, in Rural Stray Cats in The Netherlands, 2020–2022. Viruses, 15(7), 1-20. Article 1531. https://doi.org/10.3390/v15071531
https://dspace.library.uu.nl/bitstream/handle/1874/429637/viruses-15-01531.pdf?sequence=1

Gonzalez-Hernandez, M., Kaiser, F. K., Steffen, I., Ciurkiewicz, M., van Amerongen, G., Tchelet, R., Emalfarb, M., Saloheimo, M., Wiebe, M. G., Vitikainen, M., Albulescu, I. C., Bosch, B.-J., Baumgärtner, W., Haagmans, B. L., & Osterhaus, A. D. M. E. (2023). Preclinical immunogenicity and protective efficacy of a SARS-CoV-2 RBD-based vaccine produced with the thermophilic filamentous fungal expression system Thermothelomyces heterothallica C1. Frontiers in Immunology, 14, Article 1204834. https://doi.org/10.3389/fimmu.2023.1204834
https://dspace.library.uu.nl/bitstream/handle/1874/429322/fimmu-14-1204834.pdf?sequence=1

Thijssen, V., Hurdiss, D. L., Debski-Antoniak, O. J., Spence, M. A., Franck, C., Norman, A., Aggarwal, A., Mokiem, N. J., van Dongen, D. A. A., Vermeir, S. W., Liu, M., Li, W., Chatziandreou, M., Donselaar, T., Du, W., Drulyte, I., Bosch, B.-J., Snijder, J., Turville, S. G., ... Jongkees, S. A. K. (2023). A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein. Proceedings of the National Academy of Sciences of the United States of America, 120(26), Article e2303292120. https://doi.org/10.1073/pnas.2303292120
https://dspace.library.uu.nl/bitstream/handle/1874/429162/pnas.2303292120.pdf?sequence=1

Du, W., Janssens, R., Mykytyn, A. Z., Li, W., Drabek, D., van Haperen, R., Chatziandreou, M., Rissmann, M., van der Lee, J., van Dortmondt, M., Martin, I. S., van Kuppeveld, F. J. M., Hurdiss, D. L., Haagmans, B. L., Grosveld, F., & Bosch, B.-J. (2023). Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants. Frontiers in Immunology, 14, Article 1111385. https://doi.org/10.3389/fimmu.2023.1111385
https://dspace.library.uu.nl/bitstream/handle/1874/427398/fimmu_14_1111385.pdf?sequence=1

Rodon, J., Mykytyn, A. Z., Te, N., Okba, N. M. A., Lamers, M. M., Pailler-García, L., Cantero, G., Albulescu, I., Bosch, B.-J., Peiris, M., Bensaid, A., Vergara-Alert, J., Haagmans, B. L., & Segalés, J. (2023). Extended Viral Shedding of MERS-CoV Clade B Virus in Llamas Compared with African Clade C Strain. Emerging Infectious Diseases, 29(3), 585-589. https://doi.org/10.3201/eid2903.220986
https://dspace.library.uu.nl/bitstream/handle/1874/427309/22_0986.pdf?sequence=1

Vermeulen, C. J., Dijkman, R., de Wit, J. J. S., Bosch, B.-J., Heesterbeek, J. A. P. H., & van Schaik, G. (2023). Genetic analysis of infectious bronchitis virus (IBV) in vaccinated poultry populations over a period of 10 years. Avian Pathology, 52(3), 157-167. https://doi.org/10.1080/03079457.2023.2177140
https://dspace.library.uu.nl/bitstream/handle/1874/429422/Genetic_analysis_of_infectious_bronchitis_virus_IBV_in_vaccinated_poultry_populations_over_a_period_of_10_years.pdf?sequence=1

Sikkema, R. S., Bruin, E. D., Ramakers, C., Bentvelsen, R., Li, W., Bosch, B.-J., Westerhuis, B., Haagmans, B., Koopmans, M. P. G., & Fraaij, P. L. A. (2023). Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands. Viruses, 15(1), Article 212. https://doi.org/10.3390/v15010212
https://dspace.library.uu.nl/bitstream/handle/1874/426325/viruses_15_00212_v2.pdf?sequence=1

2022

Scholarly publications

Rothenberger, S., Hurdiss, D. L., Walser, M., Malvezzi, F., Mayor, J., Ryter, S., Moreno, H., Liechti, N., Bosshart, A., Iss, C., Calabro, V., Cornelius, A., Hospodarsch, T., Neculcea, A., Looser, T., Schlegel, A., Fontaine, S., Villemagne, D., Paladino, M., ... Trimpert, J. (2022). The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants. Nature Biotechnology, 40(12), 1845-1854. https://doi.org/10.1038/s41587-022-01382-3
https://dspace.library.uu.nl/bitstream/handle/1874/425626/s41587_022_01382_3.pdf?sequence=1

Rodon, J., Mykytyn, A. Z., Cantero, G., Albulescu, I. C., Bosch, B.-J., Brix, A., Audonnet, J.-C., Bensaid, A., Vergara-Alert, J., Haagmans, B. L., & Segalés, J. (2022). Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas. One Health Outlook, 4(1), 1-5. Article 12. https://doi.org/10.1186/s42522-022-00068-9
https://dspace.library.uu.nl/bitstream/handle/1874/421358/s42522_022_00068_9.pdf?sequence=1

Wang, C., Hesketh, E. L., Shamorkina, T. M., Li, W., Franken, P. J., Drabek, D., van Haperen, R., Townend, S., van Kuppeveld, F. J. M., Grosveld, F., Ranson, N. A., Snijder, J., de Groot, R. J., Hurdiss, D. L., & Bosch, B.-J. (2022). Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes. Nature Communications, 13(1), 1-15. Article 2921. https://doi.org/10.1038/s41467-022-30658-0
https://dspace.library.uu.nl/bitstream/handle/1874/420854/s41467_022_30658_0.pdf?sequence=1

Du, W., Hurdiss, D. L., Drabek, D., Mykytyn, A. Z., Kaiser, F. K., González-Hernández, M., Muñoz-Santos, D., Lamers, M. M., van Haperen, R., Li, W., Drulyte, I., Wang, C., Sola, I., Armando, F., Beythien, G., Ciurkiewicz, M., Baumgärtner, W., Guilfoyle, K., Smits, T., ... Bosch, B.-J. (2022). An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern. Science immunology, 7(73), 1-15. Article eabp9312. https://doi.org/10.1126/sciimmunol.abp9312
https://dspace.library.uu.nl/bitstream/handle/1874/422082/sciimmunol.abp9312.pdf?sequence=1

Rodriguez-Conde, S., Inman, S., Lindo, V., Amery, L., Tang, A., Okorji-Obike, U., Du, W., Bosch, B.-J., Wichgers Schreur, P. J., Kortekaas, J., Sola, I., Enjuanes, L., Kerry, L., Mahal, K., Hulley, M., & Daramola, O. (2022). Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales. mAbs, 14(1), 1-12. Article 2052228. https://doi.org/10.1080/19420862.2022.2052228
https://dspace.library.uu.nl/bitstream/handle/1874/419893/19420862.2022.pdf?sequence=1

2021

Scholarly publications

Chatterjee, M., Huang, L. Z. X., Wang, C., Mykytyn, A. Z., Westendorp, B., Wubbolts, R. W., Bosch, B.-J., Haagmans, B. L., Putten, J. P. M. V., & Strijbis, K. (2021). The glycosylated extracellular domain of MUC1 protects against SARS-CoV-2 infection at the respiratory surface. bioRxiv. https://doi.org/10.1101/2021.10.29.466408
https://dspace.library.uu.nl/bitstream/handle/1874/415173/2021.10.29.466408v1.full.pdf?sequence=1

Beer, M., Amery, L., Bosch, B.-J., Brix, A., Daramola, O., Inman, S., Jungbäck, C., Kortekaas, J., Lindo, V., Okorji-Obike, U., Rodriguez-Conde, S., Tang, A., Tchelet, R., Vandeputte, J., Wichgers Schreur, P. J., Osterhaus, A., Haagmans, B., & Audonnet, J.-C. (2021). Zoonoses Anticipation and Preparedness Initiative, stakeholders conference, February 4 & 5, 2021. Biologicals, 74, 10-15. https://doi.org/10.1016/j.biologicals.2021.10.003
https://dspace.library.uu.nl/bitstream/handle/1874/418973/1_s2.0_S1045105621000853_main.pdf?sequence=1

Langereis, M. A., Albulescu, I. C., Stammen-Vogelzangs, J., Lambregts, M., Stachura, K., Miller, S., Bosco-Lauth, A. M., Hartwig, A. E., Porter, S. M., Allen, M., Mogler, M., van Kuppeveld, F. J. M., Bosch, B.-J., Vermeij, P., de Groof, A., Bowen, R. A., Davis, R., Xu, Z., & Tarpey, I. (2021). An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats. npj Vaccines, 6(1), Article 122. https://doi.org/10.1038/s41541-021-00390-9
https://dspace.library.uu.nl/bitstream/handle/1874/413278/s41541_021_00390_9.pdf?sequence=1

Fenwick, C., Turelli, P., Perez, L., Pellaton, C., Esteves-Leuenberger, L., Farina, A., Campos, J., Lana, E., Fiscalini, F., Raclot, C., Pojer, F., Lau, K., Demurtas, D., Descatoire, M., Joo, V. S., Foglierini, M., Noto, A., Abdelnabi, R., Foo, C. S., ... Pantaleo, G. (2021). A highly potent antibody effective against SARS-CoV-2 variants of concern. Cell Reports, 37(2), Article 109814. https://doi.org/10.1016/j.celrep.2021.109814
https://dspace.library.uu.nl/bitstream/handle/1874/413270/PIIS221112472101278X.pdf?sequence=1

Fröberg, J., Gillard, J., Philipsen, R., Lanke, K., Rust, J., van Tuijl, D., Teelen, K., Bousema, T., Simonetti, E., van der Gaast-de Jongh, C. E., Bos, M., van Kuppeveld, F. J., Bosch, B.-J., Nabuurs-Franssen, M., van der Geest-Blankert, N., van Daal, C., Huynen, M. A., de Jonge, M. I., & Diavatopoulos, D. A. (2021). SARS-CoV-2 mucosal antibody development and persistence and their relation to viral load and COVID-19 symptoms. Nature Communications, 12(1), 1-11. Article 5621. https://doi.org/10.1038/s41467-021-25949-x
https://dspace.library.uu.nl/bitstream/handle/1874/413067/s41467_021_25949_x.pdf?sequence=1

Ni, Y., Rosier, B. J. H. M., van Aalen, E. A., Hanckmann, E. T. L., Biewenga, L., Pistikou, A.-M. M., Timmermans, B., Vu, C., Roos, S., Arts, R., Li, W., de Greef, T. F. A., van Borren, M. M. G. J., van Kuppeveld, F. J. M., Bosch, B.-J., & Merkx, M. (2021). A plug-and-play platform of ratiometric bioluminescent sensors for homogeneous immunoassays. Nature Communications, 12(1), 1-12. Article 4586. https://doi.org/10.1038/s41467-021-24874-3
https://dspace.library.uu.nl/bitstream/handle/1874/412737/s41467_021_24874_3.pdf?sequence=1

van Keulen, B. J., Romijn, M., Bondt, A., Dingess, K. A., Kontopodi, E., van der Straten, K., den Boer, M. A., Burger, J. A., Poniman, M., Bosch, B. J., Brouwer, P. J. M., de Groot, C. J. M., Hoek, M., Li, W., Pajkrt, D., Sanders, R. W., Schoonderwoerd, A., Tamara, S., Timmermans, R. A. H., ... van Goudoever, J. B. (2021). Human Milk from Previously COVID-19-Infected Mothers: The Effect of Pasteurization on Specific Antibodies and Neutralization Capacity. Nutrients, 13(5), 1-14. Article 1645. https://doi.org/10.3390/nu13051645
https://dspace.library.uu.nl/bitstream/handle/1874/412253/nutrients_13_01645.pdf?sequence=1

Sauer, M. M., Tortorici, M. A., Park, Y.-J., Walls, A. C., Homad, L., Acton, O. J., Bowen, J. E., Wang, C., Xiong, X., de van der Schueren, W., Quispe, J., Hoffstrom, B. G., Bosch, B.-J., McGuire, A. T., & Veesler, D. (2021). Structural basis for broad coronavirus neutralization. Nature Structural and Molecular Biology, 28(6), 478-486. https://doi.org/10.1038/s41594-021-00596-4
https://dspace.library.uu.nl/bitstream/handle/1874/418816/s41594_021_00596_4.pdf?sequence=1

Steenhuis, M., van Mierlo, G., Derksen, N. I., Ooijevaar-de Heer, P., Kruithof, S., Loeff, F. L., Berkhout, L. C., Linty, F., Reusken, C., Reimerink, J., Hogema, B., Zaaijer, H., van de Watering, L., Swaneveld, F., van Gils, M. J., Bosch, B. J., van Ham, S. M., Ten Brinke, A., Vidarsson, G., ... Rispens, T. (2021). Dynamics of antibodies to SARS-CoV-2 in convalescent plasma donors. Clinical & translational immunology, 10(5), 1-12. Article e1285. https://doi.org/10.1002/cti2.1285
https://dspace.library.uu.nl/bitstream/handle/1874/412238/cti2.1285.pdf?sequence=1

Haagmans, B. L., Noack, D., Okba, N. M. A., Li, W., Wang, C., Bestebroer, T., de Vries, R., Herfst, S., de Meulder, D., Verveer, E., van Run, P., Lamers, M. M., Rijnders, B., Rokx, C., van Kuppeveld, F., Grosveld, F., Drabek, D., GeurtsvanKessel, C., Koopmans, M., ... Rockx, B. (2021). SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model. Journal of Infectious Diseases, 223(12), 2020-2028. https://doi.org/10.1093/infdis/jiab289
https://dspace.library.uu.nl/bitstream/handle/1874/418815/jiab289.pdf?sequence=1

Fedry, J., Hurdiss, D. L., Wang, C., Li, W., Obal, G., Drulyte, I., Du, W., Howes, S. C., van Kuppeveld, F. J. M., Förster, F., & Bosch, B.-J. (2021). Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11. Science advances, 7(23), 1-11. Article eabf5632. https://doi.org/10.1126/sciadv.abf5632
https://dspace.library.uu.nl/bitstream/handle/1874/418796/sciadv.abf5632.pdf?sequence=1

Zhao, S., Schuurman, N., Li, W., Wang, C., Smit, L. A. M., Broens, E. M., Wagenaar, J. A., van Kuppeveld, F. J. M., Bosch, B.-J., & Egberink, H. (2021). Serologic Screening of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Cats and Dogs during First Coronavirus Disease Wave, the Netherlands. Emerging Infectious Diseases, 27(5), 1362-1370. https://doi.org/10.3201/eid2705.204055
https://dspace.library.uu.nl/bitstream/handle/1874/412008/20_4055.pdf?sequence=1

Wang, C., van Haperen, R., Gutiérrez-Álvarez, J., Li, W., Okba, N. M. A., Albulescu, I., Widjaja, I., van Dieren, B., Fernandez-Delgado, R., Sola, I., Hurdiss, D. L., Daramola, O., Grosveld, F., van Kuppeveld, F. J. M., Haagmans, B. L., Enjuanes, L., Drabek, D., & Bosch, B.-J. (2021). A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies. Nature Communications, 12(1), 1-15. Article 1715. https://doi.org/10.1038/s41467-021-21968-w
https://dspace.library.uu.nl/bitstream/handle/1874/411705/s41467_021_21968_w.pdf?sequence=1

Fenwick, C., Croxatto, A., Coste, A. T., Pojer, F., André, C., Pellaton, C., Farina, A., Campos, J., Hacker, D., Lau, K., Bosch, B.-J., Gonseth Nussle, S., Bochud, M., D'Acremont, V., Trono, D., Greub, G., & Pantaleo, G. (2021). Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies. Journal of Virology, 95(3), Article e01828-20. https://doi.org/10.1128/JVI.01828-20
https://dspace.library.uu.nl/bitstream/handle/1874/432495/fenwick-et-al-2021-changes-in-sars-cov-2-spike-versus-nucleoprotein-antibody-responses-impact-the-estimates-of.pdf?sequence=1

2020

Scholarly publications

Lang, Y., Li, W., Li, Z., Koerhuis, D., van den Burg, A. C. S., Rozemuller, E., Bosch, B.-J., van Kuppeveld, F. J. M., Boons, G.-JPH., Huizinga, E. G., van der Schaar, H. M., & de Groot, R. J. (2020, Apr 5). Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity. https://doi.org/10.1101/2020.04.03.003699

Okba, N. M. A., Widjaja, I., van Dieren, B., Aebischer, A., van Amerongen, G., de Waal, L., Stittelaar, K. J., Schipper, D., Martina, B., van den Brand, J. M. A., Beer, M., Bosch, B.-J., & Haagmans, B. L. (2020). Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV. Emerging Microbes and Infections, 9(1), 1080-1091. https://doi.org/10.1080/22221751.2020.1760735
https://dspace.library.uu.nl/bitstream/handle/1874/410433/Particulate_multivalent_presentation_of_the_receptor_binding_domain_induces_protective_immune_responses_against_MERS_CoV.pdf?sequence=1

van Tol, S., Mögling, R., Li, W., Godeke, G.-J., Swart, A., Bergmans, B., Brandenburg, A., Kremer, K., Murk, J.-L., van Beek, J., Wintermans, B., Reimerink, J., Bosch, B.-J., & Reusken, C. (2020). Accurate serology for SARS-CoV-2 and common human coronaviruses using a multiplex approach. Emerging Microbes and Infections, 9(1), 1965-1973. https://doi.org/10.1080/22221751.2020.1813636
https://dspace.library.uu.nl/bitstream/handle/1874/410432/Accurate_serology_for_SARS_CoV_2_and_common_human_coronaviruses_using_a_multiplex_approach.pdf?sequence=1

Amsterdam University Medical Center COVID-19 Biobank Study Group, (2020). Development of a SARS-CoV-2 Total Antibody Assay and the Dynamics of Antibody Response over Time in Hospitalized and Nonhospitalized Patients with COVID-19. Journal of Immunology, 205(12), 3491-3499. https://doi.org/10.4049/jimmunol.2000767
https://dspace.library.uu.nl/bitstream/handle/1874/410431/3491.full.pdf?sequence=1

Saletti, G., Gerlach, T., Jansen, J. M., Molle, A., Elbahesh, H., Ludlow, M., Li, W., Bosch, B.-J., Osterhaus, A. D. M. E., & Rimmelzwaan, G. F. (2020). Older adults lack SARS CoV-2 cross-reactive T lymphocytes directed to human coronaviruses OC43 and NL63. Scientific Reports, 10(1), 1-10. Article 21447. https://doi.org/10.1038/s41598-020-78506-9
https://dspace.library.uu.nl/bitstream/handle/1874/410430/s41598_020_78506_9.pdf?sequence=1

Lang, Y., Li, W., Li, Z., Koerhuis, D., van den Burg, A. C. S., Rozemuller, E., Bosch, B.-J., van Kuppeveld, F. J. M., Boons, G.-J., Huizinga, E. G., van der Schaar, H. M., & de Groot, R. J. (2020). Coronavirus hemagglutinin-esterase and spike proteins coevolve for functional balance and optimal virion avidity. Proceedings of the National Academy of Sciences of the United States of America, 117(41), 25759-25770. https://doi.org/10.1073/pnas.2006299117
https://dspace.library.uu.nl/bitstream/handle/1874/409176/25759.full.pdf?sequence=1

Wang, C., Li, W., Drabek, D., Okba, N. M. A., van Haperen, R., Osterhaus, A. D. M. E., van Kuppeveld, F. J. M., Haagmans, B. L., Grosveld, F., & Bosch, B.-J. (2020). A human monoclonal antibody blocking SARS-CoV-2 infection. Nature Communications, 11(1), 1-6. Article 2251. https://doi.org/10.1038/s41467-020-16256-y
https://dspace.library.uu.nl/bitstream/handle/1874/396265/s41467_020_16256_y.pdf?sequence=1

Okba, N. M. A., Müller, M. A., Li, W., Wang, C., GeurtsvanKessel, C. H., Corman, V. M., Lamers, M. M., Sikkema, R. S., de Bruin, E., Chandler, F. D., Yazdanpanah, Y., Le Hingrat, Q., Descamps, D., Houhou-Fidouh, N., Reusken, C. B. E. M., Bosch, B.-J., Drosten, C., Koopmans, M. P. G., & Haagmans, B. L. (2020). Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease 2019 Patients. Emerging Infectious Diseases, 26(7), 1478-1488. https://doi.org/10.3201/eid2607.200841
https://dspace.library.uu.nl/bitstream/handle/1874/432522/20-0841.pdf?sequence=1

Okba, N. M. A., Widjaja, I., Li, W., GeurtsvanKessel, C. H., Farag, E. A. B. A., Al-Hajri, M., Park, W. B., Oh, M.-D., Reusken, C. B. M. E., Koopmans, M. P. G., Bosch, B.-J., & Haagmans, B. L. (2020). Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies. Emerging Infectious Diseases, 26(5), 1024-1027. https://doi.org/10.3201/eid2605.190921
https://dspace.library.uu.nl/bitstream/handle/1874/396128/19_0921.pdf?sequence=1

2019

Scholarly publications

Haverkamp, A.-K., Bosch, B. J., Spitzbarth, I., Lehmbecker, A., Te, N., Bensaid, A., Segalés, J., & Baumgärtner, W. (2019). Detection of MERS-CoV antigen on formalin-fixed paraffin-embedded nasal tissue of alpacas by immunohistochemistry using human monoclonal antibodies directed against different epitopes of the spike protein. Veterinary Immunology and Immunopathology, 218, Article 109939. https://doi.org/10.1016/j.vetimm.2019.109939
https://dspace.library.uu.nl/bitstream/handle/1874/396134/1_s2.0_S0165242719301710_main.pdf?sequence=1

Park, Y.-J., Walls, A. C., Wang, Z., Sauer, M. M., Li, W., Tortorici, M. A., Bosch, B.-J., DiMaio, F., & Veesler, D. (2019). Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors. Nature Structural and Molecular Biology, 26(12), 1151-1157. https://doi.org/10.1038/s41594-019-0334-7
https://dspace.library.uu.nl/bitstream/handle/1874/396133/s41594_019_0334_7.pdf?sequence=1

Walls, A. C., Tortorici, M. A., Xiong, X., Snijder, J., Frenz, B., Bosch, B.-J., DiMaio, F., Corti, D., Rey, F. A., & Veesler, D. (2019). Structural Studies of Coronavirus Fusion Proteins. Microscopy and Microanalysis, 25(S2), 1300-1301. https://doi.org/10.1017/s1431927619007232
https://dspace.library.uu.nl/bitstream/handle/1874/396131/structural_studies_of_coronavirus_fusion_proteins.pdf?sequence=1

Widjaja, I., Wang, C., van Haperen, R., Gutiérrez-Álvarez, J., van Dieren, B., Okba, N. M. A., Raj, V. S., Li, W., Fernandez-Delgado, R., Grosveld, F., van Kuppeveld, F. J. M., Haagmans, B. L., Enjuanes, L., Drabek, D., & Bosch, B. J. (2019). Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein. Emerging Microbes and Infections, 8(1), 516-530. https://doi.org/10.1080/22221751.2019.1597644
https://dspace.library.uu.nl/bitstream/handle/1874/396130/Towards_a_solution_to_MERS_protective_human_monoclonal_antibodies_targeting_different_domains_and_functions_of_the_MERS_coronavirus_spike_glycoprotein.pdf?sequence=1

Rodon, J., Okba, N. M. A., Te, N., van Dieren, B., Bosch, B. J., Bensaid, A., Segalés, J., Haagmans, B. L., & Vergara-Alert, J. (2019). Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein. Emerging Microbes and Infections, 8(1), 1593-1603. https://doi.org/10.1080/22221751.2019.1685912
https://dspace.library.uu.nl/bitstream/handle/1874/396129/Blocking_transmission_of_Middle_East_respiratory_syndrome_coronavirus_MERS_CoV_in_llamas_by_vaccination_with_a_recombinant_spike_protein.pdf?sequence=1

Zhao, S., Smits, C., Schuurman, N., Barnum, S., Pusterla, N., Kuppeveld, F. V., Bosch, B.-J., Maanen, K. V., & Egberink, H. (2019). Development and Validation of a S1 Protein-Based ELISA for the Specific Detection of Antibodies against Equine Coronavirus. Viruses, 11(12). https://doi.org/10.3390/v11121109
https://dspace.library.uu.nl/bitstream/handle/1874/389827/Development_and_Validation.pdf?sequence=1

Zhao, S., Li, W., Schuurman, N., van Kuppeveld, F., Bosch, B.-J., & Egberink, H. (2019). Serological Screening for Coronavirus Infections in Cats. Viruses, 11(8), Article 743. https://doi.org/10.3390/v11080743
https://dspace.library.uu.nl/bitstream/handle/1874/384998/viruses_11_00743.pdf?sequence=1

Widagdo, W., Okba, N. M. A., Li, W., de Jong, A., de Swart, R. L., Begeman, L., van den Brand, J. M. A., Bosch, B.-J., & Haagmans, B. L. (2019). Species-Specific Colocalization of Middle East Respiratory Syndrome Coronavirus Attachment and Entry Receptors. Journal of Virology, 93(16). https://doi.org/10.1128/JVI.00107-19
https://dspace.library.uu.nl/bitstream/handle/1874/382692/Species_Specific_Colocalization_of_Middle_East_Respiratory_Syndrome_Coronavirus_Attachment_and_Entry_Receptors.pdf?sequence=1

Alejandra Tortorici, M., Walls, A. C., Lang, Y., Wang, C., Li, Z., Koerhuis, D., Boons, G.-J., Bosch, B.-J., Rey, F. A., de Groot, R. J., & Veesler, D. (2019). Structural basis for human coronavirus attachment to sialic acid receptors. Nature Structural and Molecular Biology, 26(6), 481-489. https://doi.org/10.1038/s41594-019-0233-y
https://dspace.library.uu.nl/bitstream/handle/1874/381062/s41594_019_0233_y.pdf?sequence=1

Hulswit, R. J. G., Lang, Y., Bakkers, M. J. G., Li, W., Li, Z., Schouten, A., Ophorst, B., van Kuppeveld, F. J. M., Boons, G.-J., Bosch, B.-J., Huizinga, E. G., & de Groot, R. J. (2019). Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A. Proceedings of the National Academy of Sciences of the United States of America, 116(7), 2681-2690. https://doi.org/10.1073/pnas.1809667116
https://dspace.library.uu.nl/bitstream/handle/1874/378166/Human.pdf?sequence=1

2018

Scholarly publications

Stalin Raj, V., Okba, N. M. A., Gutierrez-Alvarez, J., Drabek, D., van Dieren, B., Widagdo, W., Lamers, M. M., Widjaja, I., Fernandez-Delgado, R., Sola, I., Bensaid, A., Koopmans, M. P., Segalés, J., Osterhaus, A. D. M. E., Bosch, B. J., Enjuanes, L., & Haagmans, B. L. (2018). Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection. Science advances, 4(8), Article eaas9667. https://doi.org/10.1126/sciadv.aas9667
https://dspace.library.uu.nl/bitstream/handle/1874/375311/raj.pdf?sequence=1

Dortmans, J. C. F. M., Li, W., van der Wolf, P. J., Buter, G. J., Franssen, P. J. M., van Schaik, G., Houben, M., & Bosch, B. J. (2018). Porcine epidemic diarrhea virus (PEDV) introduction into a naive Dutch pig population in 2014. Veterinary Microbiology, 221, 13-18. https://doi.org/10.1016/j.vetmic.2018.05.014
https://dspace.library.uu.nl/bitstream/handle/1874/367573/Porcine.pdf?sequence=1

Li, W., Hulswit, R. J. G., Kenney, S. P., Widjaja, I., Jung, K., Alhamo, M. A., van Dieren, B., van Kuppeveld, F. J. M., Saif, L. J., & Bosch, B.-J. (2018). Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility. Proceedings of the National Academy of Sciences of the United States of America, 115(22), e5135-e5143. https://doi.org/10.1073/pnas.1802879115
https://dspace.library.uu.nl/bitstream/handle/1874/374985/li.pdf?sequence=1

Xiong, X., Tortorici, M. A., Snijder, J., Yoshioka, C., Walls, A. C., Li, W., McGuire, A. T., Rey, F. A., Bosch, B.-J., & Veesler, D. (2018). Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections. Journal of Virology, 92(4), Article e06128-17. https://doi.org/10.1128/JVI.01628-17
https://dspace.library.uu.nl/bitstream/handle/1874/360895/glycan.pdf?sequence=1

2017

Scholarly publications

Walls, A. C., Tortorici, M. A., Snijder, J., Xiong, X., Bosch, B.-J., Rey, F. A., & Veesler, D. (2017). Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion. Proceedings of the National Academy of Sciences of the United States of America, 114(42), 11157-11162. https://doi.org/10.1073/pnas.1708727114
https://dspace.library.uu.nl/bitstream/handle/1874/359949/tectonic.pdf?sequence=1

Guardado-Calvo, P., Atkovska, K., Jeffers, S. A., Grau, N., Backovic, M., Pérez-Vargas, J., de Boer, S. M., Tortorici, M. A., Pehau-Arnaudet, G., Lepault, J., England, P., Rottier, P. J., Bosch, B. J., Hub, J. S., & Rey, F. A. (2017). A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion. Science, 358(6363), 663-667. https://doi.org/10.1126/science.aal2712
https://dspace.library.uu.nl/bitstream/handle/1874/360955/663.full.pdf?sequence=1

Li, W., Hulswit, R. J. G., Widjaja, I., Raj, V. S., McBride, R., Peng, W., Widagdo, W., Tortorici, M. A., van Dieren, B., Lang, Y., van Lent, J. W. M., Paulson, J. C., de Haan, C. A. M., de Groot, R. J., van Kuppeveld, F. J. M., Haagmans, B. L., & Bosch, B.-J. (2017). Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein. Proceedings of the National Academy of Sciences of the United States of America, 114(40), E8508-E8517. https://doi.org/10.1073/pnas.1712592114
https://dspace.library.uu.nl/bitstream/handle/1874/360894/Identification.pdf?sequence=1

Li, C., Li, W., Lucio de Esesarte, E., Guo, H., van den Elzen, P., Aarts, E., van den Born, E., Rottier, P. J. M., & Bosch, B.-J. (2017). Cell Attachment Domains of the Porcine Epidemic Diarrhea Virus Spike Protein Are Key Targets of Neutralizing Antibodies. Journal of Virology, 91(12). https://doi.org/10.1128/JVI.00273-17
https://dspace.library.uu.nl/bitstream/handle/1874/360843/J._Virol._2017_Li_.pdf?sequence=1

Li, W., Luo, R., He, Q., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B.-J. (2017). Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry. Virus Research, 235, 6-13. https://doi.org/10.1016/j.virusres.2017.03.018
https://dspace.library.uu.nl/bitstream/handle/1874/360817/1_s2.0_S0168170217301375_main.pdf?sequence=1

Walls, A., Tortorici, M. A., Bosch, B.-J., Frenz, B., Rottier, P. J. M., DiMaio, F., Rey, F. A., & Veesler, D. (2017). Crucial steps in the structure determination of a coronavirus spike glycoprotein using cryo-electron microscopy. Protein Science, 26(1), 113-121. https://doi.org/10.1002/pro.3048
https://dspace.library.uu.nl/bitstream/handle/1874/345517/Walls_et_al_2017_Protein_Science.pdf?sequence=1

2016

Scholarly publications

Reusken, C. B. E. M., Schilp, C., Raj, V. S., De Bruin, E., Kohl, R. H. G., Farag, E. A. B. A., Haagmans, B. L., Al-Romaihi, H., Le Grange, F., Bosch, B.-J., & Koopmans, M. P. G. (2016). MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic. Emerging Infectious Diseases, 22(6), 1129-1131. https://doi.org/10.3201/eid2206.152113
https://dspace.library.uu.nl/bitstream/handle/1874/346791/15.pdf?sequence=1

Walls, A. C., Tortorici, M. A., Frenz, B., Snijder, J., Li, W., Rey, F. A., DiMaio, F., Bosch, B.-J., & Veesler, D. (2016). Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy. Nature Structural and Molecular Biology, 23(10), 899-905. https://doi.org/10.1038/nsmb.3293
https://dspace.library.uu.nl/bitstream/handle/1874/345997/Glycan.pdf?sequence=1

Hulswit, R. J. G., de Haan, C. A. M., & Bosch, B.-J. (2016). Coronavirus Spike Protein and Tropism Changes. Advances in Virus Research, 96, 29-57. https://doi.org/10.1016/bs.aivir.2016.08.004
https://dspace.library.uu.nl/bitstream/handle/1874/345996/7.pdf?sequence=1

Li, W., van Kuppeveld, F. J. M., He, Q., Rottier, P. J. M., & Bosch, B.-J. (2016). Cellular entry of the porcine epidemic diarrhea virus. Virus Research, 226, 117-127. https://doi.org/10.1016/j.virusres.2016.05.031
https://dspace.library.uu.nl/bitstream/handle/1874/346735/cellular.pdf?sequence=1

Walls, A. C., Tortorici, M. A., Bosch, B.-J., Frenz, B., Rottier, P. J. M., DiMaio, F., Rey, F. A., & Veesler, D. (2016). Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Nature, 531(7592), 114-117. https://doi.org/10.1038/nature16988
https://dspace.library.uu.nl/bitstream/handle/1874/346705/1.pdf?sequence=1

Widagdo, W., Raj, V. S., Schipper, D., Kolijn, K., van Leenders, G. J. L. H., Bosch, B. J., Bensaid, A., Segalés, J., Baumgärtner, W., Osterhaus, A. D. M. E., Koopmans, M. P., van den Brand, J. M. A., & Haagmans, B. L. (2016). Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels. Journal of Virology, 90(9), 4838-4842. https://doi.org/10.1128/JVI.02994-15
https://dspace.library.uu.nl/bitstream/handle/1874/345913/8.pdf?sequence=1

2015

Scholarly publications

Raj, V. S., Lamers, M. M., Smits, S. L., Demmers, J. A. A., Mou, H., Bosch, B.-J., & Haagmans, B. L. (2015). Identification of protein receptors for coronaviruses by mass spectrometry. In H. J. Maier, E. Bickerton, & P. Britton (Eds.), Coronaviruses: Methods and Protocols (pp. 165-182). (Methods in Molecular Biology; Vol. 1282). Springer. https://doi.org/10.1007/978-1-4939-2438-7_15
https://dspace.library.uu.nl/bitstream/handle/1874/394992/Raj2015_Protocol_IdentificationOfProteinRecepto.pdf?sequence=1

Wang, Q., Bosch, B.-J., Vlak, J. M., van Oers, M. M., Rottier, P. J., & van Lent, J. W. M. (2015). Budded baculovirus particle structure revisited. Journal of Invertebrate Pathology, 134, 15-22. https://doi.org/10.1016/j.jip.2015.12.001
https://dspace.library.uu.nl/bitstream/handle/1874/341046/Budded.pdf?sequence=1

Kortekaas, J., Vloet, R. P. M., McAuley, A. J., Shen, X., Bosch, B. J., de Vries, L., Moormann, R. J. M., & Bente, D. A. (2015). Crimean-Congo Hemorrhagic Fever Virus Subunit Vaccines Induce High Levels of Neutralizing Antibodies But No Protection in STAT1 Knockout Mice. Vector-Borne and Zoonotic Diseases, 15(12), 759-64. https://doi.org/10.1089/vbz.2015.1855
https://dspace.library.uu.nl/bitstream/handle/1874/341044/Hemorrhagic.pdf?sequence=1

Reusken, C. B. E. M., Farag, E. A. B. A., Haagmans, B. L., Mohran, K. A., Godeke, G.-J., Raj, S., Alhajri, F., Al-Marri, S. A., Al-Romaihi, H. E., Al-Thani, M., Bosch, B.-J., van der Eijk, A. A., El-Sayed, A. M., Ibrahim, A. K., Al-Molawi, N., Müller, M. A., Pasha, S. K., Drosten, C., AlHajri, M. M., & Koopmans, M. P. G. (2015). Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection, Qatar, 2013-2014. Emerging Infectious Diseases, 21(8), 1422-1425. https://doi.org/10.3201/eid2108.150481
https://dspace.library.uu.nl/bitstream/handle/1874/330598/15_0481.pdf?sequence=1

Müller, M. A., Meyer, B., Corman, V. M., Al-Masri, M., Turkestani, A., Ritz, D., Sieberg, A., Aldabbagh, S., Bosch, B.-J., Lattwein, E., Alhakeem, R. F., Assiri, A. M., Albarrak, A. M., Al-Shangiti, A. M., Al-Tawfiq, J. A., Wikramaratna, P., Alrabeeah, A. A., Drosten, C., & Memish, Z. A. (2015). Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study. The Lancet Infectious Diseases, 15(5), 559-564. https://doi.org/10.1016/S1473-3099(15)70090-3
https://dspace.library.uu.nl/bitstream/handle/1874/330585/middle.pdf?sequence=1

Li, W., Wicht, O., van Kuppeveld, F. J. M., He, Q., Rottier, P. J. M., & Bosch, B.-J. (2015). A single point mutation creating a furin cleavage site in the spike protein renders porcine epidemic diarrhea coronavirus trypsin-independent for cell entry and fusion. Journal of Virology, 89(15), 8077-8081. https://doi.org/10.1128/JVI.00356-15
https://dspace.library.uu.nl/bitstream/handle/1874/395015/Journal_of_Virology_2015_Li_8077.full.pdf?sequence=1

Burkard, C., Verheije, M. H., Haagmans, B. L., van Kuppeveld, F. J., Rottier, P. J. M., Bosch, B.-J., & de Haan, C. A. M. (2015). ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells. Journal of Virology, 89(8), 4434-4448. https://doi.org/10.1128/JVI.03274-14
https://dspace.library.uu.nl/bitstream/handle/1874/349089/ATP1A1.pdf?sequence=1

Other output

Bosch, B. J. (2015). Cellular Entry of the Emerging Porcine Epidemic Diarrhea Virus. Poster session presented at 3rd International OneHealth Congress, Amsterdam, Netherlands.

2014

Scholarly publications

Reusken, C. B., Farag, E. A., Jonges, M., Godeke, G. J., El-Sayed, A. M., Pas, S. D., Raj, V. S., Mohran, K. A., Moussa, H. A., Ghobashy, H., Alhajri, F., Ibrahim, A. K., Bosch, B. J., Pasha, S. K., Al-Romaihi, H. E., Al-Thani, M., Al-Marri, S. A., AlHajri, M. M., Haagmans, B. L., & Koopmans, M. P. (2014). Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels, Qatar, April 2014. Eurosurveillance, 19(23). https://doi.org/10.2807/1560-7917.es2014.19.23.20829
https://dspace.library.uu.nl/bitstream/handle/1874/314707/art20829.pdf?sequence=1

Kortekaas, J., Oreshkova, N., van Keulen, L., Kant, J., Bosch, B. J., Bouloy, M., Moulin, V., Goovaerts, D., & Moormann, R. J. M. (2014). Comparative efficacy of two next-generation Rift Valley fever vaccines. Vaccine, 32(39), 4901-4908. https://doi.org/10.1016/j.vaccine.2014.07.037
https://dspace.library.uu.nl/bitstream/handle/1874/314706/rift.pdf?sequence=1

Drosten, C., Meyer, B., Müller, M. A., Corman, V. M., Al-Masri, M., Hossain, R., Madani, H., Sieberg, A., Bosch, B. J., Lattwein, E., Alhakeem, R. F., Assiri, A. M., Hajomar, W., Albarrak, A. M., Al-Tawfiq, J. A., Zumla, A. I., & Memish, Z. A. (2014). Transmission of MERS-coronavirus in household contacts. New England Journal of Medicine, 371(9), 828-35. https://doi.org/10.1056/NEJMoa1405858
https://dspace.library.uu.nl/bitstream/handle/1874/314705/NEJMoa1405858.pdf?sequence=1

Raj, V. S., Smits, S. L., Provacia, L. B., van den Brand, J. M. A., Wiersma, L., Ouwendijk, W. J. D., Bestebroer, T. M., Spronken, M. I., van Amerongen, G., Rottier, P. J. M., Fouchier, R. A. M., Bosch, B. J., Osterhaus, A. D. M. E., & Haagmans, B. L. (2014). Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus. Journal of Virology, 88(3), 1834-8. https://doi.org/10.1128/JVI.02935-13
https://dspace.library.uu.nl/bitstream/handle/1874/310422/adenosine.pdf?sequence=1

Reusken, C. B. E. M., Messadi, L., Feyisa, A., Ularamu, H., Godeke, G. J., Danmarwa, A., Dawo, F., Jemli, M., Melaku, S., Shamaki, D., Woma, Y., Wungak, Y., Gebremedhin, E. Z., Zutt, I., Bosch, B. J., Haagmans, B. L., & Koopmans, M. P. G. (2014). Geographic distribution of MERS coronavirus among dromedary camels, Africa. Emerging Infectious Diseases, 20(8), 1370-1374. https://doi.org/10.3201/eid2008.140590
https://dspace.library.uu.nl/bitstream/handle/1874/310473/14_0590.pdf?sequence=1

Koraka, P., Bosch, B.-J., Cox, M., Chubet, R., Amerongen, G. V., Lövgren-Bengtsson, K., Martina, B. E. E., Roose, J., Rottier, P. J. M., & Osterhaus, A. D. M. E. (2014). A recombinant rabies vaccine expressing the trimeric form of the glycoprotein confers enhanced immunogenicity and protection in outbred mice. Vaccine, 32(36), 4644-4650. https://doi.org/10.1016/j.vaccine.2014.06.058
https://dspace.library.uu.nl/bitstream/handle/1874/310421/mice.pdf?sequence=1

Burkard, C., Bloyet, L. M., Wicht, O., Van Kuppeveld, F. J., Rottier, P. J. M., De Haan, C. A. M., & Bosch, B. J. (2014). Dissecting virus entry: Replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of β-galactosidase. PLoS One, 9(7), Article e101762. https://doi.org/10.1371/journal.pone.0101762
https://dspace.library.uu.nl/bitstream/handle/1874/310483/journal.pone.0101762.pdf?sequence=1

Corman, V. M., Jores, J., Meyer, B., Younan, M., Liljander, A., Said, M. Y., Gluecks, I., Lattwein, E., Bosch, B. J., Drexler, J. F., Bornstein, S., Drosten, C., & Müller, M. A. (2014). Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992-2013. Emerging Infectious Diseases, 20(8), 1319-1322. https://doi.org/10.3201/eid2008.140596
https://dspace.library.uu.nl/bitstream/handle/1874/310424/Kenya.pdf?sequence=1

Memish, Z. A., Cotten, M., Meyer, B., Watson, S. J., Alsahafi, A. J., Al Rabeeah, A. A., Corman, V. M., Sieberg, A., Makhdoom, H. Q., Assiri, A., Al Masri, M., Aldabbagh, S., Bosch, B. J., Beer, M., Müller, M. A., Kellam, P., & Drosten, C. (2014). Human Infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013. Emerging Infectious Diseases, 20(6), 1012-1015. https://doi.org/10.3201/eid2006.140402
https://dspace.library.uu.nl/bitstream/handle/1874/310474/14_0402.pdf?sequence=1

Meyer, B., Müller, M. A., Corman, V. M., Reusken, C. B. E. M., Ritz, D., Godeke, G. J., Lattwein, E., Kallies, S., Siemens, A., van Beek, J., Drexler, J. F., Muth, D., Bosch, B. J., Wernery, U., Koopmans, M. P. G., Wernery, R., & Drosten, C. (2014). Antibodies against MERS coronavirus in dromedaries, United Arab Emirates, 2003 and 2013. Emerging Infectious Diseases, 20(4), 552-559. https://doi.org/10.3201/eid2004.131746
https://dspace.library.uu.nl/bitstream/handle/1874/310423/antibodies.pdf?sequence=1

Bosch, B. J., Smits, S. L., & Haagmans, B. L. (2014). Membrane ectopeptidases targeted by human coronaviruses. Current Opinion in Virology, 6(1), 55-60. https://doi.org/10.1016/j.coviro.2014.03.011
https://dspace.library.uu.nl/bitstream/handle/1874/310435/1_s2.0_S1879625714000716_main.pdf?sequence=1

Müller, M. A., Corman, V. M., Jores, J., Meyer, B., Younan, M., Liljander, A., Bosch, B.-J., Lattwein, E., Hilali, M., Musa, B. E., Bornstein, S., & Drosten, C. (2014). MERS Coronavirus Neutralizing Antibodies in Camels, Eastern Africa, 1983-1997. Emerging Infectious Diseases, 20(12), 2093-2095. https://doi.org/10.3201/eid2012.141026
https://dspace.library.uu.nl/bitstream/handle/1874/310410/mers.pdf?sequence=1

Wicht, O., Burkard, C., de Haan, C. A. M., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2014). Identification and characterization of a proteolytically primed form of the murine coronavirus spike proteins after fusion with the target cell. Journal of Virology, 88(9), 4943-4952. https://doi.org/10.1128/JVI.03451-13
https://dspace.library.uu.nl/bitstream/handle/1874/310434/J._Virol._2014_Wicht_4943_52.pdf?sequence=1

Burkard, C., Verheije, M. H., Wicht, O., van Kasteren, S. I., van Kuppeveld, F. J., Haagmans, B. L., Pelkmans, L., Rottier, P. J. M., Bosch, B. J., & de Haan, C. A. M. (2014). Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner. PLoS Pathogens, 10(11), Article e1004502. https://doi.org/10.1371/journal.ppat.1004502
https://dspace.library.uu.nl/bitstream/handle/1874/310419/proteoly.pdf?sequence=1

Wicht, O., Li, W., Willems, L., Meuleman, T. J., Wubbolts, R. W., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2014). Proteolytic Activation of the Porcine Epidemic Diarrhea Coronavirus Spike Fusion Protein by Trypsin in Cell Culture. Journal of Virology, 88(14), 7952-7961. https://doi.org/10.1128/JVI.00297-14
https://dspace.library.uu.nl/bitstream/handle/1874/310418/J._Virol._2014_Wicht_7952_61.pdf?sequence=1

Other output

Haagmans, B. L., Bestebroer, T. M., van Boheemen, S., Fouchier, R. A. M., Osterhaus, A., Zaki, A., Stalin Raj, V., & Bosch, B. J. (2014). Human betacoronavirus lineage c and identification of n-terminal dipeptidyl peptidase as its virus receptor. http://www.google.com/patents/WO2014045254A3?cl=en

2013

Scholarly publications

Milewska, A., Ciejka, J., Kaminski, K., Karewicz, A., Bielska, D., Zeglen, S., Karolak, W., Nowakowska, M., Potempa, J., Bosch, B. J., Pyrc, K., & Szczubialka, K. (2013). Novel polymeric inhibitors of HCoV-NL63. Antiviral Research, 97(2), 112-121. https://doi.org/10.1016/j.antiviral.2012.11.006
https://dspace.library.uu.nl/bitstream/handle/1874/378697/1_s2.0_S0166354212002616_main.pdf?sequence=1

Raj, V. S., Mou, H., Smits, S. L., Dekkers, D. H. W., Müller, M. A., Dijkman, R., Muth, D., Demmers, J. A. A., Zaki, A., Fouchier, R. A. M., Thiel, V., Drosten, C., Rottier, P. J. M., Osterhaus, A. D. M. E., Bosch, B. J., & Haagmans, B. L. (2013). Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature, 495(7440), 251-4. https://doi.org/10.1038/nature12005
https://dspace.library.uu.nl/bitstream/handle/1874/395061/nature12005.pdf?sequence=1

Reusken, C., Mou, H., Godeke, G. J., van der Hoek, L., Meyer, B., Müller, M. A., Haagmans, B., de Sousa, R., Schuurman, N., Dittmer, U., Rottier, P., Osterhaus, A., Drosten, C., Bosch, B. J., & Koopmans, M. (2013). Specific serology for emerging human coronaviruses by protein microarray. Eurosurveillance, 18(14), Article 20441. https://doi.org/10.2807/1560-7917.ES2013.18.14.20441
https://dspace.library.uu.nl/bitstream/handle/1874/394937/art20441_en.pdf?sequence=1

Reusken, C. B. E. M., Haagmans, B. L., Müller, M. A., Gutierrez, C., Godeke, G.-J., Meyer, B., Muth, D., Raj, V. S., Smits-De Vries, L., Corman, V. M., Drexler, J.-F., Smits, S. L., El Tahir, Y. E., De Sousa, R., van Beek, J., Nowotny, N., van Maanen, K., Hidalgo-Hermoso, E., Bosch, B.-J., ... Koopmans, M. P. G. (2013). Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. The Lancet Infectious Diseases, 13(10), 859-66. https://doi.org/10.1016/S1473-3099(13)70164-6
https://dspace.library.uu.nl/bitstream/handle/1874/394936/PIIS1473309913701646.pdf?sequence=1

Li, C., Li, Z., Zou, Y., Wicht, O., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2013). Manipulation of the porcine epidemic diarrhea virus genome using targeted RNA recombination. PLoS One, 8(8), Article e69997. https://doi.org/10.1371/journal.pone.0069997
https://dspace.library.uu.nl/bitstream/handle/1874/395060/journal.pone.0069997.PDF?sequence=1

Bosch, B. J., Raj, V. S., & Haagmans, B. L. (2013). Spiking the MERS-coronavirus receptor. Cell Research, 23(9), 1069-70. https://doi.org/10.1038/cr.2013.108
https://dspace.library.uu.nl/bitstream/handle/1874/394935/cr2013108.pdf?sequence=1

Ohnuma, K., Haagmans, B. L., Hatano, R., Raj, V. S., Mou, H., Iwata, S., Dang, N. H., Bosch, B. J., & Morimoto, C. (2013). Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody. Journal of Virology, 87(24), 13892-9. https://doi.org/10.1128/JVI.02448-13
https://dspace.library.uu.nl/bitstream/handle/1874/394934/Journal_of_Virology_2013_Ohnuma_13892.full.pdf?sequence=1

Mou, H., Stalin Raj, V., van Kuppeveld, F. J. M., Rottier, P. J. M., Haagmans, B. L., & Bosch, B. J. (2013). The Receptor Binding Domain of the New Middle East Respiratory Syndrome Coronavirus Maps to a 231-Residue Region in the Spike Protein That Efficiently Elicits Neutralizing Antibodies. Journal of Virology, 87(16), 9379-9383. https://doi.org/10.1128/JVI.01277-13
https://dspace.library.uu.nl/bitstream/handle/1874/309929/Mou_H._et_al._J_Virol_2013_Aug_87_16_9379_9383.pdf?sequence=1

Reusken, C., Ababneh, M., Meyer, B., Eljarah, A., Abutarbush, S., Godeke, G. J., Bestebroer, T. M., Zutt, I., Müller, M. A., Bosch, B. J., Rottier, P. J. M., Osterhaus, A. D. M. E., Drosten, C., Haagmans, B. L., & Koopmans, M. P. (2013). Middle East Respiratory Syndrome Coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan. Eurosurveillance, 18(50), Article 20662. https://doi.org/10.2807/1560-7917.ES2013.18.50.20662
https://dspace.library.uu.nl/bitstream/handle/1874/394932/art20662_en.pdf?sequence=1

Popularising publications

Bosch, B. J. (2013). Verraderlijk Mers-virus slaat ook in Europa toe. Dagblad Trouw.

Bosch, B. J. (2013). Sinister virus uit Saoedi- Arabië treft mens en dier. NRC Handelsblad.

Bosch, B. J. (2013). Snel onderzoek naar bron coronavirus. Algemeen Nederlands Persbureau.

Other output

Burkard, C., Verheije, M. H., Wicht, O., Rottier, P. J. M., Bosch, B. J., & de Haan, C. A. M. (2013). Murine hepatitis coronavirus is a late penetrating virus that requires a functional HOPS complex for fusion. Poster session presented at 5th European Congress of Virology.

Bosch, B. J. (2013). Ontdekking van de receptor van het humaan corona virus EMC. Digital or Visual Products, Universiteit Utrecht, You Tube.

2012

Scholarly publications

Nolte - t Hoen, E. N. M., van der Vlist, E. J., Aalberts, M., Mertens, H. C. H., Bosch, B. J., Bartelink, W., Mastrobattista, E., van Gaal, E. V. B., Stoorvogel, W., Arkesteijn, G. J. A. A., & Wauben, M. H. M. (2012). Quantitative and qualitative flow cytometric analysis of nanosized cell-derived membrane vesicles. Nanomedicine : nanotechnology, biology and medicine, 8(5), 712-720. https://doi.org/10.1016/j.nano.2011.09.006
https://dspace.library.uu.nl/bitstream/handle/1874/395606/1_s2.0_S1549963411003637_main.pdf?sequence=1

de Boer, S. M., Kortekaas, J., Spel, L., Rottier, P. J. M., Moormann, R. J. M., & Bosch, B. J. (2012). Acid-activated structural reorganization of the Rift Valley fever virus Gc fusion protein. Journal of Virology, 86(24), 13642-13652. https://doi.org/10.1128/JVI.01973-12
https://dspace.library.uu.nl/bitstream/handle/1874/395602/Journal_of_Virology_2012_de_Boer_13642.full.pdf?sequence=1

Kortekaas, J., Antonis, A. F. G., Kant, J., Vloet, R. P. M., Vogel, A., Oreshkova, N. D., de Boer, S. M., Bosch, B. J., & Moormann, R. J. M. (2012). Efficacy of three candidate Rift Valley fever vaccines in sheep. Vaccine, 30(23), 3423-3429. https://doi.org/10.1016/j.vaccine.2012.03.027
https://dspace.library.uu.nl/bitstream/handle/1874/275132/Kortekaas_%2520J.%2520et%2520al%2520Vaccine%252030%2520%282012%29%25203423-3429.pdf?sequence=1

de Boer, S. M., Kortekaas, J., de Haan, C. A. M., Rottier, P. J. M., Moormann, R. J. M., & Bosch, B. J. (2012). Heparan sulfate facilitates Rift Valley fever virus entry into the cell. Journal of Virology, 86(24), 13767-13771. https://doi.org/10.1128/JVI.01364-12
https://dspace.library.uu.nl/bitstream/handle/1874/274922/Boer_%2520S.M.%2520de%2520et%2520al%2520.%2520J.%2520Virol%25202012_%2520Vol%252086_%2520No%252024.%252013767-13771.pdf?sequence=1

Other output

Leenhouts, K., Haijema, B. J., van Roosmalen, M., Rottier, P., de Haan, X., & Bosch, B. J. (2012). Immunogenic compositions in particulate form and methods for producing the same.

2011

Other output

de Boer, S. M., Spel, L., Rottier, P. J. M., Moormann, R. J. M., & Bosch, B. J. (2011, Oct 31). Entry of Rift Valley fever virus.

Rottier, P. J. M., de Haan, C. A. M., & Bosch, B. J. (2011). Recombinant multimeric influenza proteins. (Patent No. WO 2011/126370).

de Boer, S. M., Spel, L., Rottier, P. J. M., Moormann, R. J. M., & Bosch, B. J. (2011, Sept 15). Entry of Rift Valley fever virus.

2010

Scholarly publications

de Vries, R. P., de Vries, E., Bosch, B. J., de Groot, R. J., Rottier, P. J. M., & de Haan, C. A. M. (2010). The influenza A virus hemagglutinin glycosylation state affects receptor-binding specificity. Virology, 403(1), 17-25. https://doi.org/10.1016/j.virol.2010.03.047
https://dspace.library.uu.nl/bitstream/handle/1874/395604/1_s2.0_S0042682210002308_main.pdf?sequence=1

Bosch, B. J., Bodewes, R., de Vries, R. P., Kreijtz, J. H. C. M., Bartelink, W., van Amerongen, G., Rimmelzwaan, G. F., de Haan, C. A. M., Osterhaus, A. D. M. E., & Rottier, P. J. M. (2010). Recombinant soluble, multimeric HA and NA exhibit distinctive types of protection against pandemic swine-origin 2009 A(H1N1) influenza virus infection in ferrets. Journal of Virology, 84(19), 10366-10374. https://doi.org/10.1128/JVI.01035-10
https://dspace.library.uu.nl/bitstream/handle/1874/395603/Journal_of_Virology_2010_Bosch_10366.full.pdf?sequence=1

de Boer, S. M., Kortekaas, J., Antonis, A. F. G., Kant, J., van Oploo, J. L., Rottier, P. J. M., Moormann, R. J. M., & Bosch, B. J. (2010). Rift Valley fever virus subunit vaccines confer complete protection against a lethal virus challenge. Vaccine, 28(11), 2330-2339. https://doi.org/10.1016/j.vaccine.2009.12.062
https://dspace.library.uu.nl/bitstream/handle/1874/202886/1_s2.0_S0264410X09019793_main.pdf?sequence=3

Other output

Bosch, B. J., de Vries, R. P., Cornelissen, L., Bodewes, R., Kreijtz, J., Bartelink, W., Osterhaus, A. D., de Haan, C. A. M., & Rottier, P. J. M. (2010). A novel, effective and versatile vaccine approach against influenza: multimeric recombinant HA and NA glycoproteins. Poster session presented at 4th Vaccine and ISV Annual Global Congress, Vienna, Austria.

de Vries, R. P., Bosch, B. J., Cornelissen, L., Bodewes, R., Kreijtz, J., Bartelink, W., Osterhaus, A. D. M. E., de Haan, C. A. M., & Rottier, P. J. M. (2010). A novel, effective and versatile vaccine approach against influenza: multimeric recombinant HA and NA glycoproteins. Poster session presented at Options for the Control of Influenza VII, Hong Kong, China.

Nolte-'t Hoen, E. N. M., van der Vlist, E. J., Mertens, H. C. H., Mastrobattista, E., van Gaal, E. V. B., Bosch, B. J., Stoorvogel, W., Arkesteijn, G., & Wauben, M. H. M. (2010). Flow cytometric analysis of individual biological nanoparticles. Abstract from 9th International Conference on New Trends in Immunosuppression and Immunotherapy 2010, Geneva, Switzerland.

Wicht, O., Rottier, P. J. M., & Bosch, B. J. (2010). Coronavirus cell entry: kinetics and cleavage of its spike fusion protein. Poster session presented at Eurovirology 2010 Conference, Como, Italy.

de Haan, C. A. M., Bosch, B. J., & Rottier, P. J. M. (2010). Recombinant multimeric influenza proteins. (Patent No. EP10159552.8).

2009

Scholarly publications

Barcena, M., Oostergetel, G. T., Bartelink, W., Faas, F. G. A., Verkleij, A. J., Rottier, P. J. M., Koster, A. J., & Bosch, B. J. (2009). Cryo-electron tomography of mouse hepatitis virus: Insights into the structure of the coronavirus. Proceedings of the National Academy of Sciences of the United States of America, 106(2), 582-587. https://doi.org/10.1073/pnas.0805270106
https://dspace.library.uu.nl/bitstream/handle/1874/39460/Barcena_%2520M.%2520et%2520al%2520Cryo-electron%2520tomo.pdf?sequence=1

2008

Scholarly publications

Bosch, B. J., Rossen, J. W. A., Bartelink, W., Zuurveen, S. J., de Haan, C. A. M., Duquerroy, S., Boucher, C. A. B., & Rottier, P. J. M. (2008). Coronavirus escape from heptad repeat 2 (HR2)-derived peptide entry inhibition as a result of mutations in the HR1 domain of the spike fusion protein. Journal of Virology, 82(5), 2580-2585. https://doi.org/10.1128/JVI.02287-07
https://dspace.library.uu.nl/bitstream/handle/1874/395088/Journal_of_Virology_2008_Bosch_2580.full.pdf?sequence=1

Bosch, B. J., Bartelink, W., & Rottier, P. J. M. (2008). Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide. Journal of Virology, 82(17), 8887-8890. https://doi.org/10.1128/JVI.00415-08
https://dspace.library.uu.nl/bitstream/handle/1874/32149/Bosch_%2520B.J.%2520et%2520al.%2520Cathepsin%2520L..%2520J.Virol%2520Sept%25202008.pdf?sequence=1

2007

Scholarly publications

van der Meer, F. J. U. M., de Haan, C. A. M., Schuurman, N. M. P., Haijema, B. J., Verheije, M. H., Bosch, B. J., Balzarini, J., & Egberink, H. F. (2007). The carbohydrate-binding plant lectins and the non-peptidic antibiotic pradimicin A target the glycans of the coronavirus envelope glycoproteins. Journal of Antimicrobial Chemotherapy, 60(4), 741-749. https://doi.org/10.1093/jac/dkm301
https://dspace.library.uu.nl/bitstream/handle/1874/395082/Meer_%2520van%2520der%2520F.J.%2520et%2520al_%2520J.%2520Antimicrob%2520%2520Chem%2520%2520%282007%29%252060_%2520741-749.pdf?sequence=1

Bosch, B. J., & Rottier, P. J. M. (2007). Nidovirus entry into cells. In S. Perlman, T. Gallagher, & E. J. Snijder (Eds.), Nidoviruses (pp. 157-178).

2006

Scholarly publications

Huang, I.-C., Bosch, B. J., Li, F., Li, W., Lee, K. H., Ghiran, S., Vasilieva, N., Dermody, T. S., Harrison, S. C., Dormitzer, P. R., Farzan, M., Rottier, P. J. M., & Choe, H. (2006). SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. Journal of Biological Chemistry, 281(6), 3198-203. https://doi.org/10.1074/jbc.M508381200
https://dspace.library.uu.nl/bitstream/handle/1874/394940/J._Biol._Chem._2006_Huang_3198_203.pdf?sequence=1

Pyrc, K., Bosch, B. J., Berkhout, B., Jebbink, M. F., Dijkman, R., Rottier, P., & van der Hoek, L. (2006). Inhibition of human coronavirus NL63 infection at early stages of the replication cycle. Antimicrobial Agents and Chemotherapy, 50(6), 2000-8. https://doi.org/10.1128/AAC.01598-05
https://dspace.library.uu.nl/bitstream/handle/1874/394939/Antimicrobial_Agents_and_Chemotherapy_2006_Pyrc_2000.full.pdf?sequence=1

de Haan, C. A. M., Te Lintelo, E., Li, Z., Raaben, M., Wurdinger, T., Bosch, B. J., & Rottier, P. J. M. (2006). Cooperative involvement of the S1 and S2 subunits of the murine coronavirus spike protein in receptor binding and extended host range. Journal of Virology, 80(22), 10909-10918. https://doi.org/10.1128/JVI.00950-06
https://dspace.library.uu.nl/bitstream/handle/1874/395063/Journal_of_Virology_2006_de_Haan_10909.full.pdf?sequence=1

Würdinger, T., Verheije, M. H., van der Aa, L. M., Bosch, B. J., de Haan, C. A. M., van Beusechem, V. W., Gerritsen, W. R., & Rottier, P. J. M. (2006). Antibody-mediated targeting of viral vectors to the Fc receptor expressed on acute myeloid leukemia cells. Leukemia. Leukemia, 20(12), 2182-2184. https://doi.org/10.1038/sj.leu.2404422
https://dspace.library.uu.nl/bitstream/handle/1874/395636/2404422.pdf?sequence=1

Huang, I. C., Bosch, B. J., Li, W., Farzan, M., Rottier, P. J. M., & Choe, H. (2006). H. SARS-CoV, but not HCoV-NL63, utilizes cathepsins to infect cells: viral entry. Advances in Experimental Medicine and Biology, 581, 335-338. https://doi.org/10.1007/978-0-387-33012-9_60
https://dspace.library.uu.nl/bitstream/handle/1874/394931/Huang2006_Chapter_SARS_CoVButNotHCoV_NL63Utilize.pdf?sequence=1

2005

Scholarly publications

Duquerroy, S., Vigouroux, A., Rottier, P. J. M., Rey, F. A., & Bosch, B. J. (2005). Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein. Virology, 335(2), 276-85. https://doi.org/10.1016/j.virol.2005.02.022
https://dspace.library.uu.nl/bitstream/handle/1874/394941/1_s2.0_S0042682205001200_main.pdf?sequence=1

de Haan, C. A. M., Li, Z., te Lintelo, E., Bosch, B. J., Haijema, B. J., & Rottier, P. J. M. (2005). Murine coronavirus with an extended host range uses heparan sulfate as an entry receptor. Journal of Virology, 79(22), 14451-14456. https://doi.org/10.1128/JVI.79.22.14451-14456.2005
https://dspace.library.uu.nl/bitstream/handle/1874/395064/Journal_of_Virology_2005_de_Haan_14451.full.pdf?sequence=1

Bosch, B. J., de Haan, C. A. M., Smits, S. L., & Rottier, P. J. M. (2005). Spike protein assembly into the coronavirion: exploring the limits of its sequence requirements. Virology, 334(2), 306-318. https://doi.org/10.1016/j.virol.2005.02.001
https://dspace.library.uu.nl/bitstream/handle/1874/11719/Bosch_05_SassemblyVirol.pdf?sequence=2

Würdinger, T., Verheije, M. H., Raaben, M., Bosch, B. J., de Haan, C. A. M., van Beusechem, V. W., Rottier, P. J. M., & Gerritsen, W. R. (2005). Targeting non-human coronaviruses to human cancer cells using a bispecific single-chain antibody. Gene Therapy, 12(18), 1394-1404. https://doi.org/10.1038/sj.gt.3302535
https://dspace.library.uu.nl/bitstream/handle/1874/11732/Wurdinger_05_GeneTher.pdf?sequence=2

Würdinger, T., Verheije, M. H., Broen, K., Bosch, B. J., Haijema, B. J., de Haan, C. A. M., van Beusechem, V. W., Gerritsen, W. R., & Rottier, P. J. M. (2005). Soluble receptor-mediated targeting of mouse hepatitis coronavirus to the human epidermal growth factor receptor. Journal of Virology, 79(24), 15314-15322. https://doi.org/10.1128/JVI.79.24.15314-15322.2005
https://dspace.library.uu.nl/bitstream/handle/1874/11733/Wurdinger_05_soR425JV.pdf?sequence=2

2004

Scholarly publications

de Haan, C. A. M., Stadler, K., Godeke, G.-J., Bosch, B. J., & Rottier, P. J. M. (2004). Cleavage inhibition of the murine coronavirus spike protein by a furin-like enzyme affects cell-cell but not virus-cell fusion. Journal of Virology, 78(11), 6048-54. https://doi.org/10.1128/JVI.78.11.6048-6054.2004
https://dspace.library.uu.nl/bitstream/handle/1874/395066/Journal_of_Virology_2004_de_Haan_6048.full.pdf?sequence=1

Bosch, B. J., Martina, B. E. E., Van Der Zee, R., Lepault, J., Haijema, B. J., Versluis, C., Heck, A. J. R., De Groot, R., Osterhaus, A. D. M. E., & Rottier, P. J. M. (2004). Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. Proceedings of the National Academy of Sciences of the United States of America, 101(22), 8455-8460. https://doi.org/10.1073/pnas.0400576101
https://dspace.library.uu.nl/bitstream/handle/1874/394942/8455.full.pdf?sequence=1

Bosch, B. J., de Haan, C. A. M., & Rottier, P. J. M. (2004). Coronavirus spike glycoprotein, extended at the carboxy terminus with green fluorescent protein, is assembly competent. Journal of Virology, 78(14), 7369-78. https://doi.org/10.1128/JVI.78.14.7369-7378.2004
https://dspace.library.uu.nl/bitstream/handle/1874/395065/Journal_of_Virology_2004_Bosch_7369.full.pdf?sequence=1

Bosch, B. J. (2004). The Coronavirus spike protein: mechanisms of membrane fusion and virion incorporation. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Utrecht University.

Other output

Rottier, P., de Haan, X., Haijema, B. J., & Bosch, B. J. (2004). Coronavirus-like particles comprising functionally deleted genomes.

Verheije, M. H., Würdinger, T., Raaben, M., Bosch, B. J., van Beusechem, V. W., de Haan, C. A. M., Rottier, P. J. M., & Gerritsen, W. R. (2004). Non-human coronaviruses as potential tool for cancer therapy: selective targeting to and effective eradication of human tumor cells in vitro. Poster session presented at 7th international symposium on positive strand RNA viruses, San Francisco (USA).

2003

Scholarly publications

Bosch, B. J., van der Zee, R., de Haan, C. A. M., & Rottier, P. J. M. (2003). The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex. Journal of Virology, 77(16), 8801-11. https://doi.org/10.1128/JVI.77.16.8801-8811.2003
https://dspace.library.uu.nl/bitstream/handle/1874/395067/Journal_of_Virology_2003_Bosch_8801.full.pdf?sequence=1

2001

Scholarly publications

Theilmann, D. A., Willis, L. G., Bosch, B. J., Forsythe, I. J., & Li, Q. (2001). The baculovirus transcriptional transactivator ie0 produces multiple products by internal initiation of translation. Virology, 290(2), 211-23. https://doi.org/10.1006/viro.2001.1165
https://dspace.library.uu.nl/bitstream/handle/1874/395637/1_s2.0_S0042682201911651_main.pdf?sequence=1

See publications on the UU Research Portal

Dr. ir. B.J. (Berend Jan) Bosch

Dr. ir. B.J. (Berend Jan) Bosch

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2024

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2023

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2022

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2021

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2020

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2019

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2018

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2017

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2016

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2015

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2014

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2013

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Popularising publications

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2012

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2011

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2010

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2009

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2008

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2007

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2006

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2005

Scholarly publications

2004

Scholarly publications

Other output

2003

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2001

Scholarly publications

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